data/dev.conll

= PUNCT B-O
Manual PROPN B-LF
Ability PROPN I-LF
Classification PROPN I-LF
System PROPN I-LF
; PUNCT B-O
QUEST PROPN B-AC
= PUNCT B-O
Quest PROPN B-LF
- ADJ I-LF
Quality PROPN I-LF
of ADP I-LF
upper ADJ I-LF
extremity NOUN I-LF
skills NOUN I-LF
test NOUN I-LF
; PUNCT B-O
Cont PROPN B-O
= PUNCT B-O
control NOUN B-O
; PUNCT B-O
M NOUN B-O
= PUNCT B-O
male NOUN B-O
, PUNCT B-O
F NOUN B-O
= PUNCT B-O
female ADJ B-O
, PUNCT B-O
V NOUN B-O
= PUNCT B-O
verbal ADJ B-O
, PUNCT B-O
nonV NOUN B-O
= PUNCT B-O
non ADJ B-O
- ADJ B-O
Verbal ADJ B-O
, PUNCT B-O
|Quad NOUN B-O
= PUNCT B-O
quadriplegia NOUN B-O
, PUNCT B-O
Di NOUN B-O
= PUNCT B-O
Diplegia NOUN B-O
, PUNCT B-O
Hemi NOUN B-O
= PUNCT B-O
hemiplegia NOUN B-O
. PUNCT B-O

Electro NOUN B-LF
- PUNCT I-LF
oculography NOUN I-LF
( PUNCT B-O
EOG PROPN B-AC
) PUNCT B-O
( PUNCT B-O
RetiPort32 PROPN B-O
, PUNCT B-O
Roland PROPN B-O
Consult PROPN B-O
, PUNCT B-O
Wiesbaden PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
was AUX B-O
performed VERB B-O
in ADP B-O
all DET B-O
patients NOUN B-O
according VERB B-O
to ADP B-O
the DET B-O
guidelines NOUN B-O
of ADP B-O
the DET B-O
International PROPN B-O
Society PROPN B-O
for ADP B-O
Clinical PROPN B-O
Electrophysiology PROPN B-O
of ADP B-O
Vision PROPN B-O
( PUNCT B-O
ISCEV).[12 PROPN B-O
] PUNCT B-O
Arden NOUN B-O
ratios NOUN B-O
below ADP B-O
1.8 NUM B-O
were AUX B-O
rated VERB B-O
as ADP B-O
pathologic ADJ B-O
. PUNCT B-O

Soluble ADJ B-LF
N NOUN I-LF
- NOUN I-LF
ethylmaleimide NOUN I-LF
- NOUN I-LF
sensitive ADJ I-LF
factor NOUN I-LF
attachment NOUN I-LF
protein NOUN I-LF
receptor NOUN I-LF
( PUNCT B-O
SNARE PROPN B-AC
) PUNCT B-O
proteins NOUN B-O
, PUNCT B-O
including VERB B-O
target- NOUN B-O
( PUNCT B-O
t- NOUN B-O
) PUNCT B-O
membrane NOUN B-O
SNAREs PROPN B-AC
( PUNCT B-O
Syntaxins PROPN B-LF
[ X B-O
Syn PROPN B-AC
] PUNCT B-O
) PUNCT B-O
and CCONJ B-O
synaptosomal NOUN B-O
- NOUN B-O
associated VERB B-O
proteins NOUN B-O
of ADP B-O
25 NUM B-O
kDa NOUN B-O
( PUNCT B-O
SNAP25 PROPN B-O
) PUNCT B-O
and CCONJ B-O
vesicle NOUN B-LF
- NOUN I-LF
associated VERB I-LF
membrane NOUN I-LF
proteins NOUN I-LF
( PUNCT B-O
VAMPs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
are AUX B-O
the DET B-O
fundamental ADJ B-O
components NOUN B-O
of ADP B-O
the DET B-O
exocytotic ADJ B-O
machinery NOUN B-O
required VERB B-O
for ADP B-O
the DET B-O
docking NOUN B-O
and CCONJ B-O
fusion NOUN B-O
of ADP B-O
secretory ADJ B-O
granules NOUN B-O
( PUNCT B-O
SGs PROPN B-AC
) PUNCT B-O
with ADP B-O
the DET B-O
plasma NOUN B-LF
membrane NOUN I-LF
( PUNCT B-O
PM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
have AUX B-O
been AUX B-O
well ADV B-O
studied VERB B-O
in ADP B-O
neurons NOUN B-O
[ X B-O
1 NUM B-O
, PUNCT B-O
2 NUM B-O
] PUNCT B-O
and CCONJ B-O
neuroendocrine ADJ B-O
cells NOUN B-O
, PUNCT B-O
particularly ADV B-O
pancreatic ADJ B-O
islet NOUN B-O
β PUNCT B-O
- NOUN B-O
cells NOUN B-O
[ X B-O
3–5 NUM B-O
] PUNCT B-O
. PUNCT B-O

t PROPN B-AC
-SNAREs PROPN B-AC
Syn-1A PROPN B-AC
and CCONJ B-O
SNAP25 PROPN B-O
through ADP B-O
their PRON B-O
interactions NOUN B-O
with ADP B-O
PM PROPN B-AC
- NOUN B-O
bound VERB B-O
voltage NOUN B-LF
- NOUN I-LF
gated VERB I-LF
calcium NOUN I-LF
channels NOUN I-LF
( PUNCT B-O
Cav PROPN B-AC
) PUNCT B-O
, PUNCT B-O
L NOUN B-O
- NOUN B-O
type NOUN B-O
in ADP B-O
β PUNCT B-O
- NOUN B-O
cells NOUN B-O
and CCONJ B-O
N NOUN B-O
- NOUN B-O
type NOUN B-O
in ADP B-O
neurons NOUN B-O
, PUNCT B-O
position VERB B-O
the DET B-O
predocked VERB B-O
SGs PROPN B-AC
to ADP B-O
the DET B-O
site NOUN B-O
of ADP B-O
maximum ADJ B-O
Ca2 NOUN B-O
+ NOUN B-O
influx NOUN B-O
for ADP B-O
efficient ADJ B-O
exocytosis NOUN B-O
[ X B-O
6–12 NUM B-O
] PUNCT B-O
. PUNCT B-O

Large ADJ B-O
whole ADJ B-LF
genome NOUN I-LF
sequencing NOUN I-LF
( PUNCT B-O
WGS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
whole ADJ B-LF
exome NOUN I-LF
sequencing NOUN I-LF
( PUNCT B-O
WES PROPN B-AC
) PUNCT B-O
studies NOUN B-O
in ADP B-O
IBD PROPN B-AC
are AUX B-O
in ADP B-O
progress NOUN B-O
. PUNCT B-O

Welsh PROPN B-O
and CCONJ B-O
coworkers NOUN B-O
first ADV B-O
reported VERB B-O
that SCONJ B-O
neurons NOUN B-O
within ADP B-O
the DET B-O
suprachiasmatic ADJ B-LF
nucleus NOUN I-LF
( PUNCT B-O
SCN PROPN B-AC
; PUNCT B-O
the DET B-O
master NOUN B-O
pacemaker NOUN B-O
in ADP B-O
the DET B-O
hypothalamus NOUN B-O
of ADP B-O
mammals NOUN B-O
) PUNCT B-O
are AUX B-O
surprisingly ADV B-O
heterogeneous ADJ B-O
in ADP B-O
their PRON B-O
intrinsic ADJ B-O
periods NOUN B-O
of ADP B-O
circadian ADJ B-O
firing NOUN B-O
pattern NOUN B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

So ADV B-O
far ADV B-O
, PUNCT B-O
reviews NOUN B-O
investigating VERB B-O
insulin NOUN B-O
pump NOUN B-O
therapy NOUN B-O
showed VERB B-O
mixed ADJ B-O
results NOUN B-O
regarding VERB B-O
the DET B-O
health NOUN B-LF
- PUNCT I-LF
related VERB I-LF
quality NOUN I-LF
of ADP I-LF
life NOUN I-LF
( PUNCT B-O
HRQOL PROPN B-AC
) PUNCT B-O
in ADP B-O
paediatric ADJ B-O
diabetes NOUN B-O
patients.[13 NOUN B-O
, PUNCT B-O
16 NUM B-O
, PUNCT B-O
17 NUM B-O
] PUNCT B-O
According VERB B-O
to ADP B-O
recent ADJ B-O
publications,[15 NOUN B-O
, PUNCT B-O
18–20 NUM B-O
] PUNCT B-O
there PRON B-O
is VERB B-O
still ADV B-O
a DET B-O
lack NOUN B-O
of ADP B-O
adequately ADV B-O
powered VERB B-O
studies NOUN B-O
to ADP B-O
underpin VERB B-O
the DET B-O
advantages NOUN B-O
of ADP B-O
CSII PROPN B-AC
regarding VERB B-O
QoL PROPN B-AC
improvement NOUN B-O
for ADP B-O
children NOUN B-O
diagnosed VERB B-O
with ADP B-O
DM PROPN B-AC
and CCONJ B-O
to ADP B-O
potentially ADV B-O
balance VERB B-O
the DET B-O
higher ADJ B-O
treatment NOUN B-O
cost NOUN B-O
attached VERB B-O
to ADP B-O
it.[8 PRON B-O
] PUNCT B-O
Thus ADV B-O
, PUNCT B-O
insulin NOUN B-O
pumps NOUN B-O
are AUX B-O
– PUNCT B-O
forty NUM B-O
years NOUN B-O
after SCONJ B-O
they PRON B-O
were AUX B-O
first ADJ B-O
introduced VERB B-O
to ADP B-O
the DET B-O
market NOUN B-O
– PUNCT B-O
still ADV B-O
not PART B-O
part NOUN B-O
of ADP B-O
first ADJ B-O
- PUNCT B-O
line NOUN B-O
recommendations NOUN B-O
in ADP B-O
most ADJ B-O
countries NOUN B-O
around ADP B-O
the DET B-O
world NOUN B-O
. PUNCT B-O

The DET B-O
data NOUN B-O
are AUX B-O
reported VERB B-O
as ADP B-O
mean NOUN B-O
± SYM B-O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT B-O
SD PROPN B-AC
) PUNCT B-O
( PUNCT B-O
n NOUN B-O
≥ PUNCT B-O
3 NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
lack NOUN B-O
of ADP B-O
dystrophin NOUN B-O
in ADP B-O
Duchenne PROPN B-LF
muscular ADJ I-LF
dystrophy NOUN I-LF
( PUNCT B-O
DMD PROPN B-AC
) PUNCT B-O
compromises VERB B-O
the DET B-O
integrity NOUN B-O
and CCONJ B-O
function NOUN B-O
of ADP B-O
muscle NOUN B-O
fibers NOUN B-O
. PUNCT B-O

The DET B-O
respondents NOUN B-O
consisted VERB B-O
of ADP B-O
20 NUM B-O
to PART B-O
42 NUM B-O
years NOUN B-O
of ADP B-O
age NOUN B-O
with ADP B-O
a DET B-O
mean ADJ B-O
age NOUN B-O
and CCONJ B-O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT B-O
SD PROPN B-AC
) PUNCT B-O
of ADP B-O
25.95±3.81 NUM B-O
. PUNCT B-O

Here ADV B-O
we PRON B-O
provide VERB B-O
a DET B-O
direct ADJ B-O
demonstration NOUN B-O
, PUNCT B-O
based VERB B-O
on ADP B-O
our PRON B-O
analysis NOUN B-O
of ADP B-O
rad-50 NOUN B-O
mutants NOUN B-O
, PUNCT B-O
that SCONJ B-O
the DET B-O
meiotic ADJ B-O
program NOUN B-O
in ADP B-O
Caenorhabditis PROPN B-O
elegans NOUN B-O
involves VERB B-O
both DET B-O
acquisition NOUN B-O
and CCONJ B-O
loss NOUN B-O
of ADP B-O
a DET B-O
specialized ADJ B-O
mode NOUN B-O
of ADP B-O
double ADJ B-LF
- PUNCT I-LF
strand NOUN I-LF
break NOUN I-LF
repair NOUN I-LF
( PUNCT B-O
DSBR PROPN B-AC
) PUNCT B-O
. PUNCT B-O

In ADP B-O
premeiotic ADJ B-O
germ NOUN B-O
cells NOUN B-O
, PUNCT B-O
RAD-50 PROPN B-O
is AUX B-O
not PART B-O
required VERB B-O
to PART B-O
load VERB B-O
strand NOUN B-O
- PUNCT B-O
exchange NOUN B-O
protein NOUN B-O
RAD-51 PROPN B-O
at ADP B-O
sites NOUN B-O
of ADP B-O
spontaneous ADJ B-O
or CCONJ B-O
ionizing ADJ B-LF
radiation NOUN I-LF
( PUNCT B-O
IR)-inducedDSBs PROPN B-AC
. PUNCT B-O

A DET B-O
specialized ADJ B-O
meiotic ADJ B-O
DSBR PROPN B-AC
mode NOUN B-O
is AUX B-O
engaged VERB B-O
at ADP B-O
the DET B-O
onset NOUN B-O
of ADP B-O
meiotic ADJ B-O
prophase NOUN B-O
, PUNCT B-O
coincident ADJ B-O
with ADP B-O
assembly NOUN B-O
of ADP B-O
meiotic ADJ B-O
chromosome NOUN B-O
axis NOUN B-O
structures NOUN B-O
. PUNCT B-O

Figure NOUN B-O
3 NUM B-O
illustrates VERB B-O
the DET B-O
differences NOUN B-O
in ADP B-O
the DET B-O
estimates NOUN B-O
of ADP B-O
the DET B-O
annual ADJ B-LF
rate NOUN I-LF
of ADP I-LF
reduction NOUN I-LF
( PUNCT B-O
ARR PROPN B-AC
) PUNCT B-O
from ADP B-O
1990 NUM B-O
to ADP B-O
2010 NUM B-O
for ADP B-O
all DET B-O
countries NOUN B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
further ADV B-O
confirm VERB B-O
that SCONJ B-O
the DET B-O
interaction NOUN B-O
of ADP B-O
the DET B-O
η8 NUM B-O
helix NOUN B-O
with ADP B-O
Rps14 NOUN B-O
is AUX B-O
not PART B-O
an DET B-O
artifact NOUN B-O
of ADP B-O
crystal NOUN B-O
packing NOUN B-O
, PUNCT B-O
we PRON B-O
have AUX B-O
conducted VERB B-O
structural ADJ B-O
studies NOUN B-O
in ADP B-O
solution NOUN B-O
by ADP B-O
small ADJ B-LF
angle NOUN I-LF
X NOUN I-LF
- NOUN I-LF
ray NOUN I-LF
scattering NOUN I-LF
( PUNCT B-O
SAXS PROPN B-AC
) PUNCT B-O
on ADP B-O
the DET B-O
aFap7 NOUN B-O
– PUNCT B-O
aRps14 NOUN B-O
complex NOUN B-O
. PUNCT B-O

