diff --git "a/train.conll" "b/train.conll"
new file mode 100644--- /dev/null
+++ "b/train.conll"
@@ -0,0 +1,41071 @@
+For ADP B-O
+this DET B-O
+purpose NOUN B-O
+the DET B-O
+Gothenburg PROPN B-LF
+Young PROPN I-LF
+Persons PROPN I-LF
+Empowerment PROPN I-LF
+Scale PROPN I-LF
+( PUNCT B-O
+GYPES PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+developed VERB B-O
+. PUNCT B-O
+
+The DET B-O
+following ADJ B-O
+physiological ADJ B-O
+traits NOUN B-O
+were AUX B-O
+measured VERB B-O
+: PUNCT B-O
+stomatal ADJ B-LF
+conductance NOUN I-LF
+( PUNCT B-O
+gs PROPN B-AC
+, PUNCT B-O
+mol NOUN B-O
+H2O NOUN B-O
+m-2 NOUN B-O
+s-1 NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+transpiration NOUN B-LF
+rate NOUN I-LF
+( PUNCT B-O
+E PROPN B-AC
+, PUNCT B-O
+mmol NOUN B-O
+H2O NOUN B-O
+m-2 NOUN B-O
+s-1 NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+net ADJ B-LF
+photosynthetic ADJ I-LF
+rate NOUN I-LF
+( PUNCT B-O
+PN PROPN B-AC
+, PUNCT B-O
+μmol NOUN B-O
+m-2 NOUN B-O
+s-1 NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+intercellular ADJ B-LF
+CO2 NOUN I-LF
+concentration NOUN I-LF
+CO2 PROPN B-AC
+( PUNCT B-O
+Ci PROPN B-AC
+, PUNCT B-O
+μmol NOUN B-O
+m-2 NOUN B-O
+s-1 NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Minor ADJ B-O
+H PROPN B-AC
+antigen NOUN B-O
+alloimmune ADJ B-O
+responses NOUN B-O
+readily ADV B-O
+occur VERB B-O
+in ADP B-O
+the DET B-O
+setting NOUN B-O
+of ADP B-O
+human ADJ B-LF
+leukocyte NOUN I-LF
+antigen NOUN I-LF
+( PUNCT B-O
+HLA)–matched PROPN B-AC
+allogeneic ADJ B-O
+solid ADJ B-O
+organ NOUN B-O
+and CCONJ B-O
+stem NOUN B-LF
+cell NOUN I-LF
+transplantation NOUN I-LF
+( PUNCT B-O
+SCT PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+3,4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+EPI PROPN B-AC
+= PUNCT B-O
+Echo NOUN B-LF
+planar NOUN I-LF
+imaging NOUN I-LF
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+eNOS PROPN B-AC
+- PUNCT B-O
+derived VERB B-O
+NO PROPN B-AC
+S NOUN B-O
+- PUNCT B-O
+nitrosylated VERB B-O
+β PUNCT B-O
+- PUNCT B-O
+actin NOUN B-O
+on ADP B-O
+Cys374 PROPN B-O
+and CCONJ B-O
+impaired VERB B-O
+actin NOUN B-O
+binding VERB B-O
+to ADP B-O
+profilin-1 NOUN B-LF
+( PUNCT B-O
+PFN1 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+as SCONJ B-O
+confirmed VERB B-O
+with ADP B-O
+the DET B-O
+transnitrosylating NOUN B-O
+agent NOUN B-O
+S NOUN B-LF
+- PUNCT I-LF
+nitroso NOUN I-LF
+- PUNCT I-LF
+L NOUN I-LF
+- PUNCT I-LF
+cysteine NOUN I-LF
+( PUNCT B-O
+Cys-NO PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The PROPN B-AC
+importance NOUN B-O
+of ADP B-O
+NO PROPN B-AC
+and CCONJ B-O
+the DET B-O
+formation NOUN B-O
+of ADP B-O
+PFN1 PROPN B-AC
+- PUNCT B-O
+actin NOUN B-O
+complexes NOUN B-O
+on ADP B-O
+the DET B-O
+regulation NOUN B-O
+of ADP B-O
+PKC PROPN B-AC
+was AUX B-O
+corroborated VERB B-O
+by ADP B-O
+overexpression NOUN B-O
+of ADP B-O
+-θPFN1- PROPN B-AC
+and CCONJ B-O
+actin NOUN B-O
+- PUNCT B-O
+binding VERB B-O
+defective ADJ B-O
+mutants NOUN B-O
+of ADP B-O
+β PUNCT B-O
+- PUNCT B-O
+actin NOUN B-O
+( PUNCT B-O
+C374S PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+PFN1 PROPN B-AC
+( PUNCT B-O
+H119E PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+respectively ADV B-O
+, PUNCT B-O
+which PRON B-O
+reduced VERB B-O
+the DET B-O
+coalescence NOUN B-O
+of ADP B-O
+PKC PROPN B-AC
+at ADP B-O
+the DET B-O
+-θc-SMAC PROPN B-AC
+. PUNCT B-O
+
+These DET B-O
+findings NOUN B-O
+unveil VERB B-O
+a DET B-O
+novel ADJ B-O
+NO PROPN B-AC
+- PUNCT B-O
+dependent ADJ B-O
+mechanism NOUN B-O
+by ADP B-O
+which PRON B-O
+the DET B-O
+actin NOUN B-O
+cytoskeleton NOUN B-O
+controls VERB B-O
+the DET B-O
+organization NOUN B-O
+and CCONJ B-O
+activation NOUN B-O
+of ADP B-O
+signaling NOUN B-O
+microclusters NOUN B-O
+at ADP B-O
+the DET B-O
+IS PROPN B-AC
+. PUNCT B-O
+
+Both DET B-O
+Mekk3 PROPN B-O
+cKO PROPN B-AC
+and CCONJ B-O
+their PRON B-O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+( PUNCT B-O
+WT PROPN B-AC
+) PUNCT B-O
+littermates NOUN B-O
+were AUX B-O
+labeled VERB B-O
+at ADP B-O
+E16.5 NUM B-O
+with ADP B-O
+5 NUM B-LF
+- PUNCT I-LF
+bromo-2’-deoxyuridine NOUN I-LF
+( PUNCT B-O
+BrdU PROPN B-AC
+) PUNCT B-O
+to PART B-O
+track VERB B-O
+cells NOUN B-O
+undergoing VERB B-O
+DNA NOUN B-O
+synthesis NOUN B-O
+. PUNCT B-O
+
+Recent ADJ B-O
+work NOUN B-O
+by ADP B-O
+us PRON B-O
+and CCONJ B-O
+others NOUN B-O
+suggests VERB B-O
+that SCONJ B-O
+the DET B-O
+host NOUN B-O
+’s PART B-O
+heat NOUN B-LF
+shock NOUN I-LF
+protein NOUN I-LF
+90 NUM I-LF
+( PUNCT B-O
+Hsp90 PROPN B-AC
+) PUNCT B-O
+chaperone NOUN B-O
+can AUX B-O
+modulate VERB B-O
+the DET B-O
+evolutionary ADJ B-O
+paths NOUN B-O
+traversed VERB B-O
+by ADP B-O
+viruses NOUN B-O
+[ PUNCT B-O
+18 NUM B-O
+, PUNCT B-O
+19 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+performed VERB B-O
+a DET B-O
+linear ADJ B-O
+regression NOUN B-O
+model NOUN B-O
+of ADP B-O
+the DET B-O
+effect NOUN B-O
+of ADP B-O
+PCL PROPN B-AC
+on ADP B-O
+Dizziness PROPN B-LF
+Handicap PROPN I-LF
+Inventory PROPN I-LF
+( PUNCT B-O
+DHI PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+DHI PROPN B-AC
+was AUX B-O
+significantly ADV B-O
+correlated VERB B-O
+to ADP B-O
+PCL PROPN B-AC
+scores NOUN B-O
+, PUNCT B-O
+suggesting VERB B-O
+that SCONJ B-O
+Veterans NOUN B-O
+with ADP B-O
+more ADJ B-O
+severe ADJ B-O
+PTSD PROPN B-AC
+symptoms NOUN B-O
+also ADV B-O
+had VERB B-O
+more ADJ B-O
+dizziness NOUN B-O
+handicap NOUN B-O
+as SCONJ B-O
+illustrated VERB B-O
+in ADP B-O
+Fig NUM B-O
+2 NUM B-O
+( PUNCT B-O
+r2 NOUN B-O
+= SYM B-O
+0.28 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+< SYM B-O
+0.0001 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Correlation NOUN B-O
+of ADP B-O
+( PUNCT B-O
+a X B-O
+) PUNCT B-O
+rate NOUN B-O
+of ADP B-O
+seed NOUN B-O
+mass NOUN B-O
+evolution NOUN B-O
+and CCONJ B-O
+( PUNCT B-O
+b X B-O
+) PUNCT B-O
+seed NOUN B-O
+mass NOUN B-O
+with ADP B-O
+speciation NOUN B-O
+rate NOUN B-O
+( PUNCT B-O
+λ PUNCT B-O
+) PUNCT B-O
+estimated VERB B-O
+by ADP B-O
+using VERB B-O
+R PROPN B-LF
+: PUNCT I-LF
+Phylogenetic PROPN I-LF
+ANalyses PROPN I-LF
+of ADP I-LF
+DiversificAtion PROPN I-LF
+( PUNCT B-O
+RPANDA PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+clade NOUN B-O
+- PUNCT B-O
+based VERB B-O
+analysis NOUN B-O
+. PUNCT B-O
+
+Typically ADV B-O
+, PUNCT B-O
+at ADP B-O
+low ADJ B-O
+inspiratory ADJ B-LF
+positive ADJ I-LF
+airway NOUN I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+IPAP PROPN B-AC
+) PUNCT B-O
+values NOUN B-O
+, PUNCT B-O
+short ADJ B-O
+PLBD PROPN B-AC
+and CCONJ B-O
+low ADJ B-O
+PLBP PROPN B-AC
+are AUX B-O
+set VERB B-O
+, PUNCT B-O
+at ADP B-O
+higher ADJ B-O
+IPAP PROPN B-AC
+values NOUN B-O
+, PUNCT B-O
+longer ADJ B-O
+PLBD PROPN B-AC
+and CCONJ B-O
+higher ADJ B-O
+PLBP PROPN B-AC
+are AUX B-O
+set VERB B-O
+. PUNCT B-O
+
+When SCONJ B-O
+considering VERB B-O
+the DET B-O
+appropriateness NOUN B-O
+of ADP B-O
+introducing VERB B-O
+an DET B-O
+ACP PROPN B-AC
+protocol NOUN B-O
+at ADP B-O
+KCMC PROPN B-AC
+, PUNCT B-O
+it PRON B-O
+was AUX B-O
+evident ADJ B-O
+that SCONJ B-O
+there PRON B-O
+was AUX B-O
+a DET B-O
+literature NOUN B-O
+deficit NOUN B-O
+on ADP B-O
+the DET B-O
+cultural ADJ B-O
+views NOUN B-O
+of ADP B-O
+quality NOUN B-LF
+of ADP I-LF
+death NOUN I-LF
+( PUNCT B-O
+QoD PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+Tanzania PROPN B-O
+but CCONJ B-O
+two NUM B-O
+previous ADJ B-O
+studies NOUN B-O
+from ADP B-O
+northern ADJ B-O
+Tanzania PROPN B-O
+had AUX B-O
+indicated VERB B-O
+that SCONJ B-O
+QoD PROPN B-AC
+was AUX B-O
+an DET B-O
+existing VERB B-O
+concept NOUN B-O
+in ADP B-O
+northern ADJ B-O
+Tanzania PROPN B-O
+. PUNCT B-O
+
+Positive ADJ B-O
+cells NOUN B-O
+from ADP B-O
+each DET B-O
+specimen NOUN B-O
+were AUX B-O
+counted VERB B-O
+from ADP B-O
+a DET B-O
+minimum NOUN B-O
+of ADP B-O
+four NUM B-O
+randomly ADV B-O
+selected VERB B-O
+fields NOUN B-O
+per ADP B-O
+high ADJ B-LF
+power NOUN I-LF
+field NOUN I-LF
+( PUNCT B-O
+HPF PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+compared VERB B-O
+with ADP B-O
+the DET B-O
+control NOUN B-O
+by ADP B-O
+calculating VERB B-O
+the DET B-O
+average ADJ B-O
+number NOUN B-O
+of ADP B-O
+cells NOUN B-O
+. PUNCT B-O
+
+FSC PROPN B-O
+, PUNCT B-O
+Fourier PROPN B-O
+Shell PROPN B-O
+Correlation PROPN B-O
+; PUNCT B-O
+MrNV PROPN B-AC
+, PUNCT B-O
+M. PROPN B-O
+rosenbergii PROPN B-O
+nodavirus NOUN B-O
+; PUNCT B-O
+3D PROPN B-AC
+, PUNCT B-O
+three NUM B-LF
+- PUNCT I-LF
+dimensional ADJ I-LF
+. PUNCT B-O
+
+In ADP B-O
+rodent ADJ B-O
+taste NOUN B-O
+cells NOUN B-O
+, PUNCT B-O
+expression NOUN B-O
+of ADP B-O
+insulin NOUN B-O
+and CCONJ B-O
+the DET B-O
+insulin NOUN B-LF
+receptor NOUN I-LF
+subunit NOUN I-LF
+α PUNCT I-LF
+( PUNCT B-O
+IRα PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+been AUX B-O
+proposed VERB B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+test VERB B-O
+this PRON B-O
+, PUNCT B-O
+we PRON B-O
+exposed VERB B-O
+the DET B-O
+mouse NOUN B-O
+intestine NOUN B-O
+to ADP B-O
+two NUM B-O
+conditions NOUN B-O
+: PUNCT B-O
+1 X B-O
+) PUNCT B-O
+30 NUM B-O
+min NOUN B-O
+of ADP B-O
+ischemia NOUN B-O
+followed VERB B-O
+by ADP B-O
+30 NUM B-O
+min NOUN B-O
+of ADP B-O
+reperfusion NOUN B-O
+stress NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+2 X B-O
+) PUNCT B-O
+ischemia NOUN B-LF
+/ SYM I-LF
+reperfusion NOUN I-LF
+( PUNCT B-O
+I/R PROPN B-AC
+) PUNCT B-O
+stress NOUN B-O
+coupled VERB B-O
+with ADP B-O
+luminal ADJ B-O
+inoculation NOUN B-O
+with ADP B-O
+P. NOUN B-O
+aeruginosa NOUN B-O
+( PUNCT B-O
+I PROPN B-AC
++ CCONJ B-O
+Pa PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+localization NOUN B-O
+of ADP B-O
+motility NOUN B-O
+complexes NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+thereby ADV B-O
+the DET B-O
+direction NOUN B-O
+of ADP B-O
+movement NOUN B-O
+, PUNCT B-O
+is AUX B-O
+determined VERB B-O
+by ADP B-O
+an DET B-O
+oscillatory ADJ B-O
+system NOUN B-O
+, PUNCT B-O
+which PRON B-O
+includes VERB B-O
+Mutual PROPN B-LF
+gliding NOUN I-LF
+motility NOUN I-LF
+A NOUN I-LF
+( PUNCT B-O
+MglA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+small ADJ B-O
+Ras PROPN B-O
+- PUNCT B-O
+like ADJ B-O
+GTPase NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+Mutual PROPN B-LF
+gliding NOUN I-LF
+motility NOUN I-LF
+B NOUN I-LF
+( PUNCT B-O
+MglB PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+its PRON B-O
+GTPase NOUN B-LF
+activating VERB I-LF
+protein NOUN I-LF
+( PUNCT B-O
+GAP PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+major ADJ B-O
+components NOUN B-O
+[ X B-O
+1,4,5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Using VERB B-O
+chemical NOUN B-O
+cross NOUN B-O
+- PUNCT B-O
+linking NOUN B-O
+/ SYM B-O
+MS PROPN B-AC
+, PUNCT B-O
+we PRON B-O
+had AUX B-O
+been AUX B-O
+able ADJ B-O
+to PART B-O
+monitor VERB B-O
+conformational ADJ B-O
+changes NOUN B-O
+in ADP B-O
+the DET B-O
+ligand NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+domain NOUN I-LF
+( PUNCT B-O
+LBD PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+PPAR PROPN B-AC
+- PUNCT B-O
+α PUNCT B-O
+upon SCONJ B-O
+ligand NOUN B-O
+binding.[8 NOUN B-O
+] PUNCT B-O
+Inbred ADJ B-O
+line NOUN B-O
+L8 PROPN B-O
+was AUX B-O
+about ADV B-O
+the DET B-O
+most ADV B-O
+distant ADJ B-O
+line NOUN B-O
+to ADP B-O
+the DET B-O
+three NUM B-O
+testers NOUN B-O
+based VERB B-O
+on ADP B-O
+both DET B-O
+GDs PROPN B-AC
+. PUNCT B-O
+
+As SCONJ B-O
+shown VERB B-O
+in ADP B-O
+Fig NOUN B-O
+1 NUM B-O
+, PUNCT B-O
+the DET B-O
+genetic ADJ B-LF
+distance NOUN I-LF
+estimates NOUN B-O
+between ADP B-O
+the DET B-O
+Striga PROPN B-O
+resistant ADJ B-O
+lines NOUN B-O
+and CCONJ B-O
+the DET B-O
+resistant ADJ B-O
+tester NOUN B-O
+were AUX B-O
+broader ADJ B-O
+in ADP B-O
+the DET B-O
+range NOUN B-O
+of ADP B-O
+GD PROPN B-AC
+values NOUN B-O
+than ADP B-O
+those PRON B-O
+between ADP B-O
+the DET B-O
+Striga PROPN B-O
+- PUNCT B-O
+resistant ADJ B-O
+and CCONJ B-O
+susceptible ADJ B-O
+tester NOUN B-O
+, PUNCT B-O
+indicating VERB B-O
+the DET B-O
+resistant ADJ B-O
+tester NOUN B-O
+was AUX B-O
+considered VERB B-O
+as ADP B-O
+a DET B-O
+suitable ADJ B-O
+tester NOUN B-O
+. PUNCT B-O
+
+Cardiac ADJ B-O
+inflammation NOUN B-O
+induced VERB B-O
+by ADP B-O
+B. PROPN B-O
+burgdorferi PROPN B-O
+is AUX B-O
+dependent ADJ B-O
+on ADP B-O
+the DET B-O
+interaction NOUN B-O
+of ADP B-O
+the DET B-O
+spirochete NOUN B-O
+with ADP B-O
+macrophages NOUN B-O
+and CCONJ B-O
+other ADJ B-O
+cell NOUN B-O
+types NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+invariant ADJ B-LF
+NKT NOUN I-LF
+( PUNCT B-O
+iNKT PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+T NOUN B-O
+cells NOUN B-O
+[ PUNCT B-O
+35 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+are AUX B-O
+expressed VERB B-O
+as ADP B-O
+mean NOUN B-O
+± ADP B-O
+SEM PROPN B-AC
+, PUNCT B-O
+n NOUN B-O
+= SYM B-O
+3 NUM B-O
+from ADP B-O
+at ADV B-O
+least ADV B-O
+three NUM B-O
+independent ADJ B-O
+experiments NOUN B-O
+; PUNCT B-O
+nd PROPN B-AC
+: PUNCT B-O
+not PART B-LF
+detected VERB I-LF
+or CCONJ B-O
+below ADP B-O
+the DET B-O
+limit NOUN B-O
+of ADP B-O
+quantitation NOUN B-O
+. PUNCT B-O
+
+BMI NOUN B-O
+: PUNCT B-O
+body NOUN B-O
+mass NOUN B-O
+index NOUN B-O
+; PUNCT B-O
+CE PROPN B-AC
+: PUNCT B-O
+cholesteryl ADJ B-O
+ester NOUN B-O
+; PUNCT B-O
+ELF PROPN B-AC
+: PUNCT B-O
+epithelial ADJ B-LF
+lining NOUN I-LF
+fluid NOUN I-LF
+; PUNCT B-O
+FEV1 PROPN B-AC
+: PUNCT B-O
+forced VERB B-LF
+expiratory ADJ I-LF
+volume NOUN I-LF
+in ADP I-LF
+1 NUM I-LF
+second NOUN I-LF
+; PUNCT B-O
+FVC PROPN B-AC
+: PUNCT B-O
+forced VERB B-LF
+vital ADJ I-LF
+capacity NOUN I-LF
+; PUNCT B-O
+IL PROPN B-O
+: PUNCT B-O
+Interleukin NOUN B-O
+; PUNCT B-O
+LABA PROPN B-O
+: PUNCT B-O
+long VERB B-O
+acting VERB B-O
+beta NOUN B-O
+agonists NOUN B-O
+; PUNCT B-O
+LAMA PROPN B-O
+: PUNCT B-O
+long VERB B-O
+acting VERB B-O
+muscarinic ADJ B-O
+antagonists NOUN B-O
+; PUNCT B-O
+MCP-1 NOUN B-O
+: PUNCT B-O
+macrophage NOUN B-O
+chemotactic ADJ B-O
+protein-1 NOUN B-O
+; PUNCT B-O
+TG PROPN B-AC
+: PUNCT B-O
+triglyceride NOUN B-O
+. PUNCT B-O
+
+DEFF PROPN B-AC
+: PUNCT B-O
+Design NOUN B-LF
+effect NOUN I-LF
+; PUNCT B-O
+ICC PROPN B-AC
+: PUNCT B-O
+Intracluster ADJ B-LF
+correlation NOUN I-LF
+coefficient NOUN I-LF
+; PUNCT B-O
+SD PROPN B-AC
+: PUNCT B-O
+Standard ADJ B-LF
+deviation NOUN I-LF
+; PUNCT B-O
+IQR PROPN B-AC
+: PUNCT B-O
+Interquartile ADJ B-LF
+range NOUN I-LF
+. PUNCT B-O
+
+The DET B-O
+leading VERB B-O
+causes NOUN B-O
+of ADP B-O
+death NOUN B-O
+and CCONJ B-O
+morbidity NOUN B-O
+worldwide ADV B-O
+are AUX B-O
+noncommunicable ADJ B-LF
+diseases NOUN I-LF
+( PUNCT B-O
+NCDs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+chronic ADJ B-O
+respiratory ADJ B-O
+disease NOUN B-O
+, PUNCT B-O
+cancer NOUN B-O
+, PUNCT B-O
+diabetes NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+, PUNCT B-O
+in ADP B-O
+particular ADJ B-O
+, PUNCT B-O
+ischemic ADJ B-O
+heart NOUN B-O
+disease NOUN B-O
+and CCONJ B-O
+stroke NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+slope NOUN B-O
+of ADP B-O
+field NOUN B-LF
+excitatory ADJ I-LF
+postsynaptic ADJ I-LF
+potentials NOUN I-LF
+( PUNCT B-O
+fEPSPs PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+Fig NOUN B-O
+6B NUM B-O
+) PUNCT B-O
+was AUX B-O
+measured VERB B-O
+to PART B-O
+monitor VERB B-O
+synaptic ADJ B-O
+activation NOUN B-O
+of ADP B-O
+the DET B-O
+CA1 NOUN B-O
+pyramidal ADJ B-O
+neurons NOUN B-O
+. PUNCT B-O
+
+BAZ PROPN B-AC
+, PUNCT B-O
+BMI NOUN B-LF
+- PUNCT I-LF
+BMI PROPN B-AC
+for ADP I-LF
+- PUNCT I-LF
+age NOUN I-LF
+z- NOUN B-O
+score NOUN B-O
+; PUNCT B-O
+T PROPN B-AC
+, PUNCT B-O
+triene NOUN B-O
+- PUNCT B-O
+to ADP B-O
+- PUNCT B-O
+tetraene NOUN B-O
+These DET B-O
+supercomplexes NOUN B-O
+are AUX B-O
+associations NOUN B-O
+of ADP B-O
+oxidase NOUN B-O
+with ADP B-O
+either CCONJ B-O
+respiratory ADJ B-O
+complexIII PROPN B-AC
+and CCONJ B-O
+cytochrome NOUN B-LF
+c552 NOUN I-LF
+( PUNCT B-O
+Sc NOUN B-O
+: PUNCT B-O
+III4IV2 NUM B-O
+, PUNCT B-O
+Sb NOUN B-O
+: PUNCT B-O
+III4IV4 NUM B-O
+) PUNCT B-O
+or CCONJ B-O
+of ADP B-O
+complex PROPN B-AC
+, PUNCT B-O
+IIIcomplexI PROPN B-AC
+and CCONJ B-O
+cyt PROPN B-AC
+( PUNCT B-O
+Sa NOUN B-O
+: PUNCT B-O
+I1III4IV4 NOUN B-O
+; PUNCT B-O
+S1 NOUN B-O
+, PUNCT B-O
+S3 PROPN B-O
+and CCONJ B-O
+S4 PROPN B-O
+Figs NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+Ct PROPN B-AC
+, PUNCT B-O
+cycle NOUN B-LF
+threshold NOUN I-LF
+; PUNCT B-O
+n NOUN B-O
+/ SYM B-O
+a NOUN B-O
+, PUNCT B-O
+not PART B-O
+applicable ADJ B-O
+; PUNCT B-O
+N1 PROPN B-AC
+, PUNCT B-O
+SARS PROPN B-LF
+- PUNCT I-LF
+SARS PROPN B-AC
+CoV-2 NOUN I-LF
+nucleocapsid NOUN I-LF
+gene NOUN I-LF
+region NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+-CoV-2SARS PROPN B-AC
+, PUNCT B-O
+severe ADJ B-LF
+acute ADJ I-LF
+respiratory ADJ I-LF
+syndrome NOUN I-LF
+coronavirus NOUN I-LF
+2 NUM I-LF
+; PUNCT B-O
+Unk PROPN B-O
+, PUNCT B-O
+Unknown ADJ B-O
+To PART B-O
+further ADV B-O
+identify VERB B-O
+significant ADJ B-O
+correlations NOUN B-O
+between ADP B-O
+phenotypes NOUN B-O
+and CCONJ B-O
+GO PROPN B-AC
+concepts NOUN B-O
+, PUNCT B-O
+we PRON B-O
+used VERB B-O
+a DET B-O
+GO PROPN B-AC
+term NOUN B-O
+finder NOUN B-O
+software NOUN B-O
+[ X B-O
+49 X B-O
+] X B-O
+to ADP B-O
+correlate VERB B-O
+phenotypes NOUN B-O
+with ADP B-O
+GO PROPN B-AC
+using VERB B-O
+the DET B-O
+Pfam PROPN B-AC
+to ADP B-O
+GO PROPN B-AC
+mapping NOUN B-O
+data NOUN B-O
+from ADP B-O
+the DET B-O
+Gene PROPN B-LF
+Ontology PROPN I-LF
+Consortium PROPN B-O
+. PUNCT B-O
+
+Crude ADJ B-LF
+lipid NOUN I-LF
+extract NOUN I-LF
+( PUNCT B-O
+CLE PROPN B-AC
+in ADP B-O
+mg NOUN B-O
+) PUNCT B-O
+was AUX B-O
+estimated VERB B-O
+following VERB B-O
+Cointet PROPN B-O
+et PROPN B-O
+al PROPN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+2019 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+lipid NOUN B-O
+content NOUN B-O
+( PUNCT B-O
+LC NOUN B-O
+) PUNCT B-O
+was AUX B-O
+estimated VERB B-O
+in ADP B-O
+mg NOUN B-O
+. PUNCT B-O
+
+L-1 NOUN B-O
+. PUNCT B-O
+
+One NUM B-O
+day NOUN B-O
+after ADP B-O
+the DET B-O
+preparation NOUN B-O
+, PUNCT B-O
+slice NOUN B-O
+cultures NOUN B-O
+were AUX B-O
+transduced VERB B-O
+with ADP B-O
+adeno NOUN B-LF
+- NOUN I-LF
+associated VERB I-LF
+virus NOUN I-LF
+( PUNCT B-O
+AAV PROPN B-AC
+) PUNCT B-O
+serotype NOUN B-O
+9 NUM B-O
+particles NOUN B-O
+encoding VERB B-O
+CaMKII.iGluu NOUN B-O
+. PUNCT B-O
+
+WPRE NOUN B-O
+- NOUN B-O
+hGH NOUN B-O
+[ PUNCT B-O
+30 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Potato NOUN B-LF
+dextrose NOUN I-LF
+agar NOUN I-LF
+( PUNCT B-O
+PDA PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+potato NOUN B-LF
+dextrose NOUN I-LF
+broth NOUN I-LF
+( PUNCT B-O
+PDB PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+purchased VERB B-O
+from ADP B-O
+Difco PROPN B-O
+( PUNCT B-O
+BD PROPN B-O
+, PUNCT B-O
+USA PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Calcium NOUN B-LF
+carbonate NOUN I-LF
+( PUNCT B-O
+CaCO3 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+ethanol NOUN B-O
+were AUX B-O
+purchased VERB B-O
+from ADP B-O
+Systerm PROPN B-O
+( PUNCT B-O
+Selangor PROPN B-O
+, PUNCT B-O
+Malaysia PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rates NOUN I-LF
+( PUNCT B-O
+eGFRs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+calculated VERB B-O
+using VERB B-O
+the DET B-O
+four NUM B-O
+- PUNCT B-O
+variable NOUN B-O
+equation NOUN B-O
+derived VERB B-O
+from ADP B-O
+the DET B-O
+Modification PROPN B-LF
+of ADP I-LF
+Diet PROPN I-LF
+in ADP I-LF
+Renal PROPN I-LF
+Disease PROPN I-LF
+( PUNCT B-O
+MDRD PROPN B-AC
+) PUNCT B-O
+Study PROPN B-O
+. PUNCT B-O
+
+We PRON B-O
+used VERB B-O
+the DET B-O
+cross ADJ B-O
+- PUNCT B-O
+sectional ADJ B-O
+data NOUN B-O
+including VERB B-O
+6,160 NUM B-O
+oldest ADJ B-O
+old ADJ B-O
+( PUNCT B-O
+aged ADJ B-O
+80 NUM B-O
+years NOUN B-O
+old ADJ B-O
+or CCONJ B-O
+older ADJ B-O
+) PUNCT B-O
+from ADP B-O
+the DET B-O
+genetic ADJ B-O
+substudy NOUN B-O
+of ADP B-O
+the DET B-O
+Chinese PROPN B-LF
+Longitudinal PROPN I-LF
+Healthy PROPN I-LF
+Longevity PROPN I-LF
+Survey PROPN I-LF
+( PUNCT B-O
+CLHLS PROPN B-AC
+) PUNCT B-O
+which PRON B-O
+is AUX B-O
+a DET B-O
+national ADJ B-O
+wide ADJ B-O
+cohort NOUN B-O
+study NOUN B-O
+that PRON B-O
+began VERB B-O
+in ADP B-O
+1998 NUM B-O
+with ADP B-O
+follow VERB B-O
+- PUNCT B-O
+up ADP B-O
+surveys NOUN B-O
+every DET B-O
+2–3 NUM B-O
+years NOUN B-O
+. PUNCT B-O
+
+Surprisingly ADV B-O
+, PUNCT B-O
+although SCONJ B-O
+IL-22 PROPN B-AC
+activates VERB B-O
+signal NOUN B-LF
+transducer NOUN I-LF
+and CCONJ I-LF
+activator NOUN I-LF
+of ADP I-LF
+transcription NOUN I-LF
+3 NUM I-LF
+( PUNCT B-O
+STAT3 PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+APC PROPN B-O
+- PUNCT B-O
+mutant ADJ B-O
+cells NOUN B-O
+, PUNCT B-O
+STAT3 PROPN B-AC
+target NOUN B-O
+genes NOUN B-O
+were AUX B-O
+not PART B-O
+induced VERB B-O
+. PUNCT B-O
+
+Hh PROPN B-AC
+, PUNCT B-O
+hedgehog NOUN B-LF
+; PUNCT B-O
+NRF2 PROPN B-AC
+, PUNCT B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+- PUNCT I-LF
+erythroid NOUN I-LF
+2 NUM I-LF
+- PUNCT I-LF
+like NOUN I-LF
+2 NUM I-LF
+IMCD3 PROPN B-AC
+, PUNCT B-O
+inner ADJ B-LF
+medullary NOUN I-LF
+collecting VERB I-LF
+duct NOUN I-LF
+; PUNCT B-O
+Nb PROPN B-AC
+, PUNCT B-O
+nanobody NOUN B-LF
+; PUNCT B-O
+SMO PROPN B-O
+, PUNCT B-O
+Smoothened VERB B-O
+. PUNCT B-O
+
+Specifically ADV B-O
+, PUNCT B-O
+the DET B-O
+non ADJ B-O
+- ADJ B-O
+HCC PROPN B-AC
+participants NOUN B-O
+included VERB B-O
+123 NUM B-O
+with ADP B-O
+gastrointestinal ADJ B-O
+tumour NOUN B-O
+( PUNCT B-O
+GIT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+73 NUM B-O
+with ADP B-O
+benign ADJ B-O
+liver NOUN B-O
+tumour NOUN B-O
+( PUNCT B-O
+BLT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+453 NUM B-O
+with ADP B-O
+liver NOUN B-O
+cirrhosis NOUN B-O
+, PUNCT B-O
+27 NUM B-O
+with ADP B-O
+chronic ADJ B-LF
+hepatitis NOUN I-LF
+C NOUN I-LF
+( PUNCT B-O
+CHC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+86 NUM B-O
+with ADP B-O
+chronic ADJ B-LF
+hepatitis NOUN I-LF
+B NOUN I-LF
+( PUNCT B-O
+CHB PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+50 NUM B-O
+with ADP B-O
+benign ADJ B-LF
+gastrointestinal ADJ I-LF
+disease NOUN I-LF
+( PUNCT B-O
+BGID PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+295 NUM B-O
+healthy ADJ B-O
+people NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+generate VERB B-O
+null ADJ B-O
+alleles NOUN B-O
+, PUNCT B-O
+we PRON B-O
+sought VERB B-O
+to PART B-O
+create VERB B-O
+mutants NOUN B-O
+with ADP B-O
+large ADJ B-O
+fragment NOUN B-O
+deletions NOUN B-O
+by ADP B-O
+designing VERB B-O
+2 NUM B-O
+single ADJ B-LF
+guide NOUN I-LF
+RNAs NOUN I-LF
+( PUNCT B-O
+sgRNAs PROPN B-AC
+) PUNCT B-O
+within ADP B-O
+or CCONJ B-O
+flanking VERB B-O
+the DET B-O
+stem NOUN B-O
+- PUNCT B-O
+loop NOUN B-O
+region NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Using VERB B-O
+PCR NOUN B-O
+genotyping NOUN B-O
+, PUNCT B-O
+we PRON B-O
+successfully ADV B-O
+identified VERB B-O
+plants NOUN B-O
+carrying VERB B-O
+mutations NOUN B-O
+in ADP B-O
+every DET B-O
+MIR172 PROPN B-O
+family NOUN B-O
+member NOUN B-O
+in ADP B-O
+the DET B-O
+T1 PROPN B-O
+generation NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1B NUM B-O
+; PUNCT B-O
+S1 PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+GP PROPN B-AC
+, PUNCT B-O
+EBOV NOUN B-LF
+envelope NOUN I-LF
+EBOV PROPN B-AC
+glycoprotein NOUN I-LF
+. PUNCT B-O
+
+We PRON B-O
+used VERB B-O
+a DET B-O
+specific ADJ B-O
+antibody NOUN B-O
+against ADP B-O
+the DET B-O
+promyelocytic ADJ B-LF
+leukemia NOUN I-LF
+( PUNCT B-O
+PML PROPN B-AC
+) PUNCT B-O
+protein NOUN B-O
+to PART B-O
+study VERB B-O
+the DET B-O
+fate NOUN B-O
+of ADP B-O
+the DET B-O
+PML PROPN B-AC
+nuclear ADJ B-O
+bodies NOUN B-O
+, PUNCT B-O
+which PRON B-O
+are AUX B-O
+well ADV B-O
+- PUNCT B-O
+characterized VERB B-O
+subnuclear ADJ B-O
+structures NOUN B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+parallel NOUN B-O
+, PUNCT B-O
+the DET B-O
+rate NOUN B-O
+of ADP B-O
+Caesarean ADJ B-LF
+section NOUN I-LF
+( PUNCT B-O
+C-Section PROPN B-AC
+) PUNCT B-O
+deliveries NOUN B-O
+has AUX B-O
+also ADV B-O
+increased VERB B-O
+dramatically ADV B-O
+over ADP B-O
+the DET B-O
+last ADJ B-O
+decades NOUN B-O
+. PUNCT B-O
+
+• PUNCT B-O
+RLS PROPN B-AC
+diagnosis NOUN B-O
+was AUX B-O
+made VERB B-O
+on ADP B-O
+the DET B-O
+diagnostic ADJ B-O
+criteria NOUN B-O
+of ADP B-O
+the DET B-O
+International PROPN B-O
+Restless PROPN B-LF
+Legs PROPN I-LF
+Syndrome PROPN I-LF
+Study PROPN B-O
+Group PROPN B-O
+( PUNCT B-O
+2010 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+IQR PROPN B-AC
+: PUNCT B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+Similarly ADV B-O
+, PUNCT B-O
+assessment NOUN B-O
+of ADP B-O
+other ADJ B-O
+quantitative ADJ B-O
+variables NOUN B-O
+is AUX B-O
+essential ADJ B-O
+in ADP B-O
+pre- ADJ B-O
+and CCONJ B-O
+post ADJ B-O
+- ADJ B-O
+MI PROPN B-AC
+conditions NOUN B-O
+which PRON B-O
+primarily ADV B-O
+includes VERB B-O
+, PUNCT B-O
+plasma NOUN B-O
+glucose NOUN B-O
+levels NOUN B-O
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+high ADJ B-LF
+density NOUN I-LF
+lipid NOUN I-LF
+( PUNCT B-O
+HDL PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+low ADJ B-LF
+density NOUN I-LF
+lipid NOUN I-LF
+( PUNCT B-O
+LDL PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+triglycerides NOUN B-O
+levels NOUN B-O
+. PUNCT B-O
+
+Fresh ADJ B-O
+IBM PROPN B-O
+suspended VERB B-O
+in ADP B-O
+0.1 NUM B-O
+% PUNCT B-O
+AKRB PROPN B-AC
+were AUX B-O
+centrifuged VERB B-O
+for ADP B-O
+15 NUM B-O
+min NOUN B-O
+at ADP B-O
+800 NUM B-O
+rpm NOUN B-O
+and CCONJ B-O
+immediately ADV B-O
+suspended VERB B-O
+in ADP B-O
+2ml NUM B-O
+of ADP B-O
+Dulbecco PROPN B-LF
+'s PART I-LF
+Modified PROPN I-LF
+Eagle PROPN I-LF
+'s PART I-LF
+( PUNCT B-O
+DMEM PROPN B-AC
+) PUNCT B-O
++ SYM B-O
+BSA0.1 NUM B-O
+% PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+Tem PROPN B-AC
+effects NOUN B-O
+on ADP B-O
+LC3-II PROPN B-AC
+levels NOUN B-O
+were AUX B-O
+also ADV B-O
+preserved VERB B-O
+in ADP B-O
+5 NUM B-LF
+' NOUN I-LF
+adenosine NOUN I-LF
+monophosphate NOUN I-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+AMPK PROPN B-AC
+) PUNCT B-O
+α1 NUM B-O
+/ SYM B-O
+α2 NUM B-O
+double ADJ B-O
+KO PROPN B-AC
+MEFs PROPN B-AC
+( PUNCT B-O
+S6B PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Chronic ADJ B-O
+HBV PROPN B-AC
+infection NOUN B-O
+was AUX B-O
+classified VERB B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+latest ADJ B-O
+European PROPN B-LF
+Association PROPN I-LF
+for ADP I-LF
+the DET I-LF
+Study PROPN I-LF
+of ADP I-LF
+the DET I-LF
+Liver PROPN I-LF
+( PUNCT B-O
+EASL PROPN B-AC
+) PUNCT B-O
+Clinical PROPN B-LF
+Practice PROPN I-LF
+Guidelines PROPN I-LF
+( PUNCT B-O
+CPG PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+CI PROPN B-AC
+, PUNCT B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT B-O
+TBI PROPN B-AC
+, PUNCT B-O
+traumatic ADJ B-LF
+brain NOUN I-LF
+injury NOUN I-LF
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+is AUX B-O
+reported VERB B-O
+as ADP B-O
+per ADP B-O
+the DET B-O
+CONsolidated PROPN B-LF
+Standards PROPN I-LF
+of ADP I-LF
+Reporting PROPN I-LF
+Trials PROPN I-LF
+( PUNCT B-O
+CONSORT PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+S1 PROPN B-O
+CONSORT PROPN B-AC
+Checklist PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+risk NOUN B-O
+of ADP B-O
+ID PROPN B-AC
+increases VERB B-O
+during ADP B-O
+pregnancy NOUN B-O
+due ADP B-O
+to PART B-O
+an DET B-O
+increase NOUN B-O
+in ADP B-O
+maternal ADJ B-O
+iron NOUN B-O
+requirements NOUN B-O
+to PART B-O
+accommodate VERB B-O
+the DET B-O
+expansion NOUN B-O
+of ADP B-O
+maternal ADJ B-O
+red ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+( PUNCT B-O
+RBC PROPN B-AC
+) PUNCT B-O
+mass NOUN B-O
+, PUNCT B-O
+development NOUN B-O
+of ADP B-O
+the DET B-O
+placenta NOUN B-O
+and CCONJ B-O
+fetus NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+loss NOUN B-O
+of ADP B-O
+blood NOUN B-O
+associated VERB B-O
+with ADP B-O
+labor NOUN B-O
+and CCONJ B-O
+delivery NOUN B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+is AUX B-O
+reported VERB B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT B-O
+STROBE PROPN B-AC
+) PUNCT B-O
+statement NOUN B-O
+( PUNCT B-O
+S1 PROPN B-O
+STROBE PROPN B-AC
+Checklist PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Schematic ADJ B-O
+pressure NOUN B-O
+curve NOUN B-O
+of ADP B-O
+a DET B-O
+BiPAP PROPN B-AC
+ventilation NOUN B-O
+( PUNCT B-O
+A NOUN B-O
+) PUNCT B-O
+compared VERB B-O
+to ADP B-O
+ventilation NOUN B-O
+in ADP B-O
+PLBV PROPN B-AC
+mode NOUN B-O
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+BiPAP PROPN B-AC
+: PUNCT B-O
+Bilevel NOUN B-LF
+positive ADJ I-LF
+airway NOUN I-LF
+pressure NOUN I-LF
+; PUNCT B-O
+IPAP PROPN B-AC
+: PUNCT B-O
+inspiratory ADJ B-LF
+positive ADJ I-LF
+airway NOUN I-LF
+pressure NOUN I-LF
+; PUNCT B-O
+EPAP PROPN B-AC
+: PUNCT B-O
+expiratory ADJ B-LF
+positive ADJ I-LF
+airway NOUN I-LF
+pressure NOUN I-LF
+; PUNCT B-O
+PLBV PROPN B-AC
+: PUNCT B-O
+pursed ADJ B-LF
+lips NOUN I-LF
+breathing VERB I-LF
+ventilation NOUN I-LF
+. PUNCT B-O
+
+Sodium PROPN B-LF
+Calcium PROPN I-LF
+exchangers NOUN I-LF
+( PUNCT B-O
+NCX PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+low ADJ B-O
+affinity NOUN B-O
+high ADJ B-O
+capacity NOUN B-O
+( PUNCT B-O
+kcat NOUN B-O
+2000–5000 NUM B-O
+s−1 NUM B-O
+) PUNCT B-O
+antiporters NOUN B-O
+that PRON B-O
+can AUX B-O
+rapidly ADV B-O
+move VERB B-O
+Ca2 NOUN B-O
++ NOUN B-O
+ions NOUN B-O
+across ADP B-O
+the DET B-O
+plasma NOUN B-O
+membrane NOUN B-O
+. PUNCT B-O
+
+Cells NOUN B-O
+were AUX B-O
+left VERB B-O
+to PART B-O
+expand VERB B-O
+for ADP B-O
+3–4 NUM B-O
+consecutive ADJ B-O
+days NOUN B-O
+to PART B-O
+form VERB B-O
+a DET B-O
+confluent ADJ B-O
+monolayer NOUN B-O
+( PUNCT B-O
+unless SCONJ B-O
+stated VERB B-O
+otherwise ADV B-O
+) PUNCT B-O
+before SCONJ B-O
+fixation NOUN B-O
+with ADP B-O
+4 NUM B-O
+% NOUN B-O
+paraformaldehyde NOUN B-LF
+( PUNCT B-O
+PFA PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+performed VERB B-O
+. PUNCT B-O
+
+Moreover ADV B-O
+, PUNCT B-O
+HIF-2α PROPN B-AC
+– PUNCT B-O
+dependent ADJ B-O
+up NOUN B-O
+- PUNCT B-O
+regulation NOUN B-O
+of ADP B-O
+interleukin NOUN B-LF
+( PUNCT B-O
+IL)-6 PROPN B-AC
+in ADP B-O
+FLS PROPN B-AC
+stimulated VERB B-O
+differentiation NOUN B-O
+of ADP B-O
+TH17 NOUN B-O
+cells NOUN B-O
+— PUNCT B-O
+crucial ADJ B-O
+effectors NOUN B-O
+of ADP B-O
+RA PROPN B-AC
+pathogenesis NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+tested VERB B-O
+2 NUM B-O
+low ADJ B-O
+- PUNCT B-O
+intensity NOUN B-O
+versions NOUN B-O
+of ADP B-O
+CBT PROPN B-AC
+in ADP B-O
+a DET B-O
+trial NOUN B-O
+( PUNCT B-O
+guided VERB B-O
+self NOUN B-O
+- PUNCT B-O
+help NOUN B-O
+and CCONJ B-O
+supported VERB B-O
+computerised ADJ B-LF
+cognitive ADJ I-LF
+- PUNCT I-LF
+behaviour NOUN I-LF
+therapy NOUN I-LF
+[ PUNCT B-O
+cCBT PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+testing VERB B-O
+their PRON B-O
+impact NOUN B-O
+on ADP B-O
+patients NOUN B-O
+with ADP B-O
+OCD PROPN B-AC
+when SCONJ B-O
+provided VERB B-O
+prior ADV B-O
+to ADP B-O
+CBT PROPN B-AC
+with ADP B-O
+a DET B-O
+therapist NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+pelvic ADJ B-O
+inlet NOUN B-O
+anterior ADJ B-LF
+- PUNCT I-LF
+posterior ADJ I-LF
+diameter NOUN I-LF
+( PUNCT B-O
+APD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+also ADV B-O
+called VERB B-O
+the DET B-O
+obstetric ADJ B-O
+conjugate NOUN B-O
+, PUNCT B-O
+was AUX B-O
+measured VERB B-O
+from ADP B-O
+the DET B-O
+anterior ADJ B-O
+cortical ADJ B-O
+surface NOUN B-O
+of ADP B-O
+the DET B-O
+sacrovertebral ADJ B-O
+angel NOUN B-O
+( PUNCT B-O
+promontory NOUN B-O
+) PUNCT B-O
+to ADP B-O
+the DET B-O
+closest ADJ B-O
+point NOUN B-O
+on ADP B-O
+the DET B-O
+convex ADJ B-O
+posterior ADJ B-O
+- PUNCT B-O
+superior ADJ B-O
+aspect NOUN B-O
+of ADP B-O
+the DET B-O
+pubis NOUN B-O
+symphysis NOUN B-O
+. PUNCT B-O
+
+By ADP B-O
+contrast NOUN B-O
+, PUNCT B-O
+enhanced VERB B-O
+green ADJ B-O
+- PUNCT B-O
+fusion NOUN B-O
+protein NOUN B-O
+- PUNCT B-O
+maximakinin NOUN B-LF
+( PUNCT B-O
+EGFP PROPN B-AC
+- PUNCT B-O
+MK PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+much ADV B-O
+brighter ADJ B-O
+, PUNCT B-O
+nanomolar ADJ B-O
+affinity NOUN B-O
+agonist NOUN B-O
+of ADP B-O
+the DET B-O
+rabbit NOUN B-O
+B2R PROPN B-AC
+that PRON B-O
+does AUX B-O
+not PART B-O
+bind VERB B-O
+to ADP B-O
+ACE PROPN B-AC
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Currently ADV B-O
+there PRON B-O
+is VERB B-O
+no DET B-O
+standard ADJ B-O
+second ADJ B-O
+- PUNCT B-O
+line NOUN B-O
+treatment NOUN B-O
+for ADP B-O
+steroid NOUN B-LF
+- PUNCT I-LF
+refractory ADJ I-LF
+aGVHD PROPN B-AC
+( PUNCT B-O
+SR PROPN B-AC
+- PUNCT B-O
+aGVHD PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Numerous ADJ B-O
+strategies NOUN B-O
+to PART B-O
+treat VERB B-O
+SR PROPN B-AC
+- PUNCT B-O
+aGVHD PROPN B-AC
+have AUX B-O
+been AUX B-O
+reported VERB B-O
+, PUNCT B-O
+but CCONJ B-O
+results NOUN B-O
+have AUX B-O
+been AUX B-O
+disappointing ADJ B-O
+with ADP B-O
+varying VERB B-O
+response NOUN B-O
+rates NOUN B-O
+and CCONJ B-O
+long ADJ B-O
+term NOUN B-O
+overall ADJ B-LF
+survival NOUN I-LF
+( PUNCT B-O
+OS PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+only ADV B-O
+20–30 NUM B-O
+% NOUN B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Raw ADJ B-O
+data NOUN B-O
+for ADP B-O
+panels NOUN B-O
+A NOUN B-O
+and CCONJ B-O
+B NOUN B-O
+can AUX B-O
+be AUX B-O
+found VERB B-O
+in ADP B-O
+the DET B-O
+Supporting NOUN B-O
+Information NOUN B-O
+section NOUN B-O
+S2 NOUN B-O
+Data NOUN B-O
+file NOUN B-O
+. PUNCT B-O
+
+fMLP PROPN B-AC
+, PUNCT B-O
+N NOUN B-LF
+- PUNCT I-LF
+formylMethionyl NOUN I-LF
+- PUNCT I-LF
+Leucyl NOUN I-LF
+- PUNCT I-LF
+Phenylalanine NOUN I-LF
+; PUNCT B-O
+KD PROPN B-AC
+, PUNCT B-O
+knockdown NOUN B-LF
+; PUNCT B-O
+NSshRNA PROPN B-AC
+, PUNCT B-O
+nonspecific ADJ B-LF
+shRNA NOUN I-LF
+shRNA PROPN B-AC
+. PUNCT B-O
+
+To PART B-O
+determine VERB B-O
+whether SCONJ B-O
+this DET B-O
+inflammatory ADJ B-O
+response NOUN B-O
+is AUX B-O
+reflected VERB B-O
+by ADP B-O
+up NOUN B-O
+- ADJ B-O
+regulation NOUN B-O
+of ADP B-O
+pro ADJ B-O
+- ADJ B-O
+inflammatory ADJ B-O
+markers NOUN B-O
+, PUNCT B-O
+we PRON B-O
+performed VERB B-O
+reverse ADJ B-LF
+transcription NOUN I-LF
+PCR NOUN I-LF
+( PUNCT B-O
+RT-PCR PROPN B-AC
+) PUNCT B-O
+on ADP B-O
+larvae NOUN B-O
+carrying VERB B-O
+a DET B-O
+transformed VERB B-O
+goblet NOUN B-O
+cell NOUN B-O
+burden NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+indeed ADV B-O
+we PRON B-O
+see VERB B-O
+increased VERB B-O
+levels NOUN B-O
+of ADP B-O
+tnfα NOUN B-O
+, PUNCT B-O
+cxcl1 NOUN B-O
+, PUNCT B-O
+il8 NOUN B-O
+, PUNCT B-O
+ifn1 NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+il1β NOUN B-O
+in ADP B-O
+these DET B-O
+larvae NOUN B-O
+( PUNCT B-O
+Figure NOUN B-O
+S1A NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Moreover ADV B-O
+, PUNCT B-O
+if SCONJ B-O
+we PRON B-O
+look VERB B-O
+by ADP B-O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+( PUNCT B-O
+qPCR PROPN B-AC
+) PUNCT B-O
+at ADP B-O
+levels NOUN B-O
+of ADP B-O
+two NUM B-O
+of ADP B-O
+these DET B-O
+genes NOUN B-O
+, PUNCT B-O
+il1β NOUN B-O
+and CCONJ B-O
+cxcl1 NOUN B-O
+, PUNCT B-O
+we PRON B-O
+see VERB B-O
+their PRON B-O
+clear ADJ B-O
+induction NOUN B-O
+in ADP B-O
+larvae NOUN B-O
+where SCONJ B-O
+V12RAS NOUN B-O
+expression NOUN B-O
+is AUX B-O
+induced VERB B-O
+by ADP B-O
+heat NOUN B-O
+shock NOUN B-O
+only ADV B-O
+6 NUM B-O
+h NOUN B-O
+before ADP B-O
+RNA NOUN B-O
+extraction NOUN B-O
+, PUNCT B-O
+suggesting VERB B-O
+that SCONJ B-O
+pro ADJ B-O
+- ADJ B-O
+inflammatory ADJ B-O
+gene NOUN B-O
+expression NOUN B-O
+is AUX B-O
+a DET B-O
+rapid ADJ B-O
+response NOUN B-O
+to ADP B-O
+V12RAS NOUN B-O
+expression NOUN B-O
+( PUNCT B-O
+Figure NOUN B-O
+S1B NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Replacing VERB B-O
+NNRTIs PROPN B-AC
+by ADP B-O
+dolutegravir PROPN B-LF
+( PUNCT B-O
+DTG PROPN B-AC
+) PUNCT B-O
+may AUX B-O
+curb VERB B-O
+the DET B-O
+spread NOUN B-O
+of ADP B-O
+resistance NOUN B-O
+, PUNCT B-O
+but CCONJ B-O
+it PRON B-O
+is AUX B-O
+unclear ADJ B-O
+how SCONJ B-O
+effective ADJ B-O
+this DET B-O
+switch NOUN B-O
+will AUX B-O
+be AUX B-O
+and CCONJ B-O
+which DET B-O
+patient NOUN B-O
+groups NOUN B-O
+should AUX B-O
+be AUX B-O
+switched VERB B-O
+from ADP B-O
+NNRTI PROPN B-AC
+to ADP B-O
+DTG PROPN B-AC
+. PUNCT B-O
+
+Transcriptome ADJ B-O
+sequencing NOUN B-O
+analysis NOUN B-O
+detected VERB B-O
+106 NUM B-O
+differentially ADV B-LF
+expressed VERB I-LF
+genes NOUN I-LF
+( PUNCT B-O
+DEGs PROPN B-AC
+) PUNCT B-O
+related VERB B-O
+to ADP B-O
+oxidative ADJ B-O
+stress NOUN B-O
+. PUNCT B-O
+
+Finally ADV B-O
+, PUNCT B-O
+demographic ADJ B-O
+information NOUN B-O
+was AUX B-O
+collected VERB B-O
+, PUNCT B-O
+including VERB B-O
+the DET B-O
+Integrated PROPN B-LF
+Systematic PROPN I-LF
+Care PROPN I-LF
+for ADP I-LF
+Older PROPN I-LF
+People PROPN I-LF
+( PUNCT B-O
+ISCOPE PROPN B-AC
+) PUNCT B-O
+questionnaire NOUN B-O
+, PUNCT B-O
+to PART B-O
+determine VERB B-O
+complex ADJ B-O
+health NOUN B-O
+problems NOUN B-O
+in ADP B-O
+the DET B-O
+participants NOUN B-O
+[ PUNCT B-O
+35 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+chicken NOUN B-O
+appears VERB B-O
+to PART B-O
+lack VERB B-O
+the DET B-O
+ortholog NOUN B-O
+for ADP B-O
+the DET B-O
+human ADJ B-O
+GABABR PROPN B-AC
+( PUNCT B-O
+gamma NOUN B-LF
+aminobutyric ADJ I-LF
+acid NOUN I-LF
+– PUNCT I-LF
+binding VERB I-LF
+receptor NOUN I-LF
+) PUNCT B-O
+1 NUM B-O
+. PUNCT B-O
+
+Mice NOUN B-O
+8–10 NUM B-O
+weeks NOUN B-O
+old ADJ B-O
+infected VERB B-O
+intraperitoneally ADV B-O
+with ADP B-O
+102 NUM B-O
+( PUNCT B-O
+A&E NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+103 NUM B-O
+( PUNCT B-O
+B&F NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+104 NUM B-O
+( PUNCT B-O
+C&G NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+106 NUM B-O
+( PUNCT B-O
+D&H NOUN B-O
+) PUNCT B-O
+plaque NOUN B-O
+forming VERB B-O
+units NOUN B-O
+( PUNCT B-O
+pfu NOUN B-O
+) PUNCT B-O
+Smith PROPN B-O
+strain NOUN B-O
+mCMV PROPN B-AC
+had VERB B-O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT B-O
+PBMC PROPN B-AC
+) PUNCT B-O
+evaluated VERB B-O
+16 NUM B-O
+weeks NOUN B-O
+after ADP B-O
+infection NOUN B-O
+for ADP B-O
+inflationary ADJ B-O
+mCMV PROPN B-AC
+- PUNCT B-O
+specific ADJ B-O
+T NOUN B-O
+- PUNCT B-O
+cells NOUN B-O
+. PUNCT B-O
+
+Error NOUN B-O
+bars NOUN B-O
+were AUX B-O
+equal ADJ B-O
+to ADP B-O
+the DET B-O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+( PUNCT B-O
+SEM PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+a DET B-O
+subset NOUN B-O
+of ADP B-O
+the DET B-O
+local ADJ B-O
+UIs PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+subset NOUN B-O
+was AUX B-O
+chosen VERB B-O
+so SCONJ B-O
+that SCONJ B-O
+no DET B-O
+two NUM B-O
+triangles NOUN B-O
+shared VERB B-O
+an DET B-O
+edge NOUN B-O
+, PUNCT B-O
+ensuring VERB B-O
+that SCONJ B-O
+local ADJ B-O
+correlations NOUN B-O
+in ADP B-O
+the DET B-O
+UI PROPN B-AC
+did AUX B-O
+not PART B-O
+artificially ADV B-O
+reduce VERB B-O
+the DET B-O
+SEM PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+SEM PROPN B-AC
+was AUX B-O
+validated VERB B-O
+using VERB B-O
+a DET B-O
+bootstrap NOUN B-O
+simulation NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+find VERB B-O
+that SCONJ B-O
+parasites NOUN B-O
+undergoing VERB B-O
+delayed VERB B-O
+death NOUN B-O
+exhibited VERB B-O
+disrupted VERB B-O
+prenylation NOUN B-O
+of ADP B-O
+proteins NOUN B-O
+required VERB B-O
+for ADP B-O
+haemoglobin NOUN B-O
+uptake NOUN B-O
+and CCONJ B-O
+the DET B-O
+biogenesis NOUN B-O
+of ADP B-O
+the DET B-O
+digestive ADJ B-LF
+vacuole NOUN I-LF
+( PUNCT B-O
+DV PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+further ADV B-O
+demonstrate VERB B-O
+defective ADJ B-O
+localisation NOUN B-O
+of ADP B-O
+prenylated VERB B-O
+trafficking NOUN B-O
+mediators NOUN B-O
+, PUNCT B-O
+defective ADJ B-O
+uptake NOUN B-O
+of ADP B-O
+haemoglobin NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+a DET B-O
+disrupted VERB B-O
+DV PROPN B-AC
+in ADP B-O
+these DET B-O
+parasites NOUN B-O
+. PUNCT B-O
+
+Tuberculosis NOUN B-LF
+( PUNCT B-O
+TB PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+one NUM B-O
+of ADP B-O
+the DET B-O
+leading VERB B-O
+causes NOUN B-O
+of ADP B-O
+death NOUN B-O
+from ADP B-O
+infectious ADJ B-O
+disease NOUN B-O
+worldwide ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+it PRON B-O
+kills VERB B-O
+around ADV B-O
+1.7 NUM B-O
+million NUM B-O
+people NOUN B-O
+each DET B-O
+year NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+brief NOUN B-O
+, PUNCT B-O
+a DET B-O
+simplified ADJ B-O
+form NOUN B-O
+of ADP B-O
+sepsis NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+organ NOUN B-LF
+failure NOUN I-LF
+assessment NOUN I-LF
+( PUNCT B-O
+SOFA PROPN B-AC
+) PUNCT B-O
+score NOUN B-O
+[ PUNCT B-O
+23]-based VERB B-O
+scoring NOUN B-O
+system NOUN B-O
+, PUNCT B-O
+the DET B-O
+CLIF-C PROPN B-AC
+OF PROPN B-AC
+score NOUN B-O
+, PUNCT B-O
+was AUX B-O
+used VERB B-O
+to PART B-O
+evaluate VERB B-O
+OF PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+CLIF PROPN B-AC
+-CACLF PROPN B-AC
+score NOUN B-O
+was AUX B-O
+developed VERB B-O
+by ADP B-O
+combining VERB B-O
+the DET B-O
+CLIF PROPN B-AC
+-COF PROPN B-AC
+score NOUN B-O
+and CCONJ B-O
+two NUM B-O
+other ADJ B-O
+independent ADJ B-O
+prognostic ADJ B-O
+factors NOUN B-O
+, PUNCT B-O
+age NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+white ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+( PUNCT B-O
+WBC PROPN B-AC
+) PUNCT B-O
+count NOUN B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+three NUM B-O
+- ADJ B-O
+parameter NOUN B-O
+model NOUN B-O
+that PRON B-O
+did AUX B-O
+not PART B-O
+incorporate VERB B-O
+inter ADJ B-O
+- ADJ B-O
+item ADJ B-O
+homogeneity NOUN B-O
+( PUNCT B-O
+as SCONJ B-O
+shown VERB B-O
+in ADP B-O
+Figure NOUN B-O
+8A NUM B-O
+) PUNCT B-O
+accounted VERB B-O
+for ADP B-O
+only ADV B-O
+51 NUM B-O
+% NOUN B-O
+of ADP B-O
+the DET B-O
+variance NOUN B-O
+( PUNCT B-O
+r NOUN B-O
+2 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+had VERB B-O
+an DET B-O
+Akaike PROPN B-LF
+information NOUN I-LF
+criterion NOUN I-LF
+( PUNCT B-O
+AIC PROPN B-AC
+) PUNCT B-O
+value NOUN B-O
+( PUNCT B-O
+see VERB B-O
+Methods NOUN B-O
+) PUNCT B-O
+of ADP B-O
+1,010 NUM B-O
+( PUNCT B-O
+higher ADJ B-O
+AIC PROPN B-AC
+values NOUN B-O
+indicate VERB B-O
+worse ADJ B-O
+fit NOUN B-O
+[ X B-O
+27 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+D13 NOUN B-O
+, PUNCT B-O
+diploid ADJ B-O
+cycle NOUN B-O
+13 NUM B-O
+embryos NOUN B-O
+; PUNCT B-O
+eve2 PROPN B-AC
+, PUNCT B-O
+even ADV B-LF
+skipped VERB I-LF
+stripe NOUN I-LF
+2 NUM I-LF
+; PUNCT B-O
+Frs PROPN B-AC
+, PUNCT B-O
+Frühstart NOUN B-LF
+; PUNCT B-O
+H14 NOUN B-O
+, PUNCT B-O
+haploid ADJ B-O
+cycle NOUN B-O
+14 NUM B-O
+embryos NOUN B-O
+; PUNCT B-O
+kni PROPN B-AC
+, PUNCT B-O
+knirps NOUN B-LF
+; PUNCT B-O
+N PROPN B-AC
+, PUNCT B-O
+ratio NOUN B-LF
+of ADP I-LF
+nuclei NOUN I-LF
+to ADP I-LF
+cytoplasm NOUN I-LF
+; PUNCT B-O
+PCNA PROPN B-O
+, PUNCT B-O
+proliferating VERB B-O
+cell NOUN B-O
+nuclear ADJ B-O
+antigen NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+ectopically ADV B-O
+expressed VERB B-O
+N. PROPN B-O
+crassa NOUN B-O
+Puf3 PROPN B-O
+protein NOUN B-O
+fused VERB B-O
+to ADP B-O
+a DET B-O
+tandem NOUN B-LF
+affinity NOUN I-LF
+purification NOUN I-LF
+tag NOUN I-LF
+( PUNCT B-O
+TAP-tag PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+a DET B-O
+S. PROPN B-O
+cerevisiae NOUN B-O
+strain NOUN B-O
+missing VERB B-O
+endogenous ADJ B-O
+Puf PROPN B-AC
+proteins NOUN B-O
+, PUNCT B-O
+Puf1 PROPN B-O
+- PUNCT B-O
+5 NUM B-O
+( PUNCT B-O
+derived VERB B-O
+from ADP B-O
+5Δpufs NOUN B-O
+strain NOUN B-O
+[ PUNCT B-O
+47 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+we PRON B-O
+identified VERB B-O
+the DET B-O
+RNAs NOUN B-O
+bound VERB B-O
+by ADP B-O
+N. PROPN B-O
+crassa NOUN B-O
+Puf3 PROPN B-O
+( PUNCT B-O
+Materials NOUN B-O
+and CCONJ B-O
+Methods PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+periodicity NOUN B-O
+was AUX B-O
+evident ADJ B-O
+when SCONJ B-O
+we PRON B-O
+aligned VERB B-O
+all DET B-O
+coding VERB B-O
+regions NOUN B-O
+to ADP B-O
+the DET B-O
+first ADJ B-O
+nucleosome NOUN B-O
+downstream ADV B-O
+of ADP B-O
+the DET B-O
+TSS PROPN B-AC
+and CCONJ B-O
+ranked VERB B-O
+all DET B-O
+these DET B-O
+genes NOUN B-O
+by ADP B-O
+a DET B-O
+nucleosome NOUN B-LF
+positioning NOUN I-LF
+periodicity NOUN I-LF
+( PUNCT B-O
+NPP PROPN B-AC
+) PUNCT B-O
+score NOUN B-O
+applied VERB B-O
+to ADP B-O
+the DET B-O
+coding VERB B-O
+region NOUN B-O
+( PUNCT B-O
+Figure NOUN B-O
+3A NUM B-O
+; PUNCT B-O
+Materials NOUN B-O
+and CCONJ B-O
+Methods NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Therefore ADV B-O
+, PUNCT B-O
+the DET B-O
+study NOUN B-O
+aimed VERB B-O
+to ADP B-O
+suggest VERB B-O
+the DET B-O
+chemical ADJ B-O
+composition NOUN B-O
+of ADP B-O
+C. PROPN B-O
+obtusa PROPN B-O
+leaf NOUN B-O
+extract NOUN B-O
+using VERB B-O
+LC PROPN B-O
+- PUNCT B-O
+MS PROPN B-O
+. PUNCT B-O
+
+To PART B-O
+assess VERB B-O
+if SCONJ B-O
+, PUNCT B-O
+besides SCONJ B-O
+the DET B-O
+antioxidant ADJ B-O
+activity NOUN B-O
+, PUNCT B-O
+C. PROPN B-O
+obtusa PROPN B-O
+would AUX B-O
+exhibit VERB B-O
+an DET B-O
+anti ADJ B-O
+aging ADJ B-O
+effect NOUN B-O
+and CCONJ B-O
+which DET B-O
+mechanisms NOUN B-O
+would AUX B-O
+be AUX B-O
+involved VERB B-O
+in ADP B-O
+it PRON B-O
+, PUNCT B-O
+we PRON B-O
+evaluated VERB B-O
+the DET B-O
+effect NOUN B-O
+of ADP B-O
+the DET B-O
+extract NOUN B-O
+on ADP B-O
+keratinocytes NOUN B-O
+and CCONJ B-O
+fibroblasts NOUN B-O
+exposed VERB B-O
+to ADP B-O
+UV PROPN B-AC
+radiation NOUN B-O
+and CCONJ B-O
+analyzed VERB B-O
+protein NOUN B-O
+carbonyl NOUN B-O
+, PUNCT B-O
+collagen NOUN B-O
+, PUNCT B-O
+hyaluronic ADJ B-LF
+acid NOUN I-LF
+( PUNCT B-O
+HA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+metalloproteinase-1 NOUN B-O
+( PUNCT B-O
+MMP-1 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+IL-1 NOUN B-O
+β PUNCT B-O
+and CCONJ B-O
+IL-6 NOUN B-O
+contents NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+first ADV B-O
+analyzed VERB B-O
+differences NOUN B-O
+between ADP B-O
+wards NOUN B-O
+on ADP B-O
+the DET B-O
+activity NOUN B-O
+categories NOUN B-O
+: PUNCT B-O
+Direct PROPN B-LF
+Patient PROPN I-LF
+Care PROPN I-LF
+( PUNCT B-O
+DPC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Collective PROPN B-LF
+Patient PROPN I-LF
+Care PROPN I-LF
+( PUNCT B-O
+CPC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+General PROPN B-LF
+Tasks PROPN I-LF
+( PUNCT B-O
+GT PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Other ADJ B-LF
+Tasks PROPN I-LF
+( PUNCT B-O
+OT PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Compositional ADJ B-O
+analysis NOUN B-O
+dictates VERB B-O
+that SCONJ B-O
+one NUM B-O
+variable NOUN B-O
+needs VERB B-O
+to PART B-O
+be AUX B-O
+chosen VERB B-O
+as ADP B-O
+a DET B-O
+reference NOUN B-O
+variable NOUN B-O
+, PUNCT B-O
+to PART B-O
+compare VERB B-O
+the DET B-O
+others NOUN B-O
+against ADP B-O
+. PUNCT B-O
+
+Specifically ADV B-O
+, PUNCT B-O
+we PRON B-O
+loaded VERB B-O
+retinas NOUN B-O
+using VERB B-O
+the DET B-O
+acetoxymethyl NOUN B-LF
+ester NOUN I-LF
+( PUNCT B-O
+AM-ester PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+this DET B-O
+dye NOUN B-O
+( PUNCT B-O
+see VERB B-O
+Methods NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+then ADV B-O
+we PRON B-O
+mechanically ADV B-O
+dissociated VERB B-O
+individual ADJ B-O
+rod NOUN B-O
+photoreceptors NOUN B-O
+and/or CCONJ B-O
+OSs PROPN B-AC
+. PUNCT B-O
+
+We PRON B-O
+viewed VERB B-O
+the DET B-O
+preparation NOUN B-O
+using VERB B-O
+IR PROPN B-AC
+illumination NOUN B-O
+at ADP B-O
+750 NUM B-O
+nm NOUN B-O
+and CCONJ B-O
+an DET B-O
+IR PROPN B-AC
+- PUNCT B-O
+sensitive ADJ B-O
+video NOUN B-O
+camera NOUN B-O
+attached VERB B-O
+to ADP B-O
+the DET B-O
+microscope NOUN B-O
+. PUNCT B-O
+
+For ADP B-O
+some DET B-O
+years NOUN B-O
+, PUNCT B-O
+the DET B-O
+maximum ADJ B-LF
+relaxation NOUN I-LF
+rate NOUN I-LF
+( PUNCT B-O
+MRR PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+the DET B-O
+inspiratory ADJ B-O
+muscles NOUN B-O
+has AUX B-O
+been AUX B-O
+used VERB B-O
+as ADP B-O
+an DET B-O
+indirect ADJ B-O
+marker NOUN B-O
+of ADP B-O
+fatigue NOUN B-O
+and CCONJ B-O
+overload NOUN B-O
+of ADP B-O
+the DET B-O
+inspiratory ADJ B-O
+muscles NOUN B-O
+. PUNCT B-O
+
+Zhang PROPN B-O
+et PROPN B-O
+al NOUN B-O
+. PUNCT B-O
+
+[ X B-O
+16 X B-O
+] X B-O
+demonstrated VERB B-O
+that SCONJ B-O
+Shp2 PROPN B-O
+controls VERB B-O
+phosphorylation NOUN B-O
+and CCONJ B-O
+activation NOUN B-O
+of ADP B-O
+Src PROPN B-LF
+family NOUN I-LF
+kinases NOUN I-LF
+( PUNCT B-O
+SFKs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+that SCONJ B-O
+SFK PROPN B-AC
+activity NOUN B-O
+is AUX B-O
+reduced VERB B-O
+in ADP B-O
+the DET B-O
+absence NOUN B-O
+of ADP B-O
+Shp2 PROPN B-O
+, PUNCT B-O
+due ADP B-O
+to ADP B-O
+hyperphosphorylation NOUN B-O
+of ADP B-O
+the DET B-O
+inhibitory ADJ B-O
+phosphorylation NOUN B-O
+site NOUN B-O
+. PUNCT B-O
+
+PAM PROPN B-AC
+, PUNCT B-O
+protospacer NOUN B-LF
+adjacent ADJ I-LF
+motif NOUN I-LF
+; PUNCT B-O
+SpCas9 PROPN B-AC
+, PUNCT B-O
+Streptococcus NOUN B-LF
+pyogenes NOUN I-LF
+Cas9 PROPN I-LF
+; PUNCT B-O
+WT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT B-O
+
+Anthranilic ADJ B-LF
+acid NOUN I-LF
+( PUNCT B-O
+AA PROPN B-AC
+) PUNCT B-O
+supplementation NOUN B-O
+rescues VERB B-O
+gut NOUN B-O
+granule NOUN B-O
+and CCONJ B-O
+DF PROPN B-AC
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+, PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+Incubation NOUN B-O
+of ADP B-O
+tdo-2(RNAi NOUN B-O
+) PUNCT B-O
+worms NOUN B-O
+in ADP B-O
+5 NUM B-O
+mM PROPN B-O
+AA PROPN B-AC
+leads VERB B-O
+to ADP B-O
+gut NOUN B-O
+granule NOUN B-O
+fluorescence NOUN B-O
+similar ADJ B-O
+to ADP B-O
+wild ADJ B-O
+type NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+Effect NOUN B-O
+on ADP B-O
+gut NOUN B-O
+granule NOUN B-O
+fluorescence NOUN B-O
+of ADP B-O
+incubation NOUN B-O
+in ADP B-O
+a DET B-O
+range NOUN B-O
+of ADP B-O
+AA PROPN B-AC
+concentrations NOUN B-O
+. PUNCT B-O
+
+5 NUM B-O
+mM PROPN B-O
+AA PROPN B-AC
+gives VERB B-O
+fluorescence NOUN B-O
+levels NOUN B-O
+similar ADJ B-O
+to ADP B-O
+wild ADJ B-O
+type NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+Epifluorescence NOUN B-O
+microscopy NOUN B-O
+reveals VERB B-O
+restoration NOUN B-O
+of ADP B-O
+gut NOUN B-O
+granule NOUN B-O
+fluorescence NOUN B-O
+by ADP B-O
+incubation NOUN B-O
+in ADP B-O
+5 NUM B-O
+mM PROPN B-O
+AA PROPN B-AC
+. PUNCT B-O
+
+( PUNCT B-O
+C X B-O
+, PUNCT B-O
+D NOUN B-O
+) PUNCT B-O
+Incubation NOUN B-O
+of ADP B-O
+tdo-2(RNAi NOUN B-O
+) PUNCT B-O
+worms NOUN B-O
+in ADP B-O
+5 NUM B-O
+mM PROPN B-O
+AA PROPN B-AC
+leads VERB B-O
+to ADP B-O
+DF PROPN B-AC
+similar ADJ B-O
+to ADP B-O
+wild ADJ B-O
+type NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+C X B-O
+) PUNCT B-O
+Effects NOUN B-O
+of ADP B-O
+tdo-2(RNAi NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+AA PROPN B-AC
+supplementation NOUN B-O
+on ADP B-O
+peak ADJ B-O
+DF PROPN B-AC
+. PUNCT B-O
+
+( PUNCT B-O
+D NOUN B-O
+) PUNCT B-O
+Similar ADJ B-O
+kinetics NOUN B-O
+of ADP B-O
+DF PROPN B-AC
+in ADP B-O
+control NOUN B-O
+worms NOUN B-O
+and CCONJ B-O
+tdo-2(RNAi NOUN B-O
+) PUNCT B-O
+worms NOUN B-O
+with ADP B-O
+AA PROPN B-AC
+- PUNCT B-O
+replenished VERB B-O
+gut NOUN B-O
+granules NOUN B-O
+, PUNCT B-O
+even ADV B-O
+though SCONJ B-O
+only ADV B-O
+the DET B-O
+former ADJ B-O
+can AUX B-O
+synthesize VERB B-O
+AA PROPN B-AC
+. PUNCT B-O
+
+Signal ADJ B-LF
+transducer NOUN I-LF
+and CCONJ I-LF
+activator NOUN I-LF
+of ADP I-LF
+transcription NOUN I-LF
+5b NOUN I-LF
+( PUNCT B-O
+STAT5b PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+one NUM B-O
+of ADP B-O
+seven NUM B-O
+mammalian ADJ B-O
+STAT PROPN B-O
+transcription NOUN B-O
+factors NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+, PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Oxidative ADJ B-O
+stress NOUN B-O
+refers VERB B-O
+to PART B-O
+the DET B-O
+imbalance NOUN B-O
+between ADP B-O
+the DET B-O
+products NOUN B-O
+of ADP B-O
+reactive ADJ B-LF
+oxygen NOUN I-LF
+species NOUN I-LF
+( PUNCT B-O
+ROS PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+biological ADJ B-O
+ability NOUN B-O
+to PART B-O
+detoxify VERB B-O
+them PRON B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+U5 PROPN B-O
+is AUX B-O
+identical ADJ B-O
+to ADP B-O
+U3 PROPN B-O
+except SCONJ B-O
+that SCONJ B-O
+it PRON B-O
+lacks VERB B-O
+the DET B-O
+third ADJ B-O
+randomized VERB B-O
+ankyrin NOUN B-LF
+repeat NOUN I-LF
+( PUNCT B-O
+AR PROPN B-AC
+) PUNCT B-O
+domain NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+used VERB B-O
+an DET B-O
+iterative ADJ B-O
+immuno ADJ B-O
+- PUNCT B-O
+FISH PROPN B-AC
+( PUNCT B-O
+fluorescence NOUN B-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+) PUNCT B-O
+approach NOUN B-O
+[ X B-O
+41 X B-O
+] X B-O
+to ADP B-O
+investigate VERB B-O
+the DET B-O
+organization NOUN B-O
+of ADP B-O
+the DET B-O
+chromosome NOUN B-O
+loops NOUN B-O
+associated VERB B-O
+with ADP B-O
+pairs NOUN B-O
+of ADP B-O
+sister NOUN B-O
+chromatids NOUN B-O
+, PUNCT B-O
+both PRON B-O
+relative ADJ B-O
+to ADP B-O
+each DET B-O
+other ADJ B-O
+and CCONJ B-O
+in ADP B-O
+relationship NOUN B-O
+to ADP B-O
+the DET B-O
+chromosome NOUN B-O
+axis NOUN B-O
+. PUNCT B-O
+
+Historically ADV B-O
+, PUNCT B-O
+PJP PROPN B-AC
+affects VERB B-O
+mostly ADV B-O
+patients NOUN B-O
+with ADP B-O
+human ADJ B-LF
+immunodeficiency NOUN I-LF
+virus NOUN I-LF
+( PUNCT B-O
+HIV PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+prevalence NOUN B-O
+of ADP B-O
+patients NOUN B-O
+with ADP B-O
+HIV PROPN B-AC
+- PUNCT B-O
+related VERB B-O
+PJP PROPN B-AC
+has AUX B-O
+decreased VERB B-O
+with ADP B-O
+the DET B-O
+use NOUN B-O
+of ADP B-O
+highly ADV B-O
+active ADJ B-O
+antiretroviral ADJ B-O
+therapy NOUN B-O
+and CCONJ B-O
+routine ADJ B-O
+PJP PROPN B-AC
+prophylaxis NOUN B-O
+[ X B-O
+1,2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+AID PROPN B-AC
+, PUNCT B-O
+auxin X B-LF
+- PUNCT I-LF
+inducible NOUN I-LF
+degron PROPN I-LF
+. PUNCT B-O
+
+We PRON B-O
+calculated VERB B-O
+the DET B-O
+GSCORR PROPN B-AC
+under ADP B-O
+three NUM B-O
+procedures NOUN B-O
+of ADP B-O
+noise NOUN B-O
+regression NOUN B-O
+: PUNCT B-O
+( PUNCT B-O
+1 X B-O
+) PUNCT B-O
+without ADP B-O
+any DET B-O
+noise NOUN B-O
+regression NOUN B-O
+, PUNCT B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+regressors NOUN B-O
+including VERB B-O
+head NOUN B-O
+motion NOUN B-O
+and CCONJ B-O
+signals NOUN B-O
+from ADP B-O
+the DET B-O
+ventricle NOUN B-O
+and CCONJ B-O
+white ADJ B-O
+matter NOUN B-O
+as SCONJ B-O
+well ADV B-O
+as SCONJ B-O
+their PRON B-O
+first ADJ B-O
+order NOUN B-O
+derivatives NOUN B-O
+, PUNCT B-O
+( PUNCT B-O
+3 X B-O
+) PUNCT B-O
+regressors NOUN B-O
+including VERB B-O
+those PRON B-O
+in ADP B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+plus CCONJ B-O
+the DET B-O
+RVT PROPN B-AC
+and CCONJ B-O
+heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT B-O
+HR PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+If SCONJ B-O
+the DET B-O
+task NOUN B-O
+modulation NOUN B-O
+of ADP B-O
+GSCORR PROPN B-AC
+( PUNCT B-O
+i.e. X B-O
+, PUNCT B-O
+ΔGSCORR NOUN B-O
+) PUNCT B-O
+was AUX B-O
+driven VERB B-O
+merely ADV B-O
+by ADP B-O
+noise NOUN B-O
+, PUNCT B-O
+then ADV B-O
+its PRON B-O
+spatial ADJ B-O
+pattern NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+calculated VERB B-O
+without ADP B-O
+noise NOUN B-O
+, PUNCT B-O
+should AUX B-O
+show VERB B-O
+low ADJ B-O
+degrees NOUN B-O
+of ADP B-O
+spatial ADJ B-O
+similarity NOUN B-O
+with ADP B-O
+the DET B-O
+one NUM B-O
+after ADP B-O
+noise NOUN B-O
+regression NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+overcome VERB B-O
+the DET B-O
+effects NOUN B-O
+of ADP B-O
+heterogeneous ADJ B-O
+ELF5 PROPN B-O
+induction NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1A NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+performed VERB B-O
+intraductal ADJ B-O
+allografts NOUN B-O
+of ADP B-O
+Fluorescence PROPN B-LF
+- PUNCT I-LF
+Activated VERB I-LF
+Cell PROPN I-LF
+Sorting PROPN I-LF
+( PUNCT B-O
+FACS)-sorted PROPN B-AC
+( PUNCT B-O
+Lin- PROPN B-O
+and CCONJ B-O
+CD24 PROPN B-O
++ PUNCT B-O
+) PUNCT B-O
+tumor NOUN B-O
+cells NOUN B-O
+that PRON B-O
+were AUX B-O
+either CCONJ B-O
+EGFP PROPN B-O
+( PUNCT B-O
+ELF5 PROPN B-O
+) PUNCT B-O
+positive ADJ B-O
+or CCONJ B-O
+negative ADJ B-O
+. PUNCT B-O
+
+Recently ADV B-O
+, PUNCT B-O
+Anaplastic ADJ B-LF
+Lymphoma PROPN I-LF
+Kinase PROPN I-LF
+( PUNCT B-O
+ALK PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+receptor NOUN B-O
+kinase NOUN B-O
+involved VERB B-O
+in ADP B-O
+pro ADJ B-O
+- ADJ B-O
+survival ADJ B-O
+signaling NOUN B-O
+, PUNCT B-O
+was AUX B-O
+shown VERB B-O
+to PART B-O
+be AUX B-O
+upregulated ADJ B-O
+in ADP B-O
+advanced ADJ B-O
+/ SYM B-O
+metastatic ADJ B-O
+neuroblastomas NOUN B-O
+[ PUNCT B-O
+13 NUM B-O
+, PUNCT B-O
+14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+one NUM B-O
+- PUNCT B-O
+stage NOUN B-O
+approach NOUN B-O
+, PUNCT B-O
+we PRON B-O
+added VERB B-O
+a DET B-O
+second ADJ B-O
+sensitivity NOUN B-O
+analysis NOUN B-O
+to PART B-O
+compare VERB B-O
+our PRON B-O
+results NOUN B-O
+against ADP B-O
+those PRON B-O
+of ADP B-O
+a DET B-O
+procedure NOUN B-O
+applying VERB B-O
+multiple ADJ B-O
+imputation NOUN B-O
+to PART B-O
+include VERB B-O
+all DET B-O
+participants NOUN B-O
+( PUNCT B-O
+an DET B-O
+intention NOUN B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+treat VERB I-LF
+[ X B-O
+ITT PROPN B-AC
+] X B-O
+analysis NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Previous ADJ B-O
+work NOUN B-O
+by ADP B-O
+our PRON B-O
+group NOUN B-O
+reported VERB B-O
+that SCONJ B-O
+long ADJ B-O
+- PUNCT B-O
+term NOUN B-O
+, PUNCT B-O
+ambient ADJ B-O
+PM PROPN B-AC
+exposure NOUN B-O
+induces VERB B-O
+hepatic ADJ B-O
+fibrosis NOUN B-O
+and CCONJ B-O
+increased VERB B-O
+ROS NOUN B-O
+production NOUN B-O
+in ADP B-O
+the DET B-O
+liver NOUN B-O
+in ADP B-O
+mice NOUN B-O
+; PUNCT B-O
+the DET B-O
+combination NOUN B-O
+of ADP B-O
+PM PROPN B-AC
+exposure NOUN B-O
+and CCONJ B-O
+a DET B-O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+( PUNCT B-O
+HFD PROPN B-AC
+) PUNCT B-O
+aggravates VERB B-O
+hepatic ADJ B-O
+fibrosis NOUN B-O
+[ PUNCT B-O
+11 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+subsidy NOUN B-O
+level NOUN B-O
+of ADP B-O
+30 NUM B-O
+% NOUN B-O
+was AUX B-O
+based VERB B-O
+on ADP B-O
+the DET B-O
+subsidy NOUN B-O
+level NOUN B-O
+used VERB B-O
+in ADP B-O
+the DET B-O
+US PROPN B-O
+Department PROPN B-O
+of ADP B-O
+Agriculture PROPN B-O
+’s PART B-O
+( PUNCT B-O
+USDA PROPN B-AC
+’s PART B-O
+) PUNCT B-O
+Healthy PROPN B-LF
+Incentives PROPN I-LF
+Pilot PROPN I-LF
+( PUNCT B-O
+HIP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+randomized ADJ B-O
+controlled ADJ B-O
+trial NOUN B-O
+implemented VERB B-O
+among ADP B-O
+Supplemental PROPN B-LF
+Nutrition PROPN I-LF
+Assistant PROPN I-LF
+Program PROPN I-LF
+( PUNCT B-O
+SNAP PROPN B-AC
+) PUNCT B-O
+participants NOUN B-O
+to PART B-O
+incentivize VERB B-O
+F&V PROPN B-AC
+consumption NOUN B-O
+[ PUNCT B-O
+37 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This PRON B-O
+is AUX B-O
+of ADP B-O
+particular ADJ B-O
+relevance NOUN B-O
+because SCONJ B-O
+obesity NOUN B-O
+is AUX B-O
+a DET B-O
+risk NOUN B-O
+factor NOUN B-O
+for ADP B-O
+a DET B-O
+number NOUN B-O
+of ADP B-O
+cancer NOUN B-O
+types NOUN B-O
+, PUNCT B-O
+including VERB B-O
+multiple ADJ B-LF
+myeloma NOUN I-LF
+( PUNCT B-O
+MM PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+During ADP B-O
+the DET B-O
+past NOUN B-O
+decade NOUN B-O
+, PUNCT B-O
+large ADJ B-O
+- PUNCT B-O
+scale NOUN B-O
+implementation NOUN B-O
+of ADP B-O
+long ADV B-LF
+- PUNCT I-LF
+lasting VERB I-LF
+insecticidal ADJ I-LF
+nets NOUN I-LF
+( PUNCT B-O
+LLINs PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+indoor ADJ B-LF
+residual ADJ I-LF
+spraying NOUN I-LF
+( PUNCT B-O
+IRS PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+played VERB B-O
+a DET B-O
+major ADJ B-O
+role NOUN B-O
+in ADP B-O
+reducing VERB B-O
+malaria NOUN B-O
+morbidity NOUN B-O
+and CCONJ B-O
+mortality NOUN B-O
+in ADP B-O
+Africa PROPN B-O
+south ADV B-O
+of ADP B-O
+the DET B-O
+Sahara PROPN B-O
+[ PUNCT B-O
+2 NUM B-O
+, PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+represent VERB B-O
+the DET B-O
+concentrations NOUN B-O
+of ADP B-O
+cytokines NOUN B-O
+IL-1α PROPN B-AC
+, PUNCT B-O
+IL-1β PROPN B-AC
+, PUNCT B-O
+IL-6 PROPN B-AC
+and CCONJ B-O
+IL-10 PROPN B-AC
+in ADP B-O
+infants NOUN B-O
+with ADP B-O
+confirmed VERB B-O
+late ADJ B-LF
+- PUNCT I-LF
+onset NOUN I-LF
+sepsis NOUN I-LF
+( PUNCT B-O
+LOS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+possible ADJ B-O
+LOS PROPN B-AC
+and CCONJ B-O
+no DET B-O
+LOS PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+box NOUN B-O
+plots NOUN B-O
+show VERB B-O
+the DET B-O
+median ADJ B-O
+and CCONJ B-O
+interquartile ADJ B-O
+range NOUN B-O
+and CCONJ B-O
+statistically ADV B-O
+significant ADJ B-O
+differences NOUN B-O
+based VERB B-O
+on ADP B-O
+the DET B-O
+Mann PROPN B-O
+- PUNCT B-O
+Whitney PROPN B-O
+Test PROPN B-O
+( PUNCT B-O
+* PUNCT B-O
+, PUNCT B-O
+p<0.05 NUM B-O
+and CCONJ B-O
+* PUNCT B-O
+* PUNCT B-O
+, PUNCT B-O
+p<0.005 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+From ADP B-O
+a DET B-O
+societal ADJ B-O
+perspective NOUN B-O
+including VERB B-O
+informal ADJ B-O
+healthcare NOUN B-O
+costs NOUN B-O
+and CCONJ B-O
+lost VERB B-O
+productivity NOUN B-O
+, PUNCT B-O
+respective ADJ B-O
+ICERs PROPN B-AC
+were AUX B-O
+$ SYM B-O
+14,576 NUM B-O
+/ SYM B-O
+QALY PROPN B-AC
+and CCONJ B-O
+$ SYM B-O
+9,497 NUM B-O
+/ SYM B-O
+QALY PROPN B-AC
+. PUNCT B-O
+
+Results NOUN B-O
+were AUX B-O
+robust ADJ B-O
+in ADP B-O
+probabilistic ADJ B-O
+sensitivity NOUN B-O
+analyses NOUN B-O
+and CCONJ B-O
+a DET B-O
+range NOUN B-O
+of ADP B-O
+one NUM B-O
+- PUNCT B-O
+way NOUN B-O
+sensitivity NOUN B-O
+and CCONJ B-O
+subgroup NOUN B-O
+analyses NOUN B-O
+, PUNCT B-O
+including VERB B-O
+by ADP B-O
+different ADJ B-O
+durations NOUN B-O
+of ADP B-O
+the DET B-O
+intervention NOUN B-O
+( PUNCT B-O
+5 NUM B-O
+, PUNCT B-O
+10 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+20 NUM B-O
+years NOUN B-O
+and CCONJ B-O
+lifetime NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+food NOUN B-O
+subsidy NOUN B-O
+levels NOUN B-O
+( PUNCT B-O
+20 NUM B-O
+% PUNCT B-O
+, PUNCT B-O
+50 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+insurance NOUN B-O
+groups NOUN B-O
+( PUNCT B-O
+Medicare PROPN B-O
+, PUNCT B-O
+Medicaid PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+dual ADJ B-O
+- PUNCT B-O
+eligible ADJ B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+beneficiary NOUN B-O
+characteristics NOUN B-O
+within ADP B-O
+each DET B-O
+insurance NOUN B-O
+group NOUN B-O
+( PUNCT B-O
+age NOUN B-O
+, PUNCT B-O
+race NOUN B-O
+/ SYM B-O
+ethnicity NOUN B-O
+, PUNCT B-O
+education NOUN B-O
+, PUNCT B-O
+income NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+Supplemental PROPN B-LF
+Nutrition PROPN I-LF
+Assistant PROPN I-LF
+Program PROPN I-LF
+[ PUNCT B-O
+SNAP PROPN B-AC
+] PUNCT B-O
+status NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+t NOUN B-O
+: PUNCT B-O
+endoscopic ADJ B-LF
+papillary ADJ I-LF
+balloon NOUN I-LF
+dilatation NOUN I-LF
+duration NOUN B-O
+time NOUN B-O
+, PUNCT B-O
+N NOUN B-O
+: PUNCT B-O
+number NOUN B-O
+, PUNCT B-O
+BMI PROPN B-O
+: PUNCT B-O
+body NOUN B-O
+mass NOUN B-O
+index NOUN B-O
+, PUNCT B-O
+BW PROPN B-O
+: PUNCT B-O
+body NOUN B-O
+weight NOUN B-O
+, PUNCT B-O
+CV PROPN B-O
+: PUNCT B-O
+cardiovascular ADJ B-O
+, PUNCT B-O
+CM PROPN B-O
+: PUNCT B-O
+chest NOUN B-O
+, PUNCT B-O
+DM PROPN B-O
+: PUNCT B-O
+diabetes NOUN B-O
+mellitus NOUN B-O
+, PUNCT B-O
+SBP PROPN B-O
+: PUNCT B-O
+systolic ADJ B-O
+blood NOUN B-O
+pressure NOUN B-O
+, PUNCT B-O
+BT PROPN B-O
+: PUNCT B-O
+body NOUN B-O
+temperature NOUN B-O
+, PUNCT B-O
+HR NOUN B-O
+: PUNCT B-O
+heart NOUN B-O
+rate NOUN B-O
+, PUNCT B-O
+RR PROPN B-O
+: PUNCT B-O
+respiratory ADJ B-O
+rate NOUN B-O
+, PUNCT B-O
+WBC PROPN B-O
+: PUNCT B-O
+white ADJ B-O
+blood NOUN B-O
+cell NOUN B-O
+count NOUN B-O
+, PUNCT B-O
+Hb PROPN B-O
+: PUNCT B-O
+hemoglobin NOUN B-O
+, PUNCT B-O
+PLT PROPN B-O
+: PUNCT B-O
+platelet NOUN B-O
+, PUNCT B-O
+INR PROPN B-O
+: PUNCT B-O
+international ADJ B-O
+normalized VERB B-O
+ratio NOUN B-O
+, PUNCT B-O
+ALT PROPN B-O
+: PUNCT B-O
+alanine NOUN B-O
+aminotransferase NOUN B-O
+, PUNCT B-O
+AST PROPN B-O
+: PUNCT B-O
+aspartate NOUN B-O
+aminotransferase NOUN B-O
+, PUNCT B-O
+BUN PROPN B-O
+: PUNCT B-O
+blood NOUN B-O
+urea NOUN B-O
+nitrogen NOUN B-O
+, PUNCT B-O
+Cr PROPN B-O
+: PUNCT B-O
+creatinine NOUN B-O
+, PUNCT B-O
+ALP PROPN B-O
+: PUNCT B-O
+alkaline NOUN B-O
+phosphatase NOUN B-O
+, PUNCT B-O
+rGT PROPN B-O
+: PUNCT B-O
+gamma NOUN B-O
+- PUNCT B-O
+glutamyl NOUN B-O
+transpeptidase NOUN B-O
+, PUNCT B-O
+Amy PROPN B-O
+: PUNCT B-O
+amylase NOUN B-O
+, PUNCT B-O
+Tbili PROPN B-O
+: PUNCT B-O
+total NOUN B-O
+bilirubin NOUN B-O
+, PUNCT B-O
+CRP PROPN B-O
+: PUNCT B-O
+c NOUN B-O
+- PUNCT B-O
+reactive ADJ B-O
+protein NOUN B-O
+, PUNCT B-O
+BD PROPN B-O
+: PUNCT B-O
+bile NOUN B-O
+duct NOUN B-O
+, PUNCT B-O
+CBD PROPN B-AC
+: PUNCT B-O
+common ADJ B-LF
+bile NOUN I-LF
+duct NOUN I-LF
+, PUNCT B-O
+PTCD PROPN B-O
+: PUNCT B-O
+percutaneous ADJ B-O
+transhepatic ADJ B-O
+cholangiography NOUN B-O
+and CCONJ B-O
+drainage NOUN B-O
+, PUNCT B-O
+PTGBD PROPN B-O
+: PUNCT B-O
+percutaneous ADJ B-O
+transhepatic ADJ B-O
+gallbladder NOUN B-O
+drainage NOUN B-O
+, PUNCT B-O
+EST PROPN B-AC
+: PUNCT B-O
+endoscopic ADJ B-LF
+sphincterotomy NOUN I-LF
+, PUNCT B-O
+EPBD PROPN B-AC
+: PUNCT B-O
+endoscopic ADJ B-LF
+papillary ADJ I-LF
+balloon NOUN I-LF
+dilatation NOUN I-LF
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+we PRON B-O
+analyse VERB B-O
+a DET B-O
+newly ADV B-O
+created VERB B-O
+dataset NOUN B-O
+of ADP B-O
+trade NOUN B-O
+challenges NOUN B-O
+about ADP B-O
+food NOUN B-O
+, PUNCT B-O
+beverage NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+tobacco NOUN B-O
+regulations NOUN B-O
+among ADP B-O
+122 NUM B-O
+World PROPN B-LF
+Trade PROPN I-LF
+Organization PROPN I-LF
+( PUNCT B-O
+WTO PROPN B-AC
+) PUNCT B-O
+members NOUN B-O
+from ADP B-O
+January PROPN B-O
+1 NUM B-O
+, PUNCT B-O
+1995 NUM B-O
+to ADP B-O
+December PROPN B-O
+31 NUM B-O
+, PUNCT B-O
+2016 NUM B-O
+. PUNCT B-O
+
+Severe ADJ B-O
+abdominal ADJ B-LF
+aortic ADJ I-LF
+calcification NOUN I-LF
+( PUNCT B-O
+AAC PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+associated VERB B-O
+with ADP B-O
+higher ADJ B-O
+risk NOUN B-O
+of ADP B-O
+cardiovascular ADJ B-O
+event NOUN B-O
+and CCONJ B-O
+of ADP B-O
+fragility NOUN B-O
+fracture NOUN B-O
+. PUNCT B-O
+
+Oxidative ADJ B-O
+stress NOUN B-O
+results VERB B-O
+in ADP B-O
+the DET B-O
+generation NOUN B-O
+of ADP B-O
+excessive ADJ B-O
+reactive ADJ B-LF
+oxygen NOUN I-LF
+species NOUN I-LF
+( PUNCT B-O
+ROS PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+reactive ADJ B-LF
+nitrogen NOUN I-LF
+species NOUN I-LF
+( PUNCT B-O
+RNS PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+9–12 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+promotes VERB B-O
+the DET B-O
+formation NOUN B-O
+of ADP B-O
+lipid NOUN B-O
+peroxides NOUN B-O
+and CCONJ B-O
+damages VERB B-O
+the DET B-O
+RNA NOUN B-O
+, PUNCT B-O
+DNA PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+proteins NOUN B-O
+. PUNCT B-O
+
+Further ADV B-O
+, PUNCT B-O
+biological ADJ B-O
+samples NOUN B-O
+were AUX B-O
+often ADV B-O
+analyzed VERB B-O
+using VERB B-O
+nuclear ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+spectroscopy NOUN B-O
+( PUNCT B-O
+NMR PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+the DET B-O
+only ADJ B-O
+analytical ADJ B-O
+method NOUN B-O
+, PUNCT B-O
+data NOUN B-O
+analysis NOUN B-O
+was AUX B-O
+mainly ADV B-O
+based VERB B-O
+on ADP B-O
+principle ADJ B-O
+component NOUN B-O
+analysis NOUN B-O
+( PUNCT B-O
+PCA PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+partial ADJ B-LF
+least ADJ I-LF
+squares NOUN I-LF
+discriminant ADJ B-O
+analysis NOUN B-O
+( PUNCT B-O
+PLS PROPN B-AC
+- PUNCT B-O
+DA PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+thus ADV B-O
+results NOUN B-O
+have AUX B-O
+been AUX B-O
+rather ADV B-O
+descriptive ADJ B-O
+[ PUNCT B-O
+2 NUM B-O
+, PUNCT B-O
+5 NUM B-O
+, PUNCT B-O
+16 NUM B-O
+, PUNCT B-O
+18 NUM B-O
+, PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+UHDRS PROPN B-AC
+motor NOUN B-O
+score NOUN B-O
+( PUNCT B-O
+A NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+UHDRS PROPN B-AC
+behavioral ADJ B-O
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+IS PROPN B-AC
+: PUNCT B-O
+Independence PROPN B-O
+Score PROPN B-O
+( PUNCT B-O
+C PROPN B-O
+) PUNCT B-O
+; PUNCT B-O
+FAS PROPN B-AC
+: PUNCT B-O
+Functional PROPN B-LF
+Assessment PROPN I-LF
+Scale PROPN I-LF
+( PUNCT B-O
+D NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+cognitive ADJ B-O
+( PUNCT B-O
+letter NOUN B-O
+fluency NOUN B-O
+1 NUM B-O
+’ PUNCT B-O
+: PUNCT B-O
+at ADP B-O
+1 NUM B-O
+minute NOUN B-O
+( PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+letter NOUN B-O
+fluency NOUN B-O
+2 NUM B-O
+’ PUNCT B-O
+: PUNCT B-O
+at ADP B-O
+2 NUM B-O
+minutes NOUN B-O
+( PUNCT B-O
+F NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+SDMT PROPN B-AC
+: PUNCT B-O
+symbol NOUN B-O
+digit NOUN B-O
+modalities NOUN B-O
+test NOUN B-O
+( PUNCT B-O
+G NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+Stroop NOUN B-O
+C PROPN B-O
+: PUNCT B-O
+Stroop NOUN B-O
+color NOUN B-O
+( PUNCT B-O
+H NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+Stroop NOUN B-O
+W PROPN B-O
+: PUNCT B-O
+Stroop NOUN B-O
+word NOUN B-O
+( PUNCT B-O
+I NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+Stroop NOUN B-O
+W PROPN B-O
+/ SYM B-O
+C PROPN B-O
+: PUNCT B-O
+Stroop NOUN B-O
+interference NOUN B-O
+( PUNCT B-O
+J NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+RR PROPN B-AC
+, PUNCT B-O
+relative ADJ B-LF
+risk NOUN I-LF
+. PUNCT B-O
+
+Dpp PROPN B-AC
+, PUNCT B-O
+Decapentaplegic PROPN B-LF
+; PUNCT B-O
+GMR PROPN B-AC
+, PUNCT B-O
+glass NOUN B-LF
+multiple ADJ I-LF
+reporter NOUN I-LF
+; PUNCT B-O
+MF PROPN B-AC
+, PUNCT B-O
+morphogenetic ADJ B-LF
+furrow NOUN I-LF
+; PUNCT B-O
+rpr PROPN B-O
+, PUNCT B-O
+reaper NOUN B-O
+. PUNCT B-O
+
+Since SCONJ B-O
+a DET B-O
+down ADJ B-O
+- ADJ B-O
+stream NOUN B-O
+integrator NOUN B-O
+of ADP B-O
+metabolic ADJ B-O
+alterations NOUN B-O
+, PUNCT B-O
+mammalian ADJ B-LF
+target NOUN I-LF
+of ADP I-LF
+rapamycin NOUN I-LF
+( PUNCT B-O
+mTOR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+is AUX B-O
+responsible ADJ B-O
+for ADP B-O
+controlling VERB B-O
+the DET B-O
+balance NOUN B-O
+between ADP B-O
+pro ADJ B-O
+- ADJ B-O
+inflammatory ADJ B-O
+interleukin NOUN B-LF
+( PUNCT B-O
+IL)-12 PROPN B-AC
+and CCONJ B-O
+anti ADJ B-O
+- ADJ B-O
+inflammatory ADJ B-O
+IL-10 PROPN B-AC
+, PUNCT B-O
+we PRON B-O
+investigated VERB B-O
+the DET B-O
+effect NOUN B-O
+of ADP B-O
+upstream ADJ B-O
+interference NOUN B-O
+using VERB B-O
+metabolic ADJ B-O
+modulators NOUN B-O
+on ADP B-O
+the DET B-O
+production NOUN B-O
+of ADP B-O
+pro- ADJ B-O
+and CCONJ B-O
+anti ADJ B-O
+- ADJ B-O
+inflammatory ADJ B-O
+cytokines NOUN B-O
+. PUNCT B-O
+
+E NOUN B-O
+: PUNCT B-O
+Representative ADJ B-O
+images NOUN B-O
+of ADP B-O
+hepatic ADJ B-O
+hematoxylin NOUN B-O
+and CCONJ B-O
+eosin NOUN B-O
+( PUNCT B-O
+H&E PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+Oil PROPN B-O
+Red PROPN B-O
+O NOUN B-O
+and CCONJ B-O
+chloroacetate NOUN B-LF
+esterase NOUN I-LF
+( PUNCT B-O
+CAE PROPN B-AC
+) PUNCT B-O
+staining NOUN B-O
+. PUNCT B-O
+
+DOTS PROPN B-AC
+( PUNCT B-O
+directly ADV B-LF
+observed VERB I-LF
+treatment NOUN I-LF
+, PUNCT I-LF
+short ADJ I-LF
+course NOUN I-LF
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+internationally ADV B-O
+recommended VERB B-O
+control NOUN B-O
+strategy NOUN B-O
+for ADP B-O
+TB PROPN B-AC
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Logistic ADJ B-O
+regression NOUN B-O
+was AUX B-O
+used VERB B-O
+to ADP B-O
+estimate VERB B-O
+the DET B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT B-O
+OR PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-O
+interval NOUN B-O
+for ADP B-O
+the DET B-O
+relation NOUN B-O
+of ADP B-O
+diabetes NOUN B-O
+to ADP B-O
+the DET B-O
+IDE PROPN B-O
+genes NOUN B-O
+. PUNCT B-O
+
+Continuous ADJ B-O
+variables NOUN B-O
+with ADP B-O
+normal ADJ B-O
+distribution NOUN B-O
+are AUX B-O
+reported VERB B-O
+as ADP B-O
+mean NOUN B-O
+and CCONJ B-O
+standard ADJ B-O
+deviation NOUN B-O
+and CCONJ B-O
+compared VERB B-O
+using VERB B-O
+analysis NOUN B-LF
+of ADP I-LF
+variance NOUN I-LF
+( PUNCT B-O
+ANOVA PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Variables NOUN B-O
+without ADP B-O
+normal ADJ B-O
+distribution NOUN B-O
+are AUX B-O
+reported VERB B-O
+as ADP B-O
+median ADJ B-O
+and CCONJ B-O
+interquartile ADJ B-O
+range NOUN B-O
+( PUNCT B-O
+IQR PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+compared VERB B-O
+with ADP B-O
+Kruskal PROPN B-O
+- PUNCT B-O
+Wallis PROPN B-O
+test NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+contrast NOUN B-O
+, PUNCT B-O
+significant ADJ B-O
+progress NOUN B-O
+has AUX B-O
+been AUX B-O
+made VERB B-O
+in ADP B-O
+reconstituting VERB B-O
+purely ADV B-O
+chemical ADJ B-O
+reactions NOUN B-O
+that PRON B-O
+self NOUN B-O
+- PUNCT B-O
+organise VERB B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+the DET B-O
+Belousov PROPN B-O
+- PUNCT B-O
+Zhabotinski PROPN B-O
+reactions NOUN B-O
+[ PUNCT B-O
+13,14,15 NUM B-O
+] PUNCT B-O
+and CCONJ B-O
+Turing PROPN B-O
+- PUNCT B-O
+type NOUN B-O
+, PUNCT B-O
+Meinhardt PROPN B-LF
+- PUNCT I-LF
+Gierer PROPN I-LF
+( PUNCT B-O
+M-G PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+oscillatory ADJ B-O
+reactions NOUN B-O
+[ PUNCT B-O
+16,17,18,19,20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+CI PROPN B-AC
+, PUNCT B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT B-O
+HR PROPN B-AC
+, PUNCT B-O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+Ref PROPN B-O
+. PUNCT B-O
+
+, PUNCT B-O
+Reference PROPN B-O
+category NOUN B-O
+We PRON B-O
+therefore ADV B-O
+aimed VERB B-O
+at ADV B-O
+exploring VERB B-O
+the DET B-O
+repertoire NOUN B-O
+of ADP B-O
+mRNAs NOUN B-O
+bound VERB B-O
+by ADP B-O
+aaRSs PROPN B-AC
+. PUNCT B-O
+
+To ADP B-O
+this DET B-O
+end NOUN B-O
+, PUNCT B-O
+we PRON B-O
+utilized VERB B-O
+yeast NOUN B-O
+strains NOUN B-O
+expressing VERB B-O
+endogenously ADV B-O
+, PUNCT B-O
+C PROPN B-O
+- PUNCT B-O
+terminally ADV B-O
+Tandem PROPN B-LF
+Affinity PROPN I-LF
+Purification PROPN I-LF
+( PUNCT B-O
+methionyl NOUN B-LF
+TAP)-tagged PROPN B-AC
+- PUNCT I-LF
+tRNA NOUN I-LF
+synthetase NOUN I-LF
+( PUNCT B-O
+MetRS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+glutamyl NOUN B-LF
+- PUNCT I-LF
+tRNA NOUN I-LF
+synthetase NOUN I-LF
+( PUNCT B-O
+GluRS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+valyl NOUN B-LF
+- PUNCT I-LF
+tRNA NOUN I-LF
+synthetase NOUN I-LF
+( PUNCT B-O
+ValRS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+HisRS PROPN B-AC
+or CCONJ B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+GFP)-tagged PROPN B-AC
+HisRS PROPN B-AC
+and CCONJ B-O
+glutamine NOUN B-LF
+- PUNCT I-LF
+tRNA NOUN I-LF
+synthetase NOUN I-LF
+( PUNCT B-O
+GlnRS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+These DET B-O
+aaRSs PROPN B-AC
+appeared VERB B-O
+to PART B-O
+be AUX B-O
+associated VERB B-O
+with ADP B-O
+mRNA NOUN B-O
+in ADP B-O
+at ADV B-O
+least ADV B-O
+two NUM B-O
+of ADP B-O
+the DET B-O
+yeast NOUN B-O
+interactome NOUN B-O
+studies NOUN B-O
+( PUNCT B-O
+S1 PROPN B-O
+Table PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+contrast NOUN B-O
+to ADP B-O
+other ADJ B-O
+XP PROPN B-AC
+patients NOUN B-O
+, PUNCT B-O
+those PRON B-O
+with ADP B-O
+the DET B-O
+variant NOUN B-O
+form NOUN B-O
+( PUNCT B-O
+XPV PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+Xeroderma PROPN B-LF
+Pigmentosum PROPN I-LF
+have VERB B-O
+no DET B-O
+defect NOUN B-O
+in ADP B-O
+excision NOUN B-O
+repair NOUN B-O
+[ PUNCT B-O
+8 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+but CCONJ B-O
+are AUX B-O
+deficient ADJ B-O
+in ADP B-O
+post ADJ B-O
+- ADJ B-O
+replication ADJ B-O
+repair NOUN B-O
+[ PUNCT B-O
+23 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Then ADV B-O
+, PUNCT B-O
+we PRON B-O
+selected VERB B-O
+the DET B-O
+compounds NOUN B-O
+library NOUN B-O
+which PRON B-O
+included VERB B-O
+those DET B-O
+drug NOUN B-O
+classes NOUN B-O
+( PUNCT B-O
+ZINC15 PROPN B-O
+FDA PROPN B-O
+- PUNCT B-O
+approved VERB B-O
+drugs NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+carried VERB B-O
+out ADP B-O
+the DET B-O
+virtual ADJ B-LF
+screening NOUN I-LF
+( PUNCT B-O
+VS PROPN B-AC
+) PUNCT B-O
+study NOUN B-O
+against ADP B-O
+that DET B-O
+library NOUN B-O
+using VERB B-O
+structures NOUN B-O
