Question: what kinds of complications related to COVID-19 are associated with diabetes

A study aimed to map COVID-19-related worries and overall psychosocial health among people with diabetes in Denmark during the initial pandemic phase. The survey of 2430 adult diabetic panel members revealed that over half were worried about being disproportionately affected by COVID-19 due to their diabetes, and one-third were concerned about being labeled as high-risk and struggling to manage diabetes if infected. Logistic regression analysis identified females, those with type

A study aimed to map COVID-19-related worries and overall psychosocial health among people with diabetes in Denmark. The survey of 2430 adults with diabetes revealed that over half were worried about being disproportionately affected by COVID-19 due to their diabetes, and one-third were concerned about being labeled as high-risk and struggling to manage diabetes if infected. Logistic regression analysis identified females, those with type 1 diabetes, diabetes complications

SARS-CoV-2, the virus causing COVID-19, has infected over 3.5 million people worldwide. Diabetes, age, and cardiovascular disease are identified as factors increasing the severity of COVID-19. Diabetic patients are more susceptible to complications in respiratory infections like SARS-CoV-2, as seen in previous outbreaks of SARS, MERS, and Influenza.

A meta-analysis was conducted to identify laboratory findings predicting a poor prognosis in COVID-19 patients with diabetes. Diabetes is a significant comorbidity associated with a poor clinical outcome and high mortality rate in COVID-19 patients. The study aimed to determine which laboratory parameters distinguish patients with COVID-19 and diabetes who recovered from those who experienced complications or died.

A study was conducted to identify risk factors for mortality in COVID-19 cases, specifically focusing on the role of diabetes and obesity. The data was obtained from the Mexican Ministry of Health and included demographic and health characteristics of confirmed, suspected, and negative COVID-19 cases. The study found an increased risk of SARS-CoV-2 positivity and mortality in those with diabetes, obesity, male subjects, and early-onset diabetes. R

A study identified risk factors for COVID-19 lethality in Mexico, including early-onset diabetes, obesity, COPD, advanced age, hypertension, immunosuppression, and CKD. Obesity was found to mediate 49.5% of the effect of diabetes on COVID-19 lethality. The study also developed a clinical score to predict COVID-19 lethality, including age ≥65 years

A study identified risk factors for COVID-19 lethality in Mexico, including obesity, diabetes, chronic obstructive pulmonary disease, advanced age, hypertension, immunosuppression, and chronic kidney disease. Obesity was found to mediate 49.5% of the effect of diabetes on COVID-19 lethality. The study developed a clinical score to predict COVID-19 lethality based on age, diabetes,

The COVID-19 pandemic and diabetes, a global epidemic, share a significant connection as individuals with diabetes face adverse outcomes if infected with COVID-19. A search using keywords "COVID-19" and "Diabetes" revealed that COVID-19 may cause complications in diabetes patients through an imbalance in ACE2 activation pathways, leading to an inflammatory response and acute β-cell dysfunction. Diabetes patients are at

The COVID-19 pandemic and diabetes, a global epidemic, share a significant connection as individuals with diabetes face adverse outcomes if infected with COVID-19. A search using keywords "COVID-19" and "Diabetes" revealed that COVID-19 may cause complications in diabetes patients through an imbalance in ACE2 activation pathways, leading to an inflammatory response and acute ß-cell dysfunction. Diabetes patients are at

Diabetes, a chronic disease linked to micro- and macrovascular complications and a major risk factor for cardiovascular disease, causes significant cardiovascular complications in diabetic patients. Sex-gender differences influence diabetes epidemiology, risk factors, and cardiovascular complications, necessitating distinct therapeutic approaches for managing diabetes-related cardiovascular issues in men and women. This review explores sex-gender differences affecting diabetes, focusing on cardiovascular complications,

The passage discusses the higher prevalence and mortality rate of diabetes patients hospitalized for COVID-19 compared to non-diabetes patients. The CORONADO study in France identified prognostic factors beyond old age, including increased body mass index and presence of comorbidities. Previous diabetic complications increase risk of death, but past glucose control had no independent influence on hospitalized diabetes patient outcomes. The use of RAAS blockers and

The passage discusses the higher prevalence and mortality rate of diabetes patients hospitalized for COVID-19 compared to non-diabetes patients. The CORONADO study in France and other reports from China and the US identified factors beyond old age that increase the risk of severe COVID-19 infection in diabetes patients, including increased body mass index and obesity. Previous diabetic complications also increase the risk of death, but the quality of past glucose control

During the COVID-19 epidemic in the South of France, the use of diabetes technology such as insulin pumps and continuous glucose monitoring helped prevent acute metabolic complications for patients with type 1 diabetes. Telemedicine care and structured education were facilitated through technology, while home care services provided additional support.

The COVID-19 pandemic poses a significant risk to people with diabetes and related comorbidities, increasing their likelihood of severe disease and death. Factors such as older age, multiple health conditions, hyperglycemia, cardiac injury, and severe inflammatory response contribute to poor outcomes. Maintaining optimal glycemic control and preventing disease spread are crucial. While most people with COVID-19 have mild symptoms, those with diabetes are at higher risk

The COVID-19 pandemic caused by SARS-CoV-2 has resulted in thousands of deaths and no effective treatments have been identified. Many patients with COVID-19 have comorbidities such as hypertension, diabetes, and cardiovascular diseases, which are associated with a chronic inflammatory state. Severe COVID-19 patients exhibit elevated levels of inflammatory markers, which are predictive of a poor prognosis. The authors

The COVID-19 pandemic poses significant risks and challenges for people with diabetes, increasing their vulnerability to severe disease and complications. Factors such as older age, multi-morbidity, hyperglycemia, cardiac injury, and severe inflammatory response predict poor outcomes. Mild illnesses are generally supportive, while various immunomodulatory and antiviral therapies are being investigated for severe cases. People with diabetes may also face challenges in

The passage discusses the potential of the Internet of Medical Things (IoMT) and smart home devices in revolutionizing home care for diabetic foot ulcers (DFUs), a costly and debilitating complication of diabetes. The authors reviewed literature and expert opinions from podiatry, engineering, and data security perspectives. IoMT enables patient engagement, personalized care, and data-driven treatment regimens, and recent advances in voice-activated commands technology offer new opportunities for

The Western Pacific Region reported 192,016 confirmed COVID-19 cases and 7,125 deaths as of June 8, 2020. People with diabetes face challenges in treating COVID-19 due to blood glucose fluctuations and comorbidities. National diabetes associations and governments are providing guidelines and medical supplies. The region's large size and diverse COVID-19 situations result in a varied pandemic profile. Creative measures like drive-

The World Health Organization declared a pandemic and reported 192,016 confirmed COVID-19 cases with 7125 deaths in the Western Pacific Region as of June 8, 2020. People with diabetes face challenges in treating COVID-19 due to blood glucose fluctuations and comorbidities. National associations and governments are providing guidelines and medical supplies for diabetic individuals. The Western Pacific Region's diverse countries and COVID-19 situations

During the COVID-19 lockdown in India, a study of 150 patients with type 2 diabetes found that 21% reported an increase in carbohydrate consumption, 23% snacked more frequently, 27% consumed more fruits, 42% exercised less, 19% gained weight, and 23% did self-monitoring of blood glucose less often. Additionally, 87% reported mental stress

This study aimed to investigate the phenotypic characteristics and prognosis of COVID-19 patients with diabetes. The analysis focused on 1,317 participants, most of whom were men with a mean age of 69.8 years and a predominance of type 2 diabetes. The primary outcome was a combination of tracheal intubation and death within 7 days of admission. In multivariable analyses, only BMI remained positively associated with

This study aimed to understand the phenotypic characteristics and prognosis of COVID-19 patients with diabetes. The analysis focused on 1,317 participants, most of whom were men with a mean age of 69.8 years and a predominance of type 2 diabetes. The primary outcome was a combination of tracheal intubation and death within 7 days of admission. In multivariable analyses, only BMI remained positively associated with

