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800 | Степень достоверности полученных результатов. | [
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801 | Достоверность полученных данных основана на достаточном количестве выполненных исследований (1400 ультразвуковых исследований), на использовании достаточного числа современных диагностических методов и поверенного оборудования, на применении критериев доказательной медицины и экспертизе первичной документации, оформлявшейся на всех этапах исследования. | [
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802 | Итоговые данные и результаты исследования соотносятся с целью работы и поставленными задачами. | [
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803 | Личный вклад в диссертационную работу состоит в том, что автором проанализирована научная литература по изучаемой проблеме - как отечественная, так и зарубежная. | [
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804 | Соискатель непосредственно принимала участие в ультразвуковых исследованиях органов малого таза, заполняла медицинскую документацию, осуществляла динамическое наблюдение за пациентами. | [
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805 | Автором самостоятельно произведен сбор архивных данных, создание базы данных, также выполнена разработка дизайна исследования. | [
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806 | Непосредственно автором получены результаты исследования, представленные в диссертационной работе, выполнена их статистическая обработка с последующим анализом, систематизацией и сравнением с литературными данными. | [
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807 | Сформулированы выводы и разработаны практические рекомендации, внедренные в практику ГБУЗ «Самарский областной медицинский центр Династия», ГБУЗ СО «Самарская городская поликлиника № 3», Частного учреждения здравоохранения «Клиническая больница «РЖД – Медицина» г. Самары». | [
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808 | Несмотря на десятилетия изучения регуляции трансляции у бактерий, остаётся актуальным вопрос о том, что именно позволяет конкретной мРНК обеспечить быструю инициацию и эффективную трансляцию. | [
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809 | Данная работа посвящена изучению особенностей синтетических и природных 5'-нетранслируемых областей (5’-UTR) бактериальных мРНК, влияющих на эффективность трансляции, с помощью библиотек репортёрных конструкций. | [
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810 | Применение метода Flow-seq, сочетающего проточную цитометрию с последующим секвенированием нового поколения, позволило провести анализ in vivo для библиотек репортёрных конструкций из более 24,5 тысяч различных вариантов 5’-UTR и определить функциональную значимость отдельных их участков. | [
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811 | В итоге помимо всех известных детерминант, обеспечивающих увеличение уровня синтезируемого белка, определили ранее не описанные особенности 5’-UTR, способствующие увеличению эффективности трансляции: низкая доля остатков цитидина, AG-повторы, как новый энхансер трансляции, аддитивный эффект нескольких SD-мотивов, дополнительного старт-кодона. | [
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812 | Результаты представляют интерес с фундаментальной точки зрения, более подробно раскрывая особенности сложного процесса трансляции, и проливают новый свет на возможности регуляции уровня биосинтеза белка с практической точки зрения при решении задач биотехнологии. | [
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813 | Цель настоящего исследования - разработка научных и технологических основ изготовления металлических биполярных пластин для топливных элементов с протонобменной мембраной для мобильных систем энергопитания. | [
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814 | Разработаны конструктивные и технологические решения изготовления металлических биполярных пластин для топливного элемента с протонобменной мембраной для мобильных систем энергопитания мощностью до 1,5 кВт, в том числе: разработана и запатентована конструкция металлической БП, обеспечивающей эффективное снабжение каждого мембранно-электродного бока (МЭБ) - единичного топливного элемента - необходимым количеством топлива и окислителя, и обладающей достаточным запасом прочности и жесткости для создания электрического контакта и герметизации анодного пространства топливного элемента. | [
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815 | Подобраны и обоснованы технологические режимы обработки титана при изготовлении биполярных пластин. | [
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816 | Разработан способ формования каналов катодной части БП путем пошаговой деформации заготовки холодным способом, которая позволяет снизить критическое истончение материала и величину остаточных механических напряжений в нем. | [
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817 | Разработан и запатентован способ повышения коррозионной стойкости металлических биполярных пластин ПОМТЭ путем нанесения защитного покрытия на основе сложных олигомеров и полимеров, являющихся побочным продуктом переработки биомассы в 5-гидроксиметилфурфурол. | [
