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siddharthtumre
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Revised-JNLPBA

Tasks:
Token Classification
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named-entity-recognition
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5
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ner_tags
sequence
1
[ "IL-2", "gene", "expression", "and", "NF-kappa", "B", "activation", "through", "CD28", "requires", "reactive", "oxygen", "production", "by", "5-lipoxygenase", "." ]
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[ "Activation", "of", "the", "CD28", "surface", "receptor", "provides", "a", "major", "costimulatory", "signal", "for", "T", "cell", "activation", "resulting", "in", "enhanced", "production", "of", "interleukin-2", "(", "IL-2", ")", "and", "cell", "proliferation", "." ]
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3
[ "In", "primary", "T", "lymphocytes", "we", "show", "that", "CD28", "ligation", "leads", "to", "the", "rapid", "intracellular", "formation", "of", "reactive", "oxygen", "intermediates", "(", "ROIs", ")", "which", "are", "required", "for", "CD28", "-mediated", "activation", "of", "the", "NF-kappa", "B", "/", "CD28-responsive", "complex", "and", "IL-2", "expression", "." ]
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4
[ "Delineation", "of", "the", "CD28", "signaling", "cascade", "was", "found", "to", "involve", "protein", "tyrosine", "kinase", "activity", ",", "followed", "by", "the", "activation", "of", "phospholipase", "A2", "and", "5-lipoxygenase", "." ]
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[ "Our", "data", "suggest", "that", "lipoxygenase", "metabolites", "activate", "ROI", "formation", "which", "then", "induce", "IL-2", "expression", "via", "NF-kappa", "B", "activation", "." ]
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[ "These", "findings", "should", "be", "useful", "for", "therapeutic", "strategies", "and", "the", "development", "of", "immunosuppressants", "targeting", "the", "CD28", "costimulatory", "pathway", "." ]
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[ "The", "peri-kappa", "B", "site", "mediates", "human", "immunodeficiency", "virus", "type", "2", "enhancer", "activation", "in", "monocytes", "but", "not", "in", "T", "cells", "." ]
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8
[ "Human", "immunodeficiency", "virus", "type", "2", "(", "HIV-2", ")", ",", "like", "HIV-1", ",", "causes", "AIDS", "and", "is", "associated", "with", "AIDS", "cases", "primarily", "in", "West", "Africa", "." ]
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9
[ "HIV-1", "and", "HIV-2", "display", "significant", "differences", "in", "nucleic", "acid", "sequence", "and", "in", "the", "natural", "history", "of", "clinical", "disease", "." ]
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10
[ "Consistent", "with", "these", "differences", ",", "we", "have", "previously", "demonstrated", "that", "the", "enhancer/promoter", "region", "of", "HIV-2", "functions", "quite", "differently", "from", "that", "of", "HIV-1", "." ]
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11
[ "Whereas", "activation", "of", "the", "HIV-1", "enhancer", "following", "T-cell", "stimulation", "is", "mediated", "largely", "through", "binding", "of", "the", "transcription", "factor", "NF-kappa", "B", "to", "two", "adjacent", "kappa", "B", "sites", "in", "the", "HIV-1", "long", "terminal", "repeat", ",", "activation", "of", "the", "HIV-2", "enhancer", "in", "monocytes", "and", "T", "cells", "is", "dependent", "on", "four", "cis-acting", "elements", ":", "a", "single", "kappa", "B", "site", ",", "two", "purine-rich", "binding", "sites", ",", "PuB1", "and", "PuB2", ",", "and", "a", "pets", "site", "." ]
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12
[ "We", "have", "now", "identified", "a", "novel", "cis-acting", "element", "within", "the", "HIV-2", "enhancer", ",", "immediately", "upstream", "of", "the", "kappa", "B", "site", ",", "designated", "peri-kappa", "B", "." ]
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[ "This", "site", "is", "conserved", "among", "isolates", "of", "HIV-2", "and", "the", "closely", "related", "simian", "immunodeficiency", "virus", ",", "and", "transfection", "assays", "show", "this", "site", "to", "mediate", "HIV-2", "enhancer", "activation", "following", "stimulation", "of", "monocytic", "but", "not", "T-cell", "lines", "." ]
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[ "This", "is", "the", "first", "description", "of", "an", "HIV-2", "enhancer", "element", "which", "displays", "such", "monocyte", "specificity", ",", "and", "no", "comparable", "enhancer", "element", "has", "been", "clearly", "defined", "for", "HIV-1", "." ]
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16
[ "Further", ",", "while", "specific", "constitutive", "binding", "to", "the", "peri-kappa", "B", "site", "is", "seen", "in", "monocytes", ",", "stimulation", "with", "phorbol", "esters", "induces", "additional", ",", "specific", "binding", "." ]
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[ "Understanding", "the", "monocyte-specific", "function", "of", "the", "peri-kappa", "B", "factor", "may", "ultimately", "provide", "insight", "into", "the", "different", "role", "monocytes", "and", "T", "cells", "play", "in", "HIV", "pathogenesis", "." ]
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[ "E1A", "gene", "expression", "induces", "susceptibility", "to", "killing", "by", "NK", "cells", "following", "immortalization", "but", "not", "adenovirus", "infection", "of", "human", "cells", "." ]