The passage discusses the limited evidence regarding the long-term reduction of microvascular and macrovascular complications in diabetes patients who undergo bariatric surgery compared to intensive medical therapy. While numerous studies have shown the effectiveness of bariatric surgery in diabetes remission and glycemic improvement, there is a need for high-quality studies to determine if it reduces long-term complications. The review provides background information on diabetes treatment and ongoing research on vascular outcomes

A study was conducted among 220 type II diabetes mellitus patients in Ethiopian hospitals to examine the impact of diabetic peripheral neuropathic pain on health-related quality of life using the SF-36 instrument. The results showed that patients with pain had poorer quality of life in all domains and summary scores. The largest difference was in the physical component summary score (9.3) and physical functioning domain (30). Pain intensity had a negative correlation

The passage discusses the increased risk of cardiovascular diseases (CVD) and diabetes mellitus (DM) complications in COVID-19 patients. Findings suggest that COVID-19 patients without prior CVD history can develop complications like myocardial injury, cardiomyopathy, and venous thromboembolism. The association between DM and severe COVID-19 complications is unclear, but markers like IL-1, IL

The COVID-19 pandemic poses unique challenges to diabetes care, with disproportionate impact on people with diabetes and higher rates of complications and death. In-patient services require specialist support for managing glycaemia, while outpatient services need reorganization for proactive care and use of telehealth and digital services. Prioritization of communicable vs non-communicable diseases and a reduced clinical workforce create challenges in clinical decision making. The pandemic may

The COVID-19 pandemic poses unique challenges to diabetes care, with disproportionate impact on people with diabetes and higher rates of complications and death. In-patient services require specialist support for managing glycaemia, while outpatient services need reorganization for proactive care and use of telehealth and digital services. Prioritization of communicable vs non-communicable diseases and reduced clinical workforce create challenges in clinical decision making. The pandemic may lead

Diabetes may not increase the risk of contracting COVID-19 but could lead to more severe symptoms if infected. Older patients with diabetes and co-morbidities are at higher risk for unfavorable outcomes. Poorly controlled diabetes can worsen infections and cause hyperglycemia-related complications. Patients should have sufficient diabetic supplies at home, regularly test blood glucose levels, and seek care for glycemic imbalance or infection signs

Diabetes may not increase the risk of contracting COVID-19 but could lead to a more severe illness. Proper diabetes management is crucial during infection, including having sufficient supplies, regular self-tests, and contacting a caregiver for glycemic imbalances or infection signs. Antidiabetic therapy may require adjustments, and insulin therapy could be necessary for persistent hyperglycemia in hospitalized patients.

A study using electronic health records from Michigan Medicine identified racial differences in COVID-19 outcomes and comorbidities. Blacks/African Americans had higher hospitalization and death rates. The study, a phenome-wide association study (PheWAS), examined 1,043 pre-existing conditions and their association with COVID-19 outcomes in 5,698 patients, stratified by race. Obesity, iron deficiency anemia,

During the COVID-19 crisis, people with diabetes face an increased risk of severe or fatal infections, with potential complications including respiratory failure and septic complications. The global prevalence of diabetes, affecting over 450 million people, makes this a significant vulnerable population. However, the complexity and heterogeneity of diabetes can make it difficult to generalize about patients. Some antidiabetic drugs, such as DPP4 inhibitors and GLP1 receptor

During the COVID-19 crisis, patients with diabetes, affecting over 450 million people worldwide, face a heightened risk of severe or fatal infections. The complexity of diabetes and its comorbidities make generalizations difficult. DPP4 inhibitors and GLP1 receptor agonists may have potential benefits in modulating viral entry and inflammatory cytokines during COVID-19 infection, but evidence is limited. Conversely, SGL

A study exploring the relationship between diabetes and the severity of COVID-19 suggests that comorbid diabetes may worsen the progression of the disease. However, the underlying mechanisms are unclear. A recent study on Middle East Respiratory Syndrome (MERS) sheds light on this issue, and this essay aims to introduce the report and related studies, and propose suggestions for further investigations into the impact of diabetes on COVID-19.

The COVID-19 pandemic poses significant challenges for managing patients with immune-mediated kidney diseases due to their compromised antiviral immunity. Hypertension, cardiovascular disease, diabetes, and older age increase the risk of severe morbidity and mortality from COVID-19. The Immunonephrology Working Group of the European Renal Association–European Dialysis and Transplant Association aims to provide recommendations for managing these patients based on available evidence

The COVID-19 pandemic poses significant challenges for managing patients with immune-mediated kidney diseases due to their compromised antiviral immunity. Hypertension, cardiovascular disease, diabetes, and older age increase the risk of severe morbidity and mortality from COVID-19. The Immunonephrology Working Group of the European Renal Association-European Dialysis and Transplant Association provides recommendations to minimize the risk of COVID-19 infection

The passage is a narrative review aiming to assess the risk, severity, mortality, glycemic control, and role of antidiabetic agents in patients with diabetes and COVID-19. A search was conducted in PubMed, MedRxiv, and Google Scholar databases until May 10, 2020. The results indicate a high prevalence of diabetes in COVID-19 patients, with a more severe form of the disease and increased mort

The passage is a narrative review summarizing the relationship between diabetes, COVID-19 severity and mortality, glycemic control, and the role of antidiabetic agents. The review found a high prevalence of diabetes in COVID-19 patients, with poorly controlled diabetes increasing the risk of severe disease and mortality. No data is currently available regarding the effect of antidiabetic agents on COVID-19. The authors recommend optimal glycemic control and increased

A retrospective study of 258 COVID-19 patients in Wuhan, China, found that those with diabetes had higher leucocyte and neutrophil counts, fasting blood glucose, serum creatinine, urea nitrogen, and creatine kinase isoenzyme MB levels at admission. Patients with diabetes were more likely to develop severe or critical disease conditions, require antibiotic therapy, non-invasive or invasive

A retrospective cohort study of 258 COVID-19 patients in Wuhan, China, found that those with diabetes had higher leucocyte and neutrophil counts, fasting blood glucose, serum creatinine, urea nitrogen, and creatine kinase isoenzyme MB levels at admission. Patients with diabetes were more likely to develop severe or critical disease conditions, require antibiotic therapy, non-invasive

The study aimed to investigate the clinical characteristics, laboratory findings, and HRCT features of 132 COVID-19 patients with diabetes in Wuhan, China, and explore risk factors for in-hospital death and complications. Patients with an admission glucose level of >11mmol/L were more likely to require ICU care, develop ARDS and acute cardiac injury, and had a higher death rate than those with an admission glucose level of

The study aimed to investigate the clinical characteristics, laboratory findings, and HRCT features of 132 COVID-19 patients with diabetes in Wuhan China, and to explore risk factors for in-hospital death and complications. Patients with an admission glucose level >11mmol/L were more likely to require ICU care, develop ARDS and acute cardiac injury, and had a higher death rate than those with an admission glucose level <1

This retrospective study investigated the clinical characteristics, radiographic and laboratory tests, complications, treatments, and outcomes of 208 hospitalized COVID-19 patients, 96 of whom had type 2 diabetes. Diabetes patients had a higher prevalence of hypertension, coronary heart disease, and chronic kidney disease. CT scans showed more ground-glass opacity and bilateral patchy shadowing in diabetes patients. Diabetes patients also had higher levels

In a retrospective cohort study of 258 COVID-19 patients in Wuhan, China, those with diabetes had higher rates of severe disease, complications, and mortality compared to patients without diabetes. Diabetes and high fasting blood glucose levels were associated with increased risk of death from COVID-19 after adjusting for potential confounders.

