id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
901 | [
"Dexamethasone",
"may",
"be",
"superior",
"to",
"prednisone",
"in",
"conventional",
"equi-effective",
"doses",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
902 | [
"Blast",
"sensitivity",
"to",
"glucocorticoids",
"correlates",
"closely",
"with",
"sensitivity",
"to",
"other",
",",
"putatively",
"non-cross-resisting",
"agents",
"and",
"with",
"outcome",
"after",
"multi-agent",
"therapy",
",",
"suggesting",
"overlapping",
"mechanisms",
"of",
"action",
",",
"and",
"focusing",
"attention",
"on",
"the",
"determinants",
"of",
"the",
"threshold",
"for",
"apoptosis",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
903 | [
"Increasing",
"success",
"in",
"the",
"treatment",
"of",
"childhood",
"acute",
"lymphoblastic",
"leukemia",
"has",
"led",
"to",
"increasing",
"awareness",
"of",
"avascular",
"necrosis",
"of",
"bone",
"as",
"a",
"potentially",
"disabling",
"sequela",
"of",
"glucocorticoid",
"therapy",
",",
"especially",
"in",
"adolescent",
"and",
"young",
"adult",
"patients",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
904 | [
"Epstein-Barr",
"virus",
"nuclear",
"protein",
"2",
"transactivation",
"of",
"the",
"latent",
"membrane",
"protein",
"1",
"promoter",
"is",
"mediated",
"by",
"J",
"kappa",
"and",
"PU.1",
"."
] | [
9,
10,
10,
10,
10,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
9,
10,
0,
9,
0
] |
905 | [
"Expression",
"of",
"the",
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"latent",
"membrane",
"protein",
"1",
"(",
"LMP-1",
")",
"oncogene",
"is",
"regulated",
"by",
"the",
"EBV",
"nuclear",
"protein",
"2",
"(",
"EBNA-2",
")",
"transactivator",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
0
] |
906 | [
"EBNA-2",
"is",
"known",
"to",
"interact",
"with",
"the",
"cellular",
"DNA-binding",
"protein",
"J",
"kappa",
"and",
"is",
"recruited",
"to",
"promoters",
"containing",
"the",
"GTGGGAA",
"J",
"kappa",
"recognition",
"sequence",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
907 | [
"The",
"minimal",
"EBNA-2-responsive",
"LMP-1",
"promoter",
"includes",
"one",
"J",
"kappa-binding",
"site",
",",
"and",
"we",
"now",
"show",
"that",
"mutation",
"of",
"that",
"site",
",",
"such",
"that",
"J",
"kappa",
"can",
"not",
"bind",
",",
"reduces",
"EBNA-2",
"responsiveness",
"by",
"60",
"%",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0
] |
908 | [
"To",
"identify",
"other",
"factors",
"which",
"interact",
"with",
"the",
"LMP-1",
"EBNA-2",
"response",
"element",
"(",
"E2RE",
")",
",",
"a",
"-236/-145",
"minimal",
"E2RE",
"was",
"used",
"as",
"a",
"probe",
"in",
"an",
"electrophoretic",
"mobility",
"shift",
"assay",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
1,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
909 | [
"The",
"previously",
"characterized",
"factors",
"J",
"kappa",
",",
"PU.1",
",",
"and",
"AML1",
"bind",
"to",
"the",
"LMP-1",
"E2RE",
",",
"along",
"with",
"six",
"other",
"unidentified",
"factors",
"(",
"LBF2",
"to",
"LBF7",
")",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
9,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0
] |
910 | [
"Binding",
"sites",
"were",
"mapped",
"for",
"each",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0
] |
911 | [
"LBF4",
"is",
"B-",
"and",
"T-cell",
"specific",
"and",
"recognizes",
"the",
"PU.1",
"GGAA",
"core",
"sequence",
"as",
"shown",
"by",
"methylation",
"interference",
"."
] | [
9,
0,
7,
8,
8,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0
] |
912 | [
"LBF4",
"has",
"a",
"molecular",
"mass",
"of",
"105",
"kDa",
"and",
"is",
"probably",
"unrelated",
"to",
"PU.1",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
913 | [
"LBF2",
"was",
"found",
"only",
"in",
"epithelial",
"cell",
"lines",
",",
"whereas",
"LBF3",
",",
"LBF5",
",",
"LBF6",
",",
"and",
"LBF7",
"were",
"not",
"cell",
"type",
"specific",
"."