To PART B-O
identify VERB B-O
the DET B-O
BDNF PROPN B-AC
- PUNCT B-O
responsive ADJ B-O
proliferating VERB B-O
cells NOUN B-O
, PUNCT B-O
we PRON B-O
performed VERB B-O
co NOUN B-O
- PUNCT B-O
staining NOUN B-O
with ADP B-O
astrocyte NOUN B-O
marker NOUN B-O
GFAP PROPN B-O
and CCONJ B-O
found VERB B-O
that SCONJ B-O
the DET B-O
cells NOUN B-O
positive ADJ B-O
for ADP B-O
Ki67 PROPN B-AC
( PUNCT B-O
antigen NOUN B-LF
identified VERB I-LF
by ADP I-LF
monoclonal ADJ I-LF
antibody NOUN I-LF
Ki-67 PROPN I-LF
, PUNCT B-O
a DET B-O
marker NOUN B-O
for ADP B-O
proliferating VERB B-O
cells NOUN B-O
) PUNCT B-O
are AUX B-O
GFAP PROPN B-O
negative ADJ B-O
, PUNCT B-O
suggesting VERB B-O
that SCONJ B-O
BDNF PROPN B-AC
- PUNCT B-O
responsive ADJ B-O
proliferating VERB B-O
cells NOUN B-O
are AUX B-O
not PART B-O
astrocytes NOUN B-O
( PUNCT B-O
S7 NUM B-O
Fig NOUN B-O
, PUNCT B-O
S10 NUM B-O
Fig NOUN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
particular ADJ B-O
, PUNCT B-O
experiencing VERB B-O
moderate ADJ B-O
/ SYM B-O
high ADJ B-O
levels NOUN B-O
of ADP B-O
perceived VERB B-O
stress NOUN B-O
was AUX B-O
associated VERB B-O
with ADP B-O
a DET B-O
1.61 ADJ B-O
- ADJ B-O
fold ADJ B-O
increase NOUN B-O
in ADP B-O
the DET B-O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT B-O
OR PROPN B-AC
) PUNCT B-O
of ADP B-O
having AUX B-O
ever ADV B-O
smoked VERB B-O
( PUNCT B-O
95%CI PROPN B-AC
1.42 NUM B-O
, PUNCT B-O
1.83 NUM B-O
; PUNCT B-O
P<0.001 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
a DET B-O
1.67 ADJ B-O
- ADJ B-O
fold ADJ B-O
increase NOUN B-O
in ADP B-O
having AUX B-O
been AUX B-O
diagnosed VERB B-O
or CCONJ B-O
treated VERB B-O
for ADP B-O
hypertension NOUN B-O
( PUNCT B-O
95%CI PROPN B-AC
1.46 NUM B-O
, PUNCT B-O
1.90 NUM B-O
; PUNCT B-O
P<0.001 NUM B-O
) PUNCT B-O
. PUNCT B-O

Kaposi PROPN B-LF
's PART I-LF
sarcoma NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
herpesvirus NOUN I-LF
( PUNCT B-O
KSHV PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
most ADV B-O
recently ADV B-O
discovered VERB B-O
human ADJ B-O
herpesvirus NOUN B-O
and CCONJ B-O
the DET B-O
etiologic ADJ B-O
agent NOUN B-O
of ADP B-O
several ADJ B-O
neoplasms NOUN B-O
, PUNCT B-O
the DET B-O
most ADV B-O
prominent ADJ B-O
of ADP B-O
which PRON B-O
is AUX B-O
Kaposi PROPN B-O
's PART B-O
sarcoma NOUN B-O
( PUNCT B-O
KS PROPN B-O
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Other ADJ B-O
methods NOUN B-O
of ADP B-O
assaying VERB B-O
recombination NOUN B-O
in ADP B-O
A. NOUN B-O
thaliana PROPN B-O
have AUX B-O
been AUX B-O
developed VERB B-O
, PUNCT B-O
and CCONJ B-O
one NUM B-O
in ADP B-O
particular ADJ B-O
involving VERB B-O
a DET B-O
tandem NOUN B-O
disrupted VERB B-O
beta NOUN B-LF
- PUNCT I-LF
D NOUN I-LF
- PUNCT I-LF
glucuronidase NOUN I-LF
( PUNCT B-O
GUS PROPN B-AC
) PUNCT B-O
gene NOUN B-O
[ X B-O
43 X B-O
] PUNCT B-O
was AUX B-O
recently ADV B-O
applied VERB B-O
to PART B-O
study VERB B-O
recombination NOUN B-O
in ADP B-O
Atmus81 PROPN B-O
mutants NOUN B-O
[ X B-O
27 NUM B-O
] PUNCT B-O
. PUNCT B-O

Although SCONJ B-O
one PRON B-O
should AUX B-O
be AUX B-O
careful ADJ B-O
to ADP B-O
relate VERB B-O
absolute ADJ B-O
concentrations NOUN B-O
from ADP B-O
an DET B-O
in ADP B-O
vitro X B-O
assay NOUN B-O
to ADP B-O
actual ADJ B-O
drug NOUN B-O
concentrations NOUN B-O
administered VERB B-O
to ADP B-O
patients NOUN B-O
and CCONJ B-O
clinical ADJ B-O
antibiotic ADJ B-O
breakpoints NOUN B-O
[ PUNCT B-O
61 NUM B-O
] PUNCT B-O
, PUNCT B-O
we PRON B-O
found VERB B-O
that SCONJ B-O
the DET B-O
dose NOUN B-O
- PUNCT B-O
responses NOUN B-O
of ADP B-O
our PRON B-O
PAO1 PROPN B-O
WT PROPN B-AC
strain NOUN B-O
( PUNCT B-O
and CCONJ B-O
the DET B-O
resulting VERB B-O
minimal ADJ B-LF
inhibitory ADJ I-LF
concentrations NOUN I-LF
[ PUNCT B-O
MICs PROPN B-AC
] PUNCT B-O
, PUNCT B-O
Fig NUM B-O
1 NUM B-O
) PUNCT B-O
are AUX B-O
close ADJ B-O
to ADP B-O
the DET B-O
average ADJ B-O
MIC PROPN B-AC
values NOUN B-O
( PUNCT B-O
MIC50 NUM B-O
) PUNCT B-O
reported VERB B-O
in ADP B-O
a DET B-O
study NOUN B-O
across ADP B-O
7,452 NUM B-O
clinical ADJ B-O
P. PROPN B-O
aeruginosa PROPN B-O
isolates NOUN B-O
[ PUNCT B-O
62 NUM B-O
] PUNCT B-O
. PUNCT B-O

A DET B-O
15 NUM B-O
- PUNCT B-O
s NOUN B-O
rest NOUN B-O
period NOUN B-O
preceded VERB B-O
and CCONJ B-O
followed VERB B-O
each DET B-O
block NOUN B-O
. PUNCT B-O

( PUNCT B-O
C X B-O
) PUNCT B-O
Functional ADJ B-O
axial ADJ B-O
slices NOUN B-O
( PUNCT B-O
displayed VERB B-O
here ADV B-O
over ADP B-O
the DET B-O
anatomical ADJ B-O
image NOUN B-O
of ADP B-O
a DET B-O
representative ADJ B-O
subject NOUN B-O
) PUNCT B-O
were AUX B-O
acquired VERB B-O
and CCONJ B-O
covered VERB B-O
both CCONJ B-O
brain NOUN B-O
and CCONJ B-O
cervical ADJ B-O
spinal ADJ B-O
cord NOUN B-O
up ADP B-O
to ADP B-O
the DET B-O
first ADJ B-LF
thoracic ADJ I-LF
( PUNCT B-O
T1 PROPN B-AC
) PUNCT B-O
segment NOUN B-O
, PUNCT B-O
and CCONJ B-O
they PRON B-O
were AUX B-O
placed VERB B-O
at ADP B-O
an DET B-O
angle NOUN B-O
that SCONJ B-O
was AUX B-O
perpendicular ADJ B-O
to ADP B-O
the DET B-O
C4 NOUN B-O
vertebral ADJ B-O
segment NOUN B-O
. PUNCT B-O

( PUNCT B-O
D NOUN B-O
) PUNCT B-O
Performance NOUN B-O
speeds NOUN B-O
( PUNCT B-O
i.e. X B-O
, PUNCT B-O
block NOUN B-O
duration NOUN B-O
) PUNCT B-O
averaged VERB B-O
across ADP B-O
all DET B-O
subjects NOUN B-O
show VERB B-O
that SCONJ B-O
the DET B-O
learning NOUN B-O
curves NOUN B-O
differed VERB B-O
between ADP B-O
the DET B-O
CS PROPN B-AC
( PUNCT B-O
red ADJ B-O
) PUNCT B-O
and CCONJ B-O
SS PROPN B-AC
( PUNCT B-O
blue ADJ B-O
) PUNCT B-O
conditions NOUN B-O
. PUNCT B-O

We PRON B-O
found VERB B-O
that SCONJ B-O
SOCS1 PROPN B-O
- PUNCT B-O
silenced VERB B-O
DCs PROPN B-AC
broadly ADV B-O
induced VERB B-O
enhanced ADJ B-O
envelope NOUN B-LF
HIV-1 PROPN B-AC
( PUNCT B-O
Env)-specific PROPN B-AC
CD8 NOUN B-O
+ NOUN B-O
cytotoxic ADJ B-O
T NOUN B-O
lymphocytes NOUN B-O
and CCONJ B-O
CD4 NOUN B-O
+ NOUN B-O
T NOUN B-O
helper NOUN B-O
cells NOUN B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
antibody NOUN B-O
responses NOUN B-O
, PUNCT B-O
in ADP B-O
mice NOUN B-O
. PUNCT B-O

This PRON B-O
is AUX B-O
potentially ADV B-O
attributed VERB B-O
to ADP B-O
decreased VERB B-O
T PROPN B-LF
cell NOUN I-LF
receptor NOUN I-LF
( PUNCT B-O
TCR PROPN B-AC
) PUNCT B-O
signaling NOUN B-O
strength NOUN B-O
due ADP B-O
to ADP B-O
inefficiency NOUN B-O
in ADP B-O
promiscuous ADJ B-O
expression NOUN B-O
of ADP B-O
self NOUN B-O
- PUNCT B-O
antigens NOUN B-O
or CCONJ B-O
presenting VERB B-O
a DET B-O
neo NOUN B-O
- PUNCT B-O
self NOUN B-O
- PUNCT B-O
antigen NOUN B-O
by ADP B-O
medullary ADJ B-O
TECs PROPN B-AC
, PUNCT B-O
displaying VERB B-O
decreased VERB B-O
negative ADJ B-O
selection NOUN B-O
- PUNCT B-O
related VERB B-O
marker NOUN B-O
genes NOUN B-O
( PUNCT B-O
Nur77 PROPN B-O
and CCONJ B-O
CD5high PROPN B-O
) PUNCT B-O
in ADP B-O
CD4 PROPN B-O
single ADJ B-LF
positive ADJ I-LF
( PUNCT B-O
SP PROPN B-AC
) PUNCT B-O
thymocytes NOUN B-O
. PUNCT B-O

Members NOUN B-O
of ADP B-O
the DET B-O
plant NOUN B-O
Heme PROPN B-LF
Activator PROPN I-LF
Protein PROPN I-LF
( PUNCT B-O
HAP PROPN B-AC
) PUNCT B-O
or CCONJ B-O
NUCLEAR PROPN B-O
FACTOR PROPN B-O
Y PROPN B-O
( PUNCT B-O
NF PROPN B-O
- PUNCT B-O
Y PROPN B-O
) PUNCT B-O
are AUX B-O
trimeric ADJ B-O
transcription NOUN B-O
factor NOUN B-O
complexes NOUN B-O
composed VERB B-O
of ADP B-O
the DET B-O
NF PROPN B-O
- PUNCT B-O
YA PROPN B-O
, PUNCT B-O
NF PROPN B-O
- PUNCT B-O
YB PROPN B-O
and CCONJ B-O
NF PROPN B-O
- PUNCT B-O
YC PROPN B-O
subfamilies NOUN B-O
. PUNCT B-O

The DET B-O
wing NOUN B-O
cuticle NOUN B-O
is AUX B-O
a DET B-O
multilayered ADJ B-O
structure NOUN B-O
, PUNCT B-O
and CCONJ B-O
its PRON B-O
formation NOUN B-O
requires VERB B-O
the DET B-O
proper ADJ B-O
expression NOUN B-O
of ADP B-O
cuticle NOUN B-O
- PUNCT B-O
related VERB B-O
genes NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
enzymes NOUN B-O
involved VERB B-O
in ADP B-O
cuticle NOUN B-O
deposition NOUN B-O
, PUNCT B-O
and CCONJ B-O
zona NOUN B-LF
pellucida NOUN I-LF
( PUNCT B-O
ZP PROPN B-AC
) PUNCT B-O
domain NOUN B-O
proteins NOUN B-O
, PUNCT B-O
which PRON B-O
link VERB B-O
the DET B-O
apical ADJ B-O
surface NOUN B-O
of ADP B-O
wing NOUN B-O
cells NOUN B-O
to ADP B-O
the DET B-O
overlying VERB B-O
cuticle NOUN B-O
[ PUNCT B-O
37 NUM B-O
] PUNCT B-O
. PUNCT B-O