+of ADP B-O
+incretin NOUN B-O
+receptors NOUN B-O
+. PUNCT B-O
+
+Analytical ADJ B-LF
+ultracentrifugation NOUN I-LF
+( PUNCT B-O
+AUC PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+sedimentation NOUN B-LF
+velocity NOUN I-LF
+( PUNCT B-O
+SV PROPN B-AC
+) PUNCT B-O
+mode NOUN B-O
+was AUX B-O
+performed VERB B-O
+on ADP B-O
+the DET B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+protein NOUN B-O
+and CCONJ B-O
+all PRON B-O
+of ADP B-O
+the DET B-O
+mutated VERB B-O
+proteins NOUN B-O
+. PUNCT B-O
+
+Virus NOUN B-O
+titers NOUN B-O
+were AUX B-O
+determined VERB B-O
+by ADP B-O
+endpoint NOUN B-O
+dilution NOUN B-O
+assay NOUN B-O
+and CCONJ B-O
+calculated VERB B-O
+by ADP B-O
+the DET B-O
+method NOUN B-O
+of ADP B-O
+Reed PROPN B-O
+and CCONJ B-O
+Muench PROPN B-O
+and CCONJ B-O
+expressed VERB B-O
+as ADP B-O
+50 NUM B-LF
+% NOUN I-LF
+tissue NOUN I-LF
+culture NOUN I-LF
+infectious ADJ I-LF
+dose NOUN I-LF
+( PUNCT B-O
+TCID50 PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+53 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Examples NOUN B-O
+include VERB B-O
+statine NOUN B-LF
+( PUNCT B-O
+Sta)-containing PROPN B-AC
+inhibitors NOUN B-O
+and CCONJ B-O
+several ADJ B-O
+are AUX B-O
+now ADV B-O
+in ADP B-O
+clinical ADJ B-O
+use NOUN B-O
+[ PUNCT B-O
+21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Consistently ADV B-O
+, PUNCT B-O
+in ADP B-O
+pollen NOUN B-O
+tubes NOUN B-O
+tip NOUN B-O
+, PUNCT B-O
+ROP PROPN B-AC
+/ SYM B-O
+RAC PROPN B-O
+proteins NOUN B-O
+were AUX B-O
+shown VERB B-O
+to PART B-O
+physically ADV B-O
+associate VERB B-O
+with ADP B-O
+a DET B-O
+phosphatidylinositol NOUN B-LF
+monophosphate NOUN I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+PtdInsP-K PROPN B-AC
+) PUNCT B-O
+activity NOUN B-O
+[ PUNCT B-O
+46 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+PtdIns PROPN B-O
+- PUNCT B-O
+P2 PROPN B-O
+, PUNCT B-O
+the DET B-O
+product NOUN B-O
+of ADP B-O
+PtdIns PROPN B-AC
+, PUNCT B-O
+had VERB B-O
+similar ADJ B-O
+distribution NOUN B-O
+[ PUNCT B-O
+46],[47 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+FLPe PROPN B-O
+( PUNCT B-O
+Flip)-mediated NOUN B-O
+recombination NOUN B-O
+resulted VERB B-O
+in ADP B-O
+a DET B-O
+continuous ADJ B-O
+reading NOUN B-O
+frame NOUN B-O
+from ADP B-O
+the DET B-O
+authentic ADJ B-O
+Mll2 NOUN B-O
+initiating VERB B-O
+codon NOUN B-O
+, PUNCT B-O
+through ADP B-O
+eYFP NOUN B-O
+and CCONJ B-O
+the DET B-O
+residual ADJ B-O
+FRT NOUN B-O
+to PART B-O
+the DET B-O
+second ADJ B-O
+amino NOUN B-O
+acid NOUN B-O
+of ADP B-O
+Mll2 NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+Mice NOUN B-O
+carrying VERB B-O
+a DET B-O
+single ADJ B-O
+copy NOUN B-O
+of ADP B-O
+Mll2 NOUN B-O
+tm2 NOUN B-O
+( PUNCT B-O
+Mll2 NOUN B-O
+tm2/+ NOUN B-O
+) PUNCT B-O
+were AUX B-O
+intercrossed VERB B-O
+to PART B-O
+obtain VERB B-O
+control NOUN B-O
+( PUNCT B-O
+Mll2 NOUN B-O
++ X B-O
+/+and CCONJ B-O
+Mll2 NOUN B-O
+tm2/+ NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+experimental ADJ B-O
+Mll2 NOUN B-O
+tm2 NOUN B-O
+/ SYM B-O
+tm2 NOUN B-O
+mice NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+C X B-O
+) PUNCT B-O
+Southern PROPN B-O
+blot NOUN B-O
+analysis NOUN B-O
+of ADP B-O
+tail NOUN B-O
+genomic ADJ B-O
+DNA NOUN B-O
+: PUNCT B-O
+a DET B-O
+3.8 NUM B-O
+kb NOUN B-O
+band NOUN B-O
+denotes VERB B-O
+the DET B-O
+Mll2 NOUN B-O
+tm2 NOUN B-O
+/ SYM B-O
+tm2 NOUN B-O
+allele NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+a DET B-O
+3.0 NUM B-O
+kb NOUN B-O
+band NOUN B-O
+denotes VERB B-O
+the DET B-O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT B-O
+WT PROPN B-AC
+) PUNCT B-O
+allele NOUN B-O
+. PUNCT B-O
+
+Fewer ADJ B-O
+falls NOUN B-O
+( PUNCT B-O
+incidence NOUN B-LF
+rate NOUN I-LF
+ratio NOUN I-LF
+[ PUNCT B-O
+IRR PROPN B-AC
+] PUNCT B-O
+: PUNCT B-O
+0.65 NUM B-O
+, PUNCT B-O
+0.43–0.99 NUM B-O
+; PUNCT B-O
+P NOUN B-O
+= SYM B-O
+0.042 NUM B-O
+) PUNCT B-O
+were AUX B-O
+observed VERB B-O
+in ADP B-O
+the DET B-O
+RESPOND NOUN B-O
+group NOUN B-O
+compared VERB B-O
+with ADP B-O
+the DET B-O
+control NOUN B-O
+( PUNCT B-O
+Table PROPN B-O
+3 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Cancer NOUN B-O
+development NOUN B-O
+and CCONJ B-O
+tumor NOUN B-O
+growth NOUN B-O
+are AUX B-O
+driven VERB B-O
+by ADP B-O
+specific ADJ B-O
+types NOUN B-O
+of ADP B-O
+cells NOUN B-O
+— PUNCT B-O
+stem NOUN B-LF
+cell NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+cancer NOUN I-LF
+cells NOUN I-LF
+( PUNCT B-O
+SCLCCs)—which PROPN B-AC
+are AUX B-O
+also ADV B-O
+responsible ADJ B-O
+for ADP B-O
+metastatic ADJ B-O
+spread NOUN B-O
+and CCONJ B-O
+drug NOUN B-O
+resistance NOUN B-O
+. PUNCT B-O
+
+Under ADP B-O
+some DET B-O
+conditions NOUN B-O
+, PUNCT B-O
+the DET B-O
+C262 PROPN B-O
+- PUNCT B-O
+S PROPN B-AC
+P NOUN B-O
+ribozyme NOUN B-LF
+E·S·G PROPN B-AC
+ternary ADJ B-O
+complex NOUN B-O
+must AUX B-O
+undergo VERB B-O
+a DET B-O
+rate NOUN B-O
+- PUNCT B-O
+limiting VERB B-O
+conformational ADJ B-O
+change NOUN B-O
+en ADP B-O
+route NOUN B-O
+to ADP B-O
+the DET B-O
+chemical ADJ B-O
+transition NOUN B-O
+state NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+address VERB B-O
+these DET B-O
+concerns NOUN B-O
+, PUNCT B-O
+we PRON B-O
+propose VERB B-O
+a DET B-O
+new ADJ B-O
+generic ADJ B-O
+approach NOUN B-O
+for ADP B-O
+estimating VERB B-O
+the DET B-O
+distribution NOUN B-O
+of ADP B-O
+incident NOUN B-O
+infections NOUN B-O
+acquired VERB B-O
+according VERB B-O
+to PART B-O
+identifiable ADJ B-O
+determinants NOUN B-O
+of ADP B-O
+risk NOUN B-O
+in ADP B-O
+the DET B-O
+generalised VERB B-O
+epidemics NOUN B-O
+of ADP B-O
+SSA PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+objectives NOUN B-O
+of ADP B-O
+this DET B-O
+study NOUN B-O
+were AUX B-O
+to PART B-O
+( PUNCT B-O
+1 X B-O
+) PUNCT B-O
+describe VERB B-O
+the DET B-O
+Incidence PROPN B-LF
+Patterns PROPN I-LF
+Model PROPN I-LF
+( PUNCT B-O
+IPM PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+SSA PROPN B-AC
+, PUNCT B-O
+( PUNCT B-O
+2 X B-O
+) PUNCT B-O
+validate VERB B-O
+and CCONJ B-O
+train VERB B-O
+the DET B-O
+IPM PROPN B-AC
+using VERB B-O
+data NOUN B-O
+from ADP B-O
+cohort NOUN B-O
+studies NOUN B-O
+in ADP B-O
+four NUM B-O
+countries NOUN B-O
+, PUNCT B-O
+( PUNCT B-O
+3 X B-O
+) PUNCT B-O
+apply VERB B-O
+the DET B-O
+IPM PROPN B-AC
+to PART B-O
+six NUM B-O
+different ADJ B-O
+countries NOUN B-O
+to PART B-O
+show VERB B-O
+the DET B-O
+predicted VERB B-O
+distributions NOUN B-O
+of ADP B-O
+newly ADV B-O
+acquired VERB B-O
+HIV PROPN B-O
+infections NOUN B-O
+in ADP B-O
+different ADJ B-O
+population NOUN B-O
+groups NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+( PUNCT B-O
+4 X B-O
+) PUNCT B-O
+use VERB B-O
+the DET B-O
+IPM PROPN B-AC
+outputs NOUN B-O
+to PART B-O
+infer VERB B-O
+the DET B-O
+distributions NOUN B-O
+of ADP B-O
+the DET B-O
+groups NOUN B-O
+transmitting VERB B-O
+HIV PROPN B-O
+. PUNCT B-O
+
+The DET B-O
+accumulation NOUN B-O
+of ADP B-O
+TAG PROPN B-AC
+- PUNCT B-O
+containing VERB B-O
+lipid NOUN B-O
+droplets NOUN B-O
+in ADP B-O
+multiple ADJ B-O
+tissues NOUN B-O
+characteristic ADJ B-O
+of ADP B-O
+CDS PROPN B-O
+has AUX B-O
+been AUX B-O
+linked VERB B-O
+to ADP B-O
+impaired ADJ B-O
+lipolysis NOUN B-O
+caused VERB B-O
+by ADP B-O
+mutations NOUN B-O
+in ADP B-O
+comparative ADJ B-LF
+gene NOUN I-LF
+identification NOUN I-LF
+58 NUM I-LF
+( PUNCT B-O
+CGI-58 PROPN B-AC
+; PUNCT B-O
+also ADV B-O
+called VERB B-O
+ABHD5 NOUN B-O
+) PUNCT B-O
+[ PUNCT B-O
+5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Hepatorenal PROPN B-LF
+syndrome NOUN I-LF
+( PUNCT B-O
+HRS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+most ADV B-O
+severe ADJ B-O
+form NOUN B-O
+of ADP B-O
+AKI PROPN B-AC
+in ADP B-O
+cirrhosis NOUN B-O
+, PUNCT B-O
+develops VERB B-O
+in ADP B-O
+more ADJ B-O
+than ADP B-O
+50 NUM B-O
+% NOUN B-O
+of ADP B-O
+patients NOUN B-O
+with ADP B-O
+cirrhosis NOUN B-O
+who PRON B-O
+die VERB B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+PCA PROPN B-AC
+, PUNCT B-O
+principal ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+. PUNCT B-O
+
+BHIS PROPN B-AC
+, PUNCT B-O
+brain NOUN B-LF
+heart NOUN I-LF
+infusion NOUN I-LF
+plus CCONJ I-LF
+yeast NOUN I-LF
+; PUNCT B-O
+c PROPN B-AC
+, PUNCT B-O
+cyclic ADJ B-LF
+diguanosine NOUN I-LF
+monophosphate NOUN I-LF
+; PUNCT B-O
+cmr NOUN B-O
+, PUNCT B-O
+colony NOUN B-O
+morphology NOUN B-O
+regulators NOUN B-O
+; PUNCT B-O
+-di-GMPDccA PROPN B-AC
+, PUNCT B-O
+diguanylate NOUN B-LF
+cyclase NOUN I-LF
+A NOUN I-LF
+; PUNCT B-O
+erm PROPN B-AC
+, PUNCT B-O
+erythromycin NOUN B-LF
+resistance NOUN I-LF
+cassette NOUN I-LF
+; PUNCT B-O
+mut NOUN B-O
+, PUNCT B-O
+mutant NOUN B-O
+; PUNCT B-O
+R NOUN B-O
+, PUNCT B-O
+rough ADJ B-O
+; PUNCT B-O
+S NOUN B-O
+, PUNCT B-O
+smooth NOUN B-O
+; PUNCT B-O
+qPCR PROPN B-AC
+, PUNCT B-O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+; PUNCT B-O
+qRT PROPN B-AC
+, PUNCT B-O
+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+PCR NOUN I-LF
+; PUNCT B-O
+sigD NOUN B-O
+, PUNCT B-O
+sigma NOUN B-O
+factor NOUN B-O
+D PROPN B-O
+gene NOUN B-O
+; PUNCT B-O
+-PCRTFP PROPN B-AC
+, PUNCT B-O
+type NOUN B-LF
+IV NUM I-LF
+pilus NOUN I-LF
+. PUNCT B-O
+
+Interferon PROPN B-LF
+( PUNCT B-O
+IFN PROPN B-AC
+) PUNCT B-O
+therapy NOUN B-O
+has AUX B-O
+been AUX B-O
+proved VERB B-O
+to PART B-O
+achieve VERB B-O
+sustained ADJ B-LF
+virologic ADJ I-LF
+response NOUN I-LF
+( PUNCT B-O
+SVR PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+patients NOUN B-O
+with ADP B-O
+chronic ADJ B-O
+HCV PROPN B-AC
+infection NOUN B-O
+and CCONJ B-O
+can AUX B-O
+prevent VERB B-O
+progression NOUN B-O
+of ADP B-O
+liver NOUN B-O
+fibrosis NOUN B-O
+. PUNCT B-O
+
+Thus ADV B-O
+, PUNCT B-O
+we PRON B-O
+expressed VERB B-O
+carnitine NOUN B-O
+palmitoyltransferase NOUN B-O
+1AM PROPN B-O
+( PUNCT B-O
+CPT1AM PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+permanently ADV B-LF
+active ADJ I-LF
+mutant ADJ I-LF
+form NOUN I-LF
+of ADP I-LF
+CPT1A PROPN I-LF
+CPT1A PROPN B-AC
+( PUNCT B-O
+the DET B-O
+rate NOUN B-O
+- PUNCT B-O
+limiting VERB B-O
+enzyme NOUN B-O
+in ADP B-O
+FAO PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+a DET B-O
+rat NOUN B-O
+brown ADJ B-O
+adipocyte NOUN B-O
+( PUNCT B-O
+rBA PROPN B-AC
+) PUNCT B-O
+cell NOUN B-O
+line NOUN B-O
+through ADP B-O
+adenoviral ADJ B-O
+infection NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+neurons NOUN B-O
+, PUNCT B-O
+the DET B-O
+gp120 PROPN B-O
+interaction NOUN B-O
+with ADP B-O
+CXCR4 PROPN B-AC
+enhances VERB B-O
+Ca2 NOUN B-O
++ NOUN B-O
+-regulating VERB B-O
+systems NOUN B-O
+through ADP B-O
+NMDA PROPN B-O
+receptors NOUN B-O
+( PUNCT B-O
+NMDARs PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+synaptic ADJ B-O
+membrane NOUN B-O
+and CCONJ B-O
+inositol NOUN B-O
+trisphosphate NOUN B-O
+receptors NOUN B-O
+( PUNCT B-O
+IP3Rs PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT B-O
+ER PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+resulting VERB B-O
+in ADP B-O
+apoptosis NOUN B-O
+[ PUNCT B-O
+28–34 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Brain NOUN B-LF
+– PUNCT I-LF
+machine NOUN I-LF
+interfaces NOUN I-LF
+( PUNCT B-O
+BMIs PROPN B-AC
+) PUNCT B-O
+have VERB B-O
+the DET B-O
+potential NOUN B-O
+to PART B-O
+revolutionize VERB B-O
+the DET B-O
+care NOUN B-O
+of ADP B-O
+neurologically ADV B-O
+impaired ADJ B-O
+patients NOUN B-O
+. PUNCT B-O
+
+Antimicrobial ADJ B-LF
+peptides NOUN I-LF
+( PUNCT B-O
+AMPs PROPN B-AC
+) PUNCT B-O
+play VERB B-O
+a DET B-O
+key ADJ B-O
+role NOUN B-O
+in ADP B-O
+innate ADJ B-O
+immune ADJ B-O
+response NOUN B-O
+against ADP B-O
+bacteria NOUN B-O
+, PUNCT B-O
+viruses NOUN B-O
+, PUNCT B-O
+fungi NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+parasites NOUN B-O
+[ PUNCT B-O
+20,21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+FFR PROPN B-AC
+, PUNCT B-O
+fractional ADJ B-LF
+flow NOUN I-LF
+reserve NOUN I-LF
+. PUNCT B-O
+
+Co ADJ B-O
+- PUNCT B-O
+primary ADJ B-O
+short- ADJ B-O
+and CCONJ B-O
+long ADJ B-O
+- PUNCT B-O
+term NOUN B-O
+outcomes NOUN B-O
+were AUX B-O
+1 NUM B-O
+- PUNCT B-O
+year NOUN B-O
+total ADJ B-LF
+kidney NOUN I-LF
+volume NOUN I-LF
+( PUNCT B-O
+TKV PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+computed ADJ B-O
+tomography NOUN B-O
+scan NOUN B-O
+) PUNCT B-O
+growth NOUN B-O
+and CCONJ B-O
+3 NUM B-O
+- PUNCT B-O
+year NOUN B-O
+GFR PROPN B-AC
+( PUNCT B-O
+iohexol NOUN B-O
+plasma NOUN B-O
+clearance NOUN B-O
+) PUNCT B-O
+decline NOUN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+HEI PROPN B-AC
+, PUNCT B-O
+Healthy PROPN B-LF
+Eating PROPN I-LF
+Index PROPN I-LF
+; PUNCT B-O
+Q NOUN B-O
+, PUNCT B-O
+quartile NOUN B-O
+. PUNCT B-O
+
+Indeed ADV B-O
+, PUNCT B-O
+discrimination NOUN B-O
+of ADP B-O
+the DET B-O
+mother NOUN B-O
+and CCONJ B-O
+daughter NOUN B-O
+using VERB B-O
+CEP164 PROPN B-O
+immunostaining NOUN B-O
+showed VERB B-O
+that SCONJ B-O
+roots NOUN B-O
+are AUX B-O
+nucleated VERB B-O
+symmetrically ADV B-O
+on ADP B-O
+both CCONJ B-O
+mother NOUN B-O
+and CCONJ B-O
+daughter NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+4B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+similar ADJ B-O
+comparison NOUN B-O
+of ADP B-O
+PCM PROPN B-AC
+structure NOUN B-O
+with ADP B-O
+the DET B-O
+PCM PROPN B-AC
+resident NOUN B-O
+Pericentrin PROPN B-LF
+( PUNCT B-O
+PCNT PROPN B-AC
+) PUNCT B-O
+showed VERB B-O
+similarly ADV B-O
+that SCONJ B-O
+both CCONJ B-O
+mother NOUN B-O
+and CCONJ B-O
+daughter NOUN B-O
+centrioles NOUN B-O
+individually ADV B-O
+nucleate VERB B-O
+PCM PROPN B-AC
+when SCONJ B-O
+split VERB B-O
+( PUNCT B-O
+Fig NOUN B-O
+4C NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+something PRON B-O
+also ADV B-O
+evident ADJ B-O
+in ADP B-O
+the DET B-O
+live ADJ B-O
+- PUNCT B-O
+cell NOUN B-O
+imaging NOUN B-O
+of ADP B-O
+NEDD1 PROPN B-AC
+- PUNCT B-O
+mRuby3 PROPN B-O
+( PUNCT B-O
+Fig NOUN B-O
+3H–3 NUM B-O
+K NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+previous ADJ B-O
+work NOUN B-O
+[ X B-O
+24,32,34 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Water NOUN B-O
+deficit NOUN B-O
+was AUX B-O
+initiated VERB B-O
+when SCONJ B-O
+seedlings NOUN B-O
+were AUX B-O
+almost ADV B-O
+20 NUM B-O
+day NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+, PUNCT B-O
+attaining VERB B-O
+2–3 NUM B-O
+true ADJ B-O
+leaves NOUN B-O
+and CCONJ B-O
+it PRON B-O
+was AUX B-O
+applied VERB B-O
+by ADP B-O
+maintaining VERB B-O
+the DET B-O
+soil NOUN B-O
+moisture NOUN B-O
+at ADP B-O
+40 NUM B-O
+% NOUN B-O
+of ADP B-O
+substrate NOUN B-O
+field NOUN B-LF
+capacity NOUN I-LF
+( PUNCT B-O
+FC PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+the DET B-O
+stressed VERB B-O
+plants NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+80 NUM B-O
+% NOUN B-O
+FC PROPN B-AC
+for ADP B-O
+the DET B-O
+well ADV B-O
+- PUNCT B-O
+watered VERB B-O
+plants NOUN B-O
+. PUNCT B-O
+
+It PRON B-O
+would AUX B-O
+be AUX B-O
+worth ADJ B-O
+noting VERB B-O
+that PRON B-O
+the DET B-O
+clustered VERB B-O
+lysine NOUN B-O
+residues NOUN B-O
+that PRON B-O
+we PRON B-O
+found VERB B-O
+as ADP B-O
+TMP195 NOUN B-O
+- ADJ B-O
+sensitive ADJ B-O
+acetylation NOUN B-O
+sites NOUN B-O
+were AUX B-O
+located VERB B-O
+in ADP B-O
+the DET B-O
+N NOUN B-O
+- ADJ B-O
+terminal ADJ B-O
+intrinsically ADV B-LF
+disordered VERB I-LF
+region NOUN I-LF
+( PUNCT B-O
+IDR PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+NCL PROPN B-AC
+( PUNCT B-O
+S7C PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+[ PUNCT B-O
+87 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+They PRON B-O
+recognize VERB B-O
+bacterial ADJ B-O
+surface NOUN B-O
+molecules NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+lipopolysaccharides NOUN B-O
+( PUNCT B-O
+LPS PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+the DET B-O
+outer ADJ B-O
+wall NOUN B-O
+of ADP B-O
+Gram NOUN B-O
+- PUNCT B-O
+negative ADJ B-O
+bacteria NOUN B-O
+and CCONJ B-O
+flagellin NOUN B-LF
+( PUNCT B-O
+FLG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+a DET B-O
+structural ADJ B-O
+protein NOUN B-O
+of ADP B-O
+flagellum NOUN B-O
+, PUNCT B-O
+a DET B-O
+bacterial ADJ B-O
+locomotive NOUN B-O
+organelle NOUN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+OR PROPN B-AC
+: PUNCT B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+CI PROPN B-AC
+: PUNCT B-O
+confidence NOUN B-O
+interval NOUN B-O
+. PUNCT B-O
+
+MOI PROPN B-AC
+represents VERB B-O
+the DET B-O
+multiplicity NOUN B-LF
+of ADP I-LF
+infection NOUN I-LF
+. PUNCT B-O
+
+Both DET B-O
+domains NOUN B-O
+share VERB B-O
+approximately ADV B-O
+9 NUM B-O
+% NOUN B-O
+sequence NOUN B-O
+identity NOUN B-O
+and CCONJ B-O
+can AUX B-O
+be AUX B-O
+superimposed VERB B-O
+with ADP B-O
+a DET B-O
+root NOUN B-LF
+mean ADJ I-LF
+square ADJ I-LF
+( PUNCT B-O
+rms PROPN B-AC
+) PUNCT B-O
+deviation NOUN B-O
+of ADP B-O
+2.4 NUM B-O
+Å NOUN B-O
+using VERB B-O
+101 NUM B-O
+Cα NOUN B-O
+- NOUN B-O
+atoms NOUN B-O
+out ADP B-O
+of ADP B-O
+153 NUM B-O
+from ADP B-O
+domain NOUN B-O
+1 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+201 NUM B-O
+from ADP B-O
+domain NOUN B-O
+4 NUM B-O
+, PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+The DET B-O
+study NOUN B-O
+was AUX B-O
+carried VERB B-O
+out ADP B-O
+in ADP B-O
+collaboration NOUN B-O
+with ADP B-O
+the DET B-O
+Swiss PROPN B-LF
+Childhood PROPN I-LF
+Cancer PROPN I-LF
+Registry PROPN I-LF
+( PUNCT B-O
+SCCR PROPN B-AC
+, PUNCT B-O
+www.childhoodcancerregistry.ch X B-O
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+, PUNCT B-O
+since SCONJ B-O
+1976 NUM B-O
+, PUNCT B-O
+has AUX B-O
+included VERB B-O
+all DET B-O
+children NOUN B-O
+and CCONJ B-O
+adolescents NOUN B-O
+in ADP B-O
+Switzerland PROPN B-O
+diagnosed VERB B-O
+with ADP B-O
+leukemia NOUN B-O
+, PUNCT B-O
+lymphoma NOUN B-O
+, PUNCT B-O
+central ADJ B-LF
+nervous ADJ I-LF
+system NOUN I-LF
+( PUNCT B-O
+CNS PROPN B-AC
+) PUNCT B-O
+tumors NOUN B-O
+, PUNCT B-O
+malignant ADJ B-O
+solid ADJ B-O
+tumors NOUN B-O
+and CCONJ B-O
+Langerhans PROPN B-LF
+cell NOUN I-LF
+histiocytosis NOUN I-LF
+( PUNCT B-O
+LCH PROPN B-AC
+) PUNCT B-O
+before SCONJ B-O
+they PRON B-O
+were AUX B-O
+21 NUM B-O
+[ PUNCT B-O
+17 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Yunnan PROPN B-O
+province NOUN B-O
+itself PRON B-O
+has VERB B-O
+a DET B-O
+large ADJ B-O
+population NOUN B-O
+of ADP B-O
+people NOUN B-LF
+who PRON I-LF
+inject VERB I-LF
+drugs NOUN I-LF
+( PUNCT B-O
+PWID PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+15 NUM B-O
+, PUNCT B-O
+16 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+possibly ADV B-O
+due ADP B-O
+to ADP B-O
+Yunnan PROPN B-O
+’s PART B-O
+position NOUN B-O
+along ADP B-O
+key ADJ B-O
+heroin NOUN B-O
+trafficking NOUN B-O
+routes NOUN B-O
+into ADP B-O
+China PROPN B-O
+[ PUNCT B-O
+17 NUM B-O
+, PUNCT B-O
+18 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+A3A PROPN B-AC
+, PUNCT B-O
+APOBEC3A. PROPN B-LF
+Serial ADJ B-O
+10 NUM B-O
+- PUNCT B-O
+fold ADJ B-O
+dilution NOUN B-O
+from ADP B-O
+indicated VERB B-O
+strains NOUN B-O
+spotted VERB B-O
+onto ADP B-O
+media NOUN B-O
+containing VERB B-O
+indicated VERB B-O
+hydroxyurea NOUN B-LF
+( PUNCT B-O
+HU PROPN B-AC
+, PUNCT B-O
+top ADJ B-O
+panel NOUN B-O
+) PUNCT B-O
+or CCONJ B-O
+camptothecin NOUN B-LF
+( PUNCT B-O
+CPT PROPN B-AC
+, PUNCT B-O
+bottom ADJ B-O
+panel NOUN B-O
+) PUNCT B-O
+concentration NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+complete ADJ B-O
+results NOUN B-O
+for ADP B-O
+two NUM B-O
+distinct ADJ B-O
+diplococci NOUN B-O
+( PUNCT B-O
+no NOUN B-O
+. PUNCT B-O
+
+109 NUM B-O
+and CCONJ B-O
+no NOUN B-O
+. PUNCT B-O
+
+110 NUM B-O
+) PUNCT B-O
+are AUX B-O
+presented VERB B-O
+in ADP B-O
+Figure PROPN B-O
+S3 NUM B-O
+. PUNCT B-O
+
+The DET B-O
+position NOUN B-O
+coordinates NOUN B-O
+of ADP B-O
+individual ADJ B-O
+diplococci NOUN B-O
+mounted VERB B-O
+on ADP B-O
+formvar NOUN B-O
+- NOUN B-O
+coated VERB B-O
+gold NOUN B-O
+TEM PROPN B-AC
+grids NOUN B-O
+were AUX B-O
+determined VERB B-O
+by ADP B-O
+light NOUN B-LF
+microscopy NOUN I-LF
+( PUNCT B-O
+LM PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+TEM PROPN B-AC
+grids NOUN B-O
+were AUX B-O
+subsequently ADV B-O
+placed VERB B-O
+in ADP B-O
+the DET B-O
+focal ADJ B-O
+plane NOUN B-O
+of ADP B-O
+the DET B-O
+X NOUN B-O
+- NOUN B-O
+ray NOUN B-O
+optic NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+grid NOUN B-O
+markers NOUN B-O
+were AUX B-O
+used VERB B-O
+to PART B-O
+locate VERB B-O
+the DET B-O
+targeted VERB B-O
+cells NOUN B-O
+. PUNCT B-O
+
+Because SCONJ B-O
+PMNs PROPN B-AC
+adhere VERB B-O
+to ADP B-O
+plates NOUN B-O
+after ADP B-O
+activation NOUN B-O
+, PUNCT B-O
+the DET B-O
+use NOUN B-O
+of ADP B-O
+counting NOUN B-O
+by ADP B-O
+flow NOUN B-O
+cytometry NOUN B-O
+was AUX B-O
+ineffective ADJ B-O
+for ADP B-O
+determining VERB B-O
+viability NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+instead ADV B-O
+viability NOUN B-O
+was AUX B-O
+assessed VERB B-O
+using VERB B-O
+cytosolic ADJ B-O
+mammalian ADJ B-O
+- PUNCT B-O
+specific ADJ B-O
+lactate NOUN B-LF
+dehydrogenase NOUN I-LF
+( PUNCT B-O
+LDH PROPN B-AC
+) PUNCT B-O
+detection NOUN B-O
+in ADP B-O
+supernatants NOUN B-O
+using VERB B-O
+the DET B-O
+CytoTox PROPN B-O
+- PUNCT B-O
+One NUM B-O
+homogeneous ADJ B-O
+membrane NOUN B-O
+integrity NOUN B-O
+assay NOUN B-O
+( PUNCT B-O
+Promega PROPN B-O
+, PUNCT B-O
+Madison PROPN B-O
+, PUNCT B-O
+WI PROPN B-O
+) PUNCT B-O
+as SCONJ B-O
+described VERB B-O
+[ PUNCT B-O
+27 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+on ADP B-O
+sow NOUN B-O
+, PUNCT B-O
+piglet NOUN B-O
+, PUNCT B-O
+weaner NOUN B-O
+and CCONJ B-O
+fattening NOUN B-O
+pig NOUN B-O
+holdings NOUN B-O
+were AUX B-O
+described VERB B-O
+separately ADV B-O
+, PUNCT B-O
+using VERB B-O
+the DET B-O
+semi ADJ B-O
+- ADJ B-O
+annual ADJ B-O
+treatment NOUN B-LF
+frequency NOUN I-LF
+( PUNCT B-O
+TF PROPN B-AC
+) PUNCT B-O
+to PART B-O
+measure VERB B-O
+antibiotic ADJ B-O
+consumption NOUN B-O
+. PUNCT B-O
+
+MHC PROPN B-AC
+, PUNCT B-O
+major ADJ B-LF
+histocompatibility NOUN I-LF
+complex NOUN I-LF
+. PUNCT B-O
+
+Many ADJ B-O
+activation NOUN B-O
+events NOUN B-O
+downstream ADV B-O
+of ADP B-O
+the DET B-O
+T NOUN B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+antigen NOUN I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+TCR PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+up ADV B-O
+- PUNCT B-O
+regulated VERB B-O
+by ADP B-O
+the DET B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+of ADP I-LF
+activated VERB I-LF
+T NOUN I-LF
+cells NOUN I-LF
+( PUNCT B-O
+NFAT PROPN B-AC
+) PUNCT B-O
+transcription NOUN B-O
+factor NOUN B-O
+family NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+copy NOUN B-LF
+number NOUN I-LF
+variation NOUN I-LF
+( PUNCT B-O
+CNV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+well ADV B-O
+- ADJ B-O
+established VERB B-O
+source NOUN B-O
+of ADP B-O
+inter ADJ B-O
+- ADJ B-O
+individual ADJ B-O
+genetic ADJ B-O
+variation NOUN B-O
+[ X B-O
+5 NUM B-O
+, PUNCT B-O
+13 NUM B-O
+, PUNCT B-O
+14 NUM B-O
+] PUNCT B-O
+has AUX B-O
+also ADV B-O
+been AUX B-O
+reported VERB B-O
+to PART B-O
+target VERB B-O
+several ADJ B-O
+FcγR PROPN B-AC
+genes NOUN B-O
+and CCONJ B-O
+can AUX B-O
+alter VERB B-O
+surface NOUN B-O
+FcγR PROPN B-AC
+protein NOUN B-O
+expression NOUN B-O
+and CCONJ B-O
+cellular ADJ B-O
+function NOUN B-O
+[ X B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Humoral ADJ B-O
+allo ADJ B-O
+- PUNCT B-O
+immune ADJ B-O
+responses NOUN B-O
+mediated VERB B-O
+by ADP B-O
+donor NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+antibodies NOUN I-LF
+( PUNCT B-O
+DSA PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+now ADV B-O
+well ADV B-O
+recognized VERB B-O
+as ADP B-O
+a DET B-O
+detrimental ADJ B-O
+determinant NOUN B-O
+of ADP B-O
+graft NOUN B-O
+outcome NOUN B-O
+after ADP B-O
+solid ADJ B-O
+organ NOUN B-O
+transplantation NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+USP6 PROPN B-O
+transgenic VERB B-O
+mice NOUN B-O
+exhibited VERB B-O
+enhanced ADJ B-O
+learning NOUN B-O
+and CCONJ B-O
+memory NOUN B-O
+behavior NOUN B-O
+in ADP B-O
+Morris PROPN B-LF
+water PROPN I-LF
+maze PROPN I-LF
+( PUNCT B-O
+MWM PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+novel ADJ B-LF
+object NOUN I-LF
+recognition NOUN I-LF
+( PUNCT B-O
+NOR PROPN B-AC
+) PUNCT B-O
+tests NOUN B-O
+. PUNCT B-O
+
+Tether NOUN B-O
+proteins NOUN B-O
+attach VERB B-O
+the DET B-O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT B-O
+ER PROPN B-AC
+) PUNCT B-O
+to PART B-O
+other ADJ B-O
+cellular ADJ B-O
+membranes NOUN B-O
+, PUNCT B-O
+thereby ADV B-O
+creating VERB B-O
+contact NOUN B-O
+sites NOUN B-O
+that PRON B-O
+are AUX B-O
+proposed VERB B-O
+to PART B-O
+form VERB B-O
+platforms NOUN B-O
+for ADP B-O
+regulating VERB B-O
+lipid NOUN B-O
+homeostasis NOUN B-O
+and CCONJ B-O
+facilitating VERB B-O
+non ADJ B-O
+- ADJ B-O
+vesicular ADJ B-O
+lipid NOUN B-O
+exchange NOUN B-O
+. PUNCT B-O
+
+Oral ADJ B-LF
+cholera NOUN I-LF
+vaccine NOUN I-LF
+( PUNCT B-O
+OCV PROPN B-AC
+) PUNCT B-O
+plays VERB B-O
+a DET B-O
+key ADJ B-O
+role NOUN B-O
+in ADP B-O
+reducing VERB B-O
+the DET B-O
+near ADJ B-O
+- PUNCT B-O
+term NOUN B-O
+risk NOUN B-O
+of ADP B-O
+cholera NOUN B-O
+, PUNCT B-O
+although SCONJ B-O
+global ADJ B-O
+supplies NOUN B-O
+are AUX B-O
+limited ADJ B-O
+. PUNCT B-O
+
+Emitted VERB B-O
+photons NOUN B-O
+were AUX B-O
+detected VERB B-O
+with ADP B-O
+a DET B-O
+single ADJ B-LF
+- PUNCT I-LF
+photon NOUN I-LF
+avalanche NOUN I-LF
+diode NOUN I-LF
+( PUNCT B-O
+SPAD PROPN B-AC
+) PUNCT B-O
+detector NOUN B-O
+( PUNCT B-O
+SPCM PROPN B-O
+CD3516H PROPN B-O
+; PUNCT B-O
+Excelitas PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+a DET B-O
+time NOUN B-O
+- PUNCT B-O
+correlated VERB B-O
+single ADJ B-O
+- PUNCT B-O
+photon NOUN B-O
+counting VERB B-O
+unit NOUN B-O
+( PUNCT B-O
+HydraHarp PROPN B-O
+400 NUM B-O
+; PUNCT B-O
+PicoQuant PROPN B-O
+) PUNCT B-O
+was AUX B-O
+used VERB B-O
+to PART B-O
+generate VERB B-O
+picosecond NOUN B-O
+histograms NOUN B-O
+( PUNCT B-O
+16 NUM B-O
+ps NOUN B-O
+resolution NOUN B-O
+) PUNCT B-O
+from ADP B-O
+the DET B-O
+photon NOUN B-O
+arrival NOUN B-O
+times NOUN B-O
+. PUNCT B-O
+
+TBB PROPN B-AC
+is AUX B-O
+a DET B-O
+selective ADJ B-O
+, PUNCT B-O
+cell NOUN B-O
+- PUNCT B-O
+permeable ADJ B-O
+, PUNCT B-O
+ATP PROPN B-O
+/ SYM B-O
+GTP NOUN B-O
+- PUNCT B-O
+competitive ADJ B-O
+inhibitor NOUN B-O
+of ADP B-O
+casein NOUN B-LF
+kinase NOUN I-LF
+II NUM I-LF
+( PUNCT B-O
+CKII PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+IC50 NUM B-O
+= SYM B-O
+900 NUM B-O
+nM NOUN B-O
+for ADP B-O
+rat ADJ B-O
+liver NOUN B-O
+) PUNCT B-O
+[ PUNCT B-O
+124 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Berberine PROPN B-LF
+( PUNCT B-O
+BBR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+an DET B-O
+isoquinoline NOUN B-O
+alkaloid NOUN B-O
+isolated VERB B-O
+from ADP B-O
+many ADJ B-O
+medicinal ADJ B-O
+herbs NOUN B-O
+, PUNCT B-O
+is AUX B-O
+one NUM B-O
+of ADP B-O
+the DET B-O
+widely ADV B-O
+used VERB B-O
+traditional ADJ B-O
+Chinese ADJ B-O
+medicines NOUN B-O
+and CCONJ B-O
+has AUX B-O
+been AUX B-O
+used VERB B-O
+to PART B-O
+treat VERB B-O
+various ADJ B-O
+infectious ADJ B-O
+disorders NOUN B-O
+for ADP B-O
+more ADJ B-O
+than ADP B-O
+3,000 NUM B-O
+years NOUN B-O
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Lower ADJ B-LF
+limit NOUN I-LF
+of ADP I-LF
+quantitation NOUN I-LF
+( PUNCT B-O
+LLoQ PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+limit NOUN B-LF
+of ADP I-LF
+detection NOUN I-LF
+( PUNCT B-O
+LoD PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+determined VERB B-O
+by ADP B-O
+measurement NOUN B-O
+precision NOUN B-O
+using VERB B-O
+serial ADJ B-O
+dilutions NOUN B-O
+of ADP B-O
+LAM PROPN B-AC
+extracts NOUN B-O
+obtained VERB B-O
+from ADP B-O
+M. PROPN B-O
+bovis PROPN B-O
+Bacillus PROPN B-O
+Calmette PROPN B-O
+- PUNCT B-O
+Guérin PROPN B-O
+Tokyo PROPN B-O
+( PUNCT B-O
+BCG PROPN B-AC
+) PUNCT B-O
+culture NOUN B-O
+. PUNCT B-O
+
+Before ADP B-O
+dissociation NOUN B-O
+of ADP B-O
+C120 PROPN B-O
+from ADP B-O
+Z775mAG PROPN B-O
+, PUNCT B-O
+the DET B-O
+head NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+head NOUN I-LF
+distance NOUN I-LF
+( PUNCT B-O
+i.e. X B-O
+, PUNCT B-O
+the DET B-O
+distance NOUN B-O
+between ADP B-O
+the DET B-O
+centers NOUN B-O
+of ADP B-O
+mass NOUN B-O
+of ADP B-O
+ZEN-4 NOUN B-O
+motor NOUN B-O
+domains NOUN B-O
+[ X B-O
+DH-H PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+was AUX B-O
+12 NUM B-O
+± SYM B-O
+3 NUM B-O
+nm NOUN B-O
+( PUNCT B-O
+mean ADJ B-O
+± SYM B-O
+SD NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+whereas SCONJ B-O
+, PUNCT B-O
+after ADP B-O
+dissociation NOUN B-O
+, PUNCT B-O
+the DET B-O
+mean ADJ B-O
+DH PROPN B-AC
+increased VERB B-O
+to ADP B-O
+16 NUM B-O
+nm NOUN B-O
+, PUNCT B-O
+with ADP B-O
+a DET B-O
+larger ADJ B-O
+standard ADJ B-O
+deviation NOUN B-O
+of ADP B-O
+6 NUM B-O
+nm NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+6D NUM B-O
+and CCONJ B-O
+6E NUM B-O
+; PUNCT B-O
+for ADP B-O
+additional ADJ B-O
+movies NOUN B-O
+and CCONJ B-O
+head NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+head NOUN I-LF
+distance NOUN I-LF
+measurements NOUN B-O
+, PUNCT B-O
+S11 PROPN B-O
+Movie PROPN B-O
+and CCONJ B-O
+S4A PROPN B-O
+– PUNCT B-O
+S4C PROPN B-O
+Fig PROPN B-O
+, PUNCT B-O
+respectively ADV B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Of ADP B-O
+855,046 NUM B-O
+sequences NOUN B-O
+, PUNCT B-O
+417,953 NUM B-O
+with ADP B-O
+useable ADJ B-O
+reads NOUN B-O
+were AUX B-O
+assignable ADJ B-O
+to ADP B-O
+93 NUM B-O
+operational ADJ B-LF
+taxonomic ADJ I-LF
+units NOUN I-LF
+( PUNCT B-O
+OTUs PROPN B-AC
+) PUNCT B-O
+consisting VERB B-O
+of ADP B-O
+80 NUM B-O
+OTUs PROPN B-AC
+of ADP B-O
+bacteria NOUN B-O
+, PUNCT B-O
+12 NUM B-O
+OTUs PROPN B-AC
+of ADP B-O
+hamster NOUN B-O
+DNA NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+one NUM B-O
+OTU PROPN B-AC
+of ADP B-O
+plant NOUN B-O
+origin NOUN B-O
+. PUNCT B-O
+
+A DET B-O
+1.0 NUM B-O
+m NOUN B-O
+above ADP B-LF
+- PUNCT I-LF
+ground NOUN I-LF
+biomass NOUN I-LF
+( PUNCT B-O
+AGBM PROPN B-AC
+) PUNCT B-O
+sample NOUN B-O
+was AUX B-O
+cut VERB B-O
+from ADP B-O
+the DET B-O
+center NOUN B-O
+row NOUN B-O
+of ADP B-O
+each DET B-O
+plot NOUN B-O
+at ADP B-O
+harvest NOUN B-O
+maturity NOUN B-O
+( PUNCT B-O
+grain NOUN B-O
+moisture NOUN B-O
+concentration NOUN B-O
+≤ PUNCT B-O
+160 NUM B-O
+g NOUN B-O
+kg-1 NUM B-O
+) PUNCT B-O
+in ADP B-O
+all DET B-O
+testing NOUN B-O
+environments NOUN B-O
+. PUNCT B-O
+
+Cathepsin PROPN B-LF
+D PROPN I-LF
+( PUNCT B-O
+CD PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+lysosomal ADJ B-O
+protease NOUN B-O
+previously ADV B-O
+demonstrated VERB B-O
+to PART B-O
+cleave VERB B-O
+α PUNCT B-O
+- NOUN B-O
+syn NOUN B-O
+and CCONJ B-O
+decrease VERB B-O
+its PRON B-O
+toxicity NOUN B-O
+in ADP B-O
+cell NOUN B-O
+lines NOUN B-O
+[ PUNCT B-O
+18 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This PRON B-O
+is AUX B-O
+promising ADJ B-O
+especially ADV B-O
+concerning VERB B-O
+cardiomyocyte NOUN B-O
+damage NOUN B-O
+following VERB B-O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+( PUNCT B-O
+MI PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+heart NOUN B-O
+failure NOUN B-O
+in ADP B-O
+CVD PROPN B-AC
+patients NOUN B-O
+. PUNCT B-O
+
+Liver PROPN B-O
+disease NOUN B-O
+severity NOUN B-O
+was AUX B-O
+assessed VERB B-O
+using VERB B-O
+the DET B-O
+Child PROPN B-LF
+Pugh PROPN I-LF
+Score PROPN I-LF
+( PUNCT B-O
+CPS PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Model PROPN B-LF
+for ADP I-LF
+End PROPN I-LF
+- PUNCT I-LF
+stage NOUN I-LF
+Liver PROPN I-LF
+Disease PROPN I-LF
+( PUNCT B-O
+MELD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+medical ADJ B-O
+comorbidities NOUN B-O
+were AUX B-O
+assessed VERB B-O
+using VERB B-O
+the DET B-O
+Charlson PROPN B-LF
+Comorbidity PROPN I-LF
+Index PROPN I-LF
+( PUNCT B-O
+CCI PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+11 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+An DET B-O
+analysis NOUN B-O
+of ADP B-O
+microtubule NOUN B-LF
+associated VERB I-LF
+protein NOUN I-LF
+2 NUM I-LF
+( PUNCT B-O
+MAP2)- PROPN B-AC
+and CCONJ B-O
+Nissl PROPN B-O
+- ADJ B-O
+stained VERB B-O
+Ngl3−/− PROPN B-O
+slices NOUN B-O
+revealed VERB B-O
+that SCONJ B-O
+the DET B-O
+gross ADJ B-O
+morphology NOUN B-O
+of ADP B-O
+the DET B-O
+Ngl3−/−(Hyb PROPN B-O
+) PUNCT B-O
+brain NOUN B-O
+was AUX B-O
+largely ADV B-O
+normal ADJ B-O
+, PUNCT B-O
+except SCONJ B-O
+for ADP B-O
+an DET B-O
+apparent ADJ B-O
+decrease NOUN B-O
+in ADP B-O
+the DET B-O
+size NOUN B-O
+of ADP B-O
+the DET B-O
+thalamus NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1F NUM B-O
+and CCONJ B-O
+1 NUM B-O
+G NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Levels NOUN B-O
+of ADP B-O
+NGL-3 PROPN B-AC
+relatives NOUN B-O
+( PUNCT B-O
+NGL-1 PROPN B-O
+and CCONJ B-O
+NGL-2 PROPN B-O
+) PUNCT B-O
+were AUX B-O
+normal ADJ B-O
+in ADP B-O
+the DET B-O
+Ngl3−/−(Hyb PROPN B-O
+) PUNCT B-O
+brains NOUN B-O
+( PUNCT B-O
+3 NUM B-O
+and CCONJ B-O
+10 NUM B-O
+weeks NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+although SCONJ B-O
+levels NOUN B-O
+of ADP B-O
+PTPδ PROPN B-AC
+, PUNCT B-O
+a DET B-O
+trans ADJ B-O
+- ADJ B-O
+synaptic ADJ B-O
+partner NOUN B-O
+of ADP B-O
+NGL-3 PROPN B-AC
+, PUNCT B-O
+were AUX B-O
+reduced VERB B-O
+( PUNCT B-O
+S2 PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+IFOF PROPN B-AC
+, PUNCT B-O
+inferior ADJ B-LF
+fronto ADJ I-LF
+- PUNCT I-LF
+occipital ADJ I-LF
+fascicle NOUN I-LF
+; PUNCT B-O
+ILF PROPN B-AC
+, PUNCT B-O
+inferior ADJ B-LF
+longitudinal ADJ I-LF
+fascicle NOUN I-LF
+; PUNCT B-O
+ILFlat PROPN B-AC
+, PUNCT B-O
+inferior ADJ B-LF
+longitudinal ADJ I-LF
+fascicle NOUN I-LF
+lateral ADJ B-O
+; PUNCT B-O
+ILFmed PROPN B-AC
+, PUNCT B-O
+inferior ADJ B-LF
+longitudinal ADJ I-LF
+fascicle NOUN I-LF
+medial ADJ B-O
+; PUNCT B-O
+MdLF PROPN B-AC
+, PUNCT B-O
+middle ADJ B-LF
+longitudinal ADJ I-LF
+fascicle NOUN I-LF
+; PUNCT B-O
+PRIME PROPN B-O
+- PUNCT B-O
+DE PROPN B-O
+, PUNCT B-O
+Primate PROPN B-O
+Data PROPN B-O
+Exchange PROPN B-O
+. PUNCT B-O
+
+Recent ADJ B-O
+work NOUN B-O
+suggests VERB B-O
+that SCONJ B-O
+a DET B-O
+T NOUN B-O
+cell NOUN B-O
+- PUNCT B-O
+based VERB B-O
+assay NOUN B-O
+for ADP B-O
+interferon NOUN B-O
+gamma NOUN B-O
+, PUNCT B-O
+the DET B-O
+enzyme NOUN B-LF
+- PUNCT I-LF
+linked VERB I-LF
+immunosorbent ADJ I-LF
+spot NOUN I-LF
+test NOUN I-LF
+( PUNCT B-O
+ELISPOT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+has VERB B-O
+promise NOUN B-O
+in ADP B-O
+the DET B-O
+diagnosis NOUN B-O
+of ADP B-O
+Mycobacterium PROPN B-O
+tuberculosis NOUN B-LF
+infection NOUN B-O
+after ADP B-O
+exposure NOUN B-O
+to ADP B-O
+a DET B-O
+known VERB B-O
+tuberculosis NOUN B-LF
+( PUNCT B-O
+TB PROPN B-AC
+) PUNCT B-O
+patient NOUN B-O
+[ X B-O
+1–3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+NB PROPN B-O
+: PUNCT B-O
+GLIA PROPN B-AC
+: PUNCT B-O
+Guideline PROPN B-LF
+Implementability PROPN I-LF
+Appraisal PROPN I-LF
+, PUNCT B-O
+SD PROPN B-O
+: PUNCT B-O
+standard ADJ B-O
+deviation NOUN B-O
+, PUNCT B-O
+% NOUN B-O
+age NOUN B-O
+score NOUN B-O
+: PUNCT B-O
+percentage NOUN B-O
+score NOUN B-O
+EF PROPN B-O
+– PUNCT B-O
+Ejection PROPN B-O
+Fraction PROPN B-O
+, PUNCT B-O
+EDV PROPN B-O
+– PUNCT B-O
+End PROPN B-O
+diastolic ADJ B-O
+volume NOUN B-O
+index NOUN B-O
+, PUNCT B-O
+ESVI PROPN B-O
+– PUNCT B-O
+End PROPN B-O
+systolic ADJ B-O
+volume NOUN B-O
+index NOUN B-O
+, PUNCT B-O
+LV PROPN B-AC
+– PUNCT B-O
+left ADJ B-LF
+ventricle NOUN I-LF
+, PUNCT B-O
+RV NOUN B-O
+– PUNCT B-O
+right ADJ B-O
+ventricle NOUN B-O
+, PUNCT B-O
+SVI NOUN B-O
+– PUNCT B-O
+stroke NOUN B-O
+volume NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+surface NOUN B-O
+- PUNCT B-O
+exposed VERB B-O
+P2 NOUN B-O
+subdomain NOUN B-O
+( PUNCT B-O
+residues NOUN B-O
+279–405 NUM B-O
+) PUNCT B-O
+[ X B-O
+17 X B-O
+] PUNCT B-O
+interacts VERB B-O
+with ADP B-O
+histoblood NOUN B-LF
+group NOUN I-LF
+antigens NOUN I-LF
+( PUNCT B-O
+HBGAs PROPN B-AC
+) PUNCT B-O
+expressed VERB B-O
+on ADP B-O
+gut ADJ B-O
+epithelial ADJ B-O
+cells NOUN B-O
+, PUNCT B-O
+facilitating VERB B-O
+virus NOUN B-O
+binding NOUN B-O
+and CCONJ B-O
+entry NOUN B-O
+resulting VERB B-O
+in ADP B-O
+infection NOUN B-O
+[ X B-O
+18 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Within ADP B-O
+the DET B-O
+ALs PROPN B-AC
+, PUNCT B-O
+the DET B-O
+olfactory ADJ B-O
+information NOUN B-O
+is AUX B-O
+processed VERB B-O
+by ADP B-O
+a DET B-O
+complex ADJ B-O
+network NOUN B-O
+of ADP B-O
+neurons NOUN B-O
+, PUNCT B-O
+including VERB B-O
+OSNs PROPN B-AC
+, PUNCT B-O
+local ADJ B-LF
+interneurons NOUN I-LF
+( PUNCT B-O
+LNs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+projection NOUN B-LF
+neurons NOUN I-LF
+( PUNCT B-O
+PNs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+centrifugal ADJ B-LF
+neurons NOUN I-LF
+( PUNCT B-O
+CNs PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Genetic ADJ B-O
+- PUNCT B-O
+variation NOUN B-O
+studies NOUN B-O
+have AUX B-O
+primarily ADV B-O
+been AUX B-O
+focused VERB B-O
+on ADP B-O
+tumor NOUN B-O
+somatic ADJ B-O
+mutations NOUN B-O
+or CCONJ B-O
+on ADP B-O
+germline ADJ B-O
+single ADJ B-LF
+- PUNCT I-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT B-O
+SNPs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+AID PROPN B-AC
+, PUNCT B-O
+auxin NOUN B-LF
+- PUNCT I-LF
+inducible ADJ I-LF
+degron NOUN I-LF
+; PUNCT B-O
+CENP PROPN B-AC
+, PUNCT B-O
+centromere NOUN B-LF
+protein NOUN I-LF
+A NOUN I-LF
+; PUNCT B-O
+-AFL PROPN B-AC
+, PUNCT B-O
+full ADJ B-LF
+- PUNCT I-LF
+length NOUN I-LF
+; PUNCT B-O
+IF PROPN B-AC
+, PUNCT B-O
+immunofluorescence NOUN B-LF
+; PUNCT B-O
+RNAi PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT B-O
+WT PROPN B-O
+, PUNCT B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+order NOUN B-O
+to PART B-O
+delineate VERB B-O
+the DET B-O
+complex ADJ B-O
+relationship NOUN B-O
+among ADP B-O
+chain NOUN B-O
+connectivity NOUN B-O
+, PUNCT B-O
+protein NOUN B-O
+folding NOUN B-O
+, PUNCT B-O
+coupled VERB B-O
+networks NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+catalysis NOUN B-O
+by ADP B-O
+DHFR PROPN B-AC
+, PUNCT B-O
+we PRON B-O
+have AUX B-O
+carried VERB B-O
+out ADP B-O
+a DET B-O
+systematic ADJ B-O
+network NOUN B-O
+analysis NOUN B-O
+and CCONJ B-O
+molecular ADJ B-LF
+dynamics NOUN I-LF
+( PUNCT B-O
+MD PROPN B-AC
+) PUNCT B-O
+simulations NOUN B-O
+of ADP B-O
+the DET B-O
+native ADJ B-O
+( PUNCT B-O
+closed ADJ B-O
+state NOUN B-O
+) PUNCT B-O
+DHFR PROPN B-AC
+and CCONJ B-O
+19 NUM B-O
+of ADP B-O
+its PRON B-O
+circularly ADV B-O
+permuted ADJ B-O
+variants NOUN B-O
+. PUNCT B-O
+
+Cervical ADJ B-O
+cancer NOUN B-O
+is AUX B-O
+mainly ADV B-O
+caused VERB B-O
+by ADP B-O
+sexually ADV B-O
+transmitted VERB B-O
+Human PROPN B-LF
+Papilloma PROPN I-LF
+Virus PROPN I-LF
+( PUNCT B-O
+HPV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+the DET B-O
+most ADV B-O
+common ADJ B-O
+viral ADJ B-O
+infection NOUN B-O
+of ADP B-O
+the DET B-O
+female ADJ B-O
+reproductive ADJ B-O
+tract NOUN B-O
+. PUNCT B-O
+
+Combining VERB B-O
+sensitivity NOUN B-O
+and CCONJ B-O
+specificity NOUN B-O
+, PUNCT B-O
+we PRON B-O
+calculated VERB B-O
+likelihood NOUN B-LF
+ratios NOUN I-LF
+( PUNCT B-O
+LR PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+different ADJ B-O
+cut VERB B-O
+- PUNCT B-O
+off ADP B-O
+points NOUN B-O
+. PUNCT B-O
+
+MDA PROPN B-AC
+levels NOUN B-O
+in ADP B-O
+cell NOUN B-O
+lysates NOUN B-O
+were AUX B-O
+determined VERB B-O
+by ADP B-O
+high ADJ B-LF
+- PUNCT I-LF
+performance NOUN I-LF
+liquid NOUN I-LF
+chromatography NOUN I-LF
+( PUNCT B-O
+HPLC PROPN B-AC
+) PUNCT B-O
+as SCONJ B-O
+shown VERB B-O
+previously ADV B-O
+[ X B-O
+31 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+At ADP B-O
+the DET B-O
+end NOUN B-O
+of ADP B-O
+the DET B-O
+study NOUN B-O
+, PUNCT B-O
+CO NOUN B-O
+concentration NOUN B-O
+in ADP B-O
+the DET B-O
+exhaled VERB B-O
+gas NOUN B-O
+of ADP B-O
+each DET B-O
+participant NOUN B-O
+was AUX B-O
+measured VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+indoor ADJ B-O
+air NOUN B-O
+pollutants NOUN B-O
+( PUNCT B-O
+i.e. X B-O
+, PUNCT B-O
+SO2 NOUN B-O
+, PUNCT B-O
+CO NOUN B-O
+, PUNCT B-O
+CO2 NOUN B-O
+, PUNCT B-O
+NO2 NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+particulate NOUN B-LF
+matter NOUN I-LF
+with ADP I-LF
+an DET I-LF
+aerodynamic ADJ I-LF
+diameter NOUN I-LF
+of ADP I-LF
+10 NUM I-LF
+µm NOUN I-LF
+or CCONJ I-LF
+less ADJ I-LF
+[ PUNCT B-O
+PM10 PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+were AUX B-O
+measured VERB B-O
+for ADP B-O
+one NUM B-O
+- PUNCT B-O
+third NOUN B-O
+of ADP B-O
+the DET B-O
+participants NOUN B-O
+' PART B-O
+homes NOUN B-O
+, PUNCT B-O
+which PRON B-O
+were AUX B-O
+randomly ADV B-O
+selected VERB B-O
+through ADP B-O
+a DET B-O
+systematic ADJ B-O
+random ADJ B-O
+process NOUN B-O
+as SCONJ B-O
+previously ADV B-O
+described VERB B-O
+for ADP B-O
+the DET B-O
+baseline NOUN B-O
+survey NOUN B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+we PRON B-O
+used VERB B-O
+RNA NOUN B-LF
+interference NOUN I-LF
+( PUNCT B-O
+RNAi PROPN B-AC
+) PUNCT B-O
+to PART B-O
+systematically ADV B-O
+investigate VERB B-O
+the DET B-O
+roles NOUN B-O
+of ADP B-O
+Acps PROPN B-AC
+in ADP B-O
+inducing VERB B-O
+changes NOUN B-O
+in ADP B-O
+egg NOUN B-O
+laying NOUN B-O
+, PUNCT B-O
+fertility NOUN B-O
+, PUNCT B-O
+receptivity NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+sperm NOUN B-O
+storage NOUN B-O
+. PUNCT B-O
+
+Over ADP B-O
+recent ADJ B-O
+years NOUN B-O
+, PUNCT B-O
+the DET B-O
+use NOUN B-O
+of ADP B-O
+novel ADJ B-O
+agents NOUN B-O
+( PUNCT B-O
+immunomodulatory ADJ B-O
+drugs NOUN B-O
+[ X B-O
+lenalidomide NOUN B-O
+, PUNCT B-O
+thalidomide NOUN B-O
+and CCONJ B-O
+pomalidomide NOUN B-O
+] PUNCT B-O
+and CCONJ B-O
+the DET B-O
+proteasome NOUN B-O
+inhibitor NOUN B-O
+[ X B-O
+bortezomib NOUN B-O
+] PUNCT B-O
+) PUNCT B-O
+and CCONJ B-O
+autologous ADJ B-LF
+stem NOUN I-LF
+cell NOUN I-LF
+transplant NOUN I-LF
+( PUNCT B-O
+ASCT PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+patients NOUN B-O
+eligible ADJ B-O
+for ADP B-O
+transplant NOUN B-O
+has AUX B-O
+improved VERB B-O
+the DET B-O
+outcomes NOUN B-O
+of ADP B-O
+patients NOUN B-O
+with ADP B-O
+MM PROPN B-AC
+around ADP B-O
+the DET B-O
+world NOUN B-O
+[ X B-O
+2–6 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Apnea NOUN B-LF
+- NOUN I-LF
+Hypopnea NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+AHI PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+oxygen NOUN B-LF
+de NOUN I-LF
+- NOUN I-LF
+saturation NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+ODI PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+also ADV B-O
+independent ADJ B-O
+factors NOUN B-O
+of ADP B-O
+DNA NOUN B-O
+methylation NOUN B-O
+levels NOUN B-O
+of ADP B-O
+the DET B-O
+TLR2 NOUN B-O
+promoter NOUN B-O
+region NOUN B-O
+, PUNCT B-O
+TLR6 NOUN B-O
+gene NOUN B-O
+body NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+protein NOUN B-O
+expressions NOUN B-O
+of ADP B-O
+TLR6 NOUN B-O
+( PUNCT B-O
+S4 PROPN B-O
+and CCONJ B-O
+S5 PROPN B-O
+Tables NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Subgroup NOUN B-O
+comparisons NOUN B-O
+of ADP B-O
+the DET B-O
+weighted VERB B-O
+mean ADJ B-O
+difference NOUN B-O
+of ADP B-O
+diastolic ADJ B-O
+blood NOUN B-O
+pressure NOUN B-O
+between ADP B-O
+South PROPN B-LF
+Asians PROPN I-LF
+( PUNCT B-O
+SA PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+European ADJ B-O
+participants NOUN B-O
+( PUNCT B-O
+EU PROPN B-AC
+) PUNCT B-O
+by ADP B-O
+country NOUN B-O
+of ADP B-O
+origin NOUN B-O
+. PUNCT B-O
+
+Quantitative ADJ B-O
+measurement NOUN B-O
+of ADP B-O
+lipid NOUN B-O
+peroxidation NOUN B-O
+was AUX B-O
+performed VERB B-O
+in ADP B-O
+cell NOUN B-O
+homogenates NOUN B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+methods NOUN B-O
+of ADP B-O
+Tappel PROPN B-O
+and CCONJ B-O
+Zalkin PROPN B-O
+, PUNCT B-O
+1959 NUM B-O
+[ PUNCT B-O
+33 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+based VERB B-O
+on ADP B-O
+the DET B-O
+formation NOUN B-O
+of ADP B-O
+thiobarbituric NOUN B-LF
+acid NOUN I-LF
+reactive ADJ I-LF
+substances NOUN I-LF
+( PUNCT B-O
+TBARS PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+expressed VERB B-O
+as ADP B-O
+the DET B-O
+extent NOUN B-O
+of ADP B-O
+malondialdehyde NOUN B-LF
+( PUNCT B-O
+MDA PROPN B-AC
+) PUNCT B-O
+production NOUN B-O
+. PUNCT B-O
+
+All DET B-O
+villages NOUN B-O
+were AUX B-O
+Primary PROPN B-LF
+Health PROPN I-LF
+Care PROPN I-LF
+Programme PROPN I-LF
+( PUNCT B-O
+PHC PROPN B-AC
+) PUNCT B-O
+villages NOUN B-O
+and CCONJ B-O
+had AUX B-O
+a DET B-O
+male ADJ B-O
+village NOUN B-LF
+health NOUN I-LF
+worker NOUN I-LF
+( PUNCT B-O
+VHW PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+a DET B-O
+traditional ADJ B-LF
+birth NOUN I-LF
+attendant NOUN I-LF
+( PUNCT B-O
+TBA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+both PRON B-O
+of ADP B-O
+whom PRON B-O
+had AUX B-O
+completed VERB B-O
+a DET B-O
+4 NUM B-O
+- PUNCT B-O
+week NOUN B-O
+Gambian ADJ B-O
+Ministry PROPN B-O
+of ADP B-O
+Health PROPN B-O
+( PUNCT B-O
+MoH PROPN B-O
+) PUNCT B-O
+training NOUN B-O
+programme NOUN B-O
+. PUNCT B-O
+
+E10.5 PROPN B-AC
+, PUNCT B-O
+embryonic ADJ B-LF
+day NOUN I-LF
+10.5 NUM I-LF
+; PUNCT B-O
+E11.5 PROPN B-AC
+, PUNCT B-O
+embryonic ADJ B-LF
+day NOUN I-LF
+11.5 NUM I-LF
+; PUNCT B-O
+EP PROPN B-O
+, PUNCT B-O
+embryo NOUN B-O
+proper ADJ B-O
+; PUNCT B-O
+HM PROPN B-O
+Ripk1D325A PROPN B-O
+/ SYM B-O
+D325A NOUN B-O
+homozygotes NOUN B-O
+; PUNCT B-O
+NF PROPN B-AC
+, PUNCT B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+- PUNCT I-LF
+kappa NOUN I-LF
+B NOUN I-LF
+; PUNCT B-O
+-κBWT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+; PUNCT B-O
+YS NOUN B-O
+, PUNCT B-O
+yolk NOUN B-O
+sac NOUN B-O
+. PUNCT B-O
+
+These DET B-O
+PRRs PROPN B-AC
+include VERB B-O
+Toll NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptors NOUN I-LF
+( PUNCT B-O
+TLRs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+receptor NOUN B-LF
+for ADP I-LF
+advanced ADJ I-LF
+glycation NOUN I-LF
+end NOUN I-LF
+products NOUN I-LF
+( PUNCT B-O
+RAGE PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+scavenger NOUN B-O
+receptors NOUN B-O
+[ PUNCT B-O
+59–61 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+B. PROPN B-O
+malayi NOUN B-O
+microfilaria NOUN B-O
+worms NOUN B-O
+were AUX B-O
+purchased VERB B-O
+from ADP B-O
+TRS PROPN B-O
+Labs PROPN B-O
+( PUNCT B-O
+Athens PROPN B-O
+, PUNCT B-O
+GA PROPN B-O
+, PUNCT B-O
+United PROPN B-O
+States PROPN B-O
+) PUNCT B-O
+for ADP B-O
+preparation NOUN B-O
+of ADP B-O
+DNA NOUN B-O
+. PUNCT B-O
+
+Because SCONJ B-O
+of ADP B-O
+the DET B-O
+difficulties NOUN B-O
+in ADP B-O
+obtaining VERB B-O
+purified ADJ B-O
+Wolbachia PROPN B-O
+DNA NOUN B-O
+from ADP B-O
+the DET B-O
+B. PROPN B-O
+malayi NOUN B-O
+host NOUN B-O
+, PUNCT B-O
+bacterial ADJ B-LF
+artificial ADJ I-LF
+chromosome NOUN I-LF
+( PUNCT B-O
+BAC PROPN B-AC
+) PUNCT B-O
+libraries NOUN B-O
+were AUX B-O
+created VERB B-O
+[ PUNCT B-O
+114 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+treatment NOUN B-O
+regimen NOUN B-O
+developed VERB B-O
+from ADP B-O
+this DET B-O
+dose NOUN B-O
+- ADJ B-O
+finding VERB B-O
+study NOUN B-O
+has AUX B-O
+now ADV B-O
+been AUX B-O
+carried VERB B-O
+forward ADV B-O
+into ADP B-O
+the DET B-O
+DIABIL-2 PROPN B-O
+clinical ADJ B-O
+trial NOUN B-O
+to PART B-O
+assess VERB B-O
+the DET B-O
+efficacy NOUN B-O
+and CCONJ B-O
+safety NOUN B-O
+of ADP B-O
+ultra ADJ B-O
+- ADJ B-O
+low ADJ B-O
+doses NOUN B-O
+of ADP B-O
+recombinant ADJ B-LF
+human ADJ I-LF
+IL-2 NOUN I-LF
+( PUNCT B-O
+rhIL-2 PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+children NOUN B-O
+and CCONJ B-O
+adults NOUN B-O
+with ADP B-O
+T1D PROPN B-AC
+[ PUNCT B-O
+37 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+516 NUM B-O
+conceptus NOUN B-O
+cells NOUN B-O
+consist VERB B-O
+of ADP B-O
+cells NOUN B-O
+of ADP B-O
+EPI PROPN B-AC
+, PUNCT B-O
+primitive ADJ B-LF
+endoderm NOUN I-LF
+( PUNCT B-O
+PE PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+TE PROPN B-AC
+lineages NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+animals NOUN B-O
+, PUNCT B-O
+mutation NOUN B-O
+or CCONJ B-O
+RNA NOUN B-LF
+interference NOUN I-LF
+( PUNCT B-O
+RNAi PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+individual ADJ B-O
+Wnt PROPN B-O
+genes NOUN B-O
+did AUX B-O
+not PART B-O
+reduce VERB B-O
+the DET B-O
+normal ADJ B-O
+frequency NOUN B-O
+of ADP B-O
+vulval ADJ B-O
+fates NOUN B-O
+( PUNCT B-O
+Table PROPN B-O
+2 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Beyond ADP B-O
+JIA PROPN B-AC
+, PUNCT B-O
+our PRON B-O
+approach NOUN B-O
+may AUX B-O
+be AUX B-O
+a DET B-O
+transferrable ADJ B-O
+template NOUN B-O
+for ADP B-O
+application NOUN B-O
+in ADP B-O
+rheumatoid ADJ B-LF
+arthritis NOUN I-LF
+( PUNCT B-O
+RA PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+spondyloarthropathies NOUN B-O
+( PUNCT B-O
+SpAs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Error NOUN B-O
+bars NOUN B-O
+indicated VERB B-O
+SEM PROPN B-O
+. PUNCT B-O
+
+AAV PROPN B-AC
+, PUNCT B-O
+adeno NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+virus NOUN I-LF
+; PUNCT B-O
+ANOVA PROPN B-AC
+, PUNCT B-O
+Analysis PROPN B-LF
+of ADP I-LF
+Variance NOUN I-LF
+; PUNCT B-O
+DHPG PROPN B-AC
+, PUNCT B-O
+( PUNCT B-O
+S)-3,5 NOUN B-O
+- PUNCT B-O
+Dihydroxyphenylglycine NOUN B-O
+; PUNCT B-O
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+GlyR PROPN B-AC
+, PUNCT B-O
+glycine NOUN B-LF
+receptor NOUN I-LF
+; PUNCT B-O
+IPSC PROPN B-AC
+, PUNCT B-O
+inhibitory ADJ B-LF
+postsynaptic ADJ I-LF
+current NOUN I-LF
+; PUNCT B-O
+mIPSC PROPN B-AC
+, PUNCT B-O
+miniature ADJ B-LF
+IPSC NOUN I-LF
+IPSC PROPN B-AC
+; PUNCT B-O
+NC PROPN B-AC
+, PUNCT B-O
+negative ADJ B-LF
+control NOUN I-LF
+shRNA NOUN I-LF
+shRNA PROPN B-AC
+; PUNCT B-O
+RPM PROPN B-AC
+, PUNCT B-O
+rounds NOUN B-LF
+per ADP I-LF
+minute NOUN I-LF
+; PUNCT B-O
+shRNA PROPN B-AC
+, PUNCT B-O
+short ADJ B-LF
+hairpin NOUN I-LF
+RNA NOUN I-LF
+. PUNCT B-O
+
+The DET B-O
+WHO PROPN B-O
+group NOUN B-O
+wanted VERB B-O
+to ADP B-O
+know VERB B-O
+how SCONJ B-O
+these DET B-O
+treatments NOUN B-O
+affected VERB B-O
+the DET B-O
+virus NOUN B-O
+outside ADP B-O
+the DET B-O
+body NOUN B-O
+( PUNCT B-O
+“ PUNCT B-O
+in ADP B-O
+vitro X B-O
+” PUNCT B-O
+) PUNCT B-O
+and CCONJ B-O
+whether SCONJ B-O
+it PRON B-O
+helped VERB B-O
+the DET B-O
+condition NOUN B-O
+of ADP B-O
+patients NOUN B-O
+and CCONJ B-O
+reduced VERB B-O
+the DET B-O
+death NOUN B-O
+rate NOUN B-O
+, PUNCT B-O
+particularly ADV B-O
+in ADP B-O
+those DET B-O
+patients NOUN B-O
+who PRON B-O
+developed VERB B-O
+the DET B-O
+dangerous ADJ B-O
+complication NOUN B-O
+called VERB B-O
+acute ADJ B-LF
+respiratory ADJ I-LF
+distress NOUN I-LF
+syndrome NOUN I-LF
+( PUNCT B-O
+ARDS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+is AUX B-O
+a DET B-O
+systematic ADJ B-O
+review NOUN B-O
+conducted VERB B-O
+in ADP B-O
+response NOUN B-O
+to ADP B-O
+the DET B-O
+WHO PROPN B-O
+request NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+Hippo PROPN B-O
+signaling NOUN B-O
+pathway NOUN B-O
+, PUNCT B-O
+( PUNCT B-O
+B X B-O
+) PUNCT B-O
+Focal ADJ B-O
+adhesion NOUN B-O
+and CCONJ B-O
+( PUNCT B-O
+C X B-O
+) PUNCT B-O
+Cell NOUN B-LF
+adhesion NOUN I-LF
+molecules NOUN I-LF
+( PUNCT B-O
+CAMs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Fluorescence NOUN B-LF
+recovery NOUN I-LF
+after ADP I-LF
+photobleaching NOUN I-LF
+( PUNCT B-O
+FRAP PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+performed VERB B-O
+to PART B-O
+compare VERB B-O
+the DET B-O
+mobility NOUN B-O
+and CCONJ B-O
+dynamics NOUN B-O
+of ADP B-O
+the DET B-O
+mutant ADJ B-O
+variants NOUN B-O
+with ADP B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+myotilin NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+5A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+myotilin NOUN B-O
+showed VERB B-O
+rapid ADJ B-O
+dynamics NOUN B-O
+with ADP B-O
+80 NUM B-O
+% NOUN B-O
+fluorescence NOUN B-O
+recovery NOUN B-O
+after ADP B-O
+300 NUM B-O
+s NOUN B-O
+( PUNCT B-O
+median ADJ B-O
+half ADJ B-O
+- PUNCT B-O
+time NOUN B-O
+t1/2 NUM B-O
+of ADP B-O
+72.4 NUM B-O
+s NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Fig NOUN B-O
+5B NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+in ADP B-O
+excellent ADJ B-O
+agreement NOUN B-O
+with ADP B-O
+previously ADV B-O
+published VERB B-O
+reports NOUN B-O
+[ PUNCT B-O
+50,51 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+ability NOUN B-O
+of ADP B-O
+α PUNCT B-LF
+- PUNCT I-LF
+methyl NOUN I-LF
+- PUNCT I-LF
+p NOUN I-LF
+- PUNCT I-LF
+tyrosine NOUN I-LF
+( PUNCT B-O
+αMT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+potent ADJ B-O
+irreversible ADJ B-O
+inhibitor NOUN B-O
+of ADP B-O
+TH PROPN B-AC
+[ PUNCT B-O
+29,45,46 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+to PART B-O
+impede VERB B-O
+production NOUN B-O
+of ADP B-O
+brain NOUN B-O
+DA PROPN B-AC
+suggests VERB B-O
+a DET B-O
+simple ADJ B-O
+, PUNCT B-O
+but CCONJ B-O
+straightforward ADJ B-O
+, PUNCT B-O
+strategy NOUN B-O
+for ADP B-O
+producing VERB B-O
+an DET B-O
+acute ADJ B-O
+PD PROPN B-AC
+mouse NOUN B-O
+model NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+this DET B-O
+context NOUN B-O
+, PUNCT B-O
+adult NOUN B-O
+bone NOUN B-O
+marrow NOUN B-O
+derived VERB B-O
+mesenchymal ADJ B-LF
+stem NOUN I-LF
+cells NOUN I-LF
+( PUNCT B-O
+BM-MSCs PROPN B-AC
+) PUNCT B-O
+represent VERB B-O
+the DET B-O
+most ADV B-O
+studied ADJ B-O
+cell NOUN B-O
+type NOUN B-O
+for ADP B-O
+cardiac ADJ B-O
+repair NOUN B-O
+due ADP B-O
+to ADP B-O
+their PRON B-O
+unique ADJ B-O
+features NOUN B-O
+including VERB B-O
+the DET B-O
+ease NOUN B-O
+in ADP B-O
+their PRON B-O
+isolation NOUN B-O
+/ SYM B-O
+expansion NOUN B-O
+, PUNCT B-O
+their PRON B-O
+paracrine NOUN B-O
+activity NOUN B-O
+to ADP B-O
+induce VERB B-O
+neovascularization ADJ B-O
+post ADJ B-O
+ischemic ADJ B-O
+injury NOUN B-O
+and CCONJ B-O
+most ADV B-O
+importantly ADV B-O
+due ADP B-O
+to ADP B-O
+their PRON B-O
+immunomodulatory ADJ B-O
+properties NOUN B-O
+[ X B-O
+1–5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Arrow NOUN B-O
+indicates VERB B-O
+BRCA2 PROPN B-O
+deficiency NOUN B-O
+threshold NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+C X B-O
+) PUNCT B-O
+Number NOUN B-O
+of ADP B-O
+silent ADJ B-O
+or CCONJ B-O
+non ADJ B-O
+- PUNCT B-O
+silent ADJ B-O
+mutations NOUN B-O
+, PUNCT B-O
+mutation NOUN B-O
+signatures NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+BRCA PROPN B-O
+deficiency NOUN B-O
+in ADP B-O
+TCGA PROPN B-AC
+TNBCs PROPN B-AC
+. PUNCT B-O
+
+BRCA-D PROPN B-AC
+, PUNCT B-O
+BRCA PROPN B-LF
+- PUNCT I-LF
+deficient ADJ I-LF
+; PUNCT B-O
+BRCA PROPN B-AC
+, PUNCT B-O
+BRCA PROPN B-LF
+- PUNCT I-LF
+normal ADJ I-LF
+; PUNCT B-O
+CNV PROPN B-O
+, PUNCT B-O
+copy NOUN B-O
+number NOUN B-O
+variation NOUN B-O
+; PUNCT B-O
+MMR PROPN B-O
+, PUNCT B-O
+mismatch NOUN B-O
+repair NOUN B-O
+; PUNCT B-O
+Mut PROPN B-O
+, PUNCT B-O
+mutation NOUN B-O
+; PUNCT B-O
+SNV PROPN B-O
+, PUNCT B-O
+single ADJ B-O
+nucleotide NOUN B-O
+variant NOUN B-O
+; PUNCT B-O
+-NTCGA PROPN B-AC
+, PUNCT B-O
+The PRON B-LF
+Cancer PROPN I-LF
+Genome PROPN I-LF
+Atlas PROPN I-LF
+; PUNCT B-O
+TNBC PROPN B-AC
+, PUNCT B-O
+triple ADV B-LF
+negative ADJ I-LF
+breast NOUN I-LF
+cancer NOUN I-LF
+; PUNCT B-O
+WT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT B-O
+
+The DET B-O
+Circumplex PROPN B-LF
+of ADP I-LF
+Interpersonal PROPN I-LF
+Problems PROPN I-LF
+( PUNCT B-O
+CIP PROPN B-AC
+) PUNCT B-O
+[ X B-O
+64 X B-O
+] X B-O
+was AUX B-O
+used VERB B-O
+to PART B-O
+assess VERB B-O
+interpersonal ADJ B-O
+personal ADJ B-O
+problems NOUN B-O
+. PUNCT B-O
+
+Data NOUN B-O
+can AUX B-O
+be AUX B-O
+made VERB B-O
+available ADJ B-O
+by ADP B-O
+the DET B-O
+Health PROPN B-LF
+Informatics PROPN I-LF
+Centre PROPN I-LF
+, PUNCT B-O
+University PROPN B-O
+of ADP B-O
+Dundee PROPN B-O
+( PUNCT B-O
+contact VERB B-O
+via ADP B-O
+hicsupport@dundee.ac.uk X B-O
+) PUNCT B-O
+with ADP B-O
+the DET B-O
+HIC PROPN B-AC
+Safe PROPN B-O
+Haven PROPN B-O
+for ADP B-O
+researchers NOUN B-O
+who PRON B-O
+meet VERB B-O
+the DET B-O
+criteria NOUN B-O
+for ADP B-O
+access NOUN B-O
+to ADP B-O
+confidential ADJ B-O
+data NOUN B-O
+and CCONJ B-O
+subject ADJ B-O
+to ADP B-O
+a DET B-O
+data NOUN B-O
+access NOUN B-O
+fee NOUN B-O
+. PUNCT B-O
+
+Indeed ADV B-O
+, PUNCT B-O
+we PRON B-O
+found VERB B-O
+that SCONJ B-O
+sperm NOUN B-O
+enter VERB B-O
+preferentially ADV B-O
+into ADP B-O
+the DET B-O
+polar ADJ B-LF
+body NOUN I-LF
+( PUNCT B-O
+pb PROPN B-AC
+) PUNCT B-O
+half NOUN B-O
+, PUNCT B-O
+except SCONJ B-O
+for ADP B-O
+the DET B-O
+microvilli NOUN B-O
+- ADJ B-O
+free ADJ B-O
+area NOUN B-O
+directly ADV B-O
+above ADP B-O
+the DET B-O
+metaphase NOUN B-O
+chromosomes NOUN B-O
+[ PUNCT B-O
+11 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+whereas SCONJ B-O
+an DET B-O
+earlier ADJ B-O
+study NOUN B-O
+reported VERB B-O
+that SCONJ B-O
+more ADJ B-O
+sperm NOUN B-O
+enter VERB B-O
+in ADP B-O
+the DET B-O
+“ PUNCT B-O
+vegetal ADJ B-O
+” PUNCT B-O
+area NOUN B-O
+[ PUNCT B-O
+10 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+WGV PROPN B-AC
+; PUNCT B-O
+weight NOUN B-LF
+growth NOUN I-LF
+velocity NOUN I-LF
+, PUNCT B-O
+SD PROPN B-AC
+; PUNCT B-O
+standard ADJ B-LF
+deviation NOUN I-LF
+, PUNCT B-O
+PROM PROPN B-AC
+; PUNCT B-O
+preterm ADJ B-LF
+rupture NOUN I-LF
+of ADP I-LF
+membrane NOUN I-LF
+, PUNCT B-O
+SGA PROPN B-AC
+; PUNCT B-O
+small ADJ B-LF
+for ADP I-LF
+gestational ADJ I-LF
+age NOUN I-LF
+, PUNCT B-O
+AS PROPN B-AC
+; PUNCT B-O
+Apgar PROPN B-LF
+score NOUN I-LF
+, PUNCT B-O
+RDS PROPN B-AC
+; PUNCT B-O
+respiratory ADJ B-LF
+distress NOUN I-LF
+syndrome NOUN I-LF
+, PUNCT B-O
+CLD PROPN B-AC
+; PUNCT B-O
+chronic ADJ B-LF
+lung NOUN I-LF
+disease NOUN I-LF
+, PUNCT B-O
+PDA PROPN B-AC
+; PUNCT B-O
+patent NOUN B-LF
+ductus NOUN I-LF
+arteriosus NOUN I-LF
+, PUNCT B-O
+NEC PROPN B-AC
+; PUNCT B-O
+necrotizing VERB B-LF
+enterocolitis NOUN I-LF
+, PUNCT B-O
+IVH PROPN B-AC
+; PUNCT B-O
+intraventricular ADJ B-LF
+hemorrhage NOUN I-LF
+. PUNCT B-O
+
+Other ADJ B-O
+information NOUN B-O
+available ADJ B-O
+in ADP B-O
+MMBNT PROPN B-AC
+’s PART B-O
+dataset NOUN B-O
+includes VERB B-O
+: PUNCT B-O
+Donor PROPN B-O
+ID PROPN B-O
+, PUNCT B-O
+Baby PROPN B-O
+Date NOUN B-LF
+of ADP I-LF
+Birth PROPN I-LF
+( PUNCT B-O
+DOB PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Baby PROPN B-O
+Term PROPN B-O
+( PUNCT B-O
+full ADJ B-O
+term NOUN B-O
+, PUNCT B-O
+preterm ADJ B-O
+, PUNCT B-O
+or CCONJ B-O
+deceased ADJ B-O
+) PUNCT B-O
+, PUNCT B-O
+Deposit NOUN B-O
+Receipt PROPN B-O
+Date NOUN B-O
+, PUNCT B-O
+Deposit NOUN B-O
+Expiration NOUN B-O
+Date NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+Deposit NOUN B-O
+Volume NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+care NOUN B-O
+provided VERB B-O
+by ADP B-O
+skilled ADJ B-O
+health NOUN B-O
+care NOUN B-O
+professionals NOUN B-O
+to PART B-O
+pregnant ADJ B-O
+women NOUN B-O
+and CCONJ B-O
+adolescent ADJ B-O
+girls NOUN B-O
+in ADP B-O
+order NOUN B-O
+to PART B-O
+ensure VERB B-O
+the DET B-O
+best ADJ B-O
+health NOUN B-O
+conditions NOUN B-O
+for ADP B-O
+both CCONJ B-O
+mother NOUN B-O
+and CCONJ B-O
+baby NOUN B-O
+during ADP B-O
+pregnancy NOUN B-O
+is AUX B-O
+considered VERB B-O
+Antenatal ADJ B-LF
+care NOUN I-LF
+( PUNCT B-O
+ANC PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Tau PROPN B-O
+belongs VERB B-O
+to ADP B-O
+the DET B-O
+class NOUN B-O
+of ADP B-O
+natively ADV B-O
+unfolded VERB B-O
+proteins NOUN B-O
+, PUNCT B-O
+binds VERB B-O
+to ADP B-O
+and CCONJ B-O
+stabilizes VERB B-O
+microtubules NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+partially ADV B-O
+folds VERB B-O
+into ADP B-O
+an DET B-O
+ordered ADJ B-O
+β PUNCT B-O
+- NOUN B-O
+structure NOUN B-O
+during NOUN B-O
+aggregation NOUN B-O
+to ADP B-O
+Alzheimer PROPN B-O
+paired VERB B-LF
+helical ADJ I-LF
+filaments NOUN I-LF
+( PUNCT B-O
+PHFs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+insoluble ADJ B-O
+pellet NOUN B-O
+or CCONJ B-O
+acid NOUN B-LF
+insoluble ADJ I-LF
+matrix NOUN I-LF
+( PUNCT B-O
+AIM PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+washed VERB B-O
+with ADP B-O
+MilliQ PROPN B-O
+water NOUN B-O
+several ADJ B-O
+times NOUN B-O
+. PUNCT B-O
+
+Our PRON B-O
+ongoing ADJ B-O
+investigations NOUN B-O
+and CCONJ B-O
+recently ADV B-O
+published VERB B-O
+reports NOUN B-O
+indicated VERB B-O
+that SCONJ B-O
+IV NOUN B-O
+formulation NOUN B-O
+of ADP B-O
+HET0016 PROPN B-O
+with ADP B-O
+2 NUM B-LF
+- PUNCT I-LF
+Hydroxypropyl NOUN I-LF
+Beta PROPN I-LF
+Cyclodextrin PROPN I-LF
+( PUNCT B-O
+HPßCD PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+HPßCD PROPN B-AC
+- PUNCT B-O
+HET0016 PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+20 PROPN B-AC
+synthesis NOUN B-O
+inhibitor NOUN B-O
+, PUNCT B-O
+not PART B-O
+only ADV B-O
+decreased VERB B-O
+the DET B-O
+tumor NOUN B-O
+size NOUN B-O
+but CCONJ B-O
+also ADV B-O
+inhibited VERB B-O
+the DET B-O
+invasiveness NOUN B-O
+of ADP B-O
+these DET B-O
+cancer NOUN B-O
+cells NOUN B-O
+in ADP B-O
+animal NOUN B-O
+models NOUN B-O
+of ADP B-O
+human ADJ B-O
+glioma NOUN B-O
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+consistent ADJ B-O
+with ADP B-O
+the DET B-O
+recruitment NOUN B-O
+of ADP B-O
+attention NOUN B-O
+, PUNCT B-O
+functional ADJ B-LF
+MRI NOUN I-LF
+( PUNCT B-O
+fMRI PROPN B-AC
+) PUNCT B-O
+analyses NOUN B-O
+of ADP B-O
+late ADJ B-O
+learning NOUN B-O
+stages NOUN B-O
+showed VERB B-O
+left ADJ B-O
+parietal ADJ B-O
+activity NOUN B-O
+within ADP B-O
+a DET B-O
+broad ADJ B-O
+bilateral ADJ B-O
+dorsal ADJ B-O
+frontoparietal ADJ B-O
+network NOUN B-O
+. PUNCT B-O
+
+Body NOUN B-LF
+surface NOUN I-LF
+area NOUN I-LF
+( PUNCT B-O
+BSA PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+calculated VERB B-O
+using VERB B-O
+the DET B-O
+formula NOUN B-O
+: PUNCT B-O
+0.0001 NUM B-O
+x NOUN B-O
+71.84 NUM B-O
+x NOUN B-O
+( PUNCT B-O
+weight NOUN B-O
+[ PUNCT B-O
+kg])0.425 NUM B-O
+x NOUN B-O
+( PUNCT B-O
+height NOUN B-O
+[ PUNCT B-O
+cm])0.725 NUM B-O
+. PUNCT B-O
+
+The DET B-O
+PMTCT PROPN B-LF
+Effectiveness PROPN I-LF
+PMTCT PROPN B-AC
+in ADP I-LF
+Africa PROPN I-LF
+: PUNCT I-LF
+Research PROPN I-LF
+and CCONJ I-LF
+Linkages PROPN I-LF
+to ADP I-LF
+Care PROPN I-LF
+Study PROPN I-LF
+( PUNCT B-O
+PEARLStudy PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+a DET B-O
+multi ADJ B-O
+- ADJ B-O
+country ADJ B-O
+evaluation NOUN B-O
+of ADP B-O
+the DET B-O
+effectiveness NOUN B-O
+of ADP B-O
+PMTCT PROPN B-AC
+services NOUN B-O
+at ADP B-O
+the DET B-O
+community NOUN B-O
+and CCONJ B-O
+facility NOUN B-O
+level NOUN B-O
+. PUNCT B-O
+
+R NOUN B-O
+- PUNCT B-O
+loops NOUN B-O
+can AUX B-O
+recruit VERB B-O
+their PRON B-O
+reader NOUN B-O
+( PUNCT B-O
+growth NOUN B-LF
+arrest NOUN I-LF
+and CCONJ I-LF
+DNA NOUN I-LF
+damage NOUN I-LF
+protein NOUN I-LF
+45A NOUN I-LF
+[ PUNCT B-O
+GADD45A PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+to PART B-O
+promote VERB B-O
+the DET B-O
+demethylation NOUN B-O
+pathway NOUN B-O
+at ADP B-O
+promoter NOUN B-O
+cytosine NOUN B-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+- PUNCT I-LF
+guanine NOUN I-LF
+( PUNCT B-O
+CpG PROPN B-AC
+) PUNCT B-O
+islands NOUN B-O
+in ADP B-O
+human ADJ B-O
+cells NOUN B-O
+[ PUNCT B-O
+44 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+utilized VERB B-O
+multiple ADJ B-O
+publicly ADV B-O
+available ADJ B-O
+data NOUN B-O
+sources NOUN B-O
+to PART B-O
+evaluate VERB B-O
+the DET B-O
+association NOUN B-O
+between ADP B-O
+introduction NOUN B-O
+of ADP B-O
+PMI PROPN B-AC
+and CCONJ B-O
+child NOUN B-O
+mortality NOUN B-O
+rates NOUN B-O
+in ADP B-O
+sub ADJ B-LF
+- ADJ I-LF
+Saharan ADJ I-LF
+Africa PROPN I-LF
+( PUNCT B-O
+SSA PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+test VERB B-O
+whether SCONJ B-O
+hemoglobin NOUN B-O
+levels NOUN B-O
+were AUX B-O
+significantly ADV B-O
+different ADJ B-O
+between ADP B-O
+the DET B-O
+groups NOUN B-O
+we PRON B-O
+used VERB B-O
+a DET B-O
+mixed VERB B-O
+linear ADJ B-O
+model NOUN B-O
+that PRON B-O
+adjusts VERB B-O
+for ADP B-O
+repeated VERB B-O
+measures NOUN B-O
+over ADP B-O
+the DET B-O
+period NOUN B-O
+of ADP B-O
+observation NOUN B-O
+and CCONJ B-O
+also ADV B-O
+adjusts VERB B-O
+for ADP B-O
+coinfections NOUN B-O
+with ADP B-O
+schistosomiasis NOUN B-O
+, PUNCT B-O
+lymphatic ADJ B-O
+filariasis NOUN B-O
+and/or CCONJ B-O
+hookworm NOUN B-O
+, PUNCT B-O
+as ADP B-O
+well ADV B-O
+as ADP B-O
+height NOUN B-O
+and CCONJ B-O
+weight NOUN B-O
+measurements NOUN B-O
+( PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+[ PUNCT B-O
+BMI PROPN B-AC
+] PUNCT B-O
+, PUNCT B-O
+a DET B-O
+surrogate NOUN B-O
+for ADP B-O
+nutritional ADJ B-O
+status NOUN B-O
+) PUNCT B-O
+from ADP B-O
+each DET B-O
+follow NOUN B-O
+- PUNCT B-O
+up NOUN B-O
+. PUNCT B-O
+
+CD59 NOUN B-O
+is AUX B-O
+a DET B-O
+membrane NOUN B-O
+complement NOUN B-O
+regulatory ADJ B-O
+protein NOUN B-O
+that PRON B-O
+is AUX B-O
+attached VERB B-O
+to ADP B-O
+the DET B-O
+cell NOUN B-O
+membrane NOUN B-O
+via ADP B-O
+a DET B-O
+glycosylphosphatidylinositol NOUN B-LF
+( PUNCT B-O
+GPI PROPN B-AC
+) PUNCT B-O
+anchor NOUN B-O
+. PUNCT B-O
+
+Leptin NOUN B-O
+receptors NOUN B-O
+have AUX B-O
+been AUX B-O
+found VERB B-O
+on ADP B-O
+paraventricular ADJ B-LF
+nucleus NOUN I-LF
+( PUNCT B-O
+PVN PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+lateral ADJ B-LF
+hypothalamic ADJ I-LF
+( PUNCT B-O
+LHA PROPN B-AC
+) PUNCT B-O
+neurons NOUN B-O
+, PUNCT B-O
+implicating VERB B-O
+them PRON B-O
+as ADP B-O
+direct ADJ B-O
+targets NOUN B-O
+for ADP B-O
+regulation NOUN B-O
+by ADP B-O
+circulating VERB B-O
+adiposity NOUN B-O
+signals NOUN B-O
+. PUNCT B-O
+
+Cadmium NOUN B-LF
+( PUNCT B-O
+Cd PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+developmental ADJ B-O
+toxicant NOUN B-O
+that PRON B-O
+induces VERB B-O
+fetal ADJ B-LF
+growth NOUN I-LF
+restriction NOUN I-LF
+( PUNCT B-O
+FGR PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Placental ADJ B-O
+endoplasmic ADJ B-O
+reticulum NOUN B-O
+( PUNCT B-O
+ER PROPN B-O
+) PUNCT B-O
+stress NOUN B-O
+is AUX B-O
+associated VERB B-O
+with ADP B-O
+FGR PROPN B-AC
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+investigated VERB B-O
+the DET B-O
+effects NOUN B-O
+of ADP B-O
+N NOUN B-LF
+- PUNCT I-LF
+acetylcysteine NOUN I-LF
+( PUNCT B-O
+NAC PROPN B-AC
+) PUNCT B-O
+on ADP B-O
+Cd PROPN B-AC
+- PUNCT B-O
+induced VERB B-O
+placental ADJ B-O
+ER PROPN B-AC
+and CCONJ B-O
+stressFGR PROPN B-AC
+. PUNCT B-O
+
+Pregnant ADJ B-O
+mice NOUN B-O
+were AUX B-O
+intraperitoneally ADV B-O
+injected VERB B-O
+with ADP B-O
+CdCl2 PROPN B-O
+daily ADV B-O
+from ADP B-O
+gestational ADJ B-LF
+day NOUN I-LF
+( PUNCT B-O
+GD)13 PROPN B-AC
+to ADP B-O
+GD17 NUM B-O
+. PUNCT B-O
+
+Reviewer#2 NOUN B-O
+: PUNCT B-O
+This DET B-O
+manuscript NOUN B-O
+describes VERB B-O
+a DET B-O
+novel ADJ B-O
+matrix NOUN B-LF
+- PUNCT I-LF
+assisted VERB I-LF
+laser NOUN I-LF
+desorption NOUN I-LF
+/ SYM I-LF
+ionization NOUN I-LF
+time NOUN I-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+flight NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT B-O
+MALDI-TOF-MS PROPN B-AC
+) PUNCT B-O
+analysis NOUN B-O
+of ADP B-O
+the DET B-O
+extracted VERB B-O
+peptides NOUN B-O
+obtained VERB B-O
+from ADP B-O
+Streptococcus PROPN B-O
+suis PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+particularly ADV B-O
+S. PROPN B-O
+suis PROPN B-O
+serotype NOUN B-O
+( PUNCT B-O
+SS2 NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Replicated VERB B-O
+hybridisation NOUN B-O
+to ADP B-O
+genomic ADJ B-O
+DNA NOUN B-O
+tiling NOUN B-O
+arrays NOUN B-O
+generated VERB B-O
+a DET B-O
+dataset NOUN B-O
+( PUNCT B-O
+Dataset PROPN B-O
+S1 PROPN B-O
+) PUNCT B-O
+with ADP B-O
+mean ADJ B-LF
+enrichments NOUN I-LF
+( PUNCT B-O
+Mn PROPN B-AC
+) PUNCT B-O
+equivalent ADJ B-O
+to ADP B-O
+log2 NUM B-O
+3.8 NUM B-O
+( PUNCT B-O
+14 NUM B-O
+- ADJ B-O
+fold ADJ B-O
+) PUNCT B-O
+observed VERB B-O
+. PUNCT B-O
+
+Therefore ADV B-O
+, PUNCT B-O
+our PRON B-O
+estimates NOUN B-O
+at ADP B-O
+such ADJ B-O
+high ADJ B-O
+thresholds NOUN B-O
+might AUX B-O
+be AUX B-O
+approximately ADV B-O
+correct ADJ B-O
+; PUNCT B-O
+if SCONJ B-O
+so ADV B-O
+, PUNCT B-O
+the DET B-O
+accuracy NOUN B-O
+of ADP B-O
+homology NOUN B-O
+transfer NOUN B-O
+for ADP B-O
+high ADJ B-O
+similarity NOUN B-O
+( PUNCT B-O
+HVAL PROPN B-AC
+> SYM B-O
+40 NUM B-O
+, PUNCT B-O
+Percentage NOUN B-LF
+sequence NOUN I-LF
+IDEntity NOUN I-LF
+( PUNCT B-O
+PIDE PROPN B-AC
+) PUNCT B-O
+> SYM B-O
+70 NUM B-O
+) PUNCT B-O
+were AUX B-O
+just ADV B-O
+over ADP B-O
+10 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+2 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+FGC PROPN B-AC
+, PUNCT B-O
+female ADJ B-LF
+genital ADJ I-LF
+cutting NOUN I-LF
+; PUNCT B-O
+MoH PROPN B-AC
+, PUNCT B-O
+Ministry PROPN B-LF
+of ADP I-LF
+Health PROPN I-LF
+However ADV B-O
+, PUNCT B-O
+type NOUN B-O
+D NOUN B-O
+is AUX B-O
+a DET B-O
+limited ADJ B-O
+and CCONJ B-O
+specific ADJ B-O
+aspect NOUN B-O
+of ADP B-O
+personality NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+currently ADV B-O
+the DET B-O
+Five NUM B-LF
+Factor PROPN I-LF
+Model PROPN I-LF
+( PUNCT B-O
+FFM PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+more ADV B-O
+accepted ADJ B-O
+, PUNCT B-O
+widely ADV B-O
+used VERB B-O
+and CCONJ B-O
+comprehensive ADJ B-O
+means NOUN B-O
+of ADP B-O
+categorization NOUN B-O
+[ PUNCT B-O
+21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+presence NOUN B-O
+of ADP B-O
+ITPase PROPN B-AC
+deficiency NOUN B-O
+was AUX B-O
+not PART B-O
+statistically ADV B-O
+associated VERB B-O
+with ADP B-O
+a DET B-O
+lower ADJ B-O
+hazard NOUN B-LF
+ratio NOUN I-LF
+( PUNCT B-O
+HR PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+RBV PROPN B-AC
+dose NOUN B-O
+reductions NOUN B-O
+( PUNCT B-O
+HR PROPN B-AC
+0.80 NUM B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+0.35–1.71 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.57 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+BMP PROPN B-AC
+, PUNCT B-O
+Bone PROPN B-LF
+Morphogenetic PROPN I-LF
+Protein PROPN I-LF
+; PUNCT B-O
+FISH PROPN B-AC
+, PUNCT B-O
+fluorescent ADJ B-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+; PUNCT B-O
+hpf PROPN B-AC
+, PUNCT B-O
+hours NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+; PUNCT B-O
+pSmad5 PROPN B-AC
+, PUNCT B-O
+phosphorylated VERB B-LF
+Smad5 NOUN I-LF
+; PUNCT B-O
+WT PROPN B-O
+, PUNCT B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+. PUNCT B-O
+
+NF-κB PROPN B-AC
+dimers NOUN B-O
+are AUX B-O
+sequestered VERB B-O
+in ADP B-O
+the DET B-O
+cytoplasm NOUN B-O
+by ADP B-O
+an DET B-O
+inhibitory ADJ B-O
+protein NOUN B-O
+IκBα PROPN B-O
+, PUNCT B-O
+which PRON B-O
+masks VERB B-O
+the DET B-O
+conserved VERB B-O
+nuclear ADJ B-LF
+localization NOUN I-LF
+sequence NOUN I-LF
+( PUNCT B-O
+NLS PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+RelA PROPN B-O
+/ SYM B-O
+p65 NOUN B-O
+to PART B-O
+prevent VERB B-O
+nuclear ADJ B-O
+translocation NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+AMPK PROPN B-AC
+, PUNCT B-O
+AMP NOUN B-O
+- PUNCT B-O
+activated VERB B-O
+protein NOUN B-O
+kinase NOUN B-O
+; PUNCT B-O
+AUC PROPN B-AC
+, PUNCT B-O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+; PUNCT B-O
+Glut2 PROPN B-AC
+, PUNCT B-O
+glucose NOUN B-LF
+transporter NOUN I-LF
+2 NUM I-LF
+; PUNCT B-O
+GTT PROPN B-AC
+, PUNCT B-O
+glucose NOUN B-LF
+tolerance NOUN I-LF
+test NOUN I-LF
+; PUNCT B-O
+GS PROPN B-AC
+, PUNCT B-O
+glycogen NOUN B-LF
+synthase NOUN I-LF
+; PUNCT B-O
+GS PROPN B-AC
+- PUNCT B-O
+p641 NOUN B-O
+, PUNCT B-O
+phospho NOUN B-O
+- PUNCT B-O
+glycogen NOUN B-LF
+synthase NOUN I-LF
+at ADP B-O
+S641 NUM B-O
+; PUNCT B-O
+ITT PROPN B-AC
+, PUNCT B-O
+insulin NOUN B-LF
+tolerance NOUN I-LF
+test NOUN I-LF
+; PUNCT B-O
+Oct1 PROPN B-O
+, PUNCT B-O
+organic ADJ B-O
+cation NOUN B-O
+transporter NOUN B-O
+1 NUM B-O
+; PUNCT B-O
+pACC NOUN B-O
+, PUNCT B-O
+phosphorylate NOUN B-O
+acetyl NOUN B-O
+- PUNCT B-O
+CoA NOUN B-O
+carboxylase NOUN B-O
+; PUNCT B-O
+pAMPK PROPN B-O
+, PUNCT B-O
+phosphorylate NOUN B-O
+5 NUM B-O
+' NOUN B-O
+adenosine NOUN B-O
+monophosphate NOUN B-O
+- PUNCT B-O
+activated VERB B-O
+protein NOUN B-O
+kinase NOUN B-O
+; PUNCT B-O
+PDH PROPN B-AC
+, PUNCT B-O
+pyruvate NOUN B-LF
+dehydrogenase NOUN I-LF
+; PUNCT B-O
+PDH PROPN B-AC
+- PUNCT B-O
+p NOUN B-O
+, PUNCT B-O
+phospho NOUN B-O
+- PUNCT B-O
+pyruvate NOUN B-LF
+dehydrogenase NOUN I-LF
+; PUNCT B-O
+PTT PROPN B-AC
+, PUNCT B-O
+pyruvate NOUN B-LF
+tolerance NOUN I-LF
+test NOUN I-LF
+; PUNCT B-O
+PYGL PROPN B-AC
+; PUNCT B-O
+glycogen NOUN B-LF
+phosphorylase NOUN I-LF
+. PUNCT B-O
+
+Using VERB B-O
+ChIP-qPCR PROPN B-AC
+, PUNCT B-O
+we PRON B-O
+analysed VERB B-O
+levels NOUN B-O
+of ADP B-O
+the DET B-O
+active ADJ B-O
+- PUNCT B-O
+promoter NOUN B-O
+– PUNCT B-O
+associated VERB B-O
+H3K4Me3 PROPN B-AC
+mark NOUN B-O
+and CCONJ B-O
+the DET B-O
+polycomb NOUN B-LF
+repressor NOUN I-LF
+complex NOUN I-LF
+( PUNCT B-O
+PRC)-associated PROPN B-AC
+repressive ADJ B-O
+H3K27Me3 PROPN B-AC
+mark NOUN B-O
+across ADP B-O
+the DET B-O
+HPV18 PROPN B-O
+genome NOUN B-O
+. PUNCT B-O
+
+Criteria NOUN B-O
+for ADP B-O
+discharge NOUN B-O
+were AUX B-O
+the DET B-O
+absence NOUN B-O
+of ADP B-O
+fever NOUN B-O
+and CCONJ B-O
+significant ADJ B-O
+symptoms NOUN B-O
+for ADP B-O
+four NUM B-O
+consecutive ADJ B-O
+days NOUN B-O
+, PUNCT B-O
+ability NOUN B-O
+to PART B-O
+feed VERB B-O
+and CCONJ B-O
+walk VERB B-O
+independently ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+two NUM B-O
+consecutive ADJ B-O
+negative ADJ B-O
+blood NOUN B-O
+reverse ADJ B-LF
+EBOV PROPN B-AC
+transcription NOUN I-LF
+PCR NOUN I-LF
+( PUNCT B-O
+RT PROPN B-AC
+) PUNCT B-O
+tests NOUN B-O
+. PUNCT B-O
+
+p NOUN B-LF
+- NOUN I-LF
+p PROPN B-AC
+value NOUN I-LF
+Statistical PROPN B-LF
+Package PROPN I-LF
+for ADP I-LF
+the DET I-LF
+Social PROPN I-LF
+Sciences PROPN I-LF
+( PUNCT B-O
+SPSS PROPN B-AC
+17.0 NUM B-O
+) PUNCT B-O
+was AUX B-O
+used VERB B-O
+for ADP B-O
+all DET B-O
+analyses NOUN B-O
+. PUNCT B-O
+
+Length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+( PUNCT B-O
+LOS PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+calculated VERB B-O
+as ADP B-O
+the DET B-O
+time NOUN B-O
+the DET B-O
+disposition NOUN B-O
+was AUX B-O
+set VERB B-O
+to ADP B-O
+admit VERB B-O
+to ADP B-O
+the DET B-O
+time NOUN B-O
+the DET B-O
+subject NOUN B-O
+met VERB B-O
+the DET B-O
+clinical ADJ B-O
+criteria NOUN B-O
+for ADP B-O
+discharge NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+order NOUN B-O
+to PART B-O
+define VERB B-O
+a DET B-O
+putative ADJ B-O
+olfactory ADJ B-O
+space NOUN B-O
+for ADP B-O
+the DET B-O
+honeybee NOUN B-O
+, PUNCT B-O
+we PRON B-O
+performed VERB B-O
+a DET B-O
+principal ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+( PUNCT B-O
+PCA PROPN B-AC
+) PUNCT B-O
+on ADP B-O
+our PRON B-O
+data NOUN B-O
+to PART B-O
+represent VERB B-O
+in ADP B-O
+a DET B-O
+limited ADJ B-O
+number NOUN B-O
+of ADP B-O
+dimensions NOUN B-O
+the DET B-O
+relative ADJ B-O
+relationships NOUN B-O
+between ADP B-O
+odorants NOUN B-O
+in ADP B-O
+a DET B-O
+16 NUM B-O
+- PUNCT B-O
+dimension NOUN B-O
+perceptual ADJ B-O
+space NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+6A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+first ADJ B-O
+three NUM B-O
+factors NOUN B-O
+represented VERB B-O
+31 NUM B-O
+% PUNCT B-O
+, PUNCT B-O
+29 NUM B-O
+% PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+15 NUM B-O
+% PUNCT B-O
+of ADP B-O
+overall ADJ B-O
+variance NOUN B-O
+in ADP B-O
+the DET B-O
+data NOUN B-O
+( PUNCT B-O
+total NOUN B-O
+of ADP B-O
+the DET B-O
+first ADJ B-O
+three NUM B-O
+factors NOUN B-O
+: PUNCT B-O
+75 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+HIV PROPN B-O
+epidemic NOUN B-O
+is AUX B-O
+rapidly ADV B-O
+growing VERB B-O
+among ADP B-O
+men NOUN B-LF
+who PRON I-LF
+have VERB I-LF
+sex NOUN I-LF
+with ADP I-LF
+men NOUN I-LF
+( PUNCT B-O
+MSM PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+China PROPN B-O
+, PUNCT B-O
+yet CCONJ B-O
+HIV PROPN B-O
+testing NOUN B-O
+remains VERB B-O
+suboptimal ADJ B-O
+. PUNCT B-O
+
+Quality NOUN B-LF
+of ADP I-LF
+care NOUN I-LF
+was AUX B-O
+assessed VERB B-O
+using VERB B-O
+context NOUN B-O
+based VERB B-O
+validated VERB B-O
+indicators NOUN B-O
+which PRON B-O
+provide VERB B-O
+a DET B-O
+more ADV B-O
+detailed ADJ B-O
+picture NOUN B-O
+of ADP B-O
+the DET B-O
+state NOUN B-O
+of ADP B-O
+QoC PROPN B-AC
+in ADP B-O
+the DET B-O
+process NOUN B-O
+of ADP B-O
+childbirth NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+understand VERB B-O
+the DET B-O
+source NOUN B-O
+of ADP B-O
+ROS PROPN B-AC
+and CCONJ B-O
+to PART B-O
+determine VERB B-O
+the DET B-O
+association NOUN B-O
+of ADP B-O
+AngII PROPN B-AC
+signaling NOUN B-O
+, PUNCT B-O
+Klf5 PROPN B-AC
+, PUNCT B-O
+and CCONJ B-O
+eIF5α NOUN B-O
+with ADP B-O
+NOX PROPN B-AC
+expression NOUN B-O
+, PUNCT B-O
+mouse NOUN B-O
+VSMCs PROPN B-AC
+were AUX B-O
+transfected VERB B-O
+with ADP B-O
+expression NOUN B-O
+vectors NOUN B-O