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818 | Исследовано влияние условий эксплуатации в широком диапазоне изменения параметров окружающей среды, реализация которых возможна при эксплуатации беспилотных летательных аппаратов (БПЛА), на электрические характеристики и стабильность работы батареи ПОМТЭ с открытым катодом. | [
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819 | Результаты диссертационного исследования использованы ООО НПП «Интор» при создании экспериментального образца технологической линии изготовления биполярных пластин для топливных элементов с протонобменной мембраной, предназначенных для энергообеспечения БПЛА. | [
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820 | Объект исследований – 128 коллекционных образцов ярового ячменя. | [
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] |
821 | Цель исследования – выделить источники для селекции ярового ячменя на основе оценки коллекционных образцов различного эколого-географического происхождения по урожайности и комплексу селекционно-ценных признаков. | [
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822 | Методики: «Методические указания по изучению мировой коллекции ячменя и овса» (2012) и Международный классификатор СЭВ рода Hordeum L. (1983), Кривченко В.И. | [
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824 | (2008), Родина Н.А., Ефремова З.Г. | [
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825 | (1986), Афанасенко О.С. | [
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826 | (2005), Тороп Е.А. | [
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827 | и др., (2011), Удовенко В.Г. | [
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828 | (1988), Лисицын Е.М. | [
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829 | (2003), Омаров Д.С. | [
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830 | (1975), В.А. | [
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831 | Зыкин и др. | [
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835 | (1973), Плохинский Н.А. | [
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836 | (1969). | [
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838 | Выявлены новые источники хозяйственно ценных признаков. | [
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] |
839 | Получены новые знания о закономерностях изменчивости и взаимосвязи селекционно-ценных признаков. | [
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840 | Создан новый исходный материал. | [
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841 | Выводы и предложения могут быть использованы в научных учреждениях, занимающихся селекцией. | [
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842 | Объект исследования: музейное дело в Омской области. | [
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843 | Цель работы: выявление закономерностей и особенностей процесса становления и развития музейного дела в Омской области с 1930-х до начала 1990-х гг. | [
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844 | Методы исследования: историко-сравнительный, историко-генетический, локально-исторический, историко-типологический. | [
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845 | Полученные результаты и новизна: привлечены разнообразные источники по истории и деятельности музеев, часть источников впервые вводится в научный оборот либо впервые привлекается к решению проблемы исторической реконструкции процесса развития музейного дела в Омской области; уточнен количественный и профильный состав музеев музейной сети, особенности ее формирования на разных этапах; выявлены и детализированы данные о возникновении тех или иных музеев; показана локальная специфика развития музейного дела в Омской области в 1930-х ? | [
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846 | начале 1990-х гг. | [
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847 | ; прослежены пути развития музейного дела с учетом влияния государственных и партийных структур разного уровня и личного вклада музейных сотрудников, общественных групп и энтузиастов музейного дела; систематизированы и обобщены источники и материалы по истории и основным направлениям музейной деятельности музеев Омской области; систематизированы и проанализированы статистические данные с количественными показателями обеспеченности музейными площадями, кадрами и по основным видам деятельности государственных музеев Омской области и их филиалов; реконструирован процесс формирования сети общественных музеев в Омской области с 1960-х гг. | [
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848 | до начала 1990-гг. | [
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849 | ; разработана целостная концепция формирования музейной сети и музейного дела региона. | [
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850 | Область применения: изучение региональной истории; разработка учебных курсов «История музейного дела России», «Грантовая деятельность в сфере культуры», «Менеджмент и маркетинг в музейной деятельности»; разработка экскурсий и музейных занятий, экскурсионных маршрутов. | [
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851 | В эксперименте разработан метод замещения дефекта белочной оболочки полового члена с применением децеллюляризированной трупной артерии. | [
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852 | В группах биомоделей было изучено влияние имплантированного графта децеллюляризированной трупной артерии на уровень С-реактивного белка в сыворотке крови (как маркера системного ответа). | [