] | [
9,
0,
0,
0,
0,
5,
6,
6,
0,
0,
9,
0,
9,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
914 | [
"Mutations",
"of",
"the",
"AML1-",
"or",
"LBF4-binding",
"sites",
"had",
"no",
"effect",
"on",
"EBNA-2",
"transactivation",
",",
"whereas",
"mutation",
"of",
"the",
"PU.1-binding",
"site",
"completely",
"eliminated",
"EBNA-2",
"responses",
"."
] | [
0,
0,
0,
1,
0,
1,
2,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
9,
0,
0
] |
915 | [
"A",
"gst-EBNA-2",
"fusion",
"protein",
"specifically",
"depleted",
"PU.1",
"from",
"nuclear",
"extracts",
"and",
"bound",
"in",
"vitro",
"translated",
"PU.1",
",",
"providing",
"biochemical",
"evidence",
"for",
"a",
"direct",
"EBNA-2",
"-PU.1",
"interaction",
"."
] | [
0,
9,
10,
10,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
916 | [
"Thus",
",",
"EBNA-2",
"transactivation",
"of",
"the",
"LMP-1",
"promoter",
"is",
"dependent",
"on",
"interaction",
"with",
"at",
"least",
"two",
"distinct",
"sequence-specific",
"DNA-binding",
"proteins",
",",
"J",
"kappa",
"and",
"PU.1",
"."
] | [
0,
0,
9,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0
] |
917 | [
"LBF3",
",",
"LBF5",
",",
"LBF6",
",",
"or",
"LBF7",
"may",
"also",
"be",
"involved",
",",
"since",
"their",
"binding",
"sites",
"also",
"contribute",
"to",
"EBNA-2",
"responsiveness",
"."
] | [
9,
0,
9,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
918 | [
"Lymphocyte",
"glucocorticoid",
"receptor",
":",
"predictor",
"of",
"sertraline",
"response",
"in",
"adolescent",
"major",
"depressive",
"disorder",
"(",
"MDD",
")",
"."
] | [
7,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
919 | [
"Major",
"depressive",
"disorder",
"(",
"MDD",
")",
"in",
"adolescents",
"demonstrates",
"resistance",
"to",
"tricyclic",
"antidepressants",
"and",
"absence",
"of",
"hypercortisolemia",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
920 | [
"The",
"efficacy",
"of",
"serotonin",
"reuptake",
"inhibitors",
"(",
"SRIs",
")",
"is",
"uncertain",
",",
"and",
"response",
"predictors",
"are",
"unavailable",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
921 | [
"Abnormal",
"fast",
"feedback",
"and",
"negative",
"feedback",
"of",
"the",
"hypothalamic-pituitary-adrenal",
"axis",
"implicates",
"a",
"dampened",
"limbic-hippocampal",
"glucocorticoid",
"type",
"II",
"receptor",
"(",
"GCII",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0
] |
922 | [
"We",
"hypothesized",
"that",
"lymphocyte",
"GCII",
"is",
"altered",
"in",
"adolescent",
"MDD",
"and",
"could",
"serve",
"as",
"a",
"marker",
"for",
"response",
"to",
"SRIs",
"."
] | [
0,
0,
0,
7,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
923 | [
"In",
"an",
"open-label",
"study",
",",
"adolescents",
"(",
"n",
"=",
"20",
")",
"meeting",
"DSM-III-R",
"criteria",
"for",
"MDD",
"showed",
"baseline",
"lymphocyte",
"GCII",
"sites",
"per",
"cell",
"(",
"sites/cell",
")",
"values",
"of",
"793",
"+/-",
"106",
"versus",
"2",
",",
"563",
"+/-",
"499",
"(",
"+/-",
"SEM",
")",
"for",
"matched",
"controls",
"(",
"n",
"=",
"18",
")",
"(",
"t",
"=",
"3.5",
";",
"df",
"=",
"36",
";",
"p",
"<",
".001",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
924 | [
"GCII",
"was",
"bimodally",
"distributed",
",",
"with",
"SRI",
"responders",
"differing",
"from",
"nonresponders",
"(",
"t",
"=",
"3.9",
";",
"df",
"=",
"14",
";",
"p",
"<",
".001",
")",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
925 | [
"GCII",
"accurately",
"classified",
"90",
"percent",
"of",
"sertraline",
"responders",
"and",
"80",
"percent",
"of",
"nonresponders",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
926 | [
"Only",
"SRI",
"responders",
"showed",
"GCII",
"sites/cell",
"upregulated",
"after",
"6",
"weeks",
"of",
"treatment",
"(",
"t",
"=",
"2.1",
",",
"df",
"=",
"10",
";",
"p",
"<",
".05",
")",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
927 | [
"The",
"role",
"of",
"NFATp",
"in",
"cyclosporin",
"A-sensitive",
"tumor",
"necrosis",
"factor-alpha",
"gene",
"transcription",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
1,
2,
2,
2,
0,
0
] |
928 | [
"The",
"tumor",
"necrosis",
"factor-alpha",
"(",
"TNF",
"alpha",
")",
"gene",
"is",
"an",
"immediate",
"early",
"gene",
"in",
"activated",
"T",
"cells",
",",
"in",
"that",
"it",
"is",
"rapidly",
"induced",
"without",
"a",
"requirement",
"for",
"protein",
"synthesis",
"."