+for ADP B-O
+Klf5 PROPN B-AC
+and CCONJ B-O
+eIF5α NOUN B-O
+or CCONJ B-O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+( PUNCT B-O
+siRNA PROPN B-AC
+) PUNCT B-O
+against ADP B-O
+Klf5 PROPN B-AC
+and CCONJ B-O
+eIF5α NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+then ADV B-O
+treated VERB B-O
+with ADP B-O
+Ang PROPN B-AC
+for ADP B-O
+0 NUM B-O
+, PUNCT B-O
+1 NUM B-O
+, PUNCT B-O
+3 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+5 NUM B-O
+days NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+expression NOUN B-O
+of ADP B-O
+NOX1 NOUN B-O
+and CCONJ B-O
+NOX4 NOUN B-O
+was AUX B-O
+detected VERB B-O
+by ADP B-O
+RT NOUN B-O
+- PUNCT B-O
+qPCR NOUN B-O
+. PUNCT B-O
+
+As SCONJ B-O
+shown VERB B-O
+in ADP B-O
+S17A PROPN B-O
+– PUNCT B-O
+S17D PROPN B-O
+Fig PROPN B-O
+, PUNCT B-O
+IIAng PROPN B-AC
+treatment NOUN B-O
+increased VERB B-O
+NOX1 NOUN B-O
+expression NOUN B-O
+, PUNCT B-O
+peaked VERB B-O
+at ADP B-O
+24 NUM B-O
+hours NOUN B-O
+after ADP B-O
+treatment NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+gradually ADV B-O
+declined VERB B-O
+thereafter ADV B-O
+. PUNCT B-O
+
+terminal ADJ B-LF
+λz PROPN B-AC
+slope NOUN I-LF
+; PUNCT B-O
+AUC0-∞ NOUN B-O
+area NOUN B-O
+under ADP B-O
+the DET B-O
+curve NOUN B-O
+from ADP B-O
+0 NUM B-O
+to ADP B-O
+infinitive ADJ B-O
+; PUNCT B-O
+mean ADJ B-LF
+MTT PROPN B-AC
+transit NOUN I-LF
+time NOUN I-LF
+; PUNCT B-O
+Tmax PROPN B-AC
+time NOUN B-O
+at ADP B-O
+maximum ADJ B-LF
+concentration NOUN I-LF
+; PUNCT B-O
+maximum ADJ B-LF
+Cmax PROPN B-AC
+concentration NOUN I-LF
+; PUNCT B-O
+F NOUN B-O
+bioavailability NOUN B-O
+, PUNCT B-O
+was AUX B-O
+calculated VERB B-O
+by ADP B-O
+dividing VERB B-O
+the DET B-O
+ratio NOUN B-O
+of ADP B-O
+AUC0-∞ NOUN B-O
+oral ADJ B-O
+by ADP B-O
+the DET B-O
+dose NOUN B-O
+and CCONJ B-O
+by ADP B-O
+ratio NOUN B-O
+total ADJ B-O
+PTA PROPN B-AC
+AUC0-∞ NOUN B-O
+IV NOUN B-O
+by ADP B-O
+respective ADJ B-O
+dose NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+figure NOUN B-O
+illustrates VERB B-O
+ErbB PROPN B-O
+signaling NOUN B-O
+pathway NOUN B-O
+that PRON B-O
+contain VERB B-O
+genes NOUN B-O
+that PRON B-O
+are AUX B-O
+targeted VERB B-O
+by ADP B-O
+miRNAs PROPN B-AC
+which PRON B-O
+regulate VERB B-O
+NMT PROPN B-AC
+gene NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+EGF PROPN B-O
+, PUNCT B-O
+epidermal ADJ B-O
+growth NOUN B-O
+factor NOUN B-O
+; PUNCT B-O
+TGF PROPN B-O
+, PUNCT B-O
+transforming VERB B-O
+growth NOUN B-O
+factor NOUN B-O
+; PUNCT B-O
+BTC PROPN B-O
+, PUNCT B-O
+betacellulin NOUN B-O
+; PUNCT B-O
+HB PROPN B-O
+- PUNCT B-O
+EGF PROPN B-O
+, PUNCT B-O
+heparin NOUN B-O
+- PUNCT B-O
+binding VERB B-O
+epidermal ADJ B-O
+growth NOUN B-O
+factor NOUN B-O
+( PUNCT B-O
+EGF)-like PROPN B-O
+growth NOUN B-O
+factor NOUN B-O
+; PUNCT B-O
+EREG PROPN B-O
+, PUNCT B-O
+epiregulin NOUN B-O
+; PUNCT B-O
+NRG1 PROPN B-O
+, PUNCT B-O
+neuregulin-1 NOUN B-O
+; PUNCT B-O
+NRG2 PROPN B-O
+, PUNCT B-O
+neuregulin-2 NOUN B-O
+; PUNCT B-O
+NRG3 PROPN B-O
+, PUNCT B-O
+neuregulin-3 NOUN B-O
+; PUNCT B-O
+NRG4 PROPN B-O
+, PUNCT B-O
+neuregulin-4 NOUN B-O
+; PUNCT B-O
+PLCγ PROPN B-O
+, PUNCT B-O
+phospholipase NOUN B-O
+C PROPN B-O
+type NOUN B-O
+gamma NOUN B-O
+; PUNCT B-O
+CAMK2B PROPN B-O
+, PUNCT B-O
+calcium NOUN B-O
+/ SYM B-O
+calmodulin NOUN B-O
+dependent ADJ B-O
+protein NOUN B-O
+kinase NOUN B-O
+; PUNCT B-O
+PRKCB PROPN B-O
+, PUNCT B-O
+Protein PROPN B-O
+kinase NOUN B-O
+C PROPN B-O
+- PUNCT B-O
+beta NOUN B-O
+; PUNCT B-O
+STAT5 PROPN B-O
+, PUNCT B-O
+Signal NOUN B-O
+transducer NOUN B-O
+and CCONJ B-O
+activator NOUN B-O
+of ADP B-O
+transcription NOUN B-O
+5 NUM B-O
+; PUNCT B-O
+src PROPN B-O
+, PUNCT B-O
+Rous PROPN B-O
+sarcoma NOUN B-O
+virus NOUN B-O
+gene NOUN B-O
+; PUNCT B-O
+CRK PROPN B-O
+, PUNCT B-O
+C PROPN B-O
+T10 NOUN B-O
+regulator NOUN B-O
+of ADP B-O
+a DET B-O
+tyrosine NOUN B-O
+kinase NOUN B-O
+; PUNCT B-O
+NCL PROPN B-O
+, PUNCT B-O
+NCK PROPN B-O
+Adaptor PROPN B-O
+Protein PROPN B-O
+2 NUM B-O
+; PUNCT B-O
+PTK2 PROPN B-O
+, PUNCT B-O
+PTK2 PROPN B-O
+protein NOUN B-O
+tyrosine NOUN B-O
+kinase NOUN B-O
+2 NUM B-O
+; PUNCT B-O
+ABL2 PROPN B-O
+, PUNCT B-O
+V PROPN B-O
+- PUNCT B-O
+Abl PROPN B-O
+Abelson PROPN B-O
+Murine PROPN B-O
+Leukemia PROPN B-O
+Viral PROPN B-O
+Oncogene PROPN B-O
+Homolog PROPN B-O
+2 NUM B-O
+; PUNCT B-O
+PAK2 PROPN B-O
+, PUNCT B-O
+P21 PROPN B-O
+( PUNCT B-O
+RAC1 PROPN B-O
+) PUNCT B-O
+Activated PROPN B-O
+Kinase PROPN B-O
+2 NUM B-O
+; PUNCT B-O
+MAP2K4 PROPN B-O
+, PUNCT B-O
+Mitogen PROPN B-O
+- PUNCT B-O
+Activated PROPN B-O
+Protein PROPN B-O
+Kinase PROPN B-O
+Kinase PROPN B-O
+4 NUM B-O
+; PUNCT B-O
+MAPK10 PROPN B-O
+, PUNCT B-O
+Mitogen PROPN B-O
+- PUNCT B-O
+Activated PROPN B-O
+Protein PROPN B-O
+Kinase PROPN B-O
+10 NUM B-O
+; PUNCT B-O
+SOS1 PROPN B-O
+, PUNCT B-O
+SOS PROPN B-O
+Ras PROPN B-O
+/ SYM B-O
+Rac NOUN B-O
+Guanine NOUN B-O
+Nucleotide PROPN B-O
+Exchange PROPN B-O
+Factor PROPN B-O
+1 NUM B-O
+; PUNCT B-O
+Grb2 PROPN B-O
+, PUNCT B-O
+Growth NOUN B-O
+Factor PROPN B-O
+Receptor NOUN B-O
+Bound PROPN B-O
+Protein PROPN B-O
+2 NUM B-O
+; PUNCT B-O
+SHC4 PROPN B-O
+, PUNCT B-O
+Src NOUN B-O
+Homology NOUN B-O
+2 NUM B-O
+Domain NOUN B-O
+- PUNCT B-O
+Containing VERB B-O
+- PUNCT B-O
+Transforming VERB B-O
+Protein PROPN B-O
+C4 PROPN B-O
+; PUNCT B-O
+PIK3C4 PROPN B-O
+, PUNCT B-O
+Phosphatidylinositol-4,5 NOUN B-O
+- PUNCT B-O
+Bisphosphate NOUN B-O
+3 NUM B-O
+- PUNCT B-O
+Kinase PROPN B-O
+Catalytic PROPN B-O
+Subunit PROPN B-O
+; PUNCT B-O
+AKT3 PROPN B-O
+, PUNCT B-O
+KT PROPN B-O
+Serine NOUN B-O
+/ SYM B-O
+Threonine NOUN B-O
+Kinase PROPN B-O
+3 NUM B-O
+; PUNCT B-O
+mTOR NOUN B-O
+, PUNCT B-O
+Mechanistic ADJ B-O
+Target NOUN B-O
+Of ADP B-O
+Rapamycin NOUN B-O
+Kinase PROPN B-O
+; PUNCT B-O
+BCL2 PROPN B-O
+, PUNCT B-O
+BCL2 PROPN B-O
+Associated ADJ B-O
+Agonist NOUN B-O
+Of ADP B-O
+Cell NOUN B-O
+Death NOUN B-O
+; PUNCT B-O
+GSK3B PROPN B-AC
+, PUNCT B-O
+Glycogen NOUN B-LF
+Synthase NOUN I-LF
+Kinase PROPN I-LF
+3 NUM I-LF
+Beta PROPN I-LF
+; PUNCT B-O
+CDKN1A PROPN B-O
+, PUNCT B-O
+Cyclin NOUN B-O
+Dependent PROPN B-O
+Kinase PROPN B-O
+Inhibitor PROPN B-O
+1A PROPN B-O
+; PUNCT B-O
+EIF4EBP1 PROPN B-O
+, PUNCT B-O
+Eukaryotic ADJ B-O
+Translation NOUN B-O
+Initiation PROPN B-O
+Factor PROPN B-O
+4E NUM B-O
+Binding PROPN B-O
+Protein PROPN B-O
+1 NUM B-O
+; PUNCT B-O
+BRAF PROPN B-AC
+, PUNCT B-O
+B PROPN B-LF
+- PUNCT I-LF
+Raf PROPN I-LF
+Proto PROPN I-LF
+- PUNCT I-LF
+Oncogene PROPN I-LF
+, PUNCT B-O
+Serine NOUN B-O
+/ SYM B-O
+Threonine NOUN B-O
+Kinase PROPN B-O
+; PUNCT B-O
+RPS6KB1 PROPN B-O
+, PUNCT B-O
+Ribosomal PROPN B-O
+Protein PROPN B-O
+S6 PROPN B-O
+Kinase PROPN B-O
+B1 PROPN B-O
+; PUNCT B-O
+KRAS PROPN B-O
+, PUNCT B-O
+KRAS PROPN B-O
+Proto PROPN B-O
+- PUNCT B-O
+Oncogene PROPN B-O
+, PUNCT B-O
+GTPase PROPN B-O
+; PUNCT B-O
+JUN PROPN B-O
+, PUNCT B-O
+Jun PROPN B-O
+Proto PROPN B-O
+- PUNCT B-O
+Oncogene PROPN B-O
+, PUNCT B-O
+AP-1 PROPN B-O
+Transcription PROPN B-O
+Factor PROPN B-O
+Subunit PROPN B-O
+; PUNCT B-O
+ELK PROPN B-O
+, PUNCT B-O
+ETS PROPN B-O
+Transcription PROPN B-O
+Factor PROPN B-O
+; PUNCT B-O
+Myc PROPN B-O
+, PUNCT B-O
+MYC PROPN B-O
+Proto PROPN B-O
+- PUNCT B-O
+Oncogene PROPN B-O
+, PUNCT B-O
+BHLH PROPN B-O
+Transcription PROPN B-O
+Factor PROPN B-O
+; PUNCT B-O
+ER PROPN B-O
+, PUNCT B-O
+endoplasmic ADJ B-O
+reticulum NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+determine VERB B-O
+whether SCONJ B-O
+such ADJ B-O
+target NOUN B-O
+proteins NOUN B-O
+could AUX B-O
+be AUX B-O
+identified VERB B-O
+for ADP B-O
+Ginir PROPN B-AC
+RNA NOUN B-O
+, PUNCT B-O
+we PRON B-O
+followed VERB B-O
+the DET B-O
+approach NOUN B-O
+of ADP B-O
+using VERB B-O
+biotin NOUN B-O
+- PUNCT B-O
+labelled VERB B-O
+RNA NOUN B-O
+affinity NOUN B-O
+pull VERB B-O
+- PUNCT B-O
+down NOUN B-O
+and CCONJ B-O
+RNA NOUN B-LF
+- PUNCT I-LF
+immunoprecipitation NOUN I-LF
+( PUNCT B-O
+RIP PROPN B-AC
+) PUNCT B-O
+assays NOUN B-O
+. PUNCT B-O
+
+This DET B-O
+hyperphosphorylation NOUN B-O
+causes VERB B-O
+light NOUN B-O
+- PUNCT B-O
+dependent ADJ B-O
+retinal ADJ B-O
+degeneration NOUN B-O
+and CCONJ B-O
+premature ADJ B-O
+entrance NOUN B-O
+into ADP B-O
+the DET B-O
+prolonged VERB B-LF
+depolarizing VERB I-LF
+afterpotential NOUN I-LF
+( PUNCT B-O
+PDA PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+1–3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Sirius PROPN B-O
+red ADJ B-O
+staining NOUN B-O
+revealed VERB B-O
+significantly ADV B-O
+more ADJ B-O
+collagen NOUN B-O
+deposition NOUN B-O
+in ADP B-O
+the DET B-O
+F-BCA PROPN B-AC
+adipose ADJ B-O
+tissues NOUN B-O
+, PUNCT B-O
+particularly ADV B-O
+around ADP B-O
+the DET B-O
+SVF PROPN B-AC
+zones NOUN B-O
+( PUNCT B-O
+Fig NUM B-O
+6A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+More ADV B-O
+abundant ADJ B-O
+type NOUN B-LF
+I NOUN I-LF
+collagen NOUN I-LF
+( PUNCT B-O
+ColI PROPN B-AC
+) PUNCT B-O
+expression NOUN B-O
+was AUX B-O
+detected VERB B-O
+in ADP B-O
+the DET B-O
+F PROPN B-AC
+-BCASVF PROPN B-AC
+cells NOUN B-O
+( PUNCT B-O
+Fig NUM B-O
+6B NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+although SCONJ B-O
+the DET B-O
+mRNA NOUN B-O
+levels NOUN B-O
+were AUX B-O
+unchanged ADJ B-O
+upon SCONJ B-O
+activation NOUN B-O
+of ADP B-O
+canonical ADJ B-O
+Wnt NOUN B-O
+signaling NOUN B-O
+in ADP B-O
+the DET B-O
+FSP1 PROPN B-AC
++ NOUN B-O
+fibroblasts NOUN B-O
+( PUNCT B-O
+Fig NUM B-O
+6C NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+matrix NOUN B-LF
+metalloproteinase NOUN I-LF
+( PUNCT B-O
+MMP PROPN B-AC
+) PUNCT B-O
+family NOUN B-O
+is AUX B-O
+primarily ADV B-O
+responsible ADJ B-O
+for ADP B-O
+the DET B-O
+degradation NOUN B-O
+and CCONJ B-O
+remodeling NOUN B-O
+of ADP B-O
+extracellular ADJ B-O
+matrix NOUN B-O
+[ PUNCT B-O
+6,21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+After ADP B-O
+heat NOUN B-O
+antigen NOUN B-O
+retrieval NOUN B-O
+using VERB B-O
+sodium NOUN B-O
+citrate NOUN B-O
+buffer NOUN B-O
+, PUNCT B-O
+brain NOUN B-O
+sections NOUN B-O
+were AUX B-O
+incubated VERB B-O
+with ADP B-O
+blocking VERB B-O
+buffer NOUN B-O
+( PUNCT B-O
+10 NUM B-O
+% NOUN B-O
+Normal PROPN B-O
+Goat PROPN B-O
+Serum PROPN B-O
+, PUNCT B-O
+1 NUM B-O
+% NOUN B-O
+BSA PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+3 NUM B-O
+M NOUN B-O
+Glycine PROPN B-O
+in ADP B-O
+TBS-0.1 NUM B-O
+% NOUN B-O
+Triton PROPN B-O
+- PUNCT B-O
+X PROPN B-O
+) PUNCT B-O
+for ADP B-O
+1 NUM B-O
+hour NOUN B-O
+at ADP B-O
+room NOUN B-LF
+temperature NOUN I-LF
+( PUNCT B-O
+RT PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+After ADP B-O
+blocking VERB B-O
+, PUNCT B-O
+antibodies NOUN B-O
+were AUX B-O
+diluted VERB B-O
+in ADP B-O
+blocking VERB B-O
+buffer NOUN B-O
+and CCONJ B-O
+incubated VERB B-O
+overnight ADV B-O
+at ADP B-O
+4 NUM B-O
+° NOUN B-O
+C NOUN B-O
+. PUNCT B-O
+
+Healthy ADJ B-LF
+controls NOUN I-LF
+( PUNCT B-O
+HC PROPN B-AC
+): PUNCT B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+59 NUM B-O
+) PUNCT B-O
+21 NUM B-O
+adult NOUN B-O
+healthy ADJ B-LF
+controls NOUN I-LF
+and CCONJ B-O
+38 NUM B-O
+children NOUN B-O
+older ADJ B-O
+than ADP B-O
+4 NUM B-O
+were AUX B-O
+included VERB B-O
+in ADP B-O
+Study NOUN B-O
+2 NUM B-O
+. PUNCT B-O
+
+Primaquine PROPN B-LF
+( PUNCT B-O
+PQ PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+been AUX B-O
+used VERB B-O
+for ADP B-O
+over ADP B-O
+65 NUM B-O
+years NOUN B-O
+and CCONJ B-O
+is AUX B-O
+currently ADV B-O
+the DET B-O
+only ADJ B-O
+widely ADV B-O
+available ADJ B-O
+hypnozoitocidal ADJ B-O
+drug NOUN B-O
+for ADP B-O
+P. PROPN B-O
+vivax PROPN B-O
+and CCONJ B-O
+P. PROPN B-O
+ovale PROPN B-O
+. PUNCT B-O
+
+A DET B-O
+recent ADJ B-O
+report NOUN B-O
+suggests VERB B-O
+that SCONJ B-O
+SDF-1 PROPN B-O
+promotes VERB B-O
+epidermal ADJ B-LF
+stem NOUN I-LF
+cell NOUN I-LF
+( PUNCT B-O
+ESC PROPN B-AC
+) PUNCT B-O
+migration NOUN B-O
+and CCONJ B-O
+accelerates VERB B-O
+wound NOUN B-O
+healing NOUN B-O
+in ADP B-O
+vivo ADV B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Extracted VERB B-O
+peptides NOUN B-O
+were AUX B-O
+analysed VERB B-O
+by ADP B-O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+– PUNCT I-LF
+tandem NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT B-O
+LC–MS/MS PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+the DET B-O
+Orbitrap PROPN B-O
+Fusion PROPN B-O
+mass NOUN B-O
+spectrometer NOUN B-O
+and CCONJ B-O
+nanoflow NOUN B-O
+- PUNCT B-O
+HPLC NOUN B-O
+system NOUN B-O
+U3000 PROPN B-O
+( PUNCT B-O
+Thermo PROPN B-O
+Fisher PROPN B-O
+Scientific PROPN B-O
+, PUNCT B-O
+UK PROPN B-O
+) PUNCT B-O
+[ PUNCT B-O
+48,50 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+aimed VERB B-O
+to PART B-O
+assess VERB B-O
+the DET B-O
+comparability NOUN B-O
+among ADP B-O
+assays NOUN B-O
+using VERB B-O
+freshly ADV B-O
+frozen VERB B-O
+human ADJ B-O
+sera NOUN B-O
+and CCONJ B-O
+external ADJ B-LF
+quality NOUN I-LF
+assessment NOUN I-LF
+( PUNCT B-O
+EQA PROPN B-AC
+) PUNCT B-O
+data NOUN B-O
+in ADP B-O
+China PROPN B-O
+. PUNCT B-O
+
+The DET B-O
+“ PUNCT B-O
+gold NOUN B-O
+standard NOUN B-O
+” PUNCT B-O
+for ADP B-O
+NACT PROPN B-AC
+response NOUN B-O
+was AUX B-O
+the DET B-O
+5 NUM B-O
+- PUNCT B-O
+years NOUN B-O
+relapse NOUN B-LF
+free ADJ I-LF
+survival NOUN I-LF
+( PUNCT B-O
+RFS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+as SCONJ B-O
+it PRON B-O
+provides VERB B-O
+a DET B-O
+reasonable ADJ B-O
+threshold NOUN B-O
+to ADP B-O
+capture VERB B-O
+all DET B-O
+relapses NOUN B-O
+related VERB B-O
+to ADP B-O
+NACT PROPN B-AC
+response NOUN B-O
+[ PUNCT B-O
+11 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+ATP PROPN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+cassette NOUN I-LF
+transporter NOUN I-LF
+A1 NOUN I-LF
+( PUNCT B-O
+ABCA1 PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+cholesterol NOUN B-O
+and CCONJ B-O
+phospholipid NOUN B-O
+transporter NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+mutations NOUN B-O
+in ADP B-O
+ABCA1 PROPN B-AC
+cause VERB B-O
+Tangier PROPN B-LF
+disease NOUN I-LF
+( PUNCT B-O
+TD PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+1–3 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+a DET B-O
+rare ADJ B-O
+disorder NOUN B-O
+characterized VERB B-O
+by ADP B-O
+reduced VERB B-O
+levels NOUN B-O
+of ADP B-O
+plasma NOUN B-O
+high ADJ B-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+( PUNCT B-O
+HDL PROPN B-AC
+) PUNCT B-O
+cholesterol NOUN B-O
+and CCONJ B-O
+increased VERB B-O
+risk NOUN B-O
+for ADP B-O
+coronary ADJ B-O
+artery NOUN B-O
+disease NOUN B-O
+[ PUNCT B-O
+4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+neonatal ADJ B-LF
+mortality NOUN I-LF
+rate NOUN I-LF
+( PUNCT B-O
+NMR PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+declined VERB B-O
+markedly ADV B-O
+in ADP B-O
+recent ADJ B-O
+years NOUN B-O
+in ADP B-O
+Tanzania PROPN B-O
+but CCONJ B-O
+varies VERB B-O
+widely ADV B-O
+across ADP B-O
+the DET B-O
+country NOUN B-O
+. PUNCT B-O
+
+HSV-2 PROPN B-AC
+, PUNCT B-O
+herpes NOUN B-LF
+simplex NOUN I-LF
+virus NOUN I-LF
+type NOUN I-LF
+2 NUM I-LF
+; PUNCT B-O
+STI PROPN B-AC
+, PUNCT B-O
+sexually ADV B-LF
+transmitted VERB I-LF
+infection NOUN I-LF
+. PUNCT B-O
+
+Eight NUM B-O
+databases NOUN B-O
+, PUNCT B-O
+PubMed PROPN B-O
+, PUNCT B-O
+GWAS PROPN B-AC
+, PUNCT B-O
+Embase PROPN B-O
+, PUNCT B-O
+Lochrane PROPN B-O
+, PUNCT B-O
+Ebsco PROPN B-O
+, PUNCT B-O
+CNKI PROPN B-AC
+( PUNCT B-O
+Chinese PROPN B-LF
+National PROPN I-LF
+Knowledge PROPN I-LF
+Infrastructure PROPN I-LF
+) PUNCT B-O
+, PUNCT B-O
+VIP PROPN B-AC
+( PUNCT B-O
+Viper PROPN B-LF
+Database PROPN I-LF
+) PUNCT B-O
+and CCONJ B-O
+ChinaInfo PROPN B-O
+were AUX B-O
+searched VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+a DET B-O
+meta NOUN B-O
+- NOUN B-O
+analysis NOUN B-O
+of ADP B-O
+susceptibility NOUN B-O
+was AUX B-O
+conducted VERB B-O
+between ADP B-O
+SNP45 NOUN B-O
+, PUNCT B-O
+SNP276 NOUN B-O
+polymorphisms NOUN B-O
+and CCONJ B-O
+T2DM PROPN B-AC
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+HWE PROPN B-AC
+test NOUN B-O
+was AUX B-O
+conducted VERB B-O
+to PART B-O
+assess VERB B-O
+the DET B-O
+genetic ADJ B-O
+balance NOUN B-O
+of ADP B-O
+the DET B-O
+study NOUN B-O
+, PUNCT B-O
+evaluate VERB B-O
+the DET B-O
+quality NOUN B-O
+of ADP B-O
+Newcastle PROPN B-LF
+– PUNCT I-LF
+Ottawa PROPN I-LF
+quality NOUN I-LF
+assessment NOUN I-LF
+scale NOUN I-LF
+( PUNCT B-O
+NOS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+establishing VERB B-O
+allelic ADJ B-O
+, PUNCT B-O
+dominant ADJ B-O
+, PUNCT B-O
+recessive ADJ B-O
+, PUNCT B-O
+heterozygous ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+homozygous ADJ B-O
+gene NOUN B-O
+models NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+carbohydrate NOUN B-O
+composition NOUN B-O
+of ADP B-O
+the DET B-O
+extracts NOUN B-O
+was AUX B-O
+analysed VERB B-O
+using VERB B-O
+polysaccharide NOUN B-LF
+analysis NOUN I-LF
+by ADP I-LF
+carbohydrate NOUN I-LF
+gel NOUN I-LF
+electrophoresis NOUN I-LF
+( PUNCT B-O
+PACE PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+high ADJ B-O
+- NOUN B-O
+performance NOUN B-O
+anion NOUN B-O
+- NOUN B-O
+exchange NOUN B-O
+chromatography NOUN B-O
+( PUNCT B-O
+HPAEC PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Whether SCONJ B-O
+there PRON B-O
+were VERB B-O
+any DET B-O
+proteinaceous ADJ B-O
+moieties NOUN B-O
+linked VERB B-O
+to ADP B-O
+β PUNCT B-O
+- NOUN B-O
+glucan NOUN B-O
+was AUX B-O
+also ADV B-O
+examined VERB B-O
+. PUNCT B-O
+
+Wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+( PUNCT B-O
+WT PROPN B-AC
+) PUNCT B-O
+Salmonella NOUN B-O
+was AUX B-O
+electroporated VERB B-O
+with ADP B-O
+6 NUM B-O
+μM PROPN B-O
+I NOUN B-O
+- PUNCT B-O
+switch NOUN B-O
+and CCONJ B-O
+recovered VERB B-O
+in ADP B-O
+SOC PROPN B-O
+for ADP B-O
+1 NUM B-O
+h NOUN B-O
+at ADP B-O
+37 NUM B-O
+° NOUN B-O
+C NOUN B-O
+, PUNCT B-O
+followed VERB B-O
+by ADP B-O
+three NUM B-O
+washes NOUN B-O
+with ADP B-O
+PBS PROPN B-O
+. PUNCT B-O
+
+Bacteria NOUN B-O
+were AUX B-O
+then ADV B-O
+clamped VERB B-O
+at ADP B-O
+various ADJ B-O
+pH NOUN B-O
+values NOUN B-O
+in ADP B-O
+K+-rich NOUN B-O
+buffer NOUN B-O
+containing VERB B-O
+40 NUM B-O
+μM PROPN B-O
+nigericin NOUN B-O
+for ADP B-O
+1 NUM B-O
+h NOUN B-O
+at ADP B-O
+room NOUN B-LF
+temperature NOUN I-LF
+( PUNCT B-O
+RT PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+imaged VERB B-O
+on ADP B-O
+an DET B-O
+Applied PROPN B-O
+Precision PROPN B-O
+Delta PROPN B-O
+Vision PROPN B-O
+inverted VERB B-O
+wide ADJ B-O
+- PUNCT B-O
+field NOUN B-O
+fluorescence NOUN B-O
+microscope NOUN B-O
+. PUNCT B-O
+
+Protein NOUN B-O
+export NOUN B-O
+via ADP B-O
+both DET B-O
+fT3SS PROPN B-AC
+and CCONJ B-O
+vT3SS PROPN B-AC
+is AUX B-O
+primarily ADV B-O
+dependent ADJ B-O
+on ADP B-O
+the DET B-O
+proton NOUN B-LF
+motive NOUN I-LF
+force NOUN I-LF
+( PUNCT B-O
+pmf PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+5–9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+CPM PROPN B-AC
+, PUNCT B-O
+counts NOUN B-LF
+per ADP I-LF
+minute NOUN I-LF
+; PUNCT B-O
+CRF PROPN B-AC
+, PUNCT B-O
+cardiorespiratory ADJ B-LF
+fitness NOUN I-LF
+; PUNCT B-O
+CI PROPN B-O
+, PUNCT B-O
+confidence NOUN B-O
+interval NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+standard ADJ B-O
+test NOUN B-O
+for ADP B-O
+infection NOUN B-O
+is AUX B-O
+the DET B-O
+tuberculin NOUN B-LF
+skin NOUN I-LF
+test NOUN I-LF
+( PUNCT B-O
+TST PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+this PRON B-O
+, PUNCT B-O
+bacterial ADJ B-O
+antigens NOUN B-O
+( PUNCT B-O
+proteins NOUN B-O
+that PRON B-O
+the DET B-O
+immune ADJ B-O
+system NOUN B-O
+recognize VERB B-O
+as ADP B-O
+foreign ADJ B-O
+) PUNCT B-O
+are AUX B-O
+injected VERB B-O
+under ADP B-O
+the DET B-O
+skin NOUN B-O
+. PUNCT B-O
+
+No PROPN B-O
+, PUNCT B-O
+core NOUN B-O
+number NOUN B-O
+; PUNCT B-O
+Dx NOUN B-O
+, PUNCT B-O
+diagnosis NOUN B-O
+; PUNCT B-O
+ILC PROPN B-AC
+, PUNCT B-O
+invasive ADJ B-LF
+lobular ADJ I-LF
+carcinoma NOUN I-LF
+; PUNCT B-O
+ITC PROPN B-AC
+, PUNCT B-O
+invasive ADJ B-LF
+tubular ADJ I-LF
+carcinoma NOUN I-LF
+; PUNCT B-O
++ NUM B-O
+, PUNCT B-O
+positive ADJ B-O
+; PUNCT B-O
+EXP PROPN B-AC
+, PUNCT B-O
+expression NOUN B-LF
+; PUNCT B-O
+INTPN PROPN B-AC
+, PUNCT B-O
+interpretation NOUN B-LF
+after ADP B-O
+considering VERB B-O
+the DET B-O
+1 NUM B-O
++ NUM B-O
+intensity NOUN B-O
+( PUNCT B-O
+2a NUM B-O
+) PUNCT B-O
+as ADP B-O
+negative ADJ B-O
+; PUNCT B-O
+LC PROPN B-AC
+, PUNCT B-O
+lymphocyte NOUN B-LF
+; PUNCT B-O
+NS PROPN B-AC
+, PUNCT B-O
+no DET B-LF
+lymphocytes NOUN B-LF
+seen VERB I-LF
+Ab PROPN B-AC
+, PUNCT B-O
+antibody NOUN B-LF
+; PUNCT B-O
+Iso PROPN B-O
+, PUNCT B-O
+Isotype PROPN B-O
+control NOUN B-O
+. PUNCT B-O
+
+STAT3 PROPN B-AC
+decoy NOUN B-O
+was AUX B-O
+loaded VERB B-O
+on ADP B-O
+cationic ADJ B-O
+lipid NOUN B-O
+microbubbles NOUN B-LF
+( PUNCT B-O
+STAT3 PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+loaded VERB B-O
+on ADP B-O
+liposome NOUN B-O
+- PUNCT B-O
+conjugated VERB B-O
+lipid NOUN B-O
+microbubbles NOUN B-LF
+to PART B-O
+form VERB B-O
+-MBSTAT3 PROPN B-AC
+- PUNCT B-O
+loaded VERB B-O
+liposome NOUN B-O
+- PUNCT B-O
+microbubble NOUN B-LF
+complexes NOUN B-O
+( PUNCT B-O
+STAT3 PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+-LPXUTMC PROPN B-AC
+treatment NOUN B-O
+efficacy NOUN B-O
+with ADP B-O
+these DET B-O
+two NUM B-O
+formulations NOUN B-O
+was AUX B-O
+evaluated VERB B-O
+in ADP B-O
+vitro ADV B-O
+using VERB B-O
+viability NOUN B-O
+and CCONJ B-O
+apoptosis NOUN B-O
+assays NOUN B-O
+in ADP B-O
+CAL33 PROPN B-O
+( PUNCT B-O
+human ADJ B-O
+HNSCC PROPN B-AC
+) PUNCT B-O
+cells NOUN B-O
+. PUNCT B-O
+
+BF PROPN B-O
+, PUNCT B-O
+Burkina PROPN B-O
+Faso PROPN B-O
+; PUNCT B-O
+DRC PROPN B-AC
+, PUNCT B-O
+Democratic PROPN B-LF
+Republic PROPN I-LF
+of ADP I-LF
+the DET I-LF
+Congo PROPN I-LF
+; PUNCT B-O
+EMEP PROPN B-O
+, PUNCT B-O
+Evaluation NOUN B-O
+of ADP B-O
+Medications NOUN B-O
+used VERB B-O
+in ADP B-O
+Early PROPN B-O
+Pregnancy NOUN B-O
+; PUNCT B-O
+GA PROPN B-O
+, PUNCT B-O
+gestational ADJ B-O
+age NOUN B-O
+; PUNCT B-O
+IPTp PROPN B-AC
+, PUNCT B-O
+intermittent ADJ B-LF
+preventive ADJ I-LF
+treatment NOUN I-LF
+in ADP I-LF
+pregnancy NOUN I-LF
+; PUNCT B-O
+ITN PROPN B-O
+, PUNCT B-O
+insecticide NOUN B-O
+- PUNCT B-O
+treated VERB B-O
+bed NOUN B-O
+nets NOUN B-O
+; PUNCT B-O
+M3 PROPN B-AC
+, PUNCT B-O
+Maternal PROPN B-LF
+Malaria NOUN I-LF
+and CCONJ I-LF
+Malnutrition PROPN I-LF
+; PUNCT B-O
+PNG PROPN B-AC
+, PUNCT B-O
+Papua PROPN B-LF
+New PROPN I-LF
+Guinea PROPN I-LF
+; PUNCT B-O
+STOPPAM PROPN B-O
+, PUNCT B-O
+Strategies NOUN B-O
+to PART B-O
+Prevent VERB B-O
+Pregnancy NOUN B-O
+- PUNCT B-O
+Associated VERB B-O
+Malaria NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+prognostic ADJ B-O
+values NOUN B-O
+of ADP B-O
+left ADJ B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+( PUNCT B-O
+LVEF PROPN B-AC
+) PUNCT B-O
+during ADP B-O
+heart NOUN B-LF
+failure NOUN I-LF
+( PUNCT B-O
+HF PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+acute ADJ B-O
+decompensation NOUN B-O
+or CCONJ B-O
+after ADP B-O
+optimal ADJ B-O
+treatment NOUN B-O
+have AUX B-O
+not PART B-O
+been AUX B-O
+extensively ADV B-O
+studied VERB B-O
+. PUNCT B-O
+
+( PUNCT B-O
+Photo- ADJ B-O
+) PUNCT B-O
+chemical ADJ B-O
+cross ADJ B-O
+- ADJ B-O
+linking ADJ B-O
+combined VERB B-O
+with ADP B-O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+( PUNCT B-O
+MS PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+evolved VERB B-O
+as ADP B-O
+an DET B-O
+alternative ADJ B-O
+method NOUN B-O
+to PART B-O
+obtain VERB B-O
+low ADJ B-O
+- ADJ B-O
+resolution NOUN B-O
+three NUM B-O
+- ADJ B-O
+dimensional ADJ B-O
+( PUNCT B-O
+3D ADJ B-O
+) PUNCT B-O
+structural ADJ B-O
+information NOUN B-O
+of ADP B-O
+proteins NOUN B-O
+and CCONJ B-O
+protein NOUN B-O
+complexes.[1–9 NUM B-O
+] PUNCT B-O
+The DET B-O
+cross ADJ B-O
+- ADJ B-O
+linking ADJ B-O
+/ SYM B-O
+MS PROPN B-AC
+approach NOUN B-O
+allows VERB B-O
+deriving VERB B-O
+structural ADJ B-O
+information NOUN B-O
+by ADP B-O
+covalently ADV B-O
+connecting VERB B-O
+pairs NOUN B-O
+of ADP B-O
+functional ADJ B-O
+groups NOUN B-O
+in ADP B-O
+the DET B-O
+protein(s NOUN B-O
+) PUNCT B-O
+under ADP B-O
+investigation NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+widespread ADJ B-O
+presence NOUN B-O
+of ADP B-O
+overweight NOUN B-O
+and CCONJ B-O
+obesity NOUN B-O
+increases VERB B-O
+with ADP B-O
+every DET B-O
+decade NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+number NOUN B-O
+of ADP B-O
+people NOUN B-O
+with ADP B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+> ADP B-O
+30 NUM B-O
+kg NOUN B-O
+/ SYM B-O
+m2 NOUN B-O
+has AUX B-O
+doubled VERB B-O
+in ADP B-O
+the DET B-O
+last ADJ B-O
+30 NUM B-O
+years NOUN B-O
+. PUNCT B-O
+
+Effect NOUN B-O
+of ADP B-O
+mitoCCCP PROPN B-AC
+and CCONJ B-O
+CCCP PROPN B-AC
+on ADP B-O
+the DET B-O
+pH NOUN B-O
+gradient NOUN B-O
+across ADP B-O
+the DET B-O
+membranes NOUN B-O
+of ADP B-O
+submitochondrial ADJ B-LF
+particles NOUN I-LF
+( PUNCT B-O
+SMP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+as SCONJ B-O
+measured VERB B-O
+by ADP B-O
+ACMA PROPN B-AC
+( PUNCT B-O
+0.5 NUM B-O
+μg NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+) PUNCT B-O
+fluorescence NOUN B-O
+. PUNCT B-O
+
+Within ADP B-O
+the DET B-O
+DOT PROPN B-AC
+- PUNCT B-O
+group NOUN B-O
+, PUNCT B-O
+SVR12 PROPN B-O
+was AUX B-O
+achieved VERB B-O
+in ADP B-O
+99.1 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+: PUNCT B-O
+95.0–100 NUM B-O
+; PUNCT B-O
+n NOUN B-O
+= SYM B-O
+109/110 NUM B-O
+) PUNCT B-O
+with ADP B-O
+one NUM B-O
+patient NOUN B-O
+experiencing VERB B-O
+treatment NOUN B-O
+failure NOUN B-O
+, PUNCT B-O
+while SCONJ B-O
+n NOUN B-O
+= SYM B-O
+12/122 NUM B-O
+( PUNCT B-O
+9.8 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+patients NOUN B-O
+were AUX B-O
+excluded VERB B-O
+due ADP B-O
+to ADP B-O
+loss NOUN B-O
+of ADP B-O
+follow NOUN B-LF
+- PUNCT I-LF
+up NOUN I-LF
+( PUNCT B-O
+FU PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+5 NUM B-O
+patients NOUN B-O
+showed VERB B-O
+HCV PROPN B-AC
+reinfection NOUN B-O
+after ADP B-O
+achieving VERB B-O
+SVR12 PROPN B-O
+. PUNCT B-O
+
+We PRON B-O
+assumed VERB B-O
+that PRON B-O
+lung NOUN B-O
+tissues NOUN B-O
+are AUX B-O
+protected VERB B-O
+from ADP B-O
+overactive ADJ B-O
+immune ADJ B-O
+cells NOUN B-O
+by ADP B-O
+the DET B-O
+same ADJ B-O
+hypoxia NOUN B-O
+- PUNCT B-O
+driven VERB B-O
+mechanism NOUN B-O
+and CCONJ B-O
+immunosuppressive ADJ B-O
+adenosine NOUN B-LF
+A2A NOUN I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+A2AR)-mediated PROPN B-AC
+mechanism NOUN B-O
+that PRON B-O
+was AUX B-O
+recently ADV B-O
+shown VERB B-O
+to PART B-O
+play VERB B-O
+a DET B-O
+critical ADJ B-O
+role NOUN B-O
+in ADP B-O
+the DET B-O
+down NOUN B-O
+- PUNCT B-O
+regulation NOUN B-O
+of ADP B-O
+inflammation NOUN B-O
+and CCONJ B-O
+tissue NOUN B-O
+damage NOUN B-O
+in ADP B-O
+different ADJ B-O
+models NOUN B-O
+[ PUNCT B-O
+4–7 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+( PUNCT B-O
+FDR PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+controlled VERB B-O
+by ADP B-O
+adjusting VERB B-O
+the DET B-O
+p NOUN B-O
+value NOUN B-O
+using VERB B-O
+the DET B-O
+Benjamini PROPN B-O
+- PUNCT B-O
+Hochberg PROPN B-O
+algorithm NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+used VERB B-O
+the DET B-O
+three NUM B-O
+Ethiopian ADJ B-LF
+demographic ADJ I-LF
+and CCONJ I-LF
+health NOUN I-LF
+surveys NOUN I-LF
+( PUNCT B-O
+EDHSs PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+2005 NUM B-O
+, PUNCT B-O
+2011 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+2016 NUM B-O
+) PUNCT B-O
+data NOUN B-O
+, PUNCT B-O
+which PRON B-O
+are AUX B-O
+the DET B-O
+nationally ADV B-O
+representative ADJ B-O
+surveys NOUN B-O
+performed VERB B-O
+in ADP B-O
+Ethiopia PROPN B-O
+. PUNCT B-O
+
+Acquiring VERB B-O
+and CCONJ B-O
+sharing VERB B-O
+large ADJ B-O
+amounts NOUN B-O
+of ADP B-O
+neuroimaging NOUN B-O
+data NOUN B-O
+have AUX B-O
+recently ADV B-O
+become VERB B-O
+critical ADJ B-O
+for ADP B-O
+bridging VERB B-O
+the DET B-O
+gap NOUN B-O
+between ADP B-O
+basic ADJ B-O
+neuroscience NOUN B-O
+research NOUN B-O
+and CCONJ B-O
+clinical ADJ B-O
+applications NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+the DET B-O
+diagnosis NOUN B-O
+and CCONJ B-O
+treatment NOUN B-O
+of ADP B-O
+psychiatric ADJ B-O
+disorders NOUN B-O
+( PUNCT B-O
+Human PROPN B-LF
+Connectome PROPN I-LF
+Project PROPN I-LF
+[ PUNCT B-O
+HCP PROPN B-AC
+] PUNCT B-O
+[ PUNCT B-O
+1 X B-O
+] PUNCT B-O
+[ PUNCT B-O
+http://www.humanconnectomeproject.org/ X B-O
+] PUNCT B-O
+; PUNCT B-O
+Human PROPN B-O
+Brain PROPN B-O
+Project PROPN B-O
+[ PUNCT B-O
+https://www.humanbrainproject.eu/en/ X B-O
+] PUNCT B-O
+; PUNCT B-O
+UK PROPN B-O
+Biobank PROPN B-O
+[ PUNCT B-O
+http://www.ukbiobank.ac.uk/ X B-O
+] PUNCT B-O
+; PUNCT B-O
+and CCONJ B-O
+Strategic PROPN B-LF
+Research PROPN I-LF
+Program PROPN I-LF
+for ADP I-LF
+Brain PROPN I-LF
+Sciences PROPN I-LF
+[ PUNCT B-O
+SRPBS PROPN B-AC
+] PUNCT B-O
+[ PUNCT B-O
+2 X B-O
+] PUNCT B-O
+[ PUNCT B-O
+https://bicr.atr.jp/decnefpro/ X B-O
+] PUNCT B-O
+) PUNCT B-O
+[ PUNCT B-O
+3–5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Analysis NOUN B-O
+of ADP B-O
+the DET B-O
+molecular ADJ B-LF
+dynamics NOUN I-LF
+( PUNCT B-O
+MD PROPN B-AC
+) PUNCT B-O
+trajectories NOUN B-O
+and CCONJ B-O
+binding VERB B-O
+free ADJ B-O
+energy NOUN B-O
+components NOUN B-O
+shed VERB B-O
+light NOUN B-O
+into ADP B-O
+understanding VERB B-O
+the DET B-O
+mechanism NOUN B-O
+of ADP B-O
+the DET B-O
+binding VERB B-O
+specificity NOUN B-O
+of ADP B-O
+the DET B-O
+Abl PROPN B-O
+SH3 PROPN B-AC
+domain NOUN B-O
+. PUNCT B-O
+
+HCVcc PROPN B-AC
+was AUX B-O
+produced VERB B-O
+and CCONJ B-O
+50 NUM B-LF
+% NOUN I-LF
+tissue NOUN I-LF
+culture NOUN I-LF
+infective ADJ I-LF
+dose NOUN I-LF
+( PUNCT B-O
+TCID50 PROPN B-AC
+) PUNCT B-O
+determined VERB B-O
+as SCONJ B-O
+described VERB B-O
+[ PUNCT B-O
+37 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+are AUX B-O
+presented VERB B-O
+with ADP B-O
+counts NOUN B-O
+unless SCONJ B-O
+otherwise ADV B-O
+stated VERB B-O
+. PUNCT B-O
+
+95%CI PROPN B-AC
+: PUNCT B-O
+95 NUM B-LF
+% NOUN I-LF
+confidence NOUN I-LF
+interval NOUN I-LF
+; PUNCT B-O
+BSI PROPN B-AC
+: PUNCT B-O
+Bronchiectasis PROPN B-LF
+Severity PROPN I-LF
+Index PROPN I-LF
+. PUNCT B-O
+
+To PART B-O
+separate VERB B-O
+the DET B-O
+active ADJ B-O
+compounds NOUN B-O
+, PUNCT B-O
+preparative ADJ B-LF
+high ADJ I-LF
+performance NOUN I-LF
+liquid NOUN I-LF
+chromatography NOUN I-LF
+( PUNCT B-O
+PHPLC PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+conducted VERB B-O
+on ADP B-O
+a DET B-O
+Waters PROPN B-O
+2545 NUM B-O
+series NOUN B-O
+instrument NOUN B-O
+( PUNCT B-O
+Waters PROPN B-O
+, PUNCT B-O
+USA PROPN B-O
+) PUNCT B-O
+equipped VERB B-O
+with ADP B-O
+a DET B-O
+OBD PROPN B-O
+- PUNCT B-O
+C18 NUM B-O
+column NOUN B-O
+( PUNCT B-O
+19 NUM B-O
+mm NOUN B-O
+×150 NUM B-O
+mm NOUN B-O
+, PUNCT B-O
+10 NUM B-O
+μm NOUN B-O
+, PUNCT B-O
+Waters PROPN B-O
+, PUNCT B-O
+USA PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+mobile ADJ B-O
+phase NOUN B-O
+used VERB B-O
+for ADP B-O
+PHPLC PROPN B-AC
+was AUX B-O
+methanol NOUN B-O
+/ SYM B-O
+H2O NOUN B-O
+( PUNCT B-O
+1:4 NOUN B-O
+, PUNCT B-O
+v NOUN B-O
+/ SYM B-O
+v NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+applied VERB B-O
+with ADP B-O
+a DET B-O
+flow NOUN B-O
+rate NOUN B-O
+of ADP B-O
+8 NUM B-O
+mL NOUN B-O
+/ SYM B-O
+min NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+ultraviolet ADJ B-O
+detection NOUN B-O
+was AUX B-O
+a DET B-O
+210 NUM B-O
+nm NOUN B-O
+. PUNCT B-O
+
+Enhanced VERB B-O
+mean ADJ B-O
+intensity NOUN B-O
+images NOUN B-O
+are AUX B-O
+shown VERB B-O
+to ADP B-O
+demonstrate VERB B-O
+the DET B-O
+alignment NOUN B-O
+procedure NOUN B-O
+between ADP B-O
+a DET B-O
+recording NOUN B-O
+in ADP B-O
+Iso PROPN B-AC
+( PUNCT B-O
+A NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+one NUM B-O
+during ADP B-O
+wakefulness NOUN B-O
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+C NOUN B-O
+) PUNCT B-O
+Mean ADJ B-O
+intensity NOUN B-O
+image NOUN B-O
+of ADP B-O
+the DET B-O
+awake ADJ B-O
+recording NOUN B-O
+aligned VERB B-O
+to ADP B-O
+the DET B-O
+anesthesia NOUN B-O
+condition NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D NOUN B-O
+) PUNCT B-O
+Overlaid VERB B-O
+, PUNCT B-O
+enhanced VERB B-O
+mean ADJ B-O
+intensity NOUN B-O
+images NOUN B-O
+before ADP B-O
+and CCONJ B-O
+after SCONJ B-O
+( PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+the DET B-O
+alignment NOUN B-O
+algorithm NOUN B-O
+was AUX B-O
+applied VERB B-O
+. PUNCT B-O
+
+( PUNCT B-O
+F NOUN B-O
+) PUNCT B-O
+ROIs PROPN B-AC
+of ADP B-O
+active ADJ B-O
+neurons NOUN B-O
+during ADP B-O
+wakefulness NOUN B-O
+( PUNCT B-O
+pink NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+Iso PROPN B-AC
+anesthesia NOUN B-O
+( PUNCT B-O
+cyan NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+their PRON B-O
+overlap NOUN B-O
+( PUNCT B-O
+black NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+G NOUN B-O
+– PUNCT B-O
+I NOUN B-O
+) PUNCT B-O
+Magnified VERB B-O
+views NOUN B-O
+of ADP B-O
+a DET B-O
+randomly ADV B-O
+selected VERB B-O
+sections NOUN B-O
+from ADP B-O
+panels NOUN B-O
+( PUNCT B-O
+D)–(F NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Iso PROPN B-AC
+, PUNCT B-O
+isoflurane NOUN B-LF
+; PUNCT B-O
+ROI PROPN B-AC
+, PUNCT B-O
+region NOUN B-LF
+of ADP I-LF
+interest NOUN I-LF
+. PUNCT B-O
+
+For ADP B-O
+example NOUN B-O
+, PUNCT B-O
+the DET B-O
+depletion NOUN B-O
+of ADP B-O
+CpG NOUN B-O
+dinucleotides NOUN B-O
+in ADP B-O
+vertebrate NOUN B-O
+- PUNCT B-O
+infecting VERB B-O
+RNA NOUN B-O
+virus NOUN B-O
+genomes NOUN B-O
+may AUX B-O
+have AUX B-O
+arisen VERB B-O
+to PART B-O
+evade VERB B-O
+zinc NOUN B-LF
+- PUNCT I-LF
+finger NOUN I-LF
+antiviral ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+ZAP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+an DET B-O
+interferon NOUN B-LF
+- PUNCT I-LF
+stimulated VERB I-LF
+gene NOUN I-LF
+( PUNCT B-O
+ISG PROPN B-AC
+) PUNCT B-O
+that PRON B-O
+initiates VERB B-O
+the DET B-O
+degradation NOUN B-O
+of ADP B-O
+CpG NOUN B-O
+- PUNCT B-O
+rich ADJ B-O
+RNA NOUN B-O
+molecules NOUN B-O
+[ PUNCT B-O
+12 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+All DET B-O
+participants NOUN B-O
+in ADP B-O
+the DET B-O
+training NOUN B-O
+program NOUN B-O
+were AUX B-O
+key ADJ B-O
+persons NOUN B-O
+, PUNCT B-O
+recruited VERB B-O
+among ADP B-O
+93 NUM B-O
+eligible ADJ B-O
+baggage NOUN B-O
+handlers NOUN B-O
+identified VERB B-O
+to ADP B-O
+have VERB B-O
+key ADJ B-O
+roles NOUN B-O
+in ADP B-O
+the DET B-O
+company NOUN B-O
+( PUNCT B-O
+Table NOUN B-O
+1 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+i.e. X B-O
+safety NOUN B-LF
+officers NOUN I-LF
+( PUNCT B-O
+SO PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+16 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+instructors NOUN B-O
+teaching VERB B-O
+the DET B-O
+use NOUN B-O
+of ADP B-O
+technical ADJ B-O
+devices NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+26 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+coordinators NOUN B-O
+allocating VERB B-O
+tasks NOUN B-O
+to ADP B-O
+baggage NOUN B-O
+handlers NOUN B-O
+during ADP B-O
+the DET B-O
+shift NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+42 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+managers NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+9 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+ChIP PROPN B-O
+, PUNCT B-O
+chromatin NOUN B-O
+immunoprecipitation NOUN B-O
+; PUNCT B-O
+CREB PROPN B-AC
+, PUNCT B-O
+cAMP NOUN B-LF
+responsive ADJ I-LF
+element NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+; PUNCT B-O
+DHS PROPN B-AC
+, PUNCT B-O
+DNase NOUN B-LF
+hypersensitive ADJ I-LF
+site NOUN I-LF
+; PUNCT B-O
+FDR PROPN B-AC
+, PUNCT B-O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+; PUNCT B-O
+FOXO1 PROPN B-AC
+, PUNCT B-O
+Forkhead PROPN B-LF
+box NOUN I-LF
+O1 NOUN I-LF
+; PUNCT B-O
+GR PROPN B-AC
+, PUNCT B-O
+glucocorticoid NOUN B-LF
+receptor NOUN I-LF
+; PUNCT B-O
+H3K27Ac PROPN B-O
+, PUNCT B-O
+Histone NOUN B-O
+3 NUM B-O
+lysine NOUN B-O
+27 NUM B-O
+acetylation NOUN B-O
+; PUNCT B-O
+ROC PROPN B-AC
+, PUNCT B-O
+receiver NOUN B-LF
+operating NOUN I-LF
+characteristic NOUN I-LF
+; PUNCT B-O
+TSS PROPN B-AC
+, PUNCT B-O
+transcription NOUN B-LF
+start NOUN I-LF
+site NOUN I-LF
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+Mexican ADJ B-O
+cohort NOUN B-O
+, PUNCT B-O
+the DET B-O
+fibrotic ADJ B-O
+non ADJ B-O
+- NOUN B-O
+IPF PROPN B-AC
+group NOUN B-O
+consisted VERB B-O
+of ADP B-O
+patients NOUN B-O
+with ADP B-O
+Rheumatoid PROPN B-LF
+Arthritis PROPN I-LF
+interstitial ADJ B-LF
+lung NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+RA PROPN B-AC
+-ILD PROPN B-AC
+n NOUN B-O
+= SYM B-O
+18 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+Sjögren PROPN B-O
+Syndrome PROPN B-O
+interstitial ADJ B-LF
+lung NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+SS NOUN B-O
+- NOUN B-O
+ILD PROPN B-AC
+n NOUN B-O
+= SYM B-O
+5 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+chronic ADJ B-LF
+hypersensitivity ADJ I-LF
+pneumonitis NOUN I-LF
+( PUNCT B-O
+cHP PROPN B-AC
+n NOUN B-O
+= SYM B-O
+46 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+BChl PROPN B-AC
+, PUNCT B-O
+bacteriochlorophyll NOUN B-LF
+; PUNCT B-O
+CD PROPN B-AC
+, PUNCT B-O
+circular ADJ B-LF
+dichroism NOUN I-LF
+; PUNCT B-O
+LD PROPN B-AC
+, PUNCT B-O
+linear ADJ B-LF
+dichroism NOUN I-LF
+; PUNCT B-O
+LH1 PROPN B-AC
+, PUNCT B-O
+light NOUN B-LF
+- PUNCT I-LF
+harvesting NOUN I-LF
+complex NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+mdeg NOUN B-O
+, PUNCT B-O
+millidegree NOUN B-O
+; PUNCT B-O
+NIR PROPN B-AC
+, PUNCT B-O
+near ADJ B-LF
+infrared ADJ I-LF
+region NOUN I-LF
+; PUNCT B-O
+rel NOUN B-O
+. PUNCT B-O
+
+u. PROPN B-O
+, PUNCT B-O
+relative ADJ B-O
+units NOUN B-O
+. PUNCT B-O
+
+MPoRT PROPN B-AC
+parameters NOUN B-O
+, PUNCT B-O
+including VERB B-O
+variable ADJ B-O
+description NOUN B-O
+, PUNCT B-O
+derivation NOUN B-O
+and CCONJ B-O
+calibration NOUN B-O
+are AUX B-O
+available ADJ B-O
+as ADP B-O
+Predictive PROPN B-LF
+Modelling PROPN I-LF
+Markup PROPN I-LF
+Language NOUN I-LF
+( PUNCT B-O
+PMML PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Lime PROPN B-O
+questionnaire NOUN B-O
+files NOUN B-O
+( PUNCT B-O
+See VERB B-O
+: PUNCT B-O
+S2 PROPN B-O
+Text PROPN B-O
+, PUNCT B-O
+S3 PROPN B-O
+Text PROPN B-O
+, PUNCT B-O
+https://github.com/Ottawa-mHealth/predictive-algorithms X B-O
+) PUNCT B-O
+[ PUNCT B-O
+41,42 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+components NOUN B-O
+related VERB B-O
+to ADP B-O
+blood NOUN B-LF
+pressure NOUN I-LF
+and CCONJ B-O
+the DET B-O
+metabolism NOUN B-O
+of ADP B-O
+glucose NOUN B-O
+— PUNCT B-O
+high ADJ B-O
+- PUNCT B-O
+normal ADJ B-O
+BP PROPN B-AC
+, PUNCT B-O
+DM2 PROPN B-AC
+, PUNCT B-O
+hypertension NOUN B-O
+and CCONJ B-O
+impaired ADJ B-O
+fasting VERB B-O
+glucose NOUN B-O
+— PUNCT B-O
+were AUX B-O
+, PUNCT B-O
+in ADP B-O
+this DET B-O
+order NOUN B-O
+, PUNCT B-O
+those PRON B-O
+that PRON B-O
+, PUNCT B-O
+when SCONJ B-O
+they PRON B-O
+appear VERB B-O
+first ADV B-O
+, PUNCT B-O
+determine VERB B-O
+having VERB B-O
+a DET B-O
+first ADV B-O
+episode NOUN B-O
+of ADP B-O
+MS PROPN B-AC
+, PUNCT B-O
+whereas SCONJ B-O
+the DET B-O
+components NOUN B-O
+related VERB B-O
+to ADP B-O
+dyslipidaemia NOUN B-O
+were AUX B-O
+associated VERB B-O
+with ADP B-O
+a DET B-O
+lower ADJ B-O
+risk NOUN B-O
+when SCONJ B-O
+they PRON B-O
+appear VERB B-O
+first ADV B-O
+. PUNCT B-O
+
+SIS PROPN B-AC
+- PUNCT B-O
+ECM PROPN B-AC
+; PUNCT B-O
+Small ADJ B-LF
+intestinal ADJ I-LF
+submucosa NOUN I-LF
+- PUNCT B-O
+extra ADJ B-LF
+cellular ADJ I-LF
+matrix NOUN I-LF
+, PUNCT B-O
+TE PROPN B-AC
+; PUNCT B-O
+Tissue NOUN B-LF
+engineering NOUN I-LF
+. PUNCT B-O
+
+Among ADP B-O
+women NOUN B-O
+, PUNCT B-O
+food NOUN B-O
+insufficiency NOUN B-O
+was AUX B-O
+associated VERB B-O
+with ADP B-O
+approximately ADV B-O
+70 NUM B-O
+% NOUN B-O
+higher ADJ B-O
+odds NOUN B-O
+of ADP B-O
+inconsistent ADJ B-O
+condom NOUN B-O
+use NOUN B-O
+with ADP B-O
+a DET B-O
+nonprimary ADJ B-O
+partner NOUN B-O
+after ADP B-O
+adjusting VERB B-O
+for ADP B-O
+other ADJ B-O
+covariates NOUN B-O
+in ADP B-O
+a DET B-O
+multivariate ADJ B-O
+model NOUN B-O
+( PUNCT B-O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+[ X B-O
+AOR PROPN B-AC
+] X B-O
+1.73 NUM B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X B-O
+CI PROPN B-AC
+] X B-O
+1.27–2.36 NUM B-O
+) PUNCT B-O
+( PUNCT B-O
+Table PROPN B-O
+2 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+ASA PROPN B-AC
+, PUNCT B-O
+American PROPN B-LF
+Society PROPN I-LF
+of ADP I-LF
+Anaesthesiologists PROPN I-LF
+; PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+OKS PROPN B-AC
+, PUNCT B-O
+Oxford PROPN B-LF
+Knee PROPN I-LF
+Score PROPN I-LF
+; PUNCT B-O
+TKR PROPN B-AC
+, PUNCT B-O
+total ADJ B-LF
+knee NOUN I-LF
+replacement NOUN I-LF
+. PUNCT B-O
+
+Manuscript NOUN B-O
+, PUNCT B-O
+page NOUN B-O
+5 NUM B-O
+, PUNCT B-O
+line NOUN B-O
+70 NUM B-O
+- PUNCT B-O
+76 NUM B-O
+: PUNCT B-O
+In ADP B-O
+our PRON B-O
+previous ADJ B-O
+work NOUN B-O
+, PUNCT B-O
+we PRON B-O
+integrated VERB B-O
+EBV NOUN B-LF
+- PUNCT I-LF
+EBV PROPN B-AC
+encoded VERB I-LF
+small ADJ I-LF
+RNA NOUN I-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+( PUNCT B-O
+EBER PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+immunohistochemistry NOUN B-O
+of ADP B-O
+DNA NOUN B-O
+mismatch NOUN B-O
+proteins NOUN B-O
+( PUNCT B-O
+-ISHMMR PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Lauren NOUN B-O
+histotyping NOUN B-O
+to ADP B-O
+design VERB B-O
+a DET B-O
+practical ADJ B-O
+-IHCGC PROPN B-AC
+subtyping NOUN B-O
+algorithm NOUN B-O
+, PUNCT B-O
+parallel ADJ B-O
+to ADP B-O
+the DET B-O
+TCGA PROPN B-AC
+classification NOUN B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+2002–2016 NUM B-O
+Nationwide PROPN B-LF
+Inpatient PROPN I-LF
+Sample PROPN I-LF
+( PUNCT B-O
+NIS PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+analyzed VERB B-O
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+we PRON B-O
+have AUX B-O
+performed VERB B-O
+flat ADJ B-O
+panel NOUN B-O
+- PUNCT B-O
+based VERB B-O
+volume NOUN B-O
+computed VERB B-O
+tomography NOUN B-O
+( PUNCT B-O
+fpVCT PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+rapid ADJ B-O
+high ADJ B-O
+- PUNCT B-O
+resolution NOUN B-O
+imaging NOUN B-O
+of ADP B-O
+bone NOUN B-O
+structures NOUN B-O
+in ADP B-O
+combination NOUN B-O
+with ADP B-O
+artificial ADJ B-LF
+neuronal ADJ I-LF
+networks NOUN I-LF
+( PUNCT B-O
+ANNs PROPN B-AC
+) PUNCT B-O
+that PRON B-O
+are AUX B-O
+complex ADJ B-O
+nonlinear ADJ B-O
+computational ADJ B-O
+models NOUN B-O
+, PUNCT B-O
+designed VERB B-O
+much ADV B-O
+like ADP B-O
+the DET B-O
+neuronal ADJ B-O
+organization NOUN B-O
+of ADP B-O
+a DET B-O
+brain NOUN B-O
+[ X B-O
+10–15 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Physical ADJ B-O
+exercise NOUN B-O
+has VERB B-O
+a DET B-O
+neuromodulatory ADJ B-O
+effect NOUN B-O
+on ADP B-O
+the DET B-O
+central ADJ B-LF
+nervous ADJ I-LF
+system NOUN I-LF
+( PUNCT B-O
+CNS PROPN B-AC
+) PUNCT B-O
+partially ADV B-O
+by ADP B-O
+modifying VERB B-O
+expression NOUN B-O
+of ADP B-O
+neuropeptides NOUN B-O
+produced VERB B-O
+and CCONJ B-O
+secreted VERB B-O
+by ADP B-O
+neurons NOUN B-O
+and CCONJ B-O
+glial ADJ B-O
+cells NOUN B-O
+, PUNCT B-O
+among ADP B-O
+which PRON B-O
+the DET B-O
+best ADV B-O
+examined VERB B-O
+are AUX B-O
+brain NOUN B-LF
+- PUNCT I-LF
+derived VERB I-LF
+neurotrophic ADJ I-LF
+factor NOUN I-LF
+( PUNCT B-O
+BDNF PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+glial ADJ B-LF
+cell NOUN I-LF
+line NOUN I-LF
+- PUNCT I-LF
+derived VERB I-LF
+neurotrophic ADJ I-LF
+factor NOUN I-LF
+( PUNCT B-O
+GDNF PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Because SCONJ B-O
+both DET B-O
+neurotrophins NOUN B-O
+can AUX B-O
+cross VERB B-O
+the DET B-O
+brain NOUN B-O
+- PUNCT B-O
+blood NOUN B-O
+barrier NOUN B-O
+( PUNCT B-O
+BBB PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+their PRON B-O
+blood NOUN B-O
+levels NOUN B-O
+indirectly ADV B-O
+reflect VERB B-O
+their PRON B-O
+production NOUN B-O
+in ADP B-O
+the DET B-O
+CNS PROPN B-AC
+. PUNCT B-O
+
+Moreover ADV B-O
+, PUNCT B-O
+both DET B-O
+neuropeptides NOUN B-O
+are AUX B-O
+involved VERB B-O
+in ADP B-O
+modulation NOUN B-O
+of ADP B-O
+dopaminergic ADJ B-O
+and CCONJ B-O
+serotoninergic ADJ B-O
+system NOUN B-O
+function NOUN B-O
+. PUNCT B-O
+
+Trypsin NOUN B-O
+- PUNCT B-O
+EDTA PROPN B-O
+( PUNCT B-O
+0.05 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+was AUX B-O
+prepared VERB B-O
+by ADP B-O
+diluting VERB B-O
+trypsin NOUN B-O
+- PUNCT B-O
+EDTA PROPN B-O
+( PUNCT B-O
+0.5 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+in ADP B-O
+phosphate NOUN B-LF
+- PUNCT I-LF
+buffered VERB I-LF
+saline NOUN I-LF
+( PUNCT B-O
+PBS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+All DET B-O
+cell NOUN B-O
+culture NOUN B-O
+materials NOUN B-O
+were AUX B-O
+obtained VERB B-O
+from ADP B-O
+Gibco PROPN B-O
+( PUNCT B-O
+Life PROPN B-O
+Technologies PROPN B-O
+, PUNCT B-O
+Breda PROPN B-O
+, PUNCT B-O
+The DET B-O
+Netherlands PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Despite SCONJ B-O
+the DET B-O
+significance NOUN B-O
+of ADP B-O
+insertions NOUN B-LF
+and CCONJ I-LF
+deletions NOUN I-LF
+( PUNCT B-O
+indels PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+human ADJ B-O
+genetic ADJ B-O
+disease NOUN B-O
+[ PUNCT B-O
+1 X B-O
+] PUNCT B-O
+and CCONJ B-O
+genome NOUN B-O
+evolution NOUN B-O
+[ PUNCT B-O
+2–5 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+the DET B-O
+mechanisms NOUN B-O
+of ADP B-O
+their PRON B-O
+mutagenesis NOUN B-O
+are AUX B-O
+not PART B-O
+completely ADV B-O
+understood VERB B-O
+. PUNCT B-O
+
+Further ADJ B-O
+kinetic ADJ B-O
+studies NOUN B-O
+allow VERB B-O
+the DET B-O
+first ADJ B-O
+snapshot NOUN B-O
+on ADP B-O
+how SCONJ B-O
+silver NOUN B-LF
+kills VERB B-O
+E. PROPN B-O
+coli NOUN B-O
+to PART B-O
+be AUX B-O
+captured VERB B-O
+at ADP B-O
+the DET B-O
+molecular ADJ B-O
+level NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+4C NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Ag+ PROPN B-AC
+, PUNCT B-O
+once ADV B-O
+uptaken VERB B-O
+inside ADP B-O
+E. PROPN B-O
+coli NOUN B-O
+cell NOUN B-O
+, PUNCT B-O
+primarily ADV B-O
+targets VERB B-O
+glycolysis NOUN B-O
+and CCONJ B-O
+the DET B-O
+oxidative ADJ B-O
+branch NOUN B-O
+of ADP B-O
+the DET B-O
+TCA PROPN B-AC
+cycle NOUN B-O
+( PUNCT B-O
+or CCONJ B-O
+pyruvate NOUN B-O
+cycle NOUN B-O
+) PUNCT B-O
+via ADP B-O
+functional ADJ B-O
+disruption NOUN B-O
+of ADP B-O
+the DET B-O
+key ADJ B-O
+enzymes NOUN B-O
+, PUNCT B-O
+followed VERB B-O
+by ADP B-O
+adaptive ADJ B-O
+glyoxylate NOUN B-O
+cycle NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+then ADV B-O
+abolishes VERB B-O
+bacterial ADJ B-O
+oxidative ADJ B-O
+defense NOUN B-O
+capability NOUN B-O
+through ADP B-O
+binding NOUN B-O
+and CCONJ B-O
+inactivation NOUN B-O
+of ADP B-O
+key ADJ B-O
+antioxidant ADJ B-O
+enzymes NOUN B-O
+. PUNCT B-O
+
+Second X B-O
+, PUNCT B-O
+we PRON B-O
+defined VERB B-O
+people NOUN B-O
+receiving VERB B-O
+long ADJ B-O
+- PUNCT B-O
+term NOUN B-O
+opioid NOUN B-LF
+pain NOUN I-LF
+therapy NOUN I-LF
+( PUNCT B-O
+OPT PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+those PRON B-O
+who PRON B-O
+had VERB B-O
+90 NUM B-O
+unique ADJ B-O
+days NOUN B-O
+of ADP B-O
+therapy NOUN B-O
+with ADP B-O
+opioids NOUN B-O
+indicated VERB B-O
+to ADP B-O
+treat VERB B-O
+pain NOUN B-O
+in ADP B-O
+the DET B-O
+100 NUM B-O
+days NOUN B-O
+prior ADV B-O
+to ADP B-O
+or CCONJ B-O
+including VERB B-O
+enrolment NOUN B-O
+termination NOUN B-O
+. PUNCT B-O
+
+Despite SCONJ B-O
+more ADJ B-O
+than ADP B-O
+two NUM B-O
+decades NOUN B-O
+of ADP B-O
+research NOUN B-O
+on ADP B-O
+adherence NOUN B-O
+to ADP B-O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+( PUNCT B-O
+ART PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+more ADJ B-O
+than ADP B-O
+17 NUM B-O
+million NUM B-O
+HIV PROPN B-O
+- PUNCT B-O
+positive ADJ B-O
+individuals NOUN B-O
+on ADP B-O
+treatment NOUN B-O
+, PUNCT B-O
+adherence NOUN B-O
+to ADP B-O
+ART PROPN B-AC
+remains VERB B-O
+a DET B-O
+major ADJ B-O
+challenge NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+further ADV B-O
+evaluate VERB B-O
+the DET B-O
+inhibitory ADJ B-O
+effects NOUN B-O
+of ADP B-O
+these DET B-O
+two NUM B-O
+compounds NOUN B-O
+on ADP B-O
+bacterial ADJ B-O
+growth NOUN B-O
+, PUNCT B-O
+the DET B-O
+compounds NOUN B-O
+were AUX B-O
+supplemented VERB B-O
+into ADP B-O
+the DET B-O
+culture NOUN B-O
+medium NOUN B-O
+of ADP B-O
+H. NOUN B-O
+pylori PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+pH NOUN B-O
+of ADP B-O
+brucella NOUN B-O
+broth NOUN B-O
+medium NOUN B-O
+was AUX B-O
+then ADV B-O
+adjusted VERB B-O
+to ADP B-O
+5.0 NUM B-O
+with ADP B-O
+sterile ADJ B-O
+dilute ADJ B-O
+hydrochloric ADJ B-LF
+acid NOUN I-LF
+( PUNCT B-O
+HCl PROPN B-AC
+) PUNCT B-O
+; PUNCT B-O
+inoculum NOUN B-O
+was AUX B-O
+added VERB B-O
+to ADP B-O
+an DET B-O
+initial ADJ B-O
+optical ADJ B-O
+density NOUN B-O
+at ADP B-O
+600 NUM B-O
+nm NOUN B-O
+( PUNCT B-O
+OD600 NUM B-O
+) PUNCT B-O
+of ADP B-O
+ca X B-O
+. PUNCT B-O
+
+0.1 NUM B-O
+. PUNCT B-O
+
+The DET B-O
+authors NOUN B-O
+, PUNCT B-O
+in ADP B-O
+a DET B-O
+previous ADJ B-O
+article NOUN B-O
+“ PUNCT B-O
+Recommendation NOUN B-O
+for ADP B-O
+ISTH PROPN B-O
+/ SYM B-O
+SSC PROPN B-O
+Criterion NOUN B-O
+2015 NUM B-O
+for ADP B-O
+autoimmune ADJ B-LF
+acquired VERB I-LF
+factor NOUN I-LF
+XIII/13 NUM I-LF
+deficiency NOUN I-LF
+” PUNCT B-O
+( PUNCT B-O
+Thromb PROPN B-O
+Haemost PROPN B-O
+2016 NUM B-O
+; PUNCT B-O
+116:772 NUM B-O
+- NUM B-O
+774 NUM B-O
+) PUNCT B-O
+refer VERB B-O
+to ADP B-O
+this DET B-O
+deficiency NOUN B-O
+as ADP B-O
+AAXIII/13D PROPN B-AC
+instead ADV B-O
+of ADP B-O
+AiF13D. NOUN B-O
+Children NOUN B-O
+were AUX B-O
+defined VERB B-O
+as ADP B-O
+being AUX B-O
+lost VERB B-LF
+to PART I-LF
+follow NOUN I-LF
+- PUNCT I-LF
+up ADP I-LF
+( PUNCT B-O
+LTFU PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+were AUX B-O
+censored VERB B-O
+if SCONJ B-O
+they PRON B-O
+had VERB B-O
+no DET B-O
+contact NOUN B-O
+with ADP B-O
+their PRON B-O
+health NOUN B-O
+care NOUN B-O
+facility NOUN B-O
+for ADP B-O
+9 NUM B-O
+mo NOUN B-O
+before ADP B-O
+database NOUN B-O
+closure NOUN B-O
+( PUNCT B-O
+visits NOUN B-O
+are AUX B-O
+scheduled VERB B-O
+up ADP B-O
+to PART B-O
+6 NUM B-O
+mo NOUN B-O
+apart ADV B-O
+and CCONJ B-O
+clinic NOUN B-O
+visits NOUN B-O
+being AUX B-O
+delayed VERB B-O
+for ADP B-O
+up ADP B-O
+to PART B-O
+3 NUM B-O
+mo NOUN B-O
+are AUX B-O
+possible ADJ B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+DDD PROPN B-AC
+, PUNCT B-O
+defined VERB B-LF
+daily ADJ I-LF
+dose NOUN I-LF
+. PUNCT B-O
+
+NP PROPN B-AC
+, PUNCT B-O
+normal ADJ B-LF
+pregnancy NOUN I-LF
+group NOUN B-O
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+observational ADJ B-O
+studies NOUN B-O
+of ADP B-O
+ITN PROPN B-AC
+use NOUN B-O
+have AUX B-O
+consistently ADV B-O
+shown VERB B-O
+findings NOUN B-O
+similar ADJ B-O
+to ADP B-O
+those PRON B-O
+of ADP B-O
+randomized VERB B-LF
+controlled VERB I-LF
+trials NOUN I-LF
+( PUNCT B-O
+RCTs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+suggesting VERB B-O
+that SCONJ B-O
+within ADP B-O
+specific ADJ B-O
+communities NOUN B-O
+confounding VERB B-O
+is AUX B-O
+not PART B-O
+pronounced VERB B-O
+[ PUNCT B-O
+29 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+On ADP B-O
+the DET B-O
+other ADJ B-O
+hand NOUN B-O
+, PUNCT B-O
+5-HT PROPN B-AC
+concentration NOUN B-O
+was AUX B-O
+significantly ADV B-O
+decreased VERB B-O
+in ADP B-O
+the DET B-O
+platelets NOUN B-O
+in ADP B-O
+patients NOUN B-O
+with ADP B-O
+AD PROPN B-AC
+[ X B-O
+54 X B-O
+] PUNCT B-O
+and CCONJ B-O
+selective ADJ B-O
+serotonin NOUN B-LF
+reuptake NOUN B-O
+inhibitors NOUN B-O
+improve VERB B-O
+decreased VERB B-O
+cognitive ADJ B-O
+performance NOUN B-O
+and CCONJ B-O
+BPSD PROPN B-AC
+seen VERB B-O
+in ADP B-O
+patients NOUN B-O
+with ADP B-O
+AD PROPN B-AC
+[ X B-O
+55 NUM B-O
+, PUNCT B-O
+56 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Pre X B-O
+= PUNCT B-O
+Precision NOUN B-O
+score NOUN B-O
+, PUNCT B-O
+Rec NOUN B-O
+= PUNCT B-O
+Recall NOUN B-O
+score NOUN B-O
+, PUNCT B-O
+F1 PROPN B-AC
+= PUNCT B-O
+F1 NOUN B-LF
+- PUNCT I-LF
+F1 PROPN B-AC
+score NOUN I-LF
+, PUNCT B-O
+AUC PROPN B-AC
+= PUNCT B-O
+AUC PROPN B-AC
+score NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+A(i NOUN B-O
+) PUNCT B-O
+= PUNCT B-O
+{ PUNCT B-O
+Prei NOUN B-O
+, PUNCT B-O
+Reci PROPN B-O
+, PUNCT B-O
+F1i X B-O
+, PUNCT B-O
+AUCi PROPN B-O
+} PUNCT B-O
+; PUNCT B-O
+w(i NOUN B-O
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+weight NOUN B-O
+generated VERB B-O
+for ADP B-O
+the DET B-O
+ith PROPN B-O
+base NOUN B-O
+learner NOUN B-O
+to PART B-O
+compute VERB B-O
+the DET B-O
+ensemble NOUN B-O
+, PUNCT B-O
+pj(i NOUN B-O
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+probability NOUN B-O
+score NOUN B-O
+for ADP B-O
+the DET B-O
+jth ADJ B-O
+sample NOUN B-O
+by ADP B-O
+the DET B-O
+ith PROPN B-O
+classifier NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+ensj NOUN B-O
+is AUX B-O
+the DET B-O
+fused VERB B-O
+probability NOUN B-O
+score NOUN B-O
+for ADP B-O
+the DET B-O
+jth ADJ B-O
+sample NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+the DET B-O
+argmax NOUN B-O
+function NOUN B-O
+returns VERB B-O
+the DET B-O
+position NOUN B-O
+having VERB B-O
+the DET B-O
+highest ADJ B-O
+value NOUN B-O
+in ADP B-O
+a DET B-O
+1D ADJ B-O
+array NOUN B-O
+, PUNCT B-O
+i.e. X B-O
+, PUNCT B-O
+in ADP B-O
+this DET B-O
+case NOUN B-O
+it PRON B-O
+generates VERB B-O
+the DET B-O
+predicted VERB B-O
+class NOUN B-O
+of ADP B-O
+the DET B-O
+sample NOUN B-O
+. PUNCT B-O
+
+This PRON B-O
+indicates VERB B-O
+that SCONJ B-O
+a DET B-O
+Chromosome NOUN B-O
+4 NUM B-O
+bivalent ADJ B-O
+experiences VERB B-O
+on ADP B-O
+average ADJ B-O
+1.76 NUM B-O
+CO PROPN B-AC
+in ADP B-O
+male ADJ B-LF
+meiosis NOUN B-O
+, PUNCT B-O
+but CCONJ B-O
+only ADV B-O
+1.05 NUM B-O
+CO PROPN B-AC
+in ADP B-O
+female ADJ B-LF
+meiosis NOUN B-O
+( PUNCT B-O
+M PROPN B-AC
+/ SYM B-O
+F PROPN B-AC
+ratio NOUN B-O
+1.68 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+results NOUN B-O
+in ADP B-O
+this DET B-O
+section NOUN B-O
+were AUX B-O
+confirmed VERB B-O
+by ADP B-O
+NCBI PROPN B-O
+’s PART B-O
+Conserved PROPN B-LF
+Domain PROPN I-LF
+Database PROPN I-LF
+( PUNCT B-O
+CDD PROPN B-AC
+) PUNCT B-O
+[ X B-O
+93 X B-O
+] X B-O
+matches NOUN B-O
+obtained VERB B-O
+using VERB B-O
+rpsblast PROPN B-O
+with ADP B-O
+composition NOUN B-O
+- PUNCT B-O
+based VERB B-O
+statistics NOUN B-O
+and CCONJ B-O
+masking VERB B-O
+low ADJ B-O
+- PUNCT B-O
+information NOUN B-O
+regions NOUN B-O
+. PUNCT B-O
+
+A X B-O
+range NOUN B-O
+of ADP B-O
+virulence NOUN B-O
+assays NOUN B-O
+were AUX B-O
+performed VERB B-O
+on ADP B-O
+a DET B-O
+subset NOUN B-O
+of ADP B-O
+10 NUM B-O
+high- ADJ B-O
+and CCONJ B-O
+10 NUM B-O
+low ADJ B-O
+- PUNCT B-O
+toxicity NOUN B-O
+isolates NOUN B-O
+from ADP B-O
+the DET B-O
+USA300 PROPN B-O
+collection NOUN B-O
+to PART B-O
+identify VERB B-O
+the DET B-O
+biological ADJ B-O
+feature NOUN B-O
+that PRON B-O
+explains VERB B-O
+the DET B-O
+observed VERB B-O
+inverse ADJ B-O
+correlation NOUN B-O
+between ADP B-O
+toxicity NOUN B-O
+and CCONJ B-O
+disease NOUN B-O
+severity NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+The DET B-O
+toxicity NOUN B-O
+of ADP B-O
+the DET B-O
+subset NOUN B-O
+of ADP B-O
+isolates NOUN B-O
+is AUX B-O
+provided VERB B-O
+for ADP B-O
+comparison NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+The DET B-O
+ability NOUN B-O
+of ADP B-O
+the DET B-O
+bacteria NOUN B-O
+to PART B-O
+invade VERB B-O
+EA.hy926 NOUN B-O
+endothelial ADJ B-O
+cells NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+C X B-O
+) PUNCT B-O
+The DET B-O
+ability NOUN B-O
+of ADP B-O
+the DET B-O
+bacteria NOUN B-O
+to PART B-O
+induce VERB B-O
+the DET B-O
+release NOUN B-O
+of ADP B-O
+neutrophil NOUN B-LF
+extracellular ADJ I-LF
+traps NOUN I-LF
+( PUNCT B-O
+NETs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D X B-O
+) PUNCT B-O
+The DET B-O
+release NOUN B-O
+of ADP B-O
+proteases NOUN B-O
+by ADP B-O
+the DET B-O
+bacteria NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+E X B-O
+) PUNCT B-O
+Resistance NOUN B-O
+of ADP B-O
+the DET B-O
+bacteria NOUN B-O
+to PART B-O
+human ADJ B-O
+neutrophil NOUN B-O
+defensin-1 NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+F X B-O
+) PUNCT B-O
+The DET B-O
+ability NOUN B-O
+of ADP B-O
+the DET B-O
+bacteria NOUN B-O
+to PART B-O
+form VERB B-O
+biofilms NOUN B-O
+. PUNCT B-O
+
+Although SCONJ B-O
+the DET B-O
+percentage NOUN B-O
+of ADP B-O
+women NOUN B-O
+attending VERB B-O
+Focused PROPN B-LF
+Antenatal PROPN I-LF
+Care PROPN I-LF
+( PUNCT B-O
+FANC PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+at ADP B-O
+least ADV B-O
+once ADV B-O
+generally ADV B-O
+tends VERB B-O
+to PART B-O
+be AUX B-O
+satisfactory ADJ B-O
+even ADV B-O
+in ADP B-O
+low ADJ B-O
+- PUNCT B-O
+income NOUN B-O
+countries NOUN B-O
+, PUNCT B-O
+maternal ADJ B-O
+and CCONJ B-O
+neonatal ADJ B-O
+mortality NOUN B-O
+remain VERB B-O
+high ADJ B-O
+. PUNCT B-O
+
+Cycloheximide NOUN B-O
+was AUX B-O
+added VERB B-O
+at ADP B-O
+time NOUN B-O
+= CCONJ B-O
+0 NUM B-O
+and CCONJ B-O
+the DET B-O
+amount NOUN B-O
+of ADP B-O
+Gal80 NOUN B-O
+protein NOUN B-O
+remaining VERB B-O
+in ADP B-O
+the DET B-O
+cells NOUN B-O
+after ADP B-O
+the DET B-O
+indicated VERB B-O
+number NOUN B-O
+of ADP B-O
+hours NOUN B-O
+was AUX B-O
+determined VERB B-O
+by ADP B-O
+Western ADJ B-O
+blot NOUN B-O
+with ADP B-O
+the DET B-O
+help NOUN B-O
+of ADP B-O
+an DET B-O
+anti ADJ B-O
+- ADJ B-O
+hemagglutinin ADJ B-LF
+( PUNCT B-O
+HA PROPN B-AC
+) PUNCT B-O
+antibody NOUN B-O
+( PUNCT B-O
+upper ADJ B-O
+panels NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Dpp PROPN B-AC
+, PUNCT B-O
+Decapentaplegic PROPN B-LF
+; PUNCT B-O
+Hh PROPN B-AC
+, PUNCT B-O
+Hedgehog PROPN B-LF
+. PUNCT B-O
+
+The DET B-O
+most ADV B-O
+common ADJ B-O
+alternative ADJ B-O
+infectious ADJ B-LF
+disease NOUN I-LF
+( PUNCT B-O
+ID)—diagnoses PROPN B-AC
+were AUX B-O
+pneumonia NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= PUNCT B-O
+30 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+infection NOUN B-O
+of ADP B-O
+totally ADV B-O
+implantable ADJ B-O
+venous ADJ B-O
+access NOUN B-O
+device NOUN B-O
+( PUNCT B-O
+port NOUN B-O
+, PUNCT B-O
+n NOUN B-O
+= PUNCT B-O
+9 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+skin NOUN B-LF
+and CCONJ I-LF
+soft ADJ I-LF
+tissue NOUN I-LF
+infection NOUN I-LF
+( PUNCT B-O
+SSTI PROPN B-AC
+, PUNCT B-O
+n NOUN B-O
+= PUNCT B-O
+9 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+influenza NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= PUNCT B-O
+4 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Lysates NOUN B-O
+derived VERB B-O
+from ADP B-O
+virions NOUN B-O
+containing VERB B-O
+HA PROPN B-O
+- PUNCT B-O
+tagged VERB B-O
+A3G PROPN B-AC
+were AUX B-O
+size NOUN B-O
+- PUNCT B-O
+fractionated VERB B-O
+by ADP B-O
+fast ADJ B-LF
+protein NOUN I-LF
+liquid NOUN I-LF
+chromatography NOUN I-LF
+( PUNCT B-O
+FPLC PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Each DET B-O
+fraction NOUN B-O
+was AUX B-O
+then ADV B-O
+analyzed VERB B-O
+by ADP B-O
+SDS PROPN B-O
+- PUNCT B-O
+PAGE PROPN B-O
+and CCONJ B-O
+immunoblotting VERB B-O
+with ADP B-O
+anti ADJ B-O
+- PUNCT B-O
+HA PROPN B-O
+monoclonal ADJ B-O
+antibodies NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+3A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Surprisingly ADV B-O
+, PUNCT B-O
+virion NOUN B-O
+- PUNCT B-O
+incorporated VERB B-O
+HA PROPN B-O
+- PUNCT B-O
+A3 PROPN B-AC
+was AUX B-O
+detected VERB B-O
+almost ADV B-O
+exclusively ADV B-O
+in ADP B-O
+the DET B-O
+GHMM PROPN B-AC
+region NOUN B-O
+, PUNCT B-O
+eluting VERB B-O
+in ADP B-O
+the DET B-O
+void ADJ B-O
+volume NOUN B-O
+of ADP B-O
+the DET B-O
+Superose PROPN B-O
+6 NUM B-O
+column NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+3A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+result NOUN B-O
+was AUX B-O
+not PART B-O
+due ADJ B-O
+to ADP B-O
+incomplete ADJ B-O
+lysis NOUN B-O
+of ADP B-O
+the DET B-O
+virion NOUN B-O
+cores NOUN B-O
+since SCONJ B-O
+the DET B-O
+p24 NOUN B-O
+viral ADJ B-O
+capsid NOUN B-LF
+( PUNCT B-O
+p24 NOUN B-O
+- PUNCT B-O
+CA PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+detected VERB B-O
+only ADV B-O
+in ADP B-O
+the DET B-O
+expected VERB B-O
+LMM PROPN B-AC
+fractions NOUN B-O
+. PUNCT B-O
+
+Inward ADJ B-LF
+rectifier NOUN I-LF
+potassium NOUN I-LF
+current NOUN I-LF
+( PUNCT B-O
+IK1 PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+measured VERB B-O
+by ADP B-O
+determining VERB B-O
+the DET B-O
+steady ADJ B-O
+- PUNCT B-O
+state NOUN B-O
+current NOUN B-O
+at ADP B-O
+the DET B-O
+end NOUN B-O
+of ADP B-O
+300 NUM B-O
+ms NOUN B-O
+long ADJ B-O
+pulses NOUN B-O
+clamped VERB B-O
+to ADP B-O
+potentials NOUN B-O
+ranging VERB B-O
+from ADP B-O
+-80 NUM B-O
+to ADP B-O
+0 NUM B-O
+mV. NOUN B-O
+FFS PROPN B-AC
+, PUNCT B-O
+Medicare PROPN B-LF
+fee NOUN I-LF
+- PUNCT I-LF
+for ADP I-LF
+- PUNCT I-LF
+service NOUN I-LF
+; PUNCT B-O
+IPTW PROPN B-AC
+, PUNCT B-O
+inverse ADJ B-LF
+probability NOUN I-LF
+of ADP I-LF
+treatment NOUN I-LF
+weighting NOUN I-LF
+; PUNCT B-O
+MA PROPN B-AC
+, PUNCT B-O
+Medicare PROPN B-LF
+Advantage PROPN I-LF
+; PUNCT B-O
+SNF PROPN B-AC
+, PUNCT B-O
+skilled ADJ B-LF
+nursing NOUN I-LF
+facility NOUN I-LF
+. PUNCT B-O
+
+Weak ADJ B-O
+CGIs PROPN B-AC
+may AUX B-O
+be AUX B-O
+depleted VERB B-O
+because SCONJ B-O
+they PRON B-O
+are AUX B-O
+heavily ADV B-O
+methylated VERB B-O
+and CCONJ B-O
+therefore ADV B-O
+not PART B-O
+enriched VERB B-O
+by ADP B-O
+CAP PROPN B-AC
+. PUNCT B-O
+
+Indeed ADV B-O
+, PUNCT B-O
+22 NUM B-O
+methylated VERB B-O
+weak ADJ B-O
+CpG NOUN B-LF
+islands NOUN I-LF
+[ X B-O
+14 X B-O
+] X B-O
+were AUX B-O
+not PART B-O
+detected VERB B-O
+in ADP B-O
+our PRON B-O
+library NOUN B-O
+. PUNCT B-O
+
+Thus ADV B-O
+, PUNCT B-O
+it PRON B-O
+is AUX B-O
+necessary ADJ B-O
+to PART B-O
+test VERB B-O
+our PRON B-O
+hypothesis NOUN B-O
+that SCONJ B-O
+the DET B-O
+treatment NOUN B-O
+of ADP B-O
+stroke NOUN B-O
+with ADP B-O
+BMSC PROPN B-AC
+has AUX B-O
+therapeutic ADJ B-O
+efficacy NOUN B-O
+in ADP B-O
+the DET B-O
+most ADV B-O
+common ADJ B-O
+form NOUN B-O
+of ADP B-O
+diabetes NOUN B-O
+, PUNCT B-O
+type NOUN B-LF
+2 NUM I-LF
+diabetes NOUN I-LF
+mellitus NOUN I-LF
+( PUNCT B-O
+T2DM PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+T2DM PROPN B-AC
+was AUX B-O
+induced VERB B-O
+in ADP B-O
+adult ADJ B-O
+male ADJ B-O
+Wistar PROPN B-O
+rats NOUN B-O
+by ADP B-O
+administration NOUN B-O
+of ADP B-O
+a DET B-O
+high ADJ B-O
+fat NOUN B-O
+diet NOUN B-O
+in ADP B-O
+combination NOUN B-O
+with ADP B-O
+a DET B-O
+single ADJ B-O
+intraperitoneal ADJ B-O
+injection NOUN B-O
+( PUNCT B-O
+35mg NUM B-O
+/ SYM B-O
+kg NOUN B-O
+) PUNCT B-O
+of ADP B-O
+streptozotocin NOUN B-O
+. PUNCT B-O
+
+There PRON B-O
+are AUX B-O
+eight NUM B-O
+mammalian ADJ B-O
+IAPs NOUN B-O
+. PUNCT B-O
+
+Some DET B-O
+IAPs NOUN B-O
+also ADV B-O
+contain VERB B-O
+a DET B-O
+RING NOUN B-O
+motif NOUN B-O
+that PRON B-O
+confers VERB B-O
+ubiquitin NOUN B-O
+protein NOUN B-O
+ligase NOUN B-O
+( PUNCT B-O
+E3 NOUN B-O
+) PUNCT B-O
+activity NOUN B-O
+. PUNCT B-O
+
+c NOUN B-O
+- PUNCT B-O
+IAP1 PROPN B-O
+and CCONJ B-O
+c NOUN B-O
+- PUNCT B-O
+IAP2 PROPN B-O
+are AUX B-O
+such ADJ B-O
+RING NOUN B-O
+- PUNCT B-O
+containing VERB B-O
+proteins NOUN B-O
+that PRON B-O
+bind VERB B-O
+caspase-7 NOUN B-O
+or CCONJ B-O
+-9 NUM B-O
+but CCONJ B-O
+, PUNCT B-O
+unlike ADP B-O
+XIAP PROPN B-O
+, PUNCT B-O
+do AUX B-O
+not PART B-O
+inhibit VERB B-O
+their PRON B-O
+enzymatic ADJ B-O
+activities NOUN B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+c NOUN B-O
+- PUNCT B-O
+IAP1 PROPN B-O
+and CCONJ B-O
+c NOUN B-O
+- PUNCT B-O
+IAP2 PROPN B-O
+also ADV B-O
+bind VERB B-O
+the DET B-O
+adaptor NOUN B-O
+protein NOUN B-O
+TNF PROPN B-LF
+Receptor PROPN I-LF
+Associated PROPN I-LF
+Factor PROPN I-LF
+2 NUM I-LF
+( PUNCT B-O
+TRAF2 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+are AUX B-O
+components NOUN B-O
+of ADP B-O
+the DET B-O
+Tumor PROPN B-LF
+Necrosis PROPN I-LF
+Factor PROPN I-LF
+Receptor PROPN I-LF
+1 NUM I-LF
+( PUNCT B-O
+TNF-R1 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+2 NUM B-O
+signaling NOUN B-O
+complexes NOUN B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Fig NOUN B-O
+1A–1C NOUN B-O
+shows VERB B-O
+that SCONJ B-O
+hearts NOUN B-O
+exposed VERB B-O
+to ADP B-O
+40 NUM B-O
+minutes NOUN B-O
+of ADP B-O
+ischemia NOUN B-O
+and CCONJ B-O
+60 NUM B-O
+minutes NOUN B-O
+of ADP B-O
+reperfusion NOUN B-O
+( PUNCT B-O
+I/R PROPN B-AC
+) PUNCT B-O
+suffered VERB B-O
+a DET B-O
+significant ADJ B-O
+decrease NOUN B-O
+in ADP B-O
+the DET B-O
+left ADJ B-LF
+ventricular ADJ I-LF
+developed VERB I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+LVDP PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+well ADV B-O
+as ADP B-O
+in ADP B-O
+the DET B-O
+positive ADJ B-O
+and CCONJ B-O
+negative ADJ B-O
+maximum ADJ B-O
+derivative NOUN B-LF
+of ADP I-LF
+left ADJ I-LF
+ventricular ADJ I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+±dP NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+indicating VERB B-O
+significant ADJ B-O
+loss NOUN B-O
+in ADP B-O
+heart NOUN B-O
+function NOUN B-O
+. PUNCT B-O
+
+CK-666 PROPN B-AC
+, PUNCT B-O
+Arp2/3 NOUN B-LF
+complex NOUN I-LF
+Arp2/3 PROPN B-AC
+inhibitor NOUN I-LF
+I. NOUN I-LF
+Data NOUN B-O
+are AUX B-O
+shown VERB B-O
+as ADP B-O
+mean NOUN B-O
+± ADJ B-O
+SEM NOUN B-O
+. PUNCT B-O
+
+AAV PROPN B-O
+, PUNCT B-O
+adeno NOUN B-O
+- PUNCT B-O
+associated VERB B-O
+virus NOUN B-O
+; PUNCT B-O
+ARC PROPN B-AC
+, PUNCT B-O
+arcuate ADJ B-LF
+nucleus NOUN I-LF
+of ADP I-LF
+the DET I-LF
+hypothalamus NOUN I-LF
+; PUNCT B-O
+cap NOUN B-O
+, PUNCT B-O
+capsaicin NOUN B-O
+; PUNCT B-O
+CNO PROPN B-AC
+, PUNCT B-O
+clozapine NOUN B-LF
+- PUNCT I-LF
+N NOUN I-LF
+- PUNCT I-LF
+oxide NOUN I-LF
+; PUNCT B-O
+Cre PROPN B-AC
+, PUNCT B-O
+Cre PROPN B-LF
+recombinase NOUN I-LF
+Cre PROPN B-AC
+; PUNCT B-O
+DREADD PROPN B-AC
+, PUNCT B-O
+designer NOUN B-LF
+receptor NOUN I-LF
+exclusively ADV I-LF
+activated VERB I-LF
+by ADP I-LF
+designer NOUN I-LF
+drugs NOUN I-LF
+; PUNCT B-O
+hSyn PROPN B-AC
+, PUNCT B-O
+human ADJ B-LF
+synapsin NOUN I-LF
+I NUM I-LF
+promoter NOUN I-LF
+; PUNCT B-O
+i.p NOUN B-O
+. PUNCT B-O
+
+, PUNCT B-O
+Intraperitoneal NOUN B-O
+; PUNCT B-O
+mCherry PROPN B-AC
+, PUNCT B-O
+monomeric ADJ B-LF
+cherry NOUN I-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+MC3/4 PROPN B-O
+, PUNCT B-O
+melanocortin NOUN B-O
+3/4 NUM B-O
+; PUNCT B-O
+POMC PROPN B-AC
+, PUNCT B-O
+proopiomelanocortin NOUN B-LF
+; PUNCT B-O
+RTX PROPN B-AC
+, PUNCT B-O
+resiniferatoxin NOUN B-LF
+; PUNCT B-O
+sal NOUN B-O
+, PUNCT B-O
+saline NOUN B-O
+; PUNCT B-O
+TRPV1 PROPN B-AC
+, PUNCT B-O
+transient ADJ B-LF
+receptor NOUN I-LF
+potential ADJ I-LF
+vanilloid NOUN I-LF
+1 NUM I-LF
+receptor NOUN I-LF
+. PUNCT B-O
+
+Targeted VERB B-LF
+radionuclide NOUN I-LF
+therapy NOUN I-LF
+( PUNCT B-O
+TRNT PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+alpha NOUN B-O
+particles NOUN B-O
+is AUX B-O
+thus ADV B-O
+complementary ADJ B-O
+to ADP B-O
+TRNT PROPN B-AC
+with ADP B-O
+beta NOUN B-O
+particles NOUN B-O
+, PUNCT B-O
+whose DET B-O
+millimetric ADJ B-O
+path NOUN B-O
+is AUX B-O
+better ADV B-O
+suited ADJ B-O
+to ADP B-O
+bulky ADJ B-O
+tumour NOUN B-O
+treatment NOUN B-O
+. PUNCT B-O
+
+One NUM B-O
+part NOUN B-O
+is AUX B-O
+called VERB B-O
+GP PROPN B-AC
+( PUNCT B-O
+which PRON B-O
+stands VERB B-O
+for ADP B-O
+glycoprotein NOUN B-LF
+) PUNCT B-O
+and CCONJ B-O
+is AUX B-O
+from ADP B-O
+the DET B-O
+outer ADJ B-O
+coat NOUN B-O
+of ADP B-O
+the DET B-O
+virus NOUN B-O
+; PUNCT B-O
+the DET B-O
+other ADJ B-O
+, PUNCT B-O
+NP PROPN B-AC
+( PUNCT B-O
+nucleoprotein NOUN B-LF
+) PUNCT B-O
+, PUNCT B-O
+is AUX B-O
+from ADP B-O
+its PRON B-O
+inside NOUN B-O
+. PUNCT B-O
+
+Bioreactors NOUN B-O
+were AUX B-O
+filled VERB B-O
+with ADP B-O
+different ADJ B-O
+mixtures NOUN B-O
+of ADP B-O
+WAS PROPN B-AC
+substrate NOUN B-O
+and CCONJ B-O
+a DET B-O
+co NOUN B-O
+- NOUN B-O
+substrate NOUN B-O
+( PUNCT B-O
+FW PROPN B-AC
+or CCONJ B-O
+GG PROPN B-AC
+) PUNCT B-O
+prepared VERB B-O
+in ADP B-O
+different ADJ B-O
+proportions NOUN B-O
+of ADP B-O
+grams NOUN B-O
+of ADP B-O
+chemical ADJ B-LF
+oxygen NOUN I-LF
+demand NOUN I-LF
+( PUNCT B-O
+COD PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+These DET B-O
+proportions NOUN B-O
+consisted VERB B-O
+of ADP B-O
+0/100 NUM B-O
+, PUNCT B-O
+25/75 NUM B-O
+, PUNCT B-O
+50/50 NUM B-O
+, PUNCT B-O
+75/25 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+100/0 NUM B-O
+gCOD NOUN B-O
+WAS PROPN B-AC
+/ SYM B-O
+gCOD NOUN B-O
+co NOUN B-O
+- NOUN B-O
+substrate NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+appraised VERB B-O
+the DET B-O
+certainty NOUN B-O
+of ADP B-O
+the DET B-O
+key ADJ B-O
+elements NOUN B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+Grading PROPN B-LF
+of ADP I-LF
+Recommendations PROPN I-LF
+Assessment PROPN I-LF
+, PUNCT I-LF
+Development PROPN I-LF
+and CCONJ I-LF
+Evaluation PROPN I-LF
+( PUNCT B-O
+GRADE PROPN B-AC
+) PUNCT B-O
+tool NOUN B-O
+[ PUNCT B-O
+29–31 NUM B-O
+] X B-O
+( PUNCT B-O
+S3 PROPN B-O
+Table NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+H PROPN B-AC
+’s PART B-O
+Byproduct NOUN B-LF
+B PROPN B-AC
+is AUX B-O
+required VERB B-O
+by ADP B-O
+Manufacturer NOUN B-LF
+FISH PROPN B-AC
+, PUNCT B-O
+fluorescence NOUN B-LF
+in ADP I-LF
+situ ADJ I-LF
+hybridization NOUN I-LF
+; PUNCT B-O
+SIM PROPN B-AC
+, PUNCT B-O
+structured ADJ B-LF
+illumination NOUN I-LF
+microscopy NOUN I-LF
+; PUNCT B-O
+WT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+type NOUN I-LF
+. PUNCT B-O
+
+AMP NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+AMPK PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+an DET B-O
+evolutionarily ADV B-O
+- PUNCT B-O
+conserved VERB B-O
+fuel NOUN B-O
+- PUNCT B-O
+sensitive ADJ B-O
+serine NOUN B-O
+/ SYM B-O
+threonine NOUN B-O
+protein NOUN B-O
+kinase NOUN B-O
+and CCONJ B-O
+cellular ADJ B-O
+nutrient NOUN B-O
+sensor NOUN B-O
+implicated VERB B-O
+in ADP B-O
+the DET B-O
+regulation NOUN B-O
+of ADP B-O
+energy NOUN B-O
+homeostasis NOUN B-O
+[ PUNCT B-O
+19 X B-O
+] PUNCT B-O
+[ PUNCT B-O
+20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Such ADJ B-O
+measurement NOUN B-O
+results VERB B-O
+in ADP B-O
+various ADJ B-O
+coupling NOUN B-O
+metrics NOUN B-O
+, PUNCT B-O
+which PRON B-O
+can AUX B-O
+be AUX B-O
+considered VERB B-O
+as ADP B-O
+assessor NOUN B-O
+of ADP B-O
+design NOUN B-O
+stability NOUN B-O
+of ADP B-O
+classes NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+Coupling NOUN B-LF
+Between ADP I-LF
+Object PROPN I-LF
+( PUNCT B-O
+CBO PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Response NOUN B-LF
+For ADP I-LF
+a DET I-LF
+Class NOUN I-LF
+( PUNCT B-O
+RFC PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+Chidamber PROPN B-O
+and CCONJ B-O
+Kemerer PROPN B-O
+’s PART B-O
+metrics NOUN B-O
+suit VERB B-O
+[ PUNCT B-O
+9 NUM B-O
+, PUNCT B-O
+11 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+Data PROPN B-LF
+Abstraction NOUN I-LF
+Coupling NOUN I-LF
+( PUNCT B-O
+DAC PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Measure NOUN B-LF
+of ADP I-LF
+Aggregation NOUN I-LF
+( PUNCT B-O
+MOA PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+QMOOD PROPN B-O
+[ PUNCT B-O
+10 NUM B-O
+] PUNCT B-O
+and CCONJ B-O
+Message NOUN B-LF
+Passing NOUN I-LF
+Coupling NOUN I-LF
+( PUNCT B-O
+MPC PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+12 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Peripheral ADJ B-O
+blood NOUN B-O
+mononuclear ADJ B-O
+cells NOUN B-O
+from ADP B-O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+( PUNCT B-O
+ICU PROPN B-AC
+) PUNCT B-O
+patients NOUN B-O
+with ADP B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+30 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+without ADP B-O
+sepsis NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+10 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+healthy ADJ B-O
+volunteers NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+15 NUM B-O
+) PUNCT B-O
+were AUX B-O
+isolated VERB B-O
+using VERB B-O
+Ficoll PROPN B-O
+density NOUN B-O
+gradient NOUN B-O
+centrifugation NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+data NOUN B-O
+were AUX B-O
+then ADV B-O
+separated VERB B-O
+into ADP B-O
+local ADJ B-LF
+field NOUN I-LF
+potentials NOUN I-LF
+( PUNCT B-O
+LFPs PROPN B-AC
+; PUNCT B-O
+1–150 NUM B-O
+Hz NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+isolated VERB B-O
+single ADJ B-O
+- PUNCT B-O
+unit NOUN B-O
+activity NOUN B-O
+( PUNCT B-O
+0.5–10 NUM B-O
+kHz NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Prostate ADJ B-LF
+cancer NOUN I-LF
+( PUNCT B-O
+PCa PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+most ADV B-O
+common ADJ B-O
+malignancy NOUN B-O
+in ADP B-O
+men NOUN B-O
+and CCONJ B-O
+is AUX B-O
+the DET B-O
+second ADJ B-O
+leading VERB B-O
+cause NOUN B-O
+of ADP B-O
+cancer NOUN B-O
+deaths NOUN B-O
+worldwide ADV B-O
+. PUNCT B-O
+
+Whereas SCONJ B-O
+the DET B-O
+impact NOUN B-O
+of ADP B-O
+the DET B-O
+G PROPN B-O
+allele NOUN B-O
+on ADP B-O
+the DET B-O
+liver NOUN B-O
+fibrosis NOUN B-O
+progression NOUN B-O
+in ADP B-O
+chronic ADJ B-O
+hepatitis NOUN B-O
+C PROPN B-O
+seems VERB B-O
+to PART B-O
+be AUX B-O
+well ADV B-O
+known VERB B-O
+, PUNCT B-O
+its PRON B-O
+impact NOUN B-O
+on ADP B-O
+chronic ADJ B-LF
+liver NOUN I-LF
+failure NOUN I-LF
+( PUNCT B-O
+CLF PROPN B-AC
+) PUNCT B-O
+progression NOUN B-O
+and CCONJ B-O
+the DET B-O
+need NOUN B-O
+of ADP B-O
+LT PROPN B-AC
+has AUX B-O
+not PART B-O
+been AUX B-O
+described VERB B-O
+so ADV B-O
+far ADV B-O
+. PUNCT B-O
+
+First ADV B-O
+, PUNCT B-O
+S PROPN B-AC
+forms VERB B-O
+Watson PROPN B-O
+– PUNCT B-O
+Crick PROPN B-O
+base NOUN B-O
+pairs NOUN B-O
+with ADP B-O
+the DET B-O
+ribozyme NOUN B-LF
+'s PART B-O
+internal ADJ B-O
+guide NOUN B-O
+sequence NOUN B-O
+( PUNCT B-O
+see VERB B-O
+Figure PROPN B-O
+2A NUM B-O
+) PUNCT B-O
+to PART B-O
+give VERB B-O
+the DET B-O
+open ADJ B-O
+complex NOUN B-O
+( PUNCT B-O
+In ADP B-O
+total NOUN B-O
+, PUNCT B-O
+these DET B-O
+US PROPN B-O
+healthcare NOUN B-O
+- PUNCT B-O
+related VERB B-O
+emissions NOUN B-O
+result VERB B-O
+in ADP B-O
+an DET B-O
+estimated VERB B-O
+annual ADJ B-O
+loss NOUN B-O
+of ADP B-O
+614,000 NUM B-O
+disability NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+years NOUN I-LF
+( PUNCT B-O
+DALYs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+only ADJ B-O
+such ADJ B-O
+national ADJ B-O
+damage NOUN B-O
+estimate NOUN B-O
+to ADP B-O
+date NOUN B-O
+[ PUNCT B-O
+7,24 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+For ADP B-O
+example NOUN B-O
+, PUNCT B-O
+one NUM B-O
+pair NOUN B-O
+from ADP B-O
+this DET B-O
+region NOUN B-O
+is AUX B-O
+shown VERB B-O
+to ADP B-O
+be AUX B-O
+expressed VERB B-O
+from ADP B-O
+chromosome NOUN B-O
+8q24.21 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+it PRON B-O
+forms VERB B-O
+a DET B-O
+stable ADJ B-O
+ndsRNA PROPN B-AC
+molecule NOUN B-O
+( PUNCT B-O
+nds-2a NOUN B-O
+) PUNCT B-O
+that PRON B-O
+binds VERB B-O
+to ADP B-O
+regulator NOUN B-LF
+of ADP I-LF
+chromosome NOUN I-LF
+condensation NOUN I-LF
+1 NUM I-LF
+( PUNCT B-O
+RCC1 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+ras NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+nuclear ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+RAN PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+through ADP B-O
+the DET B-O
+latter ADJ B-O
+, PUNCT B-O
+with ADP B-O
+the DET B-O
+mitotic ADJ B-O
+RANGAP1 NOUN B-O
+- PUNCT B-O
+SUMO1 NOUN B-O
+- PUNCT B-O
+RANBP2 NOUN B-O
+complex NOUN B-O
+[ PUNCT B-O
+64 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+gene NOUN B-O
+expression NOUN B-O
+of ADP B-O
+FA PROPN B-AC
+synthase NOUN B-O
+( PUNCT B-O
+FASN PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+lipoprotein NOUN B-LF
+lipase NOUN I-LF
+( PUNCT B-O
+LPL PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+stearoyl NOUN B-O
+- PUNCT B-O
+CoA NOUN B-O
+desaturase NOUN B-O
+( PUNCT B-O
+SCD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+FA PROPN B-AC
+desaturase NOUN B-O
+1 NUM B-O
+( PUNCT B-O
+FADS1 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+FA PROPN B-AC
+elongase NOUN B-O
+5 NUM B-O
+( PUNCT B-O
+ELOVL5 PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+measured VERB B-O
+in ADP B-O
+muscle NOUN B-O
+. PUNCT B-O
+
+Interactions NOUN B-O
+of ADP B-O
+MYPT1 PROPN B-AC
+and CCONJ B-O
+its PRON B-O
+mutants NOUN B-O
+with ADP B-O
+SNAP-25 PROPN B-AC
+were AUX B-O
+analysed VERB B-O
+by ADP B-O
+surface NOUN B-LF
+plasmon NOUN I-LF
+resonance NOUN I-LF
+( PUNCT B-O
+SPR PROPN B-AC
+) PUNCT B-O
+using VERB B-O
+a DET B-O
+Biacore PROPN B-O
+3000 NUM B-O
+instrument NOUN B-O