After ADP B-O
confirming VERB B-O
this DET B-O
result NOUN B-O
by ADP B-O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
reverse ADJ I-LF
transcription NOUN I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT B-O
qRT-PCR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
we PRON B-O
extended VERB B-O
the DET B-O
qRT PROPN B-AC
analysis NOUN B-O
to ADP B-O
other ADJ B-O
kidney NOUN B-O
diseases NOUN B-O
and CCONJ B-O
found VERB B-O
that SCONJ B-O
-PCRIFI27 PROPN B-AC
mRNA NOUN B-O
levels NOUN B-O
were AUX B-O
reduced VERB B-O
in ADP B-O
PBMCs PROPN B-AC
of ADP B-O
many ADJ B-O
patients NOUN B-O
. PUNCT B-O

a X B-O
) PUNCT B-O
correlation NOUN B-LF
coefficient NOUN B-O
r PROPN B-AC
, PUNCT B-O
which PRON B-O
ranges VERB B-O
between ADP B-O
0 NUM B-O
( PUNCT B-O
no DET B-O
relationship NOUN B-O
) PUNCT B-O
to ADP B-O
1 NUM B-O
( PUNCT B-O
perfect ADJ B-O
relationship NOUN B-O
) PUNCT B-O
or CCONJ B-O
-1 NUM B-O
( PUNCT B-O
perfect ADJ B-O
negative ADJ B-O
relationship NOUN B-O
) PUNCT B-O
respectively ADV B-O
. PUNCT B-O

Therefore ADV B-O
, PUNCT B-O
the DET B-O
aim NOUN B-O
of ADP B-O
this DET B-O
study NOUN B-O
was AUX B-O
to ADP B-O
evaluate VERB B-O
the DET B-O
importance NOUN B-O
of ADP B-O
both CCONJ B-O
systemic ADJ B-O
oxygen NOUN B-O
delivery NOUN B-O
factors NOUN B-O
and CCONJ B-O
peripheral ADJ B-O
factors NOUN B-O
for ADP B-O
aerobic ADJ B-O
ExCap PROPN B-AC
in ADP B-O
mild ADJ B-O
- ADJ B-O
to ADP B-O
- ADJ B-O
severe ADJ B-O
non ADJ B-O
- ADJ B-O
dialysis ADJ B-O
CKD PROPN B-AC
. PUNCT B-O

Handgrip NOUN B-O
strength NOUN B-O
, PUNCT B-O
lean ADJ B-LF
body NOUN I-LF
mass NOUN I-LF
( PUNCT B-O
LBM PROPN B-AC
) PUNCT B-O
and CCONJ B-O
vascular ADJ B-O
stiffness NOUN B-O
represent VERB B-O
peripheral ADJ B-O
factors NOUN B-O
in ADP B-O
the DET B-O
present ADJ B-O
study NOUN B-O
. PUNCT B-O

To PART B-O
further ADV B-O
investigate VERB B-O
whether SCONJ B-O
BMAL1 PROPN B-O
- PUNCT B-O
K537 PROPN B-O
acetylation NOUN B-O
up ADV B-O
- PUNCT B-O
regulates VERB B-O
BMAL1 PROPN B-O
– PUNCT B-O
CK2β NOUN B-O
binding VERB B-O
and CCONJ B-O
subsequently ADV B-O
represses VERB B-O
BMAL1 PROPN B-O
- PUNCT B-O
S90 NOUN B-O
phosphorylation NOUN B-O
, PUNCT B-O
we PRON B-O
utilized VERB B-O
a DET B-O
mouse NOUN B-O
fibroblast NOUN B-O
cell NOUN B-O
line NOUN B-O
deficient ADJ B-O
in ADP B-O
silent ADJ B-O
information NOUN B-O
regulator NOUN B-O
1 NUM B-O
( PUNCT B-O
SIRT1 PROPN B-O
) PUNCT B-O
, PUNCT B-O
a DET B-O
member NOUN B-O
of ADP B-O
the DET B-O
sirtuin NOUN B-O
family NOUN B-O
of ADP B-O
NAD+-dependent PROPN B-O
histone NOUN B-LF
deacetylases NOUN I-LF
( PUNCT B-O
HDACs PROPN B-AC
) PUNCT B-O
that PRON B-O
also ADV B-O
targets VERB B-O
acetyl NOUN B-O
BMAL1 PROPN B-O
- PUNCT B-O
K537 PROPN B-O
[ PUNCT B-O
30 NUM B-O
] PUNCT B-O
. PUNCT B-O

EP PROPN B-AC
: PUNCT B-O
Group NOUN B-O
: PUNCT B-O
extra ADJ B-LF
- ADJ I-LF
perigastric ADJ I-LF
lymph NOUN B-O
node NOUN B-O
group NOUN B-O
A DET B-O
recent ADJ B-O
result NOUN B-O
from ADP B-O
S. PROPN B-O
pombe PROPN B-O
suggests VERB B-O
that SCONJ B-O
in ADP B-O
this DET B-O
organism NOUN B-O
, PUNCT B-O
in ADP B-O
which PRON B-O
all DET B-O
COs PROPN B-AC
are AUX B-O
mediated VERB B-O
by ADP B-O
Mus81 PROPN B-O
- PUNCT B-O
Eme1 PROPN B-O
, PUNCT B-O
the DET B-O
predominant ADJ B-O
meiotic ADJ B-O
recombination NOUN B-O
intermediate NOUN B-O
is AUX B-O
a DET B-O
single ADJ B-LF
Holliday PROPN I-LF
junction NOUN I-LF
( PUNCT B-O
sHJ PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
26 NUM B-O
] PUNCT B-O
. PUNCT B-O

Ab PROPN B-AC
, PUNCT B-O
antibody NOUN B-LF
; PUNCT B-O
EC50 PROPN B-AC
, PUNCT B-O
half ADJ B-LF
- PUNCT I-LF
maximal ADJ I-LF
effective ADJ I-LF
concentration NOUN I-LF
; PUNCT B-O
IL-6R PROPN B-AC
, PUNCT B-O
interleukin-6 NOUN B-LF
receptor NOUN I-LF
; PUNCT B-O
MMP PROPN B-AC
, PUNCT B-O
matrix NOUN B-LF
metalloproteinase NOUN I-LF
. PUNCT B-O

QALY PROPN B-AC
, PUNCT B-O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
year NOUN I-LF
; PUNCT B-O
USD PROPN B-O
, PUNCT B-O
US PROPN B-O
dollars NOUN B-O
. PUNCT B-O

We PRON B-O
adapted VERB B-O
the DET B-O
Preferred ADJ B-LF
Reporting PROPN I-LF
Items PROPN I-LF
for ADP I-LF
Systematic PROPN I-LF
Reviews PROPN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PUNCT I-LF
Analyses PROPN I-LF
( PUNCT B-O
PRISMA PROPN B-AC
) PUNCT B-O
statement NOUN B-O
for ADP B-O
scoping NOUN B-O
reviews NOUN B-O
to PART B-O
report VERB B-O
our PRON B-O
systematic ADJ B-O
review NOUN B-O
of ADP B-O
observational ADJ B-O
and CCONJ B-O
interventional ADJ B-O
studies NOUN B-O
[ X B-O
19 X B-O
] X B-O
( PUNCT B-O
S1 PROPN B-O
Table NOUN B-O
) PUNCT B-O
. PUNCT B-O

Plates NOUN B-O
were AUX B-O
developed VERB B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
optical ADJ B-LF
density NOUN I-LF
( PUNCT B-O
OD PROPN B-AC
) PUNCT B-O
was AUX B-O
read VERB B-O
using VERB B-O
a DET B-O
spectrophotometer NOUN B-O
( PUNCT B-O
microplate NOUN B-O
reader NOUN B-O
; PUNCT B-O
Molecular PROPN B-O
Devices PROPN B-O
, PUNCT B-O
Sunnyvale PROPN B-O
, PUNCT B-O
CA PROPN B-O
, PUNCT B-O
US PROPN B-O
) PUNCT B-O
. PUNCT B-O

Raw ADJ B-O
OD PROPN B-AC
for ADP B-O
each DET B-O
specimen NOUN B-O
was AUX B-O
normalized VERB B-O
using VERB B-O
the DET B-O
calibrator NOUN B-O
OD PROPN B-AC
on ADP B-O
each DET B-O
plate NOUN B-O
as ADP B-O
a DET B-O
ratio NOUN B-O
, PUNCT B-O
such ADJ B-O
that SCONJ B-O
normalized VERB B-O
OD PROPN B-AC
= SYM B-O
OD PROPN B-AC
of ADP B-O
specimen NOUN B-O
/ SYM B-O
median NOUN B-O
OD PROPN B-AC
of ADP B-O
calibrator NOUN B-O
. PUNCT B-O

Hemophagocytic ADJ B-LF
lymphohistiocytosis NOUN I-LF
( PUNCT B-O
HLH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
also ADV B-O
known VERB B-O
as ADP B-O
hemophagocytic ADJ B-O
syndrome NOUN B-O
, PUNCT B-O
is AUX B-O
a DET B-O
rare ADJ B-O
, PUNCT B-O
life NOUN B-O
threatening VERB B-O
hyperinflammatory ADJ B-O
syndrome NOUN B-O
characterized VERB B-O
by ADP B-O
excessive ADJ B-O
activation NOUN B-O
of ADP B-O
histiocytes NOUN B-O
and CCONJ B-O
T NOUN B-O
lymphocytes NOUN B-O
leading VERB B-O
to ADP B-O
highly ADV B-O
active ADJ B-O
but CCONJ B-O
ineffective ADJ B-O
immune ADJ B-O
response NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Our PRON B-O
assumption NOUN B-O
of ADP B-O
constant ADJ B-O
As PROPN B-AC
levels NOUN B-O
throughout ADP B-O
the DET B-O
study NOUN B-O
period NOUN B-O
is AUX B-O
supported VERB B-O
by ADP B-O
geological ADJ B-O
data NOUN B-O
which PRON B-O
document VERB B-O
stable ADJ B-O
arsenic NOUN B-LF
contamination NOUN B-O
of ADP B-O
the DET B-O
hydrothermal ADJ B-O
system NOUN B-O
that DET B-O
has AUX B-O
supplied VERB B-O
drinking NOUN B-O
water NOUN B-O
in ADP B-O
the DET B-O
study NOUN B-O
area NOUN B-O
since SCONJ B-O
the DET B-O
‘ PUNCT B-O
70s NOUN B-O
[ PUNCT B-O
14 NUM B-O
, PUNCT B-O
15 NUM B-O
, PUNCT B-O
17–19 NUM B-O
] PUNCT B-O
and CCONJ B-O
to ADP B-O
the DET B-O
lack NOUN B-O
of ADP B-O
any DET B-O
remediation NOUN B-O
treatment NOUN B-O
in ADP B-O
that DET B-O
time NOUN B-O
due ADP B-O
to ADP B-O
the DET B-O
long ADJ B-O
period NOUN B-O
of ADP B-O
derogations NOUN B-O
[ PUNCT B-O
68 NUM B-O
] PUNCT B-O
. PUNCT B-O

NCD PROPN B-AC
, PUNCT B-O
noncommunicable ADJ B-LF
disease NOUN I-LF
; PUNCT B-O
OLS PROPN B-AC
, PUNCT B-O
ordinary ADJ B-LF
least ADJ I-LF
squares NOUN I-LF
. PUNCT B-O

To PART B-O
further ADV B-O
identify VERB B-O
the DET B-O
molecular ADJ B-O
mechanism NOUN B-O
of ADP B-O
sIBM PROPN B-AC
, PUNCT B-O
we PRON B-O
amplified VERB B-O
whole ADJ B-O
mitochondrial ADJ B-LF
DNA NOUN I-LF
( PUNCT B-O
mtDNA PROPN B-AC
) PUNCT B-O
from ADP B-O
myoblasts NOUN B-O
from ADP B-O
normal ADJ B-O
controls NOUN B-O
and CCONJ B-O
3 NUM B-O
sIBM PROPN B-AC
patients NOUN B-O
. PUNCT B-O

To PART B-O
test VERB B-O
whether SCONJ B-O
F NOUN B-O
- PUNCT B-O
actin NOUN B-O
polymerization NOUN B-O
dynamics NOUN B-O
are AUX B-O
required VERB B-O
for ADP B-O
proper ADJ B-O
VP26 PROPN B-O
organization NOUN B-O
, PUNCT B-O
we PRON B-O
treated VERB B-O
cells NOUN B-O
with ADP B-O
the DET B-O
actin NOUN B-O
filament NOUN B-O
- PUNCT B-O
stabilizing VERB B-O
drug NOUN B-O
jasplakinolide PROPN B-LF
( PUNCT B-O
jasp PROPN B-AC
) PUNCT B-O
. PUNCT B-O

There PRON B-O
were VERB B-O
no DET B-O
reported VERB B-O
differences NOUN B-O
between ADP B-O
deaths NOUN B-O
in ADP B-O
males NOUN B-O
and CCONJ B-O
females NOUN B-O
in ADP B-O
Boukoki PROPN B-O
( PUNCT B-O
male NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
female NOUN I-LF
ratio NOUN I-LF
[ PUNCT B-O
M:Fratio PROPN B-AC
] PUNCT B-O
1.3:1 NUM B-O
[ PUNCT B-O
17:13 NUM B-O
, PUNCT B-O
p NOUN B-O
= SYM B-O
0.79 NUM B-O
] PUNCT B-O
) PUNCT B-O
or CCONJ B-O
in ADP B-O
Moursal PROPN B-O
( PUNCT B-O
M PROPN B-AC
1.5:1 NUM B-O
[ PUNCT B-O
12:8 NUM B-O
, PUNCT B-O
p NOUN B-O
= SYM B-O
0.75 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Rev NOUN B-O
# NOUN B-O
3 NUM B-O
: PUNCT B-O
“ PUNCT B-O
Is AUX B-O
GAL PROPN B-AC
gene NOUN B-O
optimization NOUN B-O
not PART B-O
correlated VERB B-O
with ADP B-O
growth NOUN B-O
under ADP B-O
other ADJ B-O
( PUNCT B-O
non ADJ B-O
- ADJ B-O
galactose ADJ B-LF
) PUNCT B-O
growth NOUN B-O
conditions NOUN B-O
? PUNCT B-O
” PUNCT B-O
As SCONJ B-O
the DET B-O
world NOUN B-O
edges VERB B-O
closer ADV B-O
to ADP B-O
global ADJ B-O
polio NOUN B-O
eradication NOUN B-O
and CCONJ B-O
continues VERB B-O
the DET B-O
strategic ADJ B-O
withdrawal NOUN B-O
of ADP B-O
the DET B-O
Oral PROPN B-LF
Polio PROPN I-LF
Vaccine PROPN I-LF
( PUNCT B-O
OPV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
regular ADJ B-O
identification NOUN B-O
of ADP B-O
, PUNCT B-O
and CCONJ B-O
rapid ADJ B-O
response NOUN B-O
to ADP B-O
, PUNCT B-O
these DET B-O
silent ADJ B-O
chains NOUN B-O
of ADP B-O
transmission NOUN B-O
is AUX B-O
of ADP B-O
the DET B-O
utmost ADJ B-O
importance NOUN B-O
. PUNCT B-O