] | [
0,
1,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
929 | [
"Maximal",
"induction",
"of",
"TNF",
"alpha",
"mRNA",
"can",
"be",
"induced",
"by",
"treatment",
"of",
"T",
"cells",
"with",
"calcium",
"ionophores",
"alone",
",",
"via",
"a",
"calcineurin",
"-dependent",
"process",
"that",
"is",
"blocked",
"by",
"cyclosporin",
"A",
"."
] | [
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
930 | [
"We",
"have",
"previously",
"identified",
"a",
"promoter",
"element",
",",
"kappa",
"3",
",",
"that",
"is",
"required",
"for",
"calcium-stimulated",
",",
"cyclosporin",
"A-sensitive",
"induction",
"of",
"the",
"TNF",
"alpha",
"gene",
"in",
"activated",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
7,
8,
0
] |
931 | [
"Here",
",",
"we",
"demonstrate",
"that",
"the",
"kappa",
"3",
"binding",
"factor",
"contains",
"NFATp",
",",
"a",
"cyclosporin-sensitive",
"DNA-binding",
"protein",
"required",
"for",
"interleukin-2",
"gene",
"transcription",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0
] |
932 | [
"NFATp",
"binds",
"to",
"two",
"sites",
"within",
"the",
"kappa",
"3",
"element",
",",
"and",
"occupancy",
"of",
"both",
"sites",
"is",
"required",
"for",
"TNF",
"alpha",
"gene",
"induction",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0
] |
933 | [
"Thus",
",",
"although",
"the",
"kappa",
"3",
"element",
"has",
"little",
"sequence",
"similarity",
"to",
"other",
"NFATp-binding",
"sites",
",",
"it",
"appears",
"to",
"function",
"as",
"a",
"cyclosporin-sensitive",
"promoter",
"element",
"in",
"T",
"cells",
"by",
"virtue",
"of",
"its",
"ability",
"to",
"bind",
"NFATp",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
934 | [
"The",
"involvement",
"of",
"NFATp",
"in",
"transcriptional",
"activation",
"of",
"both",
"the",
"interleukin-2",
"and",
"TNF",
"alpha",
"genes",
"suggests",
"that",
"this",
"factor",
"plays",
"an",
"important",
"role",
"in",
"the",
"coordinate",
"induction",
"of",
"multiple",
"cytokine",
"genes",
",",
"starting",
"at",
"the",
"earliest",
"stages",
"of",
"T",
"cell",
"activation",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
935 | [
"Regulation",
"and",
"specificity",
"of",
"MNDA",
"expression",
"in",
"monocytes",
",",
"macrophages",
",",
"and",
"leukemia/B",
"lymphoma",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
7,
0,
7,
0,
0,
5,
6,
6,
6,
0
] |
936 | [
"The",
"expression",
"of",
"the",
"human",
"myeloid",
"cell",
"nuclear",
"differentiation",
"antigen",
"(",
"MNDA",
")",
"was",
"observed",
"specifically",
"in",
"cells",
"of",
"the",
"granulocyte-macrophage",
"lineage",
"in",
"our",
"earlier",
"reports",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0
] |
937 | [
"The",
"specificity",
"of",
"MNDA",
"expression",
"for",
"cells",
"in",
"the",
"granulocyte-macrophage",
"lineage",
"was",
"reexamined",
"in",
"cell",
"lines",
"established",
"from",
"patients",
"with",
"Philadelphia",
"chromosome-positive",
"chronic",
"myeloid",
"leukemia",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
938 | [
"Cell",
"lines",
"that",
"expressed",
"MNDA",
"exhibited",
"myeloid",
"cell",
"features",
"and",
"granulocyte",
"or",
"monocyte",
"differentiation",
"could",
"be",
"induced",
"in",
"vitro",
",",
"while",
"cell",
"lines",
"exhibiting",
"properties",
"of",
"very",
"early",
"stage",
"cells",
"or",
"multipotential",
"cells",
"did",
"not",
"express",
"MNDA",
"."