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853 | В исследовании экспериментальным путем проведено сравнение разных видов сосудистых матриксов для пластики дефекта белочной оболочки полового члена. | [
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854 | Проведены исследования по двум направлениям, по первому направлению проведена оценка применимости децеллюляризированной трупной артерии человека в качестве материала для трансплантации. | [
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855 | Во втором направление изучалось свойство трупной артерии после криконсервации с позиций дальнейшего использования в качестве материала для трансплантации. | [
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856 | Полученные результаты свидетельствуют о потенциальной применимости децеллюляризированной трупной артерии в качестве материала аллотрансплантации. | [
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857 | Было установлено что применение децеллюляризированной трупной артерии человека снижает риски послеоперационных воспалительных и тромботических осложнений. | [
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858 | Установлено, что криоконсервация аллогенного сосудистого матрикса достоверно снижает сохранность коллагена I типа в биоматериале, ухудшает его биомеханические показатели (снижает значение модуля Юнга и предельного напряжения ). | [
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859 | Экспериментально доказано, что криоконсервация однократным замораживанием в 5% декстране 30000-40000, 7.5% альбумине человека и 10% DMSO с последующим хранением при температуре -80 С. Применение в качестве консервантов глицерина и пропандиола приводит к некрозам, появлению пикнотических ядер и разволокнению соединительнотканного матрикса. | [
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860 | Разработана и успешно апробирована в эксперименте модифицированная удлиняющая метолика хирургического лечения болезни Пейрони включающая иссечение бляшки и пластику дефекта децеллюляризированной трупной артерией человека. | [
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861 | Имплантированный графт из децеллюляризированной трупной артерии существенно не изменяет уровень С - реактивного белка в сыворотке (как маркера системного ответа ), а следовательно, не вызывает выраженного системного ответа. | [
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862 | При изучении морфологической трансформации децеллюляризированной трупной артерии после замещения дефекта белочной оболочки установлено, что последняя постепенно трансформируется в нормальную белочную оболочку, не вызывая фиброза. | [
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863 | Работа посвящена обоснованию и разработке педагогической модели скоростно-силовой подготовки юных баскетболистов 14-15 лет с использованием упражнений в парах с дополнительным отягощением. | [
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864 | Автором обоснованы факторы, определяющие необходимость использования упражнений в парах с дополнительным отягощением в процессе скоростно-силовой подготовки юных баскетболистов 14-15 лет. | [
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865 | Им установлены наиболее эффективные средства, методы и формы скоростно-силовой подготовки юных баскетболистов. | [
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866 | Обоснованы психолого-педагогические условия необходимые для применения упражнений в парах с дополнительным отягощением. | [
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867 | Экспериментально доказано высокая эффективность разработанной педагогической модели скоростно-силовой подготовки юных баскетболистов 14-15 лет с использованием упражнений в парах с дополнительным отягощением. | [
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868 | Цель исследования: Оптимизация восстановительного лечения пациентов с дисциркуляторной энцефалопатией III стадии пожилого и старческого возраста с применением когнитивного тренинга и низкочастотной импульсной магнитотерапии на фоне медикаментозной терапии. | [
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869 | Задачи исследования: 1. | [
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870 | Определить реабилитационный потенциал пациентов с дисциркуляторной энцефалопатией III стадии пожилого и старческого возраста на основе интегральной количественной оценки неврологического, интеллектуально-мнестического статуса, функциональной активности в повседневной жизни и критериев «Международной классификации функционирования, нарушений жизнедеятельности и здоровья». | [
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872 | Оценить влияние адаптированного когнитивного тренинга на неврологический статус, интеллектуально-мнестические функции, функциональную активность в повседневной жизни и реабилитационный потенциал больных старшей возрастной группы с дисциркуляторной энцефалопатией III стадии на фоне медикаментозной терапии. | [
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874 | Оценить влияние низкочастотной импульсной магнитотерапии и когнитивного тренинга на фоне медикаментозной терапии на неврологический статус, интеллектуально-мнестические функции, функциональную активность в повседневной жизни и реабилитационный потенциал больных старшей возрастной группы с дисциркуляторной энцефалопатией III стадии. | [