ABA PROPN B-AC
, PUNCT B-O
abscisic NOUN B-LF
acid NOUN I-LF
; PUNCT B-O
BR PROPN B-AC
, PUNCT B-O
brassinosteroid NOUN B-LF
; PUNCT B-O
GA3 PROPN B-AC
, PUNCT B-O
gibberellic NOUN B-LF
acid3 NOUN I-LF
; PUNCT B-O
ZR PROPN B-AC
, PUNCT B-O
zeatin NOUN B-LF
riboside NOUN I-LF
Green ADJ B-LF
tea NOUN I-LF
( PUNCT B-O
GT PROPN B-AC
) PUNCT B-O
catechins NOUN B-O
have VERB B-O
been AUX B-O
shown VERB B-O
to PART B-O
have VERB B-O
anti ADJ B-O
- ADJ B-O
obesity ADJ B-O
effects NOUN B-O
in ADP B-O
humans NOUN B-O
. PUNCT B-O

We PRON B-O
inserted VERB B-O
the DET B-O
CAN1 PROPN B-O
and CCONJ B-O
URA3 PROPN B-O
genes NOUN B-O
, PUNCT B-O
two NUM B-O
counter ADJ B-O
- PUNCT B-O
selectable ADJ B-O
markers NOUN B-O
, PUNCT B-O
∼10 NUM B-O
kb NOUN B-O
from ADP B-O
the DET B-O
telomere NOUN B-O
of ADP B-O
ChrXV PROPN B-O
- PUNCT B-O
L PROPN B-O
( PUNCT B-O
Figure PROPN B-O
1A NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
simultaneous ADJ B-O
loss NOUN B-O
of ADP B-O
CAN1 PROPN B-O
and CCONJ B-O
URA3 PROPN B-O
( PUNCT B-O
detected VERB B-O
on ADP B-O
media NOUN B-O
containing VERB B-O
canavinine NOUN B-LF
[ X B-O
can PROPN B-AC
] PUNCT B-O
and CCONJ B-O
5 NUM B-O
- PUNCT B-O
fluoro NOUN B-O
- PUNCT B-O
orotic ADJ B-O
acid NOUN B-O
[ X B-O
5 NUM B-O
- PUNCT B-O
FOA NOUN B-O
] PUNCT B-O
) PUNCT B-O
at ADP B-O
this DET B-O
locus NOUN B-O
occurs VERB B-O
at ADP B-O
a DET B-O
rate NOUN B-O
of ADP B-O
8.9 NUM B-O
× PUNCT B-O
10−8 NUM B-O
( PUNCT B-O
Table PROPN B-O
1 NUM B-O
) PUNCT B-O
, PUNCT B-O
approximately ADV B-O
250 NUM B-O
- PUNCT B-O
fold ADJ B-O
higher ADJ B-O
than ADP B-O
the DET B-O
rate NOUN B-O
observed VERB B-O
at ADP B-O
ChrV PROPN B-O
- PUNCT B-O
L PROPN B-O
( PUNCT B-O
3.5 NUM B-O
× PUNCT B-O
10−10 NUM B-O
; PUNCT B-O
Table PROPN B-O
2 NUM B-O
) PUNCT B-O
. PUNCT B-O

Pilot NOUN B-O
studies NOUN B-O
with ADP B-O
exhaustive ADJ B-O
sampling NOUN B-O
, PUNCT B-O
progressive ADJ B-O
means NOUN B-O
analysis NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
formula NOUN B-O
of ADP B-O
West PROPN B-O
et PROPN B-O
al PROPN B-O
. PUNCT B-O

, PUNCT B-O
[ PUNCT B-O
166 NUM B-O
] PUNCT B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
a PRON B-O
posteriori X B-O
power NOUN B-O
analysis NOUN B-O
, PUNCT B-O
using VERB B-O
data NOUN B-O
from ADP B-O
our PRON B-O
previous ADJ B-O
studies NOUN B-O
of ADP B-O
cell NOUN B-O
and CCONJ B-O
axon NOUN B-O
densities NOUN B-O
, PUNCT B-O
or CCONJ B-O
tract NOUN B-O
tracing NOUN B-O
of ADP B-O
pathways NOUN B-O
, PUNCT B-O
took VERB B-O
into ADP B-O
consideration NOUN B-O
all DET B-O
known VERB B-O
and CCONJ B-O
estimated VERB B-O
variables NOUN B-O
, PUNCT B-O
including VERB B-O
age NOUN B-O
, PUNCT B-O
sex NOUN B-O
, PUNCT B-O
postmortem ADJ B-LF
interval NOUN I-LF
( PUNCT B-O
PMI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
other ADJ B-O
diagnoses NOUN B-O
. PUNCT B-O

A DET B-O
series NOUN B-O
of ADP B-O
computer NOUN B-O
- PUNCT B-O
aided VERB B-O
virtual ADJ B-O
screening VERB B-O
techniques NOUN B-O
were AUX B-O
utilized VERB B-O
to PART B-O
identify VERB B-O
potential ADJ B-O
agonists NOUN B-O
of ADP B-O
STING PROPN B-AC
. PUNCT B-O

Structure NOUN B-O
- PUNCT B-O
based VERB B-O
screening VERB B-O
using VERB B-O
Libdock PROPN B-O
was AUX B-O
carried VERB B-O
out ADP B-O
followed VERB B-O
by ADP B-O
ADME PROPN B-AC
( PUNCT B-O
absorption NOUN B-LF
, PUNCT I-LF
distribution NOUN I-LF
, PUNCT I-LF
metabolism NOUN I-LF
, PUNCT I-LF
excretion NOUN I-LF
) PUNCT B-O
and CCONJ B-O
toxicity NOUN B-O
prediction NOUN B-O
. PUNCT B-O

Since SCONJ B-O
the DET B-O
absolute ADJ B-O
precision NOUN B-O
is AUX B-O
depending VERB B-O
on ADP B-O
prevalence NOUN B-O
of ADP B-O
atrial ADJ B-LF
fibrillation NOUN I-LF
, PUNCT B-O
which PRON B-O
was AUX B-O
low ADJ B-O
in ADP B-O
the DET B-O
screened VERB B-O
population NOUN B-O
, PUNCT B-O
one PRON B-O
must AUX B-O
consider VERB B-O
sample NOUN B-O
size NOUN B-O
, PUNCT B-O
i.e. X B-O
what PRON B-O
is AUX B-O
the DET B-O
absolute ADJ B-O
precision NOUN B-O
in ADP B-O
the DET B-O
validation NOUN B-O
trial NOUN B-O
with ADP B-O
the DET B-O
reported VERB B-O
sample NOUN B-O
size NOUN B-O
and CCONJ B-O
AF PROPN B-AC
prevalence NOUN B-O
? PUNCT B-O
We PRON B-O
also ADV B-O
described VERB B-O
the DET B-O
dilutions NOUN B-O
of ADP B-O
the DET B-O
antibody NOUN B-O
in ADP B-O
the DET B-O
“ PUNCT B-O
Results NOUN B-O
” PUNCT B-O
section NOUN B-O
under ADP B-O
the DET B-O
heading NOUN B-O
“ PUNCT B-O
Detection NOUN B-O
of ADP B-O
anti ADJ B-O
- PUNCT B-O
FXIII/13 PROPN B-AC
- PUNCT B-O
A NOUN B-O
autoantibodies NOUN B-O
using VERB B-O
enzyme NOUN B-LF
- PUNCT I-LF
linked VERB I-LF
immunosorbent ADJ I-LF
assay NOUN I-LF
( PUNCT B-O
ELISA PROPN B-AC
) PUNCT B-O
” PUNCT B-O
( PUNCT B-O
p.12 NOUN B-O
, PUNCT B-O
lane NOUN B-O
3 NUM B-O
) PUNCT B-O
. PUNCT B-O

They PRON B-O
invade VERB B-O
primary ADJ B-O
tumors NOUN B-O
, PUNCT B-O
where SCONJ B-O
they PRON B-O
promote VERB B-O
angiogenesis NOUN B-O
, PUNCT B-O
via ADP B-O
Matrix PROPN B-LF
Metaloproteinases PROPN I-LF
( PUNCT B-O
MMP PROPN B-AC
) PUNCT B-O
secretion NOUN B-O
and CCONJ B-O
Vascular PROPN B-LF
Endothelial PROPN I-LF
Growth PROPN I-LF
Factor PROPN I-LF
( PUNCT B-O
VEGF PROPN B-AC
) PUNCT B-O
production NOUN B-O
[ PUNCT B-O
24 NUM B-O
] PUNCT B-O
. PUNCT B-O

All DET B-O
AmpC NOUN B-LF
beta NOUN I-LF
AmpC PROPN B-AC
- PUNCT I-LF
lactamase NOUN I-LF
producing VERB B-O
GNB PROPN B-AC
were AUX B-O
detected VERB B-O
in ADP B-O
urine NOUN B-O
specimens NOUN B-O
3.3 NUM B-O
% PUNCT B-O
( PUNCT B-O
8/244 NUM B-O
) PUNCT B-O
and CCONJ B-O
in ADP B-O
patients NOUN B-O
whose DET B-O
age NOUN B-O
group NOUN B-O
was AUX B-O
above ADP B-O
61 NUM B-O
years NOUN B-O
( PUNCT B-O
40.1 NUM B-O
% PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Temperature NOUN B-O
data NOUN B-O
such ADJ B-O
as ADP B-O
the DET B-O
decadal ADJ B-O
( PUNCT B-O
10 NUM B-O
- PUNCT B-O
day NOUN B-O
) PUNCT B-O
mean ADJ B-O
daily ADJ B-O
maximum ADJ B-O
air NOUN B-O
temperature NOUN B-O
( PUNCT B-O
DMDMAT PROPN B-AC
) PUNCT B-O
were AUX B-O
obtained VERB B-O
from ADP B-O
a DET B-O
nearby ADJ B-O
weather NOUN B-O
station NOUN B-O
and CCONJ B-O
statistical ADJ B-O
correlations NOUN B-O
between ADP B-O
tick NOUN B-O
occurrence NOUN B-O
and CCONJ B-O
minimal ADJ B-LF
infection NOUN I-LF
rates NOUN I-LF
( PUNCT B-O
MIR PROPN B-AC
) PUNCT B-O
were AUX B-O
calculated VERB B-O
. PUNCT B-O

In ADP B-O
the DET B-O
case NOUN B-O
of ADP B-O
the DET B-O
Schizophrenia PROPN B-LF
( PUNCT B-O
SZ PROPN B-AC
) PUNCT B-O
GWAS PROPN B-AC
original ADJ B-O
report NOUN B-O
, PUNCT B-O
16 NUM B-O
% NOUN B-O
of ADP B-O
the DET B-O
findings NOUN B-O
were AUX B-O
shown VERB B-O
to PART B-O
have VERB B-O
brain NOUN B-O
eQTL PROPN B-AC
effects NOUN B-O
at ADP B-O
the DET B-O
gene NOUN B-O
level NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
, PUNCT B-O
but CCONJ B-O
further ADJ B-O
studies NOUN B-O
are AUX B-O
increasing VERB B-O
this DET B-O
number NOUN B-O
[ PUNCT B-O
6 NUM B-O
, PUNCT B-O
7 NUM B-O
] PUNCT B-O
. PUNCT B-O

To PART B-O
explore VERB B-O
the DET B-O
relationships NOUN B-O
between ADP B-O
HP1 PROPN B-AC
and CCONJ B-O
these DET B-O
marks NOUN B-O
, PUNCT B-O
we PRON B-O
re VERB B-O
- PUNCT B-O
analyzed VERB B-O
available ADJ B-O
high ADJ B-O
- PUNCT B-O
resolution NOUN B-O
chromosomal ADJ B-O
maps NOUN B-O
of ADP B-O
dimethylated VERB B-LF
histone NOUN I-LF
3 NUM I-LF
lysine NOUN I-LF
4 NUM I-LF
( PUNCT B-O
H3K4me2 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
H3.3 NOUN B-O
, PUNCT B-O
which PRON B-O
were AUX B-O
generated VERB B-O
in ADP B-O
the DET B-O
Drosophila PROPN B-O
Kc PROPN B-O
cell NOUN B-O
line NOUN B-O
or CCONJ B-O
in ADP B-O
the DET B-O
closely ADV B-O
related VERB B-O
S2 PROPN B-O
cell NOUN B-O
line NOUN B-O
[ X B-O
51,53 X B-O
] X B-O
( PUNCT B-O
see VERB B-O
Materials NOUN B-O
and CCONJ B-O
Methods PROPN B-O
) PUNCT B-O
. PUNCT B-O

This DET B-O
virus NOUN B-O
quickly ADV B-O
spread VERB B-O
globally ADV B-O
, PUNCT B-O
and CCONJ B-O
on ADP B-O
June PROPN B-O
11 NUM B-O
, PUNCT B-O
2009 NUM B-O
, PUNCT B-O
the DET B-O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WHO PROPN B-AC
) PUNCT B-O
declared VERB B-O
a DET B-O
pandemic NOUN B-O
alert NOUN B-O
phase NOUN B-O
6 NUM B-O
, PUNCT B-O
indicating VERB B-O
that SCONJ B-O
the DET B-O
first ADJ B-O
influenza NOUN B-O
pandemic NOUN B-O
of ADP B-O
the DET B-O
21st ADJ B-O
century NOUN B-O
had AUX B-O
begun VERB B-O
[ X B-O
1]–[3 X B-O
] PUNCT B-O
. PUNCT B-O