] | [
0,
0,
0,
0,
9,
0,
7,
8,
0,
0,
7,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
939 | [
"Cells",
"originating",
"from",
"cases",
"of",
"Burkitt",
"'s",
"lymphoma",
"were",
"negative",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
940 | [
"By",
"contrast",
",",
"three",
"lymphoblastoid",
"cell",
"lines",
"(",
"immortalized",
"in",
"vitro",
"with",
"Epstein-Barr",
"virus",
")",
"were",
"weakly",
"positive",
"and",
"MNDA",
"was",
"up-regulated",
"by",
"interferon-alpha",
"(",
"IFN-alpha",
")",
"treatment",
"."
] | [
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
9,
0,
0,
0
] |
941 | [
"As",
"we",
"reported",
"previously",
",",
"MNDA",
"mRNA",
"level",
"in",
"adherent",
"monocytes",
"is",
"elevated",
"by",
"IFN-alpha",
";",
"in",
"this",
"study",
",",
"we",
"further",
"assessed",
"MNDA",
"expression",
"in",
"in",
"vitro",
"monocyte-derived",
"macrophages",
"."
] | [
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
7,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
7,
0
] |
942 | [
"Three",
"additional",
"agents",
"(",
"endotoxin",
",",
"phytohemagglutinin",
",",
"and",
"phorbol",
"ester",
")",
"and",
"other",
"conditions",
"that",
"affect",
"function",
",",
"cytokine",
"production",
",",
"differentiation",
",",
"and/or",
"growth",
"of",
"monocytes",
"were",
"examined",
"for",
"their",
"ability",
"to",
"alter",
"MNDA",
"expression",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
943 | [
"The",
"results",
"varied",
"with",
"the",
"agent",
",",
"cell",
"type",
",",
"and",
"stage",
"of",
"differentiation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
944 | [
"Changes",
"in",
"MNDA",
"expression",
"occurred",
"slowly",
"(",
"hours",
"to",
"days",
")",
",",
"suggesting",
"that",
"MNDA",
"could",
"mediate",
"changes",
"realized",
"over",
"a",
"long",
"period",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
945 | [
"The",
"results",
"also",
"reveal",
"a",
"discordance",
"in",
"certain",
"MNDA",
"positive",
"cells",
"between",
"steady-state",
"levels",
"or",
"changes",
"in",
"levels",
"of",
"protein",
"and",
"mRNA",
"indicating",
"that",
"the",
"regulation",
"of",
"MNDA",
"expression",
"occurs",
"at",
"more",
"than",
"one",
"point",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
946 | [
"Changes",
"in",
"MNDA",
"expression",
"are",
"consistent",
"with",
"a",
"role",
"in",
"opposing",
"macrophage",
"differentiation",
"and",
"activation",
"of",
"monocytes",
"/macrophages",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
7,
8,
0
] |
947 | [
"DNA-binding",
"studies",
"of",
"the",
"Epstein-Barr",
"virus",
"nuclear",
"antigen",
"2",
"(",
"EBNA-2",
")",
":",
"evidence",
"for",
"complex",
"formation",
"by",
"latent",
"membrane",
"protein",
"gene",
"promoter-binding",
"proteins",
"in",
"EBNA-2-positive",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0
] |
948 | [
"The",
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"nuclear",
"antigen",
"2",
"(",
"EBNA-2",
")",
"protein",
"is",
"essential",
"for",
"the",
"immortalization",
"of",
"human",
"primary",
"B",
"cells",
"by",
"EBV",
"."