+( PUNCT B-O
+GE PROPN B-O
+Healthcare PROPN B-O
+, PUNCT B-O
+Little PROPN B-O
+Chalfont PROPN B-O
+, PUNCT B-O
+UK PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Anti NOUN B-O
+- PUNCT B-O
+GST PROPN B-O
+was AUX B-O
+coupled VERB B-O
+on ADP B-O
+the DET B-O
+surface NOUN B-O
+of ADP B-O
+a DET B-O
+CM5 PROPN B-O
+chip NOUN B-O
+by ADP B-O
+amine NOUN B-O
+- PUNCT B-O
+coupling NOUN B-O
+, PUNCT B-O
+then ADV B-O
+full ADJ B-O
+- PUNCT B-O
+length ADJ B-O
+GST PROPN B-O
+- PUNCT B-O
+MYPT1WT NOUN B-O
+or CCONJ B-O
+its PRON B-O
+C NOUN B-O
+- PUNCT B-O
+terminal NOUN B-O
+fragment NOUN B-O
+( PUNCT B-O
+GST PROPN B-O
+- PUNCT B-O
+MYPT1667–1004 PROPN B-O
+) PUNCT B-O
+was AUX B-O
+captured VERB B-O
+on ADP B-O
+the DET B-O
+surface NOUN B-O
+. PUNCT B-O
+
+Our PRON B-O
+estimates NOUN B-O
+( PUNCT B-O
+black ADJ B-O
+) PUNCT B-O
+of ADP B-O
+the DET B-O
+excess ADJ B-LF
+hazard NOUN I-LF
+- PUNCT I-LF
+months NOUN I-LF
+attributable ADJ I-LF
+to ADP I-LF
+the DET I-LF
+acute ADJ I-LF
+phase NOUN I-LF
+( PUNCT B-O
+EHMacute PROPN B-AC
+) PUNCT B-O
+based VERB B-O
+on ADP B-O
+( PUNCT B-O
+A NOUN B-O
+) PUNCT B-O
+viral ADJ B-O
+load NOUN B-O
+trajectories NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+. PUNCT B-O
+
+2 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+our PRON B-O
+fit NOUN B-O
+of ADP B-O
+a DET B-O
+couples NOUN B-O
+transmission NOUN B-O
+model NOUN B-O
+to ADP B-O
+the DET B-O
+Rakai PROPN B-O
+retrospective ADJ B-O
+cohort NOUN B-O
+. PUNCT B-O
+
+These PRON B-O
+comprise VERB B-O
+: PUNCT B-O
+release NOUN B-O
+from ADP B-O
+chaperones NOUN B-O
+and CCONJ B-O
+co NOUN B-O
+- PUNCT B-O
+chaperones NOUN B-O
+, PUNCT B-O
+trimerization NOUN B-O
+via ADP B-O
+an DET B-O
+unmasked ADJ B-O
+coiled VERB B-O
+- PUNCT B-O
+coil NOUN B-O
+domain NOUN B-O
+, PUNCT B-O
+binding NOUN B-O
+to ADP B-O
+its PRON B-O
+cognate NOUN B-O
+DNA NOUN B-O
+sequences NOUN B-O
+in ADP B-O
+regulatory ADJ B-O
+regions NOUN B-O
+of ADP B-O
+target NOUN B-O
+genes NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+stimulation NOUN B-O
+of ADP B-O
+the DET B-O
+transactivation NOUN B-O
+potential NOUN B-O
+via ADP B-O
+the DET B-O
+calcium NOUN B-LF
+/ SYM I-LF
+calmodulin NOUN I-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+kinase NOUN I-LF
+II NUM I-LF
+( PUNCT B-O
+CAMKII)-mediated PROPN B-AC
+phosphorylation NOUN B-O
+of ADP B-O
+a DET B-O
+serine NOUN B-O
+residue NOUN B-O
+within ADP B-O
+the DET B-O
+HSF1 PROPN B-O
+regulatory ADJ B-O
+domain NOUN B-O
+[ PUNCT B-O
+38 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Patients NOUN B-O
+with ADP B-O
+hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+( PUNCT B-O
+HCC PROPN B-AC
+) PUNCT B-O
+submitted VERB B-O
+to ADP B-O
+orthotopic ADJ B-LF
+liver NOUN I-LF
+transplantation NOUN I-LF
+( PUNCT B-O
+OLT PROPN B-AC
+) PUNCT B-O
+have VERB B-O
+a DET B-O
+variable ADJ B-O
+5 NUM B-O
+- PUNCT B-O
+year NOUN B-O
+survival NOUN B-O
+rate NOUN B-O
+limited VERB B-O
+mostly ADV B-O
+by ADP B-O
+tumor NOUN B-O
+recurrence NOUN B-O
+. PUNCT B-O
+
+All DET B-O
+data NOUN B-O
+in ADP B-O
+this DET B-O
+study NOUN B-O
+are AUX B-O
+computed VERB B-O
+with ADP B-O
+their PRON B-O
+95 NUM B-O
+% NOUN B-O
+uncertainty NOUN B-LF
+intervals NOUN I-LF
+( PUNCT B-O
+UIs PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+13–17 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+oxidative ADJ B-O
+fluorescent ADJ B-O
+dye NOUN B-O
+, PUNCT B-O
+DHE PROPN B-AC
+, PUNCT B-O
+was AUX B-O
+freely ADV B-O
+permeable ADJ B-O
+to ADP B-O
+cells NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+O2- NOUN B-O
+was AUX B-O
+oxidized VERB B-O
+to ADP B-O
+ethidium NOUN B-LF
+bromide NOUN I-LF
+( PUNCT B-O
+EtBr PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+was AUX B-O
+trapped VERB B-O
+by ADP B-O
+intercalation NOUN B-O
+with ADP B-O
+DNA PROPN B-O
+. PUNCT B-O
+
+EtBr PROPN B-AC
+was AUX B-O
+excited VERB B-O
+at ADP B-O
+488 NUM B-O
+nm NOUN B-O
+with ADP B-O
+an DET B-O
+emission NOUN B-O
+spectrum NOUN B-O
+of ADP B-O
+610 NUM B-O
+nm NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+physiological ADJ B-O
+factors NOUN B-O
+which PRON B-O
+affect VERB B-O
+left ADJ B-LF
+ventricular ADJ I-LF
+( PUNCT B-O
+LV PROPN B-AC
+) PUNCT B-O
+long ADJ B-O
+- PUNCT B-O
+axis NOUN B-O
+function NOUN B-O
+are AUX B-O
+not PART B-O
+fully ADV B-O
+defined VERB B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+AM PROPN B-AC
+, PUNCT B-O
+acute ADJ B-LF
+malnutrition NOUN I-LF
+; PUNCT B-O
+BCC PROPN B-AC
+, PUNCT B-O
+behavior NOUN B-LF
+change NOUN I-LF
+communication NOUN I-LF
+; PUNCT B-O
+CMAM PROPN B-AC
+, PUNCT B-O
+community NOUN B-O
+management NOUN B-O
+of ADP B-O
+AM PROPN B-AC
+; PUNCT B-O
+CNS PROPN B-AC
+, PUNCT B-O
+well ADJ B-O
+- PUNCT B-O
+baby NOUN B-O
+consultation NOUN B-O
+; PUNCT B-O
+MAM PROPN B-AC
+, PUNCT B-O
+moderate ADJ B-O
+AM PROPN B-AC
+; PUNCT B-O
+MUAC PROPN B-AC
+, PUNCT B-O
+mid ADJ B-LF
+- PUNCT I-LF
+upper ADJ I-LF
+arm NOUN I-LF
+circumference NOUN I-LF
+; PUNCT B-O
+SAM PROPN B-AC
+, PUNCT B-O
+severe ADJ B-O
+AM PROPN B-AC
+; PUNCT B-O
+SQ PROPN B-AC
+, PUNCT B-O
+small ADJ B-O
+- PUNCT B-O
+quantity NOUN B-O
+lipid NOUN B-O
+- PUNCT B-O
+based VERB B-O
+nutrition NOUN B-O
+supplement NOUN B-O
+; PUNCT B-O
+-LNSWLZ PROPN B-AC
+, PUNCT B-O
+weight NOUN B-LF
+- PUNCT I-LF
+for ADP I-LF
+- PUNCT I-LF
+length NOUN I-LF
+z NOUN I-LF
+- PUNCT I-LF
+score NOUN I-LF
+A DET B-O
+candidate NOUN B-O
+target NOUN B-O
+pathway NOUN B-O
+is AUX B-O
+quorum NOUN B-LF
+sensing NOUN I-LF
+( PUNCT B-O
+QS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+many ADJ B-O
+bacterial ADJ B-O
+pathogens NOUN B-O
+use VERB B-O
+to PART B-O
+coordinately ADV B-O
+regulate VERB B-O
+virulence NOUN B-O
+determinants NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+order NOUN B-O
+to PART B-O
+understand VERB B-O
+how SCONJ B-O
+p84 NOUN B-O
+could AUX B-O
+mask VERB B-O
+Ser582 NOUN B-O
+phosphorylation NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+to PART B-O
+map VERB B-O
+the DET B-O
+p110γ NOUN B-O
+- PUNCT B-O
+p84 NOUN B-O
+contact NOUN B-O
+interface NOUN B-O
+, PUNCT B-O
+hydrogen NOUN B-LF
+deuterium NOUN I-LF
+exchange NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT B-O
+HDX-MS PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+used VERB B-O
+. PUNCT B-O
+
+In ADP B-O
+more ADJ B-O
+than ADP B-O
+400 NUM B-O
+studies NOUN B-O
+compiled VERB B-O
+in ADP B-O
+the DET B-O
+GWAS PROPN B-AC
+catalog NOUN B-O
+[ PUNCT B-O
+108 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+only ADV B-O
+a DET B-O
+small ADJ B-O
+minority NOUN B-O
+of ADP B-O
+the DET B-O
+trait NOUN B-LF
+/ SYM I-LF
+disease NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+SNPs NOUN I-LF
+( PUNCT B-O
+TASs PROPN B-AC
+) NOUN B-O
+occur VERB B-O
+in ADP B-O
+protein NOUN B-O
+- PUNCT B-O
+coding VERB B-O
+regions NOUN B-O
+; PUNCT B-O
+the DET B-O
+large ADJ B-O
+majority NOUN B-O
+( PUNCT B-O
+89 NUM B-O
+% NOUN B-O
+) NOUN B-O
+are AUX B-O
+in ADP B-O
+noncoding ADJ B-O
+regions NOUN B-O
+. PUNCT B-O
+
+Statistical ADJ B-O
+comparisons NOUN B-O
+were AUX B-O
+performed VERB B-O
+with ADP B-O
+a DET B-O
+2 NUM B-O
+- PUNCT B-O
+way NOUN B-O
+ANOVA NOUN B-O
+using VERB B-O
+time NOUN B-O
+and CCONJ B-O
+genotype NOUN B-O
+as ADP B-O
+factors NOUN B-O
+, PUNCT B-O
+followed VERB B-O
+by ADP B-O
+post ADJ B-O
+hoc ADJ B-O
+pairwise ADJ B-O
+comparisons NOUN B-O
+at ADP B-O
+each DET B-O
+time NOUN B-O
+point NOUN B-O
+to ADP B-O
+obtain VERB B-O
+nominal ADJ B-O
+p NOUN B-O
+- PUNCT B-O
+values NOUN B-O
+, PUNCT B-O
+which PRON B-O
+were AUX B-O
+subjected VERB B-O
+to ADP B-O
+a DET B-O
+Tukey PROPN B-O
+correction NOUN B-O
+for ADP B-O
+multiple ADJ B-O
+comparisons NOUN B-O
+( PUNCT B-O
+S1 PROPN B-O
+Data PROPN B-O
+, PUNCT B-O
+Sheet PROPN B-O
+1 NUM B-O
+G PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+AMPK PROPN B-AC
+, PUNCT B-O
+adenosine NOUN B-LF
+monophosphate NOUN I-LF
+regulated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+; PUNCT B-O
+DTS PROPN B-AC
+, PUNCT B-O
+developmentally ADV B-LF
+timed VERB I-LF
+sleep NOUN I-LF
+; PUNCT B-O
+L1 PROPN B-AC
+stage NOUN B-O
+, PUNCT B-O
+first ADJ B-LF
+larval ADJ I-LF
+stage NOUN I-LF
+; PUNCT B-O
+ns PROPN B-AC
+, PUNCT B-O
+not PART B-LF
+significant ADJ I-LF
+; PUNCT B-O
+p PROPN B-AC
+-AMPK PROPN B-AC
+, PUNCT B-O
+phosphorylated VERB B-LF
+AMPK NOUN I-LF
+AMPK PROPN B-AC
+; PUNCT B-O
+SIS PROPN B-AC
+, PUNCT B-O
+stress NOUN B-LF
+- PUNCT I-LF
+induced VERB I-LF
+sleep NOUN I-LF
+; PUNCT B-O
+UVC PROPN B-AC
+, PUNCT B-O
+ultraviolet ADJ B-LF
+C NOUN I-LF
+; PUNCT B-O
+WT PROPN B-O
+, PUNCT B-O
+wild ADJ B-O
+type NOUN B-O
+. PUNCT B-O
+
+Logistic ADJ B-O
+regression NOUN B-O
+analysis NOUN B-O
+showed VERB B-O
+that SCONJ B-O
+the DET B-O
+independent ADJ B-O
+factors NOUN B-O
+associated VERB B-O
+with ADP B-O
+mortality NOUN B-O
+were AUX B-O
+postoperative ADJ B-O
+lactate ADJ B-O
+level NOUN B-O
+( PUNCT B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+[ X B-O
+OR PROPN B-AC
+] X B-O
+1.926 NUM B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X B-O
+CI PROPN B-AC
+] X B-O
+1.101–3.089 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.007 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+postoperative ADJ B-O
+sequential ADJ B-O
+organ NOUN B-O
+failure NOUN B-O
+assessment NOUN B-O
+score NOUN B-O
+( PUNCT B-O
+OR PROPN B-AC
+1.593 NUM B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+1.160–2.187 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.004 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+DNI PROPN B-AC
+on ADP B-O
+POD1 PROPN B-O
+( PUNCT B-O
+OR PROPN B-AC
+1.118 NUM B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+1.028–1.215 NUM B-O
+, PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.009 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Missing VERB B-O
+values NOUN B-O
+in ADP B-O
+NSDUH PROPN B-AC
+are AUX B-O
+imputed VERB B-O
+by ADP B-O
+SAMHSA PROPN B-AC
+prior ADV B-O
+to ADP B-O
+release NOUN B-O
+of ADP B-O
+the DET B-O
+dataset NOUN B-O
+using VERB B-O
+a DET B-O
+predictive ADJ B-LF
+mean ADJ I-LF
+neighborhood NOUN I-LF
+( PUNCT B-O
+PMN PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+a DET B-O
+modified VERB B-O
+PMN PROPN B-AC
+as SCONJ B-O
+detailed VERB B-O
+in ADP B-O
+the DET B-O
+NSDUH PROPN B-AC
+codebook NOUN B-O
+[ PUNCT B-O
+26 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Mutation NOUN B-O
+of ADP B-O
+serine NOUN B-LF
+( PUNCT B-O
+S PROPN B-AC
+) PUNCT B-O
+424 NUM B-O
+to ADP B-O
+alanine NOUN B-LF
+( PUNCT B-O
+A PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+mimics NOUN B-O
+dephosphorylation NOUN B-O
+) PUNCT B-O
+inhibits VERB B-O
+HDAC3 PROPN B-AC
+enzyme NOUN B-O
+activity NOUN B-O
+without ADP B-O
+affecting VERB B-O
+its PRON B-O
+expression NOUN B-O
+or CCONJ B-O
+subcellular ADJ B-O
+localization NOUN B-O
+[ PUNCT B-O
+38 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+data NOUN B-O
+from ADP B-O
+the DET B-O
+fatty ADJ B-O
+acid NOUN B-O
+compositions NOUN B-O
+were AUX B-O
+used VERB B-O
+to ADP B-O
+investigate VERB B-O
+the DET B-O
+nutritional ADJ B-O
+lipid NOUN B-O
+quality NOUN B-O
+indices NOUN B-O
+from ADP B-O
+the DET B-O
+five NUM B-O
+evaluated VERB B-O
+freshwater NOUN B-O
+fish NOUN B-O
+species NOUN B-O
+through ADP B-O
+three NUM B-O
+important ADJ B-O
+indicators NOUN B-O
+, PUNCT B-O
+namely ADV B-O
+, PUNCT B-O
+index NOUN B-LF
+of ADP I-LF
+atherogenicity NOUN I-LF
+( PUNCT B-O
+IA PROPN B-AC
+) X B-O
+and CCONJ B-O
+index NOUN B-LF
+of ADP I-LF
+thrombogenicity NOUN I-LF
+( PUNCT B-O
+IT PROPN B-AC
+) X B-O
+, PUNCT B-O
+according VERB B-O
+to ADP B-O
+Ulbricht PROPN B-O
+and CCONJ B-O
+Southgate PROPN B-O
+[ X B-O
+37 NUM B-O
+] PUNCT B-O
+with ADP B-O
+modifications NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+hypocholesterolemic ADJ B-LF
+/ SYM I-LF
+hypercholesterolemic ADJ I-LF
+ratio NOUN I-LF
+( PUNCT B-O
+h PROPN B-AC
+) X B-O
+according VERB B-O
+to ADP B-O
+Santos PROPN B-O
+- PUNCT B-O
+Silva PROPN B-O
+, PUNCT B-O
+Bessa PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+Santos PROPN B-O
+- PUNCT B-O
+Silva PROPN B-O
+[ X B-O
+38 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+as SCONJ B-O
+follows VERB B-O
+: PUNCT B-O
+/HIA=(4×C14:0+C16:0)/(∑MUFA+∑(n–6)+∑(n–3))IT=(C14:0+C16:0+C18:0)/(0.5×∑MUFA+0.5×∑(n–6)+3×∑(n–3)+100×∑(n–3)/∑(n–6))h PROPN B-AC
++ X B-O
+16:0 NUM B-O
+) X B-O
+A DET B-O
+retrospective ADJ B-O
+cross ADJ B-O
+- ADJ B-O
+sectional ADJ B-O
+study NOUN B-O
+was AUX B-O
+conducted VERB B-O
+on ADP B-O
+medical ADJ B-O
+records NOUN B-O
+of ADP B-O
+patients NOUN B-O
+admitted VERB B-O
+from ADP B-O
+August PROPN B-O
+1 NUM B-O
+, PUNCT B-O
+2013‒July NUM B-O
+31 NUM B-O
+, PUNCT B-O
+2018 NUM B-O
+in ADP B-O
+Ayder PROPN B-LF
+Comprehensive PROPN I-LF
+Specialized PROPN I-LF
+Hospital PROPN I-LF
+( PUNCT B-O
+ACSH PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+found VERB B-O
+in ADP B-O
+Mekelle PROPN B-O
+, PUNCT B-O
+the DET B-O
+capital NOUN B-O
+city NOUN B-O
+of ADP B-O
+Tigray PROPN B-O
+regional ADJ B-O
+state NOUN B-O
+, PUNCT B-O
+783 NUM B-O
+Kilometers NOUN B-O
+away ADV B-O
+from ADP B-O
+Addis PROPN B-O
+Ababa PROPN B-O
+, PUNCT B-O
+Ethiopia PROPN B-O
+. PUNCT B-O
+
+U2OS PROPN B-O
+reporter NOUN B-O
+cell NOUN B-O
+lines NOUN B-O
+specifically ADV B-O
+designed VERB B-O
+to PART B-O
+repair NOUN B-O
+DNA NOUN B-O
+damage NOUN B-O
+through ADP B-O
+nonhomologous ADJ B-LF
+end NOUN I-LF
+joining NOUN I-LF
+( PUNCT B-O
+NHEJ PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+homology NOUN B-LF
+- PUNCT I-LF
+directed VERB I-LF
+repair NOUN I-LF
+( PUNCT B-O
+HDR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+were AUX B-O
+transfected VERB B-O
+with ADP B-O
+nonspecific ADJ B-O
+control NOUN B-O
+( PUNCT B-O
+si PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+-NCSam68 PROPN B-AC
+- PUNCT B-O
+specific ADJ B-O
+( PUNCT B-O
+si NOUN B-O
+- PUNCT B-O
+Sam68 PROPN B-AC
+) PUNCT B-O
+small ADJ B-O
+interference NOUN B-O
+RNA NOUN B-O
+, PUNCT B-O
+together ADV B-O
+with ADP B-O
+( PUNCT B-O
++ PUNCT B-O
+) PUNCT B-O
+or CCONJ B-O
+without ADP B-O
+( PUNCT B-O
+− PUNCT B-O
+) PUNCT B-O
+I NOUN B-O
+- PUNCT B-O
+SceI PROPN B-O
+plasmid NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+GFP PROPN B-AC
+) PUNCT B-O
+control NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+carboxysome NOUN B-O
+is AUX B-O
+a DET B-O
+bacterial ADJ B-O
+organelle NOUN B-O
+that PRON B-O
+functions VERB B-O
+to PART B-O
+enhance VERB B-O
+the DET B-O
+efficiency NOUN B-O
+of ADP B-O
+CO2 NOUN B-O
+fixation NOUN B-O
+by ADP B-O
+encapsulating VERB B-O
+the DET B-O
+enzymes NOUN B-O
+ribulose NOUN B-LF
+bisphosphate NOUN I-LF
+carboxylase NOUN I-LF
+/ SYM I-LF
+oxygenase NOUN I-LF
+( PUNCT B-O
+RuBisCO PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+carbonic ADJ B-O
+anhydrase NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+following ADJ B-O
+ELISA PROPN B-O
+kits NOUN B-O
+were AUX B-O
+used VERB B-O
+: PUNCT B-O
+LRG1 PROPN B-AC
+ELISA PROPN B-O
+kit NOUN B-O
+( PUNCT B-O
+Cosmic PROPN B-O
+Corporation PROPN B-O
+, PUNCT B-O
+Tokyo PROPN B-O
+, PUNCT B-O
+Japan PROPN B-O
+, PUNCT B-O
+product NOUN B-O
+number NOUN B-O
+; PUNCT B-O
+T131C100 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+Human PROPN B-O
+Total PROPN B-O
+Angiotensinogen PROPN B-LF
+( PUNCT B-O
+AGT PROPN B-AC
+) PUNCT B-O
+Assay PROPN B-O
+Kit PROPN B-O
+( PUNCT B-O
+Immuno PROPN B-O
+- PUNCT B-O
+Biological PROPN B-O
+Laboratories PROPN B-O
+, PUNCT B-O
+Gunma PROPN B-O
+, PUNCT B-O
+Japan PROPN B-O
+, PUNCT B-O
+product NOUN B-O
+number NOUN B-O
+; PUNCT B-O
+27412 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+prospectively ADV B-O
+collected VERB B-O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT B-O
+PBMCs PROPN B-AC
+) PUNCT B-O
+by ADP B-O
+leukapheresis NOUN B-O
+from ADP B-O
+a DET B-O
+55 NUM B-O
+- PUNCT B-O
+year NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+man NOUN B-O
+with ADP B-O
+chronic ADJ B-O
+HIV PROPN B-O
+infection NOUN B-O
+before ADP B-O
+and CCONJ B-O
+after ADP B-O
+allo-SCT PROPN B-AC
+to PART B-O
+measure VERB B-O
+the DET B-O
+size NOUN B-O
+of ADP B-O
+the DET B-O
+HIV-1 PROPN B-O
+reservoir NOUN B-O
+and CCONJ B-O
+characterize VERB B-O
+viral ADJ B-O
+phylogeny NOUN B-O
+and CCONJ B-O
+phenotypic ADJ B-O
+changes NOUN B-O
+in ADP B-O
+immune ADJ B-O
+cells NOUN B-O
+. PUNCT B-O
+
+Outcome NOUN B-O
+measures NOUN B-O
+were AUX B-O
+deaths NOUN B-O
+, PUNCT B-O
+along ADP B-O
+with ADP B-O
+nonfatal ADJ B-O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+( PUNCT B-O
+MI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+stroke NOUN B-O
+, PUNCT B-O
+congestive ADJ B-LF
+heart NOUN I-LF
+failure NOUN I-LF
+( PUNCT B-O
+CHF PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+transient ADJ B-LF
+ischemic ADJ I-LF
+attack NOUN I-LF
+( PUNCT B-O
+TIA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+antihypertensive ADJ B-O
+treatment NOUN B-O
+recorded VERB B-O
+from ADP B-O
+structured VERB B-O
+interviews NOUN B-O
+at ADP B-O
+scheduled VERB B-O
+intervals NOUN B-O
+. PUNCT B-O
+
+At ADP B-O
+GW PROPN B-O
+15–26 NUM B-O
+, PUNCT B-O
+a DET B-O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT B-O
+SD PROPN B-AC
+) PUNCT B-O
+increase NOUN B-O
+in ADP B-O
+total ADJ B-O
+n-3 NOUN B-O
+PUFAs PROPN B-AC
+and CCONJ B-O
+individual ADJ B-O
+n-3 NOUN B-O
+DPA PROPN B-AC
+was AUX B-O
+associated VERB B-O
+with ADP B-O
+a DET B-O
+36 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+adjusted VERB B-O
+odds NOUN B-O
+ratio NOUN B-O
+0.64 NUM B-O
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI NOUN B-O
+0.42–0.96 NUM B-O
+; PUNCT B-O
+P NOUN B-O
+= SYM B-O
+0.042 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+33 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+0.67 NUM B-O
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI NOUN B-O
+0.45–0.99 NUM B-O
+; PUNCT B-O
+P NOUN B-O
+= SYM B-O
+0.047 NUM B-O
+) PUNCT B-O
+lower ADJ B-O
+risk NOUN B-O
+of ADP B-O
+GDM PROPN B-AC
+, PUNCT B-O
+respectively ADV B-O
+; PUNCT B-O
+however ADV B-O
+, PUNCT B-O
+the DET B-O
+significance NOUN B-O
+did AUX B-O
+not PART B-O
+persist VERB B-O
+after ADP B-O
+post X B-O
+hoc X B-O
+false ADJ B-O
+- PUNCT B-O
+discovery NOUN B-O
+rate NOUN B-O
+( PUNCT B-O
+FDR PROPN B-AC
+) PUNCT B-O
+correction NOUN B-O
+( PUNCT B-O
+FDR PROPN B-AC
+- PUNCT B-O
+corrected VERB B-O
+P NOUN B-O
+values NOUN B-O
+> SYM B-O
+0.05 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Terminal ADJ B-O
+hypertrophic ADJ B-O
+differentiation NOUN B-O
+is AUX B-O
+accompanied VERB B-O
+by ADP B-O
+a DET B-O
+massive ADJ B-O
+increase NOUN B-O
+in ADP B-O
+cell NOUN B-O
+volume NOUN B-O
+and CCONJ B-O
+expression NOUN B-O
+of ADP B-O
+alkaline ADJ B-LF
+phosphatase NOUN I-LF
+( PUNCT B-O
+ALP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+an DET B-O
+enzyme NOUN B-O
+required VERB B-O
+for ADP B-O
+mineralization NOUN B-O
+of ADP B-O
+cartilage NOUN B-O
+[ PUNCT B-O
+20 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+the DET B-O
+first ADJ B-O
+step NOUN B-O
+in ADP B-O
+cartilage NOUN B-O
+remodeling NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+next ADV B-O
+asked VERB B-O
+whether SCONJ B-O
+the DET B-O
+surface NOUN B-O
+polarization NOUN B-O
+of ADP B-O
+other ADJ B-O
+axonal ADJ B-O
+membrane NOUN B-O
+proteins NOUN B-O
+was AUX B-O
+affected VERB B-O
+in ADP B-O
+the DET B-O
+absence NOUN B-O
+of ADP B-O
+SorCS1 PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+cell NOUN B-O
+adhesion NOUN B-O
+molecules NOUN B-O
+neuron NOUN B-LF
+- PUNCT I-LF
+glia NOUN I-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+L1 NOUN I-LF
+( PUNCT B-O
+L1/NgCAM PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+contactin NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+2 NUM I-LF
+( PUNCT B-O
+Caspr2 PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+both PRON B-O
+targeted VERB B-O
+to ADP B-O
+the DET B-O
+axonal ADJ B-O
+surface NOUN B-O
+but CCONJ B-O
+via ADP B-O
+distinct ADJ B-O
+trafficking NOUN B-O
+routes NOUN B-O
+. PUNCT B-O
+
+These DET B-O
+CRMs PROPN B-AC
+act VERB B-O
+as ADP B-O
+neurogenic ADJ B-LF
+ectoderm NOUN I-LF
+enhancers NOUN I-LF
+( PUNCT B-O
+NEEs PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+function VERB B-O
+to PART B-O
+drive VERB B-O
+gene NOUN B-O
+expression NOUN B-O
+in ADP B-O
+the DET B-O
+early ADJ B-O
+embryonic ADJ B-O
+neuroectoderm NOUN B-O
+before SCONJ B-O
+gastrulation NOUN B-O
+has AUX B-O
+commenced VERB B-O
+[ PUNCT B-O
+36 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+autoxidation NOUN B-O
+of ADP B-O
+intracellular ADJ B-O
+oxyHb NOUN B-O
+and CCONJ B-O
+downstream ADJ B-O
+free ADJ B-O
+radical NOUN B-O
+formation NOUN B-O
+is AUX B-O
+prevented VERB B-O
+mainly ADV B-O
+by ADP B-O
+superoxide NOUN B-LF
+dismutase NOUN I-LF
+( PUNCT B-O
+SOD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+catalase NOUN B-O
+and CCONJ B-O
+glutathione NOUN B-LF
+peroxidase NOUN I-LF
+( PUNCT B-O
+GPx PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+18,19 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+paper NOUN B-O
+examines VERB B-O
+whether SCONJ B-O
+practices NOUN B-O
+regarding VERB B-O
+consent NOUN B-O
+, PUNCT B-O
+confidentiality NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+referral NOUN B-O
+vary VERB B-O
+depending VERB B-O
+on ADP B-O
+whether SCONJ B-O
+testing NOUN B-O
+is AUX B-O
+provided VERB B-O
+through ADP B-O
+voluntary ADJ B-LF
+counseling NOUN I-LF
+and CCONJ I-LF
+testing NOUN I-LF
+( PUNCT B-O
+VCT PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+provider NOUN B-O
+- PUNCT B-O
+initiated VERB B-O
+testing NOUN B-O
+. PUNCT B-O
+
+Mice NOUN B-O
+that PRON B-O
+need VERB B-O
+to ADP B-O
+be AUX B-O
+perfused VERB B-O
+with ADP B-O
+PBS PROPN B-AC
+and/or CCONJ B-O
+4 NUM B-O
+% NOUN B-O
+paraformaldehyde NOUN B-LF
+( PUNCT B-O
+PFA PROPN B-AC
+) PUNCT B-O
+prior ADV B-O
+to ADP B-O
+tissue NOUN B-O
+harvest NOUN B-O
+were AUX B-O
+anesthetized VERB B-O
+with ADP B-O
+a DET B-O
+combination NOUN B-O
+of ADP B-O
+ketamine NOUN B-O
+( PUNCT B-O
+20 NUM B-O
+mg NOUN B-O
+/ SYM B-O
+kg NOUN B-O
+body NOUN B-O
+weight NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+xylazine NOUN B-O
+( PUNCT B-O
+2 NUM B-O
+mg NOUN B-O
+/ SYM B-O
+kg NOUN B-O
+body NOUN B-O
+weight NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Mild ADJ B-LF
+cognitive ADJ I-LF
+impairment NOUN I-LF
+( PUNCT B-O
+MCI PROPN B-AC
+) PUNCT B-O
+refers VERB B-O
+to ADP B-O
+a DET B-O
+transitional ADJ B-O
+zone NOUN B-O
+between ADP B-O
+normal ADJ B-O
+ageing NOUN B-O
+and CCONJ B-O
+dementia NOUN B-O
+. PUNCT B-O
+
+Quantitative ADJ B-O
+data NOUN B-O
+were AUX B-O
+to ADP B-O
+analyze VERB B-O
+completeness NOUN B-O
+and CCONJ B-O
+timeliness NOUN B-O
+of ADP B-O
+surveillance NOUN B-O
+system NOUN B-O
+performance NOUN B-O
+from ADP B-O
+national ADJ B-O
+District PROPN B-LF
+Health PROPN I-LF
+Information PROPN I-LF
+System PROPN I-LF
+2 NUM I-LF
+( PUNCT B-O
+DHIS2 PROPN B-AC
+) PUNCT B-O
+during ADP B-O
+October PROPN B-O
+2014 NUM B-O
+to ADP B-O
+September PROPN B-O
+2016 NUM B-O
+. PUNCT B-O
+
+Importantly ADV B-O
+, PUNCT B-O
+the DET B-O
+mice NOUN B-O
+are AUX B-O
+resistant ADJ B-O
+to ADP B-O
+the DET B-O
+autoimmune ADJ B-O
+disease NOUN B-O
+models NOUN B-O
+collagen NOUN B-O
+- PUNCT B-O
+induced VERB B-O
+arthritis NOUN B-O
+and CCONJ B-O
+experimental ADJ B-LF
+autoimmune ADJ I-LF
+encephalomyelitis NOUN I-LF
+( PUNCT B-O
+EAE PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+20 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+have VERB B-O
+less ADV B-O
+aggressive ADJ B-O
+Kras PROPN B-O
+- PUNCT B-O
+induced VERB B-O
+inflammatory ADJ B-O
+pancreatic ADJ B-O
+cancer NOUN B-O
+[ PUNCT B-O
+21 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+fail VERB B-O
+to ADP B-O
+mount VERB B-O
+an DET B-O
+effective ADJ B-O
+IL-17A PROPN B-AC
+- PUNCT B-O
+dependent ADJ B-O
+immune ADJ B-O
+response NOUN B-O
+to ADP B-O
+Citrobacter PROPN B-O
+rodentium NOUN B-O
+infection NOUN B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+surgically ADV B-O
+removed VERB B-O
+tissue NOUN B-O
+was AUX B-O
+cut VERB B-O
+to PART B-O
+smaller ADJ B-O
+pieces NOUN B-O
+with ADP B-O
+scissors NOUN B-O
+under ADP B-O
+sterile ADJ B-O
+conditions NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+then ADV B-O
+incubated VERB B-O
+for ADP B-O
+15 NUM B-O
+min NOUN B-O
+at ADP B-O
+room NOUN B-LF
+temperature NOUN I-LF
+( PUNCT B-O
+RT PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+dithiothreitol PROPN B-O
+: PUNCT B-O
+Hank´s PART B-O
+balanced ADJ B-O
+salt NOUN B-O
+solution NOUN B-O
+( PUNCT B-O
+HBSS PROPN B-O
+) PUNCT B-O
+( PUNCT B-O
+Biosera PROPN B-O
+, PUNCT B-O
+Nuaille PROPN B-O
+, PUNCT B-O
+France PROPN B-O
+) PUNCT B-O
+mix NOUN B-O
+( PUNCT B-O
+1:9 NUM B-O
+v NOUN B-O
+/ SYM B-O
+v NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+order NOUN B-O
+to PART B-O
+remove VERB B-O
+potential ADJ B-O
+contamination NOUN B-O
+. PUNCT B-O
+
+OR PROPN B-AC
+, PUNCT B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+ref NOUN B-O
+. PUNCT B-O
+
+, PUNCT B-O
+reference NOUN B-O
+; PUNCT B-O
+R1 NOUN B-O
+, PUNCT B-O
+positive ADJ B-O
+; PUNCT B-O
+R0 NOUN B-O
+, PUNCT B-O
+negative ADJ B-O
+resection NOUN B-O
+margins NOUN B-O
+Malondialdehyde NOUN B-LF
+acetaldehyde NOUN I-LF
+- PUNCT B-O
+modified VERB B-O
+LDL PROPN B-AC
+( PUNCT B-O
+MAA PROPN B-AC
+- PUNCT B-O
+LDL PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+copper NOUN B-O
+- PUNCT B-O
+oxidized VERB B-O
+LDL PROPN B-AC
+( PUNCT B-O
+CuOx-LDL PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+prepared VERB B-O
+as SCONJ B-O
+described VERB B-O
+[ PUNCT B-O
+21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Then ADV B-O
+, PUNCT B-O
+the DET B-O
+specimens NOUN B-O
+were AUX B-O
+washed VERB B-O
+twice ADV B-O
+with ADP B-O
+stain NOUN B-O
+buffer NOUN B-O
+and CCONJ B-O
+subsequently ADV B-O
+mounted VERB B-O
+with ADP B-O
+fluoroGel PROPN B-O
+mounting NOUN B-O
+medium NOUN B-O
+( PUNCT B-O
+GeneTex PROPN B-O
+, PUNCT B-O
+Inc PROPN B-O
+, PUNCT B-O
+Irvine PROPN B-O
+, PUNCT B-O
+CA PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Stained VERB B-O
+specimens NOUN B-O
+were AUX B-O
+examined VERB B-O
+and CCONJ B-O
+captured VERB B-O
+with ADP B-O
+Leica PROPN B-O
+TCS PROPN B-O
+SPII PROPN B-O
+confocal ADJ B-LF
+laser NOUN I-LF
+scanning VERB I-LF
+microscopy NOUN I-LF
+system NOUN B-O
+( PUNCT B-O
+CLSM PROPN B-AC
+, PUNCT B-O
+; PUNCT B-O
+Leica PROPN B-O
+Microsystem PROPN B-O
+, PUNCT B-O
+GmbH PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+with ADP B-O
+LAS PROPN B-O
+AF PROPN B-O
+Lite PROPN B-O
+software NOUN B-O
+( PUNCT B-O
+Leica PROPN B-O
+Microsystems PROPN B-O
+, PUNCT B-O
+Mannheim PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+HEK PROPN B-AC
+, PUNCT B-O
+human ADJ B-LF
+embryonic ADJ I-LF
+kidney NOUN I-LF
+cell NOUN I-LF
+; PUNCT B-O
+ns PROPN B-O
+, PUNCT B-O
+not PART B-O
+significant ADJ B-O
+; PUNCT B-O
+WT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+type NOUN I-LF
+. PUNCT B-O
+
+Malondialdehyde NOUN B-LF
+( PUNCT B-O
+MDA PROPN B-AC
+) PUNCT B-O
+content NOUN B-O
+was AUX B-O
+measured VERB B-O
+by ADP B-O
+the DET B-O
+procedures NOUN B-O
+described VERB B-O
+by ADP B-O
+Wang PROPN B-O
+et PROPN B-O
+al NOUN B-O
+. PUNCT B-O
+
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Ischaemia NOUN B-O
+- PUNCT B-O
+reperfusion NOUN B-O
+injury NOUN B-O
+in ADP B-O
+kidney NOUN B-O
+transplantation NOUN B-O
+leads VERB B-O
+to ADP B-O
+delayed VERB B-LF
+graft NOUN I-LF
+function NOUN I-LF
+( PUNCT B-O
+DGF PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+associated VERB B-O
+with ADP B-O
+reduced VERB B-O
+long ADJ B-O
+term NOUN B-O
+graft NOUN B-O
+function NOUN B-O
+. PUNCT B-O
+
+Opaque NOUN B-O
+a DET B-O
+and CCONJ B-O
+α PUNCT B-O
+cells NOUN B-O
+secrete VERB B-O
+a DET B-O
+sex NOUN B-O
+- PUNCT B-O
+specific ADJ B-O
+pheromone NOUN B-O
+and CCONJ B-O
+induce VERB B-O
+the DET B-O
+formation NOUN B-O
+of ADP B-O
+mating NOUN B-O
+projections NOUN B-O
+in ADP B-O
+cells NOUN B-O
+with ADP B-O
+an DET B-O
+opposite ADJ B-O
+Mating NOUN B-LF
+type NOUN I-LF
+locus NOUN I-LF
+( PUNCT B-O
+MTL PROPN B-AC
+) PUNCT B-O
+type NOUN B-O
+, PUNCT B-O
+thus ADV B-O
+initiating VERB B-O
+cell NOUN B-O
+fusion NOUN B-O
+and CCONJ B-O
+mating NOUN B-O
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT B-O
+HR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+velocity NOUN B-O
+, PUNCT B-O
+left ADJ B-LF
+ventricle NOUN I-LF
+( PUNCT B-O
+LV PROPN B-AC
+) PUNCT B-O
+mass NOUN B-O
+, PUNCT B-O
+LV PROPN B-LF
+internal ADJ I-LF
+LV PROPN B-AC
+diameter NOUN I-LF
+at ADP I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastole NOUN I-LF
+( PUNCT B-O
+LVID PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+LV PROPN B-LF
+posterior ADJ I-LF
+,dLV PROPN B-AC
+wall NOUN I-LF
+thickness NOUN I-LF
+at ADP I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastole NOUN I-LF
+( PUNCT B-O
+LVPW PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+LV PROPN B-LF
+anterior ADJ I-LF
+,dLV PROPN B-AC
+wall NOUN I-LF
+thickness NOUN I-LF
+at ADP I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastole NOUN I-LF
+( PUNCT B-O
+LVAW PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+ejection NOUN B-LF
+fraction NOUN I-LF
+( PUNCT B-O
+,dEF PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+fractional ADJ B-LF
+shortening NOUN I-LF
+( PUNCT B-O
+FS PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+the DET B-O
+LV PROPN B-AC
+were AUX B-O
+measured VERB B-O
+. PUNCT B-O
+
+The DET B-O
+generation NOUN B-O
+of ADP B-O
+type NOUN B-LF
+2 NUM I-LF
+( PUNCT B-O
+Th2 PROPN B-AC
+) PUNCT B-O
+cytokines NOUN B-O
+, PUNCT B-O
+particularly ADV B-O
+interleukins NOUN B-LF
+( PUNCT B-O
+IL)-13 PROPN B-AC
+and CCONJ B-O
+IL-4 PROPN B-AC
+, PUNCT B-O
+is AUX B-O
+associated VERB B-O
+with ADP B-O
+parasite NOUN B-O
+expulsion NOUN B-O
+through ADP B-O
+increased VERB B-O
+epithelial ADJ B-O
+cell NOUN B-O
+turnover NOUN B-O
+, PUNCT B-O
+mucus NOUN B-O
+production NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+muscle NOUN B-O
+hypercontractility NOUN B-O
+[ PUNCT B-O
+28 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Photographs NOUN B-O
+showing VERB B-O
+double ADJ B-O
+- PUNCT B-O
+labeling NOUN B-O
+for ADP B-O
+galanin NOUN B-LF
+receptor NOUN I-LF
+type NOUN I-LF
+2 NUM I-LF
+( PUNCT B-O
+GalR2 PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+A PROPN B-O
+, PUNCT B-O
+D PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+NF200 PROPN B-O
+( PUNCT B-O
+B NOUN B-O
+, PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+merged VERB B-O
+images NOUN B-O
+( PUNCT B-O
+C PROPN B-O
+, PUNCT B-O
+F PROPN B-O
+) PUNCT B-O
+in ADP B-O
+dorsal ADJ B-LF
+root NOUN I-LF
+ganglion NOUN I-LF
+( PUNCT B-O
+DRG PROPN B-AC
+) PUNCT B-O
+neurons NOUN B-O
+of ADP B-O
+the DET B-O
+naïve ADJ B-O
+( PUNCT B-O
+A PROPN B-O
+- PUNCT B-O
+C PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+chronic ADJ B-O
+constriction NOUN B-O
+injury NOUN B-O
+1 NUM B-O
+week NOUN B-O
+( PUNCT B-O
+CCI1W PROPN B-O
+) PUNCT B-O
+( PUNCT B-O
+D PROPN B-O
+- PUNCT B-O
+F PROPN B-O
+) PUNCT B-O
+groups NOUN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+PRS PROPN B-AC
+, PUNCT B-O
+postreperfusion NOUN B-LF
+syndrome NOUN I-LF
+; PUNCT B-O
+PS PROPN B-O
+, PUNCT B-O
+propensity NOUN B-O
+score NOUN B-O
+. PUNCT B-O
+
+ABR PROPN B-AC
+, PUNCT B-O
+auditory ADJ B-LF
+brainstem NOUN I-LF
+response NOUN I-LF
+; PUNCT B-O
+DFNA PROPN B-O
+, PUNCT B-O
+non ADJ B-O
+- ADJ B-O
+syndromic ADJ B-O
+deafness NOUN B-O
+with ADP B-O
+dominant ADJ B-O
+inheritance NOUN B-O
+; PUNCT B-O
+DFNB PROPN B-O
+, PUNCT B-O
+non ADJ B-O
+- ADJ B-O
+syndromic ADJ B-O
+deafness NOUN B-O
+with ADP B-O
+recessive ADJ B-O
+inheritance NOUN B-O
+; PUNCT B-O
+DFNX PROPN B-O
+, PUNCT B-O
+non ADJ B-O
+- ADJ B-O
+syndromic ADJ B-O
+deafness NOUN B-O
+with ADP B-O
+X NOUN B-O
+- ADJ B-O
+linked VERB B-O
+inheritance NOUN B-O
+; PUNCT B-O
+Hemi PROPN B-O
+, PUNCT B-O
+hemizygote NOUN B-O
+; PUNCT B-O
+Het PROPN B-O
+, PUNCT B-O
+heterozygote NOUN B-O
+; PUNCT B-O
+Hom PROPN B-O
+, PUNCT B-O
+homozygote NOUN B-O
+; PUNCT B-O
+MGP PROPN B-AC
+, PUNCT B-O
+Mouse PROPN B-LF
+Genetics PROPN I-LF
+Project PROPN I-LF
+; PUNCT B-O
+tm PROPN B-AC
+, PUNCT B-O
+targeted VERB B-LF
+mutation NOUN I-LF
+. PUNCT B-O
+
+Phosphatidylcholine NOUN B-O
+( PUNCT B-O
+PC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+phosphatidic NOUN B-LF
+acid NOUN I-LF
+( PUNCT B-O
+PA PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+cholesterol NOUN B-O
+( PUNCT B-O
+CH NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Avanti PROPN B-O
+Polar PROPN B-O
+Lipids PROPN B-O
+, PUNCT B-O
+Alabaster PROPN B-O
+, PUNCT B-O
+AL PROPN B-O
+) PUNCT B-O
+were AUX B-O
+dissolved VERB B-O
+in ADP B-O
+chloroform NOUN B-O
+under ADP B-O
+argon NOUN B-O
+, PUNCT B-O
+mixed VERB B-O
+in ADP B-O
+3:1:1 NUM B-O
+proportion NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+( PUNCT B-O
+w NOUN B-O
+/ SYM B-O
+w NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+chloroform NOUN B-O
+was AUX B-O
+evaporated VERB B-O
+. PUNCT B-O
+
+Prior ADV B-O
+to ADP B-O
+data NOUN B-O
+collection NOUN B-O
+, PUNCT B-O
+a DET B-O
+two NUM B-O
+- NOUN B-O
+day NOUN B-O
+intensive ADJ B-O
+training NOUN B-O
+was AUX B-O
+given VERB B-O
+to ADP B-O
+data NOUN B-O
+collectors NOUN B-O
+( PUNCT B-O
+physiotherapist NOUN B-O
+) PUNCT B-O
+by ADP B-O
+the DET B-O
+principal ADJ B-O
+investigator NOUN B-O
+( PUNCT B-O
+KS PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+clinical ADJ B-O
+neurologist NOUN B-O
+of ADP B-O
+UOGH PROPN B-O
+following VERB B-O
+which PRON B-O
+a DET B-O
+pre NOUN B-O
+- NOUN B-O
+test NOUN B-O
+of ADP B-O
+data NOUN B-O
+collection NOUN B-O
+was AUX B-O
+carried VERB B-O
+out ADP B-O
+with ADP B-O
+15 NUM B-O
+PLHIV PROPN B-AC
+. PUNCT B-O
+
+Brief ADJ B-O
+peripheral ADJ B-O
+neuropathy NOUN B-O
+screening NOUN B-O
+tool NOUN B-O
+validated VERB B-O
+by ADP B-O
+the DET B-O
+AIDS PROPN B-LF
+Clinical PROPN I-LF
+trial PROPN I-LF
+Group PROPN I-LF
+( PUNCT B-O
+ACTG PROPN B-AC
+) PUNCT B-O
+[ X B-O
+20 X B-O
+] X B-O
+was AUX B-O
+administered VERB B-O
+by ADP B-O
+a DET B-O
+trained VERB B-O
+physiotherapist NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+objective NOUN B-O
+of ADP B-O
+this DET B-O
+study NOUN B-O
+was AUX B-O
+to ADP B-O
+assess VERB B-O
+whether SCONJ B-O
+SAM PROPN B-AC
+treatment NOUN B-O
+delivered VERB B-O
+by ADP B-O
+CHWs PROPN B-AC
+close ADJ B-O
+to ADP B-O
+families NOUN B-O
+’ PUNCT B-O
+locations NOUN B-O
+may AUX B-O
+improve VERB B-O
+the DET B-O
+early ADJ B-O
+identification NOUN B-O
+of ADP B-O
+cases NOUN B-O
+compared VERB B-O
+to ADP B-O
+outpatient NOUN B-O
+treatment NOUN B-O
+at ADP B-O
+health NOUN B-LF
+facilities NOUN I-LF
+( PUNCT B-O
+HFs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+a DET B-O
+decreased VERB B-O
+number NOUN B-O
+complicated ADJ B-O
+cases NOUN B-O
+referred VERB B-O
+to ADP B-O
+stabilization NOUN B-O
+centers NOUN B-O
+, PUNCT B-O
+increased VERB B-O
+anthropometric ADJ B-O
+measurements NOUN B-O
+at ADP B-O
+admission NOUN B-O
+( PUNCT B-O
+closer ADJ B-O
+to ADP B-O
+the DET B-O
+admission NOUN B-O
+threshold NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+similarity NOUN B-O
+in ADP B-O
+clinical ADJ B-O
+outcomes NOUN B-O
+( PUNCT B-O
+cure NOUN B-O
+, PUNCT B-O
+death NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+default NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Patients NOUN B-O
+are AUX B-O
+triaged VERB B-O
+to ADP B-O
+three NUM B-O
+sections NOUN B-O
+of ADP B-O
+the DET B-O
+ED PROPN B-AC
+( PUNCT B-O
+High ADJ B-O
+Acuity NOUN B-O
+, PUNCT B-O
+Low ADJ B-O
+Acuity NOUN B-O
+and CCONJ B-O
+Pediatrics NOUN B-O
+) PUNCT B-O
+based VERB B-O
+on ADP B-O
+the DET B-O
+Emergency PROPN B-LF
+Severity PROPN I-LF
+Index PROPN I-LF
+( PUNCT B-O
+ESI PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+age NOUN B-O
+. PUNCT B-O
+
+AP1 PROPN B-AC
+, PUNCT B-O
+activator NOUN B-LF
+protein NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+bHLH PROPN B-O
+, PUNCT B-O
+basic ADJ B-O
+helix NOUN B-O
+- PUNCT B-O
+loop NOUN B-O
+- PUNCT B-O
+helix NOUN B-O
+; PUNCT B-O
+ChIP PROPN B-AC
+, PUNCT B-O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+and CCONJ I-LF
+sequencing NOUN I-LF
+; PUNCT B-O
+-SeqdnIκBα PROPN B-AC
+, PUNCT B-O
+dominant ADJ B-O
+negative ADJ B-O
+NFKB PROPN B-O
+inhibitor NOUN B-O
+alpha NOUN B-O
+; PUNCT B-O
+FDR PROPN B-AC
+, PUNCT B-O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+; PUNCT B-O
+GO PROPN B-AC
+, PUNCT B-O
+Gene PROPN B-LF
+Ontology PROPN I-LF
+; PUNCT B-O
+NF PROPN B-AC
+, PUNCT B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+kappa NOUN I-LF
+B NOUN I-LF
+; PUNCT B-O
+PPARG PROPN B-O
+, PUNCT B-O
+peroxisome NOUN B-O
+proliferator NOUN B-O
+– PUNCT B-O
+activated VERB B-O
+receptor NOUN B-O
+gamma NOUN B-O
+; PUNCT B-O
+-κBRNA PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT B-O
+SOX8 PROPN B-O
+, PUNCT B-O
+SRY NOUN B-O
+- PUNCT B-O
+box NOUN B-O
+8 NUM B-O
+; PUNCT B-O
+-SeqTet PROPN B-AC
+, PUNCT B-O
+tetracycline NOUN B-LF
+. PUNCT B-O
+
+Antibodies NOUN B-O
+were AUX B-O
+used VERB B-O
+at ADP B-O
+dilutions NOUN B-O
+recommended VERB B-O
+by ADP B-O
+the DET B-O
+manufacturers NOUN B-O
+. PUNCT B-O
+
+1 NUM B-O
+- PUNCT B-O
+methyl-4 NOUN B-O
+- PUNCT B-O
+phenylpyridinium NOUN B-O
+( PUNCT B-O
+MPP+ NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+adenosine NOUN B-LF
+- PUNCT I-LF
+triphosphate NOUN I-LF
+( PUNCT B-O
+ATP PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+obtained VERB B-O
+from ADP B-O
+Sigma PROPN B-O
+- PUNCT B-O
+Aldrich PROPN B-O
+. PUNCT B-O
+
+Another DET B-O
+example NOUN B-O
+is AUX B-O
+the DET B-O
+World PROPN B-O
+Bank PROPN B-O
+and CCONJ B-O
+UNICEF PROPN B-O
+– PUNCT B-O
+funded VERB B-O
+Child PROPN B-LF
+Survival PROPN I-LF
+and CCONJ I-LF
+Safe PROPN I-LF
+Motherhood PROPN I-LF
+( PUNCT B-O
+CSSM PROPN B-AC
+) PUNCT B-O
+Program PROPN B-O
+, PUNCT B-O
+which PRON B-O
+was AUX B-O
+implemented VERB B-O
+from ADP B-O
+1992–93 NUM B-O
+to ADP B-O
+1997–98 NUM B-O
+and CCONJ B-O
+later ADV B-O
+merged VERB B-O
+into ADP B-O
+the DET B-O
+Reproductive PROPN B-LF
+and CCONJ I-LF
+Child PROPN I-LF
+Health PROPN I-LF
+( PUNCT B-O
+RCH PROPN B-AC
+) PUNCT B-O
+program NOUN B-O
+in ADP B-O
+1997–98 NUM B-O
+( PUNCT B-O
+http://mohfw.nic.in/dofw%20website/Child%20healthrti.pdf X B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Following VERB B-O
+24 NUM B-O
+h NOUN B-O
+to ADP B-O
+48h NUM B-O
+of ADP B-O
+transfection NOUN B-O
+( PUNCT B-O
+Lipofectamine PROPN B-O
+2000 NUM B-O
+, PUNCT B-O
+Invitrogen PROPN B-O
+) PUNCT B-O
+of ADP B-O
+3μg ADP B-O
+of ADP B-O
+expression NOUN B-O
+plasmid(s NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+100 NUM B-O
+mm NOUN B-O
+diameter NOUN B-O
+plates NOUN B-O
+of ADP B-O
+HEK293 NOUN B-O
+T NOUN B-O
+cells NOUN B-O
+were AUX B-O
+washed VERB B-O
+in ADP B-O
+cold ADJ B-O
+PBS PROPN B-O
+, PUNCT B-O
+lysed VERB B-O
+in ADP B-O
+1ml NUM B-O
+of ADP B-O
+TX100 PROPN B-AC
+lysis NOUN B-O
+buffer NOUN B-O
+containing VERB B-O
+Tris PROPN B-O
+50mM PROPN B-O
+PH:7.5 NUM B-O
+, PUNCT B-O
+NaCl PROPN B-O
+150 NUM B-O
+mM NOUN B-O
+1 NUM B-O
+% NOUN B-O
+of ADP B-O
+Triton PROPN B-LF
+X100 NUM I-LF
+and CCONJ B-O
+a DET B-O
+complete ADJ B-O
+protease NOUN B-O
+inhibitor NOUN B-O
+cocktail NOUN B-O
+( PUNCT B-O
+Roche PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Baseline ADJ B-O
+categorical ADJ B-O
+data NOUN B-O
+are AUX B-O
+presented VERB B-O
+as ADP B-O
+frequency NOUN B-O
+( PUNCT B-O
+percent NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+continuous ADJ B-O
+data NOUN B-O
+are AUX B-O
+presented VERB B-O
+as ADP B-O
+median NOUN B-O
+( PUNCT B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+[ X B-O
+IQR PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+present ADJ B-O
+study NOUN B-O
+, PUNCT B-O
+we PRON B-O
+have AUX B-O
+examined VERB B-O
+the DET B-O
+possibility NOUN B-O
+that SCONJ B-O
+the DET B-O
+Fat1 PROPN B-AC
+cadherin NOUN B-O
+, PUNCT B-O
+a DET B-O
+planar NOUN B-LF
+cell NOUN I-LF
+polarity NOUN I-LF
+( PUNCT B-O
+PCP PROPN B-AC
+) PUNCT B-O
+molecule NOUN B-O
+involved VERB B-O
+in ADP B-O
+tissue NOUN B-O
+morphogenesis NOUN B-O
+, PUNCT B-O
+could AUX B-O
+contribute VERB B-O
+to PART B-O
+coordinate NOUN B-O
+muscular ADJ B-O
+and CCONJ B-O
+neuronal ADJ B-O
+morphogenesis NOUN B-O
+. PUNCT B-O
+
+TheRe PROPN B-AC
+is AUX B-O
+calculated VERB B-O
+by ADP B-O
+: PUNCT B-O
+Re PROPN B-AC
+= ADP B-O
+uwdbνw(18 NUM B-O
+) PUNCT B-O
+where SCONJ B-O
+uw PROPN B-AC
+( PUNCT B-O
+m PROPN B-AC
+/ NOUN B-O
+s PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+velocity NOUN B-O
+of ADP B-O
+water NOUN B-O
+, PUNCT B-O
+db PROPN B-AC
+( PUNCT B-O
+m PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+diameter NOUN B-O
+of ADP B-O
+heat NOUN B-O
+exchange NOUN B-O
+borehole NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+νw PROPN B-AC
+( PUNCT B-O
+m2 PROPN B-AC
+/ NOUN B-O
+s PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+dynamic ADJ B-LF
+viscosity NOUN I-LF
+of ADP I-LF
+water NOUN I-LF
+. PUNCT B-O
+
+Similarly ADV B-O
+, PUNCT B-O
+this DET B-O
+study NOUN B-O
+found VERB B-O
+HIV PROPN B-AC
+testing NOUN B-O
+as SCONJ B-O
+part NOUN B-O
+of ADP B-O
+the DET B-O
+requirements NOUN B-O
+of ADP B-O
+focused VERB B-O
+antenatal ADJ B-LF
+care NOUN I-LF
+package NOUN B-O
+to PART B-O
+be AUX B-O
+a DET B-O
+barrier NOUN B-O
+for SCONJ B-O
+both DET B-O
+men NOUN B-O
+and CCONJ B-O
+women NOUN B-O
+to PART B-O
+attend VERB B-O
+at ADP B-O
+ANC PROPN B-AC
+. PUNCT B-O
+
+It PRON B-O
+was AUX B-O
+noted VERB B-O
+that SCONJ B-O
+men NOUN B-O
+felt VERB B-O
+obligated ADJ B-O
+to PART B-O
+attend VERB B-O
+ANC PROPN B-AC
+with ADP B-O
+their PRON B-O
+partners NOUN B-O
+on ADP B-O
+the DET B-O
+first ADJ B-O
+ANC PROPN B-AC
+visit NOUN B-O
+so SCONJ B-O
+that SCONJ B-O
+their PRON B-O
+partners NOUN B-O
+may AUX B-O
+not PART B-O
+be AUX B-O
+denied VERB B-O
+services NOUN B-O
+when SCONJ B-O
+unaccompanied ADJ B-O
+, PUNCT B-O
+even ADV B-O
+as SCONJ B-O
+some PRON B-O
+dreaded VERB B-O
+HIV PROPN B-AC
+testing NOUN B-O
+. PUNCT B-O
+
+As SCONJ B-O
+the DET B-O
+Thai ADJ B-O
+Ministry PROPN B-LF
+of ADP I-LF
+Public PROPN I-LF
+Health PROPN I-LF
+( PUNCT B-O
+MoPH PROPN B-AC
+) NOUN B-O
+policy NOUN B-O
+requires VERB B-O
+insecticide NOUN B-O
+spraying NOUN B-O
+both CCONJ B-O
+upon SCONJ B-O
+identification NOUN B-O
+of ADP B-O
+a DET B-O
+dengue NOUN B-O
+case NOUN B-O
+and CCONJ B-O
+7 NUM B-O
+d NOUN B-O
+later ADV B-O
+, NOUN B-O
+the DET B-O
+study NOUN B-O
+team NOUN B-O
+provided VERB B-O
+the DET B-O
+initial ADJ B-O
+spraying NOUN B-O
+and CCONJ B-O
+the DET B-O
+Thai ADJ B-O
+MoPH PROPN B-AC
+provided VERB B-O
+the DET B-O
+day NOUN B-O
+7 NUM B-O
+spraying NOUN B-O
+( PUNCT B-O
+deltamethrin NOUN B-O
+or CCONJ B-O
+permethrin NOUN B-O
+10 NUM B-O
+% NOUN B-O
+) NOUN B-O
+, NOUN B-O
+regardless ADV B-O
+of ADP B-O
+the DET B-O
+dengue NOUN B-O
+PCR PROPN B-AC
+status NOUN B-O
+of ADP B-O
+the DET B-O
+index NOUN B-O
+case NOUN B-O
+for ADP B-O
+that DET B-O
+cluster NOUN B-O
+. PUNCT B-O
+
+EM PROPN B-O
+, PUNCT B-O
+electron NOUN B-O
+microscopy NOUN B-O
+; PUNCT B-O
+Fab PROPN B-AC
+, PUNCT B-O
+fragment NOUN B-LF
+antigen NOUN I-LF
+binding VERB I-LF
+; PUNCT B-O
+HA PROPN B-AC
+, PUNCT B-O
+hemagglutinin NOUN B-LF
+; PUNCT B-O
+nsEM PROPN B-AC
+, PUNCT B-O
+negative ADJ B-O
+- PUNCT B-O
+stain NOUN B-O
+EM PROPN B-O
+; PUNCT B-O
+PDB PROPN B-AC
+, PUNCT B-O
+Protein PROPN B-LF
+Data PROPN I-LF
+Bank PROPN I-LF
+. PUNCT B-O
+
+FI PROPN B-AC
+, PUNCT B-O
+RpfF NOUN B-LF
+interaction NOUN I-LF
+RpfF PROPN B-AC
+; PUNCT B-O
+PAS PROPN B-AC
+, PUNCT B-O
+Per PROPN B-LF
+- PUNCT I-LF
+Arnt PROPN I-LF
+- PUNCT I-LF
+Sim PROPN I-LF
+; PUNCT B-O
+RpfF PROPN B-AC
+, PUNCT B-O
+regulation NOUN B-LF
+of ADP I-LF
+pathogenicity NOUN I-LF
+factor NOUN I-LF
+F PROPN I-LF
+; PUNCT B-O
+RpfR PROPN B-AC
+, PUNCT B-O
+regulation NOUN B-LF
+of ADP I-LF
+pathogenicity NOUN I-LF
+factor NOUN I-LF
+R NOUN I-LF
+; PUNCT B-O
+SUMO PROPN B-AC
+, PUNCT B-O
+small ADJ B-LF
+ubiquitin NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+modifier NOUN I-LF
+. PUNCT B-O
+
+Effect NOUN B-O
+of ADP B-O
+non ADJ B-O
+- ADJ B-O
+Darcy ADJ B-O
+flow NOUN B-O
+can AUX B-O
+be PROPN B-AC
+considered VERB B-O
+by ADP B-O
+adjusting VERB B-O
+the DET B-O
+slip NOUN B-LF
+coefficient NOUN I-LF
+which PRON B-O
+appereas VERB B-O
+in ADP B-O
+Eq NOUN B-O
+( PUNCT B-O
+30 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+observe VERB B-O
+the DET B-O
+location NOUN B-O
+of ADP B-O
+P. PROPN B-O
+berghei PROPN B-O
+proteins NOUN B-O
+, PUNCT B-O
+the DET B-O
+C NOUN B-O
+- PUNCT B-O
+terminus NOUN B-O
+of ADP B-O
+the DET B-O
+gene NOUN B-O
+was AUX B-O
+tagged VERB B-O
+with ADP B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+GFP PROPN B-AC
+) PUNCT B-O
+sequence NOUN B-O
+by ADP B-O
+single ADJ B-O
+crossover NOUN B-O
+homologous ADJ B-O
+recombination NOUN B-O
+. PUNCT B-O
+
+Gestational ADJ B-LF
+diabetes NOUN I-LF
+mellitus NOUN I-LF
+( PUNCT B-O
+GDM PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+defined VERB B-O
+as ADP B-O
+any DET B-O
+degree NOUN B-O
+of ADP B-O
+glucose NOUN B-O
+intolerance NOUN B-O
+with ADP B-O
+onset NOUN B-O
+or CCONJ B-O
+first ADJ B-O
+recognition NOUN B-O
+during ADP B-O
+pregnancy NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Furthermore ADV B-O
+induction NOUN B-O
+of ADP B-O
+diabetes NOUN B-O
+type NOUN B-O
+1 NUM B-O
+induced VERB B-O
+a DET B-O
+decrease NOUN B-O
+in ADP B-O
+major ADJ B-O
+angiogenic ADJ B-O
+growth NOUN B-O
+factor NOUN B-O
+in ADP B-O
+the DET B-O
+skeletal ADJ B-O
+muscle NOUN B-O
+capillary ADJ B-O
+bed NOUN B-O
+of ADP B-O
+mice.[6 NOUN B-O
+] PUNCT B-O
+In ADP B-O
+a DET B-O
+chicken NOUN B-O
+model NOUN B-O
+of ADP B-O
+neoangiogenesis NOUN B-O
+, PUNCT B-O
+hyperglycemia NOUN B-O
+was AUX B-O
+shown VERB B-O
+to ADP B-O
+impair VERB B-O
+angiogenesis NOUN B-O
+through ADP B-O
+induction NOUN B-O
+of ADP B-O
+apoptosis NOUN B-O
+and CCONJ B-O
+decreases VERB B-O
+proliferation NOUN B-O
+of ADP B-O
+endothelial ADJ B-O
+cells.[7 NOUN B-O
+] PUNCT B-O
+In ADP B-O
+a DET B-O
+diabetic ADJ B-O
+mouse NOUN B-O
+model NOUN B-O
+with ADP B-O
+hindlimb NOUN B-O
+- ADJ B-O
+induced VERB B-O
+ischemia NOUN B-O
+, PUNCT B-O
+restoration NOUN B-O
+of ADP B-O
+perfusion NOUN B-O
+in ADP B-O
+the DET B-O
+ischemic ADJ B-O
+limb NOUN B-O
+was AUX B-O
+impaired VERB B-O
+and CCONJ B-O
+capillary ADJ B-O
+density NOUN B-O
+reduced.[8 VERB B-O
+] PUNCT B-O
+Goligorsky PROPN B-O
+and CCONJ B-O
+colleagues NOUN B-O
+demonstrated VERB B-O
+an DET B-O
+angiogenic ADJ B-O
+switch NOUN B-O
+during ADP B-O
+natural ADJ B-O
+history NOUN B-O
+of ADP B-O
+type NOUN B-LF
+2 NUM I-LF
+diabetes NOUN I-LF
+mellitus NOUN I-LF
+( PUNCT B-O
+T2DM PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+pro ADJ B-O
+- ADJ B-O
+angiogenic ADJ B-O
+phenotype NOUN B-O
+at ADP B-O
+the DET B-O
+early ADJ B-O
+pre ADJ B-O
+- ADJ B-O
+diabetic ADJ B-O
+stages NOUN B-O
+to ADP B-O
+the DET B-O
+profound ADJ B-O
+inhibition NOUN B-O
+of ADP B-O
+ex ADJ B-O
+- ADJ B-O
+vivo ADJ B-O
+angiogenesis NOUN B-O
+and CCONJ B-O
+microvascular ADJ B-O
+rarefaction NOUN B-O
+in ADP B-O
+the DET B-O
+kidneys NOUN B-O
+of ADP B-O
+obese ADJ B-O
+zucker PROPN B-O
+diabetic ADJ B-O
+fat ADJ B-O
+rats.[5 NOUN B-O
+] PUNCT B-O
+Peritubular ADJ B-O
+capillary ADJ B-O
+rarefaction NOUN B-O
+is VERB B-O
+a DET B-O
+major ADJ B-O
+hallmark NOUN B-O
+of ADP B-O
+chronic ADJ B-O
+kidney NOUN B-O
+disease NOUN B-O
+and CCONJ B-O
+predicts VERB B-O
+renal ADJ B-O
+outcome NOUN B-O
+in ADP B-O
+diabetic ADJ B-O
+nephropathy.[9 NOUN B-O
+] PUNCT B-O
+There PRON B-O
+is VERB B-O
+evidence NOUN B-O
+from ADP B-O
+animal NOUN B-O
+models NOUN B-O
+that SCONJ B-O
+endothelial ADJ B-O
+dysfunction NOUN B-O
+, PUNCT B-O
+oxidative ADJ B-O
+stress NOUN B-O
+, PUNCT B-O
+interstitial ADJ B-O
+hypoxia NOUN B-O
+due ADP B-O
+to ADP B-O
+arteriolar ADJ B-O
+vasoconstriction NOUN B-O
+and CCONJ B-O
+pericyte NOUN B-O
+detachment NOUN B-O
+from ADP B-O
+the DET B-O
+vasculature NOUN B-O
+are AUX B-O
+involved VERB B-O
+in ADP B-O
+this DET B-O
+pathophysiological ADJ B-O
+process.[9 NOUN B-O
+] PUNCT B-O
+Initially ADV B-O
+thought VERB B-O
+to PART B-O
+be AUX B-O
+absent ADJ B-O
+in ADP B-O
+mammals NOUN B-O
+, PUNCT B-O
+small ADJ B-O
+quantities NOUN B-O
+of ADP B-O
+α PUNCT B-O
+- PUNCT B-O
+linked VERB B-O
+monoglycosylceramides NOUN B-O
+( PUNCT B-O
+e.g. X B-O
+, PUNCT B-O
+α PUNCT B-LF
+- PUNCT I-LF
+galactosylceramide NOUN I-LF
+[ PUNCT B-O
+α-GalCer PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+that PRON B-O
+may AUX B-O
+act VERB B-O
+as ADP B-O
+iNKT PROPN B-AC
+cell NOUN B-O
+self NOUN B-O
+- PUNCT B-O
+Ags PROPN B-AC
+have AUX B-O
+been AUX B-O
+identified VERB B-O
+[ PUNCT B-O
+14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+effect NOUN B-O
+size NOUN B-O
+for ADP B-O
+the DET B-O
+primary ADJ B-O
+and CCONJ B-O
+secondary ADJ B-O
+outcomes NOUN B-O
+was AUX B-O
+evaluated VERB B-O
+as ADP B-O
+the DET B-O
+standardized ADJ B-LF
+mean NOUN I-LF
+difference NOUN I-LF
+( PUNCT B-O
+SMD PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+testing VERB B-O
+frequency NOUN B-O
+between ADP B-O
+intervention NOUN B-O
+and CCONJ B-O
+control NOUN B-O
+arms NOUN B-O
+. PUNCT B-O
+
+Activation NOUN B-O
+of ADP B-O
+MET PROPN B-AC
+signaling NOUN B-O
+cascade NOUN B-O
+by ADP B-O
+its PRON B-O
+ligand NOUN B-O
+HGF PROPN B-O
+results VERB B-O
+in ADP B-O
+colony NOUN B-O
+dispersal NOUN B-O
+, PUNCT B-O
+epithelial ADJ B-LF
+- PUNCT I-LF
+mesenchymal NOUN I-LF
+transition NOUN I-LF
+( PUNCT B-O
+EMT PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+increased VERB B-O
+motility NOUN B-O
+[ PUNCT B-O
+40 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+When SCONJ B-O
+DCs PROPN B-AC
+mature VERB B-O
+, PUNCT B-O
+they PRON B-O
+synthesize VERB B-O
+high ADJ B-O
+levels NOUN B-O
+of ADP B-O
+NO PROPN B-AC
+, PUNCT B-O
+interleukin NOUN B-LF
+( PUNCT B-O
+IL PROPN B-AC
+) PUNCT B-O
+12 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+RANTES PROPN B-AC
+, PUNCT B-O
+and CCONJ B-O
+express VERB B-O
+more ADV B-O
+costimulatory ADJ B-O
+molecules NOUN B-O
+such ADJ B-O
+as ADP B-O
+CD86 PROPN B-O
+and CCONJ B-O
+major ADJ B-LF
+histocompatibility NOUN I-LF
+complex NOUN I-LF
+( PUNCT B-O
+MHC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+all PRON B-O
+of ADP B-O
+which PRON B-O
+can AUX B-O
+induce VERB B-O
+T NOUN B-O
+cells NOUN B-O
+to ADP B-O
+become VERB B-O
+fully ADV B-O
+activated ADJ B-O
+to ADP B-O
+initial ADJ B-O
+immune ADJ B-O
+response NOUN B-O
+[ PUNCT B-O
+19 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Clot NOUN B-O
+formation NOUN B-O
+inside ADP B-O
+one NUM B-O
+of ADP B-O
+the DET B-O
+veins NOUN B-O
+deep ADJ B-O
+in ADP B-O
+the DET B-O
+body NOUN B-O
+( PUNCT B-O
+usually ADV B-O
+in ADP B-O
+a DET B-O
+leg NOUN B-O
+) PUNCT B-O
+is AUX B-O
+called VERB B-O
+deep ADJ B-LF
+vein NOUN I-LF
+thrombosis NOUN I-LF
+( PUNCT B-O
+DVT PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+DVT PROPN B-AC
+, PUNCT B-O
+which PRON B-O
+can AUX B-O
+cause VERB B-O
+pain NOUN B-O
+, PUNCT B-O
+swelling NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+redness NOUN B-O
+in ADP B-O
+the DET B-O
+affected VERB B-O
+limb NOUN B-O
+, PUNCT B-O
+is AUX B-O
+treated VERB B-O
+with ADP B-O
+anticoagulants NOUN B-O
+, PUNCT B-O
+drugs NOUN B-O
+that PRON B-O
+stop VERB B-O
+the DET B-O
+clot NOUN B-O
+growing VERB B-O
+. PUNCT B-O
+
+This DET B-O
+complex NOUN B-O
+is AUX B-O
+mainly ADV B-O
+composed VERB B-O
+of ADP B-O
+four NUM B-O
+subunits NOUN B-O
+: PUNCT B-O
+a DET B-O
+heterodimer NOUN B-O
+of ADP B-O
+two NUM B-O
+structural ADJ B-LF
+maintenance NOUN I-LF
+of ADP I-LF
+chromosome NOUN I-LF
+proteins NOUN I-LF
+( PUNCT B-O
+SMC1 PROPN B-O
+and CCONJ B-O
+SMC3 PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+associated VERB B-O
+with ADP B-O
+two NUM B-O
+non ADJ B-O
+- ADJ B-O
+SMC PROPN B-AC
+components NOUN B-O
+corresponding VERB B-O
+to ADP B-O
+sister NOUN B-O
+chromatid NOUN B-O
+cohesion NOUN B-O
+proteins NOUN B-O
+( PUNCT B-O
+SCC1 PROPN B-O
+and CCONJ B-O
+SCC3 PROPN B-O
+) PUNCT B-O
+[ X B-O
+3–6 NUM B-O
+] PUNCT B-O
+; PUNCT B-O
+and CCONJ B-O
+for ADP B-O
+review NOUN B-O
+see VERB B-O
+[ X B-O
+7,8 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Using VERB B-O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+high ADJ I-LF
+- PUNCT I-LF
+resolution NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT B-O
+LC-HR-MS/MS PROPN B-AC
+) PUNCT B-O
+analysis NOUN B-O
+, PUNCT B-O
+we PRON B-O
+discovered VERB B-O
+1,360 NUM B-O
+differentially ADV B-O
+expressed VERB B-O
+proteins NOUN B-O
+in ADP B-O
+CLL PROPN B-AC
+patients NOUN B-O
+compared VERB B-O
+to PART B-O
+healthy ADJ B-O
+donors NOUN B-O
+, PUNCT B-O
+several ADJ B-O
+of ADP B-O
+which PRON B-O
+had AUX B-O
+been AUX B-O
+previously ADV B-O
+reported VERB B-O
+to PART B-O
+be AUX B-O
+associated VERB B-O
+with ADP B-O
+cancer NOUN B-O
+, PUNCT B-O
+yet CCONJ B-O
+four NUM B-O
+of ADP B-O
+which PRON B-O
+were AUX B-O
+identified VERB B-O
+as ADP B-O
+being AUX B-O
+associated VERB B-O
+with ADP B-O
+any DET B-O
+cancer NOUN B-O
+, PUNCT B-O
+including VERB B-O
+CLL PROPN B-AC
+, PUNCT B-O
+for ADP B-O
+the DET B-O
+first ADJ B-O
+time NOUN B-O
+. PUNCT B-O
+
+Similar ADJ B-O
+improvements NOUN B-O
+in ADP B-O
+systolic ADJ B-O
+and CCONJ B-O
+diastolic ADJ B-O
+BP PROPN B-AC
+to ADP B-O
+those PRON B-O
+observed VERB B-O
+in ADP B-O
+this DET B-O
+trial NOUN B-O
+of ADP B-O
+3.3 NUM B-O
+and CCONJ B-O
+1.4 NUM B-O
+mmHg NOUN B-O
+were AUX B-O
+reported VERB B-O
+in ADP B-O
+the DET B-O
+Heart PROPN B-LF
+Outcome PROPN I-LF
+Prevention PROPN I-LF
+Evaluation PROPN I-LF
+( PUNCT B-O
+HOPE PROPN B-AC
+) PUNCT B-O
+study NOUN B-O
+and CCONJ B-O
+were AUX B-O
+associated VERB B-O
+with ADP B-O
+a DET B-O
+22 NUM B-O
+% NOUN B-O
+reduction NOUN B-O
+in ADP B-O
+relative ADJ B-O
+risk NOUN B-O
+of ADP B-O
+cardiovascular ADJ B-O
+mortality NOUN B-O
+, PUNCT B-O
+myocardial ADJ B-O
+infarction NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+stroke NOUN B-O
+[ PUNCT B-O
+23 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+expression NOUN B-O
+of ADP B-O
+the DET B-O
+major ADJ B-O
+inflammatory ADJ B-O
+cytokines NOUN B-O
+, PUNCT B-O
+IL-6 PROPN B-AC
+, PUNCT B-O
+IL-1β NOUN B-O
+and CCONJ B-O
+TNF PROPN B-AC
+, PUNCT B-O
+in ADP B-O
+spinal ADJ B-O
+cords NOUN B-O
+of ADP B-O
+these DET B-O
+SOD1 NOUN B-O
+transgenic ADJ B-LF
+( PUNCT B-O
+-αTG PROPN B-AC
+) PUNCT B-O
+mice NOUN B-O
+were AUX B-O
+assessed VERB B-O
+by ADP B-O
+real ADJ B-O
+time NOUN B-O
+PCR NOUN B-O
+. PUNCT B-O
+
+Mice NOUN B-O
+were AUX B-O
+then ADV B-O
+crossed VERB B-O
+with ADP B-O
+IL-6(-/- PROPN B-AC
+) PUNCT B-O
+mice NOUN B-O
+to PART B-O
+generate VERB B-O
+SOD1TG NOUN B-O
+/ SYM B-O
+IL-6(-/- PROPN B-AC
+) PUNCT B-O
+mice NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+female ADJ B-O
+mouse NOUN B-LF
+embryo NOUN I-LF
+fibroblasts NOUN I-LF
+( PUNCT B-O
+MEFs PROPN B-AC
+) PUNCT B-O
+exhibiting VERB B-O
+DD NOUN B-O
+signals NOUN B-O
+for ADP B-O
+Pgk1 NOUN B-O
+, PUNCT B-O
+the DET B-O
+distribution NOUN B-O
+of ADP B-O
+D PROPN B-AC
+/ SYM B-O
+D PROPN B-AC
+intensity NOUN B-O
+ratios NOUN B-O
+centered VERB B-O
+around ADP B-O
+1 NUM B-O
+( PUNCT B-O
+Figure PROPN B-O
+1E NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+demonstrating VERB B-O
+that SCONJ B-O
+two NUM B-O
+replicated VERB B-O
+alleles NOUN B-O
+display VERB B-O
+equal ADJ B-O
+signal NOUN B-O
+intensities NOUN B-O
+. PUNCT B-O
+
+There PRON B-O
+is VERB B-O
+no DET B-O
+dignity NOUN B-O
+… PUNCT B-O
+. PUNCT B-O
+
+” PUNCT B-O
+Account NOUN B-O
+told VERB B-O
+by ADP B-O
+a DET B-O
+16 NUM B-O
+- PUNCT B-O
+year NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+Sudanese ADJ B-O
+boy NOUN B-O
+to ADP B-O
+Médecins PROPN B-LF
+Sans PROPN I-LF
+Frontières PROPN I-LF
+( PUNCT B-O
+MSF PROPN B-AC
+) PUNCT B-O
+staff NOUN B-O
+, PUNCT B-O
+after ADP B-O
+being AUX B-O
+rescued VERB B-O
+on ADP B-O
+the DET B-O
+Mediterranean PROPN B-O
+Sea PROPN B-O
+in ADP B-O
+August PROPN B-O
+2019 NUM B-O
+. PUNCT B-O
+
+To PART B-O
+examine VERB B-O
+and CCONJ B-O
+compare VERB B-O
+changes NOUN B-O
+in ADP B-O
+strength NOUN B-O
+and CCONJ B-O
+physical ADJ B-O
+function NOUN B-O
+from ADP B-O
+pre- ADJ B-O
+to ADP B-O
+post ADJ B-O
+- ADJ B-O
+diagnosis NOUN B-O
+among ADP B-O
+men NOUN B-O
+with ADP B-O
+prostate NOUN B-LF
+cancer ADJ I-LF
+( PUNCT B-O
+PC PROPN B-AC
+, PUNCT B-O
+[ X B-O
+cases NOUN B-O
+] PUNCT B-O
+) PUNCT B-O
+and CCONJ B-O
+matched VERB B-O
+non ADJ B-O
+- ADJ B-O
+cancer ADJ B-O
+controls NOUN B-O
+identified VERB B-O
+from ADP B-O
+the DET B-O
+Health PROPN B-O
+, PUNCT B-O
+Aging PROPN B-O
+and CCONJ B-O
+Body PROPN B-O
+Composition PROPN B-O
+( PUNCT B-O
+HealthABC PROPN B-AC
+) PUNCT B-O
+study NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+specific ADJ B-O
+expression NOUN B-O
+of ADP B-O
+desatF NOUN B-O
+in ADP B-O
+D. PROPN B-O
+melanogaster NOUN B-O
+females NOUN B-O
+was AUX B-O
+due ADJ B-O
+to ADP B-O
+a DET B-O
+special ADJ B-O
+cis ADJ B-LF
+- PUNCT I-LF
+regulatory ADJ I-LF
+element NOUN I-LF
+( PUNCT B-O
+CRE PROPN B-AC
+) PUNCT B-O
+located VERB B-O
+upstream ADV B-O
+of ADP B-O
+desatF NOUN B-O
+in ADP B-O
+D. PROPN B-O
+melanogaster NOUN B-O
+; PUNCT B-O
+the DET B-O
+CRE PROPN B-AC
+presented VERB B-O
+a DET B-O
+doublesex PROPN B-O
+protein NOUN B-O
+( PUNCT B-O
+Doublesx PROPN B-LF
+, PUNCT B-O
+Dsx PROPN B-AC
+) PUNCT B-O
+binding NOUN B-O
+site NOUN B-O
+that PRON B-O
+could AUX B-O
+be AUX B-O
+recognized VERB B-O
+by ADP B-O
+the DET B-O
+female NOUN B-O
+- PUNCT B-O
+specific ADJ B-O
+isoform NOUN B-O
+of ADP B-O
+Dsx PROPN B-AC
+( PUNCT B-O
+Dsx PROPN B-AC
+- PUNCT B-O
+F PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+binding NOUN B-O
+of ADP B-O
+Dsx PROPN B-AC
+- PUNCT B-O
+F PROPN B-O
+activated VERB B-O
+the DET B-O
+transcription NOUN B-O
+of ADP B-O
+desatF NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+male NOUN B-O
+- PUNCT B-O
+specific ADJ B-O
+Dsx PROPN B-AC
+showed VERB B-O
+no DET B-O
+regulatory ADJ B-O
+activity NOUN B-O
+, PUNCT B-O
+resulting VERB B-O
+in ADP B-O
+sexual ADJ B-O
+dimorphism NOUN B-O
+of ADP B-O
+desatF NOUN B-O
+expression NOUN B-O
+[ PUNCT B-O
+42 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+DEG PROPN B-AC
+, PUNCT B-O
+differentially ADV B-LF
+expressed VERB I-LF
+gene NOUN I-LF
+; PUNCT B-O
+IL-4 PROPN B-AC
+, PUNCT B-O
+interleukin-4 NOUN B-LF
+. PUNCT B-O
+
+This PRON B-O
+included VERB B-O
+the DET B-O
+integration NOUN B-O
+of ADP B-O
+principles NOUN B-O
+from ADP B-O
+Self PROPN B-LF
+- PUNCT I-LF
+Determination PROPN I-LF
+Theory PROPN I-LF
+( PUNCT B-O
+SDT PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+a DET B-O
+means NOUN B-O
+to PART B-O
+strengthen VERB B-O
+the DET B-O
+quality NOUN B-O
+, PUNCT B-O
+quantity NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+longevity NOUN B-O
+of ADP B-O
+motivation NOUN B-O
+to PART B-O
+change VERB B-O
+health NOUN B-O
+behaviours NOUN B-O
+[ PUNCT B-O
+25 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+PAM2 PROPN B-O
+Off PROPN B-O
+- PUNCT B-O
+Target NOUN B-O
+# NOUN B-O
+2 NUM B-O
+template NOUN B-O
+( PUNCT B-O
+accession NOUN B-O
+XM_021073251.1 NOUN B-O
+) PUNCT B-O
+is AUX B-O
+predicted VERB B-O
+to ADP B-O
+encode VERB B-O
+for ADP B-O
+an DET B-O
+mRNA NOUN B-O
+transcript NOUN B-O
+for ADP B-O
+aminoadipate NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT B-O
+AADAT PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+AADAT PROPN B-AC
+is AUX B-O
+an DET B-O
+enzyme NOUN B-O
+found VERB B-O
+primarily ADV B-O
+in ADP B-O
+the DET B-O
+brain NOUN B-O
+and CCONJ B-O
+known VERB B-O
+to ADP B-O
+catalyze VERB B-O
+the DET B-O
+transamination NOUN B-O
+of ADP B-O
+kynurenine NOUN B-O
+to ADP B-O
+kynurenic NOUN B-O
+acid NOUN B-O
+; PUNCT B-O
+AADAT PROPN B-AC
+is AUX B-O
+also ADV B-O
+responsible ADJ B-O
+for ADP B-O
+the DET B-O
+transamination NOUN B-O
+of ADP B-O
+aminoapidate NOUN B-O
+to ADP B-O
+alpha NOUN B-O
+- PUNCT B-O
+oxoadipate[17 NOUN B-O
+] PUNCT B-O
+. PUNCT B-O
+
+DIC PROPN B-AC
+, PUNCT B-O
+differential ADJ B-LF
+interference NOUN I-LF
+contrast NOUN I-LF
+; PUNCT B-O
+EXP1 PROPN B-AC
+, PUNCT B-O
+exported VERB B-LF
+protein NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+HA PROPN B-O
+, PUNCT B-O
+triple ADJ B-O
+hemagglutinin NOUN B-O
+tag NOUN B-O
+; PUNCT B-O
+KAHRP PROPN B-AC
+, PUNCT B-O
+knob NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+histidine NOUN I-LF
+- PUNCT I-LF
+rich ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+pA NOUN B-O
+, PUNCT B-O
+Picoampere NOUN B-O
+; PUNCT B-O
+PSAC PROPN B-AC
+, PUNCT B-O
+parasite NOUN B-LF
+surface NOUN I-LF
+anion NOUN I-LF
+channel NOUN I-LF
+; PUNCT B-O
+PVM PROPN B-AC
+, PUNCT B-O
+parasitophorous ADJ B-LF
+vacuolar ADJ I-LF
+membrane NOUN I-LF
+; PUNCT B-O
+RBC PROPN B-AC
+, PUNCT B-O
+red ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+; PUNCT B-O
+SBP1 PROPN B-AC
+, PUNCT B-O
+skeleton NOUN B-LF
+binding VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+insufficient ADJ B-O
+information NOUN B-O
+is AUX B-O
+available ADJ B-O
+on ADP B-O
+the DET B-O
+effects NOUN B-O
+of ADP B-O
+fluoride NOUN B-O
+on ADP B-O
+human ADJ B-LF
+embryonic ADJ I-LF
+stem NOUN I-LF
+cells NOUN I-LF
+( PUNCT B-O
+hESCs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+a DET B-O
+novel ADJ B-O
+in ADP B-O
+vitro X B-O
+humanized VERB B-O
+model NOUN B-O
+for ADP B-O
+analyzing VERB B-O
+the DET B-O
+embryotoxicities NOUN B-O
+of ADP B-O
+chemical ADJ B-O
+compounds NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+first ADJ B-O
+source NOUN B-O
+is AUX B-O
+the DET B-O
+Human PROPN B-LF
+Mortality PROPN I-LF
+Database PROPN I-LF
+( PUNCT B-O
+HMD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+consists VERB B-O
+of ADP B-O
+high ADJ B-O
+- PUNCT B-O
+quality NOUN B-O
+life NOUN B-O
+tables NOUN B-O
+mostly ADV B-O
+from ADP B-O
+Western ADJ B-O
+countries NOUN B-O
+. PUNCT B-O
+
+CsINV5 PROPN B-AC
+expression NOUN B-O
+in ADP B-O
+cultivar NOUN B-O
+SCZ PROPN B-AC
+increased VERB B-O
+by ADP B-O
+three NUM B-O
+folds NOUN B-O
+at ADP B-O
+CA2 NOUN B-O
+compared VERB B-O
+with ADP B-O
+less ADJ B-O
+than ADP B-O
+one NUM B-O
+fold NOUN B-O
+in ADP B-O
+YH9 PROPN B-AC
+( PUNCT B-O
+Fig NOUN B-O
+6B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Raffinose NOUN B-LF
+synthase NOUN I-LF
+gene NOUN I-LF
+CsRS2 PROPN B-AC
+, PUNCT B-O
+responsible ADJ B-O
+for ADP B-O
+synthesizing NOUN B-O
+of ADP B-O
+raffinose NOUN B-O
+, PUNCT B-O
+expression NOUN B-O
+was AUX B-O
+also ADV B-O
+increased VERB B-O
+during ADP B-O
+CA PROPN B-AC
+in ADP B-O
+variety NOUN B-O
+SCZ PROPN B-AC
+and CCONJ B-O
+then ADV B-O
+decreased VERB B-O
+following VERB B-O
+DA PROPN B-AC
+, PUNCT B-O
+while SCONJ B-O
+it PRON B-O
+had VERB B-O
+no DET B-O
+distinct ADJ B-O
+changes NOUN B-O
+during ADP B-O
+CA PROPN B-AC
+in ADP B-O
+YH9 PROPN B-AC
+( PUNCT B-O
+Fig NOUN B-O
+6B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+This PRON B-O
+suggested VERB B-O
+that SCONJ B-O
+the DET B-O
+genes NOUN B-O
+responsible ADJ B-O
+for ADP B-O
+sucrose NOUN B-O
+and CCONJ B-O
+raffinose NOUN B-O
+accumulation NOUN B-O
+acted VERB B-O
+positively ADV B-O
+to PART B-O
+regulate VERB B-O
+the DET B-O
+corresponding VERB B-O
+sugar NOUN B-O
+accumulation NOUN B-O
+in ADP B-O
+cold ADJ B-O
+treatment NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+did AUX B-O
+not PART B-O
+observe VERB B-O
+any DET B-O
+association NOUN B-O
+between ADP B-O
+the DET B-O
+grandmother NOUN B-O
+’s PART B-O
+smoking NOUN B-O
+during ADP B-O
+her PRON B-O
+pregnancy NOUN B-O
+and CCONJ B-O
+unilateral ADJ B-O
+retinoblastoma NOUN B-O
+risk NOUN B-O
+in ADP B-O
+the DET B-O
+grandchild NOUN B-O
+( PUNCT B-O
+OR PROPN B-AC
+, PUNCT B-O
+1.1 NUM B-O
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+, PUNCT B-O
+0.5–2.1 NUM B-O
+) PUNCT B-O
+with ADP B-O
+a DET B-O
+slightly ADV B-O
+increased VERB B-O
+risk NOUN B-O
+estimate NOUN B-O
+for ADP B-O
+bilateral ADJ B-O
+retinoblastoma NOUN B-O
+development NOUN B-O
+, PUNCT B-O
+but CCONJ B-O
+confidence NOUN B-LF
+intervals NOUN I-LF
+crossed VERB B-O
+the DET B-O
+null ADJ B-O
+( PUNCT B-O
+OR PROPN B-AC
+, PUNCT B-O
+1.3 NUM B-O
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+, PUNCT B-O
+0.5–3.1 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+Poisson PROPN B-LF
+generalized ADJ I-LF
+likelihood NOUN I-LF
+ratio NOUN I-LF
+( PUNCT B-O
+GLR PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+calculated VERB B-O
+for ADP B-O
+each DET B-O
+window NOUN B-O
+of ADP B-O
+observed VERB B-O
+and CCONJ B-O
+expected VERB B-O
+number NOUN B-O
+of ADP B-O
+cases NOUN B-O
+in SCONJ B-O
+order NOUN B-O
+to PART B-O
+identify VERB B-O
+statistically ADV B-O
+significant ADJ B-O
+high ADJ B-O
+risk NOUN B-O
+periods NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+experimentally ADV B-O
+addressed VERB B-O
+this DET B-O
+issue NOUN B-O
+by ADP B-O
+studying VERB B-O
+the DET B-O
+maternal ADJ B-O
+transmission NOUN B-O
+of ADP B-O
+random ADJ B-O
+mtDNA PROPN B-AC
+mutations NOUN B-O
+in ADP B-O
+mtDNA PROPN B-AC
+mutator NOUN B-O
+mice NOUN B-O
+expressing VERB B-O
+a DET B-O
+proofreading NOUN B-O
+- PUNCT B-O
+deficient VERB B-O
+mitochondrial ADJ B-LF
+DNA NOUN I-LF
+polymerase NOUN B-O
+. PUNCT B-O
+
+SE PROPN B-O
+: PUNCT B-O
+standard ADJ B-O
+error NOUN B-O
+, PUNCT B-O
+CI PROPN B-O
+: PUNCT B-O
+confidence NOUN B-O
+interval NOUN B-O
+, PUNCT B-O
+ANC PROPN B-AC
+: PUNCT B-O
+antenatal ADJ B-LF
+care NOUN I-LF
+, PUNCT B-O
+SHP PROPN B-O
+: PUNCT B-O
+skilled ADJ B-O
+health NOUN B-O
+professionals NOUN B-O
+Dichotomous ADJ B-O
+events NOUN B-O
+or CCONJ B-O
+odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT B-O
+ORs PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+suicide NOUN B-O
+, PUNCT B-O
+suicide NOUN B-O
+attempt NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+suicidal ADJ B-O
+ideation NOUN B-O
+were AUX B-O
+analyzed VERB B-O
+using VERB B-O
+multilevel ADJ B-O
+meta NOUN B-O
+- NOUN B-O
+analyses NOUN B-O
+to PART B-O
+accommodate VERB B-O
+the DET B-O
+non NOUN B-O
+- NOUN B-O
+independence NOUN B-O
+of ADP B-O
+effect NOUN B-O
+sizes NOUN B-O
+. PUNCT B-O
+
+DON PROPN B-AC
+, PUNCT B-O
+6 NUM B-LF
+- PUNCT I-LF
+Diazo-5 NOUN I-LF
+- PUNCT I-LF
+oxo NOUN I-LF
+- PUNCT I-LF
+L NOUN I-LF
+- PUNCT I-LF
+norleucine NOUN I-LF
+; PUNCT B-O
+IHC PROPN B-AC
+, PUNCT B-O
+immunohistochemistry NOUN B-LF
+; PUNCT B-O
+MEF PROPN B-AC
+, PUNCT B-O
+mouse NOUN B-LF
+embryonic ADJ I-LF
+fibroblast NOUN I-LF
+. PUNCT B-O
+
+We PRON B-O
+observed VERB B-O
+a DET B-O
+significant ADJ B-O
+drop NOUN B-O
+in ADP B-O
+the DET B-O
+level NOUN B-O
+of ADP B-O
+postoperative ADJ B-LF
+sVEGFR1 PROPN B-O
+than ADP B-O
+that PRON B-O
+of ADP B-O
+the DET B-O
+preoperative ADJ B-LF
+( PUNCT B-O
+median ADJ B-O
+sVEGFR1 PROPN B-O
+: PUNCT B-O
+PREOP PROPN B-AC
+, PUNCT B-O
+189.6 NUM B-O
+pg NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+; PUNCT B-O
+POST PROPN B-AC
+, PUNCT B-O
+124.3 NUM B-O
+pg NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+; PUNCT B-O
+P NOUN B-O
+< SYM B-O
+0.0001 NUM B-O
+; PUNCT B-O
+Fig NUM B-O
+5A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Unlike ADP B-O
+sVEGFR1 PROPN B-O
+, PUNCT B-O
+we PRON B-O
+did AUX B-O
+not PART B-O
+observe VERB B-O
+significant ADJ B-O
+difference NOUN B-O
+in ADP B-O
+the DET B-O
+level NOUN B-O
+of ADP B-O
+serum NOUN B-O
+sVEGFR2 NOUN B-O
+between ADP B-O
+the DET B-O
+two NUM B-O
+events NOUN B-O
+( PUNCT B-O
+median ADJ B-O
+sVEGFR2 NOUN B-O
+: PUNCT B-O
+OPPRE PROPN B-AC
+, PUNCT B-O
+7773 NUM B-O
+pg NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+; PUNCT B-O
+OPPOST PROPN B-AC
+, PUNCT B-O
+8306 NUM B-O
+pg NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+; PUNCT B-O
+P NOUN B-O
+= SYM B-O
+0.976 NUM B-O
+; PUNCT B-O
+Fig NUM B-O
+5B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+No DET B-O
+direct ADJ B-O
+association NOUN B-O
+between ADP B-O
+soluble ADJ B-O
+VEGF PROPN B-O
+receptors NOUN B-O
+and CCONJ B-O
+OPIPVEGF-A PROPN B-AC
+was AUX B-O
+noted VERB B-O
+. PUNCT B-O
+
+For ADP B-O
+mortality NOUN B-O
+, PUNCT B-O
+we PRON B-O
+examined VERB B-O
+deaths NOUN B-O
+from ADP B-O
+respiratory ADJ B-LF
+and CCONJ I-LF
+circulatory ADJ I-LF
+( PUNCT B-O
+R&C PROPN B-AC
+) PUNCT B-O
+conditions NOUN B-O
+as ADP B-O
+a DET B-O
+more ADV B-O
+specific ADJ B-O
+outcome NOUN B-O
+for ADP B-O
+influenza NOUN B-O
+. PUNCT B-O
+
+Although SCONJ B-O
+the DET B-O
+Preferred PROPN B-LF
+Reporting PROPN I-LF
+Items PROPN I-LF
+for ADP I-LF
+Systematic ADJ I-LF
+reviews NOUN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PUNCT I-LF
+Analyses PROPN I-LF
+( PUNCT B-O
+PRISMA PROPN B-AC
+) PUNCT B-O
+guidelines NOUN B-O
+have AUX B-O
+been AUX B-O
+critical ADJ B-O
+to ADP B-O
+the DET B-O
+proper ADJ B-O
+reporting VERB B-O
+of ADP B-O
+systematic ADJ B-O
+reviews NOUN B-O
+[ PUNCT B-O
+7,8 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+they PRON B-O
+lack VERB B-O
+specificity NOUN B-O
+for ADP B-O
+reporting VERB B-O
+systematic ADJ B-O
+reviews NOUN B-O
+of ADP B-O
+preclinical ADJ B-O
+research NOUN B-O
+. PUNCT B-O
+
+Differing VERB B-O
+in ADP B-O
+allele NOUN B-O
+frequency NOUN B-O
+across ADP B-O
+three NUM B-O
+population NOUN B-O
+comparisons NOUN B-O
+and CCONJ B-O
+associated VERB B-O
+with ADP B-O
+the DET B-O
+abundance NOUN B-O
+of ADP B-O
+Clostridiales NOUN B-O
+, NOUN B-O
+the DET B-O
+genetic ADJ B-O
+variant NOUN B-O
+rs7587067 NOUN B-O
+has VERB B-O
+a DET B-O
+significantly ADV B-O
+higher ADJ B-O
+frequency NOUN B-O
+in ADP B-O
+African ADJ B-O
+( PUNCT B-O
+minor ADJ B-LF
+allele NOUN I-LF
+frequency NOUN I-LF
+[ X B-O
+MAF PROPN B-AC
+] X B-O
+= PUNCT B-O
+0.802 NUM B-O
+) PUNCT B-O
+versus ADP B-O
+East ADJ B-O
+Asian ADJ B-O
+( PUNCT B-O
+MAF PROPN B-AC
+= PUNCT B-O
+0.190 NUM B-O
+, NOUN B-O
+FST PROPN B-AC
+= PUNCT B-O
+0.54 NUM B-O
+, NOUN B-O
+Chromosome NOUN B-O
+= PUNCT B-O
+98.7 NUM B-O
+% PUNCT B-O
+, NOUN B-O
+Genome NOUN B-O
+- PUNCT B-O
+Wide ADJ B-O
+= PUNCT B-O
+98.9 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+, NOUN B-O
+admixed ADJ B-O
+American PROPN B-O
+( PUNCT B-O
+MAF PROPN B-AC
+= PUNCT B-O
+0.278 NUM B-O
+, NOUN B-O
+FST PROPN B-AC
+= PUNCT B-O
+0.44 NUM B-O
+, NOUN B-O
+Chromosome NOUN B-O
+= PUNCT B-O
+99.0 NUM B-O
+% PUNCT B-O
+, NOUN B-O
+Genome NOUN B-O
+- PUNCT B-O
+Wide ADJ B-O
+= PUNCT B-O
+99.1 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+, NOUN B-O
+and CCONJ B-O
+European ADJ B-O
+populations NOUN B-O
+( PUNCT B-O
+MAF PROPN B-AC
+= PUNCT B-O
+0.267 NUM B-O
+, NOUN B-O
+FST PROPN B-AC
+= PUNCT B-O
+0.45 NUM B-O
+, NOUN B-O
+Chromosome NOUN B-O
+= PUNCT B-O
+98.7.3 NUM B-O
+% PUNCT B-O
+, NOUN B-O
+Genome NOUN B-O
+- PUNCT B-O
+Wide ADJ B-O
+= PUNCT B-O
+98.7 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Utilizing VERB B-O
+2 NUM B-O
+bulk ADJ B-O
+RNA-Seq PROPN B-AC
+datasets NOUN B-O
+( PUNCT B-O
+GSE63142 NUM B-O
+and CCONJ B-O
+GSE130499 PROPN B-O
+) PUNCT B-O
+of ADP B-O
+asthma NOUN B-O
+patients NOUN B-O
+compared VERB B-O
+to ADP B-O
+healthy ADJ B-O
+controls NOUN B-O
+, PUNCT B-O
+we PRON B-O
+identified VERB B-O
+that SCONJ B-O
+IRAK3 PROPN B-O
+and CCONJ B-O
+ADRB2 PROPN B-O
+had VERB B-O
+significantly ADV B-O
+elevated VERB B-O
+expression NOUN B-O
+( PUNCT B-O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+[ X B-O
+FDR PROPN B-AC
+] X B-O
+< ADP B-O
+0.05 NUM B-O
+) PUNCT B-O
+in ADP B-O
+asthma NOUN B-O
+patients NOUN B-O
+. PUNCT B-O
+
+As ADP B-O
+a DET B-O
+robust ADJ B-O
+fiduciary ADJ B-O
+marker NOUN B-O
+for ADP B-O
+CCPs PROPN B-AC
+, PUNCT B-O
+clathrin PROPN B-LF
+light PROPN I-LF
+chain NOUN I-LF
+a DET I-LF
+( PUNCT B-O
+CLCa PROPN B-AC
+) PUNCT B-O
+carrying VERB B-O
+an DET B-O
+N NOUN B-O
+- PUNCT B-O
+terminal ADJ B-O
+SNAP PROPN B-O
+- PUNCT B-O
+fusion NOUN B-O
+tag NOUN B-O
+was AUX B-O
+stably ADV B-O
+introduced VERB B-O
+in ADP B-O
+parallel ADJ B-O
+into ADP B-O
+both DET B-O
+cell NOUN B-O
+lines NOUN B-O
+via ADP B-O
+a DET B-O
+lentiviral ADJ B-O
+vector NOUN B-O
+with ADP B-O
+puromycin NOUN B-O
+selection NOUN B-O
+of ADP B-O
+SNAP PROPN B-O
+- PUNCT B-O
+CLCa PROPN B-AC
+expressing VERB B-O
+cells NOUN B-O
+. PUNCT B-O
+
+From ADP B-O
+S6 PROPN B-O
+Fig NOUN B-O
+, PUNCT B-O
+it PRON B-O
+can AUX B-O
+also ADV B-O
+be AUX B-O
+seen VERB B-O
+that SCONJ B-O
+upon SCONJ B-O
+binding VERB B-O
+to ADP B-O
+dabrafenib NOUN B-O
+, PUNCT B-O
+radius NOUN B-LF
+of ADP I-LF
+gyration NOUN I-LF
+value NOUN B-O
+( PUNCT B-O
+Rg PROPN B-AC
+) PUNCT B-O
+significantly ADV B-O
+decreased VERB B-O
+. PUNCT B-O
+
+CHD PROPN B-AC
+, PUNCT B-O
+coronary ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+; PUNCT B-O
+FMD PROPN B-AC
+, PUNCT B-O
+flow NOUN B-LF
+- PUNCT I-LF
+mediated VERB I-LF
+dilation NOUN I-LF
+; PUNCT B-O
+HCAEC PROPN B-AC
+, PUNCT B-O
+human ADJ B-LF
+coronary ADJ I-LF
+artery NOUN I-LF
+endothelial ADJ I-LF
+cell NOUN I-LF
+; PUNCT B-O
+PCNA PROPN B-O
+, PUNCT B-O
+proliferating VERB B-O
+cell NOUN B-O
+nuclear ADJ B-O
+antigen NOUN B-O
+. PUNCT B-O
+
+Previous ADJ B-O
+connectivity NOUN B-O
+studies NOUN B-O
+using VERB B-O
+EEG PROPN B-AC
+have AUX B-O
+found VERB B-O
+synchronized VERB B-O
+beta NOUN B-O
+frequency NOUN B-O
+oscillations NOUN B-O
+in ADP B-O
+the DET B-O
+basal ADJ B-LF
+ganglia NOUN I-LF
+( PUNCT B-O
+BG PROPN B-AC
+) PUNCT B-O
+including VERB B-O
+cortical ADJ B-O
+- PUNCT B-O
+thalamic ADJ B-O
+, PUNCT B-O
+EGP NOUN B-O
+/ SYM B-O
+IGP NOUN B-O
+- PUNCT B-O
+thalamic ADJ B-O
+, PUNCT B-O
+cortical ADJ B-O
+- PUNCT B-O
+striatal ADJ B-O
+, PUNCT B-O
+striatal ADJ B-O
+- PUNCT B-O
+EGP NOUN B-O
+/ SYM B-O
+IGP NOUN B-O
+and CCONJ B-O
+cortical ADJ B-O
+- PUNCT B-O
+SN NOUN B-O
+pars NOUN B-O
+reticulata NOUN B-O
+connections NOUN B-O
+[ X B-O
+68 NUM B-O
+, PUNCT B-O
+69 NUM B-O
+] PUNCT B-O
+indicating VERB B-O
+increased VERB B-O
+functional ADJ B-O
+coupling NOUN B-O
+between ADP B-O
+these DET B-O
+brain NOUN B-O
+structures NOUN B-O
+in ADP B-O
+6-OHDA PROPN B-AC
+rats NOUN B-O
+. PUNCT B-O
+
+DIC PROPN B-AC
+, PUNCT B-O
+differential ADJ B-LF
+interference NOUN I-LF
+contrast NOUN I-LF
+; PUNCT B-O
+dsRNA PROPN B-AC
+, PUNCT B-O
+double ADJ B-LF
+- PUNCT I-LF
+stranded ADJ I-LF
+RNA NOUN I-LF
+; PUNCT B-O
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+Oo NOUN B-O
+, PUNCT B-O
+oocyte NOUN B-O
+; PUNCT B-O
+Sp NOUN B-O
+, PUNCT B-O
+sperm NOUN B-O
+; PUNCT B-O
+RNAi PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT B-O
+RT PROPN B-AC
+, PUNCT B-O
+Reverse ADJ B-LF
+transcription NOUN I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+. PUNCT B-O
+
+Population NOUN B-O
+density NOUN B-O
+is AUX B-O
+measured VERB B-O
+using VERB B-O
+light NOUN B-O
+scattering NOUN B-O
+( PUNCT B-O
+optical ADJ B-LF
+density NOUN I-LF
+[ PUNCT B-O
+OD PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+drug NOUN B-O
+concentration NOUN B-O
+can AUX B-O
+be AUX B-O
+adjusted VERB B-O
+in ADP B-O
+real ADJ B-O
+time NOUN B-O
+in ADP B-O
+response NOUN B-O
+to ADP B-O
+population NOUN B-O
+dynamics NOUN B-O
+or CCONJ B-O
+predetermined VERB B-O
+protocols NOUN B-O
+( PUNCT B-O
+S1 NUM B-O
+Fig NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Esophageal ADJ B-LF
+adenocarcinoma NOUN I-LF
+( PUNCT B-O
+EAC PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+predominantly ADV B-O
+a DET B-O
+disease NOUN B-O
+of ADP B-O
+the DET B-O
+distal ADJ B-O
+esophagus NOUN B-O
+and CCONJ B-O
+gastroesophageal ADJ B-O
+junction NOUN B-O
+. PUNCT B-O
+
+Atherosclerosis NOUN B-O
+is AUX B-O
+the DET B-O
+major ADJ B-O
+cause NOUN B-O
+for ADP B-O
+developing VERB B-O
+vascular ADJ B-O
+events NOUN B-O
+[ PUNCT B-O
+2,13–18 NUM B-O
+] PUNCT B-O
+including VERB B-O
+ischemic ADJ B-O
+heart NOUN B-O
+disease NOUN B-O
+, PUNCT B-O
+heart NOUN B-O
+failure NOUN B-O
+, PUNCT B-O
+stroke NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+peripheral ADJ B-LF
+arterial ADJ I-LF
+occlusive ADJ I-LF
+disease NOUN I-LF
+( PUNCT B-O
+PAOD PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+genetic ADJ B-O
+manipulation NOUN B-O
+study NOUN B-O
+comparing VERB B-O
+double ADJ B-O
+( PUNCT B-O
+apolipoprotein NOUN B-O
+E NOUN B-O
+and CCONJ B-O
+eNOS PROPN B-AC
+) PUNCT B-O
+knockout NOUN B-O
+with ADP B-O
+single ADJ B-O
+( PUNCT B-O
+apolipoprotein NOUN B-O
+E NOUN B-O
+) PUNCT B-O
+knockout NOUN B-O
+model NOUN B-O
+demonstrate VERB B-O
+that SCONJ B-O
+eNOS PROPN B-AC
+deficiency NOUN B-O
+increases VERB B-O
+atherosclerosis NOUN B-O
+in ADP B-O
+Western ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+diet NOUN B-O
+- PUNCT B-O
+fed VERB B-O
+single ADJ B-O
+( PUNCT B-O
+apolipoprotein NOUN B-O
+E NOUN B-O
+) PUNCT B-O
+knockout NOUN B-O
+mice NOUN B-O
+and CCONJ B-O
+introduces VERB B-O
+an DET B-O
+array NOUN B-O
+of ADP B-O
+cardiovascular ADJ B-O
+complications NOUN B-O
+, PUNCT B-O
+including VERB B-O
+myocardial ADJ B-O
+infarction NOUN B-O
+, PUNCT B-O
+heart NOUN B-O
+failure NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+spontaneous ADJ B-O
+aortic ADJ B-O
+aneurysm NOUN B-O
+and CCONJ B-O
+dissection NOUN B-O
+[ PUNCT B-O
+18 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Five NUM B-O
+different ADJ B-O
+tissues NOUN B-O
+and CCONJ B-O
+organs NOUN B-O