Between ADP B-O
1990 NUM B-O
and CCONJ B-O
2014 NUM B-O
the DET B-O
world NOUN B-O
prevalence NOUN B-O
of ADP B-O
cesarean ADJ B-LF
section NOUN I-LF
( PUNCT B-O
CS PROPN B-AC
) PUNCT B-O
increased VERB B-O
by ADP B-O
285 NUM B-O
% NOUN B-O
( PUNCT B-O
6.7 NUM B-O
% NOUN B-O
versus ADP B-O
19.1 NUM B-O
% NOUN B-O
of ADP B-O
all DET B-O
births NOUN B-O
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
, PUNCT B-O
albeit SCONJ B-O
with ADP B-O
large ADJ B-O
regional ADJ B-O
disparities NOUN B-O
. PUNCT B-O

Note VERB B-O
that SCONJ B-O
as ADP B-O
a DET B-O
consequence NOUN B-O
of ADP B-O
standardization NOUN B-O
of ADP B-O
the DET B-O
continuous ADJ B-O
variables NOUN B-O
( PUNCT B-O
age NOUN B-O
, PUNCT B-O
waist NOUN B-O
circumference NOUN B-O
, PUNCT B-O
fasting VERB B-O
plasma NOUN B-O
glucose NOUN B-O
, PUNCT B-O
total ADJ B-O
- PUNCT B-O
to ADP B-O
- PUNCT B-O
HDL NOUN B-O
cholesterol NOUN B-O
, PUNCT B-O
24 NUM B-O
- PUNCT B-O
h NOUN B-O
systolic ADJ B-O
blood NOUN B-O
pressure NOUN B-O
) PUNCT B-O
the DET B-O
regression NOUN B-O
coefficient NOUN B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
for ADP B-O
continuous ADJ B-O
variables NOUN B-O
equals VERB B-O
the DET B-O
standardized ADJ B-O
beta NOUN B-O
. PUNCT B-O

* PUNCT B-O
P<0.05 NUM B-O
, PUNCT B-O
SD PROPN B-AC
, PUNCT B-O
standard ADJ B-LF
deviation NOUN I-LF
; PUNCT B-O
CI NOUN B-O
, PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
; PUNCT B-O
HDL NOUN B-O
, PUNCT B-O
high ADJ B-O
- PUNCT B-O
density NOUN B-O
lipoprotein NOUN B-O
. PUNCT B-O

For ADP B-O
this DET B-O
interim ADJ B-O
analysis NOUN B-O
, PUNCT B-O
we PRON B-O
excluded VERB B-O
patients NOUN B-O
treated VERB B-O
with ADP B-O
different ADJ B-O
therapies NOUN B-O
other ADJ B-O
than ADP B-O
standard ADJ B-O
chemotherapy NOUN B-O
including VERB B-O
anthracycline NOUN B-O
and/or CCONJ B-O
trastuzumab NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
2,929 NUM B-O
) PUNCT B-O
, PUNCT B-O
patients NOUN B-O
with ADP B-O
no DET B-O
left ADJ B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
( PUNCT B-O
LVEF PROPN B-AC
) PUNCT B-O
measurement NOUN B-O
at ADP B-O
baseline NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
918)or NUM B-O
no DET B-O
available ADJ B-O
follow VERB B-O
- PUNCT B-O
up ADP B-O
measurements NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
799 NUM B-O
) PUNCT B-O
, PUNCT B-O
patients NOUN B-O
with ADP B-O
LVEF PROPN B-AC
at ADP B-O
baseline NOUN B-O
< ADP B-O
50 NUM B-O
% NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
13 NUM B-O
) PUNCT B-O
, PUNCT B-O
patients NOUN B-O
with ADP B-O
BMI PROPN B-AC
< ADP B-O
18.5 NUM B-O
kg NOUN B-O
/ SYM B-O
m2 NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
32 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
patients NOUN B-O
with ADP B-O
evidence NOUN B-O
of ADP B-O
local ADJ B-O
, PUNCT B-O
regional ADJ B-O
, PUNCT B-O
or CCONJ B-O
metastatic ADJ B-O
recurrence NOUN B-O
of ADP B-O
BC PROPN B-AC
( PUNCT B-O
n NOUN B-O
= SYM B-O
181 NUM B-O
) PUNCT B-O
. PUNCT B-O

Meanwhile ADV B-O
, PUNCT B-O
it PRON B-O
lowered VERB B-O
malondialdehyde NOUN B-LF
( PUNCT B-O
MDA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
nitric NOUN B-LF
oxide NOUN I-LF
( PUNCT B-O
NO PROPN B-AC
) PUNCT B-O
and CCONJ B-O
nuclear ADJ B-LF
factor NOUN I-LF
erythroid NOUN I-LF
2 NUM I-LF
- PUNCT I-LF
related VERB I-LF
factor NOUN I-LF
2 NUM I-LF
( PUNCT B-O
NRF-2 PROPN B-AC
) PUNCT B-O
levels NOUN B-O
with ADP B-O
restoration NOUN B-O
of ADP B-O
glutathione NOUN B-LF
( PUNCT B-O
GSH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
glutathione NOUN B-LF
peroxidase NOUN I-LF
( PUNCT B-O
GPx PROPN B-AC
) PUNCT B-O
. PUNCT B-O

CD PROPN B-AC
, PUNCT B-O
change NOUN B-LF
- PUNCT I-LF
detection NOUN I-LF
. PUNCT B-O

As SCONJ B-O
the DET B-O
transfer NOUN B-O
of ADP B-O
bacteria NOUN B-O
to ADP B-O
the DET B-O
embryo NOUN B-O
is AUX B-O
being AUX B-O
completed VERB B-O
, PUNCT B-O
expression NOUN B-O
of ADP B-O
the DET B-O
Engrailed PROPN B-LF
( PUNCT B-O
En PROPN B-AC
) PUNCT B-O
protein NOUN B-O
( PUNCT B-O
FBgn0000577 NOUN B-O
) PUNCT B-O
( PUNCT B-O
Patel PROPN B-O
et NOUN B-O
al NOUN B-O
. PUNCT B-O

1989 NUM B-O
) PUNCT B-O
is AUX B-O
detected VERB B-O
( PUNCT B-O
Figure NOUN B-O
1 NUM B-O
G NOUN B-O
) PUNCT B-O
. PUNCT B-O

Knowledge NOUN B-LF
translation NOUN I-LF
( PUNCT B-O
KT PROPN B-AC
) PUNCT B-O
is AUX B-O
one NUM B-O
of ADP B-O
a DET B-O
host NOUN B-O
of ADP B-O
terms NOUN B-O
( PUNCT B-O
e.g. X B-O
, PUNCT B-O
implementation NOUN B-O
, PUNCT B-O
knowledge NOUN B-O
transfer NOUN B-O
) PUNCT B-O
used VERB B-O
to PART B-O
describe VERB B-O
“ PUNCT B-O
a DET B-O
dynamic ADJ B-O
and CCONJ B-O
iterative ADJ B-O
process NOUN B-O
that PRON B-O
includes VERB B-O
the DET B-O
synthesis NOUN B-O
, PUNCT B-O
dissemination NOUN B-O
, PUNCT B-O
exchange NOUN B-O
and CCONJ B-O
ethically ADV B-O
sound ADJ B-O
application NOUN B-O
of ADP B-O
knowledge NOUN B-O
to PART B-O
improve VERB B-O
health NOUN B-O
, PUNCT B-O
provide VERB B-O
more ADV B-O
effective ADJ B-O
health NOUN B-O
services NOUN B-O
and CCONJ B-O
products NOUN B-O
, PUNCT B-O
and CCONJ B-O
strengthen VERB B-O
the DET B-O
healthcare NOUN B-O
system NOUN B-O
. PUNCT B-O

”[6 X B-O
] X B-O
This DET B-O
value NOUN B-O
is AUX B-O
in ADP B-O
excellent ADJ B-O
agreement NOUN B-O
with ADP B-O
the DET B-O
expected VERB B-O
molecular ADJ B-O
weight NOUN B-O
of ADP B-O
the DET B-O
holoenzyme NOUN B-O
, PUNCT B-O
28,705.88 NUM B-O
Da PROPN B-AC
. PUNCT B-O

As ADP B-O
an DET B-O
independent ADJ B-O
confirmation NOUN B-O
of ADP B-O
these DET B-O
results NOUN B-O
, PUNCT B-O
an DET B-O
electrospray NOUN B-LF
ionization NOUN I-LF
( PUNCT B-O
ESI PROPN B-AC
) PUNCT B-O
mass NOUN B-O
spectrum NOUN B-O
was AUX B-O
acquired VERB B-O
for ADP B-O
APS PROPN B-AC
reductase NOUN B-O
. PUNCT B-O

Real ADJ B-O
- PUNCT B-O
time NOUN B-O
reverse ADJ B-O
transcription NOUN B-O
PCR NOUN B-O
( PUNCT B-O
qPCR NOUN B-O
) PUNCT B-O
normalized VERB B-O
to ADP B-O
an DET B-O
internal ADJ B-O
reference NOUN B-LF
gene NOUN I-LF
( PUNCT B-O
RG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
is AUX B-O
a DET B-O
frequently ADV B-O
used VERB B-O
method NOUN B-O
for ADP B-O
quantifying VERB B-O
gene NOUN B-O
expression NOUN B-O
changes NOUN B-O
in ADP B-O
neuroscience NOUN B-O
. PUNCT B-O

Consensus NOUN B-O
documents NOUN B-O
developed VERB B-O
by ADP B-O
professional ADJ B-O
societies NOUN B-O
from ADP B-O
the DET B-O
US PROPN B-O
, PUNCT B-O
Europe PROPN B-O
, PUNCT B-O
and CCONJ B-O
Canada PROPN B-O
[ X B-O
9–12 NUM B-O
] X B-O
have AUX B-O
cautioned VERB B-O
against ADP B-O
generic ADJ B-O
immunosuppressant ADJ B-O
use NOUN B-O
, PUNCT B-O
citing VERB B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
the DET B-O
lack NOUN B-O
of ADP B-O
data NOUN B-O
in ADP B-O
transplant NOUN B-O
recipients NOUN B-O
, PUNCT B-O
especially ADV B-O
“ PUNCT B-O
high ADJ B-O
risk NOUN B-O
” PUNCT B-O
transplant NOUN B-O
recipients NOUN B-O
; PUNCT B-O
( PUNCT B-O
2 X B-O
) PUNCT B-O
the DET B-O
need NOUN B-O
to PART B-O
implement VERB B-O
stricter ADJ B-O
bioequivalence NOUN B-O
standards NOUN B-O
, PUNCT B-O
as SCONJ B-O
tacrolimus PROPN B-O
is AUX B-O
a DET B-O
narrow ADJ B-LF
therapeutic ADJ I-LF
index NOUN I-LF
( PUNCT B-O
NTI PROPN B-AC
) PUNCT B-O
drug NOUN B-O
for ADP B-O
which PRON B-O
small ADJ B-O
changes NOUN B-O
in ADP B-O
dose NOUN B-O
or CCONJ B-O
exposure NOUN B-O
can AUX B-O
result VERB B-O
in ADP B-O
therapeutic ADJ B-O
failure NOUN B-O
or CCONJ B-O
toxicity NOUN B-O
; PUNCT B-O
and CCONJ B-O
( PUNCT B-O
3 X B-O
) PUNCT B-O
the DET B-O
lack NOUN B-O
of ADP B-O
bioequivalence NOUN B-O
data NOUN B-O
between ADP B-O
generics NOUN B-O
. PUNCT B-O

Ductal ADJ B-LF
carcinoma NOUN I-LF
in ADP I-LF
situ NOUN I-LF
( PUNCT B-O
DCIS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
noninvasive ADJ B-O
nonobligate ADJ B-O
precursor NOUN B-O
of ADP B-O
breast NOUN B-O
cancer NOUN B-O
, PUNCT B-O
accounts VERB B-O
for ADP B-O
about ADV B-O
25 NUM B-O
% NOUN B-O
of ADP B-O
all DET B-O
breast NOUN B-O
cancer NOUN B-O
cases NOUN B-O
[ PUNCT B-O
38 NUM B-O
] PUNCT B-O
. PUNCT B-O

Indeed ADV B-O
, PUNCT B-O
as SCONJ B-O
expected VERB B-O
, PUNCT B-O
pretreatment NOUN B-O
of ADP B-O
Hsp26 PROPN B-O
for ADP B-O
10 NUM B-O
min NOUN B-O
at ADP B-O
45 NUM B-O
° NOUN B-O
C NOUN B-O
increased VERB B-O
the DET B-O
ability NOUN B-O
of ADP B-O
Hsp26 PROPN B-O
to ADP B-O
suppress VERB B-O
aggregation NOUN B-O
of ADP B-O
glutamate NOUN B-LF
dehydrogenase NOUN I-LF
( PUNCT B-O
GDH PROPN B-AC
) PUNCT B-O
( PUNCT B-O
Figure PROPN B-O
6D NUM B-O
) PUNCT B-O
. PUNCT B-O

By ADP B-O
contrast NOUN B-O
, PUNCT B-O
the DET B-O
same ADJ B-O
pretreatment NOUN B-O
reduced VERB B-O
the DET B-O
ability NOUN B-O
of ADP B-O
Hsp26 PROPN B-O
to ADP B-O
inhibit VERB B-O
spontaneous ADJ B-O
NM NOUN B-O
assembly NOUN B-O
( PUNCT B-O
Figure PROPN B-O
6D NUM B-O
) PUNCT B-O
. PUNCT B-O

Thus ADV B-O
, PUNCT B-O
at ADP B-O
elevated VERB B-O
temperatures NOUN B-O
Hsp26 PROPN B-O
might AUX B-O
switch VERB B-O
from ADP B-O
inhibiting VERB B-O
prion NOUN B-O
assembly NOUN B-O
to ADP B-O
suppressing VERB B-O
aggregation NOUN B-O
of ADP B-O
denatured VERB B-O
substrates NOUN B-O
. PUNCT B-O