] | [
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0
] |
949 | [
"EBNA-2",
"trans-activates",
"cellular",
"and",
"viral",
"genes",
"like",
"CD23",
",",
"c-fgr",
",",
"latent",
"membrane",
"protein",
"1",
"(",
"LMP1",
")",
"and",
"terminal",
"protein",
"1",
"(",
"TP1",
")",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
9,
10,
10,
10,
0,
9,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
950 | [
"Trans-activation",
"of",
"the",
"TP1",
"promoter",
"and",
"of",
"the",
"BamHI",
"C",
"promoter",
"has",
"already",
"been",
"investigated",
"in",
"detail",
"and",
"appears",
"to",
"be",
"mediated",
"via",
"protein-protein",
"interactions",
"and",
"not",
"by",
"direct",
"binding",
"of",
"EBNA-2",
"type",
"A",
"(",
"of",
"EBV",
"type",
"1",
")",
"to",
"the",
"DNA",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
951 | [
"EBNA-2",
"is",
"able",
"to",
"trans-activate",
"the",
"expression",
"of",
"the",
"LMP",
"gene",
"in",
"several",
"cell",
"lines",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0
] |
952 | [
"Various",
"reports",
"have",
"delineated",
"the",
"cis-acting",
"elements",
"of",
"the",
"LMP",
"promoter",
"through",
"which",
"EBNA-2",
"mediates",
"trans-activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
9,
0,
0,
0
] |
953 | [
"To",
"determine",
"whether",
"EBNA-2",
"also",
"trans-activates",
"the",
"LMP",
"promoter",
"by",
"protein-protein",
"interactions",
",",
"we",
"performed",
"a",
"series",
"of",
"gel",
"retardation",
"assays",
"and",
"competition",
"experiments",
"with",
"LMP",
"promoter",
"fragments",
"of",
"different",
"sizes",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0
] |
954 | [
"We",
"determined",
"that",
"the",
"protein-binding",
"region",
"on",
"the",
"LMP",
"promoter",
"was",
"within",
"a",
"42",
"bp",
"fragment",
"encompassing",
"nucleotides",
"-135",
"to",
"-176",
"relative",
"to",
"the",
"LMP",
"transcriptional",
"start",
"site",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
955 | [
"None",
"of",
"the",
"DNA",
"fragments",
"investigated",
"indicated",
"interaction",
"of",
"EBNA-2",
"with",
"the",
"DNA",
"via",
"protein-protein",
"interactions",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
956 | [
"No",
"significant",
"differences",
"between",
"EBNA-2",
"-positive",
"and",
"EBNA-2",
"-negative",
"nuclear",
"extracts",
"could",
"be",
"seen",
"in",
"the",
"gel",
"retardation",
"assay",
"under",
"conditions",
"that",
"clearly",
"showed",
"binding",
"of",
"EBNA-2A",
"to",
"the",
"TP1",
"promoter",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
1,
2,
0
] |
957 | [
"However",
",",
"analysis",
"of",
"sucrose",
"gradient",
"fractions",
"in",
"the",
"gel",
"retardation",
"assay",
"provided",
"evidence",
"that",
"the",
"LMP",
"promoter-binding",
"proteins",
"form",
"a",
"complex",
"of",
"higher",
"M",
"(",
"r",
")",
"in",
"EBNA-2-positive",
"cell",
"extracts",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
958 | [
"These",
"complexes",
"were",
"destroyed",
"by",
"detergent",
"."
] | [
0,
0,
0,
0,
0,
0,
0
] |
959 | [
"We",
"deduce",
"from",
"these",
"results",
"that",
"EBNA-2-positive",
"cells",
"might",
"indeed",
"contain",
"specific",
"complexes",
"bound",
"to",
"the",
"LMP",
"promoter",
"which",
"are",
",",
"however",
",",
"too",
"labile",
"to",
"be",
"detected",
"in",
"a",
"standard",
"gel",
"retardation",
"assay",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
960 | [
"Simultaneous",
"activation",
"of",
"Ig",
"and",
"Oct-2",
"synthesis",
"and",
"reduction",
"of",
"surface",
"MHC",
"class",
"II",
"expression",
"by",
"IL-6",
"."
] | [
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
9,
0
] |
961 | [
"Terminal",
"differentiation",
"of",
"B",
"cells",
"to",
"plasma",
"cells",
"in",
"vivo",
"is",
"characterized",
"by",
"secretion",
"of",
"Ig",
"and",
"extinction",
"of",
"MHC",
"class",
"II",
"expression",
"on",
"the",
"cell",
"surface",
"."