The COVID-19 pandemic poses a significant risk for people with diabetes, with a meta-analysis in China reporting a 9.7% prevalence of COVID-19 cases among diabetics and a two-fold increased risk of severe cases. Global confinement measures to prevent COVID-19 spread conflict with comprehensive diabetes care, which requires regular patient-provider interactions for education, prescriptions, and management of complications or mental health. Confinement also increases risks for unhealth

The COVID-19 pandemic poses a significant risk for people with diabetes, with a meta-analysis in China reporting a 9.7% prevalence of COVID-19 cases among diabetics and a two-fold increased risk of severe cases. Global confinement measures to prevent COVID-19 spread conflict with comprehensive diabetes care, which requires regular patient-provider interactions. Confinement also increases risks for unhealthy diets, decreased physical activity, mental health concerns, and

This retrospective study analyzed 904 COVID-19 patients, 136 of whom had diabetes, mostly type 2. Older age and elevated C-reactive protein were risk factors for higher mortality in diabetic patients. Insulin usage was associated with poor prognosis. No significant difference in clinical outcomes was found between patients using ACE inhibitors or angiotensin II type-I receptor blockers and those not using these medications. C

A type 1 diabetes patient experienced remission and hypoglycemia after using chloroquine for malaria prevention. Due to its immunomodulatory and potential hypoglycemic effects, chloroquine may be more commonly used during the COVID-19 pandemic. Diabetes patients taking chloroquine should be monitored for hypoglycemia, even after recovery.

A type 1 diabetes patient experienced hypoglycemia during chloroquine therapy for malaria in a malaria-endemic area. Chloroquine, which has immunomodulatory and hypoglycaemic effects, may be more commonly used during the COVID-19 pandemic. Diabetes patients undergoing chloroquine treatment should be monitored for hypoglycemia even after recovery.

This meta-analysis aimed to explore the relationship between diabetes and mortality in patients with COVID-19. The results showed a significant association with a pooled OR of 1.75 (95% CI 1.31-2.36; P = 0.0002), indicating that diabetes increases the mortality risk for COVID-19 patients. The findings were consistent across sensitivity analyses.

Approximately 29.1 million Americans currently have diabetes, a number projected to reach 48.3 million by 2050. Diabetes is a significant risk factor for complications during total joint arthroplasty, with hyperglycemia in the perioperative period also linked to increased complication risk. A proactive approach to preoperative screening, optimization, and glycemic control may improve outcomes, reduce complications, and

This retrospective study analyzed 904 COVID-19 patients, 136 of whom had diabetes, mostly type 2. Older age and elevated C-reactive protein were risk factors for higher mortality in diabetic patients. Insulin usage was associated with poor prognosis. No significant difference in clinical outcomes was found between patients using ACE inhibitors or angiotensin II type-I receptor blockers and those not using them. C-

Tropical countries are experiencing a significant increase in undiagnosed or poorly controlled type 2 diabetes, which increases the risk of various infectious diseases, including common and healthcare-associated infections, foot ulcers, and endemic diseases like tuberculosis, melioidosis, and dengue virus infection. The interaction between diabetes and infections in tropical countries requires further research, as data is scarce for most tropical infections and possible biological mechanisms. The rise in

This narrative review summarizes the current state of research on the intersection of COVID-19 and Type 1 Diabetes (T1D). The authors conducted a systematic search of the PubMed database up to May 31, 2020, and identified 18 relevant articles. These studies addressed the risk of contracting COVID-19 in T1D patients, the impact of COVID-19 on T1D development, outcomes for T1D patients with

A study found a positive correlation between the number of confirmed COVID-19 cases and the GDP at the prefectural level in Chinese Mainland as of February 2020. Cities with higher GDP had more confirmed cases during the epidemic spread.

The passage discusses the relationship between metabolic comorbidities, such as diabetes, obesity, and arterial hypertension, and the worsened prognosis of COVID-19. Obese individuals are more susceptible to infections and serve as a pathogen reservoir. Diabetic individuals have higher inflammatory processes due to constant glucose recognition. Hypertensive individuals, treated with ACE-inhibitors and ARBs

This passage discusses the risk factors for mortality in pregnant women with SARS-CoV-2 infection in the context of Mexico's high number of cases and deaths. Advanced age and co-morbidities such as diabetes, hypertension, and obesity increase the risk of adverse outcomes in COVID-19 infection for pregnant women. However, women are less likely to die or require hospitalization than men. The research letter focuses on evaluating the risk factors for

The study aimed to assess the impact of India's 21-day nationwide lockdown on glycemic control and diabetes-related complications. A simulation model was created using glycemic data from previous disasters and Indian database, and multivariate regression analysis was conducted. The model predicted a 2.26% increase in HBA1c from baseline after 30 days and a 3.68% increase after 45 days

The study aimed to assess the impact of India's 21-day nationwide lockdown on glycemic control and diabetes-related complications. A simulation model was created using glycemic data from previous disasters and Indian diabetes-related complications data. A multivariate regression analysis was conducted to analyze the relationship between lockdown duration and glycemic targets and complications. The model predicted a 2.26% increase in HBA1

The study of 174 COVID-19 patients found that those with diabetes were at higher risk for severe pneumonia, tissue injury, excessive inflammation, and hypercoagulable state. Diabetic patients also had significantly higher levels of inflammation-related biomarkers and coagulation index, indicating a greater susceptibility to an inflammatory response and rapid deterioration. Therefore, diabetes should be considered a risk factor for a rapid progression

The study of 174 COVID-19 patients found that those with diabetes were at higher risk for severe pneumonia, tissue injury, excessive inflammation responses, and hypercoagulable state. Diabetic patients also had significantly higher levels of inflammation-related biomarkers and coagulation index, indicating a greater susceptibility to an inflammatory storm and rapid deterioration of COVID-19. Therefore, diabetes should be considered a risk

A laparoscopic mini-gastric bypass surgery is a common treatment for morbid obesity and diabetes mellitus, and radiologists play a crucial role in postoperative evaluation. This passage provides an overview of the surgical technique, normal anatomy, and complications as seen on imaging examinations like fluoroscopy and CT scans.

This study aimed to assess the prevalence of pulmonary adverse drug effects (ADEs) in diabetic patients taking Angiotensin Converting Enzyme Inhibitors (ACEIs) or Angiotensin-II Receptor Blockers (ARBs) using data from the FDA. The results showed that Captopril had a statistically significantly higher incidence of pulmonary ADEs compared to other ACEIs and ARBs. The findings

This study aimed to assess the prevalence of pulmonary adverse drug effects (ADEs) in patients with diabetes taking Angiotensin-converting enzyme inhibitors (ACEIs) or Angiotensin II receptor blockers (ARBs), using data from the Food and Drug Administration. The results showed that captopril had a statistically significantly higher incidence of pulmonary ADEs compared to other ACEIs and ARBs. The

The COVID-19 pandemic, a major health crisis with devastating medical, economic, and social consequences, poses a serious risk for people with diabetes, elderly, and those with chronic and complicated diseases. The IDF MENA region has compiled data on the impact of COVID-19 on diabetes through medical and scientific publications and government responses. While diabetes is a high-risk factor for severe forms and mortality, the morbidity and mortality of COVID-19 with

The passage discusses the potential increase in diabetes cases and healthcare costs among older adults due to enforced inactivity during the COVID-19 lockdown. Using data from the Health Survey for England, the authors estimate that 2.1 million older adults in England could be pre-diabetic, and assuming a relative risk of diabetes from inactivity of 3.3 and 40% physical activity pre-lockdown, they calculate that 392,948 new

During the COVID-19 pandemic lockdown, hypoglycemia became a significant issue for people with type 2 diabetes mellitus due to limited access to food, clinics, pathological services, and medicines. A study of 146 patients who visited the emergency department with hypoglycemia symptoms found that most were male with an average age of 59.9 years and an average random blood glucose level of 57.