The DET B-O
results NOUN B-O
demonstrated VERB B-O
that SCONJ B-O
this DET B-O
human ADJ B-O
LCM PROPN B-AC
gene NOUN B-O
set NOUN B-O
was AUX B-O
significantly ADV B-O
decreased VERB B-O
in ADP B-O
the DET B-O
STHdhQ111 NOUN B-O
/ SYM B-O
Q111 NOUN B-O
cells NOUN B-O
( PUNCT B-O
enrichment NOUN B-LF
score NOUN I-LF
[ X B-O
ES PROPN B-AC
] X B-O
0.51 NUM B-O
, PUNCT B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
0.000 NUM B-O
, PUNCT B-O
FDR PROPN B-AC
q NOUN B-O
- NOUN B-O
value NOUN B-O
0.180 NUM B-O
) PUNCT B-O
but CCONJ B-O
was AUX B-O
not PART B-O
altered VERB B-O
in ADP B-O
the DET B-O
3 PROPN B-AC
treated VERB B-O
cells NOUN B-O
( PUNCT B-O
-NPES PROPN B-AC
0.38 NUM B-O
, PUNCT B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
0.271 NUM B-O
, PUNCT B-O
FDR PROPN B-AC
q NOUN B-O
- NOUN B-O
value NOUN B-O
0.713 NUM B-O
) PUNCT B-O
. PUNCT B-O

BP PROPN B-AC
: PUNCT B-O
blood NOUN B-LF
pressure NOUN I-LF
. PUNCT B-O

In ADP B-O
pemphigus NOUN B-LF
vulgaris PROPN I-LF
( PUNCT B-O
PV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
most ADV B-O
common ADJ B-O
clinical ADJ B-O
variant NOUN B-O
of ADP B-O
pemphigus NOUN B-O
, PUNCT B-O
several ADJ B-O
in ADP B-O
vitro ADJ B-O
and CCONJ B-O
in ADP B-O
vivo ADJ B-O
studies NOUN B-O
demonstrated VERB B-O
the DET B-O
critical ADJ B-O
role NOUN B-O
of ADP B-O
Dsg3 NOUN B-O
- NOUN B-O
specific ADJ B-O
CD4 NOUN B-O
+ NOUN B-O
T NOUN B-O
cells NOUN B-O
in ADP B-O
the DET B-O
generation NOUN B-O
of ADP B-O
Dsg3 NOUN B-O
- NOUN B-O
specific ADJ B-O
auto-ab PROPN B-AC
[ X B-O
4–9 NUM B-O
] PUNCT B-O
. PUNCT B-O

I PRON B-O
employed VERB B-O
a DET B-O
Z NOUN B-O
- PUNCT B-O
score NOUN B-O
measure NOUN B-O
of ADP B-O
structural ADJ B-O
proximity NOUN B-O
as ADP B-O
weight NOUN B-O
for ADP B-O
the DET B-O
edges NOUN B-O
to PART B-O
create VERB B-O
a DET B-O
protein NOUN B-LF
domains NOUN I-LF
universe NOUN I-LF
graph NOUN I-LF
( PUNCT B-O
PDUG PROPN B-AC
[ PUNCT B-O
19 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
VHL PROPN B-AC
mutation NOUN B-O
diminishes VERB B-O
VHL PROPN B-AC
's PART B-O
binding VERB B-O
affinity NOUN B-O
for ADP B-O
hydroxylated VERB B-O
HIF PROPN B-AC
- PUNCT B-O
α PUNCT B-O
, PUNCT B-O
thereby ADV B-O
partially ADV B-O
inhibiting VERB B-O
HIF PROPN B-AC
- PUNCT B-O
α PUNCT B-O
degradation NOUN B-O
and CCONJ B-O
pathologically ADV B-O
up ADV B-O
- PUNCT B-O
regulating VERB B-O
HIF PROPN B-AC
target NOUN B-O
genes NOUN B-O
including VERB B-O
erythropoietin NOUN B-LF
( PUNCT B-O
EPO PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
8 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
HR NOUN B-O
, PUNCT B-O
hazard NOUN B-O
ratio NOUN B-O
; PUNCT B-O
ICS PROPN B-AC
, PUNCT B-O
inhaled VERB B-LF
corticosteroid NOUN I-LF
; PUNCT B-O
LABA PROPN B-AC
, PUNCT B-O
long ADV B-LF
- PUNCT I-LF
acting VERB I-LF
beta NOUN I-LF
- PUNCT I-LF
agonist NOUN I-LF
. PUNCT B-O

Information NOUN B-O
is AUX B-O
available ADJ B-O
from ADP B-O
Avert PROPN B-O
, PUNCT B-O
an DET B-O
international ADJ B-O
AIDS PROPN B-O
charity NOUN B-O
, PUNCT B-O
on ADP B-O
many ADJ B-O
aspects NOUN B-O
of ADP B-O
HIV PROPN B-O
/ SYM B-O
AIDS PROPN B-O
, PUNCT B-O
including VERB B-O
information NOUN B-O
on ADP B-O
antiretroviral ADJ B-LF
drugs NOUN B-O
and CCONJ B-O
on ADP B-O
universal ADJ B-O
access NOUN B-O
to ADP B-O
ARV PROPN B-AC
therapy NOUN B-O
; PUNCT B-O
Avert PROPN B-O
also ADV B-O
provides VERB B-O
personal ADJ B-O
stories NOUN B-O
about ADP B-O
living VERB B-O
with ADP B-O
HIV PROPN B-O
/ SYM B-O
AIDS PROPN B-O
The DET B-O
efficiency NOUN B-O
of ADP B-O
siRNA NOUN B-O
delivery NOUN B-O
was AUX B-O
checked VERB B-O
with ADP B-O
fluorescent ADJ B-O
siGLO NOUN B-O
. PUNCT B-O

Among ADP B-O
these DET B-O
siRNAs NOUN B-O
, PUNCT B-O
only ADV B-O
those PRON B-O
silencing VERB B-O
the DET B-O
Ca2 NOUN B-O
+ NOUN B-O
-independent ADJ B-O
Group PROPN B-LF
VIIIA PROPN I-LF
( PUNCT B-O
GVIIIA)-PLA2 PROPN B-AC
inhibited VERB B-O
VSVG PROPN B-AC
transport NOUN B-O
, PUNCT B-O
resulting VERB B-O
in ADP B-O
accumulation NOUN B-O
of ADP B-O
cargo NOUN B-O
within ADP B-O
the DET B-O
Golgi PROPN B-O
complex NOUN B-O
( PUNCT B-O
Figure NOUN B-O
8L NUM B-O
and CCONJ B-O
8P NOUN B-O
) PUNCT B-O
. PUNCT B-O

Strikingly ADV B-O
, PUNCT B-O
this DET B-O
PLA2 PROPN B-AC
isoform NOUN B-O
has AUX B-O
been AUX B-O
detected VERB B-O
by ADP B-O
others NOUN B-O
at ADP B-O
the DET B-O
Golgi PROPN B-O
membranes NOUN B-O
and CCONJ B-O
appears VERB B-O
to PART B-O
be AUX B-O
important ADJ B-O
for ADP B-O
maintenance NOUN B-O
of ADP B-O
the DET B-O
tubular ADJ B-O
elements NOUN B-O
of ADP B-O
the DET B-O
Golgi PROPN B-O
complex NOUN B-O
( PUNCT B-O
W. PROPN B-O
The DET B-O
main ADJ B-O
outcome NOUN B-O
is AUX B-O
whether SCONJ B-O
baseline NOUN B-O
participants NOUN B-O
received VERB B-O
RPC PROPN B-AC
( PUNCT B-O
includes VERB B-O
both CCONJ B-O
pan ADJ B-O
- PUNCT B-O
retinal ADJ B-LF
photocoagulation NOUN I-LF
and CCONJ B-O
focal ADJ B-O
retinal ADJ B-O
treatment NOUN B-O
for ADP B-O
macular ADJ B-O
edema NOUN B-O
) PUNCT B-O
during ADP B-O
the DET B-O
follow NOUN B-O
- PUNCT B-O
up ADP B-O
period NOUN B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
an DET B-O
indicator NOUN B-O
of ADP B-O
progression NOUN B-O
to ADP B-O
sNPDR PROPN B-AC
or CCONJ B-O
PDR PROPN B-AC
. PUNCT B-O

A DET B-O
participant NOUN B-O
who PRON B-O
had AUX B-O
at ADV B-O
least ADV B-O
one NUM B-O
retinal ADJ B-O
laser NOUN B-O
treatment NOUN B-O
record NOUN B-O
in ADP B-O
the DET B-O
MBS PROPN B-AC
database NOUN B-O
( PUNCT B-O
MBS PROPN B-AC
code NOUN B-O
for ADP B-O
RPC PROPN B-AC
: PUNCT B-O
42809 NUM B-O
) PUNCT B-O
were AUX B-O
defined VERB B-O
as SCONJ B-O
had AUX B-O
undergone VERB B-O
RPC PROPN B-AC
. PUNCT B-O

The DET B-O
date NOUN B-O
of ADP B-O
first ADJ B-O
laser NOUN B-O
treatment NOUN B-O
was AUX B-O
utilized VERB B-O
for ADP B-O
analysis NOUN B-O
if SCONJ B-O
the DET B-O
patient NOUN B-O
underwent VERB B-O
multiple ADJ B-O
RPC PROPN B-AC
treatments NOUN B-O
. PUNCT B-O

Chronic ADJ B-O
airflow NOUN B-O
limitation NOUN B-O
was AUX B-O
defined VERB B-O
as ADP B-O
FEV1 PROPN B-AC
/ SYM B-O
FVC PROPN B-AC
below ADP B-O
the DET B-O
5th ADJ B-O
percentile NOUN B-O
( PUNCT B-O
lower ADJ B-O
limit NOUN B-O
of ADP B-O
normal ADJ B-O
; PUNCT B-O
LLN PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Diffusing VERB B-LF
lung NOUN I-LF
capacity NOUN I-LF
for ADP I-LF
carbon NOUN I-LF
monoxide NOUN I-LF
( PUNCT B-O
DLCO PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
DLCO PROPN B-AC
corrected VERB B-O
for ADP B-O
lung NOUN B-O
volume NOUN B-O
( PUNCT B-O
DLCO PROPN B-AC
) PUNCT B-O
were AUX B-O
measured VERB B-O
using VERB B-O
a DET B-O
single ADJ B-O
breath NOUN B-O
carbon NOUN B-O
monoxide NOUN B-O
diffusion NOUN B-O
test NOUN B-O
and CCONJ B-O
were AUX B-O
adjusted VERB B-O
for ADP B-O
plasma NOUN B-O
haemoglobin NOUN B-O
level.[20 NOUN B-O
] X B-O
Inspiratory ADJ B-LF
capacity NOUN I-LF
( PUNCT B-O
/VAIC PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
as ADP B-O
the DET B-O
total ADJ B-LF
lung NOUN I-LF
capacity NOUN I-LF
( PUNCT B-O
TLC PROPN B-AC
) PUNCT B-O
minus CCONJ B-O
the DET B-O
functional ADJ B-LF
residual ADJ I-LF
capacity NOUN I-LF
( PUNCT B-O
FRC PROPN B-AC
) PUNCT B-O
. PUNCT B-O

All DET B-O
lung NOUN B-O
function NOUN B-O
measures NOUN B-O
were AUX B-O
expressed VERB B-O
as ADP B-O
absolute ADJ B-O
values NOUN B-O
and CCONJ B-O
relative ADJ B-O
values NOUN B-O
( PUNCT B-O
percentage NOUN B-O
of ADP B-O
predicted VERB B-O
; PUNCT B-O
% NOUN B-O
pred).[20–24 X B-O
] X B-O
The DET B-O
extent NOUN B-O
of ADP B-O
dysanapsis NOUN B-O
was AUX B-O
calculated VERB B-O
using VERB B-O
the DET B-O
formula NOUN B-O
of ADP B-O
Mead PROPN B-O
et PROPN B-O
al.[8 X B-O
, PUNCT B-O
9 NUM B-O
, PUNCT B-O
25 NUM B-O
] X B-O
Results NOUN B-O
from ADP B-O
the DET B-O
PSA PROPN B-AC
give VERB B-O
slightly ADV B-O
greater ADJ B-O
mean ADJ B-O
effects NOUN B-O
for ADP B-O
both CCONJ B-O
the DET B-O
routine ADJ B-O
/ SYM B-O
manual ADJ B-O
( PUNCT B-O
current ADJ B-O
tax NOUN B-O
increase NOUN B-O
, NOUN B-O
−3.6 NUM B-O
% NOUN B-O
[ PUNCT B-O
95 NUM B-O
% NOUN B-O
uncertainty NOUN B-LF
interval NOUN I-LF
( PUNCT B-O
UI PROPN B-AC
) PUNCT B-O
−6.1 NUM B-O
% NOUN B-O
, NOUN B-O
−0.6 NUM B-O
% NOUN B-O
] PUNCT B-O
; PUNCT B-O
value NOUN B-O
- PUNCT B-O
based VERB B-O
tax NOUN B-O
, NOUN B-O
−3.3 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−5.1 NUM B-O
% NOUN B-O
, NOUN B-O
−1.7 NUM B-O
% NOUN B-O
] PUNCT B-O
; PUNCT B-O
strength NOUN B-O
- PUNCT B-O
based VERB B-O
tax NOUN B-O
, NOUN B-O
−7.5 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−13.7 NUM B-O
% NOUN B-O
, NOUN B-O
−3.9 NUM B-O
% NOUN B-O
] PUNCT B-O
; PUNCT B-O
minimum ADJ B-O
unit NOUN B-O
pricing NOUN B-O
, NOUN B-O
−10.3 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−10.3 NUM B-O
% NOUN B-O
, NOUN B-O
−7.0 NUM B-O
% NOUN B-O
] PUNCT B-O
) PUNCT B-O
and CCONJ B-O
professional ADJ B-O
/ SYM B-O
managerial ADJ B-O
occupation NOUN B-O
groups NOUN B-O
( PUNCT B-O
current ADJ B-O
tax NOUN B-O
increase NOUN B-O
, NOUN B-O
−1.8 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−4.7 NUM B-O
% NOUN B-O
, NOUN B-O
+1.6 NUM B-O
% NOUN B-O
] PUNCT B-O
; PUNCT B-O
value NOUN B-O
- PUNCT B-O
based VERB B-O
tax NOUN B-O
, NOUN B-O
−1.9 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−3.6 NUM B-O
% NOUN B-O
, NOUN B-O
+0.4 NUM B-O
% NOUN B-O
] PUNCT B-O
; PUNCT B-O
strength NOUN B-O
- PUNCT B-O
based VERB B-O
tax NOUN B-O
, NOUN B-O
−0.8 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−6.9 NUM B-O
% NOUN B-O
, NOUN B-O
+4.0 NUM B-O
% NOUN B-O
] PUNCT B-O
; PUNCT B-O
minimum ADJ B-O
unit NOUN B-O
pricing NOUN B-O
, NOUN B-O
−0.7 NUM B-O
% NOUN B-O
[ PUNCT B-O
UI PROPN B-AC
−5.6 NUM B-O
% NOUN B-O
, NOUN B-O
+3.6 NUM B-O
% NOUN B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Chronic ADJ B-O
hepatitis NOUN B-LF
C PROPN I-LF
virus NOUN I-LF
( PUNCT B-O
HCV PROPN B-AC
) PUNCT B-O
infection NOUN B-O
is AUX B-O
a DET B-O
leading VERB B-O
cause NOUN B-O
of ADP B-O
cirrhosis NOUN B-O
, PUNCT B-O
liver NOUN B-O
failure NOUN B-O
, PUNCT B-O
and CCONJ B-O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
( PUNCT B-O
HCC PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
, PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

