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README.md
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pipeline_tag: text-generation
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---
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## Llamacpp imatrix Quantizations of Palmyra-Med-70B-32K
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---
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base_model: Writer/Palmyra-Med-70B-32K
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language:
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- en
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license: other
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license_name: writer-open-model-license
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license_link: https://writer.com/legal/open-model-license/
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pipeline_tag: text-generation
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tags:
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- instruct
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- finetune
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- DPO
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- distillation
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- heathcare
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- medical
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- clinical
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- med
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- lifescience
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- Pharmaceutical
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- Pharma
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- Enterprise LLM
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- Enterprise
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- Enterprise ready
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quantized_by: bartowski
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extra_gated_prompt: By clicking "Agree", you agree to the [License Agreement](https://writer.com/legal/open-model-license/)
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and acknowledge Writer's [Privacy Policy](https://writer.com/legal/acceptable-use/).
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extra_gated_fields:
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Name: text
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Email: text
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Organization or Affiliation: text
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Receive email updates and promotions on Writer products, services, and research?:
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type: select
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options:
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- 'Yes'
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- 'No'
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I acknowledge that this model is for non-commercial use only unless I acquire a separate license from Writer: checkbox
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widget:
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- example_title: Palmyra-Med-70B-32k
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messages:
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- role: system
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content: You are a highly knowledgeable and experienced expert in the healthcare
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and biomedical field, possessing extensive medical knowledge and practical expertise.
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- role: user
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content: Does danzhi Xiaoyao San ameliorate depressive-like behavior by shifting
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toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase?
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output:
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text: Danzhi Xiaoyao San (DXS) exhibited significant antidepressant-like effects
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in rats subjected to chronic unpredictable mild stress (CUMS), a commonly used
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model for inducing depressive-like behavior. The administration of DXS led to
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a notable reduction in the activity of indoleamine 2,3-dioxygenase (IDO) in
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the hippocampus. This reduction in IDO activity is crucial because IDO is an
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enzyme that catalyzes the degradation of tryptophan into kynurenine (Kyn), thereby
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diverting tryptophan away from the serotonin (5-HT) synthesis pathway. By downregulating
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IDO, DXS effectively shifts the balance of tryptophan metabolism towards increased
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serotonin production, thereby enhancing the availability of serotonin. This
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shift in the Kyn/5-HT pathway favoring serotonin is likely a key mechanism underlying
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the antidepressant effects observed with DXS treatment. Enhanced serotonin levels
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in the hippocampus are associated with improved mood and reduction of depressive
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symptoms, suggesting that DXS could be a promising therapeutic agent for managing
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depression.
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model-index:
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- name: Palmyra-Med-70B-32k
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results: []
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---
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## Llamacpp imatrix Quantizations of Palmyra-Med-70B-32K
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