+of ADP B-O
+P. NOUN B-O
+tepidariorum NOUN B-O
+– PUNCT B-O
+the DET B-O
+midgut NOUN B-LF
+glands NOUN I-LF
+with ADP I-LF
+midgut NOUN I-LF
+( PUNCT B-O
+MG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+neuroendocrine ADJ B-LF
+and CCONJ I-LF
+nervous ADJ I-LF
+system NOUN I-LF
+( PUNCT B-O
+NS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+ovaries NOUN B-LF
+( PUNCT B-O
+OV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+hindgut NOUN B-LF
+( PUNCT B-O
+HG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+integument NOUN B-LF
+( PUNCT B-O
+INT)–were PROPN B-AC
+used VERB B-O
+for ADP B-O
+the DET B-O
+analysis NOUN B-O
+. PUNCT B-O
+
+SDMA PROPN B-AC
+concentrations NOUN B-O
+were AUX B-O
+determined VERB B-O
+using VERB B-O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+- PUNCT I-LF
+mass NOUN I-LF
+spectroscopy NOUN I-LF
+( PUNCT B-O
+LC-MS PROPN B-AC
+) PUNCT B-O
+as SCONJ B-O
+previously ADV B-O
+described VERB B-O
+[ PUNCT B-O
+6 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+HR PROPN B-AC
+, PUNCT B-O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+SD PROPN B-AC
+, PUNCT B-O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+RE PROPN B-AC
+-ZINB PROPN B-AC
+, PUNCT B-O
+random ADJ B-LF
+- PUNCT I-LF
+effects NOUN I-LF
+zero NUM B-LF
+- PUNCT I-LF
+inflated VERB I-LF
+negative ADJ I-LF
+binomial NOUN I-LF
+; PUNCT B-O
+IRR PROPN B-AC
+, PUNCT B-O
+incidence NOUN B-LF
+rate NOUN I-LF
+ratio NOUN I-LF
+; PUNCT B-O
+CI NOUN B-O
+, PUNCT B-O
+confidence NOUN B-O
+interval NOUN B-O
+; PUNCT B-O
+OR PROPN B-AC
+, PUNCT B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+LLIN PROPN B-AC
+, PUNCT B-O
+long ADV B-LF
+- PUNCT I-LF
+lasting VERB I-LF
+insecticidal ADJ I-LF
+bed NOUN I-LF
+net NOUN I-LF
+; PUNCT B-O
+IRS PROPN B-AC
+, PUNCT B-O
+indoor ADJ B-LF
+residual ADJ I-LF
+spraying NOUN I-LF
+. PUNCT B-O
+
+Trajectories NOUN B-O
+of ADP B-O
+HAQ PROPN B-AC
+scores NOUN B-O
+over ADP B-O
+follow NOUN B-O
+- PUNCT B-O
+up NOUN B-O
+were AUX B-O
+assessed VERB B-O
+using VERB B-O
+latent ADJ B-LF
+class NOUN I-LF
+growth NOUN I-LF
+models NOUN I-LF
+( PUNCT B-O
+LCGMs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+multivariate ADJ B-O
+logistic ADJ B-O
+regression NOUN B-O
+model NOUN B-O
+was AUX B-O
+fit ADJ B-O
+to PART B-O
+determine VERB B-O
+the DET B-O
+association NOUN B-O
+between ADP B-O
+the DET B-O
+patient NOUN B-O
+specific ADJ B-O
+factors NOUN B-O
+and CCONJ B-O
+the DET B-O
+occurrence NOUN B-O
+of ADP B-O
+the DET B-O
+different ADJ B-O
+types NOUN B-O
+of ADP B-O
+DTPs PROPN B-AC
+. PUNCT B-O
+
+Comparison NOUN B-O
+of ADP B-O
+factors NOUN B-O
+contributing VERB B-O
+for ADP B-O
+drug NOUN B-LF
+therapy NOUN I-LF
+problems NOUN I-LF
+were AUX B-O
+shown VERB B-O
+using VERB B-O
+odd ADJ B-O
+ratios NOUN B-O
+. PUNCT B-O
+
+Because SCONJ B-O
+loss NOUN B-O
+of ADP B-O
+CG6866 NOUN B-O
+function NOUN B-O
+de VERB B-O
+- PUNCT B-O
+silences VERB B-O
+both CCONJ B-O
+endogenous ADJ B-O
+silencing NOUN B-O
+and CCONJ B-O
+reporter NOUN B-O
+expression NOUN B-O
+in ADP B-O
+vivo ADV B-O
+( PUNCT B-O
+below ADV B-O
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+named VERB B-O
+the DET B-O
+gene NOUN B-O
+loquacious ADJ B-O
+( PUNCT B-O
+loqs PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+loqs PROPN B-O
+is AUX B-O
+located VERB B-O
+on ADP B-O
+the DET B-O
+left ADJ B-O
+arm NOUN B-O
+of ADP B-O
+Chromosome NOUN B-O
+2 NUM B-O
+at ADP B-O
+polytene NOUN B-O
+band NOUN B-O
+34B9 NUM B-O
+. PUNCT B-O
+
+loqs PROPN B-O
+produces VERB B-O
+at ADP B-O
+least ADV B-O
+three NUM B-O
+different ADJ B-O
+mRNA NOUN B-O
+isoforms NOUN B-O
+through ADP B-O
+alternative ADJ B-O
+splicing NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+1B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+shortest ADJ B-O
+transcript NOUN B-O
+, PUNCT B-O
+loqs PROPN B-O
+RNA NOUN B-LF
+splice NOUN I-LF
+variant NOUN I-LF
+A PROPN I-LF
+( PUNCT B-O
+RA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+encodes VERB B-O
+a DET B-O
+419 NUM B-O
+- PUNCT B-O
+amino NOUN B-O
+- PUNCT B-O
+acid NOUN B-O
+protein NOUN B-O
+, PUNCT B-O
+Loqs PROPN B-O
+protein NOUN B-LF
+isoform NOUN I-LF
+A PROPN I-LF
+( PUNCT B-O
+PA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+a DET B-O
+predicted VERB B-O
+molecular ADJ B-O
+mass NOUN B-O
+of ADP B-O
+45 NUM B-O
+kDa NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+transcript NOUN B-O
+loqs PROPN B-O
+RNA NOUN B-LF
+splice NOUN I-LF
+variant NOUN I-LF
+B PROPN I-LF
+( PUNCT B-O
+RB PROPN B-AC
+) PUNCT B-O
+contains VERB B-O
+one NUM B-O
+additional ADJ B-O
+exon NOUN B-O
+and CCONJ B-O
+encodes VERB B-O
+a DET B-O
+protein NOUN B-O
+of ADP B-O
+465 NUM B-O
+amino NOUN B-O
+acids NOUN B-O
+, PUNCT B-O
+Loqs PROPN B-O
+protein NOUN B-LF
+isoform NOUN I-LF
+B PROPN I-LF
+( PUNCT B-O
+PB PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+a DET B-O
+predicted VERB B-O
+molecular ADJ B-O
+mass NOUN B-O
+of ADP B-O
+50 NUM B-O
+kDa NOUN B-O
+. PUNCT B-O
+
+These DET B-O
+two NUM B-O
+mRNA NOUN B-O
+species NOUN B-O
+were AUX B-O
+identified VERB B-O
+as ADP B-O
+cDNAs NOUN B-O
+in ADP B-O
+the DET B-O
+Drosophila PROPN B-O
+genome NOUN B-O
+sequencing NOUN B-O
+project NOUN B-O
+and CCONJ B-O
+annotated VERB B-O
+in ADP B-O
+FlyBase PROPN B-O
+[ X B-O
+38 NUM B-O
+] X B-O
+among ADP B-O
+the DET B-O
+Drosophila PROPN B-O
+proteins NOUN B-O
+that PRON B-O
+contain VERB B-O
+dsRBDs PROPN B-AC
+. PUNCT B-O
+
+Using VERB B-O
+non ADJ B-O
+- PUNCT B-O
+quantitative ADJ B-O
+RT NOUN B-O
+- PUNCT B-O
+PCR NOUN B-O
+, PUNCT B-O
+we PRON B-O
+detected VERB B-O
+a DET B-O
+third ADJ B-O
+splice NOUN B-O
+variant NOUN B-O
+, PUNCT B-O
+loqs PROPN B-O
+RNA NOUN B-LF
+splice NOUN I-LF
+variant NOUN I-LF
+C PROPN I-LF
+( PUNCT B-O
+RC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+which PRON B-O
+an DET B-O
+alternative ADJ B-O
+splice NOUN B-O
+acceptor NOUN B-O
+site NOUN B-O
+for ADP B-O
+exon NOUN B-O
+4 NUM B-O
+is AUX B-O
+used VERB B-O
+( PUNCT B-O
+Figure PROPN B-O
+1B NUM B-O
+, PUNCT B-O
+C PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+D NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Use NOUN B-O
+of ADP B-O
+the DET B-O
+alternative ADJ B-O
+splice NOUN B-O
+site NOUN B-O
+creates VERB B-O
+a DET B-O
+5′-extended ADJ B-O
+fourth ADJ B-O
+exon NOUN B-O
+and CCONJ B-O
+changes VERB B-O
+the DET B-O
+reading NOUN B-O
+frame NOUN B-O
+, PUNCT B-O
+resulting VERB B-O
+in ADP B-O
+a DET B-O
+truncated VERB B-O
+protein NOUN B-O
+, PUNCT B-O
+Loqs PROPN B-O
+protein NOUN B-LF
+isoform NOUN I-LF
+C PROPN I-LF
+( PUNCT B-O
+PC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+383 NUM B-O
+amino NOUN B-O
+acids NOUN B-O
+long ADJ B-O
+( PUNCT B-O
+Figure PROPN B-O
+1C NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Loqs PROPN B-O
+PC PROPN B-AC
+has VERB B-O
+a DET B-O
+predicted VERB B-O
+molecular ADJ B-O
+mass NOUN B-O
+of ADP B-O
+41 NUM B-O
+kDa NOUN B-O
+and CCONJ B-O
+lacks VERB B-O
+the DET B-O
+entire ADJ B-O
+third ADJ B-O
+dsRBD PROPN B-AC
+of ADP B-O
+Loqs PROPN B-O
+PA PROPN B-AC
+and CCONJ B-O
+PB PROPN B-AC
+( PUNCT B-O
+Figure PROPN B-O
+1B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+loqs PROPN B-O
+RA PROPN B-AC
+is AUX B-O
+the DET B-O
+predominant ADJ B-O
+mRNA NOUN B-O
+species NOUN B-O
+in ADP B-O
+dissected ADJ B-O
+testes NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+loqs PROPN B-O
+RB PROPN B-AC
+is AUX B-O
+the DET B-O
+most ADV B-O
+abundant ADJ B-O
+species NOUN B-O
+in ADP B-O
+ovaries NOUN B-O
+. PUNCT B-O
+
+Autotaxin PROPN B-LF
+( PUNCT B-O
+ATX PROPN B-AC
+) PUNCT B-O
+has VERB B-O
+a DET B-O
+profibrotic ADJ B-O
+effect NOUN B-O
+resulting VERB B-O
+from ADP B-O
+lysophosphatidic ADJ B-O
+acid NOUN B-O
+activity NOUN B-O
+. PUNCT B-O
+
+Only ADV B-O
+markers NOUN B-O
+with ADP B-O
+known VERB B-O
+map NOUN B-O
+positions NOUN B-O
+were AUX B-O
+used VERB B-O
+to PART B-O
+perform VERB B-O
+linkage NOUN B-LF
+disequilibrium NOUN I-LF
+( PUNCT B-O
+LD PROPN B-AC
+) PUNCT B-O
+analysis NOUN B-O
+with ADP B-O
+TASSEL PROPN B-O
+3.0 NUM B-O
+[ PUNCT B-O
+37 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Response NOUN B-O
+: PUNCT B-O
+Sucrose NOUN B-O
+in ADP B-O
+full ADJ B-O
+form NOUN B-O
+in ADP B-O
+heading NOUN B-O
+or CCONJ B-O
+subheadings NOUN B-O
+has AUX B-O
+been AUX B-O
+mentioned VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+“ PUNCT B-O
+Determination PROPN B-O
+of ADP B-O
+Chl PROPN B-AC
+Precursors NOUN B-O
+” PUNCT B-O
+has AUX B-O
+been AUX B-O
+replaced VERB B-O
+by ADP B-O
+“ PUNCT B-O
+Determination PROPN B-O
+of ADP B-O
+Chlorophyll PROPN B-LF
+Precursors NOUN B-O
+” PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+was AUX B-O
+approved VERB B-O
+by ADP B-O
+the DET B-O
+institutional ADJ B-O
+review NOUN B-O
+boards NOUN B-O
+of ADP B-O
+Kyoto PROPN B-LF
+Prefectural PROPN I-LF
+University PROPN I-LF
+of ADP I-LF
+Medicine PROPN I-LF
+( PUNCT B-O
+KPUM PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+National PROPN B-O
+Institute PROPN B-O
+of ADP B-O
+Health PROPN B-O
+Sciences PROPN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+ITH PROPN B-AC
+( PUNCT B-O
+intra ADJ B-LF
+- PUNCT I-LF
+tumour ADJ I-LF
+heterogeneity NOUN I-LF
+) PUNCT B-O
+, PUNCT B-O
+OC PROPN B-AC
+( PUNCT B-O
+ovarian ADJ B-O
+carcinoma NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+BRCA PROPN B-AC
+( PUNCT B-O
+breast ADJ B-LF
+cancer NOUN I-LF
+invasive ADJ I-LF
+carcinoma NOUN I-LF
+) PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+are AUX B-O
+available ADJ B-O
+from ADP B-O
+the DET B-O
+Ethical PROPN B-O
+Review PROPN B-O
+Committee PROPN B-O
+and/or CCONJ B-O
+Research PROPN B-O
+Administration PROPN B-O
+of ADP B-O
+International PROPN B-LF
+Centre PROPN I-LF
+for ADP I-LF
+Diarrhoeal PROPN I-LF
+Disease PROPN I-LF
+Research PROPN I-LF
+, X I-LF
+Bangladesh PROPN I-LF
+( PUNCT B-O
+icddr,b PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+researchers NOUN B-O
+who PRON B-O
+meet VERB B-O
+the DET B-O
+criteria NOUN B-O
+for ADP B-O
+access NOUN B-O
+to ADP B-O
+confidential ADJ B-O
+data NOUN B-O
+. PUNCT B-O
+
+Results NOUN B-O
+are AUX B-O
+presented VERB B-O
+as ADP B-O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratios NOUN I-LF
+( PUNCT B-O
+aOR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+their PRON B-O
+p NOUN B-O
+- PUNCT B-O
+values NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A X B-O
+) PUNCT B-O
+Gene NOUN B-O
+induction NOUN B-O
+determined VERB B-O
+by ADP B-O
+qRT-PCR PROPN B-AC
+with ADP B-O
+parental ADJ B-O
+( PUNCT B-O
+S2-/- PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+stably ADV B-O
+STAT2 PROPN B-O
+- PUNCT B-O
+reconstituted VERB B-O
+( PUNCT B-O
+S2 PROPN B-O
+WT PROPN B-AC
+or CCONJ B-O
+S2 PROPN B-O
+L82A NOUN B-O
+) PUNCT B-O
+human ADJ B-O
+U6A PROPN B-O
+cells NOUN B-O
+after ADP B-O
+treatment NOUN B-O
+with ADP B-O
+IFN PROPN B-AC
+- PUNCT B-O
+β PUNCT B-O
+( PUNCT B-O
+500 NUM B-O
+U NOUN B-O
+/ NOUN B-O
+ml NOUN B-O
+) PUNCT B-O
+for ADP B-O
+4 NUM B-O
+h. NOUN B-O
+( PUNCT B-O
+B X B-O
+) PUNCT B-O
+STAT1 PROPN B-O
+- PUNCT B-O
+CFP PROPN B-AC
+and CCONJ B-O
+YFP PROPN B-AC
+- PUNCT B-O
+tagged VERB B-O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT B-O
+top ADJ B-O
+panels NOUN B-O
+) PUNCT B-O
+or CCONJ B-O
+L82A NOUN B-O
+mutated VERB B-O
+STAT2 PROPN B-O
+( PUNCT B-O
+bottom ADJ B-O
+panels NOUN B-O
+) PUNCT B-O
+were AUX B-O
+co VERB B-O
+- PUNCT B-O
+expressed VERB B-O
+in ADP B-O
+HeLa PROPN B-O
+cells NOUN B-O
+and CCONJ B-O
+their PRON B-O
+subcellular ADJ B-O
+localization NOUN B-O
+was AUX B-O
+observed VERB B-O
+by ADP B-O
+deconvolution NOUN B-O
+microscopy NOUN B-O
+after ADP B-O
+1 NUM B-O
+h NOUN B-O
+in ADP B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+IFN PROPN B-AC
+- PUNCT B-O
+β PUNCT B-O
+. PUNCT B-O
+
+1Treatments NOUN B-O
+: PUNCT B-O
+CON PROPN B-AC
+= PUNCT B-O
+Piglets NOUN B-O
+drenched VERB B-O
+with ADP B-O
+2 NUM B-O
+mL NOUN B-O
+tap NOUN B-O
+water NOUN B-O
+until ADP B-O
+d NOUN B-O
+7 NUM B-O
+; PUNCT B-O
+T1 NOUN B-O
+= PUNCT B-O
+Piglets NOUN B-O
+drenched VERB B-O
+with ADP B-O
+1 NUM B-O
+g NOUN B-O
+short ADJ B-LF
+- PUNCT I-LF
+chain NOUN I-LF
+fructo NOUN I-LF
+- PUNCT I-LF
+oligosaccharides NOUN I-LF
+( PUNCT B-O
+scFOS PROPN B-AC
+, PUNCT B-O
+Profeed PROPN B-O
+P95 PROPN B-O
+, PUNCT B-O
+Beghin PROPN B-O
+- PUNCT B-O
+Meiji PROPN B-O
+) PUNCT B-O
+dissolved VERB B-O
+in ADP B-O
+2 NUM B-O
+mL NOUN B-O
+tap NOUN B-O
+water NOUN B-O
+until ADP B-O
+d NOUN B-O
+7 NUM B-O
+; PUNCT B-O
+T2 NOUN B-O
+= PUNCT B-O
+Piglets NOUN B-O
+drenched VERB B-O
+with ADP B-O
+1 NUM B-O
+g NOUN B-O
+scFOS PROPN B-AC
+dissolved VERB B-O
+in ADP B-O
+2 NUM B-O
+mL NOUN B-O
+tap NOUN B-O
+water NOUN B-O
+until ADP B-O
+d NOUN B-O
+21.5 NUM B-O
+( PUNCT B-O
+weaning NOUN B-O
+age NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Safety NOUN B-O
+assessments NOUN B-O
+were AUX B-O
+performed VERB B-O
+in ADP B-O
+a DET B-O
+standardized ADJ B-O
+method NOUN B-O
+at ADP B-O
+each DET B-O
+study NOUN B-O
+visit NOUN B-O
+and CCONJ B-O
+included VERB B-O
+the DET B-O
+evaluation NOUN B-O
+of ADP B-O
+adverse ADJ B-LF
+events NOUN I-LF
+( PUNCT B-O
+AEs PROPN B-AC
+): PUNCT B-O
+serious ADJ B-O
+AEs PROPN B-AC
+( PUNCT B-O
+SAEs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+severe ADJ B-O
+AEs PROPN B-AC
+, PUNCT B-O
+treatment NOUN B-O
+- PUNCT B-O
+related VERB B-O
+AEs PROPN B-AC
+, PUNCT B-O
+procedure NOUN B-O
+- PUNCT B-O
+related VERB B-O
+AEs PROPN B-AC
+( PUNCT B-O
+i.e. X B-O
+The DET B-O
+second ADJ B-O
+objective NOUN B-O
+was AUX B-O
+to PART B-O
+evaluate VERB B-O
+the DET B-O
+utility NOUN B-O
+of ADP B-O
+‘ PUNCT B-O
+TB PROPN B-AC
+Transport NOUN B-O
+’ PUNCT B-O
+( PUNCT B-O
+containing VERB B-O
+Trans-Filter PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+‘ PUNCT B-O
+TB PROPN B-AC
+DNA NOUN B-O
+Extraction NOUN B-O
+’ PUNCT B-O
+kits NOUN B-O
+for ADP B-O
+sputum NOUN B-O
+transport NOUN B-O
+, PUNCT B-O
+tuberculosis NOUN B-LF
+M.tuberculosis PROPN B-AC
+DNA NOUN B-O
+isolation NOUN B-O
+and CCONJ B-O
+Mol-DST PROPN B-AC
+assay NOUN B-O
+, PUNCT B-O
+taking VERB B-O
+phenotypic ADJ B-O
+DST NOUN B-O
+as ADP B-O
+the DET B-O
+reference NOUN B-O
+standard NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+here ADV B-O
+show VERB B-O
+that SCONJ B-O
+cell NOUN B-O
+- PUNCT B-O
+type NOUN B-O
+– AUX B-O
+specific ADJ B-O
+reduction NOUN B-O
+of ADP B-O
+cyclin NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+kinase NOUN I-LF
+5 NUM I-LF
+( PUNCT B-O
+cdk5 PROPN B-AC
+) PUNCT B-O
+activity NOUN B-O
+in ADP B-O
+newborn ADJ B-O
+neurons NOUN B-O
+results VERB B-O
+in ADP B-O
+impaired VERB B-O
+neuronal ADJ B-O
+migration NOUN B-O
+and CCONJ B-O
+leads VERB B-O
+to ADP B-O
+the DET B-O
+extension NOUN B-O
+of ADP B-O
+incorrectly ADV B-O
+targeted VERB B-O
+neuronal ADJ B-O
+processes NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+we PRON B-O
+performed VERB B-O
+disuccinimidyl NOUN B-LF
+sulfoxide NOUN I-LF
+( PUNCT B-O
+DSSO PROPN B-AC
+: PUNCT B-O
+a DET B-O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+- PUNCT B-O
+cleavable ADJ B-O
+crosslinker NOUN B-O
+) PUNCT B-O
+crosslinking NOUN B-O
+of ADP B-O
+kindlin-3 NOUN B-O
+monomer NOUN B-O
+and CCONJ B-O
+trimer NOUN B-O
+followed VERB B-O
+by ADP B-O
+analytical ADJ B-O
+gel NOUN B-O
+filtration NOUN B-O
+and CCONJ B-O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+( PUNCT B-O
+MS PROPN B-AC
+) PUNCT B-O
+analysis NOUN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+ART PROPN B-AC
+, PUNCT B-O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT B-O
+CI PROPN B-AC
+, PUNCT B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT B-O
+HAZ PROPN B-AC
+, PUNCT B-O
+WHO PROPN B-AC
+height NOUN B-O
+- PUNCT B-O
+for ADP B-O
+- PUNCT B-O
+age NOUN B-O
+Z NOUN B-O
+- PUNCT B-O
+score NOUN B-O
+; PUNCT B-O
+IQR PROPN B-AC
+, PUNCT B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+; PUNCT B-O
+LTFU PROPN B-AC
+, PUNCT B-O
+loss NOUN B-O
+to PART B-O
+follow VERB B-O
+- PUNCT B-O
+up ADP B-O
+. PUNCT B-O
+
+Since SCONJ B-O
+fructose NOUN B-O
+metabolism NOUN B-O
+is VERB B-O
+insulin NOUN B-O
+- PUNCT B-O
+independent ADJ B-O
+[ PUNCT B-O
+2 X B-O
+] PUNCT B-O
+, PUNCT B-O
+there PRON B-O
+is VERB B-O
+less ADJ B-O
+uptake NOUN B-O
+and CCONJ B-O
+catabolism NOUN B-O
+of ADP B-O
+triglyceride NOUN B-LF
+( PUNCT B-O
+TG)-rich PROPN B-AC
+lipoproteins NOUN B-O
+by ADP B-O
+tissues NOUN B-O
+, PUNCT B-O
+ultimately ADV B-O
+resulting VERB B-O
+in ADP B-O
+increased VERB B-O
+postprandial ADJ B-O
+plasma NOUN B-O
+TG PROPN B-AC
+levels NOUN B-O
+[ PUNCT B-O
+8 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+CONSORT PROPN B-AC
+has AUX B-O
+been AUX B-O
+endorsed VERB B-O
+by ADP B-O
+the DET B-O
+World PROPN B-LF
+Association PROPN I-LF
+of ADP I-LF
+Medical PROPN I-LF
+Editors PROPN I-LF
+( PUNCT B-O
+WAME PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+International PROPN B-LF
+Committee PROPN I-LF
+of ADP I-LF
+Medical PROPN I-LF
+Journal PROPN I-LF
+Editors PROPN I-LF
+( PUNCT B-O
+ICMJE PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+Council PROPN B-LF
+of ADP I-LF
+Science PROPN I-LF
+Editors PROPN I-LF
+( PUNCT B-O
+CSE PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Currently ADV B-O
+, PUNCT B-O
+however ADV B-O
+, PUNCT B-O
+the DET B-O
+CONSORT PROPN B-AC
+Statement PROPN B-O
+provides VERB B-O
+limited ADJ B-O
+guidance NOUN B-O
+about ADP B-O
+preparing VERB B-O
+abstracts NOUN B-O
+and CCONJ B-O
+, PUNCT B-O
+while SCONJ B-O
+it PRON B-O
+encourages VERB B-O
+the DET B-O
+use NOUN B-O
+of ADP B-O
+a DET B-O
+structured ADJ B-O
+format NOUN B-O
+, PUNCT B-O
+this PRON B-O
+is AUX B-O
+not PART B-O
+a DET B-O
+formal ADJ B-O
+requirement NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+correlate VERB B-O
+responsiveness NOUN B-O
+of ADP B-O
+ccRCC PROPN B-AC
+cell NOUN B-O
+lines NOUN B-O
+to ADP B-O
+established VERB B-O
+forms NOUN B-O
+of ADP B-O
+treatments NOUN B-O
+with ADP B-O
+extent NOUN B-O
+of ADP B-O
+genomic ADJ B-O
+aberrations NOUN B-O
+, PUNCT B-O
+we PRON B-O
+analyzed VERB B-O
+a DET B-O
+subset NOUN B-O
+of ADP B-O
+malignant ADJ B-O
+clear ADJ B-O
+cell NOUN B-O
+renal ADJ B-O
+cell NOUN B-O
+lines NOUN B-O
+, PUNCT B-O
+via ADP B-O
+The DET B-LF
+Cancer PROPN I-LF
+Genome PROPN I-LF
+Atlas PROPN I-LF
+( PUNCT B-O
+TCGA PROPN B-AC
+: PUNCT B-O
+[ X B-O
+28 NUM B-O
+, PUNCT B-O
+29 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+are AUX B-O
+means NOUN B-O
+± SYM B-O
+s.d NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+* PUNCT B-O
+p NOUN B-O
+= X B-O
+0.06 NUM B-O
+, PUNCT B-O
+* PUNCT B-O
+* PUNCT B-O
+p NOUN B-O
+= X B-O
+0.0012 NUM B-O
+, PUNCT B-O
+* PUNCT B-O
+* PUNCT B-O
+* PUNCT B-O
+p NOUN B-O
+= X B-O
+0.0005 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+β PUNCT B-O
+- PUNCT B-O
+Galactosidase NOUN B-O
+( PUNCT B-O
+puc-lacZ PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+purple ADJ B-O
+; PUNCT B-O
+Ptc PROPN B-AC
+, PUNCT B-O
+green NOUN B-O
+; PUNCT B-O
+DAPI NOUN B-O
+, PUNCT B-O
+turquoise NOUN B-O
+; PUNCT B-O
+En PROPN B-AC
+, PUNCT B-O
+red NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+A NOUN B-O
+– PUNCT B-O
+C PROPN B-O
+) PUNCT B-O
+( PUNCT B-O
+right ADJ B-O
+panels NOUN B-O
+) PUNCT B-O
+Scheme NOUN B-O
+of ADP B-O
+the DET B-O
+phenotype NOUN B-O
+and CCONJ B-O
+expression NOUN B-O
+patterns NOUN B-O
+of ADP B-O
+Wg PROPN B-AC
+and CCONJ B-O
+En PROPN B-AC
+; PUNCT B-O
+PS PROPN B-AC
+is AUX B-O
+for ADP B-O
+parasegment NOUN B-LF
+boundary NOUN B-O
+and CCONJ B-O
+S PROPN B-O
+for ADP B-O
+segment NOUN B-O
+boundary NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D X B-O
+) PUNCT B-O
+Model NOUN B-O
+of ADP B-O
+JNK PROPN B-O
+induced VERB B-O
+reprogramming NOUN B-O
+at ADP B-O
+the DET B-O
+segment NOUN B-O
+boundary NOUN B-O
+and CCONJ B-O
+Wg PROPN B-AC
+inhibition NOUN B-O
+at ADP B-O
+the DET B-O
+parasegment NOUN B-LF
+boundary NOUN B-O
+. PUNCT B-O
+
+More ADV B-O
+recently ADV B-O
+, PUNCT B-O
+several ADJ B-O
+PCP PROPN B-AC
+pathway NOUN B-O
+components NOUN B-O
+, PUNCT B-O
+like ADP B-O
+the DET B-O
+Wnt NOUN B-O
+receptor NOUN B-O
+Frizzled PROPN B-LF
+( PUNCT B-O
+Fz PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Flamingo PROPN B-LF
+( PUNCT B-O
+Fmi PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Strabismus PROPN B-O
+( PUNCT B-O
+Stbm PROPN B-O
+or CCONJ B-O
+Vang PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+Dsh PROPN B-AC
+, PUNCT B-O
+have AUX B-O
+been AUX B-O
+shown VERB B-O
+to PART B-O
+play VERB B-O
+a DET B-O
+role NOUN B-O
+in ADP B-O
+the DET B-O
+correct ADJ B-O
+targeting NOUN B-O
+and CCONJ B-O
+bifurcation NOUN B-O
+of ADP B-O
+MB PROPN B-AC
+axons NOUN B-O
+[ PUNCT B-O
+4],[30],[31 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Error NOUN B-O
+bars NOUN B-O
+denote VERB B-O
+standard ADJ B-LF
+errors NOUN I-LF
+of ADP I-LF
+means NOUN I-LF
+( PUNCT B-O
+SEM PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Underlying VERB B-O
+data NOUN B-O
+can AUX B-O
+be AUX B-O
+found VERB B-O
+in ADP B-O
+S1 PROPN B-O
+Data PROPN B-O
+. PUNCT B-O
+
+Thus ADV B-O
+, PUNCT B-O
+we PRON B-O
+here ADV B-O
+decided VERB B-O
+to PART B-O
+perform VERB B-O
+all DET B-O
+reactions NOUN B-O
+in ADP B-O
+DMSO NOUN B-O
+- PUNCT B-O
+free ADJ B-O
+aqueous ADJ B-O
+buffers NOUN B-O
+using VERB B-O
+N NOUN B-LF
+, PUNCT I-LF
+N NOUN I-LF
+, PUNCT I-LF
+N’,N’,N”-pentamethyldiethylenetriamine NOUN I-LF
+( PUNCT B-O
+PMDETA PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+a DET B-O
+Cu NOUN B-O
+( PUNCT B-O
+I NOUN B-O
+) PUNCT B-O
+stabilizing VERB B-O
+agent NOUN B-O
+for ADP B-O
+the DET B-O
+conjugation NOUN B-O
+of ADP B-O
+the DET B-O
+RNA NOUN B-O
+aptamer NOUN B-O
+Gint4.T PROPN B-O
+to PART B-O
+MP PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+advantage NOUN B-O
+of ADP B-O
+PMDETA PROPN B-AC
+is AUX B-O
+its PRON B-O
+water NOUN B-O
+solubility NOUN B-O
+and CCONJ B-O
+ease NOUN B-O
+to PART B-O
+separate VERB B-O
+from ADP B-O
+the DET B-O
+reaction NOUN B-O
+mixture NOUN B-O
+upon SCONJ B-O
+purification NOUN B-O
+of ADP B-O
+the DET B-O
+conjugate NOUN B-O
+[ PUNCT B-O
+27 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Human ADJ B-LF
+papillomavirus NOUN I-LF
+( PUNCT B-O
+HPV PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+name NOUN B-O
+of ADP B-O
+a DET B-O
+group NOUN B-O
+of ADP B-O
+viruses NOUN B-O
+that PRON B-O
+includes VERB B-O
+more ADJ B-O
+than ADP B-O
+100 NUM B-O
+different ADJ B-O
+strains NOUN B-O
+or CCONJ B-O
+types NOUN B-O
+; PUNCT B-O
+more ADJ B-O
+than ADP B-O
+30 NUM B-O
+of ADP B-O
+these DET B-O
+viruses NOUN B-O
+are AUX B-O
+sexually ADV B-O
+transmitted VERB B-O
+. PUNCT B-O
+
+From ADP B-O
+those DET B-O
+predictive ADJ B-O
+models NOUN B-O
+the DET B-O
+performance NOUN B-O
+( PUNCT B-O
+i.e. X B-O
+, PUNCT B-O
+ROCAUC PROPN B-AC
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+, PUNCT B-O
+CI PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+classifying VERB B-O
+the DET B-O
+input NOUN B-O
+phenotypic ADJ B-O
+groups NOUN B-O
+( PUNCT B-O
+e.g. X B-O
+, PUNCT B-O
+cases NOUN B-O
+versus ADP B-O
+controls NOUN B-O
+) PUNCT B-O
+are AUX B-O
+provided VERB B-O
+. PUNCT B-O
+
+Flow NOUN B-O
+cytometry NOUN B-O
+analysis NOUN B-O
+of ADP B-O
+uterine ADJ B-O
+implantation NOUN B-O
+sites NOUN B-O
+following VERB B-O
+removal NOUN B-O
+of ADP B-O
+the DET B-O
+placenta NOUN B-O
+/ SYM B-O
+embryo NOUN B-O
+demonstrated VERB B-O
+that SCONJ B-O
+the DET B-O
+percentage NOUN B-O
+of ADP B-O
+BM PROPN B-AC
+- NOUN B-O
+derived VERB B-O
+GFP+ PROPN B-AC
+cells NOUN B-O
+in ADP B-O
+the DET B-O
+implantation NOUN B-O
+site NOUN B-O
+increased VERB B-O
+as SCONJ B-O
+pregnancy NOUN B-O
+progressed VERB B-O
+to ADP B-O
+mid NOUN B-O
+- NOUN B-O
+gestation NOUN B-O
+; PUNCT B-O
+it PRON B-O
+increased VERB B-O
+significantly ADV B-O
+on ADP B-O
+the DET B-O
+day NOUN B-O
+of ADP B-O
+implantation NOUN B-O
+( PUNCT B-O
+E5.5 NUM B-O
+) PUNCT B-O
+( PUNCT B-O
+15.8 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+as SCONJ B-O
+compared VERB B-O
+with ADP B-O
+the DET B-O
+nonpregnant ADJ B-O
+state NOUN B-O
+( PUNCT B-O
+9.2 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+peaking VERB B-O
+on ADP B-O
+E9.5 NUM B-O
+( PUNCT B-O
+24.1 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+followed VERB B-O
+by ADP B-O
+a DET B-O
+gradual ADJ B-O
+decrease NOUN B-O
+on ADP B-O
+E13.5 NUM B-O
+( PUNCT B-O
+16.7 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+peripartum NOUN B-O
+( PUNCT B-O
+E17.5 NUM B-O
+) PUNCT B-O
+( PUNCT B-O
+13.1 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Fig NOUN B-O
+1D NUM B-O
+and CCONJ B-O
+1F NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+As SCONJ B-O
+the DET B-O
+observed VERB B-O
+increase NOUN B-O
+in ADP B-O
+GFP+ PROPN B-AC
+cells NOUN B-O
+in ADP B-O
+the DET B-O
+decidua NOUN B-O
+during ADP B-O
+pregnancy NOUN B-O
+could AUX B-O
+be AUX B-O
+due ADJ B-O
+to ADP B-O
+local ADJ B-O
+proliferation NOUN B-O
+of ADP B-O
+BMDCs PROPN B-AC
+and CCONJ B-O
+not PART B-O
+only ADV B-O
+to ADP B-O
+increased VERB B-O
+recruitment NOUN B-O
+, PUNCT B-O
+we PRON B-O
+assessed VERB B-O
+cell NOUN B-O
+proliferation NOUN B-O
+using VERB B-O
+proliferating VERB B-LF
+cell NOUN I-LF
+nuclear ADJ I-LF
+antigen NOUN I-LF
+( PUNCT B-O
+PCNA PROPN B-AC
+) PUNCT B-O
+staining NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+characterize VERB B-O
+its PRON B-O
+carbohydrate NOUN B-O
+utilization NOUN B-O
+capabilities NOUN B-O
+, PUNCT B-O
+we PRON B-O
+defined VERB B-O
+its PRON B-O
+growth NOUN B-O
+in ADP B-O
+minimal ADJ B-LF
+medium NOUN I-LF
+( PUNCT B-O
+MM PROPN B-AC
+) PUNCT B-O
+supplemented VERB B-O
+with ADP B-O
+one NUM B-O
+of ADP B-O
+46 NUM B-O
+different ADJ B-O
+carbohydrates NOUN B-O
+[ PUNCT B-O
+25 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Col-0 PROPN B-AC
+, PUNCT B-O
+Columbia-0 PROPN B-LF
+; PUNCT B-O
+CTL1 PROPN B-AC
+, PUNCT B-O
+choline NOUN B-LF
+transporter NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+1 NUM I-LF
+; PUNCT B-O
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+FM4 PROPN B-AC
+, PUNCT B-O
+N-(3 NOUN B-LF
+- PUNCT I-LF
+Triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium NOUN I-LF
+dibromide NOUN I-LF
+; PUNCT B-O
+-64NRAMP1 PROPN B-AC
+, PUNCT B-O
+natural ADJ B-LF
+resistance NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+macrophage NOUN I-LF
+protein NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+PDCB PROPN B-AC
+, PUNCT B-O
+plasmodesmata NOUN B-LF
+callose NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+; PUNCT B-O
+sic1 PROPN B-AC
+, PUNCT B-O
+significant ADJ B-LF
+ionome NOUN I-LF
+changes NOUN I-LF
+1 NUM I-LF
+. PUNCT B-O
+
+Line NOUN B-O
+156 NUM B-O
+: PUNCT B-O
+‘ PUNCT B-O
+Clustering VERB B-O
+bootstrapping NOUN B-O
+was AUX B-O
+performed VERB B-O
+to PART B-O
+evaluate VERB B-O
+the DET B-O
+significance NOUN B-O
+of ADP B-O
+patient NOUN B-O
+- NOUN B-O
+specific ADJ B-O
+clusters NOUN B-O
+using VERB B-O
+the DET B-O
+pvclust NOUN B-O
+R NOUN B-O
+package NOUN B-O
+( PUNCT B-O
+1000 NUM B-O
+repetitions NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+significance NOUN B-O
+were AUX B-O
+estimated VERB B-O
+by ADP B-O
+Approximately ADV B-LF
+Unbiased ADJ I-LF
+( PUNCT B-O
+AU PROPN B-AC
+) PUNCT B-O
+p NOUN B-O
+- NOUN B-O
+values NOUN B-O
+: PUNCT B-O
+Clusters NOUN B-O
+were AUX B-O
+considered VERB B-O
+significant ADJ B-O
+for ADP B-O
+AU PROPN B-AC
+values NOUN B-O
+≥95 NUM B-O
+, PUNCT B-O
+which PRON B-O
+indicates VERB B-O
+a DET B-O
+significance NOUN B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+≤0.05 NUM B-O
+[ PUNCT B-O
+30 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+’ PUNCT B-O
+B X B-O
+, PUNCT B-O
+Anti ADJ B-O
+- ADJ B-O
+FXIII PROPN B-AC
+autoantibody NOUN B-O
+levels NOUN B-O
+measured VERB B-O
+using VERB B-O
+ICT PROPN B-AC
+( PUNCT B-O
+arbitrary ADJ B-LF
+unit NOUN I-LF
+; PUNCT B-O
+AU PROPN B-AC
+) PUNCT B-O
+as SCONJ B-O
+described VERB B-O
+in ADP B-O
+“ PUNCT B-O
+Materials PROPN B-O
+and CCONJ B-O
+Methods PROPN B-O
+” PUNCT B-O
+in ADP B-O
+reference NOUN B-O
+allele NOUN B-O
+( PUNCT B-O
+T NOUN B-O
+/ SYM B-O
+T NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+heterozygous ADJ B-O
+allele NOUN B-O
+( PUNCT B-O
+T NOUN B-O
+/ SYM B-O
+C NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+homozygous ADJ B-O
+allele NOUN B-O
+( PUNCT B-O
+C NOUN B-O
+/ SYM B-O
+C NOUN B-O
+) PUNCT B-O
+at ADP B-O
+chromosome NOUN B-O
+6 NUM B-O
+; PUNCT B-O
+32363816 NUM B-O
+in ADP B-O
+BTNL2 NOUN B-O
+( PUNCT B-O
+rs2076530 NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Moreover ADV B-O
+, PUNCT B-O
+Tau PROPN B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+also ADV B-O
+known VERB B-O
+as ADP B-O
+microtubule NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+tau NOUN I-LF
+( PUNCT B-O
+Mapt PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+is AUX B-O
+abundant ADJ B-O
+in ADP B-O
+neurons NOUN B-O
+and CCONJ B-O
+plays VERB B-O
+a DET B-O
+critical ADJ B-O
+role NOUN B-O
+in ADP B-O
+neurodegenerative ADJ B-O
+diseases NOUN B-O
+. PUNCT B-O
+
+HDN PROPN B-AC
+, PUNCT B-O
+human NOUN B-LF
+- PUNCT I-LF
+baited VERB I-LF
+double ADJ I-LF
+net NOUN I-LF
+trap NOUN B-O
+; PUNCT B-O
+HLC PROPN B-AC
+, PUNCT B-O
+human NOUN B-O
+landing NOUN B-O
+catch NOUN B-O
+method NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+therapeutic ADJ B-O
+strategies NOUN B-O
+for ADP B-O
+RA PROPN B-AC
+have AUX B-O
+developed VERB B-O
+remarkably ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+treat VERB B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+target NOUN I-LF
+( PUNCT B-O
+T2 PROPN B-AC
+) PUNCT B-O
+strategy NOUN B-O
+described VERB B-O
+in ADP B-O
+the DET B-O
+European PROPN B-LF
+League PROPN I-LF
+Against ADP I-LF
+Rheumatism PROPN I-LF
+( PUNCT B-O
+TEULAR PROPN B-AC
+) PUNCT B-O
+recommendations NOUN B-O
+is AUX B-O
+to PART B-O
+aim VERB B-O
+for ADP B-O
+remission NOUN B-O
+or CCONJ B-O
+low ADJ B-LF
+disease NOUN I-LF
+activity NOUN I-LF
+( PUNCT B-O
+LDA PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Fluid NOUN B-LF
+- PUNCT I-LF
+attenuated VERB I-LF
+inversion NOUN I-LF
+recovery NOUN I-LF
+( PUNCT B-O
+FLAIR PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+principle ADJ B-O
+imaging NOUN B-O
+sequence NOUN B-O
+for ADP B-O
+assessment NOUN B-O
+of ADP B-O
+growth NOUN B-O
+of ADP B-O
+low ADJ B-O
+- PUNCT B-O
+grade NOUN B-O
+gliomas NOUN B-O
+[ PUNCT B-O
+4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+present ADJ B-O
+study NOUN B-O
+, PUNCT B-O
+by ADP B-O
+generating VERB B-O
+new ADJ B-O
+recombinant ADJ B-O
+chromosomes NOUN B-LF
+, PUNCT B-O
+we PRON B-O
+have AUX B-O
+been AUX B-O
+able ADJ B-O
+to PART B-O
+locate VERB B-O
+the DET B-O
+genetic ADJ B-O
+element NOUN B-O
+responsible ADJ B-O
+for ADP B-O
+Psmb9 NOUN B-O
+activity NOUN B-O
+within ADP B-O
+6.7 NUM B-O
+Mb NOUN B-O
+on ADP B-O
+Chr PROPN B-AC
+17 NUM B-O
+. PUNCT B-O
+
+We PRON B-O
+found VERB B-O
+that SCONJ B-O
+each DET B-O
+point NOUN B-O
+increase NOUN B-O
+in ADP B-O
+QFPC PROPN B-AC
+, PUNCT B-O
+including VERB B-O
+increasing VERB B-O
+quality NOUN B-O
+of ADP B-O
+counselling NOUN B-O
+, PUNCT B-O
+is AUX B-O
+associated VERB B-O
+with ADP B-O
+higher ADJ B-O
+odds NOUN B-O
+of ADP B-O
+clients NOUN B-O
+selecting VERB B-O
+an DET B-O
+intrauterine ADJ B-LF
+device NOUN I-LF
+( PUNCT B-O
+IUD PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+aRR:1.03 PROPN B-AC
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI:1.01–1.05 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+sterilization NOUN B-O
+( PUNCT B-O
+aRR:1.06 PROPN B-AC
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI:1.03–1.08 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+compared VERB B-O
+to ADP B-O
+no DET B-O
+method NOUN B-O
+selected VERB B-O
+. PUNCT B-O
+
+The DET B-O
+aim NOUN B-O
+of ADP B-O
+the DET B-O
+present ADJ B-O
+study NOUN B-O
+was AUX B-O
+to PART B-O
+investigate VERB B-O
+the DET B-O
+association NOUN B-O
+between ADP B-O
+the DET B-O
+functional ADJ B-O
+ITPA PROPN B-AC
+variants NOUN B-O
+and CCONJ B-O
+hematological ADJ B-O
+side NOUN B-O
+effects NOUN B-O
+during ADP B-O
+antiviral ADJ B-O
+therapy NOUN B-O
+with ADP B-O
+pegylated ADJ B-LF
+interferon NOUN I-LF
+( PUNCT B-O
+PegIFN PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+RBV PROPN B-AC
+. PUNCT B-O
+
+Ressing PROPN B-O
+, PUNCT B-O
+Leiden PROPN B-O
+University PROPN B-O
+Medical PROPN B-O
+Center PROPN B-O
+, PUNCT B-O
+the DET B-O
+Netherlands PROPN B-O
+[ PUNCT B-O
+35 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+were AUX B-O
+cultured VERB B-O
+in ADP B-O
+Roswell PROPN B-LF
+Park PROPN I-LF
+Memorial PROPN I-LF
+Institute PROPN I-LF
+( PUNCT B-O
+RPMI PROPN B-AC
+) PUNCT B-O
+medium NOUN B-O
+( PUNCT B-O
+Gibco PROPN B-O
+) PUNCT B-O
+supplemented VERB B-O
+with ADP B-O
+10 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+v NOUN B-O
+/ SYM B-O
+v NOUN B-O
+) PUNCT B-O
+FBS PROPN B-AC
+, PUNCT B-O
+2 NUM B-O
+mM PROPN B-O
+GlutaMAX PROPN B-O
+, PUNCT B-O
+1 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+v NOUN B-O
+/ SYM B-O
+v NOUN B-O
+) PUNCT B-O
+Pen PROPN B-O
+- PUNCT B-O
+Strep PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+0.3 NUM B-O
+mg NOUN B-O
+/ SYM B-O
+mL NOUN B-O
+hygromycin NOUN B-O
+B. NOUN B-O
+A DET B-O
+new ADJ B-O
+release NOUN B-O
+of ADP B-O
+XPDF PROPN B-AC
+( PUNCT B-O
+a DET B-LF
+PDF NOUN I-LF
+viewer NOUN I-LF
+for ADP I-LF
+X PROPN I-LF
+; PUNCT B-O
+http://www.foolabs.com/xpdf/ X B-O
+) PUNCT B-O
+eases VERB B-O
+this DET B-O
+problem NOUN B-O
+considerably ADV B-O
+( PUNCT B-O
+see VERB B-O
+Materials PROPN B-O
+and CCONJ B-O
+Methods PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+rodent NOUN B-O
+models NOUN B-O
+of ADP B-O
+chronic ADJ B-O
+inflammatory ADJ B-O
+and CCONJ B-O
+neuropathic ADJ B-O
+pain NOUN B-O
+, PUNCT B-O
+there PRON B-O
+is VERB B-O
+a DET B-O
+male NOUN B-O
+- PUNCT B-O
+specific ADJ B-O
+activation NOUN B-O
+of ADP B-O
+microglial ADJ B-O
+signaling NOUN B-O
+in ADP B-O
+the DET B-O
+spinal ADJ B-O
+cord NOUN B-O
+, PUNCT B-O
+which PRON B-O
+includes VERB B-O
+the DET B-O
+up NOUN B-O
+- PUNCT B-O
+regulation NOUN B-O
+of ADP B-O
+P2X4 NOUN B-O
+receptors NOUN B-O
+[ PUNCT B-O
+38 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+phosphorylation NOUN B-O
+of ADP B-O
+p38−mitogen NOUN B-O
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+MAPK PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+39 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+subsequent ADJ B-O
+synthesis NOUN B-O
+and CCONJ B-O
+release NOUN B-O
+of ADP B-O
+BDNF PROPN B-AC
+[ PUNCT B-O
+20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+newly ADV B-O
+evolved VERB B-O
+cell NOUN B-O
+type NOUN B-O
+is AUX B-O
+rigidly ADV B-O
+specified VERB B-O
+early ADV B-O
+in ADP B-O
+development NOUN B-O
+through ADP B-O
+the DET B-O
+activity NOUN B-O
+of ADP B-O
+localized VERB B-O
+maternal ADJ B-O
+factors NOUN B-O
+and CCONJ B-O
+deploys VERB B-O
+a DET B-O
+well ADV B-O
+- PUNCT B-O
+characterized VERB B-O
+gene NOUN B-LF
+regulatory ADJ I-LF
+network NOUN I-LF
+( PUNCT B-O
+GRN PROPN B-AC
+) PUNCT B-O
+that PRON B-O
+controls VERB B-O
+the DET B-O
+morphogenetic ADJ B-O
+behaviors NOUN B-O
+and CCONJ B-O
+biomineral NOUN B-O
+- PUNCT B-O
+forming VERB B-O
+properties NOUN B-O
+of ADP B-O
+PMCs PROPN B-AC
+[ X B-O
+1–3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Calreticulin NOUN B-LF
+( PUNCT B-O
+CRT PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+multifunctional ADJ B-O
+stress NOUN B-O
+- PUNCT B-O
+response NOUN B-O
+chaperone NOUN B-O
+residing VERB B-O
+mainly ADV B-O
+in ADP B-O
+the DET B-O
+lumen NOUN B-O
+of ADP B-O
+the DET B-O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT B-O
+ER PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+cell NOUN B-O
+with ADP B-O
+the DET B-O
+ability NOUN B-O
+to PART B-O
+control VERB B-O
+proper ADJ B-O
+protein NOUN B-O
+folding NOUN B-O
+and CCONJ B-O
+regulate VERB B-O
+cellular ADJ B-O
+adhesion NOUN B-O
+[ PUNCT B-O
+1–6 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+have AUX B-O
+previously ADV B-O
+reported VERB B-O
+that SCONJ B-O
+the DET B-O
+structure NOUN B-O
+and CCONJ B-O
+composition NOUN B-O
+of ADP B-O
+HF PROPN B-AC
+- PUNCT B-O
+released VERB B-O
+secondary ADJ B-LF
+cell NOUN I-LF
+wall NOUN I-LF
+polysaccharides NOUN I-LF
+( PUNCT B-O
+HF PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+Ba PROPN B-O
+vegetative ADJ B-O
+cells NOUN B-O
+are AUX B-O
+not PART B-O
+dependent ADJ B-O
+on ADP B-O
+plasmid NOUN B-O
+content NOUN B-O
+[ X B-O
+11 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+are AUX B-O
+specific ADJ B-O
+for ADP B-O
+Ba PROPN B-O
+and CCONJ B-O
+antigenic ADJ B-O
+[ X B-O
+12–14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+PDCD10 PROPN B-AC
+complexes NOUN B-O
+with ADP B-O
+CCM1 PROPN B-O
+( PUNCT B-O
+Krev PROPN B-LF
+/ SYM I-LF
+Rap1 PROPN I-LF
+Interacting PROPN I-LF
+Trapped PROPN I-LF
+1 NUM I-LF
+[ PUNCT B-O
+KRIT1 PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+and CCONJ B-O
+CCM2 PROPN B-O
+( PUNCT B-O
+osmosensing VERB B-LF
+scaffold NOUN I-LF
+for ADP I-LF
+mitogen NOUN I-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+kinase NOUN I-LF
+kinase-3 NOUN I-LF
+[ PUNCT B-O
+OSM PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+to PART B-O
+control VERB B-O
+the DET B-O
+onset NOUN B-O
+of ADP B-O
+a DET B-O
+detrimental ADJ B-O
+disease NOUN B-O
+named VERB B-O
+CCM PROPN B-AC
+. PUNCT B-O
+
+CCM PROPN B-AC
+is AUX B-O
+characterized VERB B-O
+by ADP B-O
+vascular ADJ B-O
+lesions NOUN B-O
+in ADP B-O
+the DET B-O
+central ADJ B-O
+nervous ADJ B-O
+system NOUN B-O
+[ PUNCT B-O
+14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+Simes PROPN B-O
+multiple ADJ B-O
+- NOUN B-O
+test NOUN B-O
+procedure NOUN B-O
+was AUX B-O
+used VERB B-O
+for ADP B-O
+controlling VERB B-O
+the DET B-O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+( PUNCT B-O
+FDR PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+SNP PROPN B-AC
+rs848 NUM B-O
+in ADP B-O
+the DET B-O
+IL13 NUM B-O
+gene NOUN B-O
+region NOUN B-O
+( PUNCT B-O
+IL5 NOUN B-O
+/ SYM B-O
+RAD50 NOUN B-O
+/ SYM B-O
+IL13 NUM B-O
+/ SYM B-O
+IL4 NUM B-O
+) PUNCT B-O
+was AUX B-O
+associated VERB B-O
+with ADP B-O
+STS PROPN B-AC
+( PUNCT B-O
+TG NOUN B-O
+/ SYM B-O
+GG NOUN B-O
+vs ADP B-O
+TT PROPN B-O
+genotype NOUN B-O
+: PUNCT B-O
+uncorrected ADJ B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+= SYM B-O
+0.00006 NUM B-O
+, PUNCT B-O
+FDR PROPN B-AC
+- NOUN B-O
+corrected VERB B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+= SYM B-O
+0.04 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+whereas SCONJ B-O
+rs20541 NOUN B-O
+in ADP B-O
+the DET B-O
+same ADJ B-O
+gene NOUN B-O
+region NOUN B-O
+, PUNCT B-O
+in ADP B-O
+linkage NOUN B-O
+disequilibrium NOUN B-O
+with ADP B-O
+rs848 NUM B-O
+( PUNCT B-O
+r2 NOUN B-O
+= SYM B-O
+0.94 NUM B-O
+) PUNCT B-O
+in ADP B-O
+our PRON B-O
+sample NOUN B-O
+, PUNCT B-O
+did AUX B-O
+not PART B-O
+reach VERB B-O
+the DET B-O
+statistical ADJ B-O
+significance NOUN B-O
+after ADP B-O
+adjusting VERB B-O
+for ADP B-O
+multiple ADJ B-O
+testing NOUN B-O
+( PUNCT B-O
+TC NOUN B-O
+/ SYM B-O
+CC NOUN B-O
+vs ADP B-O
+TT PROPN B-O
+: PUNCT B-O
+uncorrected ADJ B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+= SYM B-O
+0.0003 NUM B-O
+, PUNCT B-O
+FDR PROPN B-AC
+- NOUN B-O
+corrected VERB B-O
+p NOUN B-O
+- NOUN B-O
+value NOUN B-O
+= SYM B-O
+0.09 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Eukaryotic ADJ B-O
+genomes NOUN B-O
+contain VERB B-O
+large ADJ B-O
+quantities NOUN B-O
+of ADP B-O
+transposable ADJ B-LF
+elements NOUN I-LF
+( PUNCT B-O
+TEs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+short ADJ B-O
+self NOUN B-O
+- PUNCT B-O
+replicating VERB B-O
+DNA NOUN B-O
+sequences NOUN B-O
+that PRON B-O
+can AUX B-O
+move VERB B-O
+within ADP B-O
+the DET B-O
+genome NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+criteria NOUN B-O
+aPL PROPN B-AC
+( PUNCT B-O
+aCL PROPN B-AC
+and CCONJ B-O
+aβ2-GPI PROPN B-AC
+IgG NOUN B-O
+and CCONJ B-O
+IgM NOUN B-O
+) PUNCT B-O
+were AUX B-O
+determined VERB B-O
+with SCONJ B-O
+four NUM B-O
+well ADV B-O
+- PUNCT B-O
+established VERB B-O
+immunoassay NOUN B-O
+systems NOUN B-O
+in ADP B-O
+all PRON B-O
+included VERB B-O
+sera NOUN B-O
+: PUNCT B-O
+ALE PROPN B-AC
+, PUNCT B-O
+ACU PROPN B-AC
+, PUNCT B-O
+UniCAP PROPN B-LF
+250 NUM I-LF
+( PUNCT B-O
+UNI PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+Thermo PROPN B-O
+Fisher PROPN B-O
+Scientific PROPN B-O
+( PUNCT B-O
+Freiburg PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+AESKULISA PROPN B-LF
+( PUNCT B-O
+AES PROPN B-AC
+) PUNCT B-O
+from ADP B-O
+Aesku.diagnostics PROPN B-O
+( PUNCT B-O
+Wendelsheim PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+First ADV B-O
+, PUNCT B-O
+during ADP B-O
+data NOUN B-O
+preprocessing NOUN B-O
+, PUNCT B-O
+we PRON B-O
+removed VERB B-O
+oculomotor NOUN B-O
+artefacts NOUN B-O
+via ADP B-O
+independent ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+( PUNCT B-O
+ICA PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+see VERB B-O
+S1 PROPN B-O
+Text NOUN B-O
+) PUNCT B-O
+; PUNCT B-O
+second X B-O
+, PUNCT B-O
+we PRON B-O
+have AUX B-O
+only ADV B-O
+reported VERB B-O
+data NOUN B-O
+in ADP B-O
+this DET B-O
+paper NOUN B-O
+from ADP B-O
+two NUM B-O
+channels NOUN B-O
+near ADP B-O
+the DET B-O
+vertex NOUN B-O
+— PUNCT B-O
+C3 NOUN B-O
+and CCONJ B-O
+C4 NOUN B-O
+, PUNCT B-O
+which PRON B-O
+show VERB B-O
+the DET B-O
+least ADJ B-O
+contamination NOUN B-O
+by ADP B-O
+muscle NOUN B-O
+and CCONJ B-O
+motion NOUN B-O
+artefacts NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+See VERB B-O
+S5 PROPN B-O
+and CCONJ B-O
+S6 PROPN B-O
+Figs NOUN B-O
+for ADP B-O
+comparable ADJ B-O
+plots NOUN B-O
+of ADP B-O
+anterior ADJ B-O
+and CCONJ B-O
+posterior ADJ B-O
+midline NOUN B-O
+groups NOUN B-O
+. PUNCT B-O
+
+) PUNCT B-O
+Third X B-O
+, PUNCT B-O
+the DET B-O
+cross ADJ B-O
+- NOUN B-O
+correlation NOUN B-O
+analysis NOUN B-O
+across ADP B-O
+different ADJ B-O
+frequencies NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+2A NUM B-O
+) PUNCT B-O
+indicated VERB B-O
+that SCONJ B-O
+relationships NOUN B-O
+were AUX B-O
+specific ADJ B-O
+to ADP B-O
+the DET B-O
+theta NOUN B-O
+band NOUN B-O
+. PUNCT B-O
+
+Prostate ADJ B-LF
+- PUNCT I-LF
+Specific ADJ I-LF
+Antigen NOUN I-LF
+( PUNCT I-LF
+PSA PROPN I-LF
+In ADP B-O
+principle NOUN B-O
+, PUNCT B-O
+it PRON B-O
+can AUX B-O
+occur VERB B-O
+via ADP B-O
+any DET B-O
+1 NUM B-O
+of ADP B-O
+3 NUM B-O
+mechanisms NOUN B-O
+of ADP B-O
+homologous ADJ B-LF
+recombination NOUN I-LF
+( PUNCT B-O
+HR PROPN B-AC
+): PUNCT B-O
+canonical ADJ B-O
+DSB PROPN B-LF
+repair NOUN I-LF
+DSB PROPN B-AC
+( PUNCT B-O
+DSBR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+synthesis NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+strand NOUN I-LF
+annealing NOUN I-LF
+( PUNCT B-O
+SDSA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+break NOUN B-LF
+- PUNCT I-LF
+induced VERB I-LF
+replication NOUN I-LF
+( PUNCT B-O
+BIR PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+reviewed VERB B-O
+in ADP B-O
+[ X B-O
+21,22 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Coverage NOUN B-O
+estimates NOUN B-O
+are AUX B-O
+generally ADV B-O
+obtained VERB B-O
+from ADP B-O
+routine ADJ B-O
+population NOUN B-O
+- PUNCT B-O
+based VERB B-O
+household NOUN B-O
+surveys NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+the DET B-O
+Demographic PROPN B-O
+and CCONJ B-O
+Health PROPN B-O
+Surveys PROPN B-O
+( PUNCT B-O
+DHS PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+Multiple PROPN B-LF
+Indicator PROPN I-LF
+Cluster PROPN I-LF
+Surveys PROPN I-LF
+( PUNCT B-O
+MICS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+primarily ADV B-O
+through ADP B-O
+self NOUN B-O
+- PUNCT B-O
+reporting NOUN B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+named VERB B-O
+these PRON B-O
+long ADJ B-O
+expressed VERB B-LF
+noncoding NOUN I-LF
+regions NOUN I-LF
+( PUNCT B-O
+ENORs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+clinical ADJ B-O
+implication NOUN B-O
+of ADP B-O
+AF PROPN B-AC
+is AUX B-O
+that SCONJ B-O
+it PRON B-O
+is AUX B-O
+associated VERB B-O
+with ADP B-O
+an DET B-O
+increased VERB B-O
+risk NOUN B-O
+of ADP B-O
+stroke NOUN B-O
+, PUNCT B-O
+heart NOUN B-LF
+failure NOUN I-LF
+( PUNCT B-O
+HF PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+( PUNCT B-O
+MI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+death NOUN B-O
+[ X B-O
+2,4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+primary ADJ B-O
+endpoint NOUN B-O
+was AUX B-O
+clinical ADJ B-O
+benefit NOUN B-O
+( PUNCT B-O
+defined VERB B-O
+as ADP B-O
+stable ADJ B-LF
+disease NOUN I-LF
+[ PUNCT B-O
+SD PROPN B-AC
+] PUNCT B-O
+for ADP B-O
+≥6 NUM B-O
+mo NOUN B-O
+, PUNCT B-O
+partial ADJ B-LF
+response NOUN I-LF
+[ PUNCT B-O
+PR PROPN B-AC
+] PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+complete ADJ B-LF
+response NOUN I-LF
+[ PUNCT B-O
+CR PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+True ADJ B-LF
+skill NOUN I-LF
+statistic NOUN I-LF
+( PUNCT B-O
+TSS PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+used VERB B-O
+as ADP B-O
+a DET B-O
+measure NOUN B-O
+of ADP B-O
+the DET B-O
+model NOUN B-O
+quality NOUN B-O
+, PUNCT B-O
+since SCONJ B-O
+it PRON B-O
+was AUX B-O
+a DET B-O
+default ADJ B-O
+measure NOUN B-O
+in ADP B-O
+BIOMOD PROPN B-O
+2.1.37 NUM B-O
+[ PUNCT B-O
+52 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+971 NUM B-O
+- PUNCT B-O
+bp PROPN B-AC
+probe NOUN B-O
+revealed VERB B-O
+DNA NOUN B-O
+rearrangements NOUN B-O
+, PUNCT B-O
+refining VERB B-O
+the DET B-O
+breakpoint NOUN B-O
+to ADP B-O
+a DET B-O
+4.7 NUM B-O
+- PUNCT B-O
+kilobase NOUN B-LF
+( PUNCT B-O
+kb PROPN B-AC
+) PUNCT B-O
+interval NOUN B-O
+on ADP B-O
+the DET B-O
+Celera PROPN B-O
+scaffold NOUN B-O
+sequence NOUN B-O
+or CCONJ B-O
+a DET B-O
+4.0 NUM B-O
+- PUNCT B-O
+kb PROPN B-AC
+interval NOUN B-O
+corresponding VERB B-O
+to ADP B-O
+nucleotides NOUN B-O
+57269–61233 NUM B-O
+of ADP B-O
+BAC PROPN B-AC
+AC117479 NUM B-O
+( PUNCT B-O
+Figure NOUN B-O
+1B NUM B-O
+and CCONJ B-O
+1D NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Surprisingly ADV B-O
+, PUNCT B-O
+the DET B-O
+translocation NOUN B-O
+breakpoint NOUN B-O
+localized VERB B-O
+within ADP B-O
+the DET B-O
+ortholog NOUN B-O
+of ADP B-O
+the DET B-O
+Drosophila PROPN B-O
+roundabout NOUN B-O
+( PUNCT B-O
+robo NOUN B-O
+) PUNCT B-O
+gene NOUN B-O
+, PUNCT B-O
+ROBO1 NOUN B-O
+, PUNCT B-O
+alternatively ADV B-O
+spliced VERB B-O
+and CCONJ B-O
+also ADV B-O
+named VERB B-O
+DUTT1 PROPN B-O
+( PUNCT B-O
+Deleted VERB B-O
+in ADP B-O
+U PROPN B-O
+Twenty PROPN B-O
+Twenty PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+disrupts VERB B-O
+ROBO1 NOUN B-O
+between ADP B-O
+exons NOUN B-O
+1 NUM B-O
+and CCONJ B-O
+2 NUM B-O
+. PUNCT B-O
+
+Known VERB B-O
+risk NOUN B-O
+factors NOUN B-O
+for ADP B-O
+mild ADJ B-O
+CI PROPN B-AC
+include VERB B-O
+increased VERB B-O
+age NOUN B-O
+and CCONJ B-O
+genetic ADJ B-O
+susceptibility NOUN B-O
+[ X B-O
+1 NUM B-O
+, PUNCT B-O
+17 NUM B-O
+] X B-O
+while SCONJ B-O
+cardiovascular ADJ B-O
+disease NOUN B-O
+( PUNCT B-O
+high ADJ B-O
+blood NOUN B-O
+pressure NOUN B-O
+and CCONJ B-O
+stroke NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+diabetes NOUN B-O
+, PUNCT B-O
+depression NOUN B-O
+/ SYM B-O
+anxiety NOUN B-O
+, PUNCT B-O
+tobacco NOUN B-O
+smoking NOUN B-O
+and CCONJ B-O
+social ADJ B-O
+factors NOUN B-O
+( PUNCT B-O
+e.g. X B-O
+, PUNCT B-O
+lack NOUN B-O
+of ADP B-O
+relationships NOUN B-O
+with ADP B-O
+others NOUN B-O
+and CCONJ B-O
+a DET B-O
+community NOUN B-O
+, PUNCT B-O
+lack NOUN B-O
+of ADP B-O
+physical ADJ B-O
+activity NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+low ADJ B-O
+socio ADJ B-LF
+- ADJ I-LF
+economic ADJ I-LF
+status NOUN I-LF
+( PUNCT B-O
+SES PROPN B-AC
+) PUNCT B-O
+) PUNCT B-O
+[ X B-O
+1 NUM B-O
+, PUNCT B-O
+17 NUM B-O
+, PUNCT B-O
+18 NUM B-O
+] X B-O
+are AUX B-O
+reported VERB B-O
+as ADP B-O
+possible ADJ B-O
+risk NOUN B-O
+factors NOUN B-O
+. PUNCT B-O
+
+DN PROPN B-AC
+, PUNCT B-O
+dominant NOUN B-LF
+- PUNCT I-LF
+negative ADJ I-LF
+; PUNCT B-O
+EC PROPN B-AC
+, PUNCT B-O
+endothelial ADJ B-LF
+cell NOUN I-LF
+; PUNCT B-O
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+hpf PROPN B-AC
+, PUNCT B-O
+hours NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+; PUNCT B-O
+HS PROPN B-AC
+, PUNCT B-O
+heat NOUN B-LF
+shock NOUN I-LF
+; PUNCT B-O
+HSPC PROPN B-AC
+, PUNCT B-O
+hematopoietic ADJ B-LF
+stem NOUN I-LF
+and CCONJ I-LF
+progenitor NOUN I-LF
+cell NOUN I-LF
+; PUNCT B-O
+NICD PROPN B-AC
+, PUNCT B-O
+Notch PROPN B-LF
+intracellular ADJ I-LF
+domain NOUN I-LF
+; PUNCT B-O
+n.s NOUN B-O
+. PUNCT B-O
+
+, PUNCT B-O
+nonsignificant ADJ B-O
+; PUNCT B-O
+qRT PROPN B-AC
+, PUNCT B-O
+quantitative ADJ B-LF
+reverse ADJ I-LF
+- PUNCT I-LF
+transcription ADJ I-LF
+PCR NOUN I-LF
+; PUNCT B-O
+WB PROPN B-O
+, PUNCT B-O
+western ADJ B-O
+blot NOUN B-O
+; PUNCT B-O
+-PCRWISH PROPN B-AC
+, PUNCT B-O
+whole ADJ B-LF
+- PUNCT I-LF
+mount NOUN I-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+When SCONJ B-O
+we PRON B-O
+assessed VERB B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+inflammation NOUN B-O
+in ADP B-O
+the DET B-O
+CNS PROPN B-AC
+of ADP B-O
+Nlrx1−/− PROPN B-O
+2D2 PROPN B-O
+spEAE PROPN B-AC
+mice NOUN B-O
+, PUNCT B-O
+we PRON B-O
+found VERB B-O
+that SCONJ B-O
+the DET B-O
+lack NOUN B-O
+of ADP B-O
+NLRX1 PROPN B-AC
+did AUX B-O
+not PART B-O
+affect VERB B-O
+the DET B-O
+expression NOUN B-O
+of ADP B-O
+glial ADJ B-LF
+fibrillary NOUN I-LF
+acidic ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+GFAP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+ionized VERB B-LF
+calcium NOUN I-LF
+binding VERB I-LF
+adaptor NOUN I-LF
+molecule NOUN I-LF
+1(Iba1 PROPN I-LF
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+myelin NOUN B-LF
+basic ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+MBP PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+spinal ADJ B-O
+cords NOUN B-O
+of ADP B-O
+healthy ADJ B-O
+Nlrx1−/− PROPN B-O
+2D2 PROPN B-O
+mice NOUN B-O
+( PUNCT B-O
+S1A PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Our PRON B-O
+method NOUN B-O
+was AUX B-O
+highly ADV B-O
+predictive ADJ B-O
+of ADP B-O
+transcription NOUN B-LF
+start NOUN I-LF
+sites NOUN I-LF
+( PUNCT B-O
+TSSs PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+S. PROPN B-O
+cerevisiae NOUN B-O
+[ X B-O
+50]—the X B-O
+NFR PROPN B-O
+boundary NOUN B-O
+closest ADJ B-O
+to PART B-O
+the DET B-O
+5′ NUM B-O
+end NOUN B-O
+of ADP B-O
+the DET B-O
+gene NOUN B-O
+was AUX B-O
+able ADJ B-O
+to PART B-O
+predict VERB B-O
+84 NUM B-O
+% NOUN B-O
+of ADP B-O
+TSSs PROPN B-AC
+within ADP B-O
+50 NUM B-O
+bp NOUN B-O
+. PUNCT B-O
+
+Several ADJ B-O
+lines NOUN B-O
+of ADP B-O
+evidence NOUN B-O
+suggest VERB B-O
+that SCONJ B-O
+histone NOUN B-O
+variants NOUN B-O
+and CCONJ B-O
+their PRON B-O
+covalent ADJ B-O
+post ADJ B-LF
+- ADJ I-LF
+translational ADJ I-LF
+modifications NOUN I-LF
+( PUNCT B-O
+PTMs PROPN B-AC
+) PUNCT B-O
+play VERB B-O
+a DET B-O
+key ADJ B-O
+role NOUN B-O
+in ADP B-O
+developmental ADJ B-O
+processes NOUN B-O
+such ADJ B-O
+as ADP B-O
+the DET B-O
+initiation NOUN B-O
+and CCONJ B-O
+maintenance NOUN B-O
+of ADP B-O
+pericentric ADJ B-O
+heterochromatin NOUN B-O
+, PUNCT B-O
+X NOUN B-O
+chromosome NOUN B-O
+inactivation NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+germ NOUN B-O
+cell NOUN B-O
+differentiation NOUN B-O
+[ PUNCT B-O
+4 NUM B-O
+, PUNCT B-O
+11 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Regarding VERB B-O
+the DET B-O
+biological ADJ B-O
+aspect NOUN B-O
+, PUNCT B-O
+carbon NOUN B-O
+ion NOUN B-O
+beams NOUN B-O
+have VERB B-O
+an DET B-O
+estimated VERB B-O
+2–3 NUM B-O
+- NOUN B-O
+fold ADJ B-O
+higher ADJ B-O
+relative ADJ B-LF
+biological ADJ I-LF
+effectiveness NOUN I-LF
+( PUNCT B-O
+RBE PROPN B-AC
+) PUNCT B-O
+than ADP B-O
+X NOUN B-O
+- NOUN B-O
+rays NOUN B-O
+[ PUNCT B-O
+8 NUM B-O
+, PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+order NOUN B-O
+to PART B-O
+determine VERB B-O
+the DET B-O
+mechanical ADJ B-O
+properties NOUN B-O
+of ADP B-O
+the DET B-O
+bone NOUN B-O
+material NOUN B-O
+, PUNCT B-O
+the DET B-O
+fourth ADJ B-O
+caudal ADJ B-O
+vertebrae NOUN B-O
+of ADP B-O
+6 NUM B-O
+medaka NOUN B-O
+( PUNCT B-O
+3 NUM B-O
+controls NOUN B-O
+and CCONJ B-O
+3 NUM B-O
+swim NOUN B-O
+- PUNCT B-O
+trained VERB B-O
+fish NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+6 NUM B-O
+zebrafish NOUN B-O
+( PUNCT B-O
+3 NUM B-O
+controls NOUN B-O
+and CCONJ B-O
+3 NUM B-O
+swim NOUN B-O
+- PUNCT B-O
+trained VERB B-O
+fish NOUN B-O
+) PUNCT B-O
+were AUX B-O
+dehydrated VERB B-O
+with ADP B-O
+increasing VERB B-O
+concentrations NOUN B-O
+of ADP B-O
+ethanol NOUN B-O
+and CCONJ B-O
+embedded VERB B-O
+for ADP B-O
+8 NUM B-O
+hours NOUN B-O
+in ADP B-O
+polymethylmethacrylate NOUN B-LF
+( PUNCT B-O
+PMMA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+was AUX B-O
+polymerized VERB B-O
+in ADP B-O
+an DET B-O
+oven NOUN B-O
+at ADP B-O
+60 NUM B-O
+° NOUN B-O
+C NOUN B-O
+. PUNCT B-O
+
+As SCONJ B-O
+earlier ADV B-O
+reported VERB B-O
+, PUNCT B-O
+Ace PROPN B-AC
+protein NOUN B-O
+had AUX B-O
+been AUX B-O
+modelled VERB B-O
+using VERB B-O
+a DET B-O
+template NOUN B-O
+structure NOUN B-O
+, PUNCT B-O
+zhaoermiatoxin NOUN B-O
+from ADP B-O
+Zhaoermia PROPN B-O
+mangshanensis NOUN B-O
+[ PUNCT B-O
+Protein PROPN B-LF
+Data PROPN I-LF
+Bank PROPN I-LF
+( PUNCT B-O
+PDB PROPN B-AC
+) NOUN B-O
+entry NOUN B-O
+2PH4 NOUN B-O
+] PUNCT B-O
+, PUNCT B-O
+a DET B-O
+dimeric ADJ B-O
+toxin NOUN B-O
+which PRON B-O
+showed VERB B-O
+reasonable ADJ B-O
+sequence NOUN B-O
+similarity NOUN B-O
+( PUNCT B-O
+45 NUM B-O
+% NOUN B-O
+) NOUN B-O
+with ADP B-O
+the DET B-O
+target NOUN B-O
+[ PUNCT B-O
+7 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Both DET B-O
+trials NOUN B-O
+recruited VERB B-O
+postally ADV B-O
+from ADP B-O
+primary ADJ B-O
+care NOUN B-O
+and CCONJ B-O
+delivered VERB B-O
+12 NUM B-O
+- PUNCT B-O
+week NOUN B-O
+pedometer NOUN B-O
+- PUNCT B-O
+based VERB B-O
+walking NOUN B-O
+interventions NOUN B-O
+incorporating VERB B-O
+behaviour NOUN B-LF
+change NOUN I-LF
+techniques NOUN I-LF
+( PUNCT B-O
+BCTs PROPN B-AC
+) PUNCT B-O
+through ADP B-O
+dedicated ADJ B-O
+practice NOUN B-O
+nurse NOUN B-O
+PA PROPN B-AC
+consultations NOUN B-O
+( PUNCT B-O
+3 NUM B-O
+in ADP B-O
+PACE PROPN B-AC
+, PUNCT B-O
+4 NUM B-O
+in ADP B-O
+-UPPACE PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+by ADP B-O
+post NOUN B-O
+( PUNCT B-O
+-LiftPACE PROPN B-AC
+only ADV B-O
+) PUNCT B-O
+. PUNCT B-O
+
+DAS28-ESR PROPN B-AC
+, PUNCT B-O
+Disease PROPN B-LF
+Activity PROPN I-LF
+Score–28 NUM I-LF
+with ADP I-LF
+erythrocyte NOUN I-LF
+sedimentation NOUN I-LF
+rate NOUN I-LF
+; PUNCT B-O
+Early ADJ B-O
+, PUNCT B-O
+early ADJ B-O
+treatment NOUN B-O
+; PUNCT B-O
+HAQ PROPN B-AC
+, PUNCT B-O
+Health PROPN B-LF
+Assessment PROPN I-LF
+Questionnaire NOUN I-LF
+; PUNCT B-O
+NSAID PROPN B-O
+, PUNCT B-O
+nonsteroidal ADJ B-O
+anti ADJ B-O
+- PUNCT B-O
+inflammatory ADJ B-O
+drug NOUN B-O
+; PUNCT B-O
+MTX PROPN B-O
+, PUNCT B-O
+methotrexate NOUN B-O
+; PUNCT B-O
+noMTX PROPN B-O
+, PUNCT B-O
+no DET B-O
+methotrexate NOUN B-O
+; PUNCT B-O
+RA PROPN B-AC
+, PUNCT B-O
+rheumatoid ADJ B-LF
+arthritis NOUN I-LF
+; PUNCT B-O
+SDFR PROPN B-AC
+, PUNCT B-O
+sustained VERB B-LF
+DMARD NOUN I-LF
+- PUNCT I-LF
+DMARD PROPN B-AC
+free ADJ I-LF
+remission NOUN I-LF
+; PUNCT B-O
+T2 PROPN B-O
+T PROPN B-O
+, PUNCT B-O
+treat VERB B-O
+- PUNCT B-O
+to ADP B-O
+- PUNCT B-O
+target NOUN B-O
+. PUNCT B-O
+
+Behavioral ADJ B-O
+factors NOUN B-O
+defined VERB B-O
+by ADP B-O
+the DET B-O
+Kenya PROPN B-O
+PrEP PROPN B-AC
+guidelines NOUN B-O
+to PART B-O
+indicate VERB B-O
+a DET B-O
+substantial ADJ B-O
+ongoing ADJ B-O
+risk NOUN B-O
+of ADP B-O
+acquiring VERB B-O
+HIV PROPN B-O
+include VERB B-O
+the DET B-O
+following VERB B-O
+: PUNCT B-O
+( PUNCT B-O
+a DET B-O
+) PUNCT B-O
+inconsistent ADJ B-O
+or CCONJ B-O
+no PRON B-O
+condom NOUN B-O
+use NOUN B-O
+in ADP B-O
+the DET B-O
+last ADJ B-O
+6 NUM B-O
+months NOUN B-O
+; PUNCT B-O
+( PUNCT B-O
+b X B-O
+) PUNCT B-O
+having VERB B-O
+a DET B-O
+high ADJ B-O
+- PUNCT B-O
+risk NOUN B-O
+sex NOUN B-O
+partner(s NOUN B-O
+) PUNCT B-O
+of ADP B-O
+unknown ADJ B-O
+HIV PROPN B-O
+status NOUN B-O
+; PUNCT B-O
+( PUNCT B-O
+c X B-O
+) PUNCT B-O
+engaging VERB B-O
+in ADP B-O
+transactional ADJ B-O
+sex NOUN B-O
+; PUNCT B-O
+( PUNCT B-O
+d X B-O
+) PUNCT B-O
+history NOUN B-O
+of ADP B-O
+ongoing ADJ B-O
+intimate ADJ B-LF
+partner NOUN I-LF
+violence NOUN I-LF
+( PUNCT B-O
+IPV PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+gender NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+violence NOUN I-LF
+( PUNCT B-O
+GBV PROPN B-AC
+) PUNCT B-O
+; PUNCT B-O
+( PUNCT B-O
+e X B-O
+) PUNCT B-O
+recent ADJ B-O
+bacterial ADJ B-O
+STIs PROPN B-AC
+, PUNCT B-O
+self NOUN B-O
+- PUNCT B-O
+reported VERB B-O
+or CCONJ B-O
+etiologically ADV B-O
+diagnosed VERB B-O
+; PUNCT B-O
+( PUNCT B-O
+f X B-O
+) PUNCT B-O
+recurrent ADJ B-O
+use NOUN B-O
+of ADP B-O
+postexposure ADJ B-O
+prophylaxis NOUN B-O
+; PUNCT B-O
+( PUNCT B-O
+g X B-O
+) PUNCT B-O
+recurrent ADJ B-O
+sex NOUN B-O
+under ADP B-O
+the DET B-O
+influence NOUN B-O
+of ADP B-O
+alcohol NOUN B-O
+and/or CCONJ B-O
+recreational ADJ B-O
+drugs NOUN B-O
+; PUNCT B-O
+( PUNCT B-O
+h X B-O
+) PUNCT B-O
+injection NOUN B-O
+drug NOUN B-O
+use NOUN B-O
+with ADP B-O
+shared VERB B-O
+needles NOUN B-O
+and/or CCONJ B-O
+syringes NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+( PUNCT B-O
+i X B-O
+) PUNCT B-O
+having VERB B-O
+an DET B-O
+HIV PROPN B-O
+- PUNCT B-O
+positive ADJ B-O
+partner NOUN B-O
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+One NUM B-O
+recent ADJ B-O
+study NOUN B-O
+found VERB B-O
+that SCONJ B-O
+healthy ADJ B-O
+lifestyle NOUN B-O
+profiles NOUN B-O
+were AUX B-O
+associated VERB B-O
+with ADP B-O
+lower ADJ B-O
+risks NOUN B-O
+of ADP B-O
+dementia NOUN B-O
+only ADV B-O
+among ADP B-O
+apolipoprotein NOUN B-LF
+E PROPN I-LF
+( PUNCT B-O
+APOE PROPN B-AC
+) PUNCT B-O
+ε4 NUM B-O
+noncarriers NOUN B-O
+, PUNCT B-O
+but CCONJ B-O
+not PART B-O
+among ADP B-O
+carriers NOUN B-O
+. PUNCT B-O
+
+HIV PROPN B-AC
+/ SYM B-O
+AIDS PROPN B-AC
+predisposes VERB B-O
+for ADP B-O
+Mycobacterium NOUN B-O
+tuberculosis NOUN B-LF
+( PUNCT B-O
+MTB NOUN B-O
+) PUNCT B-O
+infection NOUN B-O
+and CCONJ B-O
+increases VERB B-O
+the DET B-O
+rate NOUN B-O
+of ADP B-O
+recurrent ADJ B-O
+TB PROPN B-AC
+as ADP B-O
+well ADV B-O
+as ADP B-O
+of ADP B-O
+rapid ADJ B-O
+progress NOUN B-O
+to ADP B-O
+active ADJ B-O
+TB PROPN B-AC
+among ADP B-O
+individuals NOUN B-O
+with ADP B-O
+recently ADV B-O
+acquired VERB B-O
+infection NOUN B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+These DET B-O
+properties NOUN B-O
+of ADP B-O
+the DET B-O
+IVs PROPN B-AC
+are AUX B-O
+discussed VERB B-O
+in ADP B-O
+more ADJ B-O
+detail NOUN B-O
+in ADP B-O
+the DET B-O
+section NOUN B-O
+, PUNCT B-O
+Assumptions NOUN B-O
+and CCONJ B-O
+Limitations NOUN B-O
+of ADP B-O
+Instrumental ADJ B-LF
+Variables NOUN I-LF
+in ADP B-O
+Text PROPN B-O
+S1 NUM B-O
+. PUNCT B-O
+
+CDS PROPN B-AC
+, PUNCT B-O
+coding NOUN B-LF
+sequence NOUN I-LF
+; PUNCT B-O
+TE PROPN B-AC
+, PUNCT B-O
+transposable ADJ B-LF
+element NOUN I-LF
+. PUNCT B-O
+
+On ADP B-O
+exposure NOUN B-O
+to ADP B-O
+stress NOUN B-O
+condition NOUN B-O
+these DET B-O
+defence NOUN B-O
+systems NOUN B-O
+are AUX B-O
+activated VERB B-O
+both CCONJ B-O
+enzymatically ADV B-O
+( PUNCT B-O
+ascorbate NOUN B-O
+peroxidase NOUN B-O
+, PUNCT B-O
+catalase NOUN B-O
+, PUNCT B-O
+superoxide NOUN B-O
+dismutase NOUN B-O
+and CCONJ B-O
+peroxidase NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+non ADV B-O
+- ADV B-O
+enzymatically ADV B-O
+( PUNCT B-O
+secondary ADJ B-O
+metabolites NOUN B-O
+) PUNCT B-O
+scavenging VERB B-O
+the DET B-O
+reactive ADJ B-LF
+oxygen NOUN I-LF
+species NOUN I-LF
+( PUNCT B-O
+ROS PROPN B-AC
+) PUNCT B-O
+formed VERB B-O
+as ADP B-O
+result NOUN B-O
+of ADP B-O
+stress NOUN B-O
+condition NOUN B-O
+[ PUNCT B-O
+76 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+EV PROPN B-AC
+, PUNCT B-O
+extracellular ADJ B-LF
+vesicle NOUN I-LF
+; PUNCT B-O
+LPS PROPN B-AC
+, PUNCT B-O
+lipopolysaccharide NOUN B-LF
+. PUNCT B-O
+
+Pseudohyphal ADJ B-O
+growth NOUN B-O
+requires VERB B-O
+the DET B-O
+initiation NOUN B-O
+of ADP B-O
+polarised ADJ B-O
+growth NOUN B-O
+for ADP B-O
+cellular ADJ B-O
+elongation NOUN B-O
+and CCONJ B-O
+is AUX B-O
+under ADP B-O
+the DET B-O
+control NOUN B-O
+of ADP B-O
+two NUM B-O
+signaling NOUN B-O
+pathways NOUN B-O
+: PUNCT B-O
+a DET B-O
+cyclic ADJ B-LF
+adenosine NOUN I-LF
+monophosphate NOUN I-LF
+( PUNCT B-O
+kinase NOUN I-LF
+cAMP)/protein PROPN B-AC
+A NOUN I-LF
+( PUNCT B-O
+PKA PROPN B-AC
+) PUNCT B-O
+pathway NOUN B-O
+and CCONJ B-O
+a DET B-O
+mitogen NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+MAPK PROPN B-AC
+) PUNCT B-O
+cascade NOUN B-O
+. PUNCT B-O
+
+Half NOUN B-O
+of ADP B-O
+the DET B-O
+digest NOUN B-O
+( PUNCT B-O
+500 NUM B-O
+µl NOUN B-O
+) PUNCT B-O
+was AUX B-O
+loaded VERB B-O
+on ADP B-O
+a DET B-O
+strong ADJ B-LF
+anion NOUN I-LF
+exchange NOUN I-LF
+( PUNCT B-O
+SAX PROPN B-AC
+) PUNCT B-O
+column NOUN B-O
+( PUNCT B-O
+SAX PROPN B-AC
+- PUNCT B-O
+Zirchrom PROPN B-O
+2.1 NUM B-O
+mm NOUN B-O
+I.D.×150 NOUN B-O
+mm NOUN B-O
+length NOUN B-O
+; PUNCT B-O
+3 NUM B-O
+µm NOUN B-O
+particles NOUN B-O
+, PUNCT B-O
+ZirChrom PROPN B-O
+Separations PROPN B-O
+, PUNCT B-O
+Anoka PROPN B-O
+, PUNCT B-O
+MN PROPN B-O
+, PUNCT B-O
+USA PROPN B-O
+) PUNCT B-O
+after ADP B-O
+which PRON B-O
+a DET B-O
+binary ADJ B-O
+solvent NOUN B-O
+gradient NOUN B-O
+was AUX B-O
+applied VERB B-O
+to ADP B-O
+fractionate NOUN B-O
+peptides NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+host NOUN B-O
+- PUNCT B-O
+encoded VERB B-O
+glycophosphatidylinositol NOUN B-O
+anchored VERB B-O
+prion NOUN B-O
+protein NOUN B-O
+, PUNCT B-O
+PrPC PROPN B-O
+, PUNCT B-O
+is AUX B-O
+essential ADJ B-O
+for ADP B-O
+the DET B-O
+development NOUN B-O
+of ADP B-O
+TSE PROPN B-AC
+disease NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+a DET B-O
+common ADJ B-O
+feature NOUN B-O
+of ADP B-O
+these DET B-O
+diseases NOUN B-O
+is AUX B-O
+the DET B-O
+accumulation NOUN B-O
+of ADP B-O
+PrPSc PROPN B-O
+in ADP B-O
+the DET B-O
+brain NOUN B-O
+, PUNCT B-O
+an DET B-O
+abnormal ADJ B-O
+form NOUN B-O
+of ADP B-O
+PrPC PROPN B-O
+, PUNCT B-O
+which PRON B-O
+displays VERB B-O
+partial ADJ B-O
+resistance NOUN B-O
+to ADP B-O
+proteinase NOUN B-LF
+K PROPN I-LF
+( PUNCT B-O
+PK PROPN B-AC
+) PUNCT B-O
+digestion NOUN B-O
+. PUNCT B-O
+
+Lung NOUN B-O
+adenocarcinomas NOUN B-O
+from ADP B-O
+patients NOUN B-O
+who PRON B-O
+respond VERB B-O
+to ADP B-O
+the DET B-O
+tyrosine NOUN B-O
+kinase NOUN B-O
+inhibitors NOUN B-O
+gefitinib PROPN B-O
+( PUNCT B-O
+Iressa PROPN B-O
+) PUNCT B-O
+or CCONJ B-O
+erlotinib PROPN B-O
+( PUNCT B-O
+Tarceva PROPN B-O
+) PUNCT B-O
+usually ADV B-O
+harbor VERB B-O
+somatic ADJ B-O
+gain NOUN B-O
+- PUNCT B-O
+of ADP B-O
+- PUNCT B-O
+function NOUN B-O
+mutations NOUN B-O
+in ADP B-O
+exons NOUN B-O
+encoding VERB B-O
+the DET B-O
+kinase NOUN B-O
+domain NOUN B-O
+of ADP B-O
+the DET B-O
+epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+EGFR PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Despite SCONJ B-O
+initial ADJ B-O
+responses NOUN B-O
+, PUNCT B-O
+patients NOUN B-O
+eventually ADV B-O
+progress VERB B-O
+by ADP B-O
+unknown ADJ B-O
+mechanisms NOUN B-O
+of ADP B-O
+“ PUNCT B-O
+acquired VERB B-O
+” PUNCT B-O
+resistance NOUN B-O
+. PUNCT B-O
+
+A DET B-O
+total NOUN B-O
+of ADP B-O
+1,045 NUM B-O
+genes NOUN B-O
+( PUNCT B-O
+551 NUM B-O
+up ADV B-O
+- PUNCT B-O
+regulated VERB B-O
+and CCONJ B-O
+494 NUM B-O
+down ADV B-O
+- PUNCT B-O
+regulated VERB B-O
+) PUNCT B-O
+were AUX B-O
+DE PROPN B-AC
+in ADP B-O
+the DET B-O
+FPC PROPN B-AC
+/ SYM B-O
+CC PROPN B-AC
+( PUNCT B-O
+region NOUN B-O
+1 NUM B-O
+, PUNCT B-O
+S1 NUM B-O
+Table PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+644 NUM B-O
+genes NOUN B-O
+( PUNCT B-O
+492 NUM B-O
+up ADV B-O
+- PUNCT B-O
+regulated VERB B-O
+and CCONJ B-O
+152 NUM B-O
+down ADV B-O
+- PUNCT B-O
+regulated VERB B-O
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+HP PROPN B-AC
+( PUNCT B-O
+region NOUN B-O
+2 NUM B-O
+, PUNCT B-O
+S2 NUM B-O
+Table PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+1,137 NUM B-O
+( PUNCT B-O
+526 NUM B-O
+up ADV B-O
+- PUNCT B-O
+regulated VERB B-O
+and CCONJ B-O
+611 NUM B-O
+downregulated ADJ B-O
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+RB PROPN B-AC
+( PUNCT B-O
+region NOUN B-O
+3 NUM B-O
+, PUNCT B-O
+S3 PROPN B-O
+Table PROPN B-O
+) PUNCT B-O
+( PUNCT B-O
+Fig NOUN B-O
+1A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Gene NOUN B-O
+set NOUN B-O
+enrichment NOUN B-O
+analysis NOUN B-O
+( PUNCT B-O
+using VERB B-O
+DAVID PROPN B-O
+, PUNCT B-O
+see VERB B-O
+Methods NOUN B-O
+) PUNCT B-O
+showed VERB B-O
+significant ADJ B-O
+differences NOUN B-O
+between ADP B-O
+the DET B-O
+regions NOUN B-O
+, PUNCT B-O
+i.e. X B-O
+, PUNCT B-O
+DE PROPN B-AC
+genes NOUN B-O
+from ADP B-O
+each PRON B-O
+of ADP B-O
+the DET B-O
+three NUM B-O
+regions NOUN B-O
+were AUX B-O
+present ADJ B-O
+in ADP B-O
+overlapping VERB B-O
+but CCONJ B-O
+not PART B-O
+identical ADJ B-O
+Kyoto PROPN B-LF
+Encyclopedia PROPN I-LF
+of ADP I-LF
+genes NOUN I-LF
+and CCONJ I-LF
+genomes NOUN I-LF
+( PUNCT B-O
+KEGG PROPN B-AC
+) PUNCT B-O
+pathways NOUN B-O
+( PUNCT B-O
+S4 PROPN B-O
+Table PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+NSE PROPN B-AC
+, PUNCT B-O
+neuron NOUN B-LF
+specific ADJ I-LF
+enolase NOUN I-LF
+. PUNCT B-O
+
+In ADP B-O
+a DET B-O
+next ADJ B-O
+step NOUN B-O
+we PRON B-O
+further ADV B-O
+quantified VERB B-O
+the DET B-O
+voltage NOUN B-O
+firing NOUN B-O
+threshold NOUN B-O
+( PUNCT B-O
+-28 NUM B-O
+– PUNCT B-O
+-49 NUM B-O
+mV NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+maximum ADJ B-O
+firing NOUN B-O
+frequency NOUN B-O
+( PUNCT B-O
+10–202 NUM B-O
+Hz NOUN B-O
+) PUNCT B-O
+in ADP B-O
+response NOUN B-O
+to ADP B-O
+a DET B-O
+100 NUM B-O
+pA NOUN B-O
+step NOUN B-O
+, PUNCT B-O
+the DET B-O
+amplitude NOUN B-O
+of ADP B-O
+both CCONJ B-O
+spontaneous ADJ B-O
+( PUNCT B-O
+18–80 NUM B-O
+mV NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+evoked VERB B-O
+action NOUN B-O
+potentials NOUN B-O
+( PUNCT B-O
+17–76 NUM B-O
+mV NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+amplitude NOUN B-O
+( PUNCT B-O
+0–18 NUM B-O
+mV NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+time NOUN B-O
+point NOUN B-O
+of ADP B-O
+the DET B-O
+fast ADJ B-LF
+after ADP I-LF
+- PUNCT I-LF
+hyperpolarization NOUN I-LF
+peak NOUN I-LF
+( PUNCT B-O
+fAHP PROPN B-AC
+) PUNCT B-O
+following VERB B-O
+a DET B-O
+spike NOUN B-O
+( PUNCT B-O
+0,2–3,8 NUM B-O
+ms NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Fluorescence NOUN B-LF
+correlation NOUN I-LF
+spectroscopy NOUN I-LF
+( PUNCT B-O
+FCS PROPN B-AC
+) PUNCT B-O
+measurements NOUN B-O
+were AUX B-O
+carried VERB B-O
+out ADP B-O
+with ADP B-O
+a DET B-O
+home NOUN B-O
+- PUNCT B-O
+made VERB B-O
+FCS PROPN B-AC
+setup NOUN B-O
+[ X B-O
+56,57 X B-O
+] X B-O
+including VERB B-O
+an DET B-O
+Olympus PROPN B-O
+IMT-2 PROPN B-O
+inverted ADJ B-O
+microscope NOUN B-O
+with ADP B-O
+a DET B-O
+40x NUM B-O
+, PUNCT B-O
+NA NOUN B-O
+1.2 NUM B-O
+water NOUN B-O
+immersion NOUN B-O
+objective NOUN B-O
+( PUNCT B-O
+Carl PROPN B-O
+Zeiss PROPN B-O
+, PUNCT B-O
+Jena PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Given VERB B-O
+clinicians NOUN B-O
+’ PUNCT B-O
+frequent ADJ B-O
+concerns NOUN B-O
+about ADP B-O
+unfavourable ADJ B-O
+outcomes NOUN B-O
+, PUNCT B-O
+Intensive PROPN B-LF
+Care PROPN I-LF
+Unit PROPN I-LF
+( PUNCT B-O
+ICU PROPN B-AC
+) PUNCT B-O
+triage NOUN B-O
+decisions NOUN B-O
+in ADP B-O
+acutely ADV B-O
+ill ADJ B-O
+cancer NOUN B-O
+patients NOUN B-O
+can AUX B-O
+be AUX B-O
+difficult ADJ B-O
+, PUNCT B-O
+as SCONJ B-O
+clinicians NOUN B-O
+may AUX B-O
+have VERB B-O
+doubts NOUN B-O
+about ADP B-O
+the DET B-O
+appropriateness NOUN B-O
+of ADP B-O
+an DET B-O
+ICU PROPN B-AC
+admission NOUN B-O
+. PUNCT B-O
+
+While SCONJ B-O
+Categories NOUN B-O
+I NUM B-O
+and CCONJ B-O
+II NUM B-O
+are AUX B-O
+integrated VERB B-O
+in ADP B-O
+the DET B-O
+swing NOUN B-O
+equation NOUN B-O
+, PUNCT B-O
+the DET B-O
+admittance NOUN B-LF
+matrix NOUN I-LF
+Y PROPN B-AC
+is AUX B-O
+modified VERB B-O
+to PART B-O
+incorporate VERB B-O
+Categories NOUN B-O
+III NUM B-O
+and CCONJ B-O
+IV NUM B-O
+in ADP B-O
+terms NOUN B-O
+of ADP B-O
+the DET B-O
+voltage NOUN B-O
+– PUNCT B-O
+current NOUN B-O
+relationship NOUN B-O
+. PUNCT B-O
+
+Further ADJ B-O
+cryogenic ADJ B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT B-O
+cryo-EM PROPN B-AC
+) PUNCT B-O
+maps NOUN B-O
+of ADP B-O
+the DET B-O
+CsgG PROPN B-O
+- PUNCT B-O
+CsgE PROPN B-O
+complex NOUN B-O
+indicate VERB B-O
+that SCONJ B-O
+CsgE PROPN B-O
+could AUX B-O
+oligomerize VERB B-O
+to PART B-O
+form VERB B-O
+nonamers NOUN B-O
+in ADP B-O
+the DET B-O
+periplasm NOUN B-O
+, PUNCT B-O
+“ PUNCT B-O
+capping VERB B-O
+” PUNCT B-O
+the DET B-O
+periplasmic ADJ B-O
+side NOUN B-O
+of ADP B-O
+the DET B-O
+CsgG PROPN B-O
+channel NOUN B-O
+[ PUNCT B-O
+26,27 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+produce VERB B-O
+LEGO PROPN B-AC
+libraries NOUN B-O
+, PUNCT B-O
+we PRON B-O
+designed VERB B-O
+a DET B-O
+set NOUN B-O
+of ADP B-O
+oligonucleotide NOUN B-O
+adapters NOUN B-O
+A NOUN B-O
+, PUNCT B-O
+B NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+C NOUN B-O
+( PUNCT B-O
+Figures NOUN B-O
+A NOUN B-O
+, PUNCT B-O
+B NOUN B-O
+in ADP B-O
+S1 NUM B-O
+Fig NOUN B-O
+) PUNCT B-O
+that PRON B-O
+allow VERB B-O
+( PUNCT B-O
+1 X B-O
+) PUNCT B-O
+highly ADV B-O
+optimized VERB B-O
+PCR NOUN B-O
+- PUNCT B-O
+based VERB B-O
+Suppression PROPN B-LF
+Subtractive PROPN I-LF
+Hybridization PROPN I-LF
+( PUNCT B-O
+SSH PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+two NUM B-O
+transcriptomes NOUN B-O
+[ X B-O
+7 X B-O
+] X B-O
+to PART B-O
+selectively ADV B-O
+amplify VERB B-O
+cDNA NOUN B-O
+sequences NOUN B-O
+from ADP B-O
+repressed VERB B-O
+polyadenylated VERB B-O
+transcripts NOUN B-O
+( PUNCT B-O
+see VERB B-O
+for ADP B-O
+schematic ADJ B-O
+design NOUN B-O
+Figures NOUN B-O
+C NOUN B-O
+, PUNCT B-O
+D NOUN B-O
+in ADP B-O
+S1 NUM B-O
+Fig NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+( PUNCT B-O
+2 X B-O
+) PUNCT B-O
+subsequent ADJ B-O
+enzymatic ADJ B-O
+processing NOUN B-O
+of ADP B-O
+selected VERB B-O
+cDNA NOUN B-O
+sequences NOUN B-O
+into ADP B-O
+a DET B-O
+library NOUN B-O
+of ADP B-O
+pRETRO PROPN B-O
+Super PROPN B-O
+shRNA NOUN B-O
+vectors NOUN B-O
+for ADP B-O
+screening NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+I NUM B-O
+in ADP B-O
+S1 NUM B-O
+Fig NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+* PUNCT B-O
+As ADP B-O
+compared VERB B-O
+with ADP B-O
+female NOUN B-O
+; PUNCT B-O
+Ref NOUN B-O
+: PUNCT B-O
+reference NOUN B-O
+category NOUN B-O
+; PUNCT B-O
+reduced VERB B-O
+staff NOUN B-O
+: PUNCT B-O
+weekend NOUN B-O
+and CCONJ B-O
+public ADJ B-O
+holydays NOUN B-O
+admissions NOUN B-O
+; PUNCT B-O
+RRT PROPN B-AC
+: PUNCT B-O
+renal ADJ B-LF
+replacement NOUN I-LF
+therapy NOUN I-LF
+; PUNCT B-O
+“ PUNCT B-O
+SAMU PROPN B-O
+” PUNCT B-O
+: PUNCT B-O
+Service PROPN B-O
+d’Aide PROPN B-O
+Médicale PROPN B-O
+Urgente PROPN B-O
+: PUNCT B-O
+mobile ADJ B-O
+emergency NOUN B-O
+team NOUN B-O
+. PUNCT B-O
+
+CTRL PROPN B-O
+, PUNCT B-O
+control NOUN B-O
+group NOUN B-O
+; PUNCT B-O
+ECD PROPN B-AC
+, PUNCT B-O
+early ADJ B-LF
+child NOUN I-LF
+development NOUN I-LF
+; PUNCT B-O
+EI PROPN B-O
+, PUNCT B-O
+Educación PROPN B-O
+Inicial PROPN B-O
+; PUNCT B-O
+ICDS PROPN B-O
+, PUNCT B-O
+Integrated PROPN B-O
+Child PROPN B-O
+Development PROPN B-O
+Services PROPN B-O
+; PUNCT B-O
+INT PROPN B-O
+, PUNCT B-O
+intervention NOUN B-O
+group NOUN B-O
+; PUNCT B-O
+RCT PROPN B-O
+, PUNCT B-O
+randomized VERB B-O
+controlled ADJ B-O
+trial NOUN B-O
+; PUNCT B-O
+RFS PROPN B-O
+, PUNCT B-O
+Responsive PROPN B-O
+Feeding PROPN B-O
+and CCONJ B-O
+Stimulation PROPN B-O
+; PUNCT B-O
+VIP PROPN B-O
+, PUNCT B-O
+Video PROPN B-O
+Interaction PROPN B-O
+Project PROPN B-O
+; PUNCT B-O
+VIPP PROPN B-O
+, PUNCT B-O
+video NOUN B-O
+- PUNCT B-O
+feedback NOUN B-O
+intervention NOUN B-O
+to PART B-O
+promote VERB B-O
+positive ADJ B-O
+parenting NOUN B-O
+; PUNCT B-O
+Of ADP B-O
+the DET B-O
+49,717 NUM B-O
+individuals NOUN B-O
+enrolled VERB B-O
+in ADP B-O
+the DET B-O
+D:A:D PROPN B-AC
+study NOUN B-O
+, PUNCT B-O
+27,215 NUM B-O
+( PUNCT B-O
+55 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+had VERB B-O
+the DET B-O
+required VERB B-O
+complete ADJ B-O
+covariate NOUN B-O
+data NOUN B-O
+after ADP B-O
+1 NUM B-O
+January PROPN B-O
+2004 NUM B-O
+and CCONJ B-O
+were AUX B-O
+included VERB B-O
+in ADP B-O
+this DET B-O
+analysis NOUN B-O
+, PUNCT B-O
+contributing VERB B-O
+202,034 NUM B-O
+person NOUN B-LF
+- PUNCT I-LF
+years NOUN I-LF
+( PUNCT B-O
+pyrs PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+follow NOUN B-O
+- PUNCT B-O
+up NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+calculated VERB B-O
+the DET B-O
+sensitivity NOUN B-O
+, PUNCT B-O
+specificity NOUN B-O
+and CCONJ B-O
+accuracy NOUN B-O
+of ADP B-O
+our PRON B-O
+algorithm NOUN B-O
+to PART B-O
+detect VERB B-O
+VVA PROPN B-AC
+after ADP B-O
+finding VERB B-O
+an DET B-O
+optimal ADJ B-O
+DCVV PROPN B-AC
+cut NOUN B-O
+- PUNCT B-O
+off NOUN B-O
+using VERB B-O
+Receiver PROPN B-LF
+Operating PROPN I-LF
+Characteristics NOUN I-LF
+( PUNCT B-O
+ROC PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Youden PROPN B-O
+- PUNCT B-O
+Index PROPN B-O
+( PUNCT B-O
+J NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+ROC PROPN B-AC
+curve NOUN B-O
+was AUX B-O
+generated VERB B-O
+using VERB B-O
+SPSS PROPN B-O
+. PUNCT B-O
+
+For ADP B-O
+all DET B-O
+statistical ADJ B-O
+analyses NOUN B-O
+, PUNCT B-O
+the DET B-O
+level NOUN B-O
+of ADP B-O
+significance NOUN B-O
+was AUX B-O
+set VERB B-O
+at ADP B-O
+p NOUN B-O
+< ADP B-O
+0.05 NUM B-O
+( PUNCT B-O
+two NUM B-O
+- PUNCT B-O
+tailed VERB B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Deletion NOUN B-O
+of ADP B-O
+kinases NOUN B-O
+regulated VERB B-O
+by ADP B-O
+Ras PROPN B-O
+such ADJ B-O
+as ADP B-O
+extracellular ADJ B-LF
+signal NOUN I-LF
+regulated VERB I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+ERK PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+glycogen NOUN B-O
+synthase NOUN B-O
+kinase NOUN B-O
+( PUNCT B-O
+GSK-3 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+mammalian ADJ B-LF
+target NOUN I-LF
+of ADP I-LF
+rapamycin NOUN I-LF
+( PUNCT B-O
+mTOR PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+discrete ADJ B-O
+populations NOUN B-O
+of ADP B-O
+MSNs PROPN B-AC
+also ADV B-O
+affects VERB B-O
+motor NOUN B-O
+activity NOUN B-O
+and/or CCONJ B-O
+responses NOUN B-O
+to ADP B-O
+psychostimulants NOUN B-O
+[ PUNCT B-O
+28–30 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+similar ADJ B-O
+effects NOUN B-O
+are AUX B-O
+observed VERB B-O
+upon SCONJ B-O
+changes NOUN B-O
+in ADP B-O
+Ras PROPN B-O
+activity NOUN B-O
+[ PUNCT B-O
+31,32 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+some DET B-O
+organisms NOUN B-O
+, PUNCT B-O
+additional ADJ B-O
+γ PUNCT B-LF
+- PUNCT I-LF
+tubulin NOUN I-LF
+complex NOUN I-LF
+proteins NOUN I-LF
+( PUNCT B-O
+GCPs PROPN B-AC
+) PUNCT B-O
+combine VERB B-O
+with ADP B-O
+the DET B-O
+γ PROPN B-AC
+to PART B-O
+form VERB B-O
+the DET B-O
+larger ADJ B-O
+γ PUNCT B-LF
+- PUNCT I-LF
+tubulin NOUN I-LF
+ring NOUN I-LF
+complex NOUN I-LF
+( PUNCT B-O
+-TuSCγ PROPN B-AC
+) PUNCT B-O
+; PUNCT B-O
+organisms NOUN B-O
+lacking VERB B-O
+these DET B-O
+additional ADJ B-O
+-TuRCGCPs PROPN B-AC
+are AUX B-O
+thought VERB B-O
+to PART B-O
+oligomerize VERB B-O
+γ PROPN B-AC
+into ADP B-O
+similar ADJ B-O
+ring NOUN B-O
+complexes NOUN B-O
+[ PUNCT B-O
+12,13 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+data NOUN B-O
+was AUX B-O
+normalized VERB B-O
+to ADP B-O
+the DET B-O
+H/L PROPN B-AC
+( PUNCT B-O
+Heavy ADJ B-LF
+/ SYM I-LF
+Light NOUN I-LF
+) PUNCT B-O
+ratio NOUN B-O
+of ADP B-O
+the DET B-O
+Pwp2p NOUN B-O
+bait NOUN B-O
+to ADP B-O
+correct VERB B-O
+for ADP B-O
+the DET B-O
+reduced VERB B-O
+purification NOUN B-O
+( PUNCT B-O
+the DET B-O
+H PROPN B-AC
+ratio NOUN B-O
+of ADP B-O
+Pwp2p NOUN B-O
+was AUX B-O
+set VERB B-O
+to ADP B-O
+1 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Weight NOUN B-O
+and CCONJ B-O
+height NOUN B-O
+were AUX B-O
+measured VERB B-O
+by ADP B-O
+trained VERB B-O
+professionals NOUN B-O
+to ADP B-O
+standardised ADJ B-O
+protocols NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+calculated VERB B-O
+as ADP B-O
+weight NOUN B-O
+divided VERB B-O
+by ADP B-O
+squared VERB B-O
+height NOUN B-O
+( PUNCT B-O
+kg NOUN B-O
+/ SYM B-O
+m2 NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+95 NUM B-O
+% NOUN B-O
+CI NOUN B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-O
+interval NOUN B-O
+; PUNCT B-O
+HR PROPN B-AC
+, PUNCT B-O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+PSA PROPN B-AC
+, PUNCT B-O
+prostate NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+antigen NOUN I-LF