] | [
0,
0,
0,
7,
8,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0
] |
962 | [
"We",
"show",
"that",
"IL-6",
"signaling",
"leads",
"to",
"marked",
"increases",
"in",
"the",
"synthesis",
"and",
"secretion",
"of",
"Ig",
"in",
"clonal",
"human",
"B",
"cell",
"lines",
"and",
"newly",
"isolated",
"polyclonal",
"B",
"lymphocytes",
"in",
"vitro",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
7,
8,
0,
0,
0
] |
963 | [
"The",
"IL-6-induced",
"cells",
"resemble",
"plasma",
"cells",
"in",
"ultrastructure",
"and",
"in",
"reduced",
"expression",
"of",
"surface",
"MHC",
"class",
"II",
"."
] | [
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
964 | [
"Enhanced",
"Ig",
"synthesis",
"is",
"a",
"result",
"of",
"coordinated",
"transcriptional",
"activation",
"of",
"Ig",
"genes",
"without",
"promoter",
"or",
"isotype",
"specificity",
",",
"and",
"differential",
"accumulation",
"of",
"the",
"mRNA",
"encoding",
"the",
"secreted",
"form",
"of",
"Ig",
"heavy",
"chain",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
965 | [
"It",
"is",
"saturable",
"and",
"subject",
"to",
"negative",
"control",
"when",
"IL-6",
"stimulation",
"is",
"prolonged",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0
] |
966 | [
"Coordinate",
"with",
"temporal",
"changes",
"in",
"Ig",
"synthesis",
",",
"the",
"DNA-binding",
"activity",
"and",
"the",
"synthesis",
"of",
"the",
"B",
"cell-enriched",
"transcription",
"factor",
"Oct-2",
"are",
"regulated",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0
] |
967 | [
"Thus",
",",
"differentiation",
"of",
"B",
"cells",
"with",
"IL-6",
"in",
"vitro",
"recapitulates",
"the",
"hallmarks",
"of",
"terminal",
"B",
"differentiation",
"in",
"vivo",
";",
"Oct-2",
"may",
"have",
"a",
"role",
"in",
"this",
"process",
"."
] | [
0,
0,
0,
0,
7,
8,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
968 | [
"T-cell",
"functional",
"regions",
"of",
"the",
"human",
"IL-3",
"proximal",
"promoter",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] |
969 | [
"The",
"human",
"interleukin-3",
"(",
"IL-3",
")",
"gene",
"is",
"expressed",
"almost",
"exclusively",
"in",
"activated",
"T",
"cells",
"."
] | [
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
970 | [
"Its",
"expression",
"is",
"regulated",
"at",
"both",
"the",
"transcriptional",
"and",
"post-transcriptional",
"level",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
971 | [
"We",
"have",
"previously",
"shown",
"that",
"treatment",
"of",
"Jurkat",
"T",
"cells",
"with",
"phytohemaglutinin",
"(",
"PHA",
")",
"and",
"the",
"phorbol",
"ester",
",",
"PMA",
",",
"activated",
"transcription",
"initiation",
"from",
"the",
"IL-3",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
972 | [
"To",
"define",
"the",
"regions",
"of",
"the",
"gene",
"required",
"for",
"transcription",
"activation",
",",
"we",
"generated",
"a",
"series",
"of",
"reporter",
"constructs",
"containing",
"different",
"regions",
"of",
"the",
"IL-3",
"gene",
"5",
"'",
"and",
"3",
"'",
"flanking",
"sequences",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0
] |
973 | [
"Both",
"positive",
"and",
"negative",
"regulatory",
"elements",
"were",
"identified",
"in",
"the",
"proximal",
"5",
"'",
"flanking",
"region",
"of",
"the",
"IL-3",
"gene",
"."
] | [
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
974 | [
"The",
"promoter",
"region",
"between",
"-173",
"and",
"-60",
"contained",
"the",
"strongest",
"activating",
"elements",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
975 | [
"The",
"transcription",
"factor",
"AP-1",
"could",
"bind",
"to",
"this",
"positive",
"activator",
"region",
"of",
"the",
"promoter",
"."