DUSP1 PROPN B-AC
has AUX B-O
been AUX B-O
shown VERB B-O
to PART B-O
attenuate VERB B-O
MAPK PROPN B-AC
signaling NOUN B-O
, PUNCT B-O
effectively ADV B-O
reducing VERB B-O
osteolysis NOUN B-O
and CCONJ B-O
cartilage NOUN B-O
degeneration NOUN B-O
in ADP B-O
studies NOUN B-O
utilizing VERB B-O
mouse NOUN B-O
models NOUN B-O
of ADP B-O
lipopolysaccharide NOUN B-O
( PUNCT B-O
LPS PROPN B-AC
) PUNCT B-O
induced VERB B-O
inflammatory ADJ B-O
bone NOUN B-O
loss NOUN B-O
and CCONJ B-O
collagen NOUN B-LF
induced VERB I-LF
arthritis NOUN I-LF
( PUNCT B-O
CIA PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
16,19,20 NUM B-O
] PUNCT B-O
. PUNCT B-O

Genomic ADJ B-O
DNA PROPN B-O
was AUX B-O
extracted VERB B-O
from ADP B-O
young ADJ B-O
leaves NOUN B-O
of ADP B-O
these DET B-O
above ADV B-O
mentioned VERB B-O
accessions NOUN B-O
using VERB B-O
a DET B-O
modified VERB B-O
cetyltrimethyl NOUN B-LF
ammonium NOUN I-LF
bromide NOUN I-LF
( PUNCT B-O
CTAB PROPN B-AC
) PUNCT B-O
method NOUN B-O
. PUNCT B-O

The DET B-O
median ADJ B-O
age NOUN B-O
at ADP B-O
first ADJ B-O
admission NOUN B-O
was AUX B-O
6 NUM B-O
months NOUN B-O
( PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
[ X B-O
IQR PROPN B-AC
] X B-O
2–14 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
commonest ADJ B-O
code NOUN B-O
linked VERB B-O
to ADP B-O
the DET B-O
first ADJ B-O
and CCONJ B-O
all DET B-O
admissions NOUN B-O
was AUX B-O
urinary ADJ B-LF
tract NOUN I-LF
infection NOUN I-LF
( PUNCT B-O
UTI PROPN B-AC
; PUNCT B-O
ICD-10 PROPN B-AC
codes NOUN B-O
N39.0 NUM B-O
, PUNCT B-O
N39.1 NUM B-O
, PUNCT B-O
or CCONJ B-O
P39.3 NUM B-O
) PUNCT B-O
. PUNCT B-O

RS PROPN B-AC
: PUNCT B-O
retrospective ADJ B-LF
. PUNCT B-O

These DET B-O
two NUM B-O
regions NOUN B-O
of ADP B-O
the DET B-O
VE PROPN B-AC
also ADV B-O
show VERB B-O
differences NOUN B-O
in ADP B-O
localisation NOUN B-O
of ADP B-O
the DET B-O
molecular ADJ B-O
motors NOUN B-O
F PROPN B-O
- NOUN B-O
actin NOUN B-O
and CCONJ B-O
Myosin PROPN B-O
IIA PROPN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
Planar PROPN B-LF
Cell PROPN I-LF
Polarity PROPN I-LF
( PUNCT B-O
PCP PROPN B-AC
) PUNCT B-O
signalling NOUN B-O
molecules NOUN B-O
Dishevelled-2 PROPN B-LF
( PUNCT B-O
Dvl-2 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Vangl2 PROPN B-O
[ PUNCT B-O
20 NUM B-O
] PUNCT B-O
. PUNCT B-O

Human ADJ B-O
and CCONJ B-O
mouse NOUN B-O
B PROPN B-O
cells NOUN B-O
were AUX B-O
activated VERB B-O
with ADP B-O
membrane NOUN B-O
- PUNCT B-O
tethered VERB B-O
or CCONJ B-O
soluble ADJ B-O
mB PROPN B-O
- PUNCT B-O
Fab′–anti NOUN B-O
- PUNCT B-O
Ig NOUN B-O
plus CCONJ B-O
streptavidin NOUN B-O
before ADP B-O
staining VERB B-O
for ADP B-O
phosphorylated VERB B-LF
WASP NOUN I-LF
WASP PROPN B-AC
( PUNCT B-O
pWASP PROPN B-AC
) PUNCT B-O
and CCONJ B-O
N-WASP PROPN B-AC
( PUNCT B-O
pN PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Using VERB B-O
total ADJ B-O
internal ADJ B-O
reflection NOUN B-O
fluorescence NOUN B-O
microscopy NOUN B-O
( PUNCT B-O
TIRFM PROPN B-O
) PUNCT B-O
, PUNCT B-O
we PRON B-O
analyzed VERB B-O
the DET B-O
distribution NOUN B-O
and CCONJ B-O
the DET B-O
relative ADJ B-O
levels NOUN B-O
of ADP B-O
-WASPpWASP PROPN B-AC
and CCONJ B-O
pN PROPN B-AC
at ADP B-O
the DET B-O
surface NOUN B-O
of ADP B-O
B PROPN B-O
cells NOUN B-O
in ADP B-O
contact NOUN B-O
with ADP B-O
the DET B-O
mB PROPN B-O
- PUNCT B-O
Fab′–anti NOUN B-O
- PUNCT B-O
Ig NOUN B-O
– PUNCT B-O
tethered VERB B-O
lipid NOUN B-O
bilayer NOUN B-O
( PUNCT B-O
B PROPN B-O
- PUNCT B-O
cell NOUN B-O
contact NOUN B-O
zone NOUN B-O
) PUNCT B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
is AUX B-O
reported VERB B-O
as ADP B-O
per ADP B-O
the DET B-O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT B-O
STROBE PROPN B-AC
) PUNCT B-O
guidelines NOUN B-O
( PUNCT B-O
S1 PROPN B-O
STROBE PROPN B-AC
Checklist PROPN B-O
) PUNCT B-O
. PUNCT B-O

SARS PROPN B-AC
-CoV-2 PROPN B-AC
entry NOUN B-O
into ADP B-O
cells NOUN B-O
depends VERB B-O
on ADP B-O
the DET B-O
binding NOUN B-O
of ADP B-O
the DET B-O
viral ADJ B-O
spike NOUN B-O
( PUNCT B-O
S NOUN B-O
) PUNCT B-O
protein NOUN B-O
to ADP B-O
its PRON B-O
cognate NOUN B-O
receptor NOUN B-O
angiotensin NOUN B-LF
converting VERB I-LF
enzyme NOUN I-LF
II NUM I-LF
( PUNCT B-O
ACE2 PROPN B-AC
) PUNCT B-O
on ADP B-O
the DET B-O
cell NOUN B-O
surface NOUN B-O
[ X B-O
6,10 NUM B-O
] PUNCT B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
is AUX B-O
reported VERB B-O
as ADP B-O
per ADP B-O
the DET B-O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT B-O
STROBE PROPN B-AC
) PUNCT B-O
guidelines NOUN B-O
( PUNCT B-O
S1 PROPN B-O
STROBE PROPN B-AC
Checklist PROPN B-O
) PUNCT B-O
[ PUNCT B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

As ADP B-O
a DET B-O
first ADJ B-O
line NOUN B-O
, PUNCT B-O
countries NOUN B-O
should AUX B-O
follow VERB B-O
Food PROPN B-LF
and CCONJ I-LF
Agriculture PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
FAO PROPN B-AC
) PUNCT B-O
advice NOUN B-O
[ X B-O
6 X B-O
] X B-O
and CCONJ B-O
withdraw VERB B-O
the DET B-O
most ADV B-O
toxic ADJ B-O
WHO PROPN B-AC
/ SYM B-O
US PROPN B-O
Environmental PROPN B-LF
Protection PROPN I-LF
Agency PROPN I-LF
( PUNCT B-O
EPA PROPN B-AC
) PUNCT B-O
class NOUN B-O
I NUM B-O
pesticides NOUN B-O
( PUNCT B-O
see VERB B-O
Table NOUN B-O
1 NUM B-O
for ADP B-O
description NOUN B-O
of ADP B-O
toxicity NOUN B-O
classifications NOUN B-O
) PUNCT B-O
from ADP B-O
agricultural ADJ B-O
practice NOUN B-O
. PUNCT B-O

Patients NOUN B-O
underwent VERB B-O
our PRON B-O
standardized ADJ B-O
diagnostic ADJ B-O
protocol NOUN B-O
encompassing VERB B-O
clinical ADJ B-O
evaluation NOUN B-O
with ADP B-O
assessment NOUN B-O
of ADP B-O
subjective ADJ B-O
sleepiness NOUN B-O
by ADP B-O
means NOUN B-O
of ADP B-O
Epworth PROPN B-LF
Sleepiness PROPN I-LF
Scale PROPN I-LF
( PUNCT B-O
ESS PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
24 NUM B-O
] PUNCT B-O
, PUNCT B-O
cerebral ADJ B-O
magnetic ADJ B-O
resonance NOUN B-O
imaging NOUN B-O
, PUNCT B-O
hospitalization NOUN B-O
with ADP B-O
48 NUM B-O
- PUNCT B-O
hr NOUN B-O
continuous ADJ B-O
polysomnographic ADJ B-O
recording NOUN B-O
, PUNCT B-O
Multiple PROPN B-LF
Sleep PROPN I-LF
Latency PROPN I-LF
Test PROPN I-LF
( PUNCT B-O
MSLT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
cataplexy NOUN B-O
video NOUN B-O
- PUNCT B-O
documentation NOUN B-O
, PUNCT B-O
human ADJ B-LF
leukocyte NOUN I-LF
antigen NOUN I-LF
( PUNCT B-O
HLA PROPN B-AC
) PUNCT B-O
typing NOUN B-O
and CCONJ B-O
lumbar NOUN B-O
puncture NOUN B-O
for ADP B-O
CSF PROPN B-O
Hcrt-1 PROPN B-AC
assay NOUN B-O
[ PUNCT B-O
25 NUM B-O
] PUNCT B-O
. PUNCT B-O

Although SCONJ B-O
none NOUN B-O
were AUX B-O
capable ADJ B-O
of ADP B-O
complete ADJ B-O
control NOUN B-O
, PUNCT B-O
all DET B-O
policies NOUN B-O
substantially ADV B-O
reduced VERB B-O
IAR PROPN B-AC
. PUNCT B-O

The DET B-O
baseline ADJ B-O
IAR PROPN B-AC
of ADP B-O
74 NUM B-O
% NOUN B-O
was AUX B-O
reduced VERB B-O
to ADP B-O
49 NUM B-O
% NOUN B-O
when SCONJ B-O
voluntary ADJ B-LF
household NOUN I-LF
quarantine NOUN I-LF
( PUNCT B-O
Q PROPN B-AC
) PUNCT B-O
alone ADV B-O
was AUX B-O
in ADP B-O
effect NOUN B-O
. PUNCT B-O

Stevens PROPN B-LF
- PUNCT I-LF
Johnson PROPN I-LF
syndrome NOUN I-LF
( PUNCT B-O
SJS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
its PRON B-O
severe ADJ B-O
variant NOUN B-O
, PUNCT B-O
toxic ADJ B-LF
epidermal ADJ I-LF
necrolysis NOUN I-LF
( PUNCT B-O
TEN PROPN B-AC
) PUNCT B-O
, PUNCT B-O
are AUX B-O
drug NOUN B-O
- PUNCT B-O
induced VERB B-O
acute ADJ B-O
inflammatory ADJ B-O
vesiculobullous ADJ B-O
reactions NOUN B-O
of ADP B-O
the DET B-O
skin NOUN B-O
and CCONJ B-O
mucous ADJ B-O
membranes NOUN B-O
, PUNCT B-O
including VERB B-O
the DET B-O
ocular ADJ B-O
surface NOUN B-O
. PUNCT B-O

Previous ADJ B-O
analysis NOUN B-O
has AUX B-O
shown VERB B-O
that PRON B-O
neutrophils NOUN B-O
from ADP B-O
healthy ADJ B-LF
controls NOUN I-LF
( PUNCT B-O
HCs PROPN B-AC
) PUNCT B-O
are AUX B-O
capable ADJ B-O
of ADP B-O
efficiently ADV B-O
binding VERB B-O
Gal-9 PROPN B-AC
; PUNCT B-O
however ADV B-O
, PUNCT B-O
the DET B-O
receptor NOUN B-O
that PRON B-O
facilitate VERB B-O
this DET B-O
binding VERB B-O
activity NOUN B-O
was AUX B-O
not PART B-O
identified VERB B-O
[ PUNCT B-O
50 NUM B-O
] PUNCT B-O
. PUNCT B-O