+; PUNCT B-O
+pT NOUN B-O
+, PUNCT B-O
+pathological ADJ B-O
+staging NOUN B-O
+of ADP B-O
+the DET B-O
+primary ADJ B-O
+tumor NOUN B-O
+; PUNCT B-O
+RP PROPN B-AC
+, PUNCT B-O
+radical ADJ B-LF
+prostatectomy NOUN I-LF
+. PUNCT B-O
+
+Recent ADJ B-O
+studies NOUN B-O
+suggest VERB B-O
+that SCONJ B-O
+necroptosis NOUN B-O
+is AUX B-O
+mediated VERB B-O
+by ADP B-O
+receptor NOUN B-LF
+interacting VERB I-LF
+protein NOUN I-LF
+3 NUM I-LF
+( PUNCT B-O
+RIP3)[7 PROPN B-AC
+, PUNCT B-O
+8 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+SNP PROPN B-AC
+: PUNCT B-O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphism NOUN I-LF
+; PUNCT B-O
+CTEPH PROPN B-AC
+: PUNCT B-O
+chronic ADJ B-LF
+thromboembolic ADJ I-LF
+pulmonary ADJ I-LF
+hypertension NOUN I-LF
+; PUNCT B-O
+PE PROPN B-AC
+: PUNCT B-O
+pulmonary ADJ B-O
+embolism NOUN B-O
+; PUNCT B-O
+PAH PROPN B-AC
+: PUNCT B-O
+pulmonary ADJ B-LF
+arterial ADJ I-LF
+hypertension NOUN I-LF
+. PUNCT B-O
+
+We PRON B-O
+simulated VERB B-O
+populations NOUN B-O
+using VERB B-O
+an DET B-O
+agent NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+model NOUN I-LF
+( PUNCT B-O
+ABM PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+sampled VERB B-O
+them PRON B-O
+monthly ADV B-O
+for ADP B-O
+25 NUM B-O
+years NOUN B-O
+with ADP B-O
+a DET B-O
+total NOUN B-O
+of ADP B-O
+300 NUM B-O
+time NOUN B-O
+points NOUN B-O
+, PUNCT B-O
+where SCONJ B-O
+each DET B-O
+time NOUN B-O
+point NOUN B-O
+is AUX B-O
+a DET B-O
+snapshot NOUN B-O
+of ADP B-O
+changes NOUN B-O
+accumulated VERB B-O
+in ADP B-O
+the DET B-O
+parasite NOUN B-O
+population NOUN B-O
+during ADP B-O
+a DET B-O
+30 NUM B-O
+- PUNCT B-O
+day NOUN B-O
+period NOUN B-O
+. PUNCT B-O
+
+An DET B-O
+analysis NOUN B-O
+of ADP B-O
+the DET B-O
+putative ADJ B-O
+cis ADJ B-O
+- ADJ B-O
+regulatory ADJ B-O
+elements NOUN B-O
+that SCONJ B-O
+were AUX B-O
+present ADJ B-O
+in ADP B-O
+the DET B-O
+promoter NOUN B-O
+sequences NOUN B-O
+of ADP B-O
+aquaporin NOUN B-O
+genes NOUN B-O
+belonging VERB B-O
+to ADP B-O
+TIP PROPN B-AC
+subfamily NOUN B-O
+led VERB B-O
+to ADP B-O
+the DET B-O
+conclusion NOUN B-O
+that SCONJ B-O
+their PRON B-O
+expression NOUN B-O
+may AUX B-O
+be AUX B-O
+regulated VERB B-O
+in ADP B-O
+response NOUN B-O
+to ADP B-O
+hormones NOUN B-O
+such ADJ B-O
+as SCONJ B-O
+abscisic NOUN B-LF
+acid NOUN I-LF
+( PUNCT B-O
+ABA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+methyl NOUN B-LF
+jasmonate NOUN I-LF
+( PUNCT B-O
+MeJA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+auxin NOUN B-O
+and CCONJ B-O
+gibberellin NOUN B-O
+( PUNCT B-O
+GA PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+presence NOUN B-O
+of ADP B-O
+ABRE PROPN B-O
+in ADP B-O
+the DET B-O
+investigated VERB B-O
+promoters NOUN B-O
+suggests VERB B-O
+a DET B-O
+possible ADJ B-O
+role NOUN B-O
+of ADP B-O
+ABA PROPN B-AC
+in ADP B-O
+the DET B-O
+control NOUN B-O
+of ADP B-O
+HvTIP PROPN B-O
+expression NOUN B-O
+as SCONJ B-O
+has AUX B-O
+already ADV B-O
+been AUX B-O
+reported VERB B-O
+for ADP B-O
+some DET B-O
+TIP PROPN B-AC
+genes NOUN B-O
+in ADP B-O
+barley NOUN B-O
+. PUNCT B-O
+
+CS PROPN B-AC
+, PUNCT B-O
+cesarean ADJ B-LF
+section NOUN I-LF
+; PUNCT B-O
+HELLP PROPN B-AC
+, PUNCT B-O
+hemolysis NOUN B-O
+, PUNCT B-O
+elevated ADJ B-O
+liver NOUN B-O
+enzymes NOUN B-O
+, PUNCT B-O
+low ADJ B-O
+platelet NOUN B-O
+count NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+assessed VERB B-O
+the DET B-O
+efficiency NOUN B-O
+of ADP B-O
+gene NOUN B-O
+discovery NOUN B-O
+by ADP B-O
+calculating VERB B-O
+the DET B-O
+percentage NOUN B-O
+of ADP B-O
+known VERB B-O
+genes NOUN B-O
+tagged VERB B-O
+as ADP B-O
+a DET B-O
+function NOUN B-O
+of ADP B-O
+read VERB B-O
+number NOUN B-O
+for ADP B-O
+MF PROPN B-AC
+and CCONJ B-O
+compared VERB B-O
+this DET B-O
+value NOUN B-O
+to ADP B-O
+the DET B-O
+rate NOUN B-O
+of ADP B-O
+gene NOUN B-O
+discovery NOUN B-O
+obtained VERB B-O
+by ADP B-O
+expressed VERB B-LF
+sequence NOUN I-LF
+tags NOUN I-LF
+( PUNCT B-O
+ESTs PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+sorghum NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+2 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Alternative ADJ B-O
+, PUNCT B-O
+community NOUN B-O
+- PUNCT B-O
+based VERB B-O
+approaches NOUN B-O
+are AUX B-O
+required VERB B-O
+to PART B-O
+meet VERB B-O
+the DET B-O
+Joint PROPN B-LF
+United PROPN I-LF
+Nations PROPN I-LF
+Programme PROPN I-LF
+on ADP I-LF
+HIV PROPN I-LF
+/ SYM I-LF
+AIDS PROPN I-LF
+( PUNCT B-O
+UNAIDS PROPN B-AC
+) PUNCT B-O
+target NOUN B-O
+of ADP B-O
+diagnosing VERB B-O
+90 NUM B-O
+% NOUN B-O
+of ADP B-O
+those PRON B-O
+living VERB B-O
+with ADP B-O
+HIV PROPN B-O
+by ADP B-O
+2020 NUM B-O
+in ADP B-O
+this DET B-O
+age NOUN B-O
+group NOUN B-O
+. PUNCT B-O
+
+Baht PROPN B-O
+can AUX B-O
+be AUX B-O
+converted VERB B-O
+to ADP B-O
+$ SYM B-O
+US PROPN B-O
+by ADP B-O
+dividing VERB B-O
+by ADP B-O
+31.16 NUM B-O
+; PUNCT B-O
+T1MI PROPN B-AC
+, PUNCT B-O
+type NOUN B-O
+1 NUM B-O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+; PUNCT B-O
+ASCVD PROPN B-AC
+, PUNCT B-O
+atherosclerotic ADJ B-LF
+cardiovascular ADJ I-LF
+disease NOUN I-LF
+; PUNCT B-O
+QALY PROPN B-AC
+, PUNCT B-O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+- PUNCT I-LF
+year NOUN I-LF
+; PUNCT B-O
+ICER PROPN B-AC
+, PUNCT B-O
+incremental ADJ B-LF
+cost NOUN I-LF
+- PUNCT I-LF
+effectiveness NOUN I-LF
+ratio NOUN I-LF
+; PUNCT B-O
+Rama PROPN B-AC
+, PUNCT B-O
+Ramathibodi PROPN B-LF
+- PUNCT I-LF
+Electricity PROPN I-LF
+Generating PROPN I-LF
+Authority PROPN I-LF
+of ADP I-LF
+Thailand PROPN I-LF
+. PUNCT B-O
+
+Since SCONJ B-O
+histone NOUN B-O
+acetylation NOUN B-O
+is AUX B-O
+controlled VERB B-O
+by ADP B-O
+the DET B-O
+balance NOUN B-O
+of ADP B-O
+histone NOUN B-LF
+acetyltransferases NOUN I-LF
+( PUNCT B-O
+HATs PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+deacetylases NOUN B-O
+( PUNCT B-O
+HDACs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+next ADV B-O
+asked VERB B-O
+whether SCONJ B-O
+blocking VERB B-O
+HDAC PROPN B-AC
+function NOUN B-O
+would AUX B-O
+reactivate VERB B-O
+IFN PROPN B-AC
+- PUNCT B-O
+λ PUNCT B-O
+receptor NOUN B-O
+expression NOUN B-O
+in ADP B-O
+nonresponsive ADJ B-O
+cells NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+present ADJ B-O
+study NOUN B-O
+, PUNCT B-O
+we PRON B-O
+investigated VERB B-O
+the DET B-O
+effect NOUN B-O
+of ADP B-O
+a DET B-O
+sub ADJ B-O
+- PUNCT B-O
+chronic ADJ B-O
+treatment NOUN B-O
+with ADP B-O
+local ADJ B-LF
+cryotherapy NOUN I-LF
+( PUNCT B-O
+LC PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+widely ADV B-O
+- PUNCT B-O
+used VERB B-O
+rat NOUN B-O
+model NOUN B-O
+of ADP B-O
+adjuvant NOUN B-LF
+- PUNCT I-LF
+induced VERB I-LF
+arthritis NOUN I-LF
+( PUNCT B-O
+AIA PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Two NUM B-O
+modalities NOUN B-O
+of ADP B-O
+cryotherapy NOUN B-O
+were AUX B-O
+compared VERB B-O
+: PUNCT B-O
+local ADJ B-O
+ice NOUN B-O
+and CCONJ B-O
+cold ADJ B-O
+spray NOUN B-O
+application NOUN B-O
+. PUNCT B-O
+
+HRs PROPN B-AC
+were AUX B-O
+adjusted VERB B-O
+for ADP B-O
+age NOUN B-O
+, PUNCT B-O
+sex NOUN B-O
+, PUNCT B-O
+total ADJ B-O
+energy NOUN B-O
+intake NOUN B-O
+, PUNCT B-O
+education NOUN B-O
+, PUNCT B-O
+physical ADJ B-O
+activity NOUN B-O
+, PUNCT B-O
+smoking NOUN B-O
+status NOUN B-O
+, PUNCT B-O
+alcohol NOUN B-O
+intake NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+BMI PROPN B-AC
+. PUNCT B-O
+
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+HR PROPN B-AC
+, PUNCT B-O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+MetS PROPN B-AC
+, PUNCT B-O
+metabolic ADJ B-LF
+syndrome NOUN I-LF
+; PUNCT B-O
+uPDI PROPN B-AC
+, PUNCT B-O
+unhealthful ADJ B-LF
+plant NOUN I-LF
+- PUNCT I-LF
+based VERB I-LF
+diet NOUN I-LF
+index NOUN I-LF
+. PUNCT B-O
+
+CHW PROPN B-AC
+, PUNCT B-O
+community NOUN B-LF
+health NOUN I-LF
+worker NOUN I-LF
+; PUNCT B-O
+DV PROPN B-O
+, PUNCT B-O
+drug NOUN B-O
+vendor NOUN B-O
+/ SYM B-O
+shop NOUN B-O
+; PUNCT B-O
+HP PROPN B-O
+, PUNCT B-O
+healthcare NOUN B-O
+provider NOUN B-O
+; PUNCT B-O
+MA PROPN B-O
+, PUNCT B-O
+medical ADJ B-O
+assistant NOUN B-O
+; PUNCT B-O
+MD PROPN B-O
+, PUNCT B-O
+medical ADJ B-O
+doctor NOUN B-O
+; PUNCT B-O
+NA PROPN B-O
+, PUNCT B-O
+not PART B-O
+reported VERB B-O
+by ADP B-O
+study NOUN B-O
+authors NOUN B-O
+; PUNCT B-O
+pharm NOUN B-O
+, PUNCT B-O
+pharmacist NOUN B-O
+( PUNCT B-O
+trained VERB B-O
+) PUNCT B-O
+; PUNCT B-O
+PSI PROPN B-O
+, PUNCT B-O
+Population PROPN B-O
+Services PROPN B-O
+International PROPN B-O
+Research PROPN B-O
+and CCONJ B-O
+Metrics PROPN B-O
+; PUNCT B-O
+PW PROPN B-O
+, PUNCT B-O
+pregnant ADJ B-O
+women NOUN B-O
+. PUNCT B-O
+
+This DET B-O
+study NOUN B-O
+was AUX B-O
+undertaken VERB B-O
+in ADP B-O
+Kenyatta PROPN B-LF
+National PROPN I-LF
+Hospital PROPN I-LF
+( PUNCT B-O
+KNH PROPN B-AC
+) PUNCT B-O
+-the DET B-O
+largest ADJ B-O
+public ADJ B-O
+tertiary ADJ B-O
+referral NOUN B-O
+centre NOUN B-O
+in ADP B-O
+East PROPN B-O
+& CCONJ B-O
+Central PROPN B-O
+Africa PROPN B-O
+— PUNCT B-O
+to PART B-O
+help AUX B-O
+bridge VERB B-O
+existing VERB B-O
+AMR PROPN B-AC
+knowledge NOUN B-O
+and CCONJ B-O
+practice NOUN B-O
+gaps NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+extracted VERB B-O
+individuals NOUN B-O
+’ PUNCT B-O
+demographic ADJ B-O
+and CCONJ B-O
+residential ADJ B-O
+information NOUN B-O
+, PUNCT B-O
+including VERB B-O
+age NOUN B-O
+, PUNCT B-O
+sex NOUN B-O
+, PUNCT B-O
+residence NOUN B-O
+, PUNCT B-O
+income NOUN B-O
+quintile NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+whether SCONJ B-O
+the DET B-O
+individual NOUN B-O
+was AUX B-O
+resident NOUN B-O
+of ADP B-O
+a DET B-O
+long ADJ B-LF
+- PUNCT I-LF
+term NOUN I-LF
+care NOUN I-LF
+( PUNCT B-O
+LTC PROPN B-AC
+) PUNCT B-O
+facility NOUN B-O
+90 NUM B-O
+days NOUN B-O
+prior ADV B-O
+to ADP B-O
+the DET B-O
+testing NOUN B-O
+date NOUN B-O
+from ADP B-O
+the DET B-O
+database NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+studied VERB B-O
+responses NOUN B-O
+( PUNCT B-O
+dependent ADJ B-O
+variables NOUN B-O
+) PUNCT B-O
+were AUX B-O
+the DET B-O
+dissolution NOUN B-LF
+efficiency NOUN I-LF
+% NOUN B-O
+at ADP B-O
+10 NUM B-O
+min PROPN B-AC
+( PUNCT B-O
+Y1 PROPN B-O
+: PUNCT B-O
+DE PROPN B-AC
+( PUNCT B-O
+10 NUM B-O
+min PROPN B-AC
+) PUNCT B-O
+% NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+dissolution NOUN B-LF
+efficiency NOUN I-LF
+% NOUN B-O
+at ADP B-O
+30 NUM B-O
+min PROPN B-AC
+( PUNCT B-O
+Y2 PROPN B-O
+: PUNCT B-O
+DE PROPN B-AC
+( PUNCT B-O
+30 NUM B-O
+min PROPN B-AC
+) PUNCT B-O
+% NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+mean ADJ B-LF
+dissolution NOUN I-LF
+time NOUN I-LF
+( PUNCT B-O
+Y3 NOUN B-O
+: PUNCT B-O
+MDT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+disintegration NOUN B-LF
+time NOUN I-LF
+( PUNCT B-O
+Y4 PROPN B-O
+: PUNCT B-O
+DT PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+wetting NOUN B-LF
+time NOUN I-LF
+( PUNCT B-O
+Y5 NOUN B-O
+: PUNCT B-O
+WT PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Responses NOUN B-O
+of ADP B-O
+the DET B-O
+prepared VERB B-O
+ODTs PROPN B-AC
+are AUX B-O
+listed VERB B-O
+in ADP B-O
+Table NOUN B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+in ADP B-O
+S1 PROPN B-O
+File PROPN B-O
+. PUNCT B-O
+
+This PRON B-O
+is AUX B-O
+in ADP B-O
+contrast NOUN B-O
+to ADP B-O
+the DET B-O
+traditional ADJ B-O
+physician NOUN B-O
+- PUNCT B-O
+assessed VERB B-O
+Expanded PROPN B-LF
+Disability PROPN I-LF
+Status PROPN I-LF
+Scale PROPN I-LF
+( PUNCT B-O
+EDSS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+the DET B-O
+primary ADJ B-O
+outcome NOUN B-O
+favoured VERB B-O
+in ADP B-O
+most ADJ B-O
+MS PROPN B-AC
+trials NOUN B-O
+despite SCONJ B-O
+several ADJ B-O
+well ADV B-O
+- PUNCT B-O
+documented VERB B-O
+limitations NOUN B-O
+, PUNCT B-O
+including VERB B-O
+poor ADJ B-O
+interrater NOUN B-O
+and CCONJ B-O
+intrarater ADJ B-O
+reliability NOUN B-O
+and CCONJ B-O
+a DET B-O
+limited ADJ B-O
+sensitivity NOUN B-O
+to ADP B-O
+change NOUN B-O
+over ADP B-O
+the DET B-O
+time NOUN B-O
+frame NOUN B-O
+of ADP B-O
+2–3 NUM B-O
+years NOUN B-O
+, PUNCT B-O
+especially ADV B-O
+in ADP B-O
+progressive ADJ B-O
+MS PROPN B-AC
+[ PUNCT B-O
+16–20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Compared VERB B-O
+with ADP B-O
+LPS PROPN B-AC
+alone ADV B-O
+, PUNCT B-O
+at ADP B-O
+Vm PROPN B-AC
+values NOUN B-O
+negative ADJ B-O
+from ADP B-O
+the DET B-O
+reversal NOUN B-LF
+NCX PROPN B-AC
+potential NOUN I-LF
+( PUNCT B-O
+Erev PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+additional ADJ B-O
+HS PROPN B-AC
+exposure NOUN B-O
+enhanced VERB B-O
+NCX PROPN B-AC
+inward ADJ B-O
+current NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+4C NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Altogether ADV B-O
+, PUNCT B-O
+this PRON B-O
+suggests VERB B-O
+that SCONJ B-O
+NCX PROPN B-AC
+mediates VERB B-O
+Na+ NOUN B-O
+entry NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+location NOUN B-O
+of ADP B-O
+weaker ADJ B-O
+lipid NOUN B-O
+binding VERB B-O
+sites NOUN B-O
+is AUX B-O
+therefore ADV B-O
+usually ADV B-O
+observed VERB B-O
+using VERB B-O
+classical ADJ B-O
+molecular ADJ B-LF
+dynamics NOUN I-LF
+( PUNCT B-O
+MD PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+planned VERB B-O
+individual ADJ B-LF
+participant NOUN I-LF
+data NOUN I-LF
+( PUNCT B-O
+IPD PROPN B-AC
+) PUNCT B-O
+meta NOUN B-O
+- NOUN B-O
+analysis NOUN B-O
+( PUNCT B-O
+PROSPERO PROPN B-O
+CRD42017072683 NUM B-O
+) PUNCT B-O
+may AUX B-O
+prove VERB B-O
+helpful ADJ B-O
+to PART B-O
+further ADV B-O
+explore VERB B-O
+possible ADJ B-O
+sex NOUN B-O
+differences NOUN B-O
+in ADP B-O
+the DET B-O
+effects NOUN B-O
+of ADP B-O
+macronutrient NOUN B-O
+supplements NOUN B-O
+in ADP B-O
+human ADJ B-O
+infants NOUN B-O
+born VERB B-O
+small ADJ B-O
+. PUNCT B-O
+
+We PRON B-O
+used VERB B-O
+a DET B-O
+novel ADJ B-O
+in ADP B-O
+vitro X B-O
+assay NOUN B-O
+( PUNCT B-O
+for ADP B-O
+gamma NOUN B-LF
+- NOUN I-LF
+interferon NOUN I-LF
+[ PUNCT B-O
+IFN-γ PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+release NOUN B-O
+to PART B-O
+establish VERB B-O
+LTBI PROPN B-AC
+and CCONJ B-O
+a DET B-O
+questionnaire NOUN B-O
+to PART B-O
+address VERB B-O
+risk NOUN B-O
+factors NOUN B-O
+. PUNCT B-O
+
+Fenland PROPN B-O
+Study PROPN B-O
+participants NOUN B-O
+undergo VERB B-O
+a DET B-O
+health NOUN B-O
+assessment NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+blood NOUN B-O
+samples NOUN B-O
+are AUX B-O
+collected VERB B-O
+for ADP B-O
+the DET B-O
+genotyping NOUN B-O
+of ADP B-O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT B-O
+SNPs PROPN B-AC
+) PUNCT B-O
+associated VERB B-O
+with ADP B-O
+type NOUN B-O
+2 NUM B-O
+diabetes NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+ratio NOUN B-LF
+of ADP I-LF
+nonsynonymous ADJ I-LF
+to PART I-LF
+synonymous ADJ I-LF
+substitutions NOUN I-LF
+( PUNCT B-O
+dN/dS PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+calculated VERB B-O
+in ADP B-O
+phylogenetic ADJ B-LF
+analysis NOUN I-LF
+by ADP I-LF
+maximum ADJ I-LF
+likelihood NOUN I-LF
+( PUNCT B-O
+PAML PROPN B-AC
+) PUNCT B-O
+software NOUN B-O
+[ X B-O
+39 X B-O
+] X B-O
+using VERB B-O
+a DET B-O
+two NUM B-O
+- PUNCT B-O
+ratio NOUN B-O
+maximum ADJ B-O
+- PUNCT B-O
+likelihood NOUN B-O
+analysis NOUN B-O
+between ADP B-O
+the DET B-O
+human ADJ B-LF
+haplotype NOUN I-LF
+'s PART I-LF
+most ADV I-LF
+recent ADJ I-LF
+common ADJ I-LF
+ancestor NOUN I-LF
+( PUNCT B-O
+HH PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+human ADJ B-O
+- PUNCT B-O
+chimpanzee NOUN B-O
+-MRCAMRCA PROPN B-AC
+( PUNCT B-O
+Figure PROPN B-O
+5B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+measurement NOUN B-O
+, PUNCT B-O
+which PRON B-O
+only ADV B-O
+evaluates VERB B-O
+fixed VERB B-O
+changes NOUN B-O
+, PUNCT B-O
+is AUX B-O
+used VERB B-O
+to PART B-O
+determine VERB B-O
+selective ADJ B-O
+pressures NOUN B-O
+in ADP B-O
+a DET B-O
+coding VERB B-O
+region NOUN B-O
+, PUNCT B-O
+where SCONJ B-O
+values NOUN B-O
+> ADP B-O
+1 NUM B-O
+suggest VERB B-O
+positive ADJ B-O
+selection NOUN B-O
+, PUNCT B-O
+while SCONJ B-O
+values NOUN B-O
+< ADP B-O
+1 NUM B-O
+indicate VERB B-O
+purifying VERB B-O
+selection NOUN B-O
+. PUNCT B-O
+
+Fig NOUN B-O
+5 NUM B-O
+shows VERB B-O
+immunohistochemistry NOUN B-LF
+( PUNCT B-O
+IHC PROPN B-AC
+) PUNCT B-O
+results NOUN B-O
+in ADP B-O
+benign ADJ B-O
+prostate NOUN B-O
+tissue NOUN B-O
+and CCONJ B-O
+prostate NOUN B-O
+adenocarcinoma NOUN B-O
+according VERB B-O
+to ADP B-O
+pT NOUN B-O
+stage NOUN B-O
+and CCONJ B-O
+Gleason PROPN B-O
+score NOUN B-O
+. PUNCT B-O
+
+Among ADP B-O
+the DET B-O
+approximately ADV B-O
+70 NUM B-O
+members NOUN B-O
+in ADP B-O
+the DET B-O
+TRIM PROPN B-AC
+family NOUN B-O
+, PUNCT B-O
+TRIM59 PROPN B-O
+stood VERB B-O
+out ADP B-O
+as ADP B-O
+one NUM B-O
+of ADP B-O
+the DET B-O
+most ADV B-O
+differentially ADV B-O
+expressed VERB B-O
+genes NOUN B-O
+, PUNCT B-O
+with ADP B-O
+its PRON B-O
+expression NOUN B-O
+ubiquitously ADV B-O
+up ADV B-O
+- ADJ B-O
+regulated VERB B-O
+by ADP B-O
+1.6- NUM B-O
+to PART B-O
+6.3 NUM B-O
+- ADJ B-O
+fold NOUN B-O
+in ADP B-O
+12 NUM B-O
+analyzed VERB B-O
+cancer NOUN B-O
+types NOUN B-O
+compared VERB B-O
+with ADP B-O
+the DET B-O
+adjacent ADJ B-O
+normal ADJ B-O
+tissues NOUN B-O
+( PUNCT B-O
+Figs PROPN B-O
+1A NOUN B-O
+and CCONJ B-O
+S1A PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Particularly ADV B-O
+, PUNCT B-O
+in ADP B-O
+breast NOUN B-LF
+invasive ADJ I-LF
+carcinoma NOUN I-LF
+( PUNCT B-O
+BRCA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+TRIM59 PROPN B-O
+mRNA NOUN B-O
+level NOUN B-O
+was AUX B-O
+significantly ADV B-O
+increased VERB B-O
+in ADP B-O
+tumor NOUN B-O
+sites NOUN B-O
+( PUNCT B-O
+red ADJ B-O
+plot NOUN B-O
+) PUNCT B-O
+compared VERB B-O
+with ADP B-O
+its PRON B-O
+expression NOUN B-O
+in ADP B-O
+normal ADJ B-O
+adjacent ADJ B-O
+tissues NOUN B-O
+( PUNCT B-O
+blue ADJ B-O
+plot NOUN B-O
+; PUNCT B-O
+fold NOUN B-O
+change NOUN B-O
+= SYM B-O
+4.03 NUM B-O
+, PUNCT B-O
+P NOUN B-O
+value NOUN B-O
+= SYM B-O
+2.9 NUM B-O
+× PUNCT B-O
+10−28 NUM B-O
+; PUNCT B-O
+S1A PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+analyses NOUN B-O
+of ADP B-O
+frailty NOUN B-O
+categories NOUN B-O
+, PUNCT B-O
+only ADV B-O
+the DET B-O
+G-8 PROPN B-LF
+Geriatric PROPN I-LF
+Screening PROPN I-LF
+Tool PROPN I-LF
+( PUNCT B-O
+G8 PROPN B-AC
+) PUNCT B-O
+score NOUN B-O
+added VERB B-O
+statistically ADV B-O
+significant ADJ B-O
+predictive ADJ B-O
+value NOUN B-O
+( PUNCT B-O
+delta NOUN B-O
+C NOUN B-O
+: PUNCT B-O
+1.6 NUM B-O
+[ PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI NOUN B-O
+: PUNCT B-O
+0.4–2.8 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+( PUNCT B-O
+S10 PROPN B-O
+Table PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+March PROPN B-O
+2016 NUM B-O
+, PUNCT B-O
+HRSA PROPN B-AC
+awarded VERB B-O
+$ SYM B-O
+94 NUM B-O
+million NUM B-O
+through ADP B-O
+the DET B-O
+Substance PROPN B-LF
+Abuse PROPN I-LF
+Service PROPN I-LF
+Expansion PROPN I-LF
+( PUNCT B-O
+SASE PROPN B-AC
+) PUNCT B-O
+supplemental ADJ B-O
+grants NOUN B-O
+to ADP B-O
+271 NUM B-O
+or CCONJ B-O
+20 NUM B-O
+% NOUN B-O
+of ADP B-O
+HCs PROPN B-AC
+, PUNCT B-O
+with ADP B-O
+supplementary ADJ B-O
+funding NOUN B-O
+ranging VERB B-O
+from ADP B-O
+$ SYM B-O
+217,000 NUM B-O
+to ADP B-O
+$ SYM B-O
+406,000 NUM B-O
+. PUNCT B-O
+
+FisB PROPN B-AC
+, PUNCT B-O
+fission NOUN B-LF
+protein NOUN I-LF
+B. NOUN I-LF
+Consistent ADJ B-O
+with ADP B-O
+this PRON B-O
+, PUNCT B-O
+ICP47 PROPN B-O
+protects VERB B-O
+HSV PROPN B-AC
+- PUNCT B-O
+infected VERB B-O
+human ADJ B-O
+fibroblasts NOUN B-O
+from ADP B-O
+destruction NOUN B-O
+by ADP B-O
+cytotoxic ADJ B-LF
+T PROPN I-LF
+lymphocytes NOUN I-LF
+( PUNCT B-O
+CTLs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+while SCONJ B-O
+murine ADJ B-O
+fibroblasts NOUN B-O
+are AUX B-O
+not PART B-O
+protected VERB B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+These DET B-O
+data NOUN B-O
+were AUX B-O
+then ADV B-O
+analyzed VERB B-O
+via ADP B-O
+a DET B-O
+one NUM B-O
+- PUNCT B-O
+way NOUN B-O
+repeated VERB B-O
+measures NOUN B-O
+analysis NOUN B-LF
+of ADP I-LF
+variance NOUN I-LF
+( PUNCT B-O
+ANOVA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+Fisher PROPN B-O
+’s PART B-O
+post X B-O
+hoc X B-O
+analysis NOUN B-O
+of ADP B-O
+each DET B-O
+experimental ADJ B-O
+treatment NOUN B-O
+group NOUN B-O
+compared VERB B-O
+to ADP B-O
+vehicle NOUN B-O
+following VERB B-O
+a DET B-O
+significant ADJ B-O
+ANOVA PROPN B-AC
+( PUNCT B-O
+P NOUN B-O
+< ADP B-O
+0.05 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+plotted VERB B-O
+as ADP B-O
+a DET B-O
+mean NOUN B-O
+± ADJ B-O
+S.E.M. NOUN B-O
+for ADP B-O
+the DET B-O
+group NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+have AUX B-O
+also ADV B-O
+challenged VERB B-O
+our PRON B-O
+whole ADJ B-O
+blood NOUN B-O
+samples NOUN B-O
+with ADP B-O
+either CCONJ B-O
+intact ADJ B-O
+bacterial ADJ B-O
+( PUNCT B-O
+E.coli PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+virus NOUN B-O
+( PUNCT B-O
+HSV-1 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+rather ADV B-O
+than ADP B-O
+specific ADJ B-O
+Toll NOUN B-LF
+like ADP I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+TLR PROPN B-AC
+) PUNCT B-O
+agonists NOUN B-O
+like ADP B-O
+lipopolysaccharide NOUN B-LF
+( PUNCT B-O
+LPS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+since SCONJ B-O
+we PRON B-O
+considered VERB B-O
+intact ADJ B-O
+pathogens NOUN B-O
+more ADV B-O
+representative ADJ B-O
+of ADP B-O
+in X B-O
+vivo X B-O
+infections NOUN B-O
+. PUNCT B-O
+
+* PUNCT B-O
+Value NOUN B-O
+of ADP B-O
+% NOUN B-O
+DNA NOUN B-LF
+repair NOUN I-LF
+capacity NOUN I-LF
+( PUNCT B-O
+DRC PROPN B-AC
+) PUNCT B-O
+measured VERB B-O
+in ADP B-O
+lymphocytes NOUN B-O
+expressed VERB B-O
+as ADP B-O
+mean NOUN B-O
+( PUNCT B-O
+X NOUN B-O
+¯ NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+± NOUN B-O
+1 NUM B-O
+standard ADJ B-O
+deviation NOUN B-O
+( PUNCT B-O
+SD NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+median ADJ B-O
+values NOUN B-O
+including VERB B-O
+percentile NOUN B-O
+25 NUM B-O
+( PUNCT B-O
+P25 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+percentile NOUN B-O
+75 NUM B-O
+( PUNCT B-O
+P75 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Those DET B-O
+incident NOUN B-O
+cases NOUN B-O
+with ADP B-O
+sequelae NOUN B-O
+( PUNCT B-O
+or CCONJ B-O
+diseased ADJ B-O
+individuals NOUN B-O
+) PUNCT B-O
+were AUX B-O
+assigned VERB B-O
+years NOUN B-LF
+of ADP I-LF
+life NOUN I-LF
+lost VERB I-LF
+( PUNCT B-O
+YLLs PROPN B-AC
+) PUNCT B-O
+if SCONJ B-O
+fatal ADJ B-O
+or CCONJ B-O
+years NOUN B-LF
+lived VERB I-LF
+with ADP I-LF
+disability NOUN I-LF
+( PUNCT B-O
+YLDs PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+a DET B-O
+disability NOUN B-LF
+weight NOUN I-LF
+( PUNCT B-O
+DW PROPN B-AC
+) PUNCT B-O
+that PRON B-O
+depended VERB B-O
+on ADP B-O
+the DET B-O
+severity NOUN B-O
+of ADP B-O
+the DET B-O
+disease NOUN B-O
+. PUNCT B-O
+
+Nutrient NOUN B-O
+intake NOUN B-O
+stimulates VERB B-O
+production NOUN B-O
+of ADP B-O
+circulating VERB B-O
+Drosophila PROPN B-LF
+insulin NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+peptides NOUN I-LF
+( PUNCT B-O
+Dilps PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+activate VERB B-O
+the DET B-O
+insulin NOUN B-O
+/ SYM B-O
+IGF-1 PROPN B-AC
+receptor NOUN B-O
+( PUNCT B-O
+InR PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+leading VERB B-O
+to ADP B-O
+the DET B-O
+recruitment NOUN B-O
+of ADP B-O
+the DET B-O
+phosphatidyl NOUN B-LF
+inositol-3 NOUN I-LF
+- PUNCT I-LF
+kinase NOUN I-LF
+( PUNCT B-O
+PI3K PROPN B-AC
+— PUNCT B-O
+composed VERB B-O
+of ADP B-O
+two NUM B-O
+subunits NOUN B-O
+, PUNCT B-O
+p60 NOUN B-O
+and CCONJ B-O
+p110 NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+coverts VERB B-O
+phosphatidyl NOUN B-LF
+inositol NOUN I-LF
+phosphate NOUN I-LF
+( PUNCT B-O
+PIP)2 PROPN B-AC
+to ADP B-O
+PIP3 PROPN B-O
+at ADP B-O
+the DET B-O
+plasma NOUN B-O
+membrane NOUN B-O
+of ADP B-O
+signal NOUN B-O
+- PUNCT B-O
+receiving VERB B-O
+cells NOUN B-O
+( PUNCT B-O
+a DET B-O
+process NOUN B-O
+antagonised VERB B-O
+by ADP B-O
+the DET B-O
+phosphatase NOUN B-LF
+and CCONJ I-LF
+tensin NOUN I-LF
+homolog NOUN I-LF
+PTEN PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+3 NUM B-O
+, PUNCT B-O
+20–30 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+AMR PROPN B-AC
+, PUNCT B-O
+asthma NOUN B-LF
+medication NOUN I-LF
+ratio NOUN I-LF
+; PUNCT B-O
+CI PROPN B-O
+, PUNCT B-O
+confidence NOUN B-O
+interval NOUN B-O
+; PUNCT B-O
+GAM PROPN B-AC
+, PUNCT B-O
+generalised ADJ B-LF
+additive ADJ I-LF
+model NOUN I-LF
+; PUNCT B-O
+WIMD PROPN B-AC
+, PUNCT B-O
+Welsh PROPN B-LF
+Index PROPN I-LF
+of ADP I-LF
+Multiple PROPN I-LF
+Deprivation PROPN I-LF
+. PUNCT B-O
+
+ALT PROPN B-AC
+serum NOUN B-O
+concentration NOUN B-O
+was AUX B-O
+analyzed VERB B-O
+as SCONJ B-O
+categorical ADJ B-O
+variable NOUN B-O
+in ADP B-O
+this DET B-O
+model NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+indicated VERB B-O
+. PUNCT B-O
+
+w PROPN B-O
+, PUNCT B-O
+women NOUN B-O
+; PUNCT B-O
+m PROPN B-O
+, PUNCT B-O
+men NOUN B-O
+; PUNCT B-O
+ALT PROPN B-AC
+, PUNCT B-O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+; PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+γGT PROPN B-O
+, PUNCT B-O
+γ PUNCT B-O
+- PUNCT B-O
+glutamyl NOUN B-O
+transferase NOUN B-O
+; PUNCT B-O
+IFN PROPN B-AC
+, PUNCT B-O
+interferon NOUN B-LF
+; PUNCT B-O
+INR PROPN B-AC
+, PUNCT B-O
+international ADJ B-LF
+normalized ADJ I-LF
+ratio NOUN I-LF
+; PUNCT B-O
+IFN PROPN B-AC
+, PUNCT B-O
+interferon NOUN B-LF
+; PUNCT B-O
+ULN PROPN B-AC
+, PUNCT B-O
+upper ADJ B-LF
+limit NOUN I-LF
+of ADP I-LF
+normal ADJ I-LF
+. PUNCT B-O
+
+In ADP B-O
+spite NOUN B-O
+of ADP B-O
+the DET B-O
+considerable ADJ B-O
+body NOUN B-O
+of ADP B-O
+research NOUN B-O
+on ADP B-O
+NDDs PROPN B-AC
+such ADJ B-O
+as ADP B-O
+Alzheimer PROPN B-LF
+’s PART I-LF
+disease NOUN I-LF
+( PUNCT B-O
+AD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+amyotrophic ADJ B-LF
+lateral ADJ I-LF
+sclerosis NOUN I-LF
+( PUNCT B-O
+ALS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Huntington PROPN B-LF
+’s PART I-LF
+disease NOUN I-LF
+( PUNCT B-O
+HD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+multiple ADJ B-LF
+sclerosis NOUN I-LF
+( PUNCT B-O
+MS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Parkinson PROPN B-LF
+’s PART I-LF
+disease NOUN I-LF
+( PUNCT B-O
+PD PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+schizophrenia NOUN B-LF
+( PUNCT B-O
+SCHIZ PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+effective ADJ B-O
+treatment NOUN B-O
+for ADP B-O
+preventing VERB B-O
+the DET B-O
+progressive ADJ B-O
+neuronal ADJ B-O
+loss NOUN B-O
+is AUX B-O
+yet ADV B-O
+to PART B-O
+be AUX B-O
+available ADJ B-O
+[ PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+LAM PROPN B-AC
+, PUNCT B-O
+lipoarabinomannan NOUN B-LF
+assay NOUN I-LF
+; PUNCT B-O
+TB PROPN B-AC
+, PUNCT B-O
+tuberculosis NOUN B-LF
+; PUNCT B-O
+Xpert PROPN B-AC
+, PUNCT B-O
+Xpert PROPN B-LF
+MTB PROPN I-LF
+Xpert PROPN B-AC
+/ SYM I-LF
+MTB PROPN B-AC
+RIF PROPN I-LF
+assay NOUN I-LF
+. PUNCT B-O
+
+“ PUNCT B-O
+… PUNCT B-O
+any DET B-O
+work NOUN B-O
+[ X B-O
+done VERB B-O
+] X B-O
+PA PROPN B-AC
+[ X B-O
+posteroanterior ADJ B-LF
+] X B-O
+, PUNCT B-O
+especially ADV B-O
+chests NOUN B-O
+, PUNCT B-O
+I PRON B-O
+always ADV B-O
+like ADP B-O
+to PART B-O
+have AUX B-O
+a DET B-O
+[ X B-O
+radiopaque ADJ B-O
+] X B-O
+marker NOUN B-O
+on ADP B-O
+, PUNCT B-O
+or CCONJ B-O
+sinuses NOUN B-O
+or CCONJ B-O
+skulls NOUN B-O
+because SCONJ B-O
+if SCONJ B-O
+you PRON B-O
+do AUX B-O
+get VERB B-O
+dextrocardia NOUN B-O
+or CCONJ B-O
+something PRON B-O
+like ADP B-O
+that SCONJ B-O
+… PUNCT B-O
+you PRON B-O
+can AUX B-O
+stand VERB B-O
+in ADP B-O
+front NOUN B-O
+of ADP B-O
+the DET B-O
+… PUNCT B-O
+film NOUN B-O
+[ X B-O
+detector NOUN B-O
+] X B-O
+where SCONJ B-O
+your PRON B-O
+marker NOUN B-O
+was AUX B-O
+and CCONJ B-O
+check VERB B-O
+, PUNCT B-O
+was AUX B-O
+it PRON B-O
+a DET B-O
+left NOUN B-O
+or CCONJ B-O
+right NOUN B-O
+and CCONJ B-O
+then ADV B-O
+double ADV B-O
+check VERB B-O
+yourself PRON B-O
+that SCONJ B-O
+you PRON B-O
+have AUX B-O
+actually ADV B-O
+labelled VERB B-O
+it PRON B-O
+correctly ADV B-O
+. PUNCT B-O
+
+Fluorescence NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+cell NOUN I-LF
+sorting NOUN I-LF
+( PUNCT B-O
+FACS PROPN B-AC
+) PUNCT B-O
+sorting NOUN B-O
+to PART B-O
+enrich VERB B-O
+for ADP B-O
+glioma NOUN B-O
+stem NOUN B-O
+cells NOUN B-O
+has AUX B-O
+relied VERB B-O
+on ADP B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+the DET B-O
+glycosylated VERB B-O
+form NOUN B-O
+of ADP B-O
+the DET B-O
+cell NOUN B-O
+surface NOUN B-O
+marker NOUN B-O
+CD133 NOUN B-O
+( PUNCT B-O
+Prominin-1 NOUN B-O
+): PUNCT B-O
+a DET B-O
+protein NOUN B-O
+whose DET B-O
+role NOUN B-O
+in ADP B-O
+tumorigenesis NOUN B-O
+and CCONJ B-O
+glioma NOUN B-O
+biology NOUN B-O
+remains VERB B-O
+unclear ADJ B-O
+[ PUNCT B-O
+27 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Among ADP B-O
+the DET B-O
+methodologies NOUN B-O
+used VERB B-O
+to ADP B-O
+ascertain VERB B-O
+cause NOUN B-LF
+of ADP I-LF
+death NOUN I-LF
+( PUNCT B-O
+CoD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+those PRON B-O
+derived VERB B-O
+from ADP B-O
+the DET B-O
+verbal ADJ B-O
+autopsy NOUN B-O
+lack VERB B-O
+specificity NOUN B-O
+with ADP B-O
+regard NOUN B-O
+to ADP B-O
+most ADJ B-O
+biological ADJ B-O
+causes NOUN B-O
+of ADP B-O
+death NOUN B-O
+. PUNCT B-O
+
+EASI PROPN B-AC
+, PUNCT B-O
+Eczema PROPN B-LF
+Area PROPN I-LF
+and CCONJ I-LF
+Severity PROPN I-LF
+Index PROPN I-LF
+. PUNCT B-O
+
+We PRON B-O
+found VERB B-O
+biological ADJ B-O
+factors NOUN B-O
+including VERB B-O
+girls NOUN B-O
+experiencing VERB B-O
+early ADJ B-O
+menarche NOUN B-O
+, PUNCT B-O
+having VERB B-O
+lighter ADJ B-O
+periods NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+; PUNCT B-O
+household NOUN B-O
+level NOUN B-O
+factors NOUN B-O
+including VERB B-O
+being AUX B-O
+unhappy ADJ B-O
+at ADP B-O
+home NOUN B-O
+, PUNCT B-O
+being AUX B-O
+orphaned VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+coming VERB B-O
+from ADP B-O
+poorer ADJ B-O
+households NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+social ADJ B-O
+factors NOUN B-O
+including VERB B-O
+experiencing VERB B-O
+harassment NOUN B-O
+for ADP B-O
+sex NOUN B-O
+both PRON B-O
+in ADP B-O
+and CCONJ B-O
+out ADP B-O
+of ADP B-O
+school NOUN B-O
+or CCONJ B-O
+being AUX B-O
+touched VERB B-O
+indecently ADV B-O
+were AUX B-O
+significantly ADV B-O
+associated VERB B-O
+with ADP B-O
+girls NOUN B-O
+’ PUNCT B-O
+sexual ADJ B-O
+and CCONJ B-O
+reproductive ADJ B-O
+harms NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+pregnancy NOUN B-O
+, PUNCT B-O
+HSV-2 PROPN B-AC
+, PUNCT B-O
+and/or CCONJ B-O
+HIV PROPN B-O
+. PUNCT B-O
+
+L1 PROPN B-O
+, PUNCT B-O
+L2 PROPN B-O
+, PUNCT B-O
+L3 PROPN B-O
+= PUNCT B-O
+Languages NOUN B-O
+1–3 NUM B-O
+. PUNCT B-O
+
+fMRI PROPN B-AC
+, PUNCT B-O
+functional ADJ B-LF
+MRI NOUN I-LF
+; PUNCT B-O
+lPL PROPN B-AC
+, PUNCT B-O
+left ADJ B-LF
+parietal ADJ I-LF
+lobe NOUN I-LF
+; PUNCT B-O
+POz PROPN B-AC
+, PUNCT B-O
+midline ADJ B-LF
+posterior ADJ I-LF
+location NOUN I-LF
+according VERB I-LF
+to ADP I-LF
+the DET I-LF
+10–20 NUM I-LF
+system NOUN I-LF
+electrode NOUN I-LF
+location NOUN I-LF
+; PUNCT B-O
+rTMS PROPN B-AC
+, PUNCT B-O
+repetitive ADJ B-LF
+transcranial ADJ I-LF
+magnetic ADJ I-LF
+stimulation NOUN I-LF
+. PUNCT B-O
+
+SFM PROPN B-AC
+shows VERB B-O
+result NOUN B-O
+of ADP B-O
+serum NOUN B-LF
+free ADJ I-LF
+medium NOUN I-LF
+alone ADV B-O
+( PUNCT B-O
+baseline NOUN B-O
+control NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+thalamus NOUN B-O
+expression NOUN B-O
+domain NOUN B-O
+of ADP B-O
+lhx9 NOUN B-O
+overlaps VERB B-O
+with ADP B-O
+the DET B-O
+pattern NOUN B-O
+of ADP B-O
+id2a NOUN B-O
+in ADP B-O
+the DET B-O
+medial ADJ B-O
+part NOUN B-O
+of ADP B-O
+the DET B-O
+mantle NOUN B-LF
+zone NOUN I-LF
+( PUNCT B-O
+g NOUN B-O
+, PUNCT B-O
+g′ NOUN B-O
+, PUNCT B-O
+black ADJ B-O
+bar NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+lef1 NOUN B-O
+as ADP B-O
+a DET B-O
+marker NOUN B-O
+of ADP B-O
+post ADJ B-O
+- NOUN B-O
+mitotic ADJ B-O
+thalamic ADJ B-O
+neurons NOUN B-O
+shows VERB B-O
+co NOUN B-O
+- NOUN B-O
+expression NOUN B-O
+with ADP B-O
+lhx9 NOUN B-O
+in ADP B-O
+the DET B-O
+MZ PROPN B-AC
+( PUNCT B-O
+i NOUN B-O
+, PUNCT B-O
+i′ NOUN B-O
+; PUNCT B-O
+black ADJ B-O
+bar NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Two NUM B-O
+- PUNCT B-O
+month NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+Thy1 PROPN B-O
+- PUNCT B-O
+YFP PROPN B-AC
+transgenic VERB B-O
+mice NOUN B-O
+expressing VERB B-O
+yellow ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+YFP PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+layer NOUN B-LF
+5 NUM I-LF
+( PUNCT B-O
+L5 PROPN B-AC
+) PUNCT B-O
+pyramidal ADJ B-O
+neurons NOUN B-O
+were AUX B-O
+repeatedly ADV B-O
+imaged VERB B-O
+before ADP B-O
+and CCONJ B-O
+1 NUM B-O
+to ADP B-O
+4 NUM B-O
+weeks NOUN B-O
+after ADP B-O
+peripheral ADJ B-O
+nerve NOUN B-O
+injury NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+3A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+region NOUN B-O
+of ADP B-O
+S1 PROPN B-AC
+corresponding VERB B-O
+to ADP B-O
+the DET B-O
+SNI PROPN B-AC
+surgery NOUN B-O
+side NOUN B-O
+, PUNCT B-O
+we PRON B-O
+found VERB B-O
+a DET B-O
+significant ADJ B-O
+increase NOUN B-O
+in ADP B-O
+the DET B-O
+elimination NOUN B-O
+and CCONJ B-O
+formation NOUN B-O
+rates NOUN B-O
+of ADP B-O
+dendritic ADJ B-O
+spines NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+3B NUM B-O
+and CCONJ B-O
+3C NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Within ADP B-O
+the DET B-O
+first ADJ B-O
+week NOUN B-O
+after ADP B-O
+surgery NOUN B-O
+, PUNCT B-O
+7.7 NUM B-O
+± SYM B-O
+0.6 NUM B-O
+% NOUN B-O
+of ADP B-O
+dendritic ADJ B-O
+spines NOUN B-O
+were AUX B-O
+eliminated VERB B-O
+and CCONJ B-O
+8.1 NUM B-O
+± SYM B-O
+0.5 NUM B-O
+% NOUN B-O
+were AUX B-O
+formed VERB B-O
+in ADP B-O
+sham ADJ B-O
+mice NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+11.4 NUM B-O
+± SYM B-O
+1.1 NUM B-O
+% NOUN B-O
+and CCONJ B-O
+11.9 NUM B-O
+± SYM B-O
+1.1 NUM B-O
+% NOUN B-O
+of ADP B-O
+dendritic ADJ B-O
+spines NOUN B-O
+were AUX B-O
+eliminated VERB B-O
+and CCONJ B-O
+formed VERB B-O
+in ADP B-O
+SNI PROPN B-AC
+mice NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+Inhibitor-2 NOUN B-LF
+( PUNCT B-O
+I-2 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+highly ADV B-O
+conserved ADJ B-O
+protein NOUN B-O
+, PUNCT B-O
+interacts VERB B-O
+with ADP B-O
+the DET B-O
+catalytic ADJ B-O
+subunit NOUN B-O
+of ADP B-O
+protein NOUN B-LF
+phosphatase NOUN I-LF
+1 NUM I-LF
+( PUNCT B-O
+PP1 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+inhibits VERB B-O
+its PRON B-O
+catalytic ADJ B-O
+activity NOUN B-O
+in ADP B-O
+vitro ADV B-O
+[ PUNCT B-O
+33 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+HR NOUN B-O
+, PUNCT B-O
+Heart NOUN B-O
+Rate NOUN B-O
+; PUNCT B-O
+SBP PROPN B-O
+, PUNCT B-O
+Systolic ADJ B-O
+Blood NOUN B-O
+Pressure NOUN B-O
+; PUNCT B-O
+DBP NOUN B-O
+, PUNCT B-O
+Diastolic ADJ B-O
+Blood NOUN B-O
+Pressure NOUN B-O
+; PUNCT B-O
+PP NOUN B-O
+, PUNCT B-O
+Pulse NOUN B-O
+Pressure NOUN B-O
+; PUNCT B-O
+FFR PROPN B-AC
+, PUNCT B-O
+Fractional ADJ B-LF
+Flow PROPN I-LF
+reserve NOUN I-LF
+; PUNCT B-O
+CFVR PROPN B-AC
+, PUNCT B-O
+Coronary ADJ B-LF
+Flow PROPN I-LF
+Velocity PROPN I-LF
+Reserve PROPN I-LF
+; PUNCT B-O
+sFCW PROPN B-AC
+, PUNCT B-O
+systolic ADJ B-LF
+Forward ADJ I-LF
+travelling VERB I-LF
+Compression NOUN I-LF
+Wave PROPN I-LF
+; PUNCT B-O
+dBEW PROPN B-AC
+, PUNCT B-O
+diastolic ADJ B-LF
+Backward ADJ I-LF
+travelling VERB I-LF
+Expansion NOUN I-LF
+Wave PROPN I-LF
+( PUNCT B-O
+Table PROPN B-O
+C PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Univariate ADJ B-O
+linear ADJ B-O
+regression NOUN B-O
+analyses NOUN B-O
+of ADP B-O
+baseline ADJ B-O
+( PUNCT B-O
+pre ADJ B-O
+- ADJ B-O
+PCI PROPN B-AC
+) PUNCT B-O
+sFCW PROPN B-AC
+and CCONJ B-O
+dBEW PROPN B-AC
+cumulative ADJ B-O
+intensity NOUN B-O
+with ADP B-O
+baseline ADJ B-O
+haemodynamic ADJ B-O
+and CCONJ B-O
+patient ADJ B-O
+variables NOUN B-O
+. PUNCT B-O
+
+FRET PROPN B-AC
+, PUNCT B-O
+Förster PROPN B-LF
+resonance NOUN I-LF
+energy NOUN I-LF
+transfer NOUN I-LF
+; PUNCT B-O
+GP PROPN B-AC
+, PUNCT B-O
+EBOV NOUN B-LF
+envelope NOUN I-LF
+EBOV PROPN B-AC
+glycoprotein NOUN I-LF
+; PUNCT B-O
+GPΔmuc PROPN B-AC
+, PUNCT B-O
+GP PROPN B-LF
+with ADP I-LF
+GP PROPN B-AC
+the DET I-LF
+mucin NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+domain NOUN I-LF
+deleted VERB I-LF
+; PUNCT B-O
+MD PROPN B-AC
+, PUNCT B-O
+molecular ADJ B-LF
+dynamics NOUN I-LF
+. PUNCT B-O
+
+The DET B-O
+apparent ADJ B-LF
+digestibility NOUN I-LF
+coefficients NOUN I-LF
+( PUNCT B-O
+ADCs PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+DM PROPN B-AC
+, PUNCT B-O
+protein NOUN B-O
+, PUNCT B-O
+lipid NOUN B-O
+, PUNCT B-O
+ash NOUN B-O
+and CCONJ B-O
+energy NOUN B-O
+were AUX B-O
+calculated VERB B-O
+using VERB B-O
+the DET B-O
+following VERB B-O
+equation NOUN B-O
+[ X B-O
+25 NUM B-O
+] PUNCT B-O
+: PUNCT B-O
+ADCnutrientorenergy=[1−(Markerfeed×NutrientfaecesMarkerfaeces×Nutrientfeed)]×100(1 X B-O
+) PUNCT B-O
+ADCdry ADJ B-O
+matter=[1−(MarkerfeedMarkerfaeces)]×100(2 X B-O
+) PUNCT B-O
+where SCONJ B-O
+Markerfeed PROPN B-O
+and CCONJ B-O
+Markerfaeces NOUN B-O
+are AUX B-O
+the DET B-O
+contents NOUN B-O
+of ADP B-O
+the DET B-O
+marker NOUN B-O
+( PUNCT B-O
+% PUNCT B-O
+dry ADJ B-LF
+matter NOUN I-LF
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+feed NOUN B-O
+and CCONJ B-O
+faeces NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+Nutrientfeed PROPN B-O
+and CCONJ B-O
+Nutrientfaeces PROPN B-O
+are AUX B-O
+the DET B-O
+nutrient NOUN B-O
+contents NOUN B-O
+( PUNCT B-O
+% PUNCT B-O
+dry ADJ B-LF
+matter NOUN I-LF
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+feed NOUN B-O
+and CCONJ B-O
+faeces NOUN B-O
+. PUNCT B-O
+
+Excess ADJ B-LF
+lung NOUN I-LF
+weight NOUN I-LF
+( PUNCT B-O
+ELW PROPN B-AC
+) PUNCT B-O
+showed VERB B-O
+highly ADV B-O
+significant ADJ B-O
+correlation NOUN B-O
+with ADP B-O
+parameters NOUN B-O
+describing VERB B-O
+inflation NOUN B-O
+( PUNCT B-O
+inflated VERB B-O
+lung NOUN B-O
+tissue NOUN B-O
+[ X B-O
+% X B-O
+] X B-O
+p NOUN B-O
+= SYM B-O
+0.0001 NUM B-O
+r NOUN B-O
+= SYM B-O
+-0.65 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+haemodynamics NOUN B-O
+( PUNCT B-O
+SOFA_cv NOUN B-O
+mean NOUN B-O
+p NOUN B-O
+= SYM B-O
+0.03 NUM B-O
+r NOUN B-O
+= SYM B-O
+0.41 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+applied VERB B-O
+ventilation NOUN B-O
+pressures NOUN B-O
+( PUNCT B-O
+PEEP PROPN B-AC
+[ X B-O
+mmHg X B-O
+] X B-O
+p NOUN B-O
+= SYM B-O
+0.05 NUM B-O
+r NOUN B-O
+= SYM B-O
+0.37 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+do VERB B-O
+so ADV B-O
+we PRON B-O
+apply VERB B-O
+descriptive ADJ B-O
+statistics NOUN B-O
+and CCONJ B-O
+conduct VERB B-O
+logistic ADJ B-O
+and CCONJ B-O
+multinomial ADJ B-O
+regressions NOUN B-O
+using VERB B-O
+data NOUN B-O
+from ADP B-O
+the DET B-O
+Service PROPN B-LF
+Provision PROPN I-LF
+Assessment PROPN I-LF
+( PUNCT B-O
+SPA PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+the DET B-O
+Demographic PROPN B-LF
+and CCONJ I-LF
+Health PROPN I-LF
+Surveys PROPN I-LF
+( PUNCT B-O
+DHS PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+all DET B-O
+health NOUN B-O
+facilities NOUN B-O
+in ADP B-O
+Malawi PROPN B-O
+in ADP B-O
+2013/2014 NUM B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+CABG PROPN B-AC
+, PUNCT B-O
+coronary ADJ B-LF
+artery NOUN I-LF
+bypass NOUN I-LF
+grift NOUN I-LF
+; PUNCT B-O
+PTCA PROPN B-AC
+, PUNCT B-O
+percutaneous ADJ B-LF
+transluminal ADJ I-LF
+coronary ADJ I-LF
+angioplasty NOUN I-LF
+; PUNCT B-O
+ACE PROPN B-AC
+: PUNCT B-O
+Angiotensin NOUN B-LF
+converting VERB I-LF
+enzyme NOUN I-LF
+. PUNCT B-O
+
+Consignments NOUN B-O
+with ADP B-O
+one NUM B-O
+or CCONJ B-O
+more ADJ B-O
+“ PUNCT B-O
+POS PROPN B-AC
+” PUNCT B-O
+samples NOUN B-O
+were AUX B-O
+classified VERB B-O
+as ADP B-O
+OJD PROPN B-AC
+“ PUNCT B-O
+Positive ADJ B-LF
+” PUNCT B-O
+. PUNCT B-O
+
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+RNAi PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT B-O
+TOR PROPN B-AC
+, PUNCT B-O
+Target NOUN B-LF
+of ADP I-LF
+Rapamycin PROPN I-LF
+; PUNCT B-O
+tub NOUN B-O
+. PUNCT B-O
+
+Gal4 NOUN B-O
+, PUNCT B-O
+tubulin NOUN B-O
+. PUNCT B-O
+
+Gal4 NOUN B-O
+; PUNCT B-O
+UAS PROPN B-AC
+, PUNCT B-O
+Upstream PROPN B-LF
+activator NOUN I-LF
+sequence NOUN I-LF
+; PUNCT B-O
+Yki PROPN B-AC
+, PUNCT B-O
+Yorkie PROPN B-LF
+. PUNCT B-O
+
+The DET B-O
+Italian ADJ B-LF
+Liver PROPN I-LF
+Cancer PROPN I-LF
+( PUNCT B-O
+ITA.LI.CA PROPN B-AC
+) PUNCT B-O
+dataset NOUN B-O
+, PUNCT B-O
+including VERB B-O
+more ADJ B-O
+than ADP B-O
+5,000 NUM B-O
+Italian ADJ B-O
+HCC PROPN B-AC
+patients NOUN B-O
+prospectively ADV B-O
+enrolled VERB B-O
+from ADP B-O
+1 NUM B-O
+January PROPN B-O
+1987 NUM B-O
+to ADP B-O
+31 NUM B-O
+March PROPN B-O
+2012 NUM B-O
+, PUNCT B-O
+was AUX B-O
+used VERB B-O
+for ADP B-O
+the DET B-O
+training NOUN B-O
+and CCONJ B-O
+internal ADJ B-O
+validation NOUN B-O
+sets NOUN B-O
+. PUNCT B-O
+
+Schisandra PROPN B-LF
+chinensis PROPN I-LF
+( PUNCT B-O
+SC PROPN B-AC
+) PUNCT B-O
+has VERB B-O
+a DET B-O
+long ADJ B-O
+history NOUN B-O
+as ADP B-O
+a DET B-O
+medicinal ADJ B-O
+herb NOUN B-O
+and CCONJ B-O
+is AUX B-O
+a DET B-O
+traditional ADJ B-O
+component NOUN B-O
+in ADP B-O
+oriental ADJ B-O
+medicines NOUN B-O
+[ PUNCT B-O
+19,20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Astrocytes NOUN B-LF
+aged VERB I-LF
+seven NUM I-LF
+days NOUN I-LF
+( PUNCT B-O
+E7 PROPN B-AC
+) PUNCT B-O
+showed VERB B-O
+increased VERB B-O
+proliferation NOUN B-O
+and CCONJ B-O
+diminished ADJ B-O
+differentiation NOUN B-O
+, PUNCT B-O
+while SCONJ B-O
+21 NUM B-O
+- PUNCT B-O
+day NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+( PUNCT B-O
+E21 PROPN B-AC
+) PUNCT B-O
+astrocytes NOUN B-O
+depicted VERB B-O
+reversed VERB B-O
+effects NOUN B-O
+. PUNCT B-O
+
+ARE PROPN B-AC
+, PUNCT B-O
+antioxidant ADJ B-LF
+response NOUN I-LF
+element NOUN I-LF
+; PUNCT B-O
+IHC PROPN B-O
+, PUNCT B-O
+immunohistochemical NOUN B-O
+; PUNCT B-O
+MEF PROPN B-AC
+, PUNCT B-O
+mouse NOUN B-LF
+embryonic ADJ I-LF
+fibroblast NOUN I-LF
+; PUNCT B-O
+NRF2 PROPN B-AC
+, PUNCT B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+- PUNCT I-LF
+erythroid NOUN I-LF
+2 NUM I-LF
+- PUNCT I-LF
+like ADJ I-LF
+2 NUM I-LF
+; PUNCT B-O
+PTCH1 PROPN B-AC
+, PUNCT B-O
+Patched VERB B-LF
+1 NUM I-LF
+Reviewer NOUN B-O
+# NOUN B-O
+3 NUM B-O
+: PUNCT B-O
+In ADP B-O
+this DET B-O
+randomized ADJ B-O
+controlled VERB B-O
+trial NOUN B-O
+, PUNCT B-O
+the DET B-O
+Vienna PROPN B-LF
+Prediction PROPN I-LF
+Model PROPN I-LF
+( PUNCT B-O
+VPM PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+tested VERB B-O
+to ADP B-O
+determine VERB B-O
+whether SCONJ B-O
+implementing VERB B-O
+the DET B-O
+model NOUN B-O
+would AUX B-O
+reduce VERB B-O
+recurrence NOUN B-O
+risk NOUN B-O
+. PUNCT B-O
+
+883 NUM B-O
+patients NOUN B-O
+were AUX B-O
+randomised VERB B-O
+to ADP B-O
+using VERB B-O
+the DET B-O
+VPM PROPN B-AC
+compared VERB B-O
+with ADP B-O
+usual ADJ B-O
+care NOUN B-O
+. PUNCT B-O
+
+While SCONJ B-O
+various ADJ B-O
+cytokines NOUN B-O
+and CCONJ B-O
+growth NOUN B-O
+factors NOUN B-O
+are AUX B-O
+considered VERB B-O
+to ADP B-O
+contribute VERB B-O
+to ADP B-O
+skin NOUN B-O
+fibroblast NOUN B-O
+activation NOUN B-O
+in ADP B-O
+scleroderma NOUN B-O
+, PUNCT B-O
+transforming VERB B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+- PUNCT I-LF
+β PUNCT I-LF
+( PUNCT B-O
+TGF-β PROPN B-AC
+) PUNCT B-O
+plays VERB B-O
+an DET B-O
+important ADJ B-O
+role NOUN B-O
+in ADP B-O
+the DET B-O
+fibrotic ADJ B-O
+reaction NOUN B-O
+of ADP B-O
+scleroderma NOUN B-O
+pathology NOUN B-O
+[ X B-O
+5 NUM B-O
+, PUNCT B-O
+6 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Additionally ADV B-O
+, PUNCT B-O
+the DET B-O
+latest ADJ B-O
+2020 NUM B-O
+ESC PROPN B-O
+Acute ADJ B-O
+Coronary ADJ B-O
+Syndromes PROPN B-O
+( PUNCT B-O
+ACS PROPN B-O
+) PUNCT B-O
+in ADP B-O
+Patients NOUN B-O
+Presenting VERB B-O
+without ADP B-O
+Persistent ADJ B-O
+ST ADJ B-O
+- PUNCT B-O
+Segment PROPN B-O
+Elevation PROPN B-O
+( PUNCT B-O
+Management NOUN B-O
+of ADP B-O
+) PUNCT B-O
+Guidelines PROPN B-O
+recommend VERB B-O
+complete ADJ B-O
+revascularization NOUN B-O
+in ADP B-O
+non ADJ B-O
+- PUNCT B-O
+ST ADJ B-O
+- PUNCT B-O
+elevation ADJ B-O
+acute ADJ B-O
+coronary ADJ B-O
+syndrome NOUN B-O
+( PUNCT B-O
+NSTE PROPN B-O
+- PUNCT B-O
+ACS PROPN B-O
+) PUNCT B-O
+patients NOUN B-O
+without ADP B-O
+cardiogenic ADJ B-O
+shock NOUN B-O
+and CCONJ B-O
+with ADP B-O
+MV PROPN B-O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+CAD PROPN B-AC
+) PUNCT B-O
+but CCONJ B-O
+offer VERB B-O
+no DET B-O
+recommendations NOUN B-O
+for ADP B-O
+patients NOUN B-O
+with ADP B-O
+severe ADJ B-O
+LVSD NOUN B-O
+[ PUNCT B-O
+12 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+have AUX B-O
+previously ADV B-O
+described VERB B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+the DET B-O
+complement NOUN B-O
+- PUNCT B-O
+regulating VERB B-O
+protein NOUN B-O
+salivary ADJ B-LF
+scavenger NOUN I-LF
+and CCONJ I-LF
+agglutinin NOUN I-LF
+( PUNCT B-O
+SALSA PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+amniotic ADJ B-O
+fluid NOUN B-O
+. PUNCT B-O
+
+Their PRON B-O
+serum NOUN B-O
+samples NOUN B-O
+were AUX B-O
+extracted VERB B-O
+from ADP B-O
+a DET B-O
+population NOUN B-O
+- PUNCT B-O
+representative ADJ B-O
+biobank NOUN B-O
+, PUNCT B-O
+the DET B-O
+Finnish PROPN B-LF
+Maternity PROPN I-LF
+Cohort PROPN I-LF
+( PUNCT B-O
+FMC PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+18,21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Previous ADJ B-O
+studies NOUN B-O
+of ADP B-O
+ischemia NOUN B-LF
+- ADJ I-LF
+reperfusion NOUN I-LF
+injury NOUN I-LF
+( PUNCT B-O
+IRI PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+hearts NOUN B-O
+from ADP B-O
+mice NOUN B-O
+with ADP B-O
+cardiac NOUN B-O
+- ADJ B-O
+restricted VERB B-O
+overexpression NOUN B-O
+of ADP B-O
+CCN2 PROPN B-O
+have AUX B-O
+shown VERB B-O
+that SCONJ B-O
+CCN2 PROPN B-O
+increases VERB B-O
+tolerance NOUN B-O
+towards ADP B-O
+IRI PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+objectives NOUN B-O
+of ADP B-O
+this DET B-O
+study NOUN B-O
+were AUX B-O
+to PART B-O
+investigate VERB B-O
+to PART B-O
+what DET B-O
+extent NOUN B-O
+post ADJ B-O
+- ADJ B-O
+ischemic ADJ B-O
+administration NOUN B-O
+of ADP B-O
+recombinant ADJ B-O
+human ADJ B-O
+CCN2 PROPN B-O
+( PUNCT B-O
+rhCCN2 PROPN B-AC
+) PUNCT B-O
+would AUX B-O
+limit VERB B-O
+infarct ADJ B-O
+size NOUN B-O
+and CCONJ B-O
+improve VERB B-O
+functional ADJ B-O
+recovery NOUN B-O
+and CCONJ B-O
+what DET B-O
+signaling NOUN B-O
+pathways NOUN B-O
+are AUX B-O
+involved VERB B-O
+. PUNCT B-O
+
+Type NOUN B-O
+I NUM B-O
+methanotrophs NOUN B-O
+( PUNCT B-O
+including VERB B-O
+Methylococcus PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+are AUX B-O
+all PRON B-O
+members NOUN B-O
+of ADP B-O
+the DET B-O
+Gammaproteobacteria NOUN B-O
+, PUNCT B-O
+utilize VERB B-O
+ribulose NOUN B-LF
+monophosphate NOUN I-LF
+( PUNCT B-O
+RuMP PROPN B-AC
+) PUNCT B-O
+as ADP B-O
+the DET B-O
+primary ADJ B-O
+pathway NOUN B-O
+for ADP B-O
+formaldehyde NOUN B-O
+assimilation NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+those PRON B-O
+of ADP B-O
+type NOUN B-O
+II NUM B-O
+, PUNCT B-O
+which PRON B-O
+are AUX B-O
+all PRON B-O
+Alphaproteobacteria NOUN B-O
+, PUNCT B-O
+use VERB B-O
+the DET B-O
+serine ADJ B-O
+pathway NOUN B-O
+( PUNCT B-O
+Hanson PROPN B-O
+and CCONJ B-O
+Hanson PROPN B-O
+1996 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+For ADP B-O
+SNP PROPN B-AC
+validation NOUN B-O
+statistics NOUN B-O
+using VERB B-O
+a DET B-O
+Markov PROPN B-O
+chain NOUN B-O
+method NOUN B-O
+, PUNCT B-O
+the DET B-O
+selected VERB B-O
+SNP PROPN B-AC
+markers NOUN B-O
+were AUX B-O
+further ADV B-O
+examined VERB B-O
+by ADP B-O
+testing VERB B-O
+the DET B-O
+deviation NOUN B-O
+from ADP B-O
+Hardy PROPN B-LF
+Weinberg PROPN I-LF
+equilibrium NOUN I-LF
+( PUNCT B-O
+HWE PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+each DET B-O
+SNP PROPN B-AC
+locus NOUN B-O
+( PUNCT B-O
+S62 PROPN B-O
+Table NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+for ADP B-O
+each DET B-O
+breed NOUN B-O
+population NOUN B-O
+( PUNCT B-O
+S63 PROPN B-O
+Table NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Those DET B-O
+individuals NOUN B-O
+who PRON B-O
+participated VERB B-O
+in ADP B-O
+an DET B-O
+external ADJ B-LF
+quality NOUN I-LF
+assurance NOUN I-LF
+( PUNCT B-O
+EQA PROPN B-AC
+) PUNCT B-O
+program NOUN B-O
+accounted VERB B-O
+for ADP B-O
+36(60 NUM B-O
+% NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Table NOUN B-O
+1 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+the DET B-O
+Swedish ADJ B-O
+study NOUN B-O
+of ADP B-O
+Rai PROPN B-O
+et PROPN B-O
+al.[11 X B-O
+] X B-O
+reported VERB B-O
+a DET B-O
+clear ADJ B-O
+increase NOUN B-O
+in ADP B-O
+prevalence NOUN B-O
+in ADP B-O
+the DET B-O
+most ADV B-O
+deprived ADJ B-O
+backgrounds NOUN B-O
+even ADV B-O
+after ADP B-O
+taking VERB B-O
+into ADP B-O
+account NOUN B-O
+other ADJ B-O
+associated VERB B-O
+factors NOUN B-O
+and CCONJ B-O
+for ADP B-O
+all DET B-O
+cases NOUN B-O
+of ADP B-O
+ASD PROPN B-AC
+studied VERB B-O
+i.e. X B-O
+with ADP B-O
+or CCONJ B-O
+without ADP B-O
+associated VERB B-O
+intellectual ADJ B-LF
+disability NOUN I-LF
+( PUNCT B-O
+ID PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+comparison NOUN B-O
+of ADP B-O
+comorbidities NOUN B-O
+recorded VERB B-O
+through ADP B-O
+HES PROPN B-AC
+with ADP B-O
+those PRON B-O
+from ADP B-O
+primary ADJ B-O
+care NOUN B-O
+records NOUN B-O
+( PUNCT B-O
+clinical ADJ B-LF
+practice NOUN I-LF
+research NOUN I-LF
+database NOUN I-LF
+, PUNCT B-O
+CPRD PROPN B-AC
+) PUNCT B-O
+found VERB B-O
+that SCONJ B-O
+CPRD PROPN B-AC
+recorded VERB B-O
+more ADJ B-O
+comorbidity NOUN B-O
+than ADP B-O
+HES PROPN B-AC
+, PUNCT B-O
+but CCONJ B-O
+this PRON B-O
+did AUX B-O
+not PART B-O
+adversely ADV B-O
+affect VERB B-O
+their PRON B-O
+models NOUN B-O
+of ADP B-O
+mortality NOUN B-O
+risk NOUN B-O
+after ADP B-O
+gastrointestinal ADJ B-O
+bleeding NOUN B-O
+or CCONJ B-O
+diabetes NOUN B-O
+[ PUNCT B-O
+24 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In SCONJ B-O
+order NOUN B-O
+to PART B-O
+examine VERB B-O
+whether SCONJ B-O
+ID PROPN B-AC
+is AUX B-O
+related VERB B-O
+with ADP B-O
+children NOUN B-O
+with ADP B-O
+hypothyroidism NOUN B-O
+or CCONJ B-O
+with ADP B-O
+low ADJ B-O
+income NOUN B-O
+, PUNCT B-O
+multivariable ADJ B-O
+analyses NOUN B-O
+were AUX B-O
+performed VERB B-O
+using VERB B-O
+Cox PROPN B-O
+proportional ADJ B-O
+hazards NOUN B-O
+models NOUN B-O
+to PART B-O
+calculate VERB B-O
+adjusted VERB B-O
+hazard NOUN B-LF
+ratios NOUN I-LF
+( PUNCT B-O
+HRs PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+intervals NOUN I-LF
+[ PUNCT B-O
+CIs PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+as ADP B-O
+an DET B-O
+estimate NOUN B-O
+of ADP B-O
+the DET B-O
+relative ADJ B-O
+rate NOUN B-O
+of ADP B-O
+ID PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+proportionality NOUN B-O
+assumption NOUN B-O
+was AUX B-O
+tested VERB B-O
+by ADP B-O
+plotting VERB B-O
+Schoenfeld PROPN B-O
+- PUNCT B-O
+like ADJ B-O
+residuals NOUN B-O
+. PUNCT B-O
+
+This DET B-O
+pathway NOUN B-O
+directly ADV B-O
+controls VERB B-O
+the DET B-O
+expression NOUN B-O
+of ADP B-O
+many ADJ B-O
+cell NOUN B-O
+- PUNCT B-O
+cycle NOUN B-O
+genes NOUN B-O
+and CCONJ B-O
+plays VERB B-O
+a DET B-O
+key ADJ B-O
+role NOUN B-O
+in ADP B-O
+embryonic ADJ B-LF
+stem NOUN I-LF
+cell NOUN I-LF
+( PUNCT B-O
+ESC PROPN B-AC
+) PUNCT B-O
+self NOUN B-O
+- PUNCT B-O
+renewal NOUN B-O
+[ PUNCT B-O
+37–39,54,55 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+are AUX B-O
+presented VERB B-O
+as ADP B-O
+mean ADJ B-LF
+fluorescence NOUN I-LF
+intensity NOUN I-LF
+( PUNCT B-O
+MFI PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+MFI PROPN B-AC
+was AUX B-O
+determined VERB B-O
+by ADP B-O
+FlowJo PROPN B-O
+Software PROPN B-O
+( PUNCT B-O
+TreeStar PROPN B-O
+, PUNCT B-O
+Ashland PROPN B-O
+, PUNCT B-O
+OR PROPN B-O
+, PUNCT B-O
+USA PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+line NOUN B-O
+in ADP B-O
+the DET B-O
+middle NOUN B-O
+represents VERB B-O
+the DET B-O
+median ADJ B-O
+value NOUN B-O
+. PUNCT B-O
+
+One NUM B-O
+such ADJ B-O
+insecticide NOUN B-O
+is AUX B-O
+pyriproxyfen NOUN B-LF
+( PUNCT B-O
+PPF PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+an DET B-O
+insect NOUN B-O
+juvenile ADJ B-O
+hormone NOUN B-O
+analogue NOUN B-O
+that PRON B-O
+kills VERB B-O
+mosquito NOUN B-O
+juveniles NOUN B-O
+at ADP B-O
+minute ADJ B-O
+doses NOUN B-O
+and CCONJ B-O
+can AUX B-O
+safely ADV B-O
+be AUX B-O
+used VERB B-O
+even ADV B-O
+in ADP B-O
+drinking NOUN B-O
+water NOUN B-O
+[ PUNCT B-O
+3,27,28 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Of ADP B-O
+the DET B-O
+22 NUM B-O
+studies NOUN B-O
+providing VERB B-O
+results NOUN B-O
+from ADP B-O
+human ADJ B-LF
+immunodeficiency NOUN I-LF
+virus NOUN I-LF
+( PUNCT B-O
+HIV)-testing PROPN B-AC
+, PUNCT B-O
+12 NUM B-O
+( PUNCT B-O
+55 NUM B-O
+% PUNCT B-O
+) PUNCT B-O
+reported VERB B-O
+HIV PROPN B-AC
+prevalence NOUN B-O
+greater ADJ B-O
+than ADP B-O
+50%[39,40,42,43,45–49,55,59 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+investigate VERB B-O
+whether SCONJ B-O
+spz5 PROPN B-O
+has VERB B-O
+neurotrophic ADJ B-O
+function NOUN B-O
+we PRON B-O
+first ADV B-O
+visualised VERB B-O
+its PRON B-O
+expression NOUN B-O
+pattern NOUN B-O
+. PUNCT B-O
+
+spz5 PROPN B-O
+is AUX B-O
+expressed VERB B-O
+at ADP B-O
+the DET B-O
+embryonic ADJ B-O
+CNS PROPN B-AC
+midline NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+8C NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+muscles NOUN B-O
+( PUNCT B-O
+Figure PROPN B-O
+9A NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+in ADP B-O
+the DET B-O
+epidermis NOUN B-O
+( PUNCT B-O
+unpublished ADJ B-O
+data NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+the DET B-O
+embryonic ADJ B-O
+head NOUN B-O
+peripheral ADJ B-LF
+nervous ADJ I-LF
+system NOUN I-LF
+( PUNCT B-O
+PNS PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+unpublished ADJ B-O
+data NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+drug NOUN B-O
+was AUX B-O
+applied VERB B-O
+to ADP B-O
+the DET B-O
+skin NOUN B-O
+daily ADV B-O
+for ADP B-O
+5 NUM B-O
+days NOUN B-LF
+( PUNCT B-O
+5 NUM B-O
+d PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+for ADP B-O
+12 NUM B-O
+days NOUN B-LF
+( PUNCT B-O
+1 NUM B-O
+, PUNCT B-O
+2 NUM B-O
+, PUNCT B-O
+3 NUM B-O
+, PUNCT B-O
+4 NUM B-O
+, PUNCT B-O
+5 NUM B-O
+, PUNCT B-O
+8 NUM B-O
+, PUNCT B-O
+9 NUM B-O
+, PUNCT B-O
+10 NUM B-O
+, PUNCT B-O
+11 NUM B-O
+, PUNCT B-O
+12th ADJ B-O
+day NOUN B-LF
+) PUNCT B-O
+( PUNCT B-O
+12d NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+routing NOUN B-O
+of ADP B-O
+DNA NOUN B-O
+through ADP B-O
+the DET B-O
+double ADJ B-O
+hexamers NOUN B-O
+is AUX B-O
+unclear ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+none NOUN B-O
+of ADP B-O
+the DET B-O
+high ADJ B-O
+- PUNCT B-O
+resolution NOUN B-O
+structures NOUN B-O
+of ADP B-O
+T-ag PROPN B-AC
+to ADP B-O
+date NOUN B-O
+have AUX B-O
+included VERB B-O
+DNA NOUN B-O
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+the DET B-O
+recent ADJ B-O
+structure NOUN B-O
+of ADP B-O
+the DET B-O
+BPV PROPN B-AC
+initiator NOUN B-O
+E1 NOUN B-O
+helicase NOUN B-O
+domain NOUN B-O
+shows VERB B-O
+that SCONJ B-O
+E1 NOUN B-O
+forms VERB B-O
+a DET B-O
+hexameric ADJ B-O
+ring NOUN B-O
+which PRON B-O
+contains VERB B-O
+single ADJ B-LF
+- PUNCT I-LF
+stranded ADJ I-LF
+DNA NOUN I-LF
+( PUNCT B-O
+ssDNA PROPN B-AC
+) PUNCT B-O
+within ADP B-O
+its PRON B-O
+central ADJ B-O
+channel NOUN B-O
+[ PUNCT B-O
+20 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+“ PUNCT B-O
+Rabbit PROPN B-O
+ear NOUN B-O
+” PUNCT B-O
+protrusions NOUN B-O
+emanating VERB B-O
+from ADP B-O
+the DET B-O
+dodecameric ADJ B-O
+T PROPN B-AC
+complex NOUN B-O
+have AUX B-O
+been AUX B-O
+observed VERB B-O
+on ADP B-O
+electron NOUN B-O
+microscopy NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+these DET B-O
+protrusions NOUN B-O
+have AUX B-O
+been AUX B-O
+attributed VERB B-O
+to ADP B-O
+-agssDNA PROPN B-AC
+coated VERB B-O
+by ADP B-O
+RPA PROPN B-AC
+[ PUNCT B-O
+21 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+tested VERB B-O
+nonactivated ADJ B-O
+and CCONJ B-O
+PHA PROPN B-O
+- PUNCT B-O
+activated VERB B-O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT B-O
+PBMCs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+as ADP B-O
+well ADV B-O
+as ADP B-O
+purified VERB B-O
+cell NOUN B-O
+subsets NOUN B-O
+, PUNCT B-O
+including VERB B-O
+CD14 NOUN B-O
++ NOUN B-O
+monocytes NOUN B-O
+, PUNCT B-O
+activated VERB B-O
+CD4 NOUN B-O
++ NOUN B-O
+T NOUN B-O
+cells NOUN B-O
+, PUNCT B-O
+immature ADJ B-O
+and CCONJ B-O
+mature ADJ B-O
+monocyte NOUN B-O
+- PUNCT B-O
+derived VERB B-O
+dendritic ADJ B-LF
+cells NOUN I-LF
+( PUNCT B-O
+DCs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+LASSO PROPN B-AC
+= PUNCT B-O
+least ADJ B-LF
+absolute ADJ I-LF
+shrinkage NOUN I-LF
+and CCONJ I-LF
+selection NOUN I-LF
+operator NOUN I-LF
+. PUNCT B-O
+
+Parent(s)/legal NOUN B-O
+authorized ADJ B-O
+representatives NOUN B-O
+also ADV B-O
+provided VERB B-O
+current ADJ B-O
+inhaled VERB B-LF
+corticosteroid NOUN I-LF
+( PUNCT B-O
+ICS PROPN B-AC
+) PUNCT B-O
+controller NOUN B-O
+medication NOUN B-O
+( PUNCT B-O
+Asmanex PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+Flovent PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+Qvar PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+Pulmicort PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+Advair PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+Dulera PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+Symbicort PROPN B-O
+® PUNCT B-O
+, PUNCT B-O
+etc X B-O
+. PUNCT B-O
+
+) PUNCT B-O
+. PUNCT B-O
+
+For ADP B-O
+transmission NOUN B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT B-O
+TEM PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+specimens NOUN B-O
+were AUX B-O
+then ADV B-O
+washed VERB B-O
+3×20 NUM B-O
+min NOUN B-O
+in ADP B-O
+the DET B-O
+same ADJ B-O
+buffer NOUN B-O
+as SCONJ B-O
+used VERB B-O
+for ADP B-O
+fixation NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+post VERB B-O
+- VERB B-O
+fixed VERB B-O
+in ADP B-O
+1–2 NUM B-O
+% NOUN B-O
+osmium NOUN B-O
+tetroxide NOUN B-O
+( PUNCT B-O
+OsO4 NOUN B-O
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+same ADJ B-O
+buffer NOUN B-O
+for ADP B-O
+1–3 NUM B-O
+h. NOUN B-O
+According VERB B-O
+to ADP B-O
+projection NOUN B-O
+of ADP B-O
+Central PROPN B-LF
+Statistics PROPN I-LF
+Agency PROPN I-LF
+( PUNCT B-O
+CSA PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+Ethiopia PROPN B-O
+, PUNCT B-O
+in ADP B-O
+the DET B-O
+year NOUN B-O
+2014 NUM B-O
+its PRON B-O
+population NOUN B-O
+was AUX B-O
+about ADP B-O
+3.2 NUM B-O
+million NUM B-O
+[ PUNCT B-O
+17 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+Major ADJ B-O
+Adverse PROPN B-O
+Cardiovascular PROPN B-O
+Events PROPN B-O
+calculator NOUN B-O
+( PUNCT B-O
+CRCRTR-MACE PROPN B-AC
+) PUNCT B-O
+estimates VERB B-O
+the DET B-O
+burden NOUN B-O
+of ADP B-O
+cardiovascular ADJ B-O
+risk NOUN B-O
+in ADP B-O
+renal ADJ B-LF
+transplant NOUN I-LF
+recipients NOUN I-LF
+( PUNCT B-O
+RTR PROPN B-AC
+) PUNCT B-O
+. NOUN B-O
+Our PRON B-O
+recent ADJ B-O
+study NOUN B-O
+of ADP B-O
+95 NUM B-O
+RTR PROPN B-AC
+reported VERB B-O
+the DET B-O
+7 NUM B-O
+- PUNCT B-O
+year NOUN B-O
+median ADJ B-O
+risk NOUN B-O
+of ADP B-O
+cardiovascular ADJ B-O
+events NOUN B-O
+( PUNCT B-O
+CVE PROPN B-O
+) PUNCT B-O
+to ADP B-O
+be AUX B-O
+9.97 NUM B-O
+% NOUN B-O
+, PUNCT B-O
+ranging VERB B-O
+from ADP B-O
+1.93 NUM B-O
+to ADP B-O
+84.27 NUM B-O
+% NOUN B-O
+. NOUN B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+DHQ PROPN B-AC
+, PUNCT B-O
+Diet PROPN B-LF
+History PROPN I-LF
+Questionnaire PROPN I-LF
+. PUNCT B-O
+
+The DET B-O
+main ADJ B-O
+outcome NOUN B-O
+variable NOUN B-O
+was AUX B-O
+the DET B-O
+nutritional ADJ B-O
+status NOUN B-O
+of ADP B-O
+reproductive ADJ B-O
+age NOUN B-O
+women NOUN B-O
+, PUNCT B-O
+measured VERB B-O
+using VERB B-O
+the DET B-O
+WHO PROPN B-AC
+adult NOUN B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+classification NOUN B-O
+[ PUNCT B-O
+13 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+used VERB B-O
+by ADP B-O
+the DET B-O
+Tanzanian PROPN B-O
+National PROPN B-O
+Bureau PROPN B-O
+of ADP B-O
+Statistics PROPN B-O
+and CCONJ B-O
+ICF PROPN B-AC
+International PROPN B-O
+[ PUNCT B-O
+24 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Using VERB B-O
+rat ADJ B-O
+insulinoma NOUN B-O
+INS-1 NOUN B-O
+832/3 NUM B-O
+cells NOUN B-O
+engineered VERB B-O
+by ADP B-O
+clustered VERB B-LF
+regularly ADV I-LF
+interspaced VERB I-LF
+short ADJ I-LF
+palindromic ADJ I-LF
+repeat NOUN I-LF
+( PUNCT B-O
+- PUNCT I-LF
+CRISPR)/CRISPR PROPN B-AC
+associated VERB I-LF
+9 NUM I-LF
+( PUNCT B-O
+Cas9 PROPN B-AC
+) PUNCT B-O
+to PART B-O
+delete VERB B-O
+endogenous ADJ B-O
+GLP-1R PROPN B-AC
+[ X B-O
+40 X B-O
+] X B-O
+stably ADV B-O
+expressing VERB B-O
+human ADJ B-O
+SNAP PROPN B-O
+- PUNCT B-O
+GLP-1R PROPN B-AC
+( PUNCT B-O
+INS-1 NOUN B-O
+832/3 NUM B-O
+GLP-1R−/− PROPN B-AC
+SNAP PROPN B-O
+- PUNCT B-O
+GLP-1R PROPN B-AC
+cells NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+detected VERB B-O
+a DET B-O
+rapid ADJ B-O
+increase NOUN B-O
+in ADP B-O
+TR PROPN B-AC
+-FRET PROPN B-AC
+with ADP B-O
+exendin-4 NOUN B-O
+, PUNCT B-O
+which PRON B-O
+reached VERB B-O
+a DET B-O
+maximum NOUN B-O
+within ADP B-O
+10 NUM B-O
+min NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+1D NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+IRR PROPN B-AC
+, PUNCT B-O
+incidence NOUN B-LF
+rate NOUN I-LF
+ratio NOUN I-LF
+To PART B-O
+cytologically ADV B-O
+characterize VERB B-O
+the DET B-O
+genetic ADJ B-O
+constitution NOUN B-O
+of ADP B-O
+5113 NUM B-O
+, PUNCT B-O
+root NOUN B-O
+cells NOUN B-O
+and CCONJ B-O
+pollen NOUN B-LF
+mother NOUN I-LF
+cells NOUN I-LF
+( PUNCT B-O
+PMCs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+used VERB B-O
+( PUNCT B-O
+Fig NUM B-O
+1 NUM B-O
+and CCONJ B-O
+Table PROPN B-O
+1 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Two NUM B-O
+tissue NOUN B-O
+- PUNCT B-O
+specific ADJ B-O
+DNase NOUN B-LF
+l NOUN I-LF
+hypersensitive ADJ I-LF
+sites NOUN I-LF
+( PUNCT B-O
+DHS PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+this DET B-O
+part NOUN B-O
+of ADP B-O
+the DET B-O
+locus NOUN B-O
+correspond VERB B-O
+to ADP B-O
+a DET B-O
+promoter NOUN B-O
+associated VERB B-O
+with ADP B-O
+DQ52 PROPN B-O
+and CCONJ B-O
+the DET B-O
+intronic ADJ B-O
+enhancer NOUN B-O
+Eμ PROPN B-O
+. PUNCT B-O
+
+A DET B-O
+cluster NOUN B-O
+of ADP B-O
+three NUM B-O
+DHSs PROPN B-AC
+was AUX B-O
+recently ADV B-O
+identified VERB B-O
+just ADV B-O
+5′ NUM B-O
+of ADP B-O
+DFL16.1 NUM B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+to PART B-O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+( PUNCT B-O
+DM PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+established VERB B-O
+as ADP B-O
+one NUM B-O
+of ADP B-O
+the DET B-O
+most ADV B-O
+significant ADJ B-O
+risk NOUN B-O
+factors NOUN B-O
+of ADP B-O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+CAD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+prediabetic ADJ B-O
+conditions NOUN B-O
+such ADJ B-O
+as ADP B-O
+impaired ADJ B-LF
+glucose NOUN I-LF
+tolerance NOUN I-LF
+( PUNCT B-O
+IGT PROPN B-AC
+) PUNCT B-O
+have AUX B-O
+been AUX B-O
+also ADV B-O
+reported VERB B-O
+to PART B-O
+increase VERB B-O
+the DET B-O
+risk NOUN B-O
+of ADP B-O
+cardiovascular ADJ B-O
+events NOUN B-O
+and CCONJ B-O
+affect VERB B-O
+mortality NOUN B-O
+rates NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+, PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+GLM PROPN B-O
+, PUNCT B-O
+generalized ADJ B-O
+linear ADJ B-O
+model NOUN B-O
+; PUNCT B-O
+HCV PROPN B-AC
+, PUNCT B-O
+hepatitis NOUN B-LF
+C PROPN I-LF
+virus NOUN I-LF
+; PUNCT B-O
+HR PROPN B-AC
+, PUNCT B-O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+ITT PROPN B-AC
+, PUNCT B-O
+intention NOUN B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+treat VERB I-LF
+; PUNCT B-O
+OR PROPN B-AC
+, PUNCT B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+PP NOUN B-O
+, PUNCT B-O
+per ADP B-O
+protocol NOUN B-O
+; PUNCT B-O
+SAE NOUN B-O
+, PUNCT B-O
+severe ADJ B-O
+adverse ADJ B-O
+event NOUN B-O
+; PUNCT B-O
+SVR PROPN B-AC
+, PUNCT B-O
+sustained ADJ B-LF
+virologic ADJ I-LF
+response NOUN I-LF
+. PUNCT B-O
+
+AC PROPN B-AC
+, PUNCT B-O
+adenylate NOUN B-LF
+cyclase NOUN I-LF
+catalytic ADJ I-LF
+domain NOUN I-LF
+; PUNCT B-O
+CaM PROPN B-AC
+, PUNCT B-O
+calmodulin NOUN B-LF
+. PUNCT B-O
+
+ASE PROPN B-AC
+, PUNCT B-O
+allele NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+expression NOUN I-LF
+; PUNCT B-O
+BDNF PROPN B-AC
+, PUNCT B-O
+brain NOUN B-LF
+- PUNCT I-LF
+derived VERB I-LF
+neurotrophic ADJ I-LF
+factor NOUN I-LF
+; PUNCT B-O
+F1 PROPN B-AC
+, PUNCT B-O
+first ADJ B-LF
+- PUNCT I-LF
+generation NOUN I-LF
+; PUNCT B-O
+OF PROPN B-AC
+, PUNCT B-O
+owl NOUN B-LF
+finch NOUN I-LF
+; PUNCT B-O
+OZ PROPN B-AC
+, PUNCT B-O
+F1 PROPN B-AC
+hybrid ADJ B-O
+offspring NOUN B-O
+between ADP B-O
+OF PROPN B-AC
+♀ PUNCT B-O
+and CCONJ B-O
+ZF PROPN B-AC
+♂ PUNCT B-O
+; PUNCT B-O
+RA PROPN B-AC
+, PUNCT B-O
+robust ADJ B-LF
+nucleus NOUN I-LF
+of ADP I-LF
+the DET I-LF
+arcopallium NOUN I-LF
+; PUNCT B-O
+RPKM PROPN B-AC
+, PUNCT B-O
+reads NOUN B-LF
+per ADP I-LF
+kilobase NOUN I-LF
+of ADP I-LF
+transcript NOUN I-LF
+per ADP I-LF
+million NUM I-LF
+reads NOUN I-LF
+mapped VERB I-LF
+; PUNCT B-O
+ZF PROPN B-AC
+, PUNCT B-O
+zebra NOUN B-LF
+finch NOUN I-LF
+; PUNCT B-O
+ZO PROPN B-AC
+, PUNCT B-O
+F1 PROPN B-AC
+hybrid ADJ B-O
+offspring NOUN B-O
+between ADP B-O
+ZF PROPN B-AC
+♀ PUNCT B-O
+and CCONJ B-O
+OF PROPN B-AC
+♂ PUNCT B-O
+. PUNCT B-O
+
+Recently ADV B-O
+, PUNCT B-O
+data NOUN B-O
+from ADP B-O
+the DET B-O
+British PROPN B-O
+Cardiac PROPN B-O
+Intervention PROPN B-O
+Society PROPN B-O
+( PUNCT B-O
+BCIS PROPN B-O
+) PUNCT B-O
+PCI PROPN B-AC
+database NOUN B-O
+[ X B-O
+9 NUM B-O
+] X B-O
+and CCONJ B-O
+Korea PROPN B-O
+Acute PROPN B-O
+Myocardial PROPN B-O
+Infarction PROPN B-O
+Registry PROPN B-O
+[ X B-O
+10 NUM B-O
+, PUNCT B-O
+11 NUM B-O
+] X B-O
+showed VERB B-O
+significantly ADV B-O
+lower ADJ B-O
+cumulative ADJ B-O
+mortality NOUN B-O
+rates NOUN B-O
+in ADP B-O
+patients NOUN B-O
+who PRON B-O
+underwent VERB B-O
+multivessel NOUN B-O
+( PUNCT B-O
+MV)-PCI NOUN B-O
+than ADP B-O
+in ADP B-O
+those PRON B-O
+who PRON B-O
+underwent VERB B-O
+infarct NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+artery NOUN I-LF
+( PUNCT B-O
+IRA)-only PROPN B-AC
+PCI PROPN B-AC
+, PUNCT B-O
+demonstrating VERB B-O
+that SCONJ B-O
+LVSD PROPN B-O
+is AUX B-O
+a DET B-O
+strong ADJ B-O
+predictor NOUN B-O
+of ADP B-O
+all DET B-O
+- PUNCT B-O
+cause NOUN B-O
+mortality NOUN B-O
+. PUNCT B-O
+
+Phosphoglycerate NOUN B-LF
+kinase NOUN I-LF
+( PUNCT B-O
+PGK1 PROPN B-AC
+) PUNCT B-O
+catalyzes VERB B-O
+the DET B-O
+reversible ADJ B-O
+phosphotransfer NOUN B-O
+reaction NOUN B-O
+from ADP B-O
+1 NUM B-LF
+, PUNCT I-LF
+3 NUM I-LF
+- PUNCT I-LF
+bisphosphoglycerate NOUN I-LF
+( PUNCT B-O
+1,3-BPG PROPN B-AC
+) PUNCT B-O
+to PART B-O
+ADP PROPN B-O
+to PART B-O
+form VERB B-O
+3 NUM B-LF
+- PUNCT I-LF
+phosphoglycerate NOUN I-LF
+( PUNCT B-O
+3 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+ATP NOUN B-O
+. PUNCT B-O
+
+By ADP B-O
+controlling VERB B-O
+ATP NOUN B-O
+and CCONJ B-O
+-PG3 PROPN B-AC
+levels NOUN B-O
+, PUNCT B-O
+-PGPGK1 PROPN B-AC
+plays VERB B-O
+an DET B-O
+important ADJ B-O
+role NOUN B-O
+in ADP B-O
+coordinating VERB B-O
+energy NOUN B-O
+production NOUN B-O
+with ADP B-O
+biosynthesis NOUN B-O
+and CCONJ B-O
+redox NOUN B-O
+balance NOUN B-O
+. PUNCT B-O
+
+CeMM PROPN B-AC
+, PUNCT B-O
+C. PROPN B-O
+elegans PROPN B-O
+maintenance NOUN B-O
+medium NOUN B-O
+; PUNCT B-O
+hlh-30 PROPN B-AC
+, PUNCT B-O
+basic ADJ B-LF
+helix NOUN I-LF
+– PUNCT I-LF
+loop NOUN I-LF
+– PUNCT I-LF
+helix NOUN I-LF
+transcription NOUN I-LF
+factor NOUN I-LF
+30 NUM I-LF
+; PUNCT B-O
+hlh-30(lf PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+loss NOUN B-O
+- PUNCT B-O
+of ADP B-O
+- PUNCT B-O
+function NOUN B-O
+tm1978 PROPN B-AC
+mutation NOUN B-O
+hlh-30 PROPN B-AC
+; PUNCT B-O
+nhr-31 NOUN B-O
+, PUNCT B-O
+nuclear ADJ B-O
+hormone NOUN B-O
+receptor NOUN B-O
+31 NUM B-O
+; PUNCT B-O
+nhr-31(oe NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+overexpressed VERB B-O
+nhr-31 NOUN B-O
+; PUNCT B-O
+SEM PROPN B-AC
+, PUNCT B-O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+. PUNCT B-O
+
+Nucleotide NOUN B-LF
+- NOUN I-LF
+binding VERB I-LF
+leucine NOUN I-LF
+- NOUN I-LF
+rich ADJ I-LF
+repeat NOUN I-LF
+receptors NOUN I-LF
+( PUNCT B-O
+NLRs PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+key ADJ B-O
+players NOUN B-O
+in ADP B-O
+this DET B-O
+process NOUN B-O
+and CCONJ B-O
+perceive VERB B-O
+the DET B-O
+occurrence NOUN B-O
+of ADP B-O
+nonself NOUN B-O
+- NOUN B-O
+activities NOUN B-O
+or CCONJ B-O
+foreign ADJ B-O
+molecules NOUN B-O
+. PUNCT B-O
+
+All DET B-O
+imaging NOUN B-O
+experiments NOUN B-O
+with ADP B-O
+the DET B-O
+exception NOUN B-O
+of ADP B-O
+those PRON B-O
+depicted VERB B-O
+in ADP B-O
+Fig NOUN B-O
+1B–1E NUM B-O
+and CCONJ B-O
+Fig NOUN B-O
+B NOUN B-O
+in ADP B-O
+S1 NOUN B-O
+Fig NOUN B-O
+were AUX B-O
+performed VERB B-O
+at ADP B-O
+30 NUM B-O
+° NOUN B-O
+C NOUN B-O
+on ADP B-O
+a DET B-O
+Nikon PROPN B-O
+Eclipse PROPN B-O
+Ti PROPN B-O
+inverted ADJ B-O
+microscope NOUN B-O
+equipped VERB B-O
+with ADP B-O
+a DET B-O
+motorized VERB B-O
+laser NOUN B-O
+total ADJ B-LF
+internal ADJ I-LF
+reflection NOUN I-LF
+fluorescence NOUN I-LF
+( PUNCT B-O
+TIRF PROPN B-AC
+) PUNCT B-O
+illumination NOUN B-O
+unit NOUN B-O
+, PUNCT B-O
+a DET B-O
+Borealis PROPN B-O
+beam NOUN B-O
+conditioning NOUN B-O
+unit NOUN B-O
+( PUNCT B-O
+Andor PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+CSU PROPN B-O
+- PUNCT B-O
+W1 PROPN B-O
+Yokugawa PROPN B-O
+spinning VERB B-O
+disk NOUN B-O
+( PUNCT B-O
+Andor PROPN B-O
+; PUNCT B-O
+Belfast PROPN B-O
+, PUNCT B-O
+Northern PROPN B-O
+Ireland PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+60X PROPN B-O
+PlanApo PROPN B-O
+TIRF PROPN B-AC
+1.49 NUM B-O
+numerical ADJ B-LF
+aperture NOUN I-LF
+( PUNCT B-O
+NA PROPN B-AC
+) PUNCT B-O
+objective NOUN B-O
+( PUNCT B-O
+Nikon PROPN B-O
+; PUNCT B-O
+Toyko PROPN B-O
+, PUNCT B-O
+Japan PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+an DET B-O
+iXon PROPN B-O
+Ultra PROPN B-O
+EMCCD PROPN B-O
+camera NOUN B-O
+( PUNCT B-O
+Andor PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+a DET B-O
+laser NOUN B-O
+merge NOUN B-O
+module NOUN B-O
+( PUNCT B-O
+LMM5 PROPN B-O
+, PUNCT B-O
+Spectral PROPN B-O
+Applied PROPN B-O
+Research PROPN B-O
+; PUNCT B-O
+Exton PROPN B-O
+, PUNCT B-O
+PA PROPN B-O
+) PUNCT B-O
+equipped VERB B-O
+with ADP B-O
+405 NUM B-O
+, PUNCT B-O
+440 NUM B-O
+, PUNCT B-O
+488 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+561 NUM B-O
+- PUNCT B-O
+nm NOUN B-O
+laser NOUN B-O
+lines NOUN B-O
+. PUNCT B-O
+
+Four NUM B-O
+irrigation NOUN B-O
+systems NOUN B-O
+were AUX B-O
+examined VERB B-O
+in ADP B-O
+this DET B-O
+study NOUN B-O
+: PUNCT B-O
+furrow NOUN B-LF
+irrigation NOUN I-LF
+( PUNCT B-O
+FI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+micro NOUN B-LF
+- NOUN I-LF
+sprinkler NOUN I-LF
+irrigation NOUN I-LF
+( PUNCT B-O
+MS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+plastic NOUN B-O
+film NOUN B-O
+mulching NOUN B-O
+( PUNCT B-O
+PF PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+plastic NOUN B-O
+film NOUN B-O
+mulching NOUN B-O
+combined VERB B-O
+with ADP B-O
+micro NOUN B-LF
+- NOUN I-LF
+sprinkler NOUN I-LF
+irrigation NOUN I-LF
+( PUNCT B-O
+PF+MS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Of ADP B-O
+these PRON B-O
+, PUNCT B-O
+FI PROPN B-AC
+is AUX B-O
+the DET B-O
+local ADJ B-O
+irrigation NOUN B-O
+method NOUN B-O
+widely ADV B-O
+used VERB B-O
+by ADP B-O
+the DET B-O
+local ADJ B-O
+farmers NOUN B-O
+and CCONJ B-O
+thus ADV B-O
+we PRON B-O
+treated VERB B-O
+FI PROPN B-AC
+as ADP B-O
+the DET B-O
+control NOUN B-O
+. PUNCT B-O
+
+ADC PROPN B-AC
+, PUNCT B-O
+Apparent ADJ B-LF
+Diffusion NOUN I-LF
+Coefficient PROPN I-LF
+; PUNCT B-O
+IPca PROPN B-AC
+, PUNCT B-O
+insignificant ADJ B-LF
+prostate NOUN I-LF
+cancer NOUN I-LF
+; PUNCT B-O
+CSPca PROPN B-AC
+, PUNCT B-O
+clinically ADV B-LF
+significant ADJ I-LF
+prostate NOUN I-LF
+cancer NOUN I-LF
+. PUNCT B-O
+
+We PRON B-O
+investigated VERB B-O
+557 NUM B-O
+women NOUN B-O
+, PUNCT B-O
+recruited VERB B-O
+between ADP B-O
+2009 NUM B-O
+and CCONJ B-O
+2014 NUM B-O
+from ADP B-O
+the DET B-O
+UK PROPN B-LF
+Pregnancies PROPN I-LF
+Better PROPN I-LF
+Eating PROPN I-LF
+and CCONJ I-LF
+Activity PROPN I-LF
+Trial PROPN I-LF
+( PUNCT B-O
+UPBEAT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+randomised ADJ B-LF
+controlled VERB I-LF
+trial NOUN I-LF
+( PUNCT B-O
+RCT PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+of ADP B-O
+a DET B-O
+lifestyle NOUN B-O
+intervention NOUN B-O
+( PUNCT B-O
+low ADJ B-O
+glycaemic ADJ B-LF
+index NOUN I-LF
+( PUNCT B-O
+GI PROPN B-AC
+) PUNCT B-O
+diet NOUN B-O
+plus CCONJ B-O
+physical ADJ B-O
+activity NOUN B-O
+) PUNCT B-O
+in ADP B-O
+pregnant ADJ B-O
+women NOUN B-O
+with ADP B-O
+obesity NOUN B-O
+( PUNCT B-O
+294 NUM B-O
+contol NOUN B-O
+, PUNCT B-O
+263 NUM B-O
+intervention NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Epidemiological ADJ B-O
+studies NOUN B-O
+that PRON B-O
+were AUX B-O
+to PART B-O
+be AUX B-O
+included VERB B-O
+in ADP B-O
+the DET B-O
+current ADJ B-O
+meta NOUN B-O
+- PUNCT B-O
+analysis NOUN B-O
+studies NOUN B-O
+should AUX B-O
+meet VERB B-O
+the DET B-O
+following ADJ B-O
+criteria NOUN B-O
+: PUNCT B-O
+1 X B-O
+) PUNCT B-O
+was AUX B-O
+a DET B-O
+population- NOUN B-O
+or CCONJ B-O
+hospital NOUN B-O
+- PUNCT B-O
+based VERB B-O
+, PUNCT B-O
+case NOUN B-O
+- PUNCT B-O
+control NOUN B-O
+study NOUN B-O
+or CCONJ B-O
+a DET B-O
+prospective ADJ B-O
+or CCONJ B-O
+retrospective ADJ B-O
+cohort NOUN B-O
+study NOUN B-O
+; PUNCT B-O
+2 X B-O
+) PUNCT B-O
+provided VERB B-O
+the DET B-O
+coffee NOUN B-O
+intake NOUN B-O
+level NOUN B-O
+category NOUN B-O
+and CCONJ B-O
+the DET B-O
+corresponding ADJ B-O
+relative ADJ B-LF
+risk NOUN I-LF
+( PUNCT B-O
+RR PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+the DET B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT B-O
+OR PROPN B-AC
+) PUNCT B-O
+estimates NOUN B-O
+and CCONJ B-O
+their PRON B-O
+confidential ADJ B-O
+intervals NOUN B-O
+( PUNCT B-O
+95%CIs PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+MM PROPN B-AC
+; PUNCT B-O
+3 X B-O
+) PUNCT B-O
+not PART B-O
+overlapped VERB B-O
+participants NOUN B-O
+with ADP B-O
+other ADJ B-O
+included VERB B-O
+studies NOUN B-O
+. PUNCT B-O
+
+Univariate ADJ B-O
+and CCONJ B-O
+multivariate ADJ B-O
+Cox PROPN B-O
+proportion NOUN B-O
+hazard NOUN B-O
+regression NOUN B-O
+models NOUN B-O
+were AUX B-O
+used VERB B-O
+to PART B-O
+examine VERB B-O
+the DET B-O
+effect NOUN B-O
+of ADP B-O
+HCV PROPN B-AC
+infection NOUN B-O
+on ADP B-O
+cataract NOUN B-O
+risk NOUN B-O
+through ADP B-O
+hazard NOUN B-LF
+ratios NOUN I-LF
+( PUNCT B-O
+HRs PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+their PRON B-O
+respective ADJ B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT B-O
+CIs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+HI PROPN B-AC
+, PUNCT B-O
+haemagglutination NOUN B-LF
+inhibition NOUN I-LF
+; PUNCT B-O
+MCMC PROPN B-AC
+, PUNCT B-O
+Markov PROPN B-LF
+chain NOUN I-LF
+Monte PROPN I-LF
+Carlo PROPN I-LF
+. PUNCT B-O
+
+Cav3 PROPN B-AC
+, PUNCT B-O
+Caveolin-3 PROPN B-LF
+; PUNCT B-O
+CM PROPN B-AC
+, PUNCT B-O
+cardiomyocyte NOUN B-LF
+; PUNCT B-O
+Ct PROPN B-AC
+, PUNCT B-O
+cycle NOUN B-LF
+threshold NOUN I-LF
+value NOUN I-LF
+; PUNCT B-O
+HSA PROPN B-AC
+, PUNCT B-O
+heat NOUN B-LF
+stable ADJ I-LF
+antigen NOUN I-LF
+; PUNCT B-O
+P PROPN B-AC
+, PUNCT B-O
+postnatal ADJ B-LF
+day NOUN I-LF
+; PUNCT B-O
+qRT PROPN B-AC
+, PUNCT B-O
+quantitative ADJ B-LF
+real ADJ I-LF
+time NOUN I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+fluorescence NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+cell NOUN I-LF
+sorting NOUN I-LF
+( PUNCT B-O
+FACS PROPN B-AC
+) PUNCT B-O
+analysis NOUN B-O
+of ADP B-O
+cell NOUN B-O
+cycle NOUN B-O
+showed VERB B-O
+that SCONJ B-O
+ATX-3 PROPN B-AC
+deletion NOUN B-O
+resulted VERB B-O
+in ADP B-O
+an DET B-O
+increased VERB B-O
+proportion NOUN B-O
+of ADP B-O
+cells NOUN B-O
+in ADP B-O
+G2 NOUN B-O
+/ SYM B-O
+M NOUN B-O
+phase NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+4F NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Without ADP B-O