A systematic review aims to identify effective diabetes mellitus (DM) management practices for reducing symptoms and acute complications in palliative care patients. The review will search core health databases from 1990-2019 for relevant literature on adult DM treatment. Primary outcomes include symptoms (polyuria, polydipsia, polyphagia) and acute complications (hypoglycaemia, hyperglycaemic hyperosmolar

A cross-sectional study of 865 dialysis patients in Henan Province, China, found an overall incidence rate of 7.74/1000 catheter-days for all catheter complications, affecting 38.61% of patients. Catheter infections accounted for 10.58/1000 catheter-days and 56.65% of patients, catheter

A study was conducted to understand the molecular mechanisms linking diabetes as a comorbidity to severe COVID-19 in Emirati patients. Using a system genetics approach, the researchers identified the EXOC6/6B gene, which is involved in docking insulin granules to the plasma membrane, as having documented INDELs in 3 of 4 whole genome sequenced Emirati diabetic patients. Lower expression of EXOC6/6B was

Diabetes is a common comorbidity in COVID-19 patients, increasing the risk for severe and critical forms of the disease, leading to ICU admission and high mortality rates. Obesity, a risk factor for type 2 diabetes, is also more common in critical COVID-19 patients. COVID-19 can lead to poor glycemic control and increased risk of ketoacidosis in diabetic patients. There are no recommendations to stop antih

Diabetes is a common comorbidity in COVID-19 patients, but there's no evidence of increased risk of contracting the virus. However, diabetic patients are at risk for severe and critical forms of COVID-19, which require ICU admission and mechanical ventilation, with high mortality rates. Obesity, a risk factor for type 2 diabetes, is more common in critical COVID-19 patients. COVID-19 can lead to poor g

This review summarizes current knowledge on COVID-19 and pregnancy. The virus, which has been a global health issue since December 2019, has been linked to adverse pregnancy outcomes. The review aims to provide an overview of symptoms in pregnant women with COVID-19 and potential risks to fetuses and neonates. Data was extracted from studies published in English on Web of Science, Cochrane, PubMed, and Scopus up to April 2,

The passage is a review summarizing current knowledge about COVID-19 and its impact on pregnancy. The review covers early symptoms of COVID-19, which include fever, cough, dyspnea, myalgia, and fatigue, and less common symptoms such as sputum production, headache, hemoptysis, and diarrhea. There is no evidence of vertical maternal-fetal transmission of COVID-19. Pregnant women with COVID-1

This study investigates the role of glycoproteins in diabetes mellitus and their potential use as a therapeutic strategy. Glycoproteins are important for cell regulation, drug binding, and signaling pathways. Impaired glycoprotein metabolism contributes to diabetes mellitus. The study reviews relevant literature using keywords such as glycoprotein, diabetes mellitus, glycan, glycosylation, and

Diabetic nephropathy (DN), a complication of type 1 and 2 diabetes, causes end-stage renal disease in 30-40% of diabetic patients. Factors like hyperglycemia, hypertension, and proteinuria contribute to its progression. DN is diagnosed through blood urea nitrogen, serum creatinine, creatinine clearance, and proteinuria. Intensive control of hyper

The passage discusses the potential link between diabetes and COVID-19 infection and severity. While diabetes is known to increase the risk of serious COVID-19 events, it is unclear if diabetes itself increases the risk of contracting the virus. The use of DPP-4 inhibitors, a type of antidiabetic drug, in diabetic patients is related to the virus's infection mechanism, as DPP-4 is involved in virus entry into cells. The passage concl

A systemic review and meta-analysis of clinical data on COVID-19 patients identified preexisting chronic conditions like hypertension, cardiovascular disease, chronic kidney disease, and diabetes as risk factors for severe disease and increased mortality. Acute cardiac injury and acute kidney injury were also found to be strongly correlated with COVID-19-related mortality. Close monitoring of organ function is recommended for COVID-19 patients due to the high risk of

A review summarizing the second most common comorbidity of COVID-19 being diabetes, with epidemiological studies indicating this connection. The article aims to provide information on the prevalence, potential mechanisms, and management of diabetes in patients with COVID-19.

During the COVID-19 pandemic, routine health services have been reduced, and specialists have shifted to focus on COVID-19 cases. Obstetric assistance cannot be suspended, but safety measures are necessary. Changes in clinical habits are required to accommodate COVID-19 positive pregnant patients, who need additional care. This report details the management setup in an Obstetrics and Gynecology Unit at a University Hospital in Milan, Italy, during the COVID-19 era.

During the COVID-19 pandemic, obstetric assistance couldn't be suspended despite the need to reorganize the entire healthcare system. In Milan, Italy, a University Obstetrics and Gynecology Department adapted to ensure safety for pregnant patients, who require additional care if positive for COVID-19. Clinical habits were changed to address emerging needs.

A systematic review was conducted to examine the relationship between hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality. A search of 59,000 articles was conducted using an automated search engine, resulting in 54 articles for full review. Diabetes, hypertension, and high cholesterol were found to have an apparent relation to COVID-19 severity

Six male patients with COVID-19 presented to the Intensive Care Unit between March 20 and April 20, 2020, with combined diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Their median age was 50 years, and three were Hispanic and three African American. Hispanic patients had more severe acidosis and multiple comorbidities, and all cases were the

The passage discusses how older adults and those with comorbidities, such as hypertension, cardiovascular disease, diabetes, chronic respiratory disease, and chronic kidney disease, are at higher risk for severe outcomes and mortality from COVID-19 caused by the novel SARS-CoV-2 virus. Older adults in the US have a significant percentage of these conditions, increasing their risk of infection. Medications like angiotensin-converting

The COVID-19 pandemic is caused by the novel virus SARS-CoV-2, which leads to worse outcomes and higher mortality rates in older adults and those with comorbidities like hypertension, cardiovascular disease, diabetes, chronic respiratory disease, and chronic kidney disease. Many older adults have these conditions and are also taking medications such as ACE inhibitors and angiotensin II receptor blockers, which may upregulate the A

The passage discusses the background and aims of a study evaluating the outcome of hypertensive patients with COVID-19 and the relation to the use of renin-angiotensin system blockers (RASB). The study found that hypertension was present in approximately 21% of COVID-19 patients, followed by diabetes in nearly 11% and established cardiovascular disease in approximately 7%. While there is an emerging suggestion of increased mortality in

The passage discusses the background and aims of a study evaluating the outcome of hypertensive patients with COVID-19 and the relation to the use of renin-angiotensin system blockers (RASB). From ten Chinese studies with a total of 2209 patients, hypertension was present in approximately 21%, followed by diabetes in nearly 11%, and established cardiovascular disease in approximately 7%. The data suggests an increased mortality

The passage discusses the parallel impacts of COVID-19 and diabetes as global health crises. While efforts to mitigate COVID-19 have been swift, the response to diabetes has been more subdued. People with diabetes have experienced higher mortality and morbidity from COVID-19. The article shares experiences from an urban diabetes service in the UK, focusing on the impact on patients and healthcare providers, and potential lessons for the future.