Identification NOUN B-O
of ADP B-O
new ADJ B-O
genes NOUN B-O
from ADP B-O
the DET B-O
sequence NOUN B-O
data NOUN B-O
and CCONJ B-O
placement NOUN B-O
of ADP B-O
all DET B-O
genes NOUN B-O
, PUNCT B-O
along ADP B-O
with ADP B-O
genetic ADJ B-O
markers NOUN B-O
, PUNCT B-O
on ADP B-O
a DET B-O
physical ADJ B-O
assembly NOUN B-O
has AUX B-O
greatly ADV B-O
aided VERB B-O
in ADP B-O
the DET B-O
search NOUN B-O
for ADP B-O
phenotypically ADV B-O
important ADJ B-O
genes NOUN B-O
in ADP B-O
both CCONJ B-O
quantitative ADJ B-LF
trait NOUN I-LF
loci NOUN I-LF
( PUNCT B-O
QTL PROPN B-AC
) PUNCT B-O
and CCONJ B-O
mutagenesis NOUN B-O
- PUNCT B-O
based VERB B-O
mapping NOUN B-O
. PUNCT B-O

Individuals NOUN B-O
can AUX B-O
be AUX B-O
diagnosed VERB B-O
when SCONJ B-O
they PRON B-O
develop VERB B-O
symptoms NOUN B-O
and CCONJ B-O
present VERB B-O
at ADP B-O
a DET B-O
clinic NOUN B-O
, PUNCT B-O
or CCONJ B-O
when SCONJ B-O
they PRON B-O
are AUX B-O
referred VERB B-O
from ADP B-O
an DET B-O
antenatal ADJ B-LF
clinic NOUN I-LF
( PUNCT B-O
ANC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
when SCONJ B-O
they PRON B-O
voluntarily ADV B-O
get AUX B-O
tested VERB B-O
for ADP B-O
HIV PROPN B-O
( PUNCT B-O
voluntary ADJ B-LF
counselling NOUN I-LF
and CCONJ I-LF
testing NOUN I-LF
, PUNCT B-O
VCT PROPN B-AC
) PUNCT B-O
. PUNCT B-O

For ADP B-O
simplicity NOUN B-O
, PUNCT B-O
we PRON B-O
investigated VERB B-O
circumstances NOUN B-O
that PRON B-O
range VERB B-O
from ADP B-O
the DET B-O
worst ADJ B-O
- PUNCT B-O
case NOUN B-O
to ADP B-O
the DET B-O
achievable ADJ B-O
best ADJ B-O
- PUNCT B-O
case NOUN B-O
scenario NOUN B-O
. PUNCT B-O

TBC PROPN B-AC
, PUNCT B-O
Tre2 PROPN B-LF
- PUNCT I-LF
Bub2 PROPN I-LF
- PUNCT I-LF
Cdc16 PROPN I-LF
. PUNCT B-O

* PUNCT B-O
* PUNCT B-O
* PUNCT B-O
p NOUN B-O
< SYM B-O
0.001 NUM B-O
LAD PROPN B-AC
, PUNCT B-O
left ADJ B-LF
atrial ADJ I-LF
diameter NOUN I-LF
; PUNCT B-O
LVDd PROPN B-AC
, PUNCT B-O
left ADJ B-LF
ventricular ADJ I-LF
end NOUN I-LF
- PUNCT I-LF
diastolic ADJ I-LF
diameter NOUN I-LF
; PUNCT B-O
LVDs PROPN B-AC
, PUNCT B-O
left ADJ B-LF
ventricular ADJ I-LF
end NOUN I-LF
- PUNCT I-LF
systolic ADJ I-LF
diameter NOUN I-LF
; PUNCT B-O
IVSth PROPN B-AC
, PUNCT B-O
intraventricular ADJ B-LF
septum NOUN I-LF
thickness NOUN I-LF
; PUNCT B-O
PWth PROPN B-AC
, PUNCT B-O
posterior ADJ B-LF
wall NOUN I-LF
thickness NOUN I-LF
; PUNCT B-O
LVEF PROPN B-AC
, PUNCT B-O
LV NOUN B-LF
ejection NOUN I-LF
LV PROPN B-AC
fraction NOUN I-LF
; PUNCT B-O
LVM PROPN B-AC
, PUNCT B-O
LV NOUN B-LF
mass NOUN I-LF
LV PROPN B-AC
; PUNCT B-O
LVMI PROPN B-AC
, PUNCT B-O
LV NOUN B-LF
mass NOUN I-LF
LV PROPN B-AC
index NOUN I-LF
; PUNCT B-O
E PROPN B-AC
/ SYM B-O
e NOUN B-O
’ PUNCT B-O
, PUNCT B-O
the DET B-O
ratio NOUN B-O
of ADP B-O
early ADJ B-LF
- PUNCT I-LF
diastolic ADJ I-LF
left ADJ I-LF
ventricular ADJ I-LF
inflow ADJ I-LF
velocity NOUN I-LF
( PUNCT B-O
E PROPN B-AC
) PUNCT B-O
to ADP B-O
early ADJ B-O
- PUNCT B-O
diastolic ADJ B-O
mitral ADJ B-O
annular ADJ B-O
velocity NOUN B-O
( PUNCT B-O
e′ NOUN B-O
): PUNCT B-O
LAVI PROPN B-AC
, PUNCT B-O
left ADJ B-LF
atrial ADJ I-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
other ADJ B-O
abbreviations NOUN B-O
as ADP B-O
in ADP B-O
Table NOUN B-O
2 NUM B-O
. PUNCT B-O

LDL PROPN B-AC
, PUNCT B-O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Confocal ADJ B-O
fluorescence NOUN B-O
image NOUN B-O
of ADP B-O
miniSOG PROPN B-AC
targeted VERB B-O
to ADP B-O
the DET B-O
mitochondria NOUN B-O
in ADP B-O
body NOUN B-O
wall NOUN B-O
muscles NOUN B-O
of ADP B-O
C. NOUN B-O
elegans NOUN B-O
. PUNCT B-O

( PUNCT B-O
B X B-O
– PUNCT B-O
C NOUN B-O
) PUNCT B-O
Thin ADJ B-O
section NOUN B-O
EM PROPN B-AC
images NOUN B-O
of ADP B-O
a DET B-O
portion NOUN B-O
of ADP B-O
C. NOUN B-O
elegans NOUN B-O
showing VERB B-O
a DET B-O
subset NOUN B-O
of ADP B-O
labeled VERB B-O
mitochondria NOUN B-O
in ADP B-O
the DET B-O
body NOUN B-O
wall NOUN B-O
muscle NOUN B-O
( PUNCT B-O
arrow NOUN B-O
) PUNCT B-O
and CCONJ B-O
adjacent ADJ B-O
unlabeled VERB B-O
mitochondria NOUN B-O
in ADP B-O
a DET B-O
different ADJ B-O
cell NOUN B-O
type NOUN B-O
( PUNCT B-O
arrowheads NOUN B-O
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
D X B-O
– PUNCT B-O
E X B-O
) PUNCT B-O
Ultrastructural ADJ B-O
localization NOUN B-O
of ADP B-O
miniSOG PROPN B-AC
- PUNCT B-O
labeled VERB B-O
synaptic ADJ B-LF
cell NOUN I-LF
- PUNCT I-LF
adhesion NOUN I-LF
molecules NOUN I-LF
( PUNCT B-O
SynCAMs PROPN B-AC
) PUNCT B-O
in ADP B-O
cultured VERB B-O
cortical ADJ B-O
neurons NOUN B-O
. PUNCT B-O

( PUNCT B-O
D X B-O
) PUNCT B-O
SynCAM1 PROPN B-O
fusion NOUN B-O
reveals VERB B-O
uniform ADJ B-O
membrane NOUN B-O
labeling NOUN B-O
at ADP B-O
the DET B-O
presynaptic ADJ B-O
apposition NOUN B-O
( PUNCT B-O
arrow NOUN B-O
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
E X B-O
) PUNCT B-O
SynCAM2 PROPN B-O
fusion NOUN B-O
shows VERB B-O
postsynaptic ADJ B-O
membrane NOUN B-O
labeling NOUN B-O
( PUNCT B-O
pointed VERB B-O
by ADP B-O
arrow NOUN B-O
) PUNCT B-O
. PUNCT B-O

Att PROPN B-O
, PUNCT B-O
Attacin PROPN B-O
A PROPN B-O
; PUNCT B-O
Dpt PROPN B-O
, PUNCT B-O
Diptericin PROPN B-O
; PUNCT B-O
Drs NOUN B-O
, PUNCT B-O
Drosomycin PROPN B-O
; PUNCT B-O
IMD PROPN B-O
/ SYM B-O
NFkB PROPN B-AC
, PUNCT B-O
immune ADJ B-O
deficiency NOUN B-O
/ SYM B-O
nuclear ADJ B-LF
factor NOUN I-LF
kappa NOUN I-LF
B PROPN I-LF
; PUNCT B-O
qRT PROPN B-AC
, PUNCT B-O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
PCR NOUN I-LF
; PUNCT B-O
-PCRRNAi PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT B-O

We PRON B-O
sought VERB B-O
to ADP B-O
develop VERB B-O
and CCONJ B-O
validate VERB B-O
an DET B-O
outcomes NOUN B-O
model NOUN B-O
for ADP B-O
the DET B-O
development NOUN B-O
of ADP B-O
diabetes NOUN B-O
and CCONJ B-O
related ADJ B-O
complications NOUN B-O
derived VERB B-O
from ADP B-O
Chinese ADJ B-O
( PUNCT B-O
East ADJ B-O
Asian ADJ B-O
) PUNCT B-O
populations NOUN B-O
and CCONJ B-O
compare VERB B-O
this DET B-O
new ADJ B-O
Chinese ADJ B-LF
Hong PROPN I-LF
Kong PROPN I-LF
Integrated PROPN I-LF
Modeling PROPN I-LF
and CCONJ I-LF
Evaluation PROPN I-LF
( PUNCT B-O
CHIME PROPN B-AC
) PUNCT B-O
model NOUN B-O
to ADP B-O
the DET B-O
existing VERB B-O
UKPDS PROPN B-AC
and CCONJ B-O
-OM2RECODe PROPN B-AC
models NOUN B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Immunoblot NOUN B-O
analysis NOUN B-O
of ADP B-O
acetylation NOUN B-O
levels NOUN B-O
of ADP B-O
7 NUM B-O
lysine NOUN B-O
residues NOUN B-O
on ADP B-O
histone NOUN B-O
H3 NOUN B-O
protein NOUN B-O
in ADP B-O
the DET B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
( PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
strain NOUN B-O
and CCONJ B-O
the DET B-O
mutants NOUN B-O
ΔHdac1 NOUN B-O
and CCONJ B-O
ΔHat1 NOUN B-O
. PUNCT B-O

Different ADJ B-O
subtypes NOUN B-O
of ADP B-O
T NOUN B-LF
helper NOUN I-LF
( PUNCT B-O
Th PROPN B-AC
) PUNCT B-O
cells NOUN B-O
are AUX B-O
activated VERB B-O
in ADP B-O
different ADJ B-O
types NOUN B-O
of ADP B-O
chronic ADJ B-O
intestinal ADJ B-O
inflammation NOUN B-O
. PUNCT B-O

For ADP B-O
encoding NOUN B-O
and CCONJ B-O
consolidation NOUN B-O
, PUNCT B-O
we PRON B-O
compared VERB B-O
30 NUM B-O
min NOUN B-O
and CCONJ B-O
5 NUM B-O
h NOUN B-O
after ADP B-O
the DET B-O
watermaze NOUN B-LF
encoding NOUN B-O
session NOUN B-O
animals NOUN B-O
that PRON B-O
experienced VERB B-O
the DET B-O
watermaze NOUN B-LF
( PUNCT B-O
WM PROPN B-AC
) PUNCT B-O
directly ADV B-O
with ADP B-O
animals NOUN B-O
that PRON B-O
had AUX B-O
not PART B-O
experienced VERB B-O
the DET B-O
watermaze NOUN B-LF
( PUNCT B-O
NoWM PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Thus ADV B-O
, PUNCT B-O
positive ADJ B-O
values NOUN B-O
on ADP B-O
the DET B-O
y NOUN B-O
- NOUN B-O
axis NOUN B-O
show VERB B-O
that PRON B-O
animals NOUN B-O
consolidating VERB B-O
a DET B-O
memory NOUN B-O
( PUNCT B-O
WM PROPN B-AC
) PUNCT B-O
show VERB B-O
higher ADJ B-O
gene NOUN B-O
expression NOUN B-O
than ADP B-O
animals NOUN B-O
that PRON B-O
are AUX B-O
not PART B-O
consolidating VERB B-O
a DET B-O
memory NOUN B-O
( PUNCT B-O
NoWM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
independent ADJ B-O
of ADP B-O
what PRON B-O
they PRON B-O
are AUX B-O
doing VERB B-O
at ADP B-O
the DET B-O
moment NOUN B-O
( PUNCT B-O
sleep NOUN B-O
/ SYM B-O
N+SD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Additionally ADV B-O
, PUNCT B-O
to PART B-O
investigate VERB B-O
the DET B-O
differences NOUN B-O
between ADP B-O
sleep NOUN B-O
and CCONJ B-O
N PROPN B-AC
animals NOUN B-O
at ADP B-O
retrieval NOUN B-O
, PUNCT B-O
we PRON B-O
calculated VERB B-O
percentage NOUN B-O
change NOUN B-O
( PUNCT B-O
sleep NOUN B-O
> SYM B-O
+SDN PROPN B-AC
) PUNCT B-O
on ADP B-O
each DET B-O
plate NOUN B-O
and CCONJ B-O
then ADV B-O
averaged VERB B-O
the DET B-O
data NOUN B-O
( PUNCT B-O
see VERB B-O
S7 PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

AOR PROPN B-AC
= PUNCT B-O
Adjusted ADJ B-O
Adds NOUN B-O
Ratio NOUN B-O
, PUNCT B-O
COR PROPN B-AC
= PUNCT B-O
Crude NOUN B-LF
Odds NOUN I-LF
Ratio NOUN I-LF
. PUNCT B-O