+p53 NOUN B-O
+and CCONJ B-O
+ATX-3 PROPN B-AC
+double ADJ B-O
+KO PROPN B-AC
+MEF PROPN B-AC
+cells NOUN B-O
+in ADP B-O
+hand NOUN B-O
+, PUNCT B-O
+we PRON B-O
+examined VERB B-O
+the DET B-O
+p53 NOUN B-O
+- PUNCT B-O
+dependence NOUN B-O
+of ADP B-O
+this DET B-O
+effect NOUN B-O
+by ADP B-O
+using VERB B-O
+ATX-3 PROPN B-AC
+stably ADV B-O
+knocked VERB B-O
+down ADP B-O
+HCT116 NOUN B-O
+p53+/+ NOUN B-O
+and CCONJ B-O
+HCT116 NOUN B-O
+p53-/- NOUN B-O
+cells NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+Latin PROPN B-LF
+America PROPN I-LF
+( PUNCT B-O
+LA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+proportion NOUN B-O
+of ADP B-O
+BC PROPN B-AC
+in ADP B-O
+women NOUN B-O
+younger ADJ B-O
+than ADP B-O
+45 NUM B-O
+years NOUN B-O
+is AUX B-O
+nearly ADV B-O
+twice DET B-O
+the DET B-O
+proportion NOUN B-O
+in ADP B-O
+developed VERB B-O
+countries NOUN B-O
+, PUNCT B-O
+a DET B-O
+difference NOUN B-O
+that PRON B-O
+is AUX B-O
+only ADV B-O
+partly ADV B-O
+explained VERB B-O
+by ADP B-O
+population NOUN B-O
+age NOUN B-O
+structure NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+mHAI PROPN B-AC
+, PUNCT B-O
+modified ADJ B-LF
+hepatic ADJ I-LF
+activity NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+T2 NOUN B-O
+, PUNCT B-O
+T2 NOUN B-O
+- PUNCT B-O
+weighted VERB B-O
+image NOUN B-O
+; PUNCT B-O
+CE PROPN B-AC
+, PUNCT B-O
+contrast NOUN B-O
+- PUNCT B-O
+enhancement NOUN B-O
+; PUNCT B-O
+RLE PROPN B-AC
+, PUNCT B-O
+relative ADJ B-LF
+liver NOUN I-LF
+enhancement NOUN I-LF
+, PUNCT B-O
+OR PROPN B-AC
+, PUNCT B-O
+Odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+β PUNCT B-O
+, PUNCT B-O
+regression NOUN B-O
+coefficient NOUN B-O
+; PUNCT B-O
+pvp NOUN B-O
+, PUNCT B-O
+portal NOUN B-O
+venous ADJ B-O
+phase NOUN B-O
+; PUNCT B-O
+dp NOUN B-O
+, PUNCT B-O
+delayed VERB B-O
+- PUNCT B-O
+phase NOUN B-O
+. PUNCT B-O
+
+Although SCONJ B-O
+patients NOUN B-O
+supported VERB B-O
+with ADP B-O
+a DET B-O
+Continuous PROPN B-O
+- PUNCT B-O
+Flow PROPN B-O
+Left PROPN B-LF
+Ventricular PROPN I-LF
+Assist PROPN I-LF
+Device PROPN I-LF
+( PUNCT B-O
+CF-LVAD PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+hemodynamically ADV B-O
+stable ADJ B-O
+, PUNCT B-O
+their PRON B-O
+exercise NOUN B-O
+capacity NOUN B-O
+is AUX B-O
+limited ADJ B-O
+. PUNCT B-O
+
+MAD PROPN B-AC
+: PUNCT B-O
+median ADJ B-LF
+absolute ADJ I-LF
+deviation NOUN I-LF
+, PUNCT B-O
+NOTFront PROPN B-AC
+: PUNCT B-O
+percentage NOUN B-O
+of ADP B-O
+misclassified VERB B-O
+DMUs PROPN B-AC
+, PUNCT B-O
+PU20 NUM B-O
+% NOUN B-O
+: PUNCT B-O
+percentage NOUN B-O
+of ADP B-O
+underestimation NOUN B-O
+, PUNCT B-O
+PO20 NUM B-O
+% NOUN B-O
+: PUNCT B-O
+percentage NOUN B-O
+of ADP B-O
+overestimation NOUN B-O
+, PUNCT B-O
+rs NOUN B-O
+: PUNCT B-O
+Spearman PROPN B-O
+’s PART B-O
+rank NOUN B-O
+correlation NOUN B-O
+. PUNCT B-O
+
+CLANS PROPN B-AC
+, PUNCT B-O
+cluster NOUN B-LF
+analysis NOUN I-LF
+of ADP I-LF
+sequences NOUN I-LF
+; PUNCT B-O
+MPP PROPN B-AC
+, PUNCT B-O
+mitochondrial ADJ B-O
+processing NOUN B-O
+peptide NOUN B-O
+; PUNCT B-O
+PreP PROPN B-AC
+, PUNCT B-O
+presequence NOUN B-LF
+protease NOUN I-LF
+; PUNCT B-O
+SPP PROPN B-AC
+, PUNCT B-O
+stromal NOUN B-LF
+processing NOUN I-LF
+peptidase NOUN I-LF
+. PUNCT B-O
+
+Washed VERB B-O
+rod NOUN B-O
+outer ADJ B-O
+segment NOUN B-O
+membranes NOUN B-O
+prepared VERB B-O
+from ADP B-O
+fresh ADJ B-O
+bovine ADJ B-O
+retinas NOUN B-O
+[ X B-O
+36 X B-O
+] PUNCT B-O
+and CCONJ B-O
+cell NOUN B-O
+membranes NOUN B-O
+of ADP B-O
+TE671 PROPN B-O
+cells NOUN B-O
+infected VERB B-O
+with ADP B-O
+either CCONJ B-O
+EF1α NOUN B-O
+- PUNCT B-O
+GC1 PROPN B-AC
+- PUNCT B-O
+IRES PROPN B-AC
+- PUNCT B-O
+eGFP NOUN B-O
+or CCONJ B-O
+EF1α NOUN B-O
+- PUNCT B-O
+eGFP NOUN B-O
+virus NOUN B-O
+were AUX B-O
+reconstituted VERB B-O
+with ADP B-O
+recombinant ADJ B-O
+guanylate NOUN B-LF
+cyclase NOUN I-LF
+activating VERB I-LF
+protein–1 NOUN I-LF
+( PUNCT B-O
+GCAP1 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+assayed VERB B-O
+for ADP B-O
+GC1 PROPN B-AC
+activity NOUN B-O
+as SCONJ B-O
+previously ADV B-O
+described VERB B-O
+[ X B-O
+37 X B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+Multiple PROPN B-LF
+Sclerosis PROPN I-LF
+Impact PROPN I-LF
+Scale–29 PROPN I-LF
+( PUNCT B-O
+MSIS-29 PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+PRO PROPN B-AC
+that PRON B-O
+attempts VERB B-O
+to PART B-O
+assess VERB B-O
+both CCONJ B-O
+physical ADJ B-O
+and CCONJ B-O
+psychological ADJ B-O
+quality NOUN B-O
+of ADP B-O
+life NOUN B-O
+in ADP B-O
+multiple ADJ B-LF
+sclerosis NOUN I-LF
+( PUNCT B-O
+MS PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+By ADP B-O
+comparing VERB B-O
+the DET B-O
+gene NOUN B-O
+expression NOUN B-O
+ratio NOUN B-O
+between ADP B-O
+the DET B-O
+two NUM B-O
+species NOUN B-O
+and CCONJ B-O
+the DET B-O
+allele NOUN B-LF
+- ADJ I-LF
+specific ADJ I-LF
+expression NOUN I-LF
+( PUNCT B-O
+ASE PROPN B-AC
+) PUNCT B-O
+ratio NOUN B-O
+in ADP B-O
+the DET B-O
+F1 PROPN B-AC
+hybrids NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1D NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+we PRON B-O
+assessed VERB B-O
+the DET B-O
+total ADJ B-O
+number NOUN B-O
+of ADP B-O
+genes NOUN B-O
+whose DET B-O
+expression NOUN B-O
+differs VERB B-O
+by ADP B-O
+divergence NOUN B-O
+in ADP B-O
+cis- ADJ B-O
+versus ADP B-O
+trans ADJ B-O
+- ADJ B-O
+transcriptional ADJ B-O
+regulation NOUN B-O
+between ADP B-O
+the DET B-O
+two NUM B-O
+species NOUN B-O
+. PUNCT B-O
+
+Ins PROPN B-O
+= PUNCT B-O
+inositol NOUN B-O
+peak NOUN B-O
+, PUNCT B-O
+Cho PROPN B-AC
+= PUNCT B-O
+choline NOUN B-LF
+peak NOUN B-O
+, PUNCT B-O
+Cr PROPN B-AC
+= PUNCT B-O
+creatine NOUN B-LF
+/ SYM I-LF
+phosphocreatine NOUN I-LF
+peak NOUN B-O
+, PUNCT B-O
+Glx PROPN B-AC
+= PUNCT B-O
+glutamate NOUN B-O
+/ SYM B-O
+glutamine NOUN B-O
+peaks NOUN B-O
+, PUNCT B-O
+NAA PROPN B-AC
+= PUNCT B-O
+N NOUN B-O
+- PUNCT B-O
+acetyl NOUN B-O
+- PUNCT B-O
+aspartate NOUN B-O
+peak NOUN B-O
+. PUNCT B-O
+
+In ADP B-O
+model NOUN B-O
+A NOUN B-O
+, PUNCT B-O
+participants NOUN B-O
+< ADP B-O
+30 NUM B-O
+years NOUN B-O
+old ADJ B-O
+were AUX B-O
+more ADV B-O
+likely ADJ B-O
+to PART B-O
+have VERB B-O
+good ADJ B-O
+SRH PROPN B-AC
+( PUNCT B-O
+Odds NOUN B-LF
+Ratio NOUN I-LF
+( PUNCT B-O
+OR PROPN B-AC
+) PUNCT B-O
+= SYM B-O
+2.022 NUM B-O
+) PUNCT B-O
+than ADP B-O
+participants NOUN B-O
+> ADP B-O
+50 NUM B-O
+. PUNCT B-O
+
+AbSensitivity PROPN B-O
+( PUNCT B-O
+Antibiotic ADJ B-O
+sensitivity NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+Ca PROPN B-AC
+- PUNCT B-O
+Solub PROPN B-O
+( PUNCT B-O
+Calcium NOUN B-LF
+solubilization NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+Zn PROPN B-AC
+- PUNCT B-O
+Solub PROPN B-O
+( PUNCT B-O
+Zinc NOUN B-LF
+solubilization NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+K PROPN B-AC
+- PUNCT B-O
+Solub PROPN B-O
+( PUNCT B-O
+potassium NOUN B-LF
+solubilization NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+Mg PROPN B-AC
+- PUNCT B-O
+Solub PROPN B-O
+( PUNCT B-O
+magnesium NOUN B-LF
+solubilization NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+P PROPN B-AC
+- PUNCT B-O
+Solub PROPN B-O
+( PUNCT B-O
+phosphorus NOUN B-LF
+solubilization NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+During ADP B-O
+the DET B-O
+consultation NOUN B-O
+, PUNCT B-O
+clinical ADJ B-O
+signs NOUN B-O
+of ADP B-O
+a DET B-O
+relevant ADJ B-O
+focused ADJ B-O
+examination NOUN B-O
+were AUX B-O
+also ADV B-O
+recorded VERB B-O
+( PUNCT B-O
+vital ADJ B-O
+and CCONJ B-O
+danger NOUN B-O
+signs NOUN B-O
+, PUNCT B-O
+temperature NOUN B-O
+, PUNCT B-O
+respiratory ADJ B-O
+rate NOUN B-O
+, PUNCT B-O
+malnutrition NOUN B-O
+assessment NOUN B-O
+, PUNCT B-O
+etc X B-O
+. PUNCT B-O
+
+) PUNCT B-O
+along ADP B-O
+with ADP B-O
+laboratory NOUN B-O
+tests NOUN B-O
+recommended VERB B-O
+by ADP B-O
+the DET B-O
+app NOUN B-O
+( PUNCT B-O
+mRDT PROPN B-AC
+, PUNCT B-O
+C NOUN B-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+[ PUNCT B-O
+CRP PROPN B-AC
+] PUNCT B-O
+, PUNCT B-O
+hemoglobin NOUN B-O
+, PUNCT B-O
+urinary ADJ B-O
+dipstick NOUN B-O
+, PUNCT B-O
+etc X B-O
+. PUNCT B-O
+
+) PUNCT B-O
+. PUNCT B-O
+
+Pre NOUN B-LF
+- PUNCT I-LF
+eclampsia NOUN I-LF
+( PUNCT B-O
+PE PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+common ADJ B-O
+pregnancy NOUN B-O
+- PUNCT B-O
+related VERB B-O
+complication NOUN B-O
+affecting VERB B-O
+3 NUM B-O
+% NOUN B-O
+of ADP B-O
+all DET B-O
+pregnancies NOUN B-O
+. PUNCT B-O
+
+Other ADJ B-O
+liver NOUN B-O
+reserve NOUN B-O
+markers NOUN B-O
+, PUNCT B-O
+fibrosis NOUN B-LF
+index NOUN I-LF
+based VERB I-LF
+on ADP I-LF
+4 NUM I-LF
+factors NOUN I-LF
+( PUNCT B-O
+FIB-4 PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+platelet NOUN I-LF
+ratio NOUN I-LF
+( PUNCT B-O
+APRI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+have AUX B-O
+also ADV B-O
+been AUX B-O
+proposed VERB B-O
+to PART B-O
+assess VERB B-O
+liver NOUN B-O
+dysfunction NOUN B-O
+[ PUNCT B-O
+16 NUM B-O
+, PUNCT B-O
+17 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+District NOUN B-O
+and CCONJ B-O
+health NOUN B-O
+centre NOUN B-O
+heads NOUN B-O
+, PUNCT B-O
+neglected VERB B-O
+tropical ADJ B-O
+diseases NOUN B-O
+( PUNCT B-O
+NTD NOUN B-O
+) PUNCT B-O
+focal ADJ B-O
+persons NOUN B-O
+and CCONJ B-O
+integrated VERB B-LF
+eye NOUN I-LF
+care NOUN I-LF
+workers NOUN I-LF
+( PUNCT B-O
+IECWs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+involved VERB B-O
+in ADP B-O
+the DET B-O
+key ADJ B-O
+informant NOUN B-O
+in ADP B-O
+- PUNCT B-O
+depth NOUN B-O
+interview NOUN B-O
+. PUNCT B-O
+
+ART PROPN B-AC
+, PUNCT B-O
+artemisinin PROPN B-LF
+; PUNCT B-O
+IC50 PROPN B-AC
+, PUNCT B-O
+concentration NOUN B-O
+of ADP B-O
+half ADJ B-O
+- PUNCT B-O
+maximal ADJ B-O
+inhibition NOUN B-O
+. PUNCT B-O
+
+n NOUN B-O
+= VERB B-O
+number NOUN B-O
+of ADP B-O
+cases NOUN B-O
+; PUNCT B-O
+OR PROPN B-AC
+= VERB B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+CI PROPN B-AC
+= VERB B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT B-O
+IQR PROPN B-AC
+= VERB B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+; PUNCT B-O
+HIV PROPN B-AC
+= VERB B-O
+human ADJ B-LF
+immunodeficiency NOUN I-LF
+virus NOUN I-LF
+; PUNCT B-O
+TB PROPN B-AC
+= VERB B-O
+tuberculosis NOUN B-LF
+; PUNCT B-O
+pre PROPN B-AC
+= VERB B-O
+resistance NOUN B-O
+to ADP B-O
+one NUM B-O
+or CCONJ B-O
+more ADJ B-O
+second ADJ B-O
+- PUNCT B-O
+line NOUN B-O
+injectable ADJ B-O
+drugs NOUN B-O
+; PUNCT B-O
+-XDRSLID-TBpre PROPN B-AC
+= VERB B-O
+resistance NOUN B-O
+to ADP B-O
+one NUM B-O
+or CCONJ B-O
+more ADJ B-O
+fluoroquinolones NOUN B-O
+. PUNCT B-O
+
+SMC PROPN B-AC
+, PUNCT B-O
+seasonal ADJ B-LF
+malaria NOUN I-LF
+chemoprevention NOUN I-LF
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+present ADJ B-O
+experimental ADJ B-O
+setting NOUN B-O
+, PUNCT B-O
+adult ADJ B-O
+male ADJ B-O
+C57BL PROPN B-O
+/ SYM B-O
+N6 NUM B-O
+mice NOUN B-O
+were AUX B-O
+either CCONJ B-O
+flown VERB B-O
+aboard ADV B-O
+the DET B-O
+BION PROPN B-O
+- PUNCT B-O
+M1 PROPN B-O
+biosatellite NOUN B-O
+for ADP B-O
+30 NUM B-O
+days NOUN B-O
+on ADP B-O
+orbit NOUN B-O
+( PUNCT B-O
+BION PROPN B-O
+- PUNCT B-O
+flown VERB B-O
+= PUNCT B-O
+BF PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+housed VERB B-O
+as SCONJ B-O
+sex- NOUN B-O
+and CCONJ B-O
+age NOUN B-O
+- PUNCT B-O
+matched VERB B-O
+cohorts NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= PUNCT B-O
+5 NUM B-O
+each PRON B-O
+) PUNCT B-O
+in ADP B-O
+a DET B-O
+replicate ADJ B-O
+flight NOUN B-O
+habitat NOUN B-O
+on ADP B-O
+Earth PROPN B-O
+( PUNCT B-O
+BION PROPN B-O
+- PUNCT B-O
+ground NOUN B-O
+= PUNCT B-O
+BG PROPN B-AC
+) PUNCT B-O
+as SCONJ B-O
+reference NOUN B-O
+flight NOUN B-LF
+control NOUN I-LF
+, PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+standard ADJ B-O
+animal NOUN B-O
+cages NOUN B-O
+concomitant ADJ B-O
+to ADP B-O
+the DET B-O
+duration NOUN B-O
+of ADP B-O
+the DET B-O
+biosatellite NOUN B-O
+flight NOUN B-O
+( PUNCT B-O
+flight NOUN B-LF
+control NOUN I-LF
+= PUNCT B-O
+FC PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Mice NOUN B-O
+flown VERB B-O
+aboard ADV B-O
+of ADP B-O
+the DET B-O
+biosatellite NOUN B-O
+were AUX B-O
+in ADP B-O
+good ADJ B-O
+condition NOUN B-O
+after ADP B-O
+landing NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+previously ADV B-O
+reported VERB B-O
+by ADP B-O
+Andreev PROPN B-O
+- PUNCT B-O
+Andrievskiy PROPN B-O
+[ PUNCT B-O
+17 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+this DET B-O
+study NOUN B-O
+, PUNCT B-O
+we PRON B-O
+sought VERB B-O
+to PART B-O
+test VERB B-O
+whether SCONJ B-O
+elevated ADJ B-O
+levels NOUN B-O
+of ADP B-O
+Arc PROPN B-O
+interfere VERB B-O
+with ADP B-O
+brain NOUN B-LF
+- PUNCT I-LF
+derived VERB I-LF
+neurotrophic ADJ I-LF
+factor NOUN I-LF
+( PUNCT B-O
+BDNF PROPN B-AC
+) PUNCT B-O
+TrkB PROPN B-O
+receptor NOUN B-O
+signaling NOUN B-O
+, PUNCT B-O
+which PRON B-O
+is AUX B-O
+known VERB B-O
+to PART B-O
+be AUX B-O
+essential ADJ B-O
+for ADP B-O
+both CCONJ B-O
+the DET B-O
+induction NOUN B-O
+and CCONJ B-O
+maintenance NOUN B-O
+of ADP B-O
+LTP PROPN B-AC
+. PUNCT B-O
+
+We PRON B-O
+report VERB B-O
+that SCONJ B-O
+TrkB PROPN B-O
+signaling NOUN B-O
+in ADP B-O
+the DET B-O
+AS PROPN B-AC
+mouse NOUN B-O
+is AUX B-O
+defective ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+show VERB B-O
+that SCONJ B-O
+reduction NOUN B-O
+of ADP B-O
+Arc PROPN B-O
+expression NOUN B-O
+to PART B-O
+control VERB B-O
+levels NOUN B-O
+rescues VERB B-O
+the DET B-O
+signaling NOUN B-O
+deficits NOUN B-O
+. PUNCT B-O
+
+One NUM B-O
+key NOUN B-O
+molecule NOUN B-O
+in ADP B-O
+this DET B-O
+process NOUN B-O
+is AUX B-O
+an DET B-O
+enzyme NOUN B-O
+named VERB B-O
+D NOUN B-LF
+- NOUN I-LF
+aminoacyl NOUN I-LF
+- NOUN I-LF
+tRNA NOUN I-LF
+deacylase NOUN I-LF
+( PUNCT B-O
+DTD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+hydrolyses VERB B-O
+D NOUN B-O
+- NOUN B-O
+amino NOUN B-O
+acids NOUN B-O
+attached VERB B-O
+to ADP B-O
+tRNA NOUN B-O
+molecules NOUN B-O
+( PUNCT B-O
+a DET B-O
+D NOUN B-O
+- NOUN B-O
+aminoacyl NOUN B-O
+- NOUN B-O
+tRNA NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+we PRON B-O
+show VERB B-O
+that SCONJ B-O
+besides SCONJ B-O
+acting VERB B-O
+on ADP B-O
+D NOUN B-O
+- NOUN B-O
+aminoacyl NOUN B-O
+- NOUN B-O
+tRNA NOUN B-O
+, PUNCT B-O
+DTD PROPN B-AC
+also ADV B-O
+efficiently ADV B-O
+hydrolyses VERB B-O
+the DET B-O
+achiral ADJ B-O
+glycine NOUN B-O
+attached VERB B-O
+to ADP B-O
+tRNA NOUN B-O
+— PUNCT B-O
+glycyl NOUN B-O
+- NOUN B-O
+tRNA(Gly)—as NOUN B-O
+DTD PROPN B-AC
+’s PART B-O
+active ADJ B-O
+site NOUN B-O
+pocket NOUN B-O
+can AUX B-O
+not PART B-O
+discriminate VERB B-O
+between ADP B-O
+D NOUN B-O
+- NOUN B-O
+amino NOUN B-O
+acids NOUN B-O
+and CCONJ B-O
+glycine NOUN B-O
+. PUNCT B-O
+
+SVR PROPN B-AC
+response NOUN B-O
+rates NOUN B-O
+were AUX B-O
+calculated VERB B-O
+using VERB B-O
+relative ADJ B-LF
+risk NOUN I-LF
+( PUNCT B-O
+RR PROPN B-AC
+) PUNCT B-O
+differences NOUN B-O
+using VERB B-O
+chi NOUN B-O
+- PUNCT B-O
+square ADJ B-O
+test NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+São PROPN B-LF
+Paulo PROPN I-LF
+Autopsy PROPN I-LF
+Service PROPN I-LF
+( PUNCT B-O
+SPAS PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+the DET B-O
+only ADJ B-O
+morgue NOUN B-O
+serving VERB B-O
+the DET B-O
+metropolitan ADJ B-O
+area NOUN B-O
+of ADP B-O
+São PROPN B-O
+Paulo PROPN B-O
+( PUNCT B-O
+Brazil PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Consistent ADJ B-O
+with ADP B-O
+our PRON B-O
+hypothesis NOUN B-O
+, PUNCT B-O
+we PRON B-O
+found VERB B-O
+that SCONJ B-O
+a DET B-O
+strong ADJ B-O
+phospho NOUN B-O
+- PUNCT B-O
+Rb PROPN B-AC
+S249 PROPN B-O
+staining NOUN B-O
+positively ADV B-O
+correlated VERB B-O
+with ADP B-O
+tumor NOUN B-O
+grade NOUN B-O
+exclusively ADV B-O
+in ADP B-O
+squamous ADJ B-LF
+cell NOUN I-LF
+carcinomas NOUN I-LF
+( PUNCT B-O
+SCC PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+not PART B-O
+in ADP B-O
+adenocarcinomas NOUN B-LF
+( PUNCT B-O
+AC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+meaning VERB B-O
+that SCONJ B-O
+most ADJ B-O
+of ADP B-O
+the DET B-O
+SCC PROPN B-AC
+tumors NOUN B-O
+with ADP B-O
+higher ADJ B-O
+grades NOUN B-O
+also ADV B-O
+had VERB B-O
+high ADJ B-O
+scores NOUN B-O
+for ADP B-O
+phospho NOUN B-O
+- PUNCT B-O
+Rb PROPN B-AC
+S249 PROPN B-O
+positive ADJ B-O
+cells NOUN B-O
+. PUNCT B-O
+
+An DET B-O
+observation NOUN B-O
+that PRON B-O
+seems VERB B-O
+to PART B-O
+be AUX B-O
+at ADP B-O
+odds NOUN B-O
+with ADP B-O
+the DET B-O
+findings NOUN B-O
+from ADP B-O
+these DET B-O
+ex X B-O
+vivo X B-O
+studies NOUN B-O
+is AUX B-O
+that PRON B-O
+the DET B-O
+eyeblink NOUN B-O
+conditioned VERB B-LF
+response NOUN I-LF
+( PUNCT B-O
+CR PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+well ADV B-O
+- PUNCT B-O
+predicted VERB B-O
+by ADP B-O
+a DET B-O
+suppression NOUN B-O
+in ADP B-O
+Purkinje PROPN B-O
+cell NOUN B-O
+simple ADJ B-O
+spike NOUN B-O
+firing NOUN B-O
+that PRON B-O
+may AUX B-O
+last VERB B-O
+for ADP B-O
+several ADJ B-O
+hundreds NOUN B-O
+of ADP B-O
+milliseconds NOUN B-O
+[ X B-O
+28–31 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+While SCONJ B-O
+PQ PROPN B-AC
+is AUX B-O
+tolerated VERB B-O
+in ADP B-O
+most ADJ B-O
+patients NOUN B-O
+, PUNCT B-O
+it PRON B-O
+can AUX B-O
+cause VERB B-O
+haemolysis NOUN B-O
+in ADP B-O
+patients NOUN B-O
+with ADP B-O
+glucose-6 NOUN B-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+deficiency NOUN I-LF
+( PUNCT B-O
+G6PDd PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+severity NOUN B-O
+of ADP B-O
+which PRON B-O
+is AUX B-O
+dependent ADJ B-O
+on ADP B-O
+the DET B-O
+underlying VERB B-O
+genetic ADJ B-O
+variant NOUN B-O
+, PUNCT B-O
+the DET B-O
+dose NOUN B-O
+of ADP B-O
+PQ PROPN B-AC
+administered VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+age NOUN B-O
+of ADP B-O
+the DET B-O
+patient NOUN B-O
+’s PART B-O
+red ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+( PUNCT B-O
+RBC PROPN B-AC
+) PUNCT B-O
+population NOUN B-O
+[ X B-O
+7,8 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+BAC PROPN B-AC
+, PUNCT B-O
+bacterial ADJ B-LF
+artificial ADJ I-LF
+chromosome NOUN I-LF
+; PUNCT B-O
+CENP PROPN B-AC
+, PUNCT B-O
+centromere NOUN B-LF
+protein NOUN I-LF
+A NOUN I-LF
+; PUNCT B-O
+-ACenX PROPN B-AC
+, PUNCT B-O
+X NOUN B-LF
+centromere NOUN I-LF
+; PUNCT B-O
+ChIP PROPN B-AC
+, PUNCT B-O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+sequencing NOUN B-O
+; PUNCT B-O
+-seqCRM PROPN B-AC
+, PUNCT B-O
+centromeric ADJ B-LF
+retrotransposons NOUN I-LF
+of ADP I-LF
+maize NOUN I-LF
+; PUNCT B-O
+CRR PROPN B-AC
+, PUNCT B-O
+centromeric ADJ B-LF
+retrotransposons NOUN I-LF
+of ADP I-LF
+rice NOUN I-LF
+; PUNCT B-O
+CRW PROPN B-AC
+, PUNCT B-O
+centromeric ADJ B-LF
+retrotransposons NOUN I-LF
+of ADP I-LF
+wheat NOUN I-LF
+; PUNCT B-O
+FISH PROPN B-AC
+, PUNCT B-O
+fluorescence NOUN B-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+; PUNCT B-O
+LAVA PROPN B-AC
+, PUNCT B-O
+LINE PROPN B-LF
+- PUNCT I-LF
+LINE PROPN B-AC
+Alu PROPN I-LF
+- PUNCT I-LF
+VNTR PROPN I-LF
+- PUNCT I-LF
+Alu PROPN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+; PUNCT B-O
+LINE PROPN B-AC
+, PUNCT B-O
+long ADJ B-LF
+interspersed VERB I-LF
+nuclear ADJ I-LF
+element NOUN I-LF
+; PUNCT B-O
+LTR PROPN B-AC
+, PUNCT B-O
+long ADJ B-LF
+terminal ADJ I-LF
+repeat NOUN I-LF
+; PUNCT B-O
+Mya PROPN B-O
+, PUNCT B-O
+million NUM B-O
+years NOUN B-O
+ago ADV B-O
+. PUNCT B-O
+
+Recently ADV B-O
+, PUNCT B-O
+we PRON B-O
+developed VERB B-O
+a DET B-O
+novel ADJ B-O
+and CCONJ B-O
+sensitive ADJ B-O
+XOR PROPN B-AC
+assay NOUN B-O
+for ADP B-O
+the DET B-O
+measurement NOUN B-O
+of ADP B-O
+human ADJ B-O
+plasma NOUN B-O
+XOR PROPN B-AC
+activity NOUN B-O
+that PRON B-O
+is AUX B-O
+based VERB B-O
+on ADP B-O
+[ X B-O
+13C2,15N2]xanthine NOUN B-O
+coupled VERB B-O
+with ADP B-O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+( PUNCT B-O
+mass NOUN I-LF
+LC)/triplequadrupole PROPN B-AC
+spectrometry NOUN I-LF
+( PUNCT B-O
+TQMS PROPN B-AC
+) PUNCT B-O
+[ X B-O
+18,19 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Cadherins NOUN B-O
+form VERB B-O
+an DET B-O
+adhesive ADJ B-O
+interface NOUN B-O
+all ADV B-O
+along ADP B-O
+the DET B-O
+lateral ADJ B-O
+domain NOUN B-O
+but CCONJ B-O
+are AUX B-O
+also ADV B-O
+organised VERB B-O
+into ADP B-O
+special ADJ B-O
+complexes NOUN B-O
+known VERB B-O
+as ADP B-O
+zonula NOUN B-LF
+adherens NOUN I-LF
+( PUNCT B-O
+ZA PROPN B-AC
+) PUNCT B-O
+that PRON B-O
+are AUX B-O
+localised VERB B-O
+at ADP B-O
+the DET B-O
+apical ADJ B-O
+end NOUN B-O
+. PUNCT B-O
+
+At ADP B-O
+baseline NOUN B-O
+, PUNCT B-O
+mothers NOUN B-O
+had VERB B-O
+weight NOUN B-O
+, PUNCT B-O
+mid ADJ B-LF
+- ADJ I-LF
+upper ADJ I-LF
+arm NOUN I-LF
+circumference NOUN I-LF
+( PUNCT B-O
+MUAC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+hemoglobin NOUN B-O
+( PUNCT B-O
+Hemocue PROPN B-O
+, PUNCT B-O
+Ängelholm PROPN B-O
+, PUNCT B-O
+Sweden PROPN B-O
+) PUNCT B-O
+measured VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+were AUX B-O
+tested VERB B-O
+for ADP B-O
+HIV PROPN B-O
+using VERB B-O
+a DET B-O
+rapid ADJ B-O
+test NOUN B-O
+algorithm NOUN B-O
+. PUNCT B-O
+
+Disease PROPN B-O
+activity NOUN B-O
+reflected VERB B-O
+the DET B-O
+direct ADJ B-O
+results NOUN B-O
+of ADP B-O
+treatment NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+measured VERB B-O
+with ADP B-O
+the DET B-O
+Disease PROPN B-LF
+Activity PROPN I-LF
+Score–28 NUM I-LF
+with ADP I-LF
+erythrocyte NOUN I-LF
+sedimentation NOUN I-LF
+rate NOUN I-LF
+( PUNCT B-O
+DAS28-ESR PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+33 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+AUC PROPN B-AC
+, PUNCT B-O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+; PUNCT B-O
+CITL PROPN B-O
+, PUNCT B-O
+calibration NOUN B-O
+in ADP B-O
+the DET B-O
+large ADJ B-O
+; PUNCT B-O
+E NOUN B-O
+:O NOUN B-O
+, PUNCT B-O
+ratio NOUN B-O
+of ADP B-O
+expected VERB B-O
+( PUNCT B-O
+predicted VERB B-O
+) PUNCT B-O
+probability NOUN B-O
+vs ADP B-O
+observed ADJ B-O
+frequency NOUN B-O
+of ADP B-O
+the DET B-O
+outcome NOUN B-O
+; PUNCT B-O
+STm PROPN B-AC
+, PUNCT B-O
+symptoms NOUN B-LF
+and CCONJ I-LF
+tests NOUN I-LF
+model NOUN I-LF
+; PUNCT B-O
+Tm PROPN B-AC
+, PUNCT B-O
+tests NOUN B-LF
+- PUNCT I-LF
+only ADV I-LF
+model NOUN I-LF
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+GPi PROPN B-AC
+, PUNCT B-O
+globus NOUN B-LF
+pallidus X I-LF
+- PUNCT I-LF
+internus X I-LF
+; PUNCT B-O
+max NOUN B-O
+, PUNCT B-O
+maximum NOUN B-O
+; PUNCT B-O
+min NOUN B-O
+, PUNCT B-O
+minimum NOUN B-O
+; PUNCT B-O
+Mvt PROPN B-O
+, PUNCT B-O
+movement NOUN B-O
+; PUNCT B-O
+NHP PROPN B-AC
+, PUNCT B-O
+nonhuman ADJ B-LF
+primate NOUN I-LF
+; PUNCT B-O
+sp NOUN B-O
+, PUNCT B-O
+spikes NOUN B-O
+; PUNCT B-O
+VLa PROPN B-AC
+, PUNCT B-O
+ventrolateral ADJ B-LF
+anterior ADJ I-LF
+nucleus NOUN I-LF
+Recently ADV B-O
+, PUNCT B-O
+it PRON B-O
+was AUX B-O
+reported VERB B-O
+that SCONJ B-O
+5 NUM B-LF
+- PUNCT I-LF
+HT2 NOUN I-LF
+receptors NOUN I-LF
+( PUNCT B-O
+5-HT2Rs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+expressed VERB B-O
+in ADP B-O
+cartilage NOUN B-O
+tissues NOUN B-O
+lacking VERB B-O
+both CCONJ B-O
+vessels NOUN B-O
+and CCONJ B-O
+neurons NOUN B-O
+, PUNCT B-O
+suggesting VERB B-O
+possible ADJ B-O
+novel ADJ B-O
+functions NOUN B-O
+of ADP B-O
+5-HT PROPN B-AC
+during ADP B-O
+cartilage NOUN B-O
+development NOUN B-O
+and CCONJ B-O
+regeneration NOUN B-O
+. PUNCT B-O
+
+MOI PROPN B-AC
+, PUNCT B-O
+multiplicity NOUN B-LF
+of ADP I-LF
+infection NOUN I-LF
+. PUNCT B-O
+
+Changes NOUN B-O
+in ADP B-O
+anthropometric ADJ B-O
+indices NOUN B-O
+[ PUNCT B-O
+Weight NOUN B-O
+, PUNCT B-O
+Body PROPN B-O
+- PUNCT B-O
+Mass NOUN B-O
+- PUNCT B-O
+Index PROPN B-O
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+waist NOUN B-O
+- PUNCT B-O
+circumference NOUN B-O
+( PUNCT B-O
+WC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+waist NOUN B-O
+- PUNCT B-O
+hip NOUN B-O
+ratio NOUN B-O
+( PUNCT B-O
+WHR PROPN B-AC
+) PUNCT B-O
+] PUNCT B-O
+, PUNCT B-O
+clinical ADJ B-O
+[ PUNCT B-O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+SBP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+diastolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+DBP PROPN B-AC
+) PUNCT B-O
+] PUNCT B-O
+and CCONJ B-O
+biochemical ADJ B-O
+measurements NOUN B-O
+[ PUNCT B-O
+Triglycerides NOUN B-LF
+( PUNCT B-O
+TG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+High ADJ B-LF
+Density NOUN I-LF
+Lipoprotein NOUN I-LF
+( PUNCT B-O
+HDL PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Total PROPN B-LF
+Cholesterol PROPN I-LF
+( PUNCT B-O
+TC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+HbA1c% PROPN B-AC
+] PUNCT B-O
+at ADP B-O
+baseline NOUN B-O
+and CCONJ B-O
+follow NOUN B-O
+- PUNCT B-O
+up ADP B-O
+were AUX B-O
+compared VERB B-O
+. PUNCT B-O
+
+Significance NOUN B-O
+was AUX B-O
+calculated VERB B-O
+by ADP B-O
+a DET B-O
+two NUM B-O
+- PUNCT B-O
+tailed ADJ B-O
+t NOUN B-O
+test NOUN B-O
+. PUNCT B-O
+
+* PUNCT B-O
+p NOUN B-O
+= SYM B-O
+0.03 NUM B-O
+. PUNCT B-O
+
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+HMWCK PROPN B-AC
+( PUNCT B-O
+high ADJ B-LF
+molecular ADJ I-LF
+weight NOUN I-LF
+cytokeratin NOUN I-LF
+) PUNCT B-O
+staining NOUN B-O
+, PUNCT B-O
+whose DET B-O
+expression NOUN B-O
+in ADP B-O
+upper ADJ B-O
+layers NOUN B-O
+marks VERB B-O
+squamous ADJ B-O
+stratifying VERB B-O
+epithelia NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+C NOUN B-O
+) PUNCT B-O
+Staining NOUN B-O
+for ADP B-O
+TMPRSS11B NOUN B-O
+, PUNCT B-O
+a DET B-O
+marker NOUN B-O
+of ADP B-O
+squamous ADJ B-O
+epithelia NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+D NOUN B-O
+, PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+Lenti PROPN B-O
+- PUNCT B-O
+SOX2 PROPN B-O
+induces VERB B-O
+hyperplasia NOUN B-O
+. PUNCT B-O
+
+Taiwan PROPN B-O
+’s PART B-O
+National PROPN B-LF
+Health PROPN I-LF
+Insurance PROPN I-LF
+( PUNCT B-O
+NHI PROPN B-AC
+) PUNCT B-O
+program NOUN B-O
+is AUX B-O
+a DET B-O
+universal ADJ B-O
+insurance NOUN B-O
+program NOUN B-O
+that PRON B-O
+was AUX B-O
+launched VERB B-O
+in ADP B-O
+1995 NUM B-O
+. PUNCT B-O
+
+We PRON B-O
+conducted VERB B-O
+a DET B-O
+meta NOUN B-O
+- ADJ B-O
+analysis NOUN B-O
+and CCONJ B-O
+meta NOUN B-O
+- ADJ B-O
+regression NOUN B-O
+of ADP B-O
+randomized ADJ B-LF
+controlled VERB I-LF
+trials NOUN I-LF
+( PUNCT B-O
+RCTs PROPN B-AC
+) PUNCT B-O
+evaluating VERB B-O
+SGLT2i PROPN B-AC
+in ADP B-O
+T1DM PROPN B-AC
+to PART B-O
+assess VERB B-O
+moderators NOUN B-O
+of ADP B-O
+the DET B-O
+relative ADJ B-LF
+risk NOUN I-LF
+( PUNCT B-O
+RR PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+DKA PROPN B-AC
+, PUNCT B-O
+of ADP B-O
+glycemic ADJ B-O
+( PUNCT B-O
+HbA1c NOUN B-O
+, PUNCT B-O
+fasting VERB B-O
+plasma NOUN B-O
+glucose NOUN B-O
+, PUNCT B-O
+continuous ADJ B-O
+glucose NOUN B-O
+monitoring NOUN B-O
+parameters NOUN B-O
+, PUNCT B-O
+insulin NOUN B-O
+dose NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+insulin NOUN B-O
+sensitivity NOUN B-O
+indices NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+non ADJ B-O
+- ADJ B-O
+glycemic ADJ B-O
+( PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+systolic ADJ B-O
+BP PROPN B-AC
+, PUNCT B-O
+renal ADJ B-O
+function NOUN B-O
+, PUNCT B-O
+albuminuria NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+diabetic ADJ B-O
+eye NOUN B-O
+disorders NOUN B-O
+) PUNCT B-O
+efficacy NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+of ADP B-O
+other ADJ B-O
+safety NOUN B-O
+outcomes NOUN B-O
+( PUNCT B-O
+including VERB B-O
+hypoglycemia NOUN B-O
+, PUNCT B-O
+infections NOUN B-O
+, PUNCT B-O
+major ADJ B-O
+adverse ADJ B-O
+cardiovascular ADJ B-O
+events NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+death NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Diffusion PROPN B-LF
+Tensor PROPN I-LF
+Imaging PROPN I-LF
+( PUNCT B-O
+DTI PROPN B-AC
+) PUNCT B-O
+studies NOUN B-O
+suggest VERB B-O
+that SCONJ B-O
+at ADP B-O
+birth NOUN B-O
+all DET B-O
+major ADJ B-O
+fiber NOUN B-O
+systems NOUN B-O
+are AUX B-O
+in ADP B-O
+place NOUN B-O
+, PUNCT B-O
+despite SCONJ B-O
+low ADJ B-O
+anisotropy NOUN B-O
+value NOUN B-O
+[ PUNCT B-O
+70 NUM B-O
+] PUNCT B-O
+and CCONJ B-O
+incomplete ADJ B-O
+myelination NOUN B-O
+[ PUNCT B-O
+71 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Increasing VERB B-O
+phytoene NOUN B-O
+concentrations NOUN B-O
+favor VERB B-O
+phytofluene NOUN B-LF
+release NOUN B-O
+, PUNCT B-O
+with ADP B-O
+the DET B-O
+z PROPN B-AC
+: NOUN B-O
+pf PROPN B-AC
+ratio NOUN B-O
+decreasing VERB B-O
+from ADP B-O
+ca X B-O
+. PUNCT B-O
+
+4:1 NUM B-O
+to ADP B-O
+1:1 NUM B-O
+( PUNCT B-O
+Fig NOUN B-O
+6B NUM B-O
+, PUNCT B-O
+dotted ADJ B-O
+line NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+underlying ADJ B-O
+numerical ADJ B-O
+data NOUN B-O
+for ADP B-O
+this DET B-O
+figure NOUN B-O
+can AUX B-O
+be AUX B-O
+found VERB B-O
+in ADP B-O
+S1 PROPN B-O
+Data PROPN B-O
+. PUNCT B-O
+
+dpi PROPN B-AC
+, PUNCT B-O
+days NOUN B-LF
+postinoculation NOUN I-LF
+; PUNCT B-O
+N NOUN B-O
+- PUNCT B-O
+acetylneuraminic NOUN B-O
+acid NOUN B-O
+; PUNCT B-O
+siaT PROPN B-AC
+, PUNCT B-O
+predicted VERB B-LF
+sialic ADJ I-LF
+acid NOUN I-LF
+transporter NOUN I-LF
+; PUNCT B-O
+WT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+type NOUN I-LF
+. PUNCT B-O
+
+CFA PROPN B-AC
+, PUNCT B-O
+complete ADJ B-LF
+Freund PROPN I-LF
+’s PART I-LF
+adjuvant NOUN I-LF
+; PUNCT B-O
+DAPI PROPN B-AC
+, PUNCT B-O
+4′,6 NUM B-LF
+- PUNCT I-LF
+diamidino-2 NOUN I-LF
+- PUNCT I-LF
+phenylindole NOUN I-LF
+; PUNCT B-O
+DRG PROPN B-AC
+, PUNCT B-O
+dorsal ADJ B-LF
+root NOUN I-LF
+ganglia NOUN I-LF
+; PUNCT B-O
+EV PROPN B-AC
+, PUNCT B-O
+empty ADJ B-LF
+vector NOUN I-LF
+; PUNCT B-O
+GFAP PROPN B-AC
+, PUNCT B-O
+glial ADJ B-LF
+fibrillary ADJ I-LF
+acidic ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+HSV PROPN B-AC
+, PUNCT B-O
+herpes NOUN B-LF
+simplex NOUN I-LF
+virus NOUN I-LF
+; PUNCT B-O
+Iba1 PROPN B-AC
+, PUNCT B-O
+ionized VERB B-LF
+calcium NOUN I-LF
+binding VERB I-LF
+adaptor NOUN I-LF
+molecule NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+MM PROPN B-AC
+, PUNCT B-O
+mismatch NOUN B-LF
+ODN PROPN I-LF
+-ODNODN PROPN B-AC
+; PUNCT B-O
+NF200 PROPN B-O
+, PUNCT B-O
+neurofilament NOUN B-O
+200 NUM B-O
+; PUNCT B-O
+ODN PROPN B-AC
+, PUNCT B-O
+oligodeoxynucleotide NOUN B-LF
+; PUNCT B-O
+SC PROPN B-AC
+, PUNCT B-O
+spinal ADJ B-LF
+cord NOUN I-LF
+; PUNCT B-O
+SEM PROPN B-AC
+, PUNCT B-O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+CHD PROPN B-AC
+, PUNCT B-O
+coronary ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+; PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT B-O
+OR PROPN B-AC
+, PUNCT B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT B-O
+CI PROPN B-AC
+, PUNCT B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+. PUNCT B-O
+
+Primaquine PROPN B-LF
+( PUNCT B-O
+PQ PROPN B-AC
+) PUNCT B-O
+actively ADV B-O
+clears VERB B-O
+mature ADJ B-O
+Plasmodium PROPN B-O
+falciparum NOUN B-O
+gametocytes NOUN B-O
+but CCONJ B-O
+in ADP B-O
+glucose-6 NOUN B-O
+- PUNCT B-O
+phosphate NOUN B-O
+dehydrogenase NOUN B-O
+deficient ADJ B-O
+( PUNCT B-O
+G6PDd NOUN B-O
+) PUNCT B-O
+individuals NOUN B-O
+can AUX B-O
+cause VERB B-O
+hemolysis NOUN B-O
+. PUNCT B-O
+
+Further ADV B-O
+, PUNCT B-O
+how SCONJ B-O
+much ADJ B-O
+effect NOUN B-O
+variations NOUN B-O
+in ADP B-O
+r PROPN B-AC
+have AUX B-O
+on ADP B-O
+the DET B-O
+dynamics NOUN B-O
+of ADP B-O
+free ADJ B-O
+virus NOUN B-O
+depended VERB B-O
+on ADP B-O
+the DET B-O
+magnitude NOUN B-O
+of ADP B-O
+the DET B-O
+minimum ADJ B-LF
+activation NOUN I-LF
+rate NOUN I-LF
+of ADP I-LF
+latently ADV I-LF
+infected VERB I-LF
+cells NOUN I-LF
+( PUNCT B-O
+amin PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Homologous ADJ B-O
+recombination NOUN B-O
+can AUX B-O
+also ADV B-O
+have VERB B-O
+a DET B-O
+mutagenic ADJ B-O
+outcome NOUN B-O
+by ADP B-O
+promoting VERB B-O
+recombination NOUN B-O
+between ADP B-O
+nonallelic ADJ B-O
+repeated VERB B-O
+sequences NOUN B-O
+, PUNCT B-O
+leading VERB B-O
+to PART B-O
+genomic ADJ B-O
+instability NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+by ADP B-O
+templating VERB B-O
+repair VERB B-O
+from ADP B-O
+a DET B-O
+homolog NOUN B-O
+rather ADV B-O
+than ADP B-O
+a DET B-O
+sister NOUN B-O
+chromatid NOUN B-O
+, PUNCT B-O
+leading VERB B-O
+to PART B-O
+loss NOUN B-LF
+of ADP I-LF
+heterozygosity NOUN I-LF
+( PUNCT B-O
+LOH PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+a DET B-O
+living VERB B-O
+cell NOUN B-O
+, PUNCT B-O
+multiple ADJ B-O
+pathways NOUN B-O
+compete VERB B-O
+to PART B-O
+repair VERB B-O
+the DET B-O
+same ADJ B-O
+kinds NOUN B-O
+of ADP B-O
+damage NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+exact ADJ B-O
+location NOUN B-O
+of ADP B-O
+Swt1 PROPN B-O
+could AUX B-O
+not PART B-O
+be AUX B-O
+determined VERB B-O
+, PUNCT B-O
+however ADV B-O
+, PUNCT B-O
+because SCONJ B-O
+the DET B-O
+abundance NOUN B-O
+of ADP B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT B-O
+GFP)- PROPN B-AC
+or CCONJ B-O
+immuno ADJ B-O
+- PUNCT B-O
+labeled VERB B-O
+Swt1 PROPN B-O
+expressed VERB B-O
+from ADP B-O
+the DET B-O
+endogenous ADJ B-O
+promoter NOUN B-O
+was AUX B-O
+too ADV B-O
+low ADJ B-O
+to PART B-O
+be AUX B-O
+visualized VERB B-O
+( PUNCT B-O
+unpublished ADJ B-O
+data NOUN B-O
+and CCONJ B-O
+[ X B-O
+18 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+While SCONJ B-O
+initiation NOUN B-O
+requires VERB B-O
+a DET B-O
+rapid ADJ B-O
+but CCONJ B-O
+temporary ADJ B-O
+disappearance NOUN B-O
+of ADP B-O
+Nrg1 PROPN B-O
+via ADP B-O
+activation NOUN B-O
+of ADP B-O
+the DET B-O
+cAMP NOUN B-O
+- PUNCT B-O
+dependent ADJ B-O
+protein NOUN B-O
+kinase NOUN B-O
+A NOUN B-O
+pathway NOUN B-O
+, PUNCT B-O
+maintenance NOUN B-O
+requires VERB B-O
+the DET B-O
+recruitment NOUN B-O
+to ADP B-O
+promoters NOUN B-O
+of ADP B-O
+the DET B-O
+Hda1 NOUN B-O
+histone NOUN B-O
+deacetylase NOUN B-O
+under ADP B-O
+conditions NOUN B-O
+of ADP B-O
+reduced VERB B-O
+signaling NOUN B-O
+by ADP B-O
+the DET B-O
+target NOUN B-LF
+of ADP I-LF
+rapamycin NOUN I-LF
+( PUNCT B-O
+TOR PROPN B-AC
+) PUNCT B-O
+kinase NOUN B-O
+, PUNCT B-O
+leading VERB B-O
+to ADP B-O
+chromatin NOUN B-O
+remodeling NOUN B-O
+that PRON B-O
+blocks VERB B-O
+Nrg1 PROPN B-O
+access NOUN B-O
+to ADP B-O
+the DET B-O
+promoters NOUN B-O
+of ADP B-O
+hypha NOUN B-O
+- PUNCT B-O
+specific ADJ B-O
+genes NOUN B-O
+. PUNCT B-O
+
+Recent ADJ B-O
+studies NOUN B-O
+have AUX B-O
+suggested VERB B-O
+that SCONJ B-O
+these DET B-O
+diseases NOUN B-O
+are AUX B-O
+but ADV B-O
+one NUM B-O
+unique ADJ B-O
+set NOUN B-O
+of ADP B-O
+immunoglobulin NOUN B-LF
+- PUNCT I-LF
+E NOUN I-LF
+( PUNCT B-O
+IgE)-mediated PROPN B-AC
+allergic ADJ B-O
+conditions NOUN B-O
+, PUNCT B-O
+linked VERB B-O
+by ADP B-O
+the DET B-O
+common ADJ B-O
+thread NOUN B-O
+of ADP B-O
+“ PUNCT B-O
+atopic PROPN B-O
+march PROPN B-O
+” PUNCT B-O
+[ PUNCT B-O
+9 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Abbr PROPN B-O
+. PUNCT B-O
+
+: PUNCT B-O
+AN PROPN B-AC
+– PUNCT B-O
+antennal ADJ B-LF
+nerve NOUN I-LF
+; PUNCT B-O
+CDM PROPN B-AC
+– PUNCT B-O
+cibarial NOUN B-O
+dilator NOUN B-O
+muscle NOUN B-O
+; PUNCT B-O
+CNS PROPN B-AC
+– PUNCT B-O
+central ADJ B-LF
+nervous ADJ I-LF
+system NOUN I-LF
+. PUNCT B-O
+
+Strains NOUN B-O
+: PUNCT B-O
+DLY12943 PROPN B-O
+, PUNCT B-O
+DLY7593 PROPN B-O
+( PUNCT B-O
+B NOUN B-O
+- NOUN B-O
+D NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+DLY22883 PROPN B-O
+( PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+DLY22928 PROPN B-O
+( PUNCT B-O
+F NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+KS PROPN B-O
+, PUNCT B-O
+Kolmogorov PROPN B-O
+– PUNCT B-O
+Smirnov PROPN B-O
+; PUNCT B-O
+MAT PROPN B-AC
+, PUNCT B-O
+mating NOUN B-LF
+type NOUN I-LF
+; PUNCT B-O
+MFα1 PROPN B-AC
+, PUNCT B-O
+major ADJ B-LF
+α PUNCT I-LF
+- NOUN I-LF
+factor NOUN I-LF
+gene NOUN I-LF
+1 NUM I-LF
+; PUNCT B-O
+sf PROPN B-AC
+, PUNCT B-O
+superfolder NOUN B-LF
+; PUNCT B-O
+TEF1 PROPN B-AC
+, PUNCT B-O
+translation NOUN B-LF
+elongation NOUN I-LF
+factor NOUN I-LF
+1 NUM I-LF
+. PUNCT B-O
+
+The DET B-O
+Hopkins PROPN B-LF
+Symptom PROPN I-LF
+Checklist-37 PROPN I-LF
+for ADP I-LF
+Adolescents PROPN I-LF
+( PUNCT B-O
+HSCL-37A PROPN B-AC
+; PUNCT B-O
+[ PUNCT B-O
+48 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+examines VERB B-O
+both CCONJ B-O
+internalizing VERB B-O
+symptoms NOUN B-O
+such ADJ B-O
+as ADP B-O
+depression NOUN B-O
+and CCONJ B-O
+anxiety NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+externalizing VERB B-O
+symptoms NOUN B-O
+. PUNCT B-O
+
+These DET B-O
+studies NOUN B-O
+also ADV B-O
+demonstrated VERB B-O
+variation NOUN B-O
+in ADP B-O
+transmission NOUN B-O
+potential NOUN B-O
+after ADP B-O
+different ADJ B-O
+ACTs PROPN B-AC
+, PUNCT B-O
+with ADP B-O
+artemether NOUN B-LF
+- PUNCT I-LF
+lumefantrine NOUN I-LF
+( PUNCT B-O
+AL PROPN B-AC
+) PUNCT B-O
+being AUX B-O
+associated VERB B-O
+with ADP B-O
+lower ADJ B-O
+post ADJ B-O
+- PUNCT B-O
+treatment ADJ B-O
+gametocyte ADJ B-O
+carriage NOUN B-O
+and CCONJ B-O
+transmission NOUN B-O
+potential NOUN B-O
+compared VERB B-O
+to ADP B-O
+dihydroartemisinin NOUN B-LF
+- PUNCT I-LF
+piperaquine NOUN I-LF
+( PUNCT B-O
+DP PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+12 NUM B-O
+, PUNCT B-O
+13 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Alternating VERB B-O
+phase NOUN B-O
+radiofrequency NOUN B-LF
+( PUNCT B-O
+RF PROPN B-AC
+) PUNCT B-O
+pulse NOUN B-O
+acquisition NOUN B-O
+technique NOUN B-O
+implying VERB B-O
+the DET B-O
+acquisition NOUN B-O
+of ADP B-O
+multiple ADJ B-O
+images NOUN B-O
+, PUNCT B-O
+has AUX B-O
+been AUX B-O
+combined VERB B-O
+with ADP B-O
+the DET B-O
+maximum ADJ B-O
+- PUNCT B-O
+intensity NOUN B-O
+, PUNCT B-O
+the DET B-O
+complex ADJ B-O
+- PUNCT B-O
+sum NOUN B-O
+, PUNCT B-O
+the DET B-O
+magnitude NOUN B-O
+- PUNCT B-O
+sum NOUN B-O
+combinations NOUN B-O
+to PART B-O
+eliminate VERB B-O
+them PRON B-O
+. PUNCT B-O
+
+Common ADJ B-O
+bacterial ADJ B-O
+pathogens NOUN B-O
+such ADJ B-O
+as ADP B-O
+Salmonella PROPN B-O
+, PUNCT B-O
+Shigella PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+Yersinia PROPN B-O
+spp NOUN B-O
+. PUNCT B-O
+
+invade VERB B-O
+the DET B-O
+gut NOUN B-O
+epithelial ADJ B-O
+barrier NOUN B-O
+, PUNCT B-O
+preferentially ADV B-O
+by ADP B-O
+targeting VERB B-O
+the DET B-O
+relatively ADV B-O
+small ADJ B-O
+number NOUN B-O
+of ADP B-O
+M NOUN B-O
+cells NOUN B-O
+located VERB B-O
+in ADP B-O
+the DET B-O
+follicle NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+epithelium NOUN I-LF
+( PUNCT B-O
+FAE PROPN B-AC
+) PUNCT B-O
+[ X B-O
+1–3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Data NOUN B-O
+were AUX B-O
+collected VERB B-O
+from ADP B-O
+articles NOUN B-O
+published VERB B-O
+in ADP B-O
+2019 NUM B-O
+in ADP B-O
+the DET B-O
+biomedical ADJ B-O
+sciences NOUN B-O
+journals NOUN B-O
+: PUNCT B-O
+British PROPN B-LF
+Journal PROPN I-LF
+of ADP I-LF
+Pharmacology PROPN I-LF
+( PUNCT B-O
+BJP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Journal PROPN B-LF
+of ADP I-LF
+Pharmacy PROPN I-LF
+and CCONJ I-LF
+Pharmacology PROPN I-LF
+( PUNCT B-O
+JPP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Frontiers PROPN B-LF
+in ADP I-LF
+Pharmacology PROPN I-LF
+( PUNCT B-O
+FP PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Journal PROPN B-LF
+of ADP I-LF
+Cell PROPN I-LF
+Biology PROPN I-LF
+( PUNCT B-O
+JCB PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Journal PROPN B-LF
+of ADP I-LF
+Cell PROPN I-LF
+Science PROPN I-LF
+( PUNCT B-O
+JCS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Cells PROPN B-LF
+( PUNCT B-O
+CEL PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+Journal PROPN B-LF
+of ADP I-LF
+Biological PROPN I-LF
+Chemistry PROPN I-LF
+( PUNCT B-O
+JBC PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Proceedings PROPN B-LF
+of ADP I-LF
+the DET I-LF
+National PROPN I-LF
+Academy PROPN I-LF
+of ADP I-LF
+Sciences PROPN I-LF
+( PUNCT B-O
+PNAS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+N NOUN B-O
+= SYM B-O
+200 NUM B-O
+articles NOUN B-O
+analyzed VERB B-O
+in ADP B-O
+each DET B-O
+scientific ADJ B-O
+journal NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+24 NUM B-O
+studies NOUN B-O
+that PRON B-O
+contributed VERB B-O
+data NOUN B-O
+on ADP B-O
+the DET B-O
+diagnosis NOUN B-O
+and CCONJ B-O
+treatment NOUN B-O
+practices NOUN B-O
+of ADP B-O
+healthcare NOUN B-O
+providers NOUN B-O
+were AUX B-O
+undertaken VERB B-O
+in ADP B-O
+ten NUM B-O
+countries NOUN B-O
+, PUNCT B-O
+involving VERB B-O
+a DET B-O
+range NOUN B-O
+of ADP B-O
+cadres NOUN B-O
+, PUNCT B-O
+including VERB B-O
+medical ADJ B-O
+doctors NOUN B-O
+and CCONJ B-O
+nurses NOUN B-O
+, PUNCT B-O
+pharmacists NOUN B-O
+, PUNCT B-O
+drug NOUN B-O
+vendors NOUN B-O
+, PUNCT B-O
+traditional ADJ B-LF
+birth NOUN I-LF
+attendants NOUN I-LF
+( PUNCT B-O
+TBAs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+community NOUN B-LF
+health NOUN I-LF
+workers NOUN I-LF
+( PUNCT B-O
+CHWs PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+Tables NOUN B-O
+2 NUM B-O
+and CCONJ B-O
+3 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+fFN PROPN B-AC
+, PUNCT B-O
+fetal ADJ B-LF
+fibronectin NOUN I-LF
+; PUNCT B-O
+IPD PROPN B-AC
+, PUNCT B-O
+individual ADJ B-LF
+participant NOUN I-LF
+data NOUN I-LF
+; PUNCT B-O
+IQR PROPN B-O
+, PUNCT B-O
+interquartile ADJ B-O
+range NOUN B-O
+; PUNCT B-O
+SD NOUN B-O
+, PUNCT B-O
+standard ADJ B-O
+deviation NOUN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+ITH PROPN B-AC
+, PUNCT B-O
+intra ADJ B-LF
+- ADJ I-LF
+tumour ADJ I-LF
+heterogeneity NOUN I-LF
+; PUNCT B-O
+DNAm PROPN B-AC
+, PUNCT B-O
+DNA NOUN B-LF
+methylation NOUN I-LF
+; PUNCT B-O
+OC PROPN B-AC
+, PUNCT B-O
+ovarian ADJ B-LF
+cancer NOUN I-LF
+; PUNCT B-O
+UCEC PROPN B-AC
+, PUNCT B-O
+uterine ADJ B-LF
+corpus NOUN I-LF
+endometrial ADJ I-LF
+carcinoma NOUN I-LF
+; PUNCT B-O
+BRCA PROPN B-AC
+, PUNCT B-O
+breast NOUN B-LF
+cancer NOUN I-LF
+invasive ADJ I-LF
+carcinoma NOUN I-LF
+. PUNCT B-O
+
+Also ADV B-O
+, PUNCT B-O
+F→ PROPN B-AC
+, PUNCT B-O
+dv1→ NOUN B-O
+, PUNCT B-O
+dΩ PROPN B-AC
+and CCONJ B-O
+σ PROPN B-AC
+are AUX B-O
+external ADJ B-O
+force NOUN B-O
+vector NOUN B-O
+, PUNCT B-O
+molecules NOUN B-O
+of ADP B-O
+class NOUN B-O
+with ADP B-O
+velocity NOUN B-O
+v1 NOUN B-O
+, PUNCT B-O
+elementary ADJ B-LF
+solid ADJ I-LF
+angle NOUN I-LF
+and CCONJ B-O
+collision NOUN B-LF
+cross NOUN I-LF
+section NOUN I-LF
+[ X B-O
+5,6 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+RNA NOUN B-O
+was AUX B-O
+extracted VERB B-O
+from ADP B-O
+liver NOUN B-O
+using VERB B-O
+TRIzol PROPN B-O
+reagent NOUN B-O
+( PUNCT B-O
+Life PROPN B-O
+Technologies PROPN B-O
+, PUNCT B-O
+Carlsbad PROPN B-O
+, PUNCT B-O
+CA PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+purified VERB B-O
+using VERB B-O
+the DET B-O
+RNeasy PROPN B-O
+kit NOUN B-O
+( PUNCT B-O
+Qiagen PROPN B-O
+, PUNCT B-O
+Valencia PROPN B-O
+, PUNCT B-O
+CA PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+RNA NOUN B-O
+integrity NOUN B-O
+was AUX B-O
+verified VERB B-O
+by ADP B-O
+formaldehyde NOUN B-O
+gel NOUN B-O
+electrophoresis NOUN B-O
+. PUNCT B-O
+
+cDNA NOUN B-O
+was AUX B-O
+synthesized VERB B-O
+using VERB B-O
+iScript PROPN B-O
+( PUNCT B-O
+BioRad PROPN B-O
+, PUNCT B-O
+Hercules PROPN B-O
+, PUNCT B-O
+CA PROPN B-O
+) PUNCT B-O
+; PUNCT B-O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+( PUNCT B-O
+qPCR PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+performed VERB B-O
+with ADP B-O
+TaqMan PROPN B-O
+® PROPN B-O
+assay NOUN B-O
+kits NOUN B-O
+( PUNCT B-O
+Life PROPN B-O
+Technologies PROPN B-O
+, PUNCT B-O
+Carlsbad PROPN B-O
+, PUNCT B-O
+CA PROPN B-O
+) PUNCT B-O
+using VERB B-O
+β PUNCT B-O
+- NOUN B-O
+glucuronidase NOUN B-O
+as ADP B-O
+the DET B-O
+internal ADJ B-O
+control NOUN B-O
+gene NOUN B-O
+. PUNCT B-O
+
+Previous ADJ B-O
+studies NOUN B-O
+have AUX B-O
+implicated VERB B-O
+that SCONJ B-O
+prolonged VERB B-O
+activation NOUN B-O
+( PUNCT B-O
+> PUNCT B-O
+10 NUM B-O
+min NOUN B-O
+) PUNCT B-O
+of ADP B-O
+mGluR1/5 NOUN B-O
+by ADP B-O
+DHPG PROPN B-AC
+can AUX B-O
+stimulate VERB B-O
+spinal ADJ B-O
+excitatory ADJ B-O
+interneurons NOUN B-O
+to PART B-O
+produce VERB B-O
+endocannabinoids NOUN B-O
+, PUNCT B-O
+which PRON B-O
+act VERB B-O
+as ADP B-O
+retrograde ADJ B-O
+messengers NOUN B-O
+to PART B-O
+stimulate VERB B-O
+Type-1 NOUN B-LF
+cannabinoid NOUN I-LF
+( PUNCT B-O
+CB1 PROPN B-AC
+) PUNCT B-O
+receptors NOUN B-O
+expressed VERB B-O
+at ADP B-O
+inhibitory ADJ B-O
+nerve NOUN B-O
+terminals NOUN B-O
+[ PUNCT B-O
+18 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Some DET B-O
+TUNEL+ NOUN B-O
+cells NOUN B-O
+are AUX B-O
+also ADV B-O
+detected VERB B-O
+in ADP B-O
+the DET B-O
+mantle NOUN B-O
+zone NOUN B-O
+of ADP B-O
+the DET B-O
+PSB PROPN B-AC
+in ADP B-O
+mutant ADJ B-O
+embryos NOUN B-O
+( PUNCT B-O
+Div PROPN B-O
+) PUNCT B-O
+but CCONJ B-O
+do AUX B-O
+not PART B-O
+correspond VERB B-O
+to ADP B-O
+CR PROPN B-AC
+cells NOUN B-O
+since SCONJ B-O
+no DET B-O
+loss NOUN B-O
+of ADP B-O
+Reln PROPN B-O
+was AUX B-O
+observed VERB B-O
+in ADP B-O
+the DET B-O
+lateral ADJ B-LF
+pallium NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+E NOUN B-O
+– PUNCT B-O
+H NOUN B-O
+) PUNCT B-O
+Immunofluorescence NOUN B-O
+using VERB B-O
+Dbx1 NOUN B-O
+antisera NOUN B-O
+showing VERB B-O
+that SCONJ B-O
+at ADP B-O
+the DET B-O
+septum ADJ B-O
+dorsal ADJ B-O
+Dbx1 NOUN B-O
++ NOUN B-O
+cells NOUN B-O
+are AUX B-O
+deleted VERB B-O
+in ADP B-O
+mutant ADJ B-O
+embryos NOUN B-O
+( PUNCT B-O
+F NOUN B-O
+) PUNCT B-O
+compared VERB B-O
+to ADP B-O
+control NOUN B-O
+animals NOUN B-O
+( PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+whereas SCONJ B-O
+ventral ADJ B-O
+Dbx1 NOUN B-O
++ NOUN B-O
+cells NOUN B-O
+are AUX B-O
+not PART B-O
+( PUNCT B-O
+compare VERB B-O
+G PROPN B-O
+and CCONJ B-O
+H NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+situ ADJ B-O
+hybridization NOUN B-O
+for ADP B-O
+Reln PROPN B-O
+( PUNCT B-O
+I NOUN B-O
+, PUNCT B-O
+K NOUN B-O
+, PUNCT B-O
+quantified VERB B-O
+in ADP B-O
+M PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+p73 NOUN B-O
+( PUNCT B-O
+J PROPN B-O
+, PUNCT B-O
+L PROPN B-AC
+, PUNCT B-O
+quantified VERB B-O
+in ADP B-O
+N PROPN B-O
+) PUNCT B-O
+at ADP B-O
+caudal ADJ B-O
+levels NOUN B-O
+shows VERB B-O
+that SCONJ B-O
+there PRON B-O
+is VERB B-O
+no DET B-O
+significant ADJ B-O
+difference NOUN B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+6 NUM B-O
+) PUNCT B-O
+in ADP B-O
+the DET B-O
+numbers NOUN B-O
+of ADP B-O
+Reln+ NOUN B-O
+and CCONJ B-O
+p73 NOUN B-O
++ NOUN B-O
+cells NOUN B-O
+between ADP B-O
+E11.5 NUM B-O
+control NOUN B-O
+( PUNCT B-O
+I NOUN B-O
+and CCONJ B-O
+J PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+Dbx1DTA;Emx1iresCre PROPN B-O
+embryos NOUN B-O
+( PUNCT B-O
+K NOUN B-O
+and CCONJ B-O
+L PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Quantifications NOUN B-O
+of ADP B-O
+the DET B-O
+numbers NOUN B-O
+of ADP B-O
+Reln+ NOUN B-O
+and CCONJ B-O
+p73 NOUN B-O
++ NOUN B-O
+cells NOUN B-O
+in ADP B-O
+L1 NOUN B-O
+( PUNCT B-O
+O NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+L2 NOUN B-O
+( PUNCT B-O
+P NOUN B-O
+) PUNCT B-O
+DM PROPN B-AC
+regions NOUN B-O
+of ADP B-O
+E12.5 NUM B-O
+control NOUN B-O
+( PUNCT B-O
+white ADJ B-O
+bars NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+Dbx1DTA;Emx1iresCre PROPN B-O
+embryos NOUN B-O
+( PUNCT B-O
+black ADJ B-O
+bars NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+3 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+* PUNCT B-O
+P<0.05 NUM B-O
+. PUNCT B-O
+
+CoSMO PROPN B-AC
+, PUNCT B-O
+Cooperation NOUN B-LF
+that PRON I-LF
+is AUX I-LF
+Synthetic ADJ I-LF
+and CCONJ I-LF
+Mutually ADV I-LF
+Obligatory ADJ I-LF
+. PUNCT B-O
+
+Propensity NOUN B-O
+- PUNCT B-O
+score NOUN B-O
+- PUNCT B-O
+matched VERB B-O
+controls NOUN B-O
+were AUX B-O
+selected VERB B-O
+from ADP B-O
+9,246 NUM B-O
+non ADJ B-O
+- PUNCT B-O
+SAMI PROPN B-AC
+patients NOUN B-O
+( PUNCT B-O
+non ADJ B-O
+- PUNCT B-O
+SA PROPN B-AC
+- PUNCT B-O
+MI PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+association NOUN B-O
+of ADP B-O
+SA PROPN B-AC
+and CCONJ B-O
+outcomes NOUN B-O
+including VERB B-O
+all DET B-O
+- PUNCT B-O
+cause NOUN B-O
+mortality NOUN B-O
+and CCONJ B-O
+major ADJ B-LF
+adverse ADJ I-LF
+cardiac ADJ I-LF
+and CCONJ I-LF
+cerebrovascular ADJ I-LF
+events NOUN I-LF
+( PUNCT B-O
+MACCEs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+analyzed VERB B-O
+by ADP B-O
+a DET B-O
+Cox PROPN B-O
+proportional ADJ B-O
+hazards NOUN B-O
+model NOUN B-O
+. PUNCT B-O
+
+AMBA PROPN B-O
+, PUNCT B-O
+Allen PROPN B-O
+Mouse PROPN B-O
+Brain PROPN B-O
+Atlas PROPN B-O
+; PUNCT B-O
+CE PROPN B-O
+, PUNCT B-O
+cerebellum NOUN B-O
+; PUNCT B-O
+Fndc5 PROPN B-O
+, PUNCT B-O
+fibronectin NOUN B-O
+type NOUN B-O
+III NUM B-O
+domain NOUN B-O
+containing VERB B-O
+5 NUM B-O
+; PUNCT B-O
+HB PROPN B-O
+, PUNCT B-O
+hindbrain NOUN B-O
+; PUNCT B-O
+LAV PROPN B-O
+, PUNCT B-O
+lateral ADJ B-O
+vestibular ADJ B-O
+nucleus NOUN B-O
+; PUNCT B-O
+LC PROPN B-O
+, PUNCT B-O
+locus NOUN B-O
+coeruleus NOUN B-O
+; PUNCT B-O
+MV PROPN B-O
+, PUNCT B-O
+medial ADJ B-O
+vestibular ADJ B-O
+nucleus NOUN B-O
+; PUNCT B-O
+OT PROPN B-O
+, PUNCT B-O
+optic ADJ B-O
+tectum NOUN B-O
+; PUNCT B-O
+P56 PROPN B-O
+, PUNCT B-O
+postnatal ADJ B-O
+day NOUN B-O
+56 NUM B-O
+; PUNCT B-O
+Pp NOUN B-O
+, PUNCT B-O
+prepontine ADJ B-O
+area NOUN B-O
+; PUNCT B-O
+SUV PROPN B-AC
+, PUNCT B-O
+superior ADJ B-LF
+vestibular ADJ I-LF
+nucleus NOUN I-LF
+; PUNCT B-O
+TH NOUN B-O
+, PUNCT B-O
+tyrosine NOUN B-O
+hydroxylase NOUN B-O
+; PUNCT B-O
+ZBB PROPN B-AC
+, PUNCT B-O
+Zebrafish PROPN B-LF
+Brain PROPN I-LF
+Browser PROPN I-LF
+. PUNCT B-O
+
+Descending VERB B-LF
+DAD- PROPN B-AC
+aortic ADJ I-LF
+distensibility NOUN I-LF
+. PUNCT B-O
+
+The DET B-O
+present ADJ B-O
+findings NOUN B-O
+of ADP B-O
+an DET B-O
+association NOUN B-O
+between ADP B-O
+recent ADJ B-O
+cannabis NOUN B-O
+use NOUN B-O
+and CCONJ B-O
+psychotic ADJ B-O
+features NOUN B-O
+are AUX B-O
+consistent ADJ B-O
+with ADP B-O
+reports NOUN B-O
+of ADP B-O
+cannabis NOUN B-O
+creating VERB B-O
+an DET B-O
+acute ADJ B-O
+toxic ADJ B-O
+psychosis NOUN B-O
+and CCONJ B-O
+with ADP B-O
+short ADJ B-O
+- PUNCT B-O
+duration NOUN B-O
+effects NOUN B-O
+in ADP B-O
+laboratory NOUN B-O
+studies NOUN B-O
+of ADP B-O
+high ADJ B-O
+doses NOUN B-O
+of ADP B-O
+intravenous ADJ B-O
+tetrahydrocannabinol NOUN B-LF
+( PUNCT B-O
+THC PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+35%–50 NUM B-O
+% NOUN B-O
+of ADP B-O
+healthy ADJ B-O
+participants NOUN B-O
+[ PUNCT B-O
+17,60,61 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This PRON B-O
+overlaps VERB B-O
+the DET B-O
+values NOUN B-O
+for ADP B-O
+the DET B-O
+mammalian ADJ B-O
+stratum NOUN B-O
+4 NUM B-O
+and CCONJ B-O
+3 NUM B-O
+genes NOUN B-O
+( PUNCT B-O
+mean ADJ B-O
+K NOUN B-O
+s NOUN B-O
+values NOUN B-O
+8 NUM B-O
+% NOUN B-O
+and CCONJ B-O
+30 NUM B-O
+% NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+) PUNCT B-O
+; PUNCT B-O
+these DET B-O
+strata NOUN B-O
+are AUX B-O
+inferred VERB B-O
+to PART B-O
+have AUX B-O
+ceased VERB B-O
+recombining VERB B-O
+between ADP B-O
+the DET B-O
+X NOUN B-O
+and CCONJ B-O
+Y NOUN B-O
+30–50 NUM B-O
+million NUM B-LF
+years NOUN I-LF
+ago ADV I-LF
+( PUNCT B-O
+MYA PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+stratum NOUN B-O
+4 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+80–130 NUM B-O
+MYA PROPN B-AC
+for ADP B-O
+stratum NOUN B-O
+3 NUM B-O
+, PUNCT B-O
+whereas SCONJ B-O
+strata NOUN B-O
+1 NUM B-O
+and CCONJ B-O
+2 NUM B-O
+diverged VERB B-O
+130–320 NUM B-O
+MYA PROPN B-AC
+[ PUNCT B-O
+9,11 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+ChIP PROPN B-AC
+, PUNCT B-O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+and CCONJ I-LF
+sequencing NOUN I-LF
+; PUNCT B-O
+-SeqdnIκBα PROPN B-AC
+, PUNCT B-O
+dominant ADJ B-O
+negative ADJ B-O
+mutated VERB B-O
+IκBα PROPN B-O
+; PUNCT B-O
+FDR PROPN B-AC
+, PUNCT B-O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+; PUNCT B-O
+GEO PROPN B-O
+, PUNCT B-O
+Gene PROPN B-O
+Expression PROPN B-O
+Omnibus PROPN B-O
+; PUNCT B-O
+hnRNP NOUN B-O
+, PUNCT B-O
+heterogeneous ADJ B-O
+nuclear ADJ B-O
+ribonucleoprotein NOUN B-O
+; PUNCT B-O
+IκBα PROPN B-O
+, PUNCT B-O
+NFKB PROPN B-O
+inhibitor NOUN B-O
+alpha NOUN B-O
+; PUNCT B-O
+NC PROPN B-O
+, PUNCT B-O
+nitrocellulose NOUN B-O
+; PUNCT B-O
+NF PROPN B-AC
+, PUNCT B-O
+nuclear ADJ B-LF
+factor NOUN I-LF
+kappa NOUN I-LF
+B NOUN I-LF
+; PUNCT B-O
+-κBP+I PROPN B-AC
+, PUNCT B-O
+phorbol NOUN B-O
+12 NUM B-O
+- PUNCT B-O
+myristate NOUN B-O
+13 NUM B-O
+- PUNCT B-O
+acetate NOUN B-O
+and CCONJ B-O
+ionomycin NOUN B-O
+; PUNCT B-O
+RNA PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT B-O
+-SeqTet PROPN B-AC
+, PUNCT B-O
+tetracycline NOUN B-LF
+. PUNCT B-O
+
+The DET B-O
+concerted ADJ B-O
+action NOUN B-O
+of ADP B-O
+the DET B-O
+three NUM B-O
+HIV-1 PROPN B-O
+proteins NOUN B-O
+Nef PROPN B-O
+, PUNCT B-O
+Env PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+Vpu PROPN B-O
+results VERB B-O
+in ADP B-O
+a DET B-O
+complete ADJ B-O
+removal NOUN B-O
+of ADP B-O
+CD4 NOUN B-O
+from ADP B-O
+the DET B-O
+surface NOUN B-O
+of ADP B-O
+HIV PROPN B-O
+infected VERB B-O
+cells NOUN B-O
+through ADP B-O
+( PUNCT B-O
+i X B-O
+) PUNCT B-O
+enhanced VERB B-O
+routing NOUN B-O
+of ADP B-O
+CD4 NOUN B-O
+to ADP B-O
+the DET B-O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT B-O
+ER PROPN B-AC
+) PUNCT B-O
+degradation NOUN B-O
+pathway NOUN B-O
+[ PUNCT B-O
+12],[13 X B-O
+] PUNCT B-O
+and CCONJ B-O
+( PUNCT B-O
+ii X B-O
+) PUNCT B-O
+activated VERB B-O
+endocytosis NOUN B-O
+and CCONJ B-O
+lysosomal ADJ B-O
+degradation NOUN B-O
+[ PUNCT B-O
+14],[15 X B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Morphologic ADJ B-O
+parameters NOUN B-O
+collected VERB B-O
+by ADP B-O
+USG PROPN B-AC
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+cross ADJ B-LF
+- ADJ I-LF
+sectional ADJ I-LF
+area NOUN I-LF
+( PUNCT B-O
+CSA PROPN B-AC
+) PUNCT B-O
+obtained VERB B-O
+from ADP B-O
+transverse ADJ B-O
+scans NOUN B-O
+, PUNCT B-O
+provide VERB B-O
+useful ADJ B-O
+information NOUN B-O
+complementary ADJ B-O
+to ADP B-O
+electrophysiological ADJ B-O
+data NOUN B-O
+[ PUNCT B-O
+11–13 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+TNAP PROPN B-AC
+dephosphorylates VERB B-O
+poly NOUN B-O
+- PUNCT B-O
+inosine NOUN B-O
+: PUNCT B-O
+cytosine NOUN B-O
+( PUNCT B-O
+Toll PROPN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptor NOUN I-LF
+( PUNCT B-O
+TLR PROPN B-AC
+) PUNCT B-O
+3 NUM B-O
+agonist NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+LPS PROPN B-AC
+from ADP B-O
+Klebsiella PROPN B-O
+pneumoniae NOUN B-O
+and CCONJ B-O
+Salmonella PROPN B-O
+minnesota PROPN B-O
+( PUNCT B-O
+TLR4 PROPN B-O
+agonists NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+HPLC PROPN B-AC
+analysis NOUN B-O
+was AUX B-O
+carried VERB B-O
+out ADP B-O
+using VERB B-O
+an DET B-O
+Agilent PROPN B-O
+1260 NUM B-O
+Infinity PROPN B-O
+system NOUN B-O
+( PUNCT B-O
+Agilent PROPN B-O
+Technologies PROPN B-O
+) PUNCT B-O
+with ADP B-O
+ultraviolet NOUN B-LF
+( PUNCT B-O
+UV PROPN B-AC
+) PUNCT B-O
+detection NOUN B-O
+at ADP B-O
+278 NUM B-O
+nm NOUN B-O
+( PUNCT B-O
+maximum ADJ B-O
+absorbance NOUN B-O
+of ADP B-O
+Cm PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+44 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+GFP PROPN B-AC
+, PUNCT B-O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT B-O
+PS PROPN B-AC
+, PUNCT B-O
+phosphatidylserine NOUN B-LF
+; PUNCT B-O
+UAS PROPN B-AC
+, PUNCT B-O
+upstream ADJ B-LF
+activating VERB I-LF
+sequence NOUN I-LF
+. PUNCT B-O
+
+Among ADP B-O
+urban ADJ B-O
+, PUNCT B-O
+migrant NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+rural ADJ B-O
+men NOUN B-O
+the DET B-O
+age- NOUN B-O
+and CCONJ B-O
+factory NOUN B-O
+- PUNCT B-O
+adjusted VERB B-O
+percentages NOUN B-O
+classified VERB B-O
+as ADP B-O
+obese ADJ B-O
+( PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+[ X B-O
+BMI PROPN B-AC
+] X B-O
+> NUM B-O
+25 NUM B-O
+kg NOUN B-O
+/ SYM B-O
+m2 NOUN B-O
+) PUNCT B-O
+were AUX B-O
+41.9 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X B-O
+CI PROPN B-AC
+] X B-O
+39.1–44.7 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+37.8 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+35.0–40.6 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+19.0 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+17.0–21.0 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+respectively ADV B-O
+, PUNCT B-O
+and CCONJ B-O
+as ADP B-O
+diabetic ADJ B-O
+were AUX B-O
+13.5 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+11.6–15.4 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+14.3 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+12.2–16.4 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+6.2 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+5.0–7.4 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+Viruses NOUN B-O
+cause VERB B-O
+respiratory ADJ B-LF
+tract NOUN I-LF
+infections NOUN I-LF
+( PUNCT B-O
+RTIs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+if SCONJ B-O
+severe ADJ B-O
+, PUNCT B-O
+can AUX B-O
+lead VERB B-O
+to ADP B-O
+a DET B-O
+visit NOUN B-O
+to ADP B-O
+the DET B-O
+Emergency PROPN B-LF
+Department PROPN I-LF
+( PUNCT B-O
+ED PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+hospitalization NOUN B-O
+. PUNCT B-O
+
+MDA PROPN B-AC
+, PUNCT B-O
+mass PROPN B-LF
+drug PROPN I-LF
+administration NOUN I-LF
+; PUNCT B-O
+IRS PROPN B-AC
+, PUNCT B-O
+indoor ADJ B-LF
+residual NOUN I-LF
+spraying NOUN I-LF
+; PUNCT B-O
+rfMDA PROPN B-AC
+, PUNCT B-O
+reactive ADJ B-LF
+focal ADJ I-LF
+mass PROPN B-LF
+drug PROPN I-LF
+administration NOUN I-LF
+; PUNCT B-O
+LLIN PROPN B-AC
+, PUNCT B-O
+long ADJ B-LF
+lasting ADJ I-LF
+insecticidal ADJ I-LF
+nets NOUN I-LF
+; PUNCT B-O
+NMCP PROPN B-AC
+, PUNCT B-O
+national ADJ B-O
+malaria NOUN B-O
+control NOUN B-O
+programme NOUN B-O
+; PUNCT B-O
+Contr PROPN B-O
+, PUNCT B-O
+contribution NOUN B-O
+; PUNCT B-O
+Ref PROPN B-O
+, PUNCT B-O
+reference NOUN B-O
+. PUNCT B-O
+
+Exploring VERB B-O
+potential ADJ B-O
+subgroup NOUN B-O
+effects NOUN B-O
+of ADP B-O
+maternal ADJ B-O
+age NOUN B-O
+, PUNCT B-O
+parity NOUN B-O
+, PUNCT B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+fetal ADJ B-O
+sex NOUN B-O
+is AUX B-O
+therefore ADV B-O
+impossible ADJ B-O
+in ADP B-O
+individual ADJ B-O
+trials NOUN B-O
+. PUNCT B-O
+
+This DET B-O
+process NOUN B-O
+can AUX B-O
+be AUX B-O
+accomplished VERB B-O
+by ADP B-O
+alternative ADJ B-O
+precursor NOUN B-LF
+messenger NOUN I-LF
+RNA NOUN I-LF
+( PUNCT B-O
+pre-mRNA PROPN B-AC
+) PUNCT B-O
+splicing NOUN B-O
+. PUNCT B-O
+
+CIN PROPN B-AC
+, PUNCT B-O
+cervical ADJ B-LF
+intraepithelial ADJ I-LF
+neoplasia NOUN I-LF
+. PUNCT B-O
+
+De X B-O
+novo X B-O
+pathogenic ADJ B-O
+variants NOUN B-O
+in ADP B-O
+Histone NOUN B-LF
+- NOUN I-LF
+lysine NOUN I-LF
+N NOUN I-LF
+- NOUN I-LF
+methyltransferase NOUN I-LF
+2D PROPN I-LF
+( PUNCT B-O
+KMT2D PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+causative ADJ B-O
+in ADP B-O
+up ADP B-O
+to PART B-O
+76 NUM B-O
+% NOUN B-O
+of ADP B-O
+KS PROPN B-O
+patients NOUN B-O
+[ PUNCT B-O
+18,19 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+* PUNCT B-O
+Reproductive ADJ B-O
+/ SYM B-O
+antenatal ADJ B-O
+health NOUN B-O
+: PUNCT B-O
+Reproductive ADJ B-O
+/ SYM B-O
+antenatal ADJ B-O
+knowledge NOUN B-O
+, PUNCT B-O
+medical ADJ B-O
+abortion NOUN B-O
+, PUNCT B-O
+facility NOUN B-O
+delivery NOUN B-O
+, PUNCT B-O
+child NOUN B-O
+dietary ADJ B-O
+diversity NOUN B-O
+. PUNCT B-O
+
+†Non ADJ B-O
+- ADJ I-LF
+communicable ADJ I-LF
+diseases NOUN I-LF
+: PUNCT B-O
+Diabetes NOUN B-O
+, PUNCT B-O
+hypertension NOUN B-O
+. PUNCT B-O
+
+‡One NUM B-O
+ongoing ADJ B-O
+NCD PROPN B-AC
+trial NOUN B-O
+is AUX B-O
+a DET B-O
+multicenter NOUN B-O
+study NOUN B-O
+in ADP B-O
+South PROPN B-O
+Africa PROPN B-O
+and CCONJ B-O
+Malawi PROPN B-O
+, PUNCT B-O
+hence ADV B-O
+the DET B-O
+number NOUN B-O
+of ADP B-O
+symbols NOUN B-O
+exceeds VERB B-O
+the DET B-O
+number NOUN B-O
+of ADP B-O
+included VERB B-O
+trials NOUN B-O
+by ADP B-O
+one NUM B-O
+. PUNCT B-O
+
+§ PUNCT B-O
+Map NOUN B-O
+developed VERB B-O
+by ADP B-O
+use NOUN B-O
+of ADP B-O
+mapchart.net NOUN B-O
+. PUNCT B-O
+
+Phase NOUN B-O
+contrast NOUN B-O
+cine NOUN B-O
+gradient NOUN B-O
+echo NOUN B-O
+sequence NOUN B-O
+was AUX B-O
+also ADV B-O
+obtained VERB B-O
+to PART B-O
+evaluate VERB B-O
+aortic ADJ B-O
+stiffness NOUN B-O
+including VERB B-O
+ascending VERB B-O
+and CCONJ B-O
+descending ADJ B-LF
+aortic ADJ I-LF
+distensibility NOUN I-LF
+( PUNCT B-O
+AAD NOUN B-O
+and CCONJ B-O
+DAD PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+pulse NOUN B-LF
+wave NOUN I-LF
+velocity NOUN I-LF
+( PUNCT B-O
+PWV PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+16 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Streptokinase PROPN B-O
+was AUX B-O
+administered VERB B-O
+in ADP B-O
+seven NUM B-O
+( PUNCT B-O
+6.3 NUM B-O
+% NOUN B-O
+) NOUN B-O
+patients NOUN B-O
+with ADP B-O
+STEMI PROPN B-AC
+. PUNCT B-O
+
+Primary ADJ B-O
+percutaneous ADJ B-LF
+coronary ADJ I-LF
+intervention NOUN I-LF
+( PUNCT B-O
+PCI PROPN B-AC
+) NOUN B-O
+was AUX B-O
+done VERB B-O
+in ADP B-O
+six NUM B-O
+( PUNCT B-O
+3.9 NUM B-O
+% NOUN B-O
+) NOUN B-O
+patients NOUN B-O
+with ADP B-O
+STEMI PROPN B-AC
+. PUNCT B-O
+
+Loading VERB B-O
+dose NOUN B-O
+of ADP B-O
+aspirin NOUN B-O
+and CCONJ B-O
+clopidogrel NOUN B-O
+were AUX B-O
+administered VERB B-O
+in ADP B-O
+the DET B-O
+emergency NOUN B-O
+setting NOUN B-O
+in ADP B-O
+about ADV B-O
+63.8 NUM B-O
+% NOUN B-O
+and CCONJ B-O
+62.8 NUM B-O
+% NOUN B-O
+of ADP B-O
+patients NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+Overall ADJ B-O
+and CCONJ B-O
+age NOUN B-O
+- ADJ B-O
+specific ADJ B-O
+meta ADJ B-O
+- ADJ B-O
+analytic ADJ B-O
+estimates NOUN B-O
+of ADP B-O
+proportion NOUN B-O
+positive ADJ B-O
+were AUX B-O
+multiplied VERB B-O
+by ADP B-O
+LRI PROPN B-AC
+hospitalization NOUN B-O
+and CCONJ B-O
+LRI PROPN B-AC
+episode NOUN B-O
+estimates NOUN B-O
+for ADP B-O
+adults NOUN B-O
+≥20 NUM B-O
+years NOUN B-O
+, PUNCT B-O
+which PRON B-O
+were AUX B-O
+from ADP B-O
+the DET B-O
+Global PROPN B-LF
+Burden PROPN I-LF
+of ADP I-LF
+Disease PROPN I-LF
+( PUNCT B-O
+GBD PROPN B-AC
+) PUNCT B-O
+2017 NUM B-O
+study NOUN B-O
+[ PUNCT B-O
+10 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+obtained VERB B-O
+for ADP B-O
+calendar NOUN B-O
+year NOUN B-O
+2016 NUM B-O
+for ADP B-O
+this DET B-O
+analysis NOUN B-O
+. PUNCT B-O
+
+cART PROPN B-AC
+, PUNCT B-O
+combined ADJ B-O
+antiretroviral ADJ B-O
+therapy NOUN B-O
+; PUNCT B-O
+CI PROPN B-O
+, PUNCT B-O
+confidence NOUN B-O
+interval NOUN B-O
+; PUNCT B-O
+DTG PROPN B-AC
+, PUNCT B-O
+dolutegravir NOUN B-LF
+; PUNCT B-O
+FTC PROPN B-AC
+, PUNCT B-O
+emtricitabine NOUN B-LF
+; PUNCT B-O
+ITT PROPN B-AC
+, PUNCT B-O
+intention NOUN B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+treat VERB I-LF
+; PUNCT B-O
+PP PROPN B-AC
+, PUNCT B-O
+per ADP B-O
+- PUNCT B-O
+protocol NOUN B-O
+. PUNCT B-O
+
+People NOUN B-O
+with ADP B-O
+mental ADJ B-O
+illnesses NOUN B-O
+: PUNCT B-O
+Patients NOUN B-O
+under ADP B-O
+psychiatric ADJ B-O
+medications NOUN B-O
+for ADP B-O
+mental ADJ B-O
+illnesses NOUN B-O
+whose DET B-O
+identity NOUN B-O
+were AUX B-O
+informed VERB B-O
+by ADP B-O
+Female PROPN B-LF
+Community PROPN I-LF
+Health PROPN I-LF
+Volunteers PROPN I-LF
+( PUNCT B-O
+FCHVs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+PHC PROPN B-AC
+health NOUN B-O
+workers NOUN B-O
+or CCONJ B-O
+secondary ADJ B-O
+health NOUN B-O
+service NOUN B-O
+providers NOUN B-O
+. PUNCT B-O
+
+Wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+( PUNCT B-O
+WT PROPN B-AC
+) PUNCT B-O
+CD45.1 NOUN B-O
+and CCONJ B-O
+CD45.2 NOUN B-O
+mice NOUN B-O
+were AUX B-O
+bred VERB B-O
+and CCONJ B-O
+maintained VERB B-O
+in ADP B-O
+conventional ADJ B-O
+pathogen NOUN B-O
+- PUNCT B-O
+free ADJ B-O
+colonies NOUN B-O
+at ADP B-O
+either CCONJ B-O
+the DET B-O
+National PROPN B-O
+Institute PROPN B-O
+for ADP B-O
+Medical PROPN B-O
+Research PROPN B-O
+( PUNCT B-O
+London PROPN B-O
+, PUNCT B-O
+United PROPN B-O
+Kingdom PROPN B-O
+) PUNCT B-O
+or CCONJ B-O
+at ADP B-O
+the DET B-O
+Royal PROPN B-O
+Free PROPN B-O
+Campus PROPN B-O
+of ADP B-O
+University PROPN B-O
+College PROPN B-O
+London PROPN B-O
+. PUNCT B-O
+
+We PRON B-O
+undertook VERB B-O
+meta NOUN B-O
+- PUNCT B-O
+analyses NOUN B-O
+using VERB B-O
+RevMan PROPN B-O
+5.3 NUM B-O
+[ X B-O
+30 NUM B-O
+] X B-O
+using VERB B-O
+random ADJ B-O
+- PUNCT B-O
+effects NOUN B-O
+models NOUN B-O
+and CCONJ B-O
+calculated VERB B-O
+relative ADJ B-LF
+risks NOUN I-LF
+( PUNCT B-O
+RRs PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+mean ADJ B-LF
+differences NOUN I-LF
+( PUNCT B-O
+MDs PROPN B-AC
+) PUNCT B-O
+with ADP B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT B-O
+CIs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+quantify VERB B-O
+time NOUN B-O
+- PUNCT B-O
+dependent ADJ B-O
+changes NOUN B-O
+in ADP B-O
+synaptic ADJ B-O
+gain NOUN B-O
+we PRON B-O
+used VERB B-O
+an DET B-O
+“ PUNCT B-O
+Adaptation PROPN B-LF
+Index PROPN I-LF
+” PUNCT B-O
+( PUNCT B-O
+AI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+calculated VERB B-O
+as ADP B-O
+the DET B-O
+ratio NOUN B-O
+between ADP B-O
+the DET B-O
+peak ADJ B-O
+initial ADJ B-O
+response NOUN B-O
+to ADP B-O
+an DET B-O
+increase NOUN B-O
+in ADP B-O
+contrast NOUN B-O
+and CCONJ B-O
+the DET B-O
+later ADJ B-O
+steady ADJ B-O
+- PUNCT B-O
+state NOUN B-O
+response NOUN B-O
+. PUNCT B-O
+
+During ADP B-O
+the DET B-O
+course NOUN B-O
+of ADP B-O
+this DET B-O
+study NOUN B-O
+, PUNCT B-O
+an DET B-O
+updated VERB B-O
+, PUNCT B-O
+larger ADJ B-O
+GWAS PROPN B-AC
+dataset NOUN B-O
+for ADP B-O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+CAD PROPN B-AC
+) PUNCT B-O
+became VERB B-O
+publicly ADV B-O
+available ADJ B-O
+( PUNCT B-O
+CARDIoGRAMplusC4D PROPN B-O
+Consortium PROPN B-O
+, PUNCT B-O
+release NOUN B-O
+2015 NUM B-O
+[ X B-O
+41 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+; PUNCT B-O
+we PRON B-O
+therefore ADV B-O
+redid VERB B-O
+the DET B-O
+analysis NOUN B-O
+for ADP B-O
+CAD PROPN B-AC
+using VERB B-O
+the DET B-O
+release NOUN B-O
+2015 NUM B-O
+data NOUN B-O
+. PUNCT B-O
+
+Rate NOUN B-O
+ratio NOUN B-O
+( PUNCT B-O
+RR NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+credible ADJ B-LF
+interval NOUN I-LF
+( PUNCT B-O
+CrI PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+brackets NOUN B-O
+, PUNCT B-O
+significant ADJ B-O
+predictions NOUN B-O
+in ADP B-O
+bold NOUN B-O
+. PUNCT B-O
+
+To PART B-O
+analyze VERB B-O
+the DET B-O
+amount NOUN B-O
+of ADP B-O
+asymmetry NOUN B-O
+between ADP B-O
+the DET B-O
+dominant ADJ B-O
+and CCONJ B-O
+non ADJ B-O
+- ADJ B-O
+dominant ADJ B-O
+lower ADJ B-O
+limbs NOUN B-O
+, PUNCT B-O
+we PRON B-O
+used VERB B-O
+the DET B-O
+absolute ADJ B-LF
+symmetry NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+ASI PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+symmetry NOUN B-LF
+index NOUN I-LF
+( PUNCT B-O
+SI PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+31–34 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+This DET B-O
+method NOUN B-O
+, PUNCT B-O
+called VERB B-O
+optimal ADJ B-LF
+metabolic ADJ I-LF
+network NOUN I-LF
+identification NOUN I-LF
+( PUNCT B-O
+OMNI PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+allows VERB B-O
+efficient ADJ B-O
+identification NOUN B-O
+of ADP B-O
+the DET B-O
+set NOUN B-O
+of ADP B-O
+reactions NOUN B-O
+that PRON B-O
+results VERB B-O
+in ADP B-O
+the DET B-O
+best ADJ B-O
+agreement NOUN B-O
+between ADP B-O
+in ADP B-O
+silico NOUN B-O
+predicted VERB B-O
+and CCONJ B-O
+experimentally ADV B-O
+measured VERB B-O
+flux NOUN B-O
+distributions NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+then ADV B-O
+removed VERB B-O
+any DET B-O
+variants NOUN B-O
+with ADP B-O
+flags NOUN B-O
+“ PUNCT B-O
+badRead ADJ B-O
+, PUNCT B-O
+” PUNCT B-O
+mapping NOUN B-LF
+quality NOUN I-LF
+( PUNCT B-O
+“ PUNCT B-O
+MQ PROPN B-AC
+” PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+quality NOUN B-LF
+depth NOUN I-LF
+( PUNCT B-O
+“ PUNCT B-O
+QD PROPN B-AC
+” PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+After ADP B-O
+fixation NOUN B-O
+and CCONJ B-O
+permeabilization NOUN B-O
+, PUNCT B-O
+the DET B-O
+cells NOUN B-O
+were AUX B-O
+stained VERB B-O
+for ADP B-O
+pSHIP PROPN B-AC
+and CCONJ B-O
+analyzed VERB B-O
+using VERB B-O
+confocal ADJ B-LF
+microscopy NOUN I-LF
+( PUNCT B-O
+CFm PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+flow NOUN B-O
+cytometry NOUN B-O
+( PUNCT B-O
+A NOUN B-O
+, PUNCT B-O
+B NOUN B-O
+and CCONJ B-O
+D NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+mean ADJ B-LF
+fluorescence NOUN I-LF
+intensity NOUN I-LF
+( PUNCT B-O
+MFI PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+pSHIP PROPN B-AC
+was AUX B-O
+generated VERB B-O
+using VERB B-O
+NIS PROPN B-O
+- PUNCT B-O
+Elements PROPN B-O
+AR PROPN B-O
+3.2 NUM B-O
+software NOUN B-O
+( PUNCT B-O
+C NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Flow NOUN B-O
+cytometry NOUN B-O
+analysis NOUN B-O
+of ADP B-O
+the DET B-O
+MFI PROPN B-AC
+of ADP B-O
+pSHIP PROPN B-AC
+after ADP B-O
+stimulation NOUN B-O
+with ADP B-O
+sAgs PROPN B-AC
+( PUNCT B-O
+D NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+Pearson PROPN B-O
+’s PART B-O
+correlation NOUN B-O
+coefficients NOUN B-O
+between ADP B-O
+BCR PROPN B-AC
+and CCONJ B-O
+pSHIP PROPN B-AC
+staining NOUN B-O
+in ADP B-O
+sAg PROPN B-AC
+- PUNCT B-O
+stimulated VERB B-O
+cells NOUN B-O
+were AUX B-O
+determined VERB B-O
+using VERB B-O
+NIS PROPN B-O
+- PUNCT B-O
+Elements PROPN B-O
+AR PROPN B-O
+3.2 NUM B-O
+software NOUN B-O
+( PUNCT B-O
+E NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Shown VERB B-O
+are AUX B-O
+representative ADJ B-O
+images NOUN B-O
+at ADP B-O
+indicated VERB B-O
+times NOUN B-O
+and CCONJ B-O
+the DET B-O
+average ADJ B-O
+values NOUN B-O
+( PUNCT B-O
+±SD NOUN B-O
+) PUNCT B-O
+of ADP B-O
+about ADV B-O
+50 NUM B-O
+cells NOUN B-O
+from ADP B-O
+3 NUM B-O
+independent ADJ B-O
+experiments NOUN B-O
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+higher ADJ B-O
+prevalence NOUN B-O
+of ADP B-O
+tumor NOUN B-LF
+- PUNCT I-LF
+infiltrating VERB I-LF
+lymphocytes NOUN I-LF
+( PUNCT B-O
+TILs PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+been AUX B-O
+associated VERB B-O
+with ADP B-O
+better ADJ B-O
+prognosis NOUN B-O
+[ PUNCT B-O
+19–22 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+irrespective ADV B-O
+of ADP B-O
+the DET B-O
+chemotherapy NOUN B-O
+administered VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+also ADV B-O
+with ADP B-O
+a DET B-O
+higher ADJ B-O
+rate NOUN B-O
+of ADP B-O
+pCR PROPN B-AC
+to ADP B-O
+neoadjuvant ADJ B-O
+anthracycline NOUN B-O
+- PUNCT B-O
+based VERB B-O
+chemotherapy NOUN B-O
+in ADP B-O
+TNBC PROPN B-AC
+[ PUNCT B-O
+23 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+To PART B-O
+address VERB B-O
+this DET B-O
+question NOUN B-O
+, PUNCT B-O
+hairpin NOUN B-O
+RNA NOUN B-LF
+- PUNCT I-LF
+induced VERB I-LF
+gene NOUN I-LF
+silencing NOUN I-LF
+( PUNCT B-O
+RNAi PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+adopted VERB B-O
+. PUNCT B-O
+
+The DET B-O
+first ADJ B-O
+antimetabolite NOUN B-O
+drug NOUN B-O
+that PRON B-O
+was AUX B-O
+developed VERB B-O
+to PART B-O
+specifically ADV B-O
+target VERB B-O
+cancer NOUN B-O
+cells NOUN B-O
+was AUX B-O
+the DET B-O
+pyrimidine NOUN B-O
+analogue NOUN B-O
+5 NUM B-LF
+- PUNCT I-LF
+fluorouracil NOUN I-LF
+, PUNCT B-O
+5-FU PROPN B-AC
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+5 PROPN B-AC
+targets VERB B-O
+several ADJ B-O
+cellular ADJ B-O
+mechanisms NOUN B-O
+through ADP B-O
+its PRON B-O
+activated VERB B-O
+metabolites NOUN B-O
+FdUMP NOUN B-O
+, PUNCT B-O
+FUTP PROPN B-O
+and CCONJ B-O
+FdUTP NOUN B-O
+[ PUNCT B-O
+2–3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Cb PROPN B-O
+, PUNCT B-O
+Coxiella PROPN B-O
+burnetii NOUN B-O
+; PUNCT B-O
+GO PROPN B-AC
+, PUNCT B-O
+Gene PROPN B-LF
+Ontology NOUN I-LF
+; PUNCT B-O
+praw NOUN B-O
+, PUNCT B-O
+original ADJ B-O
+p NOUN B-O
+- PUNCT B-O
+value NOUN B-O
+; PUNCT B-O
+padj NOUN B-O
+, PUNCT B-O
+adjusted VERB B-O
+p NOUN B-O
+- PUNCT B-O
+value NOUN B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+Benjamini PROPN B-O
+- PUNCT B-O
+Hochberg PROPN B-O
+multiple ADJ B-O
+test NOUN B-O
+correction NOUN B-O
+[ PUNCT B-O
+43 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+conceptus NOUN B-O
+was AUX B-O
+dissected VERB B-O
+, PUNCT B-O
+and CCONJ B-O
+transcriptome NOUN B-O
+data NOUN B-O
+were AUX B-O
+generated VERB B-O
+for ADP B-O
+extraembryonic ADJ B-O
+tissue NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+the DET B-O
+endometrium NOUN B-O
+was AUX B-O
+dissected VERB B-O
+into ADP B-O
+caruncular ADJ B-O
+( PUNCT B-O
+gland NOUN B-O
+- PUNCT B-O
+free ADJ B-O
+) PUNCT B-O
+and CCONJ B-O
+intercaruncular ADJ B-O
+( PUNCT B-O
+containing VERB B-O
+endometrial ADJ B-O
+glands NOUN B-O
+) PUNCT B-O
+areas NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+transcriptome NOUN B-O
+data NOUN B-O
+were AUX B-O
+generated VERB B-O
+from ADP B-O
+both DET B-O
+regions NOUN B-O
+of ADP B-O
+the DET B-O
+endometrium NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+1A NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Therefore ADV B-O
+, PUNCT B-O
+the DET B-O
+data NOUN B-O
+set NOUN B-O
+analyzed VERB B-O
+was AUX B-O
+comprised VERB B-O
+of ADP B-O
+three NUM B-O
+sample NOUN B-O
+types NOUN B-O
+collected VERB B-O
+from ADP B-O
+each DET B-O
+pregnancy NOUN B-O
+: PUNCT B-O
+extraembryonic ADJ B-O
+, PUNCT B-O
+caruncular ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+intercaruncular ADJ B-O
+tissues NOUN B-O
+( PUNCT B-O
+Fig NOUN B-O
+1B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Alignment NOUN B-O
+of ADP B-O
+the DET B-O
+sequences NOUN B-O
+to ADP B-O
+the DET B-O
+B. PROPN B-O
+taurus PROPN B-O
+genome NOUN B-O
+( PUNCT B-O
+University PROPN B-LF
+of ADP I-LF
+Maryland PROPN I-LF
+[ X B-O
+UMD PROPN B-AC
+] X B-O
+assembly NOUN B-O
+3.1 NUM B-O
+) PUNCT B-O
+resulted VERB B-O
+into ADP B-O
+an DET B-O
+average NOUN B-O
+of ADP B-O
+22 NUM B-O
+, PUNCT B-O
+31.4 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+34.6 NUM B-O
+million NUM B-O
+uniquely ADV B-O
+mapped VERB B-O
+reads NOUN B-O
+for ADP B-O
+extraembryonic ADJ B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+5 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+caruncular ADJ B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+5 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+intercaruncular ADJ B-O
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+5 NUM B-O
+) PUNCT B-O
+tissues NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+Hormone NOUN B-LF
+therapy NOUN I-LF
+( PUNCT B-O
+HT PROPN B-AC
+) PUNCT B-O
+may AUX B-O
+decrease VERB B-O
+the DET B-O
+risk NOUN B-O
+of ADP B-O
+osteoporosis NOUN B-O
+and CCONJ B-O
+bone NOUN B-O
+fracture NOUN B-O
+[ PUNCT B-O
+31 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+review NOUN B-O
+is AUX B-O
+reported VERB B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+Preferred ADJ B-LF
+Reporting PROPN I-LF
+Items PROPN I-LF
+for ADP I-LF
+Systematic PROPN I-LF
+Reviews PROPN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PROPN I-LF
+Analyses PROPN I-LF
+( PUNCT B-O
+PRISMA PROPN B-AC
+) PUNCT B-O
+[ X B-O
+19 X B-O
+] PUNCT B-O
+( PUNCT B-O
+see VERB B-O
+S1 PROPN B-O
+Checklist PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+Guidelines PROPN B-O
+for ADP B-O
+Meta PROPN B-O
+- PROPN B-O
+Analyses PROPN B-O
+and CCONJ B-O
+Systematic PROPN B-O
+Reviews PROPN B-O
+of ADP B-O
+Observational PROPN B-O
+Studies.[20 PROPN B-O
+] PUNCT B-O
+The DET B-O
+protocol NOUN B-O
+was AUX B-O
+published VERB B-O
+in ADP B-O
+advance NOUN B-O
+( PUNCT B-O
+ID NOUN B-O
+= X B-O
+CRD42015025488).[21 NUM B-O
+] PUNCT B-O
+Eligibility NOUN B-O
+criteria NOUN B-O
+were AUX B-O
+defined VERB B-O
+in ADP B-O
+relation NOUN B-O
+to ADP B-O
+PICOS PROPN B-AC
+( PUNCT B-O
+participants NOUN B-LF
+, PUNCT I-LF
+interventions NOUN I-LF
+, PUNCT I-LF
+comparisons NOUN I-LF
+, PUNCT I-LF
+outcomes NOUN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+study NOUN I-LF
+design NOUN I-LF
+) PUNCT B-O
+as SCONJ B-O
+recommended VERB B-O
+by ADP B-O
+PRISMA PROPN B-AC
+. PUNCT B-O
+
+In ADP B-O
+this DET B-O
+study NOUN B-O
+, PUNCT B-O
+we PRON B-O
+assembled VERB B-O
+a DET B-O
+large ADJ B-O
+array NOUN B-O
+of ADP B-O
+variables NOUN B-O
+from ADP B-O
+4 NUM B-O
+components NOUN B-O
+within ADP B-O
+HRS PROPN B-AC
+, PUNCT B-O
+including VERB B-O
+the DET B-O
+core NOUN B-O
+survey NOUN B-O
+( PUNCT B-O
+1996–2016 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+newly ADV B-O
+released VERB B-O
+2015 NUM B-O
+Life PROPN B-LF
+History PROPN I-LF
+Mail PROPN I-LF
+Survey PROPN I-LF
+( PUNCT B-O
+LHMS PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+Enhanced PROPN B-LF
+Face PROPN I-LF
+- PUNCT I-LF
+To ADP I-LF
+- PUNCT I-LF
+Face PROPN I-LF
+( PUNCT B-O