The COVID-19 pandemic, which had claimed over 137,000 lives as of April 2020, has prompted the global scientific community to focus on containing and stopping its spread. This requires collaboration among researchers and practitioners in various fields, raising questions about research priorities, coordination, and involvement. In a comparative bibliometric study of six infectious disease outbreaks since 2000, including COVID-19, the present paper finds

A retrospective cohort study of 110 COVID-19 patients at a South Korean hospital found that those with diabetes mellitus (DM) were older and had higher blood pressure. DM patients also had higher levels of inflammation-related biomarkers and severity scores, and were more likely to experience severe and critical outcomes (SCO), including acute respiratory distress syndrome, septic shock, intensive care unit care, and 2

Three young patients with COVID-19 developed cerebral venous thrombosis within a 10-day period in early 2020. One patient had thrombosis in both superficial and deep systems, another in the straight sinus, vein of Galen, and internal cerebral veins, and a third in the deep medullary veins. Two patients had hemorrhagic venous infarcts. The median

A retrospective study evaluated early and mid-term outcomes of 43 complex abdominal hernia repairs using biological prostheses in France. Wound-related complications occurred in 17 patients, with smoking being the only identified risk factor. No prosthesis removal was necessary. Four hernia recurrences (9%) were observed, with a previous repair attempt and incomplete fascia closure being associated with recurrence. The use of bioprostheses enabled successful

A systematic review was conducted to examine the relationship between hypertension, diabetes, stroke, cancer, kidney issues, and high-cholesterol with COVID-19 disease severity. A search of 59,000 articles was reduced to 54 after filtering using keywords and questions. Diabetes, hypertension, and high cholesterol were found to have a relation to COVID-19 severity, but further research is needed for cancer

Diabetes mellitus, a chronic disease characterized by impaired glucose, fat, and protein metabolism, increases the risk of coronary artery disease and mortality. Comorbidities include obesity, hypertension, dyslipidemia, and kidney, nerve, and eye damage. Poorly controlled diabetes increases infection susceptibility and worsens symptoms. Since December 2019, COVID-19, caused by S

Diabetes mellitus, a chronic disease with impaired glucose, fat, and protein metabolism, increases the risk of coronary artery disease and infections. The comorbidities include obesity, hypertension, dyslipidemia, and kidney, nerve, and eye damage. Poorly controlled diabetes worsens infection symptoms. Since December 2019, COVID-19, caused by SARS-Co


Question: which biomarkers predict the severe clinical course of 2019-nCOV infection?

The passage reports on the clinical and biochemical characteristics of 12 patients infected with 2019-nCoV in Shenzhen, China, who all developed pneumonia and half of whom had acute respiratory distress syndrome (ARDS). Common laboratory abnormalities included hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes and neutrophils, elevated C-reactive protein and

The study identified the neutrophil-to-lymphocyte ratio (NLR) as an independent risk factor for severe illness in patients with 2019-nCoV infection. The NLR had a high predictive accuracy, as shown by a c-index of 0.807, well-fitting calibration curves, and positive decision and clinical impact curves. The incidence of severe illness was higher in patients with age ≥ 5

A novel coronavirus (2019-nCoV) from Wuhan, China, causing symptoms similar to SARS-CoV, is analyzed based on structural studies of SARS-CoV and its host receptor angiotensin-converting enzyme 2 (ACE2). The sequence of 2019-nCoV's receptor-binding domain (RBD) and its receptor-binding motif (RBM

A systematic review of 34 studies identified biomarkers including C-reactive protein, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, renal biomarkers, lymphocytes, and platelet count, which were significantly higher in patients with severe COVID-19 infections. Lymphocytes and

The passage discusses the role of the endothelium in the pathogenesis of Coronavirus Disease 2019 (COVID-19). The endothelium, a crucial part of blood vessel walls, may be involved in the disease's susceptibility and progression. The virus, which invades cells by binding to angiotensin-converting enzyme 2, can gain access to the systemic circulation by infecting or passing

The passage discusses the role of the endothelium in the pathogenesis of Coronavirus Disease 2019 (COVID-19). The endothelium, a crucial part of blood vessel walls, may be a linchpin in COVID-19 susceptibility and complications. The virus, which invades cells by binding to angiotensin-converting enzyme 2, can gain access to the systemic circulation by infect

Twenty-five children with confirmed COVID-19 infection in Chongqing were analyzed in this study. The median age was 11.0 years, and all cases were related to a family cluster outbreak or had a history in Hubei Province. The clinical types included 8 (32%) asymptomatic, 4 (16%) very mild, and 13 (52%) common cases. No severe or critical cases were identified. Common symptoms were cough and

Twenty-five children with confirmed 2019-nCoV infection in Chongqing were analyzed. The median age was 11.0 years, all were related to family clusters, and 7 had Hubei Province travel or residence history. Clinical types included 8 asymptomatic, 4 very mild, and 13 common cases. No severe or critical cases. Common symptoms were cough and fever. Normal white blood cell, CD4+ T l

Twenty-five children with confirmed 2019-nCoV infection in Chongqing were analyzed. The median age was 11.0 years, all were related to family clusters, and 7 had a history in Hubei Province. Clinical types included 8 asymptomatic, 4 very mild, and 13 common cases. No severe or critical cases were identified. Common symptoms were cough and fever. Lab results showed normal white blood cell, CD

The passage discusses the use of a deep learning algorithm, specifically the Virus Host Prediction (VHP) method, to identify potential hosts and infectivity patterns of the Wuhan 2019 Novel Coronavirus (2019-nCoV). The analysis suggests that 2019-nCoV shares close infectivity with other human coronaviruses such as SARS-CoV, Bat SARS-like Coronavir

The passage discusses the use of IL-2R/lymphocytes as potential markers for estimating the severity and predicting the clinical progression of COVID-19. In a study of 389 patients, it was found that leukocytes, neutrophils, infection biomarkers, and cytokine concentrations increased, while lymphocytes decreased with increased severity of illness. IL-2R was posit

The passage discusses the use of IL-2R/lymphocytes as potential markers for estimating the severity and predicting the clinical progression of COVID-19. In a study of 389 COVID-19 patients, it was found that leukocytes, neutrophils, infection biomarkers, and cytokine concentrations were increased, while lymphocytes were decreased with increased severity of illness.

A new coronavirus, named SARS-Cov-2, caused a pandemic outbreak in Wuhan, China, in December 2019. The disease, COVID-19, has brought new clinical and fundamental challenges to the medical community. The unique knowledge gained from studying immune-mediated inflammatory rheumatic diseases (IMIRDs) can help decipher the nature of COVID-19 complications and improve therapy. Patients with IMIR

The passage discusses a study using gene expression profiling on whole blood samples from advanced melanoma patients to identify potential biomarkers for immune-related gastrointestinal adverse events (GI irAEs) to ipilimumab treatment. The study involved 162 patients from two phase II clinical trials, with 49 patients developing grade 2+ GI irAEs. Differential gene expression was observed at baseline and over time, with most probe

A study was conducted using Italian genetic data from the Network of Italian Genomes (NIG) to identify ACE2 variants that may contribute to interindividual susceptibility and severity of COVID-19. Three missense changes and rare truncating variants were identified, which have not been reported in the Eastern Asia population and may interfere with protein cleavage, stabilization, and spike protein binding. These findings suggest that a predisposing genetic background may play

The 2019 novel Corona Virus (2019-nCoV) pandemic primarily affects the respiratory tract but also impacts neurological practice. Neurological manifestations, affecting about one-third of hospitalized individuals, include early symptoms like headache, dizziness, hyposmia, and hypogeusia, and late symptoms such as encephalopathy and stroke. Certain neurological conditions increase the risk of infection

This study investigates the relationship between meteorological conditions and the spread of the 2019-nCoV infection. The analysis of data from the 2019 outbreak in Wuhan and the 2003 SARS outbreak in China reveals that the virus survives best in temperatures between 13-24 degrees Celsius, with 19 degrees Celsius and 75% humidity being particularly conducive to its spread

A study used the SEIJR model with log-normal distributed time delay and Particle Swarm Optimization (PSO) to forecast the spread of 2019-nCov in Italy. The researchers estimated the early period average spreading velocity to be 0.330, with the first day of spread around February 1, 2020. After lockdown measures and public precautions, the spreading velocity decreased to 0.27

The passage is an analysis of 29 patients with 2019 novel coronavirus pneumonia, admitted to Tongji hospital. The study aimed to analyze the clinical characteristics and investigate the correlation between serum inflammatory cytokines and disease severity. The main symptoms were fever and respiratory symptoms, with normal or decreased white blood cell count, decreased lymphocyte count, increased hs-CRP, and normal procalcit

