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README.md ADDED
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+ ---
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+ language: rna
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+ tags:
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+ - Biology
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+ - RNA
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+ license:
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+ - agpl-3.0
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+ size_categories:
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+ - 10K<n<100K
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+ source_datasets:
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+ - multimolecule/bprna
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+ - multimolecule/pdb
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+ task_categories:
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+ - text-generation
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+ - fill-mask
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+ task_ids:
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+ - language-modeling
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+ - masked-language-modeling
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+ pretty_name: RNAStrAlign
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+ library_name: multimolecule
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+ ---
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+
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+ # RNAStrAlign
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+
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+ RNAStrAlign is a comprehensive dataset of RNA sequences and their secondary structures.
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+
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+ RNAStrAlign aggregates data from multiple established RNA structure repositories, covering diverse RNA families such as 5S ribosomal RNA, tRNA, and group I introns.
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+
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+ It is considered complementary to the [ArchiveII](./archiveii) dataset.
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+
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+ ## Disclaimer
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+
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+ This is an UNOFFICIAL release of the RNAStrAlign by Zhen Tan, et al.
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+
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+ **The team releasing RNAStrAlign did not write this dataset card for this dataset so this dataset card has been written by the MultiMolecule team.**
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+
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+ ## Dataset Description
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+
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+ - **Homepage**: https://multimolecule.danling.org/datasets/rnastralign
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+ - **datasets**: https://huggingface.co/datasets/multimolecule/rnastralign
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+ - **Point of Contact**: [David H. Mathews](mailto:David_Mathews@urmc.rochester.edu) and [Gaurav Sharma](mailto:gaurav.sharma@rochester.edu)
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+
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+ ## Example Entry
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+
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+ | id | sequence | secondary_structure | family | subfamily |
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+ | -------------------------------- | ----------------------------------- | ------------------------------------ | ---------- | -------------- |
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+ | 16S_rRNA-Actinobacteria-AB002635 | ACACAUGCAAGCGAACGUGAUCUCCAGCUUGC... | .(((.(((..((..((((.(((((.((....)... | 16S_rRNA | Actinobacteria |
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+
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+ ## Column Description
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+
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+ - **id**:
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+ A unique identifier for each RNA entry. This ID is derived from the family and the original `.sta` file name, and serves as a reference to the specific RNA structure within the dataset.
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+
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+ - **sequence**:
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+ The nucleotide sequence of the RNA molecule, represented using the standard RNA bases:
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+
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+ - **A**: Adenine
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+ - **C**: Cytosine
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+ - **G**: Guanine
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+ - **U**: Uracil
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+
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+ - **secondary_structure**:
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+ The secondary structure of the RNA represented in dot-bracket notation, using up to three types of symbols to indicate base pairing and unpaired regions, as per bpRNA's standard:
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+
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+ - **Dots (`.`)**: Represent unpaired nucleotides.
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+ - **Parentheses (`(` and `)`)**: Represent base pairs in standard stems (page 1).
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+
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+ - **family**:
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+ The RNA family to which the sequence belongs, such as 16S rRNA, 5S rRNA, etc.
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+
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+ - **subfamily**:
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+ A more specific subfamily within the family, such as Actinobacteria for 16S rRNA.
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+
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+ Not all families have subfamilies, in which case this field will be `None`.
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+
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+ ## Variations
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+
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+ This dataset is available in two additional variants:
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+
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+ - [rnastralign](https://huggingface.co/datasets/multimolecule/rnastralign): The main RNAStrAlign dataset.
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+ - [rnastralign.512](https://huggingface.co/datasets/multimolecule/rnastralign.512): RNAStrAlign dataset with sequences no longer than 512 nucleotides.
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+ - [rnastralign.1024](https://huggingface.co/datasets/multimolecule/rnastralign.1024): RNAStrAlign dataset with sequences no longer than 1024 nucleotides.
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+
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+ ## Related Datasets
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+
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+ - [ArchiveII](https://huggingface.co/datasets/multimolecule/archiveii): A database of RNA secondary with the same families as RNAStrAlign, usually used for testing.
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+ - [bpRNA-spot](https://huggingface.co/datasets/multimolecule/bprna-spot): Another commonly used database in RNA secondary structures prediction.
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+
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+ ## License
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+
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+ This dataset is licensed under the [AGPL-3.0 License](https://www.gnu.org/licenses/agpl-3.0.html).
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+
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+ ```spdx
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+ SPDX-License-Identifier: AGPL-3.0-or-later
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+ ```
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+
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+ ## Citation
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+
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+ ```bibtex
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+ @article{ran2017turbofold,
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+ author = {Tan, Zhen and Fu, Yinghan and Sharma, Gaurav and Mathews, David H},
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+ journal = {Nucleic Acids Research},
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+ month = nov,
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+ number = 20,
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+ pages = {11570--11581},
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+ title = {{TurboFold} {II}: {RNA} structural alignment and secondary structure prediction informed by multiple homologs},
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+ volume = 45,
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+ year = 2017
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+ }
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+ ```
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