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[ "Adenovirus", "(", "Ad", ")", "infection", "and", "E1A", "transfection", "were", "used", "to", "model", "changes", "in", "susceptibility", "to", "NK", "cell", "killing", "caused", "by", "transient", "vs", "stable", "E1A", "expression", "in", "human", "cells", "." ]
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[ "Only", "stably", "transfected", "target", "cells", "exhibited", "cytolytic", "susceptibility", ",", "despite", "expression", "of", "equivalent", "levels", "of", "E1A", "proteins", "in", "Ad-infected", "targets", "." ]
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[ "The", "inability", "of", "E1A", "gene", "products", "to", "induce", "cytolytic", "susceptibility", "during", "infection", "was", "not", "explained", "by", "an", "inhibitory", "effect", "of", "viral", "infection", "on", "otherwise", "susceptible", "target", "cells", "or", "by", "viral", "gene", "effects", "on", "class", "I", "MHC", "antigen", "expression", "on", "target", "cells", "." ]
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22
[ "This", "differential", "effect", "of", "E1A", "expression", "on", "the", "cytolytic", "phenotypes", "of", "infected", "and", "stably", "transfected", "human", "cells", "suggests", "that", "human", "NK", "cells", "provide", "an", "effective", "immunologic", "barrier", "against", "the", "in", "vivo", "survival", "and", "neoplastic", "progression", "of", "E1A-immortalized", "cells", "that", "may", "emerge", "from", "the", "reservoir", "of", "persistently", "infected", "cells", "in", "the", "human", "host", "." ]
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23
[ "Distinct", "signaling", "properties", "identify", "functionally", "different", "CD4", "epitopes", "." ]
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[ "The", "CD4", "coreceptor", "interacts", "with", "non-polymorphic", "regions", "of", "major", "histocompatibility", "complex", "class", "II", "molecules", "on", "antigen-presenting", "cells", "and", "contributes", "to", "T", "cell", "activation", "." ]
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[ "We", "have", "investigated", "the", "effect", "of", "CD4", "triggering", "on", "T", "cell", "activating", "signals", "in", "a", "lymphoma", "model", "using", "monoclonal", "antibodies", "(", "mAb", ")", "which", "recognize", "different", "CD4", "epitopes", "." ]
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[ "Whereas", "different", "anti-CD4", "mAb", "or", "HIV-1", "gp120", "could", "all", "trigger", "activation", "of", "the", "protein", "tyrosine", "kinases", "p56lck", "and", "p59fyn", "and", "phosphorylation", "of", "the", "Shc", "adaptor", "protein", ",", "which", "mediates", "signals", "to", "Ras", ",", "they", "differed", "significantly", "in", "their", "ability", "to", "activate", "NF-AT", "." ]
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28
[ "Lack", "of", "full", "activation", "of", "NF-AT", "could", "be", "correlated", "to", "a", "dramatically", "reduced", "capacity", "to", "induce", "calcium", "flux", "and", "could", "be", "complemented", "with", "a", "calcium", "ionophore", "." ]
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29
[ "The", "results", "identify", "functionally", "distinct", "epitopes", "on", "the", "CD4", "coreceptor", "involved", "in", "activation", "of", "the", "Ras/protein", "kinase", "C", "and", "calcium", "pathways", "." ]
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[ "Ligand-dependent", "repression", "of", "the", "erythroid", "transcription", "factor", "GATA-1", "by", "the", "estrogen", "receptor", "." ]
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31
[ "High-dose", "estrogen", "administration", "induces", "anemia", "in", "mammals", "." ]
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32
[ "In", "chickens", ",", "estrogens", "stimulate", "outgrowth", "of", "bone", "marrow-derived", "erythroid", "progenitor", "cells", "and", "delay", "their", "maturation", "." ]
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33
[ "This", "delay", "is", "associated", "with", "down-regulation", "of", "many", "erythroid", "cell-specific", "genes", ",", "including", "alpha-", "and", "beta-globin", ",", "band", "3", ",", "band", "4.1", ",", "and", "the", "erythroid", "cell-specific", "histone", "H5", "." ]
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34
[ "We", "show", "here", "that", "estrogens", "also", "reduce", "the", "number", "of", "erythroid", "progenitor", "cells", "in", "primary", "human", "bone", "marrow", "cultures", "." ]
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35
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36
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37
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38
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[ "In", "coimmunoprecipitation", "experiments", "using", "transfected", "COS", "cells", ",", "GATA-1", "and", "ER", "associate", "in", "a", "ligand-dependent", "manner", "." ]
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[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
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[ "Mouse", "interleukin-2", "receptor", "alpha", "gene", "expression", "." ]
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[ "Interleukin-1", "and", "interleukin-2", "control", "transcription", "via", "distinct", "cis-acting", "elements", "." ]
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[ "The", "transcriptional", "response", "of", "the", "IL-2R", "alpha", "gene", "to", "stimulation", "by", "IL-1", "+", "IL-2", "is", "biphasic", "." ]
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48
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50
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