The passage is an analysis of 29 patients with 2019 novel coronavirus pneumonia, admitted to Tongji hospital. The objective was to analyze clinical characteristics and investigate the correlation between serum inflammatory cytokines and disease severity. The patients were divided into three groups: mild, severe, and critical. The main symptoms were fever and respiratory symptoms. Blood tests showed normal or decreased white blood cell count, decreased lymph

The passage is an analysis of 29 patients with 2019 novel coronavirus pneumonia, admitted to Tongji hospital. The study aimed to analyze the clinical characteristics and investigate the correlation between serum inflammatory cytokines and disease severity. The main symptoms were fever, respiratory and other systemic symptoms. Blood tests showed normal or decreased white blood cell count, decreased lymphocyte count, increased hs-CRP

The passage discusses the COVID-19 pandemic with over 413,000 confirmed cases and 18,000 deaths as of March 25, 2020. The Corona virus, specifically 2019-nCoV, causes severe respiratory infections through human and animal transmission. The virus binds to angiotensin converting enzyme 2 (ACE-2) and transmembrane ser

In this study, the authors analyzed the epidemiological and clinical characteristics of 99 patients diagnosed with 2019 novel coronavirus (2019-nCoV) pneumonia in Wuhan, China. The average age of the patients was 55.5 years, and 49% had a history of exposure to the Huanan seafood market. All patients were confirmed to have 2019-nCoV through real-time

In this study, the authors analyzed the epidemiological and clinical characteristics of 99 patients with 2019 novel coronavirus (2019-nCoV) pneumonia in Wuhan, China. The average age of the patients was 55.5 years, and 49% had a history of exposure to the Huanan seafood market. All patients were confirmed to have 2019-nCoV through real-time RT

COVID-19 is an infectious disease caused by 2019-nCoV, which shares similarities with SARS-CoV in terms of the receptor ACE2 and pathological findings. Both viruses target the lungs, vasculatures, and immune system, causing severe lung inflammation and immune deficiency due to an inappropriate immune response and over-production of cytokines. Treatment approaches include antiviral and anti-infl

COVID-19, caused by 2019-nCoV, is an atypical pneumonia with unknown pathogenesis. Similarities and differences between COVID-19 and SARS-CoV, which also targets lungs, vasculatures, and immune system, were examined. Both viruses use ACE2 receptor and cause severe lung inflammation and immune deficiency due to inappropriate immune response and over-production of cytokines

The passage discusses the use of a network-based model to predict the future spread of the 2019-nCoV virus in the Hubei province of China. The model consists of cities and their interactions, which must be inferred from the epidemic. The authors propose a method to predict the prevalence of the virus in each city using this network model and find that it is beneficial for accurate forecasting. The future course of the epidemic is uncertain, and these

The passage summarizes a study of three pregnant women infected with 2019-nCoV, all in their third trimester, who underwent emergency cesarean sections. The women presented with fever but no significant leukopenia or lymphopenia. Neonatal throat swabs were negative for 2019-nCoV. The women did not develop severe pneumonia or die by late February 2020. Plac

The passage summarizes a study investigating the clinical characteristics and placental pathology of three pregnant women infected with 2019-nCoV. All three women delivered in their third trimester via emergency cesarean section and presented with fever but no significant leukopenia or lymphopenia. Neonatal throat swabs were negative for 2019-nCoV. Two patients had been cured and discharged, while one was transferred

Three pregnant women with confirmed 2019-nCoV infection in their third trimester underwent emergency cesarean sections. All presented with fever but no significant leukopenia or lymphopenia. Neonatal throat swabs were negative for 2019-nCoV. None of the patients developed severe pneumonia or died by late February 2020. Placentas showed fibrin deposition and syncytial

The passage describes the clinical characteristics of 1,099 patients with laboratory-confirmed 2019 novel coronavirus (2019-nCoV) acute respiratory disease (ARD) in China. The median age was 47.0 years, and most patients were females. Few had contact with wildlife, but many had been to Wuhan or had contact with people from Wuhan. Fever and cough were the most common symptoms, and

A retrospective study was conducted to investigate the diagnostic value of IgM and IgG antibodies to 2019-nCoV in 2019-nCoV infection. Serum samples from 284 patients, including 205 2019-nCoV infected patients and 79 controls, were tested for 2019-nCoV antibodies using immunoassay technology. The

A new coronavirus, 2019-nCoV, identified in Wuhan, China, is closely related to SARS-CoV and MERS-CoV, and ACE2 may be a potential receptor for the virus. Actin protein and ibuprofen are suggested as potential therapeutic targets. Civets and poultry are potential natural reservoirs, and domain 288-330 of S1 protein from 2

A retrospective study of 45 elderly COVID-19 patients found a correlation between ferritin levels and lung ultrasound scoring systems (LUSS8 and LUSS12). Ferritin levels were significantly associated with both LUSS scores (p=0.001 for LUSS8 and p=0.002 for LUSS12). Using a threshold score of 15 for LUSS12 and

A young diabetic patient with COVID-19 infection showed ground-glass opacities and consolidations in both lungs on computed tomography scans. The patient improved clinically and on imaging after two weeks of treatment. Continuous monitoring through CT scans helped clinicians assess the disease progression or therapeutic effect.

The WHO's Situation Report 65 from March 25, 2020, reported 413,467 confirmed COVID-19 cases and 18,433 deaths. The virus, which causes severe respiratory infections in humans through drip and animal transmission, binds to ACE-2 and TMPRSS2. The disease's severity ranges from mild to severe, and there are no drugs that

Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrosing interstitial pneumonia of unknown cause with a poor prognosis. Serum biomarkers, including SP-A, SP-D, and KL-6, are less invasive and reproducible tools for monitoring clinical course and predicting prognosis. In Japan, these proteins are commonly used as serum markers for IPF. SP

A new coronavirus, 2019-nCoV, identified in Wuhan, China, is closely related to SARS-CoV and MERS-CoV, and ACE2, the known SARS-CoV receptor, may be a potential receptor for 2019-nCoV. Civets and poultry are suspected natural reservoirs, and domain 288-330 of S1 protein from

A retrospective study was conducted to identify risk factors for severe COVID-19 by comparing hemocyte counts and dynamic profiles in 141 confirmed COVID-19 patients. The study found that lymphopenia, neutrophilia, and thrombocytopenia were common in COVID-19 patients but more pronounced in severe cases. Multivariate Cox regression analysis identified neutrophil count, lymphocyte count, and

A systematic review of ongoing clinical trials was conducted to evaluate diagnostic and therapeutic interventions for the respiratory infection caused by the 2019 novel coronavirus (2019-nCoV). Seven trials were analyzed, targeting a total of 1350 patients. Interventions include lopinavir-ritonavir with aerosolized interferon-alpha, umifenovir, glucocorticoid, rib

The study identified fourteen cytokines that were significantly elevated in COVID-19 cases and showed different expression profiles in patients with different disease severity. IP-10, MCP-3, HGF, MIG, and MIP-1α were found to be highly associated with disease severity during disease progression, with remarkably higher expression levels in critically ill patients, followed by severe and then moderate patients. Serial detection of these cytokines in 1

A new approach was developed to quickly screen lineage B betacoronaviruses, such as SARS-CoV and 2019-nCoV, for their ability to infect human cells and use specific receptors. The study found that host protease processing during viral entry is a significant barrier for several lineage B viruses, but bypassing this barrier allows these viruses to enter human cells through an unknown receptor. The research also confirmed

The passage summarizes a meta-analysis of ten studies on the clinical characteristics of 50466 patients with 2019-nCoV infection. The most common symptoms were fever (89.1%) and cough (72.2%), while muscle soreness or fatigue (42.5%) and abnormal chest CT scans (96.6%) were also common. The incidence of severe cases was 18.1%, and