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876 | Дать сравнительную оценку эффективности комплексного применения когнитивного тренинга и низкочастотной импульсной магнитотерапии на фоне медикаментозной терапии у пациентов с дисциркуляторной энцефалопатией III стадии. | [
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878 | Проанализировать устойчивость лечебных эффектов комплексного применения когнитивного тренинга и низкочастотной импульсной магнитотерапии на фоне медикаментозной терапии пациентов с дисциркуляторной энцефалопатией III стадии через 3 месяца после лечения. | [
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879 | Выводы 1. | [
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881 | ведущие клинико-неврологические синдромы были представлены двигательными и когнитивными нарушениями в 100 %, психопатологическими расстройствами – в 91 %, псевдобульбарными – в 77%, пирамидными – в 75 %, атактическими – в 74 % и кохлеовестибулярными – в 58 %. | [
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882 | У пациентов с ДЭ III стадии неврологические и когнитивные расстройства были умеренной и тяжелой степени, функциональная активность в повседневной жизни, по данным шкалы IADL, была снижена до умеренного (50 %) и низкого (50 %) уровней. | [
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884 | Разработанный метод диагностики, включающий набор функциональных доменов МКФ и интегральную оценку неврологического, интеллектуально-мнестического статуса, повседневной активности пациентов, позволял оценить РП и влияние проводимой терапии у пациентов пожилого и старческого возраста с ДЭ III стадии. | [
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886 | На основе количественной оценки, детализации неврологического, интеллектуально-мнестического статуса и повседневной активности пациентов выявлено, что 50% пациентов с ДЭ III стадии имели РП среднего уровня, что предполагало возможность частичного восстановления нарушенных категорий жизнедеятельности. | [
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888 | Курсовое применение церебропротекторов (микроциркулянтов и ноотропов) у пациентов пожилого и старческого возраста с ДЭ III стадии не позволяло уменьшить когнитивные расстройства, но способствовало стабилизации интеллектуально-мнестических функций и неврологического статуса на протяжении шести месяцев. | [
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890 | Когнитивный тренинг в комплексе с медикаментозной профилактической терапией продолжительностью три месяца у пациентов с ДЭ III стадии пожилого и старческого возраста способствовал повышению кратковременной памяти в 1,8 раза и долговременной памяти - в 1,6 раза, при этом тяжесть неврологических нарушений снижалась на 13%, а функциональная активность в повседневной жизни повышалась на 26%. | [
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892 | Низкочастотная импульсная магнитотерапия в комплексе с КТ и медикаментозной профилактической терапией у пациентов с ДЭ III стадии способствовала улучшению кратковременной памяти в 1,5 раз, долговременной памяти в 1,8 раз, уменьшению выраженности неврологических нарушений на 19 % и повышению функциональной активности в повседневной жизни на 36 %. | [
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894 | При анализе отдаленных результатов у пациентов с ДЭ III стадии, получавших низкочастотную импульсную МТ, КТ и медикаментозную терапию, через три месяца показатели интеллектуально-мнестического и неврологического статуса не отличались от параметров после завершенного курса восстановительного лечения и по сравнению с исходными значениям повысились показатели кратковременной памяти на 79%, долговременной памяти на 85 %, функциональной активности в повседневной жизни на 36 %, неврологические расстройства уменьшились на 19%, при этом реабилитационный потенциал улучшился в 1,8 раз. | [
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895 | Через три месяца после курса КТ у пациентов с ДЭ III стадии достигнутые позитивные эффекты нивелировались: показатели кратковременной и долговременной памяти снизились на 89% и 66 % соответственно, ухудшились показатели неврологического статуса на 18%, функциональной независимости в повседневной активности - на 26%. | [
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896 | Объект исследования – процесс обучения стажёров из КНР публицистическому стилю речи с использованием интернет-ресурсов на занятиях по русскому языку как иностранному. | [
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897 | Цель исследования - разработать комплекс упражнений и методических приёмов для обучения публицистическому стилю речи китайских стажёров на занятиях по РКИ на основе применения современных русскоязычных интернет-ресурсов. | [
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898 | Теоретическая значимость исследования заключается в систематизации материалов в области публицистического регистра текстов, выведенных критериев отбора учебного материала для обучения публицистическому стилю речи с использованием интернет-ресурсов в курсе РКИ. | [
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899 | Практическая значимость настоящего исследования заключается в разработке комплекса упражнений и методических приёмов для обучения публицистическому стилю речи с использованием интернет-ресурсов в курсе РКИ. | [
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