] | [
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
976 | [
"We",
"also",
"examined",
"the",
"function",
"of",
"the",
"IL-3",
"CK-1/CK-2",
"elements",
"that",
"are",
"present",
"in",
"many",
"cytokine",
"genes",
"and",
"found",
"that",
"they",
"acted",
"as",
"a",
"repressor",
"of",
"basal",
"level",
"expression",
"when",
"cloned",
"upstream",
"of",
"a",
"heterologous",
"promoter",
"but",
"were",
"also",
"inducible",
"by",
"PMA",
"/PHA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
977 | [
"Expression",
"of",
"the",
"Runt",
"domain-encoding",
"PEBP2",
"alpha",
"genes",
"in",
"T",
"cells",
"during",
"thymic",
"development",
"."
] | [
0,
0,
0,
9,
0,
1,
2,
2,
0,
7,
8,
0,
0,
0,
0
] |
978 | [
"The",
"PEBP2",
"alpha",
"A",
"and",
"PEBP2",
"alpha",
"B",
"genes",
"encode",
"the",
"DNA-binding",
"subunit",
"of",
"a",
"murine",
"transcription",
"factor",
",",
"PEBP2",
",",
"which",
"is",
"implicated",
"as",
"a",
"T-cell-specific",
"transcriptional",
"regulator",
"."
] | [
0,
1,
2,
2,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
979 | [
"These",
"two",
"related",
"genes",
"share",
"the",
"evolutionarily",
"conserved",
"region",
"encoding",
"the",
"Runt",
"domain",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
980 | [
"PEBP2",
"alpha",
"B",
"is",
"the",
"murine",
"counterpart",
"of",
"human",
"AML1",
",",
"which",
"is",
"located",
"at",
"the",
"breakpoints",
"of",
"the",
"8",
";",
"21",
"and",
"3",
";",
"21",
"chromosome",
"translocations",
"associated",
"with",
"acute",
"myeloid",
"leukemia",
"."
] | [
9,
10,
10,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
981 | [
"Northern",
"(",
"RNA",
")",
"blots",
"of",
"various",
"adult",
"mouse",
"tissues",
"revealed",
"that",
"the",
"levels",
"of",
"expression",
"of",
"both",
"genes",
"were",
"most",
"prominent",
"in",
"the",
"thymus",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
982 | [
"Furthermore",
",",
"transcripts",
"of",
"PEBP2",
"alpha",
"A",
"and",
"mouse",
"AML1/PEBP2",
"alpha",
"B",
"were",
"detected",
"in",
"T",
"lymphocytes",
"in",
"the",
"thymuses",
"from",
"day",
"16",
"embryos",
"and",
"newborns",
",",
"as",
"well",
"as",
"4-week-old",
"adult",
"mice",
",",
"by",
"in",
"situ",
"hybridization",
"."
] | [
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
10,
10,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
983 | [
"The",
"expression",
"of",
"the",
"genes",
"persisted",
"in",
"peripheral",
"lymph",
"nodes",
"of",
"adult",
"mice",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
984 | [
"The",
"transcripts",
"were",
"detected",
"in",
"all",
"the",
"CD4-",
"CD8-",
",",
"CD4+",
"CD8+",
",",
"CD4+",
"CD8-",
",",
"and",
"CD4-",
"CD8+",
"cell",
"populations",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
985 | [
"The",
"results",
"indicated",
"that",
"both",
"genes",
"are",
"expressed",
"in",
"T",
"cells",
"throughout",
"their",
"development",
",",
"supporting",
"the",
"notion",
"that",
"PEBP2",
"is",
"a",
"T-cell-specific",
"transcription",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
986 | [
"Transcripts",
"of",
"mouse",
"AML1/PEBP2",
"alpha",
"B",
"were",
"also",
"detected",
"in",
"day",
"12",
"fetal",
"hematopoietic",
"liver",
"and",
"in",
"the",
"bone",
"marrow",
"cells",
"of",
"newborn",
"mice",
"."
] | [
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0
] |
987 | [
"The",
"implication",
"of",
"mouse",
"AML1/PEBP2",
"alpha",
"B",
"expression",
"in",
"hematopoietic",
"cells",
"other",
"than",
"those",
"of",
"T-cell",
"lineage",
"is",
"discussed",
"in",
"relation",
"to",
"myeloid",
"leukemogenesis",
"."