A study used the Molecule Transformer-Drug Target Interaction (MT-DTI) deep learning model to identify commercially available antiviral drugs that could act on the novel coronavirus (2019-nCoV) found in Wuhan, China. The top four drugs identified were atazanavir (Kd of 94.94 nM), efavirenz (199.17 nM), rit

The passage summarizes a study aiming to estimate the basic reproduction number of the Wuhan novel coronavirus (2019-nCoV) using the SEIR compartment model and reported cases. The estimated number falls between 2.8 and 3.3 based on Chinese reports and 3.2 to 3.9 based on international predictions. The authors conclude that the early transmission ability of 2019-nCoV is similar to or slightly higher

The passage aims to estimate the basic reproduction number of the Wuhan novel coronavirus (2019-nCoV) using the SEIR compartment model and reported cases. The results suggest a range of 2.8-3.3 based on real-time reports and 3.2-3.9 based on predicted cases. The authors conclude that 2019-nCoV's early transmission ability is similar to or slightly higher than SARS

A study using publication mining identified three pathways linking diabetes and COVID-19: dysregulation of Angiotensin-converting enzyme 2, liver dysfunction, and chronic systemic inflammation. Biomarkers predicting higher risk include hypertension, elevated Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. These biomarkers can be applied in clinical

A study using publication mining identified three pathways linking diabetes and COVID-19: an upregulation of Angiotensin-converting enzyme 2, liver dysfunction, and chronic systemic inflammation. Biomarkers predicting higher risk include hypertension, elevated Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. These biomarkers can be applied in

This study aimed to identify biomarkers for disease severity and progression of COVID-19 by analyzing the levels of 48 cytokines in plasma samples from 50 COVID-19 patients with different disease severity. The results showed that 14 cytokines were significantly elevated in COVID-19 cases, with IFN-Î³-induced protein 10, monocyte chemotactic protein-3, hepat

The study compared the clinical characteristics of 2019-nCoV infection in children and adults, finding differences in incubation period, symptoms, and lab results. Children had a longer incubation period, more diarrhea and vomiting, similar percentage of pneumonia, and more leukocytosis. Adults had more myalgia or fatigue, shorter incubation period, more leucopenia, and higher creatine kinase iso

A study identified four drugs with high binding capacity to the main protease of the 2019-nCoV virus, which is similar to the main protease of SARS-CoV and essential for the virus's life cycle. These drugs, which have been widely used in clinical applications and proven safe, may serve as promising candidates for treating 2019-nCoV infection. The study used high-throughput screening of 8,000

This study investigates the global prevalence and characteristics of three types of coronaviruses: 2019-nCoV, SARS-CoV, and MERS-CoV. SARS-CoV affected 8422 people and caused 916 deaths from November 2002 to August 2003. MERS-CoV spread to 27 states, causing 2496 cases and 8

This study investigates the global prevalence and characteristics of the novel coronavirus (2019-nCoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections. SARS-CoV affected 8422 people and caused 916 deaths from November 2002 to August

A webserver named D3Targets-2019-nCoV was developed to predict drug targets and identify lead compounds against COVID-19. It includes potential target proteins and their conformations from virus infection to replication and release, identifies all ligand-binding sites larger than 200 Å3 on a protein structure, and annotates correlation information among conformations or binding sites. The server is easily updated and accessible freely to the public, currently

The passage discusses the use of statistical methods and the SIR model to make preliminary predictions about the spread of coronavirus 2019-nCoV in mainland China. The authors estimate epidemic characteristics such as the numbers of infected, susceptible, and removed persons over time using available data and statistical approaches. They conclude that a simple mathematical model was used for these predictions, but further research is needed to update the predictions with new data and use more complex models.

The novel coronavirus, identified as SARS-CoV-2, caused the global outbreak of COVID-19, declared a pandemic by the World Health Organization on March 11, 2020. As of March 26, there were 462,684 confirmed cases and 20,834 deaths worldwide. The virus's spread dynamics are being studied using various models and parameters. As of the same date, Turkey reported

The study compares the sequence, structural, and antigenic differences between the spike glycoprotein of the 2019 novel coronavirus (2019-nCoV) and SARS coronavirus (SARS-CoV). The results suggest that 2019-nCoV is closely related to SARS-CoV, with a 12.8% difference in S protein and an 83.9

The COVID-19 virus, caused by SARS-CoV2, has been severe in elderly and those with underlying conditions like diabetes, heart disease, and chronic lung disease. Severe cases require intensive care and mechanical ventilation. No predictive biomarkers or preventative strategies exist. Severe COVID-19 has two aspects: viral overgrowth and excessive pulmonary inflammation. Clinical trials for viral overgrowth use remdesiv

A systematic review of 16 case reports on the 2019 novel coronavirus (2019-nCoV) pandemic, which has resulted in 68,279 deaths as of May 5, 2020, summarizes the transmission, pathology, clinical presentation, laboratory and imaging findings, and treatment in 2019-nCoV pneumonia. The disease is usually mild but can progress to severe pneum

Protein chip array profiling analysis identified serum amyloid A (SAA) protein as a potential biomarker for monitoring the extent of pneumonia in Severe Acute Respiratory Syndrome (SARS) patients. Nine increased and three decreased biomarkers were discovered in SARS patients compared to controls. SAA concentrations correlated well with the extent of pneumonia as assessed by chest x-ray opacity scores

The study uses Farr law, an epidemiology theory, to predict the daily incidence of novel coronavirus (2019-nCoV) in China, Hubei Province, and Wuhan City. The data was obtained from Chinese and Hubei health commission websites. The model, developed using data available on Feb. 8, 2020, shows that the daily incidence of 2019-nCoV in China and Hube

The study uses Farr's law to develop a model and predict the daily incidence of novel coronavirus (2019-nCoV) in China, Hubei Province, and Wuhan City. The model shows that the daily incidence has peaked but with different downward slopes. The model predicts that the daily incidence will drop to single-digits for China and Hubei Province by February 25, and for Wuhan city by March

A study using Farr's law to predict the daily incidence of novel coronavirus (2019-nCoV) in China, Hubei Province, and Wuhan City observed a peak in cases but different downward slopes. The model predicts a drop to single-digit daily incidence for China and Hubei Province by February 25 and for Wuhan city by March 8. However, there is a possibility of an upward trend in the

A webserver named D3Targets-2019-nCoV was developed to predict drug targets and identify lead compounds against COVID-19. It includes potential target proteins and their conformations from virus infection to replication and release, identifies all potential ligand-binding sites on protein structures with a volume larger than 200 Å, annotates correlation information among conformations or binding sites, and is easily updated and accessible freely to the public. The

The ongoing outbreak of SARS-CoV-2, the cause of COVID-19, poses a significant threat to global health with high morbidity and mortality, and no licensed vaccine or effective treatment is currently available. Repurposed drugs using existing antivirals have not been satisfactory and some have been toxic. The urgency for new interventions is heightened due to the time-consuming and expensive process of physical experimentation. Scientific simulations and data

The study aimed to evaluate the role of neutrophil to CD4+ lymphocyte ratio (NCD4LR) in predicting negative conversion time (NCT) of SARS-CoV-2 in COVID-19 patients. The results showed that high NCD4LR was associated with older age, more severe symptoms, higher inflammatory indicators, and longer NCT. Multivariate analysis identified NCD4LR as

A new coronavirus, 2019-nCoV, causing respiratory diseases and severe pneumonia, has been spreading since December 2019. Traditional SIR model-reliant epidemic forecasting has gained attention but overlooks 2019-nCoV's transmission characteristics, particularly undiagnosed cases. This paper introduces a SUIR model, an extension of the SIR model, with an additional state for Und

The passage discusses the variability in estimations of the basic reproduction number of the novel coronavirus (2019-nCoV) due to methodological issues and changing control strategies. Using updated data and refitting a transmission model, the authors estimate when the effective daily reproduction ratio fell below 1 and predict the peak of the epidemics, emphasizing the importance of persistent and strict self-isolation.

Nine children in Changsha, China, were identified as having novel coronavirus infection between January 8, 2019 and February 19, 2020. Six of these children had a family exposure and the median incubation period was 7.5 days. Initial symptoms were mild, including fever, diarrhea, cough, and sore throat, with two having no symptoms. Two children showed small ground-glass opacity on chest computed tomography

A study investigated the use of quantitative electroencephalography (qEEG) measures, specifically left temporoparietal cordance in the theta frequency band after one week of atomoxetine treatment, as a potential biomarker to predict response to atomoxetine in young adults with Attention-Deficit/Hyperactivity Disorder (ADHD). The results showed that cordance was associated with ADHD symptom improvement and quality of life in atomox

A study using online datasets found that Angiotensin Converting Enzyme 2 (ACE2), a major receptor for 2019-nCoV entry into human cells, highly expresses in renal tubular cells, Leydig cells, and cells in seminiferous ducts in the testis. This suggests that the virus may directly bind to these ACE2-positive cells and damage kidney and testicular tissue, leading to

The passage discusses the poor prognosis of severe malaria and the need for early parasite detection to prevent severe disease. While various clinical characteristics and lab tests have been used for early diagnosis, only a few are applicable in practice. The article highlights the potential of microRNAs (miRNAs) as biomarkers for severe malaria. Specific miRNAs, such as miR-451, miR-16, miR-12

A case of the 2019 novel coronavirus (2019-nCoV) was identified in the United States, marking the first confirmed case in the country. The patient initially presented with mild symptoms but developed pneumonia on day 9 of illness. This case underscores the importance of collaboration between healthcare professionals and public health authorities in addressing the spread of the virus and the need for swift sharing of clinical information.

A case of the 2019 novel coronavirus (2019-nCoV) was identified in the United States, marking the first confirmed case in the country. The patient initially presented with mild symptoms but developed pneumonia on day 9 of illness. This case underscores the importance of collaboration between healthcare professionals and public health authorities in managing the spread of the virus and the need for swift sharing of clinical information.

The passage is about a study comparing the clinical characteristics of 2019-nCoV infection in children and adults. The study reviewed medical records of 25 adult and 7 children confirmed cases. Children were all part of family clusters, while adults were divided into local residents, travelers, and those in direct contact with Wuhan residents. The median incubation period was shorter in adults (4 days) than children (5 days). Diarrhea and vomiting were

A new virus, 2019-nCoV, outbreak in Wuhan, China, requires an effective new drug due to its increasing severity. Previous research shows that SARS-CoV binds to human ACE2 through conformational changes in CTD1. Although there are mutations in 2019-nCoV, the binding energy to ACE2 remains high. Comparing the I-TASSER prediction model, the surface g

A new coronavirus, COVID-19 or Wuhan-2019-nCoV, is causing a global health emergency with over 65,000 infected and 1370 deaths as of February 14, 2020. Its infectivity exceeds that of previous coronaviruses, SARS and MERS, which caused 8000 and 2494 cases respectively between 2002-

The passage discusses the various coagulopathies associated with COVID-19, including disseminated intravascular coagulation, sepsis-induced coagulopathy, local microthrombi, venous thromboembolism, and arterial thrombotic complications. There is conflicting data on hematological and hemostatic derangements in COVID-19, with some suggesting a link to disease severity and mort

The passage discusses the identification of potential vaccine targets for the 2019-nCoV coronavirus through an in silico approach. The authors aligned the 2019-nCoV proteome to a database of viral immunogenic peptides and used predictive models to identify immunogenic peptides with binding potential to HLA alleles. They found 28 peptides identical to SARS-CoV, 4

A study identified potential vaccine targets for the 2019-nCoV coronavirus by aligning its proteome to a database of viral immunogenic peptides and predicting their immunogenicity and binding potential to HLA alleles using models and algorithms. The researchers found 28 identical peptides to SARS-CoV, 48 similar peptides to immunogenic peptides in The Immune Epitope Database

A study on H7N9 influenza patients found that angiotensin II plasma levels are significantly elevated and linked to disease severity and fatal outcomes. Angiotensin II levels are stronger predictors of mortality than C-reactive protein and some clinical parameters like the PaO2/FiO2 ratio. The findings suggest that angiotensin II is a potential biomarker for lethality in flu infections. Supplementary information is available online for

A meta-analysis of 21 studies with a total of 3377 patients and 33 laboratory parameters was conducted to evaluate the ability of hematologic, biochemical, and immunologic biomarkers in distinguishing severe and fatal forms of COVID-19 from non-severe and survivor cases. The results showed that patients with severe and fatal disease had significantly higher white blood cell counts and lower lymphocyte and platelet

A meta-analysis of 21 studies with a total of 3377 patients and 33 laboratory parameters was conducted to identify hematologic, biochemical, and immunologic biomarkers that can predict severe and fatal forms of COVID-19. The studies were divided into two cohorts: severity (severe vs. non-severe and mortality, i.e. non-survivors vs. survivors). Pat

A study was conducted to develop data mining models for predicting COVID-19 patient recovery using South Korea's epidemiological dataset. Six algorithms (decision tree, support vector machine, naive Bayes, logistic regression, random forest, and K-nearest neighbor) were applied using Python. The decision tree model had the highest accuracy (99.85%) for predicting patient recovery from COVID-19. The models predicted minimum and maximum recovery days, high

A study used Graph Neural Networks (GNN) to extract edge features and node features for node classification tasks related to SARS-CoV-2 infection and COVID-19 severity. The researchers created new edge features through self-supervised and unsupervised learning, and validated their method on two biological datasets of in vitro SARS-CoV-2 infection and human COVID-19 patients. The results showed better performance compared to Graph Attention Network

The passage predicts the potential spread of the 2019 novel coronavirus (2019-nCoV) in China using a simple mathematical model and epidemiological data. The authors found inconsistencies in the data and adjusted predictions accordingly. They estimate the number of cumulative cases to range from 76,000 to 230,000, with a peak of unrecovered infectives occurring in late February to early March. The number

A new coronavirus, COVID-19 or Wuhan-2019-nCoV, is causing a global health emergency with over 65,000 infected and 1370 deaths as of February 14, 2020. The virus is spreading faster than previous coronaviruses, SARS and MERS, which had 8000 and 2494 confirmed cases respectively. Differences in the rig

Ten neonates born to mothers with confirmed 2019-nCoV infection were analyzed for clinical features and outcomes. Mothers experienced symptoms before, during, or after delivery, with fever and cough being common. Neonates were mostly male, full-term, and had varying symptoms including shortness of breath, fever, thrombocytopenia, rapid heart rate, vomiting, and pneumothorax. Five have been discharged, one died

A case study was conducted to investigate the differential diagnosis of pulmonary infiltrates in cancer patients during the 2019 novel coronavirus (2019-nCoV) outbreak. Among 139 cancer patients who underwent chest CT scans before chemotherapy, eight (5.8%) had pulmonary infiltrates, five of whom had ground-glass opacities (GGOs). Three patients were tested for 20

A case study was conducted to investigate the differential diagnosis of pulmonary infiltrates in cancer patients during the 2019 novel coronavirus (2019-nCoV) outbreak. Among 139 cancer patients who underwent chest CT scans before chemotherapy, eight (5.8%) had pulmonary infiltrates, five of which were ground-glass opacities (GGOs). One patient, a 66-

A study was conducted to investigate the differential diagnosis of pulmonary infiltrates in cancer patients during the 2019 novel coronavirus (2019-nCoV) outbreak. The case of a 66-year-old man with non-Hodgkin lymphoma and pulmonary ground-glass opacities (GGOs) after chemotherapy was analyzed. The patient tested negative for 2019-nCoV