] | [
0,
0,
0,
9,
10,
10,
10,
0,
0,
7,
8,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0
] |
988 | [
"Effects",
"of",
"glucocorticoids",
"on",
"transcription",
"factor",
"activation",
"in",
"human",
"peripheral",
"blood",
"mononuclear",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0
] |
989 | [
"Glucocorticoids",
"have",
"an",
"inhibitory",
"effect",
"on",
"inflammatory",
"and",
"immune",
"responses",
",",
"and",
"this",
"may",
"be",
"through",
"the",
"modulation",
"of",
"transcription",
"factor",
"binding",
"to",
"DNA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
990 | [
"The",
"interaction",
"of",
"the",
"transcription",
"factors",
",",
"activator",
"protein-1",
"(",
"AP-1",
")",
",",
"nuclear",
"factor",
"kappa",
"B",
"(",
"NF",
"kappa",
"B",
")",
",",
"and",
"cAMP-responsive",
"element",
"binding",
"protein",
"(",
"CREB",
")",
"with",
"DNA",
"and",
"glucocorticoid",
"receptors",
"(",
"GR",
")",
"was",
"analyzed",
"in",
"human",
"peripheral",
"blood",
"mononuclear",
"cells",
"by",
"gel",
"mobility",
"shift",
"assays",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
9,
10,
10,
10,
0,
9,
10,
10,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0
] |
991 | [
"TNF-alpha",
",",
"IL-1",
"beta",
"and",
"phorbol",
"myristate",
"acetate",
"(",
"PMA",
")",
"treatment",
"increased",
"AP-1",
"and",
"NF",
"kappa",
"B",
"DNA",
"binding",
"by",
"up",
"to",
"200",
"%",
"but",
"decreased",
"CREB",
"binding",
"(",
"38",
"%",
")",
"over",
"a",
"60-min",
"time",
"course",
"."
] | [
9,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
992 | [
"Dexamethasone",
"produced",
"a",
"rapid",
"and",
"sustained",
"increase",
"in",
"glucocorticoid",
"response",
"element",
"binding",
"and",
"a",
"concomitant",
"40-50",
"%",
"decrease",
"in",
"AP-1",
",",
"NF",
"kappa",
"B",
",",
"and",
"CREB",
"DNA",
"binding",
"that",
"was",
"blocked",
"by",
"combined",
"dexamethasone",
"and",
"cytokine",
"or",
"PMA",
"treatment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
10,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
993 | [
"These",
"latter",
"effects",
"were",
"due",
"to",
"increases",
"in",
"the",
"nuclear",
"localization",
"of",
"GR",
",",
"not",
"to",
"reduced",
"amounts",
"of",
"the",
"other",
"transcription",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
994 | [
"This",
"suggests",
"that",
"in",
"these",
"cells",
"GR",
"within",
"the",
"nucleus",
"interacts",
"with",
"cytokine-stimulated",
"transcription",
"factors",
"by",
"the",
"process",
"of",
"cross",
"coupling",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
995 | [
"This",
"may",
"be",
"an",
"important",
"molecular",
"site",
"of",
"steroid",
"action",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
996 | [
"Differential",
"induction",
"of",
"the",
"NF-AT",
"complex",
"during",
"restimulation",
"and",
"the",
"induction",
"of",
"T-cell",
"anergy",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
997 | [
"Stimulation",
"of",
"human",
"CD4+",
"T-cell",
"clones",
"through",
"the",
"T-cell",
"receptor",
"(",
"TcR",
")",
"by",
"high",
"doses",
"of",
"specific",
"peptide",
"results",
"in",
"the",
"induction",
"of",
"a",
"long-lived",
"state",
"of",
"nonresponsiveness",
"that",
"has",
"been",
"called",
"anergy",
"."
] | [
0,
0,
5,
6,
6,
6,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
998 | [
"During",
"the",
"induction",
"of",
"anergy",
",",
"T",
"cells",
"are",
"phenotypically",
"similar",
"to",
"cells",
"responding",
"to",
"an",
"immunogenic",
"stimulus",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
999 | [
"The",
"amount",
"of",
"TcR",
"at",
"the",
"cell",
"surface",
"is",
"downmodulated",
",",
"whereas",
"the",
"CD2",
"and",
"CD25",
"receptors",
"are",
"increased",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
10,
0,
0,
0
] |
1000 | [
"When",
"restimulated",
",",
"however",
",",
"anergic",
"T",
"cells",
"fail",
"to",
"up-regulate",
"transcription",
"of",
"the",
"IL-2",
"gene",
"and",
"in",
"consequence",
"do",
"not",
"produce",
"IL-2",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
9,
0
] |