+EFTF PROPN B-AC
+) PUNCT B-O
+interview NOUN B-O
+( PUNCT B-O
+2006–2016 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+2016 NUM B-O
+Venous PROPN B-LF
+Blood PROPN I-LF
+Study PROPN I-LF
+( PUNCT B-O
+VBS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+description NOUN B-O
+of ADP B-O
+the DET B-O
+4 NUM B-O
+data NOUN B-O
+sources NOUN B-O
+can AUX B-O
+be AUX B-O
+found VERB B-O
+in ADP B-O
+S1 PROPN B-O
+Appendix PROPN B-O
+and CCONJ B-O
+elsewhere ADV B-O
+[ PUNCT B-O
+31 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+A DET B-O
+plot NOUN B-O
+of ADP B-O
+the DET B-O
+total ADJ B-O
+median ADJ B-LF
+p-Stat5 PROPN B-AC
+fluorescence NOUN I-LF
+intensity NOUN I-LF
+( PUNCT B-O
+MFI PROPN B-AC
+) PUNCT B-O
+versus ADP B-O
+Epo PROPN B-AC
+concentration NOUN B-O
+has VERB B-O
+Michaelian ADJ B-O
+kinetics NOUN B-O
+with ADP B-O
+a DET B-O
+Hill PROPN B-LF
+coefficient NOUN I-LF
+( PUNCT B-O
+nH PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+1 NUM B-O
+( PUNCT B-O
+lower ADJ B-O
+left ADJ B-O
+panel NOUN B-O
+, PUNCT B-O
+please INTJ B-O
+note VERB B-O
+a DET B-O
+log NOUN B-O
+scale NOUN B-O
+was AUX B-O
+used VERB B-O
+for ADP B-O
+the DET B-O
+x NOUN B-O
+- NOUN B-O
+axis NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+A X B-O
+: PUNCT B-O
+Flow NOUN B-O
+cytometry NOUN B-O
+of ADP B-O
+patient ADJ B-O
+P3 NOUN B-O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT B-O
+PBMC PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+left ADJ B-O
+column NOUN B-O
+) PUNCT B-O
+followed VERB B-O
+by ADP B-O
+cell NOUN B-O
+sorting NOUN B-O
+of ADP B-O
+TCRVβ22 NOUN B-O
++ ADJ B-O
+tumor NOUN B-O
+cells NOUN B-O
+( PUNCT B-O
+median ADJ B-O
+column NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+non ADJ B-O
+- ADJ B-O
+TCRVβ22 NOUN B-O
++ ADJ B-O
+cells NOUN B-O
+( PUNCT B-O
+right ADJ B-O
+column NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+STAT2 PROPN B-O
+is AUX B-O
+the DET B-O
+quintessential ADJ B-O
+transcription NOUN B-O
+factor NOUN B-O
+for ADP B-O
+type NOUN B-O
+1 NUM B-O
+interferons NOUN B-LF
+( PUNCT B-O
+IFNs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+where SCONJ B-O
+it PRON B-O
+functions VERB B-O
+as ADP B-O
+a DET B-O
+heterodimer NOUN B-O
+with ADP B-O
+STAT1 PROPN B-O
+. PUNCT B-O
+
+However ADV B-O
+, PUNCT B-O
+the DET B-O
+human ADJ B-O
+and CCONJ B-O
+murine ADJ B-O
+STAT2 PROPN B-O
+- PUNCT B-O
+deficient ADJ B-O
+phenotypes NOUN B-O
+suggest VERB B-O
+important ADJ B-O
+additional ADJ B-O
+and CCONJ B-O
+currently ADV B-O
+unidentified ADJ B-O
+type NOUN B-O
+1 NUM B-O
+IFN PROPN B-AC
+- PUNCT B-O
+independent ADJ B-O
+activities NOUN B-O
+. PUNCT B-O
+
+We PRON B-O
+performed VERB B-O
+the DET B-O
+present ADJ B-O
+exclusive ADJ B-O
+study NOUN B-O
+to PART B-O
+investigate VERB B-O
+the DET B-O
+associations NOUN B-O
+between ADP B-O
+a DET B-O
+total NOUN B-O
+of ADP B-O
+9 NUM B-O
+static ADJ B-O
+and CCONJ B-O
+14 NUM B-O
+dynamic ADJ B-O
+lactate NOUN B-O
+indices NOUN B-O
+during ADP B-O
+the DET B-O
+first ADJ B-O
+24h NUM B-O
+of ADP B-O
+an DET B-O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+( PUNCT B-O
+ICU PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+- PUNCT B-O
+hospital NOUN B-O
+mortality NOUN B-O
+in ADP B-O
+unselected ADJ B-O
+ICU PROPN B-AC
+patients NOUN B-O
+. PUNCT B-O
+
+Since SCONJ B-O
+selective ADJ B-O
+serotonin NOUN B-O
+reuptake NOUN B-O
+inhibitors NOUN B-O
+( PUNCT B-O
+SSRIs PROPN B-O
+) PUNCT B-O
+such ADJ B-O
+as ADP B-O
+fluvoxamine NOUN B-O
+and CCONJ B-O
+sertraline NOUN B-O
+are AUX B-O
+potent ADJ B-O
+σ1R NOUN B-O
+ligands NOUN B-O
+, PUNCT B-O
+we PRON B-O
+recently ADV B-O
+focused VERB B-O
+on ADP B-O
+cardioprotective ADJ B-O
+mechanisms NOUN B-O
+of ADP B-O
+SSRI PROPN B-O
+through ADP B-O
+the DET B-O
+σ1R NOUN B-O
+in ADP B-O
+heart NOUN B-O
+failure NOUN B-O
+models NOUN B-O
+using VERB B-O
+transverse ADJ B-LF
+aortic ADJ I-LF
+constriction NOUN I-LF
+( PUNCT B-O
+TAC PROPN B-AC
+) PUNCT B-O
+mice NOUN B-O
+and CCONJ B-O
+ovariectomised ADJ B-O
+rats NOUN B-O
+[ PUNCT B-O
+5–7 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+we PRON B-O
+used VERB B-O
+unilateral ADJ B-O
+and CCONJ B-O
+bilateral ADJ B-O
+reversible ADJ B-O
+inactivation NOUN B-O
+of ADP B-O
+the DET B-O
+frontal ADJ B-LF
+eye NOUN I-LF
+fields NOUN I-LF
+( PUNCT B-O
+FEF PROPN B-AC
+) PUNCT B-O
+to PART B-O
+identify VERB B-O
+a DET B-O
+cortical ADJ B-O
+drive NOUN B-O
+for ADP B-O
+microsaccades NOUN B-O
+. PUNCT B-O
+
+Ten NUM B-O
+- PUNCT B-O
+week NOUN B-O
+- PUNCT B-O
+old ADJ B-O
+C57BL/6 PROPN B-O
+male ADJ B-O
+mice NOUN B-O
+( PUNCT B-O
+purchased VERB B-O
+from ADP B-O
+Taconic PROPN B-O
+, PUNCT B-O
+Ry PROPN B-O
+, PUNCT B-O
+Denmark PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+allowed VERB B-O
+one NUM B-O
+week NOUN B-O
+of ADP B-O
+acclimatization NOUN B-O
+on ADP B-O
+chow NOUN B-O
+diet NOUN B-O
+before ADP B-O
+study NOUN B-O
+start NOUN B-O
+) PUNCT B-O
+were AUX B-O
+fed VERB B-O
+either CCONJ B-O
+a DET B-O
+high ADJ B-O
+fat NOUN B-O
+control NOUN B-O
+diet NOUN B-O
+( PUNCT B-O
+HFD PROPN B-AC
+, PUNCT B-O
+n NOUN B-O
+= SYM B-O
+9 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+a DET B-O
+high ADJ B-LF
+fat NOUN I-LF
+diet NOUN I-LF
+containing VERB B-O
+0.75 NUM B-O
+% NOUN B-O
+TTA PROPN B-AC
+( PUNCT B-O
+n NOUN B-O
+= SYM B-O
+9 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+water NOUN B-O
+ad X B-O
+libitum X B-O
+for ADP B-O
+6 NUM B-O
+weeks NOUN B-O
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+rates NOUN B-O
+of ADP B-O
+new ADJ B-O
+hepatitis NOUN B-LF
+C PROPN I-LF
+virus NOUN I-LF
+( PUNCT B-O
+HCV PROPN B-AC
+) PUNCT B-O
+infection NOUN B-O
+are AUX B-O
+on ADP B-O
+the DET B-O
+rise NOUN B-O
+due ADP B-O
+to ADP B-O
+the DET B-O
+ongoing ADJ B-O
+epidemic NOUN B-O
+of ADP B-O
+injection NOUN B-O
+drug NOUN B-O
+use NOUN B-O
+. PUNCT B-O
+
+It PRON B-O
+was AUX B-O
+found VERB B-O
+that SCONJ B-O
+an DET B-O
+increase NOUN B-O
+in ADP B-O
+the DET B-O
+optical ADJ B-LF
+density NOUN I-LF
+( PUNCT B-O
+OD PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+the DET B-O
+formazan NOUN B-O
+dye NOUN B-O
+directly ADV B-O
+correlates VERB B-O
+with ADP B-O
+the DET B-O
+metabolic ADJ B-O
+activity NOUN B-O
+of ADP B-O
+the DET B-O
+cells NOUN B-O
+following VERB B-O
+exposure NOUN B-O
+to ADP B-O
+either CCONJ B-O
+Pt PROPN B-AC
+or CCONJ B-O
+-DissPt PROPN B-AC
+. PUNCT B-O
+
+For ADP B-O
+measurement NOUN B-O
+of ADP B-O
+the DET B-O
+formazan NOUN B-O
+dye NOUN B-O
+intensities NOUN B-O
+, PUNCT B-O
+the DET B-O
+cell NOUN B-O
+culture NOUN B-O
+medium NOUN B-O
+was AUX B-O
+exchanged VERB B-O
+with ADP B-O
+those PRON B-O
+containing VERB B-O
+WST-1 NOUN B-O
+solution NOUN B-O
+at ADP B-O
+the DET B-O
+final ADJ B-O
+concentration NOUN B-O
+of ADP B-O
+1 NUM B-O
+mg NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+. PUNCT B-O
+
+Further ADV B-O
+, PUNCT B-O
+1,377 NUM B-O
+of ADP B-O
+these DET B-O
+windows NOUN B-O
+overlapped VERB B-O
+with ADP B-O
+the DET B-O
+transcription NOUN B-O
+start NOUN B-O
+site NOUN B-O
+or CCONJ B-O
+gene NOUN B-O
+body NOUN B-O
+of ADP B-O
+766 NUM B-O
+independent ADJ B-O
+genes NOUN B-O
+in ADP B-O
+Suz12 PROPN B-AC
+- PUNCT B-O
+deleted VERB B-O
+basal ADJ B-O
+organoids NOUN B-O
+( PUNCT B-O
+referred VERB B-O
+to ADP B-O
+as ADP B-O
+differentially ADV B-LF
+accessible ADJ I-LF
+[ X B-O
+DA PROPN B-AC
+] X B-O
+genes NOUN B-O
+from ADP B-O
+hereon ADV B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Biopharmaceutical ADJ B-LF
+products NOUN I-LF
+( PUNCT B-O
+BPs PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+widely ADV B-O
+used VERB B-O
+to PART B-O
+treat VERB B-O
+autoimmune ADJ B-O
+diseases NOUN B-O
+, PUNCT B-O
+but CCONJ B-O
+immunogenicity NOUN B-O
+limits VERB B-O
+their PRON B-O
+efficacy NOUN B-O
+for ADP B-O
+an DET B-O
+important ADJ B-O
+proportion NOUN B-O
+of ADP B-O
+patients NOUN B-O
+. PUNCT B-O
+
+ATc PROPN B-AC
+, PUNCT B-O
+anhydrotetracycline NOUN B-LF
+; PUNCT B-O
+GCaMP6 PROPN B-AC
+, PUNCT B-O
+GFP NOUN B-LF
+- PUNCT I-LF
+GFP PROPN B-AC
+Calmodulin NOUN I-LF
+- PUNCT I-LF
+M13 NOUN I-LF
+- PUNCT I-LF
+peptide-6 NOUN I-LF
+. PUNCT B-O
+
+To ADP B-O
+this DET B-O
+day NOUN B-O
+, PUNCT B-O
+vertebrate ADJ B-O
+prion NOUN B-LF
+proteins NOUN I-LF
+exhibit VERB B-O
+profound ADJ B-O
+sequence NOUN B-O
+similarities NOUN B-O
+to ADP B-O
+the DET B-O
+subbranch NOUN B-O
+of ADP B-O
+ZIP PROPN B-O
+zinc NOUN B-O
+transporters NOUN B-O
+comprising VERB B-O
+ZIP5 NUM B-O
+, PUNCT B-O
+ZIP6 PROPN B-O
+and CCONJ B-O
+ZIP10 NOUN B-O
+[ PUNCT B-O
+2 NUM B-O
+, PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+highly ADV B-O
+similar ADJ B-O
+defects NOUN B-O
+in ADP B-O
+the DET B-O
+execution NOUN B-O
+of ADP B-O
+a DET B-O
+morphogenetic ADJ B-O
+program NOUN B-O
+, PUNCT B-O
+known VERB B-O
+as ADP B-O
+epithelial ADJ B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+mesenchymal ADJ I-LF
+transition NOUN I-LF
+( PUNCT B-O
+EMT PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+4 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+have AUX B-O
+been AUX B-O
+reported VERB B-O
+for ADP B-O
+zebrafish NOUN B-O
+embryos NOUN B-O
+deficient ADJ B-O
+in ADP B-O
+ZIP6 PROPN B-O
+[ PUNCT B-O
+5 NUM B-O
+] PUNCT B-O
+or CCONJ B-O
+PrP PROPN B-AC
+[ PUNCT B-O
+6 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+On ADP B-O
+17 NUM B-O
+days NOUN B-LF
+of ADP I-LF
+gestation NOUN I-LF
+( PUNCT B-O
+17-DG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+dams NOUN B-O
+were AUX B-O
+anesthetized VERB B-O
+by ADP B-O
+ketamine NOUN B-O
+( PUNCT B-O
+75mg NUM B-O
+/ SYM B-O
+kg NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+xylazine NOUN B-O
+( PUNCT B-O
+10mg NUM B-O
+/ SYM B-O
+kg NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+uterus NOUN B-O
+was AUX B-O
+exposed VERB B-O
+. PUNCT B-O
+
+All DET B-O
+patients NOUN B-O
+with ADP B-O
+IVF PROPN B-AC
+received VERB B-O
+an DET B-O
+implantable ADJ B-LF
+cardioverter ADJ I-LF
+defibrillator NOUN I-LF
+( PUNCT B-O
+ICD PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Patients NOUN B-O
+took VERB B-O
+oral ADJ B-O
+antiarrhythmic ADJ B-O
+agents NOUN B-O
+during ADP B-O
+the DET B-O
+follow NOUN B-O
+- ADJ B-O
+up ADP B-O
+period NOUN B-O
+, PUNCT B-O
+including VERB B-O
+amiodarone NOUN B-O
+, PUNCT B-O
+flecainide NOUN B-O
+, PUNCT B-O
+propafenone NOUN B-O
+, PUNCT B-O
+beta NOUN B-O
+- ADJ B-O
+blockers NOUN B-O
+( PUNCT B-O
+BB PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+calcium NOUN B-O
+channel NOUN B-O
+blocker NOUN B-O
+( PUNCT B-O
+CCB PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Many ADJ B-O
+patients NOUN B-O
+did AUX B-O
+n’t PART B-O
+take VERB B-O
+medications NOUN B-O
+and CCONJ B-O
+the DET B-O
+patients NOUN B-O
+who PRON B-O
+had AUX B-O
+received VERB B-O
+medication NOUN B-O
+mostly ADV B-O
+took VERB B-O
+beta NOUN B-O
+- ADJ B-O
+blockers NOUN B-O
+: PUNCT B-O
+20 NUM B-O
+patients NOUN B-O
+in ADP B-O
+the DET B-O
+f PROPN B-AC
+group NOUN B-O
+[ PUNCT B-O
+no DET B-O
+medications NOUN B-O
+( PUNCT B-O
+7 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+BB PROPN B-O
+( PUNCT B-O
+5 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+CCB PROPN B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+amiodarone NOUN B-O
+( PUNCT B-O
+1 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+CCB PROPN B-O
++ CCONJ B-O
+BB PROPN B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+amiodarone NOUN B-O
++ CCONJ B-O
+BB PROPN B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+flecanide NOUN B-O
++ CCONJ B-O
+BB PROPN B-O
+( PUNCT B-O
+1 NUM B-O
+) PUNCT B-O
+] PUNCT B-O
+, PUNCT B-O
+35 NUM B-O
+patients NOUN B-O
+in ADP B-O
+the DET B-O
+J PROPN B-O
+wave PROPN B-O
+group NOUN B-O
+[ PUNCT B-O
+no DET B-O
+medications NOUN B-O
+( PUNCT B-O
+15 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+BB PROPN B-O
+( PUNCT B-O
+13 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+CCB PROPN B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+amiodarone NOUN B-O
+( PUNCT B-O
+2 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+CCB PROPN B-O
++ CCONJ B-O
+BB PROPN B-O
+( PUNCT B-O
+1 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+propafenone NOUN B-O
+( PUNCT B-O
+1 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+propafenone NOUN B-O
++ CCONJ B-O
+BB PROPN B-O
+( PUNCT B-O
+1 NUM B-O
+) PUNCT B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+26 NUM B-O
+patients NOUN B-O
+in ADP B-O
+the DET B-O
+normal ADJ B-O
+-QRSECG PROPN B-AC
+group NOUN B-O
+[ PUNCT B-O
+no DET B-O
+medications NOUN B-O
+( PUNCT B-O
+16 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+BB PROPN B-O
+( PUNCT B-O
+9 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+amiodarone NOUN B-O
+( PUNCT B-O
+1 NUM B-O
+) PUNCT B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Although SCONJ B-O
+adjuvant ADJ B-LF
+platinum NOUN I-LF
+- ADJ I-LF
+based VERB I-LF
+chemotherapy NOUN I-LF
+( PUNCT B-O
+AC PROPN B-AC
+) PUNCT B-O
+has AUX B-O
+been AUX B-O
+shown VERB B-O
+to PART B-O
+improve VERB B-O
+survival NOUN B-O
+of ADP B-O
+patients NOUN B-O
+with ADP B-O
+completely ADV B-O
+resected VERB B-O
+stage NOUN B-O
+II NUM B-O
+and CCONJ B-O
+stage NOUN B-O
+IIIA NUM B-O
+non ADJ B-LF
+- ADJ I-LF
+small ADJ I-LF
+cell NOUN I-LF
+lung NOUN I-LF
+cancer NOUN I-LF
+( PUNCT B-O
+NSCLC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+its PRON B-O
+effect NOUN B-O
+is AUX B-O
+limited ADJ B-O
+. PUNCT B-O
+
+The DET B-O
+DSX PROPN B-O
+transgenic ADJ B-O
+line NOUN B-O
+[ X B-O
+12 X B-O
+] X B-O
+that PRON B-O
+expresses VERB B-O
+GFP PROPN B-AC
+( PUNCT B-O
+green NOUN B-O
+) PUNCT B-O
+under ADP B-O
+the DET B-O
+β PUNCT B-O
+- NOUN B-O
+tubulin NOUN B-O
+promoter NOUN B-O
+in ADP B-O
+the DET B-O
+meiotic ADJ B-O
+stages NOUN B-O
+starting VERB B-O
+from ADP B-O
+spermatocytes NOUN B-O
+but CCONJ B-O
+not PART B-O
+in ADP B-O
+the DET B-O
+mitotic ADJ B-O
+germline NOUN B-LF
+stem NOUN I-LF
+cells NOUN I-LF
+( PUNCT B-O
+GSC PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+spermatogonia NOUN B-O
+. PUNCT B-O
+
+MS PROPN B-AC
+, PUNCT B-O
+multiple ADJ B-LF
+sclerosis NOUN I-LF
+; PUNCT B-O
+PMD PROPN B-AC
+, PUNCT B-O
+postmortem ADJ B-LF
+delay NOUN I-LF
+. PUNCT B-O
+
+A DET B-O
+common ADJ B-O
+limitation NOUN B-O
+of ADP B-O
+SE PROPN B-AC
+recording NOUN B-O
+is AUX B-O
+the DET B-O
+lack NOUN B-O
+of ADP B-O
+true ADJ B-O
+monophasic ADJ B-O
+shapes NOUN B-O
+of ADP B-O
+recorded VERB B-O
+CAPs PROPN B-AC
+due ADJ B-O
+to ADP B-O
+propagation NOUN B-O
+of ADP B-O
+action NOUN B-O
+potentials NOUN B-O
+within ADP B-O
+the DET B-O
+SE PROPN B-AC
+portion NOUN B-O
+of ADP B-O
+axons NOUN B-O
+, PUNCT B-O
+resulting VERB B-O
+in ADP B-O
+different ADJ B-O
+degrees NOUN B-O
+of ADP B-O
+biphasicity NOUN B-O
+depending VERB B-O
+on ADP B-O
+preservation NOUN B-O
+of ADP B-O
+conduction NOUN B-O
+properties NOUN B-O
+of ADP B-O
+distinct ADJ B-O
+types NOUN B-O
+of ADP B-O
+axons NOUN B-O
+within ADP B-O
+the DET B-O
+SE PROPN B-AC
+. PUNCT B-O
+
+As ADP B-O
+in ADP B-O
+any DET B-O
+SE PROPN B-AC
+- PUNCT B-O
+recorded VERB B-O
+CAPs PROPN B-AC
+, PUNCT B-O
+the DET B-O
+signals NOUN B-O
+propagating VERB B-O
+within ADP B-O
+the DET B-O
+suction NOUN B-LF
+electrode NOUN I-LF
+portion NOUN B-O
+of ADP B-O
+axons NOUN B-O
+may AUX B-O
+create VERB B-O
+a DET B-O
+time NOUN B-O
+- PUNCT B-O
+shifted VERB B-O
+signal NOUN B-O
+of ADP B-O
+opposite ADJ B-O
+polarity NOUN B-O
+affecting VERB B-O
+the DET B-O
+peaks NOUN B-O
+and CCONJ B-O
+valleys NOUN B-O
+of ADP B-O
+recorded VERB B-O
+signals NOUN B-O
+, PUNCT B-O
+being AUX B-O
+more ADV B-O
+pronounced ADJ B-O
+in ADP B-O
+slower ADV B-O
+conducting VERB B-O
+components NOUN B-O
+( PUNCT B-O
+seen VERB B-O
+to ADP B-O
+different ADJ B-O
+extent NOUN B-O
+in ADP B-O
+Figs NOUN B-O
+2–9 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Healthcare NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+infections NOUN I-LF
+( PUNCT B-O
+HAIs PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+associated VERB B-O
+with ADP B-O
+increased VERB B-O
+morbidity NOUN B-O
+and CCONJ B-O
+mortality NOUN B-O
+and CCONJ B-O
+excess ADJ B-O
+costs NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+because SCONJ B-O
+a DET B-O
+significant ADJ B-O
+proportion NOUN B-O
+of ADP B-O
+them PRON B-O
+are AUX B-O
+preventable ADJ B-O
+, PUNCT B-O
+they PRON B-O
+are AUX B-O
+considered VERB B-O
+to PART B-O
+be AUX B-O
+a DET B-O
+marker NOUN B-O
+of ADP B-O
+quality NOUN B-O
+of ADP B-O
+patient NOUN B-O
+care NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Randomised ADJ B-LF
+controlled VERB I-LF
+trials NOUN I-LF
+( PUNCT B-O
+RCTs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+longitudinal ADJ B-O
+cohort NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+cross ADJ B-O
+- ADJ B-O
+sectional ADJ B-O
+studies NOUN B-O
+were AUX B-O
+considered VERB B-O
+for ADP B-O
+inclusion NOUN B-O
+, PUNCT B-O
+whereas SCONJ B-O
+retrospective ADJ B-O
+registry NOUN B-O
+reviews NOUN B-O
+, PUNCT B-O
+medical ADJ B-O
+records NOUN B-O
+audits NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+qualitative ADJ B-O
+studies NOUN B-O
+were AUX B-O
+excluded VERB B-O
+. PUNCT B-O
+
+These DET B-O
+results NOUN B-O
+are AUX B-O
+not PART B-O
+from ADP B-O
+data NOUN B-O
+collected VERB B-O
+in ADP B-O
+a DET B-O
+centralised ADJ B-O
+laboratory NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+different ADJ B-O
+multiplex NOUN B-O
+polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT B-O
+PCR PROPN B-AC
+) PUNCT B-O
+panels NOUN B-O
+for ADP B-O
+detecting VERB B-O
+viruses NOUN B-O
+were AUX B-O
+used VERB B-O
+in ADP B-O
+the DET B-O
+respective ADJ B-O
+laboratories NOUN B-O
+[ PUNCT B-O
+19 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Open ADJ B-LF
+access NOUN I-LF
+( PUNCT B-O
+OA PROPN B-AC
+) PUNCT B-O
+to ADP B-O
+the DET B-O
+scientific ADJ B-O
+literature NOUN B-O
+means VERB B-O
+the DET B-O
+removal NOUN B-O
+of ADP B-O
+barriers NOUN B-O
+( PUNCT B-O
+including VERB B-O
+price NOUN B-O
+barriers NOUN B-O
+) PUNCT B-O
+from ADP B-O
+accessing VERB B-O
+scholarly ADJ B-O
+work NOUN B-O
+. PUNCT B-O
+
+f X B-O
+- X B-O
+forward NOUN B-O
+; PUNCT B-O
+r NOUN B-O
+- X B-O
+reverse NOUN B-O
+; PUNCT B-O
+Ta NOUN B-O
+– PUNCT B-O
+Annealing NOUN B-O
+temperature NOUN B-O
+, PUNCT B-O
+RE- NOUN B-O
+restriction NOUN B-O
+Enzyme PROPN B-O
+, PUNCT B-O
+AS PROPN B-AC
+- X B-O
+Allele PROPN B-LF
+Specific PROPN I-LF
+Ref PROPN B-O
+- X B-O
+reference NOUN B-O
+We PRON B-O
+also ADV B-O
+collected VERB B-O
+measures NOUN B-O
+of ADP B-O
+inhibitory ADJ B-O
+control NOUN B-O
+and CCONJ B-O
+working VERB B-O
+memory NOUN B-O
+using VERB B-O
+the DET B-O
+pencil NOUN B-LF
+tapping NOUN I-LF
+task NOUN I-LF
+( PUNCT B-O
+PTT PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+29 X B-O
+] PUNCT B-O
+and CCONJ B-O
+of ADP B-O
+pre ADJ B-O
+- PUNCT B-O
+academic ADJ B-O
+skills NOUN B-O
+using VERB B-O
+a DET B-O
+subset NOUN B-O
+of ADP B-O
+age NOUN B-O
+- PUNCT B-O
+appropriate ADJ B-O
+items NOUN B-O
+from ADP B-O
+the DET B-O
+Daberon PROPN B-LF
+Screening PROPN I-LF
+for ADP I-LF
+School PROPN I-LF
+Readiness PROPN I-LF
+– PUNCT I-LF
+Second PROPN I-LF
+Edition PROPN I-LF
+( PUNCT B-O
+Daberon-2 PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+30 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Acute ADJ B-LF
+respiratory ADJ I-LF
+infection NOUN I-LF
+( PUNCT B-O
+ARI PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+diarrhoea NOUN B-O
+are AUX B-O
+the DET B-O
+leading VERB B-O
+causes NOUN B-O
+of ADP B-O
+childhood NOUN B-O
+morbidity NOUN B-O
+and CCONJ B-O
+mortality NOUN B-O
+in ADP B-O
+Ethiopia PROPN B-O
+. PUNCT B-O
+
+Clinical ADJ B-O
+outcomes NOUN B-O
+and CCONJ B-O
+the DET B-O
+proportion NOUN B-O
+of ADP B-O
+justified ADJ B-O
+use NOUN B-O
+of ADP B-O
+personal ADJ B-O
+nursing NOUN B-O
+care NOUN B-O
+were AUX B-O
+evaluated VERB B-O
+using VERB B-O
+a DET B-O
+statistical ADJ B-O
+technique NOUN B-O
+known VERB B-O
+as ADP B-O
+Generalized PROPN B-LF
+Pairwise PROPN I-LF
+Comparisons PROPN I-LF
+( PUNCT B-O
+GPC PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+46 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Within ADP B-O
+the DET B-O
+control NOUN B-O
+group NOUN B-O
+CRMP-5 PROPN B-AC
+was AUX B-O
+verified VERB B-O
+with ADP B-O
+a DET B-O
+label NOUN B-LF
+- PUNCT I-LF
+free ADJ I-LF
+quantification NOUN I-LF
+intensity NOUN I-LF
+( PUNCT B-O
+LFQI PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+1.93x109 NUM B-O
+. PUNCT B-O
+
+Notably ADV B-O
+, PUNCT B-O
+although SCONJ B-O
+it PRON B-O
+has AUX B-O
+previously ADV B-O
+been AUX B-O
+hypothesized VERB B-O
+that SCONJ B-O
+the DET B-O
+hormonal ADJ B-O
+drivers NOUN B-O
+of ADP B-O
+PD PROPN B-AC
+would AUX B-O
+result VERB B-O
+in ADP B-O
+it PRON B-O
+being AUX B-O
+a DET B-O
+stronger ADJ B-O
+risk NOUN B-O
+marker NOUN B-O
+for ADP B-O
+oestrogen NOUN B-LF
+receptor NOUN I-LF
+( PUNCT B-O
+ER)–positive PROPN B-AC
+than ADP B-O
+ER PROPN B-AC
+- PUNCT B-O
+negative ADJ B-O
+breast NOUN B-O
+cancer NOUN B-O
+, PUNCT B-O
+a DET B-O
+large ADJ B-O
+differential NOUN B-O
+in ADP B-O
+the DET B-O
+MD PROPN B-AC
+- PUNCT B-O
+breast NOUN B-O
+cancer NOUN B-O
+association NOUN B-O
+by ADP B-O
+tumour NOUN B-O
+subtype NOUN B-O
+does AUX B-O
+not PART B-O
+appear VERB B-O
+to PART B-O
+be AUX B-O
+present ADJ B-O
+[ PUNCT B-O
+23 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Interleukins NOUN B-LF
+( PUNCT B-O
+ILs PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+a DET B-O
+group NOUN B-O
+of ADP B-O
+cytokines NOUN B-O
+that PRON B-O
+are AUX B-O
+involved VERB B-O
+in ADP B-O
+the DET B-O
+communication NOUN B-O
+between ADP B-O
+immune ADJ B-O
+and CCONJ B-O
+inflammatory ADJ B-O
+cells NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+38 NUM B-O
+ILs PROPN B-AC
+have AUX B-O
+been AUX B-O
+identified VERB B-O
+thus ADV B-O
+far ADV B-O
+. PUNCT B-O
+
+There PRON B-O
+are VERB B-O
+different ADJ B-O
+types NOUN B-O
+of ADP B-O
+medication NOUN B-O
+reviews NOUN B-O
+, PUNCT B-O
+ranging VERB B-O
+from ADP B-O
+a DET B-O
+prescription NOUN B-O
+review NOUN B-O
+( PUNCT B-O
+which PRON B-O
+is AUX B-O
+basically ADV B-O
+an DET B-O
+evaluation NOUN B-O
+of ADP B-O
+the DET B-O
+list NOUN B-O
+of ADP B-O
+prescribed VERB B-O
+medicines NOUN B-O
+) PUNCT B-O
+to ADP B-O
+a DET B-O
+clinical ADJ B-LF
+medication NOUN I-LF
+review NOUN I-LF
+( PUNCT B-O
+CMR PROPN B-AC
+; PUNCT B-O
+with ADP B-O
+the DET B-O
+availability NOUN B-O
+of ADP B-O
+all DET B-O
+clinical ADJ B-O
+data NOUN B-O
+and CCONJ B-O
+an DET B-O
+extensive ADJ B-O
+patient NOUN B-O
+interview NOUN B-O
+) PUNCT B-O
+[ PUNCT B-O
+3 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Sural ADJ B-LF
+sensory ADJ I-LF
+nerve NOUN I-LF
+amplitude NOUN I-LF
+( PUNCT B-O
+SSNamp PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+sural ADJ B-LF
+sensory ADJ I-LF
+nerve NOUN I-LF
+conduction NOUN I-LF
+velocity NOUN I-LF
+( PUNCT B-O
+SSNCV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+peroneal ADJ B-LF
+motor NOUN I-LF
+nerve NOUN I-LF
+amplitude NOUN I-LF
+( PUNCT B-O
+PMNamp PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+peroneal ADJ B-LF
+motor NOUN I-LF
+nerve NOUN I-LF
+conduction NOUN I-LF
+velocity NOUN I-LF
+( PUNCT B-O
+PMNCV PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+assessed VERB B-O
+using VERB B-O
+a DET B-O
+Dantec PROPN B-O
+“ PUNCT B-O
+Keypoint PROPN B-O
+” PUNCT B-O
+system NOUN B-O
+( PUNCT B-O
+Dantec PROPN B-O
+Dynamics PROPN B-O
+Ltd PROPN B-O
+, PUNCT B-O
+Bristol PROPN B-O
+, PUNCT B-O
+UK PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+DF PROPN B-AC
+, PUNCT B-O
+dorsal ADJ B-LF
+funiculus NOUN I-LF
+; PUNCT B-O
+dVL PROPN B-AC
+, PUNCT B-O
+dorsal ADJ B-LF
+ventricular ADJ I-LF
+layer NOUN I-LF
+; PUNCT B-O
+NKX6.1 NOUN B-O
+, PUNCT B-O
+NK6 NOUN B-O
+homeobox NOUN B-O
+1 NUM B-O
+; PUNCT B-O
+SOX2 PROPN B-O
+, PUNCT B-O
+SRY NOUN B-O
+- PUNCT B-O
+related VERB B-O
+HMG NOUN B-O
+- PUNCT B-O
+box NOUN B-O
+2 NUM B-O
+; PUNCT B-O
+VF PROPN B-AC
+, PUNCT B-O
+ventral ADJ B-LF
+funiculus NOUN I-LF
+; PUNCT B-O
+VL PROPN B-AC
+, PUNCT B-O
+ventricular ADJ B-LF
+layer NOUN I-LF
+; PUNCT B-O
+vVL PROPN B-AC
+, PUNCT B-O
+ventral ADJ B-LF
+ventricular ADJ B-LF
+layer NOUN I-LF
+; PUNCT B-O
+( PUNCT B-O
++ PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+expressing NOUN B-O
+. PUNCT B-O
+
+Powers PROPN B-O
+et PROPN B-O
+al NOUN B-O
+. PUNCT B-O
+
+estimated VERB B-O
+that SCONJ B-O
+the DET B-O
+fraction NOUN B-LF
+of ADP I-LF
+HIV PROPN I-LF
+incidence NOUN I-LF
+attributable ADJ I-LF
+to PART I-LF
+transmission NOUN I-LF
+from ADP I-LF
+acutely ADV I-LF
+infected VERB I-LF
+individuals NOUN I-LF
+( PUNCT B-O
+AFacute PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+40 NUM B-O
+% NOUN B-O
+[ PUNCT B-O
+19 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+while SCONJ B-O
+Williams PROPN B-O
+et PROPN B-O
+al NOUN B-O
+. PUNCT B-O
+
+argued VERB B-O
+that SCONJ B-O
+AFacute PROPN B-AC
+was AUX B-O
+more ADV B-O
+likely ADJ B-O
+to PART B-O
+be AUX B-O
+2%–4 NUM B-O
+% NOUN B-O
+[ PUNCT B-O
+44 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Is AUX B-O
+six NUM B-LF
+- PUNCT I-LF
+minute NOUN I-LF
+- PUNCT I-LF
+walk NOUN I-LF
+distance NOUN I-LF
+" PUNCT B-O
+6MWD PROPN B-AC
+” PUNCT B-O
+? PUNCT B-O
+Is AUX B-O
+six NUM B-LF
+- PUNCT I-LF
+minute NOUN I-LF
+- PUNCT I-LF
+walk NOUN I-LF
+test NOUN I-LF
+" PUNCT B-O
+6MWT PROPN B-AC
+” PUNCT B-O
+? PUNCT B-O
+（ PUNCT B-O
+Line NOUN B-O
+55 NUM B-O
+） PUNCT B-O
+Response NOUN B-O
+: PUNCT B-O
+We PRON B-O
+have AUX B-O
+revised VERB B-O
+the DET B-O
+abbreviations NOUN B-O
+in ADP B-O
+the DET B-O
+manuscript NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+primary ADJ B-O
+trial NOUN B-O
+outcome NOUN B-O
+was AUX B-O
+a DET B-O
+composite ADJ B-O
+endpoint NOUN B-O
+of ADP B-O
+women NOUN B-O
+’s PART B-O
+retention NOUN B-O
+in ADP B-O
+ART PROPN B-AC
+care NOUN B-O
+and CCONJ B-O
+viral ADJ B-LF
+suppression NOUN I-LF
+( PUNCT B-O
+VS PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+viral ADJ B-O
+load NOUN B-O
+< ADP B-O
+50 NUM B-O
+copies NOUN B-O
+/ SYM B-O
+ml NOUN B-O
+) PUNCT B-O
+at ADP B-O
+12 NUM B-O
+months NOUN B-O
+postpartum ADV B-O
+; PUNCT B-O
+secondary ADJ B-O
+outcomes NOUN B-O
+included VERB B-O
+duration NOUN B-O
+of ADP B-O
+any PRON B-O
+and CCONJ B-O
+exclusive ADJ B-O
+breastfeeding NOUN B-O
+, PUNCT B-O
+mother NOUN B-O
+- PUNCT B-O
+to ADP B-O
+- PUNCT B-O
+child NOUN B-O
+HIV PROPN B-O
+transmission NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+infant NOUN B-O
+mortality NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+MSIS-29 PROPN B-AC
+consists VERB B-O
+of ADP B-O
+29 NUM B-O
+questions NOUN B-O
+answered VERB B-O
+on ADP B-O
+a DET B-O
+5 NUM B-O
+- PUNCT B-O
+point NOUN B-O
+Likert PROPN B-O
+scale NOUN B-O
+, PUNCT B-O
+giving VERB B-O
+2 NUM B-O
+scores NOUN B-O
+: PUNCT B-O
+the DET B-O
+MSIS-29 PROPN B-LF
+physical ADJ I-LF
+MSIS-29 PROPN B-AC
+( PUNCT B-O
+MSIS-29 PROPN B-AC
+) PUNCT B-O
+score NOUN B-O
+( PUNCT B-O
+questions NOUN B-O
+1–20 NUM B-O
+; PUNCT B-O
+therefore ADV B-O
+score NOUN B-O
+range NOUN B-O
+20–100 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+the DET B-O
+MSIS-29 PROPN B-LF
+psychological ADJ I-LF
+-PHYSMSIS-29 PROPN B-AC
+( PUNCT B-O
+MSIS-29 PROPN B-AC
+) PUNCT B-O
+score NOUN B-O
+( PUNCT B-O
+questions NOUN B-O
+21–29 NUM B-O
+; PUNCT B-O
+therefore ADV B-O
+score NOUN B-O
+range NOUN B-O
+9–45 NUM B-O
+) PUNCT B-O
+[ PUNCT B-O
+14,26 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Metabolic ADJ B-LF
+syndrome NOUN I-LF
+( PUNCT B-O
+MetS PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+cluster NOUN B-O
+of ADP B-O
+risk NOUN B-O
+factors NOUN B-O
+that PRON B-O
+encompasses VERB B-O
+metabolic ADJ B-O
+, PUNCT B-O
+vascular ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+inflammatory ADJ B-O
+indicators NOUN B-O
+. PUNCT B-O
+
+Portal ADJ B-LF
+Venous ADJ I-LF
+Thrombosis NOUN I-LF
+( PUNCT B-O
+PVT PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+common ADJ B-O
+complication NOUN B-O
+of ADP B-O
+Hepatocellular ADJ B-LF
+Carcinoma PROPN I-LF
+( PUNCT B-O
+HCC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+assessed VERB B-O
+as ADP B-O
+adverse ADJ B-O
+prognostic ADJ B-O
+factor NOUN B-O
+and CCONJ B-O
+parameter NOUN B-O
+of ADP B-O
+tumor NOUN B-O
+aggressiveness NOUN B-O
+together ADV B-O
+with ADP B-O
+tumor NOUN B-O
+size NOUN B-O
+, PUNCT B-O
+multifocality NOUN B-O
+and CCONJ B-O
+Alpha NOUN B-LF
+- PUNCT I-LF
+fetoprotein NOUN I-LF
+( PUNCT B-O
+AFP PROPN B-AC
+) PUNCT B-O
+levels NOUN B-O
+[ PUNCT B-O
+1,2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+These DET B-O
+estimates NOUN B-O
+do AUX B-O
+not PART B-O
+account VERB B-O
+for ADP B-O
+immunity NOUN B-O
+resulting VERB B-O
+from ADP B-O
+transmission NOUN B-O
+of ADP B-O
+OPV PROPN B-AC
+among ADP B-O
+contacts NOUN B-O
+of ADP B-O
+vaccinated VERB B-O
+children NOUN B-O
+, PUNCT B-O
+maternally ADV B-O
+derived VERB B-O
+antibodies NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+naturally ADV B-O
+acquired VERB B-O
+immunity NOUN B-O
+following VERB B-O
+exposure NOUN B-O
+to ADP B-O
+cVDPV2 PROPN B-AC
+. PUNCT B-O
+
+In ADP B-O
+Nigeria PROPN B-O
+, PUNCT B-O
+receipt NOUN B-O
+of ADP B-O
+tOPV PROPN B-AC
+through ADP B-O
+RI PROPN B-AC
+was AUX B-O
+inferred VERB B-O
+from ADP B-O
+district NOUN B-O
+- PUNCT B-O
+level NOUN B-O
+coverage NOUN B-O
+with ADP B-O
+three NUM B-O
+doses NOUN B-O
+of ADP B-O
+diphtheria NOUN B-O
+- PUNCT B-O
+tetanus NOUN B-O
+- PUNCT B-O
+pertussis NOUN B-O
+( PUNCT B-O
+DTP3 PROPN B-O
+) PUNCT B-O
+vaccine NOUN B-O
+at ADP B-O
+the DET B-O
+age NOUN B-O
+of ADP B-O
+12 NUM B-O
+mo NOUN B-O
+or CCONJ B-O
+later ADV B-O
+estimated VERB B-O
+from ADP B-O
+Demographic PROPN B-LF
+and CCONJ I-LF
+Health PROPN I-LF
+Surveys PROPN I-LF
+( PUNCT B-O
+DHS PROPN B-AC
+) PUNCT B-O
+data NOUN B-O
+( PUNCT B-O
+estimates NOUN B-O
+are AUX B-O
+derived VERB B-O
+in ADP B-O
+[ PUNCT B-O
+22 NUM B-O
+] PUNCT B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Coxsackievirus PROPN B-LF
+B PROPN I-LF
+( PUNCT B-O
+CVB PROPN B-AC
+) PUNCT B-O
+belongs VERB B-O
+to ADP B-O
+the DET B-O
+Enterovirus NOUN B-O
+B PROPN B-O
+species NOUN B-O
+of ADP B-O
+the DET B-O
+Picornaviridae PROPN B-O
+family NOUN B-O
+and CCONJ B-O
+has AUX B-O
+been AUX B-O
+associated VERB B-O
+with ADP B-O
+a DET B-O
+wide ADJ B-O
+range NOUN B-O
+of ADP B-O
+diseases NOUN B-O
+from ADP B-O
+mild ADJ B-O
+respiratory ADJ B-O
+infections NOUN B-O
+to ADP B-O
+more ADV B-O
+severe ADJ B-O
+infections NOUN B-O
+of ADP B-O
+the DET B-O
+central ADJ B-O
+nervous ADJ B-O
+system NOUN B-O
+, PUNCT B-O
+heart NOUN B-O
+and CCONJ B-O
+pancreas NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+order NOUN B-O
+to PART B-O
+systematically ADV B-O
+investigate VERB B-O
+the DET B-O
+influence NOUN B-O
+of ADP B-O
+potentially ADV B-O
+functional ADJ B-O
+coding VERB B-O
+polymorphisms NOUN B-O
+in ADP B-O
+the DET B-O
+NLR PROPN B-O
+genes NOUN B-O
+on ADP B-O
+sporadic ADJ B-O
+CRC PROPN B-AC
+risk NOUN B-O
+and CCONJ B-O
+survival NOUN B-O
+, PUNCT B-O
+we PRON B-O
+conducted VERB B-O
+a DET B-O
+case NOUN B-O
+- ADJ B-O
+control NOUN B-O
+study NOUN B-O
+with ADP B-O
+replications NOUN B-O
+in ADP B-O
+2 NUM B-O
+large ADJ B-O
+genome NOUN B-O
+- ADJ B-O
+wide ADJ B-O
+association NOUN B-O
+studies NOUN B-O
+( PUNCT B-O
+GWASs PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+covering VERB B-O
+the DET B-O
+majority NOUN B-O
+of ADP B-O
+known VERB B-O
+non ADJ B-LF
+- ADJ I-LF
+synonymous ADJ I-LF
+single ADJ I-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT B-O
+nsSNPs PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+21 NUM B-O
+genes NOUN B-O
+across ADP B-O
+different ADJ B-O
+NLR PROPN B-O
+signalling NOUN B-O
+pathways NOUN B-O
+. PUNCT B-O
+
+Progress NOUN B-LF
+variables NOUN I-LF
+( PUNCT B-O
+PVs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+akin ADJ B-O
+to ADP B-O
+reaction NOUN B-O
+coordinates NOUN B-O
+, PUNCT B-O
+for ADP B-O
+all DET B-O
+free ADJ B-O
+- PUNCT B-O
+energy NOUN B-O
+molecular ADJ B-O
+dynamics NOUN B-O
+calculations NOUN B-O
+were AUX B-O
+chosen VERB B-O
+as ADP B-O
+the DET B-O
+location NOUN B-O
+on ADP B-O
+the DET B-O
+z NOUN B-O
+axis NOUN B-O
+of ADP B-O
+the DET B-O
+center NOUN B-O
+of ADP B-O
+mass NOUN B-O
+of ADP B-O
+the DET B-O
+small ADJ B-O
+- PUNCT B-O
+molecule(s NOUN B-O
+) PUNCT B-O
+of ADP B-O
+interest NOUN B-O
+. PUNCT B-O
+
+Non ADJ B-LF
+- ADJ I-LF
+alcoholic ADJ I-LF
+fatty ADJ I-LF
+liver NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+NAFLD PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+defined VERB B-O
+as ADP B-O
+the DET B-O
+accumulation NOUN B-O
+of ADP B-O
+excess ADJ B-O
+, PUNCT B-O
+microscopically ADV B-O
+visible ADJ B-O
+lipid NOUN B-O
+in ADP B-O
+hepatocytes NOUN B-O
+in ADP B-O
+the DET B-O
+absence NOUN B-O
+of ADP B-O
+excessive ADJ B-O
+alcohol NOUN B-O
+consumption NOUN B-O
+and CCONJ B-O
+is AUX B-O
+now ADV B-O
+the DET B-O
+most ADV B-O
+common ADJ B-O
+chronic ADJ B-O
+liver NOUN B-O
+disease NOUN B-O
+in ADP B-O
+developed VERB B-O
+countries NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+, PUNCT B-O
+2 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+current ADJ B-O
+prequalified ADJ B-O
+oral ADJ B-LF
+cholera NOUN I-LF
+vaccines NOUN I-LF
+( PUNCT B-O
+OCVs PROPN B-AC
+) PUNCT B-O
+provide VERB B-O
+over ADP B-O
+80 NUM B-O
+% NOUN B-O
+( PUNCT B-O
+direct ADJ B-O
+) PUNCT B-O
+protection NOUN B-O
+in ADP B-O
+the DET B-O
+first ADJ B-O
+6 NUM B-O
+mo NOUN B-O
+after ADP B-O
+vaccination NOUN B-O
+[ PUNCT B-O
+2–4 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+protection NOUN B-O
+of ADP B-O
+up ADP B-O
+to PART B-O
+65 NUM B-O
+% NOUN B-O
+for ADP B-O
+5 NUM B-O
+y NOUN B-O
+estimated VERB B-O
+in ADP B-O
+an DET B-O
+endemic ADJ B-O
+setting NOUN B-O
+[ PUNCT B-O
+5 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+volatile ADJ B-LF
+fatty ADJ I-LF
+acids NOUN I-LF
+( PUNCT B-O
+VFAs PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+HARs PROPN B-AC
+and CCONJ B-O
+BRs PROPN B-AC
+were AUX B-O
+measured VERB B-O
+acetic ADJ B-O
+, PUNCT B-O
+propionate NOUN B-O
+, PUNCT B-O
+iso ADJ B-O
+- PUNCT B-O
+butyric ADJ B-O
+, PUNCT B-O
+butyric ADJ B-O
+, PUNCT B-O
+valeric ADJ B-O
+and CCONJ B-O
+iso ADJ B-O
+- PUNCT B-O
+valeric ADJ B-O
+acid NOUN B-O
+by ADP B-O
+GC PROPN B-O
+( PUNCT B-O
+GC-2001 PROPN B-O
+, PUNCT B-O
+Shimadzu PROPN B-O
+, PUNCT B-O
+Japan PROPN B-O
+) PUNCT B-O
+equipped VERB B-O
+with ADP B-O
+hydrogen NOUN B-O
+flame NOUN B-O
+ionization NOUN B-O
+detector NOUN B-O
+( PUNCT B-O
+FID PROPN B-O
+) PUNCT B-O
+using VERB B-O
+Nitrogen PROPN B-O
+as ADP B-O
+a DET B-O
+carrier NOUN B-O
+gas NOUN B-O
+in ADP B-O
+a DET B-O
+quartz NOUN B-O
+capillary NOUN B-O
+column NOUN B-O
+( PUNCT B-O
+30 NUM B-O
+m×0.32 NUM B-O
+mm×D×0.25 NUM B-O
+μm NOUN B-O
+; PUNCT B-O
+Stabilwax PROPN B-O
+- PUNCT B-O
+DA PROPN B-O
+, PUNCT B-O
+RESTEK PROPN B-O
+, PUNCT B-O
+USA PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+GC PROPN B-O
+was AUX B-O
+operated VERB B-O
+when SCONJ B-O
+the DET B-O
+injection NOUN B-O
+port NOUN B-O
+and CCONJ B-O
+detector NOUN B-O
+temperatures NOUN B-O
+were AUX B-O
+220 NUM B-O
+° NUM B-O
+C NOUN B-O
+and CCONJ B-O
+230 NUM B-O
+° NUM B-O
+C NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+. PUNCT B-O
+
+Concurrently ADV B-O
+, PUNCT B-O
+Ca2 NOUN B-O
++ NOUN B-O
+binding VERB B-O
+to ADP B-O
+another DET B-O
+synaptic ADJ B-O
+vesicle NOUN B-O
+associated VERB B-O
+protein NOUN B-O
+, PUNCT B-O
+Synaptotagmin PROPN B-LF
+1 NUM I-LF
+( PUNCT B-O
+Syt1 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+triggers VERB B-O
+the DET B-O
+migration NOUN B-O
+of ADP B-O
+synaptic ADJ B-O
+vesicles NOUN B-O
+towards ADP B-O
+the DET B-O
+plasma NOUN B-O
+membrane NOUN B-O
+, PUNCT B-O
+with ADP B-O
+Syt1 PROPN B-AC
+mediating VERB B-O
+the DET B-O
+docking NOUN B-O
+, PUNCT B-O
+fusion NOUN B-O
+and CCONJ B-O
+exocytosis NOUN B-O
+of ADP B-O
+the DET B-O
+readily ADV B-O
+releasable ADJ B-O
+synaptic ADJ B-O
+vesicles NOUN B-O
+at ADP B-O
+the DET B-O
+synaptic ADJ B-O
+cleft NOUN B-O
+[ PUNCT B-O
+30–32 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Light NOUN B-O
+induced VERB B-O
+c NOUN B-O
+- PUNCT B-O
+Fos NOUN B-O
+immunoreactivity NOUN B-O
+in ADP B-O
+the DET B-O
+suprachiasmatic ADJ B-O
+nuclei NOUN B-O
+( PUNCT B-O
+SCN PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+in ADP B-O
+sleep NOUN B-O
+- PUNCT B-O
+active ADJ B-O
+ventrolateral ADJ B-LF
+preoptic ADJ I-LF
+( PUNCT B-O
+VLPO PROPN B-AC
+) PUNCT B-O
+neurons NOUN B-O
+was AUX B-O
+importantly ADV B-O
+reduced VERB B-O
+in ADP B-O
+Opn4−/− PROPN B-O
+mice NOUN B-O
+, PUNCT B-O
+implicating VERB B-O
+both DET B-O
+sleep NOUN B-O
+- PUNCT B-O
+regulatory ADJ B-O
+structures NOUN B-O
+in ADP B-O
+the DET B-O
+melanopsin NOUN B-O
+- PUNCT B-O
+mediated VERB B-O
+effects NOUN B-O
+of ADP B-O
+light NOUN B-O
+. PUNCT B-O
+
+SDS PROPN B-O
+- ADJ B-O
+PAGE PROPN B-O
+under ADP B-O
+reducing VERB B-O
+conditions NOUN B-O
+of ADP B-O
+antithrombin ADJ B-O
+in ADP B-O
+complex NOUN B-O
+with ADP B-O
+FXa PROPN B-O
+upon SCONJ B-O
+activation NOUN B-O
+with ADP B-O
+low ADJ B-LF
+molecular ADJ I-LF
+weight NOUN I-LF
+heparin NOUN I-LF
+( PUNCT B-O
+LMWH PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+active ADJ B-O
+heparanase NOUN B-O
+( PUNCT B-O
+HPSE PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+10 NUM B-O
+- ADJ B-O
+fold ADJ B-O
+concentrated ADJ B-O
+medium NOUN B-O
+of ADP B-O
+cells NOUN B-O
+transfected VERB B-O
+with ADP B-O
+proheparanase NOUN B-O
+( PUNCT B-O
+mProHPSE PROPN B-O
+) PUNCT B-O
+; PUNCT B-O
+10 NUM B-O
+- ADJ B-O
+fold ADJ B-O
+concentrated ADJ B-O
+medium NOUN B-O
+of ADP B-O
+cells NOUN B-O
+transfected VERB B-O
+with ADP B-O
+an DET B-O
+empty ADJ B-O
+plasmid NOUN B-O
+but CCONJ B-O
+supplemented VERB B-O
+with ADP B-O
+active ADJ B-O
+heparanase NOUN B-O
+( PUNCT B-O
+mHPSE PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Detection NOUN B-O
+was AUX B-O
+done VERB B-O
+by ADP B-O
+western ADJ B-O
+blot NOUN B-O
+using VERB B-O
+an DET B-O
+anti ADJ B-O
+- ADJ B-O
+antithrombin ADJ B-O
+antibody NOUN B-O
+. PUNCT B-O
+
+Treating VERB B-O
+hyperglycemia NOUN B-O
+in ADP B-O
+previously ADV B-O
+non ADJ B-O
+- PUNCT B-O
+diabetic ADJ B-O
+individuals NOUN B-O
+with ADP B-O
+exogenous ADJ B-O
+insulin NOUN B-O
+immediately ADV B-O
+after ADP B-O
+kidney NOUN B-O
+transplantation NOUN B-O
+reduced VERB B-O
+the DET B-O
+odds NOUN B-O
+of ADP B-O
+developing VERB B-O
+Posttransplantation PROPN B-LF
+Diabetes PROPN I-LF
+Mellitus PROPN I-LF
+( PUNCT B-O
+PTDM PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+our PRON B-O
+previous ADJ B-O
+proof NOUN B-O
+- PUNCT B-O
+of ADP B-O
+- PUNCT B-O
+concept NOUN B-O
+clinical ADJ B-O
+trial NOUN B-O
+. PUNCT B-O
+
+Our PRON B-O
+dataset NOUN B-O
+comprised VERB B-O
+40 NUM B-O
+acylcarnitines NOUN B-O
+, PUNCT B-O
+34 NUM B-O
+lipids NOUN B-O
+( PUNCT B-O
+14 NUM B-O
+lysophospholipids NOUN B-O
+, PUNCT B-O
+10 NUM B-O
+sphingolipids NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+10 NUM B-O
+phosphatidylcholines NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+24 NUM B-O
+amino ADJ B-O
+acids NOUN B-O
+, PUNCT B-O
+16 NUM B-O
+organic ADJ B-O
+acids NOUN B-O
+, PUNCT B-O
+12 NUM B-O
+biogenic ADJ B-O
+amines NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+4 NUM B-O
+metabolites NOUN B-O
+classified VERB B-O
+as ADP B-O
+‘ PUNCT B-O
+other ADJ B-O
+’ PUNCT B-O
+( PUNCT B-O
+creatine NOUN B-O
+, PUNCT B-O
+choline NOUN B-O
+, PUNCT B-O
+trimethylamine NOUN B-LF
+N NOUN I-LF
+- PUNCT I-LF
+oxide NOUN I-LF
+[ PUNCT B-O
+TMAO PROPN B-AC
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+glucose NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Brazil PROPN B-O
+’s PART B-O
+considerable ADJ B-O
+investments NOUN B-O
+in ADP B-O
+social ADJ B-O
+protection NOUN B-O
+policies NOUN B-O
+over ADP B-O
+the DET B-O
+last ADJ B-O
+two NUM B-O
+decades NOUN B-O
+include VERB B-O
+the DET B-O
+rollout NOUN B-O
+of ADP B-O
+conditional ADJ B-O
+cash NOUN B-O
+transfers NOUN B-O
+under ADP B-O
+the DET B-O
+Bolsa PROPN B-O
+Família PROPN B-O
+programme NOUN B-O
+and CCONJ B-O
+a DET B-O
+commitment NOUN B-O
+to ADP B-O
+UHC PROPN B-AC
+with ADP B-O
+the DET B-O
+expansion NOUN B-O
+of ADP B-O
+PHC PROPN B-AC
+through ADP B-O
+the DET B-O
+Estratégia PROPN B-LF
+de ADP I-LF
+Saúde PROPN I-LF
+da PROPN I-LF
+Família PROPN I-LF
+( PUNCT B-O
+ESF PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+family NOUN B-O
+health NOUN B-O
+strategy NOUN B-O
+) PUNCT B-O
+[ PUNCT B-O
+14,15 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+For ADP B-O
+comparison NOUN B-O
+to ADP B-O
+the DET B-O
+Global PROPN B-LF
+Lipids PROPN I-LF
+Genetics PROPN I-LF
+Consortium PROPN I-LF
+( PUNCT B-O
+GLGC PROPN B-AC
+) PUNCT B-O
+lipid NOUN B-O
+panel NOUN B-O
+and CCONJ B-O
+extension NOUN B-O
+to ADP B-O
+other ADJ B-O
+lipoproteins NOUN B-O
+, PUNCT B-O
+we PRON B-O
+also ADV B-O
+included VERB B-O
+the DET B-O
+2019 NUM B-O
+release NOUN B-O
+of ADP B-O
+the DET B-O
+Neale PROPN B-O
+Lab PROPN B-O
+UKB PROPN B-AC
+GWAS PROPN B-AC
+( PUNCT B-O
+automated ADJ B-O
+diastolic ADJ B-O
+and CCONJ B-O
+systolic ADJ B-O
+blood NOUN B-LF
+pressure NOUN I-LF
+( PUNCT B-O
+BP PROPN B-AC
+) PUNCT B-O
+measurement NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+their PRON B-O
+biochemistry NOUN B-O
+panel NOUN B-O
+( PUNCT B-O
+HDL PROPN B-AC
+, PUNCT B-O
+-CLDL PROPN B-AC
+direct ADJ B-O
+, PUNCT B-O
+-CTRG PROPN B-AC
+, PUNCT B-O
+apolipoprotein NOUN B-LF
+A NOUN I-LF
+( PUNCT B-O
+ApoA PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+ApoB PROPN B-AC
+, PUNCT B-O
+and CCONJ B-O
+lipoprotein NOUN B-O
+A NOUN B-O
+) PUNCT B-O
+[ PUNCT B-O
+36 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+CH PROPN B-AC
+, PUNCT B-O
+chronic ADJ B-LF
+hepatitis NOUN I-LF
+; PUNCT B-O
+LC PROPN B-AC
+, PUNCT B-O
+liver NOUN B-O
+cirrhotic ADJ B-O
+; PUNCT B-O
+HCC PROPN B-AC
+, PUNCT B-O
+hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+; PUNCT B-O
+SNP PROPN B-AC
+, PUNCT B-O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphism NOUN I-LF
+; PUNCT B-O
+HWE PROPN B-AC
+, PUNCT B-O
+Hardy PROPN B-LF
+- PUNCT I-LF
+Weinberg PROPN I-LF
+Equilibrium PROPN I-LF
+; PUNCT B-O
+Del PROPN B-O
+, PUNCT B-O
+deletion NOUN B-O
+; PUNCT B-O
+ID NOUN B-O
+, PUNCT B-O
+insertion NOUN B-O
++ SYM B-O
+deletion NOUN B-O
+; PUNCT B-O
+Ht PROPN B-AC
+, PUNCT B-O
+haplotype NOUN B-LF
+. PUNCT B-O
+
+Foam NOUN B-O
+cell NOUN B-O
+formation NOUN B-O
+is AUX B-O
+regulated VERB B-O
+by ADP B-O
+several ADJ B-O
+factors NOUN B-O
+: NOUN B-O
+1 NUM B-O
+) PUNCT B-O
+scavenger NOUN B-O
+receptors NOUN B-O
+, PUNCT B-O
+such ADJ B-O
+as ADP B-O
+CD36 PROPN B-AC
+and CCONJ B-O
+lectin NOUN B-O
+- NOUN B-O
+like ADJ B-O
+ox- NOUN B-O
+low ADJ B-LF
+- NOUN I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+( PUNCT B-O
+LDL PROPN B-AC
+) PUNCT B-O
+receptor-1 NOUN B-O
+( PUNCT B-O
+Lox-1 PROPN B-AC
+) PUNCT B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+2 X B-O
+) PUNCT B-O
+acyl NOUN B-O
+- NOUN B-O
+coenzyme NOUN B-O
+A NOUN B-O
+: NOUN B-O
+cholesterol NOUN B-O
+acyltransferase NOUN B-O
+1 NUM B-O
+( PUNCT B-O
+ACAT1 PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+rate NOUN B-O
+- NOUN B-O
+limiting VERB B-O
+enzyme NOUN B-O
+for ADP B-O
+the DET B-O
+esterification NOUN B-O
+of ADP B-O
+cholesterol NOUN B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+3 X B-O
+) PUNCT B-O
+free ADJ B-O
+- NOUN B-O
+cholesterol NOUN B-O
+efflux NOUN B-O
+mediated VERB B-O
+by ADP B-O
+ATP PROPN B-O
+- NOUN B-O
+binding VERB B-O
+cassette NOUN B-O
+transporter NOUN B-O
+A1 NOUN B-O
+( PUNCT B-O
+ABCA1 PROPN B-O
+) PUNCT B-O
+and CCONJ B-O
+ATP PROPN B-O
+- NOUN B-O
+binding VERB B-O
+cassette NOUN B-O
+sub NOUN B-O
+- NOUN B-O
+family NOUN B-O
+G NOUN B-O
+member NOUN B-O
+1 NUM B-O
+( PUNCT B-O
+ABCG1 PROPN B-O
+) PUNCT B-O
+[ PUNCT B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Events NOUN B-O
+corresponding VERB B-O
+to PART B-O
+γδ PUNCT B-O
+T NOUN B-O
+( PUNCT B-O
+green ADJ B-O
+) PUNCT B-O
+, PUNCT B-O
+invariant ADJ B-O
+natural ADJ B-O
+killer NOUN B-O
+T NOUN B-O
+( PUNCT B-O
+iNKT PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+red ADJ B-O
+) PUNCT B-O
+, PUNCT B-O
+MAIT PROPN B-AC
+( PUNCT B-O
+blue ADJ B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+conventional ADJ B-O
+T NOUN B-O
+( PUNCT B-O
+Tconv PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+cyan NOUN B-O
+) PUNCT B-O
+cells NOUN B-O
+were AUX B-O
+superimposed VERB B-O
+to PART B-O
+generate VERB B-O
+a DET B-O
+dot NOUN B-O
+plot NOUN B-O
+( PUNCT B-O
+B NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+frequency NOUN B-O
+of ADP B-O
+IFN PROPN B-AC
+- NOUN B-O
+γ+ NOUN B-O
+cells NOUN B-O
+and CCONJ B-O
+the DET B-O
+mean ADJ B-LF
+fluorescence NOUN I-LF
+intensity NOUN I-LF
+( PUNCT B-O
+MFI PROPN B-AC
+) PUNCT B-O
+of ADP B-O
+IFN PROPN B-AC
+- NOUN B-O
+γ PUNCT B-O
+staining NOUN B-O
+were AUX B-O
+determined VERB B-O
+in ADP B-O
+7 NUM B-O
+donors NOUN B-O
+, PUNCT B-O
+each PRON B-O
+of ADP B-O
+whom PRON B-O
+is AUX B-O
+represented VERB B-O
+by ADP B-O
+a DET B-O
+circle NOUN B-O
+( PUNCT B-O
+C NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Five NUM B-O
+subpopulations NOUN B-O
+were AUX B-O
+defined VERB B-O
+among ADP B-O
+SEB PROPN B-AC
+- NOUN B-O
+stimulated VERB B-O
+CD3 NOUN B-O
++ NOUN B-O
+cells NOUN B-O
+based VERB B-O
+on ADP B-O
+their PRON B-O
+co NOUN B-O
+- NOUN B-O
+expression NOUN B-O
+of ADP B-O
+CD161 NOUN B-O
+and CCONJ B-O
+Vα7.2 NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+lack NOUN B-O
+thereof ADV B-O
+. PUNCT B-O
+
+Receiver NOUN B-O
+- PUNCT B-O
+operating VERB B-O
+characteristic ADJ B-O
+( PUNCT B-O
+ROC PROPN B-AC
+) PUNCT B-O
+curves NOUN B-O
+were AUX B-O
+constructed VERB B-O
+to PART B-O
+calculate VERB B-O
+the DET B-O
+best ADJ B-O
+cutoff NOUN B-O
+values NOUN B-O
+, PUNCT B-O
+including VERB B-O
+the DET B-O
+area NOUN B-O
+under ADP B-O
+the DET B-O
+curve NOUN B-O
+( PUNCT B-O
+AUC PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT B-O
+PPV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+negative ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT B-O
+NPV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+accuracy NOUN B-O
+for ADP B-O
+discriminating VERB B-O
+H. NOUN B-O
+pylori NOUN B-O
+positivity NOUN B-O
+, PUNCT B-O
+chronic ADJ B-O
+gastritis NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+atrophic ADJ B-O
+gastritis NOUN B-O
+. PUNCT B-O
+
+To ADP B-O
+that DET B-O
+end NOUN B-O
+, PUNCT B-O
+the DET B-LF
+Cancer PROPN I-LF
+Genome PROPN I-LF
+Atlas PROPN I-LF
+( PUNCT B-O
+TCGA PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+used VERB B-O
+to PART B-O
+identify VERB B-O
+samples NOUN B-O
+from ADP B-O
+LUSC PROPN B-AC
+( PUNCT B-O
+lung ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+) PUNCT B-O
+and CCONJ B-O
+LUAC PROPN B-AC
+( PUNCT B-O
+lung ADJ B-LF
+adenocarcinoma NOUN I-LF
+) PUNCT B-O
+patients NOUN B-O
+for ADP B-O
+which PRON B-O
+clinical ADJ B-O
+follow VERB B-O
+- PUNCT B-O
+up ADP B-O
+data NOUN B-O
+was AUX B-O
+available ADJ B-O
+. PUNCT B-O
+
+STROBE PROPN B-AC
+, PUNCT B-O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting NOUN I-LF
+of ADP I-LF
+Observational ADJ I-LF
+Studies NOUN I-LF
+in ADP I-LF
+Epidemiology NOUN I-LF
+. PUNCT B-O
+
+All DET B-O
+these DET B-O
+13 NUM B-O
+genes NOUN B-O
+are AUX B-O
+co ADJ B-O
+- ADJ B-O
+DE PROPN B-AC
+in ADP B-O
+acute ADJ B-LF
+megakaryoblastic ADJ I-LF
+leukemia NOUN I-LF
+( PUNCT B-O
+AMKL PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+acute ADJ B-LF
+myeloid ADJ I-LF
+leukemia NOUN I-LF
+( PUNCT B-O
+AML PROPN B-AC
+) PUNCT B-O
+mononuclear ADJ B-O
+cells NOUN B-O
+. PUNCT B-O
+
+Gi PROPN B-AC
+, PUNCT B-O
+nucleus NOUN B-LF
+gigantocellularis NOUN I-LF
+; PUNCT B-O
+DR PROPN B-AC
+, PUNCT B-O
+dorsal ADJ B-LF
+raphé NOUN I-LF
+; PUNCT B-O
+LC PROPN B-AC
+, PUNCT B-O
+locus NOUN B-LF
+coeruleus NOUN I-LF
+; PUNCT B-O
+LDT PROPN B-AC
+, PUNCT B-O
+laterodorsal ADJ B-LF
+tegmental ADJ I-LF
+nucleus NOUN I-LF
+; PUNCT B-O
+PC PROPN B-AC
+, PUNCT B-O
+nucleus NOUN B-LF
+pontis NOUN I-LF
+caudalis NOUN I-LF
+; PUNCT B-O
+PO PROPN B-AC
+, PUNCT B-O
+nucleus NOUN B-LF
+pontis NOUN I-LF
+oralis ADJ I-LF
+; PUNCT B-O
+SubLC PROPN B-AC
+, PUNCT B-O
+subcoeruleus NOUN B-LF
+PM2.5 PROPN B-AC
+, PUNCT B-O
+particulate NOUN B-LF
+matter NOUN I-LF
+with ADP I-LF
+an DET I-LF
+aerodynamic ADJ I-LF
+diameter NOUN I-LF
+less ADJ I-LF
+than ADP I-LF
+or CCONJ I-LF
+equal ADJ I-LF
+to ADP I-LF
+2.5 NUM I-LF
+μm NOUN I-LF
+or CCONJ I-LF
+fine ADJ I-LF
+particulate NOUN I-LF
+matter NOUN I-LF
+; PUNCT B-O
+YLL PROPN B-AC
+, PUNCT B-O
+years NOUN B-LF
+of ADP I-LF
+life NOUN I-LF
+lost VERB I-LF
+. PUNCT B-O
+
+Inflammation NOUN B-O
+is AUX B-O
+an DET B-O
+important ADJ B-O
+factor NOUN B-O
+in ADP B-O
+the DET B-O
+pathogenesis NOUN B-O
+of ADP B-O
+calcific ADJ B-O
+aortic ADJ B-LF
+stenosis NOUN I-LF
+( PUNCT B-O
+AS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+We PRON B-O
+aimed VERB B-O
+to ADP B-O
+evaluate VERB B-O
+the DET B-O
+association NOUN B-O
+between ADP B-O
+an DET B-O
+inflammatory ADJ B-O
+marker NOUN B-O
+, PUNCT B-O
+neutrophil NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+lymphocyte NOUN I-LF
+ratio NOUN I-LF
+( PUNCT B-O
+NLR PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+major ADJ B-LF
+adverse ADJ I-LF
+cardiovascular ADJ I-LF
+events NOUN I-LF
+( PUNCT B-O
+MACE PROPN B-AC
+) PUNCT B-O
+in ADP B-O
+patients NOUN B-O
+with ADP B-O
+severe ADJ B-O
+calcific ADJ B-O
+AS PROPN B-AC
+. PUNCT B-O
+
+Nuclei NOUN B-O
+were AUX B-O
+stained VERB B-O
+by ADP B-O
+4',6 NUM B-LF
+- PUNCT I-LF
+diamidino-2 NOUN I-LF
+- PUNCT I-LF
+phenylindole NOUN I-LF
+( PUNCT B-O
+DAPI PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+Sigma PROPN B-O
+- PUNCT B-O
+Aldrich PROPN B-O
+, PUNCT B-O
+Lyon PROPN B-O
+, PUNCT B-O
+France PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+used VERB B-O
+at ADP B-O
+a DET B-O
+1:2000 NUM B-O
+dilution NOUN B-O
+in ADP B-O
+Mowiol PROPN B-O
+mounting NOUN B-O
+medium NOUN B-O
+( PUNCT B-O
+2.4 NUM B-O
+g NOUN B-O
+Mowiol PROPN B-O
+4–88 NUM B-O
+from ADP B-O
+Sigma PROPN B-O
+- PUNCT B-O
+Aldrich PROPN B-O
+, PUNCT B-O
+6 NUM B-O
+g NOUN B-O
+glycerol NOUN B-O
+, PUNCT B-O
+6 NUM B-O
+mL NOUN B-O
+distilled VERB B-O
+water NOUN B-O
+, PUNCT B-O
+12 NUM B-O
+mL NOUN B-O
+0.2 NUM B-O
+M NOUN B-O
+Tris NOUN B-O
+- PUNCT B-O
+Cl NOUN B-O
+buffer NOUN B-O
+· PUNCT B-O
+pH NOUN B-O
+8.5 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Here ADV B-O
+, PUNCT B-O
+we PRON B-O
+use VERB B-O
+cryo NOUN B-LF
+- PUNCT I-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT B-O
+cryoEM PROPN B-AC
+) PUNCT B-O
+to ADP B-O
+decipher VERB B-O
+the DET B-O
+mechanism NOUN B-O
+of ADP B-O
+action NOUN B-O
+of ADP B-O
+a DET B-O
+potent ADJ B-O
+HA PROPN B-AC
+head NOUN B-O
+- PUNCT B-O
+directed VERB B-O
+monoclonal ADJ B-LF
+antibody NOUN I-LF
+( PUNCT B-O
+mAb PROPN B-AC
+) PUNCT B-O
+bound VERB B-O
+to ADP B-O
+an DET B-O
+influenza NOUN B-O
+H7 PROPN B-O
+HA PROPN B-AC
+. PUNCT B-O
+
+The DET B-O
+epitope NOUN B-O
+of ADP B-O
+the DET B-O
+antibody NOUN B-O
+is AUX B-O
+not PART B-O
+solvent NOUN B-O
+accessible ADJ B-O
+in ADP B-O
+the DET B-O
+compact ADJ B-O
+, PUNCT B-O
+prefusion NOUN B-O
+conformation NOUN B-O
+that PRON B-O
+typifies VERB B-O
+all DET B-O
+HA PROPN B-AC
+structures NOUN B-O
+to ADP B-O
+date NOUN B-O
+. PUNCT B-O
+
+Matrix NOUN B-LF
+effects NOUN I-LF
+( PUNCT B-O
+ME PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+extraction NOUN B-O
+recoveries NOUN B-O
+( PUNCT B-O
+ER PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+process NOUN B-O
+efficiencies NOUN B-O
+( PUNCT B-O
+PE PROPN B-AC
+) PUNCT B-O
+for ADP B-O
+PBTZ169 PROPN B-O
+, PUNCT B-O
+five NUM B-O
+active ADJ B-O
+metabolites NOUN B-O
+and CCONJ B-O
+internal ADJ B-O
+standards NOUN B-O
+were AUX B-O
+quantitatively ADV B-O
+assessed VERB B-O
+according VERB B-O
+to ADP B-O
+Matuszeswski PROPN B-O
+’s PART B-O
+procedures NOUN B-O
+as ADP B-O
+well ADV B-O
+as ADP B-O
+to ADP B-O
+the DET B-O
+recommendations NOUN B-O
+of ADP B-O
+the DET B-O
+EMEA PROPN B-AC
+/ SYM B-O
+FDA PROPN B-AC
+[ X B-O
+27 NUM B-O
+, PUNCT B-O
+28 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Among ADP B-O
+these DET B-O
+measures NOUN B-O
+are AUX B-O
+years NOUN B-O
+of ADP B-O
+life NOUN B-O
+lost VERB B-O
+( PUNCT B-O
+YLLs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+quantifies VERB B-O
+the DET B-O
+number NOUN B-O
+of ADP B-O
+years NOUN B-O
+of ADP B-O
+life NOUN B-O
+lost VERB B-O
+because SCONJ B-O
+the DET B-O
+person NOUN B-O
+dies VERB B-O
+prematurely ADV B-O
+due ADP B-O
+to ADP B-O
+a DET B-O
+disease NOUN B-O
+or CCONJ B-O
+injury NOUN B-O
+; PUNCT B-O
+years NOUN B-O
+lived VERB B-O
+with ADP B-O
+disability NOUN B-O
+( PUNCT B-O
+YLDs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+quantifies VERB B-O
+the DET B-O
+healthy ADJ B-O
+time NOUN B-O
+lost VERB B-O
+by ADP B-O
+a DET B-O
+person NOUN B-O
+living VERB B-O
+with ADP B-O
+a DET B-O
+disability NOUN B-O
+caused VERB B-O
+by ADP B-O
+a DET B-O
+disease NOUN B-O
+or CCONJ B-O
+injury NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+disability NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+years NOUN I-LF
+( PUNCT B-O
+DALYs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+a DET B-O
+summary NOUN B-O
+measure NOUN B-O
+that PRON B-O
+is AUX B-O
+the DET B-O
+sum NOUN B-O
+of ADP B-O
+YLLs PROPN B-AC
+and CCONJ B-O
+YLDs PROPN B-AC
+[ PUNCT B-O
+17 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Irrespective ADV B-O
+of ADP B-O
+familial ADJ B-O
+relationship NOUN B-O
+, PUNCT B-O
+adults NOUN B-O
+who PRON B-O
+resided VERB B-O
+with ADP B-O
+another DET B-O
+adult NOUN B-O
+with ADP B-O
+any DET B-O
+chronic ADJ B-O
+condition NOUN B-O
+had VERB B-O
+29 NUM B-O
+% NOUN B-O
+higher ADJ B-O
+adjusted ADJ B-O
+relative ADJ B-O
+odds NOUN B-O
+of ADP B-O
+having VERB B-O
+1 NUM B-O
+or CCONJ B-O
+more ADJ B-O
+chronic ADJ B-O
+conditions NOUN B-O
+themselves PRON B-O
+( PUNCT B-O
+adjusted ADJ B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+[ X B-O
+aOR PROPN B-AC
+] X B-O
+= SYM B-O
+1.29 NUM B-O
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X B-O
+95 NUM B-O
+% NOUN B-O
+CI PROPN B-AC
+] X B-O
+1.10–1.50 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+LJD PROPN B-O
+was AUX B-O
+the DET B-O
+Chairman PROPN B-O
+of ADP B-O
+the DET B-O
+National PROPN B-O
+Patient PROPN B-O
+Safety PROPN B-O
+Agency PROPN B-O
+( PUNCT B-O
+NPSA PROPN B-O
+) PUNCT B-O
+( PUNCT B-O
+2010–2012 NUM B-O
+) PUNCT B-O
+and CCONJ B-O
+is AUX B-O
+currently ADV B-O
+involved ADJ B-O
+in ADP B-O
+the DET B-O
+programme NOUN B-O
+of ADP B-O
+research NOUN B-O
+associated VERB B-O
+with ADP B-O
+the DET B-O
+National PROPN B-LF
+Reporting PROPN I-LF
+and CCONJ I-LF
+Learning PROPN I-LF
+System PROPN I-LF
+( PUNCT B-O
+NRLS PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+He PRON B-O
+is AUX B-O
+also ADV B-O
+the DET B-O
+World PROPN B-O
+Health PROPN B-O
+Organization PROPN B-O
+'s PART B-O
+Patient PROPN B-O
+Safety PROPN B-O
+Envoy PROPN B-O
+. PUNCT B-O
+
+Many ADJ B-O
+additional ADJ B-O
+milestones NOUN B-O
+have AUX B-O
+been AUX B-O
+reached VERB B-O
+, PUNCT B-O
+including VERB B-O
+the DET B-O
+last ADJ B-O
+naturally ADV B-O
+occurring VERB B-O
+isolation NOUN B-O
+of ADP B-O
+serotype-2 NOUN B-O
+WPV PROPN B-AC
+in ADP B-O
+1999 NUM B-O
+, PUNCT B-O
+the DET B-O
+last ADJ B-O
+reported VERB B-O
+case NOUN B-O
+of ADP B-O
+poliomyelitis NOUN B-O
+associated VERB B-O
+with ADP B-O
+serotype-3 NOUN B-O
+in ADP B-O
+2012 NUM B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+absence NOUN B-O
+of ADP B-O
+any DET B-O
+reported VERB B-O
+wild ADJ B-LF
+poliovirus NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+( PUNCT B-O
+WPV1 PROPN B-AC
+) PUNCT B-O
+cases NOUN B-O
+in ADP B-O
+Africa PROPN B-O
+outside ADP B-O
+of ADP B-O
+Borno PROPN B-O
+, PUNCT B-O
+Nigeria PROPN B-O
+( PUNCT B-O
+which PRON B-O
+reported VERB B-O
+4 NUM B-O
+WPV1 PROPN B-AC
+cases NOUN B-O
+with ADP B-O
+a DET B-O
+date NOUN B-O
+of ADP B-O
+onset NOUN B-O
+in ADP B-O
+July PROPN B-O
+– PUNCT B-O
+August PROPN B-O
+2016 NUM B-O
+and CCONJ B-O
+remains VERB B-O
+a DET B-O
+challenge NOUN B-O
+because SCONJ B-O
+of ADP B-O
+issues NOUN B-O
+with ADP B-O
+security NOUN B-O
+, PUNCT B-O
+inaccessibility NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+weak ADJ B-O
+surveillance NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+since SCONJ B-O
+August PROPN B-O
+2014 NUM B-O
+( PUNCT B-O
+in ADP B-O
+Somalia PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Ex ADJ B-LF
+- ADJ I-LF
+vivo ADJ I-LF
+lung NOUN I-LF
+perfusion NOUN I-LF
+( PUNCT B-O
+EVLP PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+an DET B-O
+emerging VERB B-O
+technique NOUN B-O
+promising VERB B-O
+an DET B-O
+expansion NOUN B-O
+of ADP B-O
+the DET B-O
+donor NOUN B-O
+pool NOUN B-O
+and CCONJ B-O
+improvements NOUN B-O
+in ADP B-O
+the DET B-O
+outcome NOUN B-O
+after ADP B-O
+lung NOUN B-O
+transplantation NOUN B-O
+. PUNCT B-O
+
+These DET B-O
+results NOUN B-O
+contrast VERB B-O
+to ADP B-O
+the DET B-O
+prevalent ADJ B-O
+thought NOUN B-O
+that SCONJ B-O
+oxygen NOUN B-O
+- PUNCT B-O
+reactive ADJ B-O
+Hbs PROPN B-AC
+( PUNCT B-O
+HbII NOUN B-O
+and CCONJ B-O
+HbIII NOUN B-O
+) PUNCT B-O
+are AUX B-O
+widely ADV B-O
+distributed VERB B-O
+and CCONJ B-O
+that SCONJ B-O
+the DET B-O
+sulfide NOUN B-O
+- PUNCT B-O
+reactive ADJ B-O
+hemoglobin NOUN B-LF
+( PUNCT B-O
+HbI NOUN B-O
+) PUNCT B-O
+is AUX B-O
+only ADV B-O
+present ADJ B-O
+in ADP B-O
+the DET B-O
+tissue NOUN B-O
+where SCONJ B-O
+the DET B-O
+endosymbiont NOUN B-O
+is AUX B-O
+located VERB B-O
+[ X B-O
+1 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+CTRL PROPN B-O
+, PUNCT B-O
+control NOUN B-O
+; PUNCT B-O
+EXC PROPN B-O
+, PUNCT B-O
+excised VERB B-O
+; PUNCT B-O
+hpi PROPN B-O
+, PUNCT B-O
+hours NOUN B-O
+post NOUN B-O
+invasion NOUN B-O
+; PUNCT B-O
+INT PROPN B-O
+, PUNCT B-O
+integration NOUN B-O
+; PUNCT B-O
+n.s PROPN B-O
+. PUNCT B-O
+
+, PUNCT B-O
+not PART B-O
+significant ADJ B-O
+by ADP B-O
+unpaired ADJ B-O
+t NOUN B-O
+test NOUN B-O
+( PUNCT B-O
+p NOUN B-O
+- PUNCT B-O
+value NOUN B-O
+= SYM B-O
+0.9895 NUM B-O
+) PUNCT B-O
+; PUNCT B-O
+PDEβ PROPN B-AC
+, PUNCT B-O
+phosphodiesterase NOUN B-LF
+β PUNCT I-LF
+; PUNCT B-O
+PfPDEβ PROPN B-AC
+, PUNCT B-O
+Plasmodium NOUN B-LF
+falciparum NOUN I-LF
+phosphodiesterase NOUN B-LF
+β PUNCT I-LF
+; PUNCT B-O
+RAP PROPN B-AC
+, PUNCT B-O
+rapamycin NOUN B-LF
+; PUNCT B-O
+RFU PROPN B-O
+, PUNCT B-O
+relative ADJ B-O
+fluorescence NOUN B-O
+unit NOUN B-O
+. PUNCT B-O
+
+Additionally ADV B-O
+, PUNCT B-O
+participants NOUN B-O
+reported VERB B-O
+that SCONJ B-O
+most ADJ B-O
+of ADP B-O
+the DET B-O
+current ADJ B-O
+priority NOUN B-O
+initiatives NOUN B-O
+such ADJ B-O
+as ADP B-O
+Clean PROPN B-LF
+and CCONJ I-LF
+Safe PROPN I-LF
+Health PROPN I-LF
+Facility PROPN I-LF
+( PUNCT B-O
+CASH PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+quality NOUN B-O
+movement NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+Compassionate PROPN B-LF
+, PUNCT I-LF
+Respectful PROPN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+Caring PROPN I-LF
+( PUNCT B-O
+CRC PROPN B-AC
+) PUNCT B-O
+by ADP B-O
+the DET B-O
+Federal PROPN B-O
+Minstry PROPN B-O
+of ADP B-O
+Health PROPN B-O
+( PUNCT B-O
+FMOH PROPN B-O
+) PUNCT B-O
+could AUX B-O
+well ADV B-O
+be AUX B-O
+complemented VERB B-O
+by ADP B-O
+the DET B-O
+intents NOUN B-O
+of ADP B-O
+the DET B-O
+current ADJ B-O
+guideline NOUN B-O
+. PUNCT B-O
+
+These DET B-O
+cases NOUN B-O
+have AUX B-O
+deserved VERB B-O
+the DET B-O
+designation NOUN B-O
+of ADP B-O
+GT PROPN B-AC
+- PUNCT B-O
+like ADJ B-O
+syndrome NOUN B-O
+( PUNCT B-O
+GTLS PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+ITGA2B PROPN B-LF
+/ SYM I-LF
+ITGA2B PROPN B-AC
+ITGB3 PROPN I-LF
+- PUNCT I-LF
+ITGB3 PROPN B-AC
+related VERB I-LF
+thrombocytopenia NOUN I-LF
+( PUNCT B-O
+ITGA2B PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+first ADJ B-O
+description NOUN B-O
+dates VERB B-O
+to ADP B-O
+the DET B-O
+1990s NOUN B-O
+[ PUNCT B-O
+14,15 NUM B-O
+] PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+, PUNCT B-O
+along ADP B-O
+the DET B-O
+recent ADJ B-O
+years NOUN B-O
+, PUNCT B-O
+the DET B-O
+disease NOUN B-O
+has AUX B-O
+been AUX B-O
+characterized VERB B-O
+, PUNCT B-O
+with ADP B-O
+only ADV B-O
+a DET B-O
+few ADJ B-O
+variants NOUN B-O
+being AUX B-O
+described VERB B-O
+in ADP B-O
+the DET B-O
+/ITGB3-RTITGA2B PROPN B-AC
+and CCONJ B-O
+ITGB3 PROPN B-AC
+genes NOUN B-O
+. PUNCT B-O
+
+Another DET B-O
+well ADV B-O
+- PUNCT B-O
+characterized VERB B-O
+CTL PROPN B-AC
+epitope NOUN B-O
+, PUNCT B-O
+from ADP B-O
+Sendai PROPN B-LF
+virus NOUN I-LF
+nucleoprotein NOUN I-LF
+( PUNCT B-O
+SV PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+was AUX B-O
+investigated VERB B-O
+to PART B-O
+provide VERB B-O
+further ADJ B-O
+evidence NOUN B-O
+that SCONJ B-O
+-NPTAP PROPN B-AC
+over NOUN B-O
+- PUNCT B-O
+expression NOUN B-O
+can AUX B-O
+augment VERB B-O
+antiviral ADJ B-O
+responses NOUN B-O
+. PUNCT B-O
+
+Importantly ADV B-O
+, PUNCT B-O
+caspase-4 NOUN B-O
+can AUX B-O
+be AUX B-O
+activated VERB B-O
+by ADP B-O
+increased VERB B-O
+intracellular ADJ B-O
+Ca2 NOUN B-O
++ NOUN B-O
+level NOUN B-O
+, PUNCT B-O
+for ADP B-O
+example NOUN B-O
+, PUNCT B-O
+ER PROPN B-AC
+Ca2 NOUN B-O
++ NOUN B-O
+release NOUN B-O
+mediated VERB B-O
+by ADP B-O
+transmembrane NOUN B-LF
+protein NOUN I-LF
+173 NUM I-LF
+( PUNCT B-O
+TMEM173 PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+also ADV B-O
+known VERB B-O
+as ADP B-O
+stimulator NOUN B-LF
+of ADP I-LF
+interferon NOUN I-LF
+genes NOUN I-LF
+( PUNCT B-O
+STING PROPN B-AC
+) PUNCT B-O
+) PUNCT B-O
+[ X B-O
+56 X B-O
+] PUNCT B-O
+or CCONJ B-O
+the DET B-O
+SERCA PROPN B-AC
+inhibitor NOUN B-O
+thapsigargin NOUN B-O
+[ X B-O
+57 X B-O
+] PUNCT B-O
+. PUNCT B-O
+
+KO PROPN B-AC
+, PUNCT B-O
+knockout NOUN B-LF
+; PUNCT B-O
+mDia1 PROPN B-O
+, PUNCT B-O
+mammalian ADJ B-O
+diaphanous ADJ B-O
+homolog1 NOUN B-O
+; PUNCT B-O
+mDia3 PROPN B-O
+, PUNCT B-O
+mammalian ADJ B-O
+diaphanous ADJ B-O
+homolog3 NOUN B-O
+; PUNCT B-O
+WT PROPN B-AC
+, PUNCT B-O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT B-O
+
+Detection NOUN B-O
+was AUX B-O
+carried VERB B-O
+out ADP B-O
+in ADP B-O
+multiple ADJ B-LF
+reactions NOUN I-LF
+monitoring NOUN I-LF
+( PUNCT B-O
+MRM PROPN B-AC
+) PUNCT B-O
+mode NOUN B-O
+. PUNCT B-O
+
+A DET B-O
+significant ADJ B-O
+independent ADJ B-O
+association NOUN B-O
+was AUX B-O
+found VERB B-O
+between ADP B-O
+serum ADJ B-O
+CysC PROPN B-AC
+and CCONJ B-O
+GDM PROPN B-AC
+in ADP B-O
+the DET B-O
+binary ADJ B-O
+logistic ADJ B-O
+regression NOUN B-O
+analysis NOUN B-O
+after SCONJ B-O
+adjusted VERB B-O
+for ADP B-O
+age NOUN B-O
+, PUNCT B-O
+BMI PROPN B-AC
+, PUNCT B-O
+SP PROPN B-AC
+, PUNCT B-O
+DP PROPN B-AC
+, PUNCT B-O
+HbA1c PROPN B-AC
+, PUNCT B-O
+UA PROPN B-AC
+, PUNCT B-O
+TG PROPN B-AC
+and CCONJ B-O
+HOMA PROPN B-AC
+ratio NOUN I-LF
+( PUNCT B-O
+-IR[oddsOR PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+14.269 NUM B-O
+; PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval(CI NOUN I-LF
+) PUNCT B-O
+, PUNCT B-O
+4.977–40.908 NUM B-O
+, PUNCT B-O
+P<0.001 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+Clinical ADJ B-O
+investigators NOUN B-O
+, PUNCT B-O
+IRBs PROPN B-AC
+, PUNCT B-O
+data NOUN B-O
+safety NOUN B-O
+and CCONJ B-O
+monitoring NOUN B-O
+boards NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+regulatory ADJ B-O
+agencies NOUN B-O
+( PUNCT B-O
+e.g. X B-O
+, PUNCT B-O
+the DET B-O
+European PROPN B-LF
+Medicines PROPN I-LF
+Agency PROPN I-LF
+[ PUNCT B-O
+EMA PROPN B-AC
+] PUNCT B-O
+and CCONJ B-O
+the DET B-O
+Food PROPN B-LF
+and CCONJ I-LF
+Drug PROPN I-LF
+Administration PROPN I-LF
+[ PUNCT B-O
+FDA PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+are AUX B-O
+all PRON B-O
+charged VERB B-O
+with ADP B-O
+risk NOUN B-O
+– PUNCT B-O
+benefit NOUN B-O
+assessment NOUN B-O
+. PUNCT B-O
+
+RNA-seq PROPN B-AC
+, PUNCT B-O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+. PUNCT B-O
+
+Parenteral ADJ B-O
+nutrition NOUN B-O
+can AUX B-O
+be AUX B-O
+provided VERB B-O
+independently ADV B-O
+( PUNCT B-O
+total ADJ B-LF
+parenteral ADJ I-LF
+nutrition NOUN I-LF
+, PUNCT B-O
+TPN PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+or CCONJ B-O
+be AUX B-O
+combined VERB B-O
+with ADP B-O
+enteral ADJ B-O
+nutrition NOUN B-O
+. PUNCT B-O
+
+Studies NOUN B-O
+in ADP B-O
+Drosophila PROPN B-O
+have AUX B-O
+identified VERB B-O
+conserved ADJ B-O
+polarity NOUN B-O
+factors NOUN B-O
+that PRON B-O
+define VERB B-O
+the DET B-O
+apical ADJ B-O
+( PUNCT B-O
+Crumbs PROPN B-O
+, PUNCT B-O
+Stardust PROPN B-O
+, PUNCT B-O
+Par-6 PROPN B-O
+, PUNCT B-O
+atypical ADJ B-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+C PROPN I-LF
+[ X B-O
+aPKC PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+, PUNCT B-O
+junctional ADJ B-O
+( PUNCT B-O
+Bazooka PROPN B-LF
+[ X B-O
+Baz]/Par-3 PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+basolateral ADJ B-O
+( PUNCT B-O
+Scribbled VERB B-LF
+[ X B-O
+Scrib PROPN B-AC
+] PUNCT B-O
+, PUNCT B-O
+Discs NOUN B-LF
+large ADJ I-LF
+[ X B-O
+Dlg PROPN B-AC
+] PUNCT B-O
+, PUNCT B-O
+Lethal ADJ B-O
+[ X B-O
+2 X B-O
+] PUNCT B-O
+giant ADJ B-O
+larvae NOUN B-O
+[ X B-O
+Lgl PROPN B-AC
+] PUNCT B-O
+) PUNCT B-O
+domains NOUN B-O
+of ADP B-O
+epithelial ADJ B-O
+cells NOUN B-O
+. PUNCT B-O
+
+The DET B-O
+prevalence NOUN B-O
+of ADP B-O
+alcohol NOUN B-LF
+use NOUN I-LF
+disorder NOUN I-LF
+( PUNCT B-O
+AUD PROPN B-AC
+) PUNCT B-O
+was AUX B-O
+14.2 NUM B-O
+% PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+addition NOUN B-O
+, PUNCT B-O
+wtBMMΦ PROPN B-AC
+and CCONJ B-O
+wtBMDCs PROPN B-AC
+secrete VERB B-O
+IFNα PROPN B-O
+after ADP B-O
+MNV-1 PROPN B-AC
+- PUNCT B-O
+infection NOUN B-O
+, PUNCT B-O
+as SCONJ B-O
+determined VERB B-O
+by ADP B-O
+IFNα PROPN B-O
+enzyme NOUN B-LF
+- PUNCT I-LF
+linked VERB I-LF
+immunosorbent ADJ I-LF
+assay NOUN I-LF
+( PUNCT B-O
+ELISA PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+data NOUN B-O
+not PART B-O
+shown VERB B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Resource NOUN B-LF
+utilization NOUN I-LF
+groups NOUN I-LF
+( PUNCT B-O
+RUGs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+introduced VERB B-O
+as ADP B-O
+the DET B-O
+way NOUN B-O
+per X B-O
+diem X B-O
+prospective ADJ B-O
+payments NOUN B-O
+are AUX B-O
+set VERB B-O
+for ADP B-O
+Medicare PROPN B-O
+- PUNCT B-O
+reimbursed VERB B-O
+SNF PROPN B-AC
+care NOUN B-O
+, PUNCT B-O
+classifying VERB B-O
+patients NOUN B-O
+into ADP B-O
+reimbursement NOUN B-O
+categories NOUN B-O
+based VERB B-O
+on ADP B-O
+rehabilitation NOUN B-O
+service NOUN B-O
+use NOUN B-O
+: PUNCT B-O
+ultra ADJ B-O
+( PUNCT B-O
+720 NUM B-O
++ NUM B-O
+minutes NOUN B-O
+/ SYM B-O
+week NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+very ADV B-O
+high ADJ B-O
+( PUNCT B-O
+500–719 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+high ADJ B-O
+( PUNCT B-O
+325–499 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+medium ADJ B-O
+( PUNCT B-O
+150–324 NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+low ADJ B-O
+( PUNCT B-O
+45–149 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+each DET B-O
+country NOUN B-O
+we PRON B-O
+sought VERB B-O
+published VERB B-O
+and CCONJ B-O
+unpublished ADJ B-O
+documents NOUN B-O
+( PUNCT B-O
+situation NOUN B-O
+reports NOUN B-O
+, PUNCT B-O
+official ADJ B-O
+statistics NOUN B-O
+, PUNCT B-O
+evaluation NOUN B-O
+reports NOUN B-O
+, PUNCT B-O
+technical ADJ B-O
+documents NOUN B-O
+, PUNCT B-O
+guidelines NOUN B-O
+for ADP B-O
+victim NOUN B-O
+identification NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+public ADJ B-O
+health NOUN B-O
+reports NOUN B-O
+) PUNCT B-O
+from ADP B-O
+national ADJ B-O
+ministries NOUN B-O
+of ADP B-O
+health NOUN B-O
+and CCONJ B-O
+government NOUN B-O
+offices NOUN B-O
+, PUNCT B-O
+the DET B-O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT B-O
+WHO PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+non ADJ B-O
+- ADJ B-O
+governmental ADJ B-O
+organisations NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+voluntary ADJ B-O
+groups NOUN B-O
+. PUNCT B-O
+
+Immunofluorescence NOUN B-O
+with ADP B-O
+antibodies NOUN B-O
+to ADP B-O
+the DET B-O
+myelin NOUN B-O
+protein NOUN B-O
+, PUNCT B-O
+myelin NOUN B-LF
+oligodendrocyte NOUN I-LF
+glycoprotein NOUN I-LF
+( PUNCT B-O
+MOG PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+confirmed VERB B-O
+the DET B-O
+myelin NOUN B-O
+integrity NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1A NUM B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+HLA PROPN B-O
+- ADJ B-O
+DR PROPN B-O
+( PUNCT B-O
+MHC PROPN B-O
+class NOUN B-O
+II NUM B-O
+) PUNCT B-O
+antibodies NOUN B-O
+confirmed VERB B-O
+the DET B-O
+presence NOUN B-O
+of ADP B-O
+microglia NOUN B-O
+with ADP B-O
+an DET B-O
+activated VERB B-O
+morphology NOUN B-O
+( PUNCT B-O
+thicker ADJ B-O
+and CCONJ B-O
+shorter ADJ B-O
+processes NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Fig PROPN B-O
+1B NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Immunofluorescence NOUN B-O
+for ADP B-O
+Caspr1 PROPN B-O
+localised VERB B-O
+at ADP B-O
+the DET B-O
+paranodes NOUN B-O
+demonstrated VERB B-O
+that SCONJ B-O
+Caspr1 PROPN B-O
+- ADJ B-O
+stained VERB B-O
+paranodes NOUN B-O
+( PUNCT B-O
+2.8 NUM B-O
+± SYM B-O
+1.1 NUM B-O
+μm NOUN B-O
+) PUNCT B-O
+were AUX B-O
+significantly ADV B-O
+21.7 NUM B-O
+% NOUN B-O
+longer ADJ B-O
+on ADP B-O
+average ADJ B-O
+in ADP B-O
+the DET B-O
+MS PROPN B-AC
+NAWM PROPN B-AC
+tissue NOUN B-O
+than ADP B-O
+in ADP B-O
+the DET B-O
+non ADJ B-O
+- ADJ B-O
+neurological ADJ B-O
+control NOUN B-O
+tissue NOUN B-O
+( PUNCT B-O
+2.3 NUM B-O
+± SYM B-O
+0.8μm NUM B-O
+, PUNCT B-O
+Fig PROPN B-O
+1C–1 NUM B-O
+G PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Furthermore ADV B-O
+, PUNCT B-O
+43 NUM B-O
+% NOUN B-O
+of ADP B-O
+the DET B-O
+paranodes NOUN B-O
+in ADP B-O
+the DET B-O
+MS PROPN B-AC
+tissue NOUN B-O
+were AUX B-O
+longer ADJ B-O
+than ADP B-O
+the DET B-O
+75 NUM B-O
+% NOUN B-O
+percentile NOUN B-O
+of ADP B-O
+the DET B-O
+control NOUN B-O
+group NOUN B-O
+( PUNCT B-O
+2.7 NUM B-O
+μm NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+and CCONJ B-O
+11.14 NUM B-O
+% NOUN B-O
+were AUX B-O
+longer ADJ B-O
+than ADP B-O
+4 NUM B-O
+μm NOUN B-O
+, PUNCT B-O
+compared VERB B-O
+to ADP B-O
+the DET B-O
+4.1 NUM B-O
+% NOUN B-O
+in ADP B-O
+the DET B-O
+non ADJ B-O
+- ADJ B-O
+neurological ADJ B-O
+controls NOUN B-O
+( PUNCT B-O
+Fig PROPN B-O
+1 NUM B-O
+G PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+There PRON B-O
+was VERB B-O
+little ADJ B-O
+difference NOUN B-O
+between ADP B-O
+the DET B-O
+2 NUM B-O
+brain NOUN B-O
+areas NOUN B-O
+examined VERB B-O
+; PUNCT B-O
+the DET B-O
+paranodal ADJ B-O
+lengths NOUN B-O
+in ADP B-O
+the DET B-O
+cerebral ADJ B-O
+peduncles NOUN B-O
+of ADP B-O
+the DET B-O
+mesencephalon NOUN B-O
+were AUX B-O
+2.81 NUM B-O
+± SYM B-O
+0.019 NUM B-O
+μm NOUN B-O
+long ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+12 NUM B-O
+% NOUN B-O
+of ADP B-O
+them PRON B-O
+were AUX B-O
+> ADP B-O
+4 NUM B-O
+μm NOUN B-O
+, PUNCT B-O
+compared VERB B-O
+to ADP B-O
+those PRON B-O
+in ADP B-O
+the DET B-O
+precentral ADJ B-O
+gyrus NOUN B-O
+, PUNCT B-O
+which PRON B-O
+were AUX B-O
+2.79 NUM B-O
+± SYM B-O
+0.017 NUM B-O
+μm NOUN B-O
+long ADJ B-O
+, PUNCT B-O
+and CCONJ B-O
+10 NUM B-O
+% NOUN B-O
+of ADP B-O
+them PRON B-O
+were AUX B-O
+> ADP B-O
+4 NUM B-O
+μm NOUN B-O
+( PUNCT B-O
+S1 PROPN B-O
+Fig PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Class NOUN B-O
+B NOUN B-O
+enzymes NOUN B-O
+are AUX B-O
+zinc NOUN B-O
+dependent ADJ B-O
+metallo NOUN B-LF
+- PUNCT I-LF
+β PUNCT I-LF
+- PUNCT I-LF
+lactamases NOUN I-LF
+( PUNCT B-O
+MBLs PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+which PRON B-O
+require VERB B-O
+one NUM B-O
+or CCONJ B-O
+two NUM B-O
+Zn2 NOUN B-O
++ NOUN B-O
+in ADP B-O
+their PRON B-O
+active ADJ B-O
+site NOUN B-O
+for ADP B-O
+catalysis NOUN B-O
+[ PUNCT B-O
+3 NUM B-O
+, PUNCT B-O
+4 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+the DET B-O
+present ADJ B-O
+study NOUN B-O
+, PUNCT B-O
+we PRON B-O
+chose VERB B-O
+to PART B-O
+investigate VERB B-O
+this PRON B-O
+using VERB B-O
+two NUM B-O
+different ADJ B-O
+kinds NOUN B-O
+of ADP B-O
+spatial ADJ B-O
+memory NOUN B-O
+tests NOUN B-O
+: PUNCT B-O
+the DET B-O
+spontaneous ADJ B-LF
+place NOUN I-LF
+recognition NOUN I-LF
+( PUNCT B-O
+SPR PROPN B-AC
+) PUNCT B-O
+test NOUN B-O
+and CCONJ B-O
+the DET B-O
+delay NOUN B-LF
+- PUNCT I-LF
+interposed VERB I-LF
+radial ADJ I-LF
+arm NOUN I-LF
+maze NOUN I-LF
+( PUNCT B-O
+dRAM PROPN B-AC
+) PUNCT B-O
+task NOUN B-O
+. PUNCT B-O
+
+For ADP B-O
+EM PROPN B-AC
+studies NOUN B-O
+, PUNCT B-O
+MRC5 PROPN B-O
+cells NOUN B-O
+were AUX B-O
+infected VERB B-O
+at ADP B-O
+an DET B-O
+m.o.i NOUN B-O
+. PUNCT B-O
+
+of ADP B-O
+5 NUM B-O
+as SCONJ B-O
+described VERB B-O
+above ADV B-O
+and CCONJ B-O
+fixed VERB B-O
+in ADP B-O
+situ NOUN B-O
+by ADP B-O
+incubation NOUN B-O
+for ADP B-O
+48 NUM B-O
+h NOUN B-O
+in ADP B-O
+4 NUM B-O
+% NOUN B-O
+PFA NOUN B-O
+and CCONJ B-O
+1 NUM B-O
+% NOUN B-O
+glutaraldehyde NOUN B-O
+in ADP B-O
+0.1 NUM B-O
+M PROPN B-O
+phosphate NOUN B-O
+buffer NOUN B-O
+( PUNCT B-O
+pH NOUN B-O
+7.2 NUM B-O
+) PUNCT B-O
+; PUNCT B-O
+they PRON B-O
+were AUX B-O
+then ADV B-O
+post VERB B-O
+- VERB B-O
+fixed VERB B-O
+by ADP B-O
+incubation NOUN B-O
+for ADP B-O
+1 NUM B-O
+h NOUN B-O
+with ADP B-O
+2 NUM B-O
+% NOUN B-O
+osmium NOUN B-O
+tetroxide NOUN B-O
+( PUNCT B-O
+Electron PROPN B-LF
+Microscopy PROPN I-LF
+Science PROPN B-O
+, PUNCT B-O
+http://www.emsdiasum.com X B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Timely ADV B-O
+and CCONJ B-O
+an PRON B-O
+accurate ADJ B-O
+risk NOUN B-O
+stratification NOUN B-O
+of ADP B-O
+patients NOUN B-O
+in ADP B-O
+the DET B-O
+emergency NOUN B-LF
+department NOUN I-LF
+( PUNCT B-O
+ED PROPN B-AC
+) PUNCT B-O
+supports VERB B-O
+the DET B-O
+clinician NOUN B-O
+in ADP B-O
+reducing VERB B-O
+time NOUN B-O
+to ADP B-O
+effective ADJ B-O
+treatment NOUN B-O
+— PUNCT B-O
+a DET B-O
+key ADJ B-O
+predictor NOUN B-O
+for ADP B-O
+patient NOUN B-O
+outcome NOUN B-O
+. PUNCT B-O
+
+HL PROPN B-AC
+: PUNCT B-O
+hyperlipidemia NOUN B-LF
+Statistical ADJ B-O
+analyses NOUN B-O
+were AUX B-O
+performed VERB B-O
+using VERB B-O
+logistic ADJ B-O
+regression NOUN B-O
+and CCONJ B-O
+results NOUN B-O
+were AUX B-O
+reported VERB B-O
+as ADP B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT B-O
+OR PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-O
+interval NOUN B-O
+( PUNCT B-O
+95 NUM B-O
+% NOUN B-O
+CI NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+HBV PROPN B-AC
+, PUNCT B-O
+hepatitis NOUN B-LF
+B PROPN I-LF
+virus NOUN I-LF
+; PUNCT B-O
+HDV PROPN B-AC
+, PUNCT B-O
+hepatitis NOUN B-LF
+D PROPN I-LF
+virus NOUN I-LF
+. PUNCT B-O
+
+Each DET B-O
+green ADJ B-O
+dot NOUN B-O
+represents VERB B-O
+a DET B-O
+metabolic ADJ B-O
+trait NOUN B-O
+and CCONJ B-O
+the DET B-O
+positions NOUN B-O
+of ADP B-O
+the DET B-O
+dots NOUN B-O
+are AUX B-O
+determined VERB B-O
+by ADP B-O
+difference NOUN B-O
+in ADP B-O
+mean ADJ B-O
+offspring NOUN B-O
+metabolite NOUN B-O
+( PUNCT B-O
+in ADP B-O
+SD NOUN B-O
+units NOUN B-O
+) PUNCT B-O
+for ADP B-O
+each DET B-O
+increase NOUN B-O
+of ADP B-O
+1 NUM B-O
+- NOUN B-O
+SD NOUN B-O
+maternal ADJ B-O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT B-O
+BMI PROPN B-AC
+) PUNCT B-O
+( PUNCT B-O
+x NOUN B-O
+- NOUN B-O
+axis NOUN B-O
+) PUNCT B-O
+and CCONJ B-O
+difference NOUN B-O
+in ADP B-O
+mean ADJ B-O
+offspring NOUN B-O
+metabolite NOUN B-O
+( PUNCT B-O
+in ADP B-O
+SD NOUN B-O
+units NOUN B-O
+) PUNCT B-O
+for ADP B-O
+each DET B-O
+increase NOUN B-O
+in ADP B-O
+1 NUM B-O
+- NOUN B-O
+SD NOUN B-O
+paternal ADJ B-O
+BMI PROPN B-AC
+( PUNCT B-O
+y NOUN B-O
+- NOUN B-O
+axis NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Acute ADJ B-LF
+gastroenteritis NOUN I-LF
+( PUNCT B-O
+AGE PROPN B-AC
+) PUNCT B-O
+is AUX B-O
+a DET B-O
+common ADJ B-O
+condition NOUN B-O
+that PRON B-O
+imposes VERB B-O
+a DET B-O
+significant ADJ B-O
+burden NOUN B-O
+on ADP B-O
+communities NOUN B-O
+and CCONJ B-O
+healthcare NOUN B-O
+systems NOUN B-O
+worldwide ADV B-O
+. PUNCT B-O
+
+We PRON B-O
+developed VERB B-O
+and CCONJ B-O
+validated VERB B-O
+a DET B-O
+computational ADJ B-O
+model NOUN B-O
+of ADP B-O
+signal NOUN B-LF
+transducer NOUN I-LF
+and CCONJ I-LF
+activator NOUN I-LF
+of ADP I-LF
+transcription-3 NOUN I-LF
+( PUNCT B-O
+Stat3 PROPN B-AC
+) PUNCT B-O
+pathway NOUN B-O
+kinetics NOUN B-O
+, PUNCT B-O
+a DET B-O
+signaling NOUN B-O
+network NOUN B-O
+involved VERB B-O
+in ADP B-O
+embryonic ADJ B-O
+stem NOUN B-O
+cell NOUN B-O
+( PUNCT B-O
+ESC PROPN B-AC
+) PUNCT B-O
+self NOUN B-O
+- PUNCT B-O
+renewal NOUN B-O
+. PUNCT B-O
+
+Electrophoretic ADJ B-LF
+mobility NOUN I-LF
+shift NOUN I-LF
+assays NOUN I-LF
+( PUNCT B-O
+EMSAs PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+performed VERB B-O
+using VERB B-O
+the DET B-O
+Lightshift PROPN B-O
+chemi NOUN B-O
+- PUNCT B-O
+luminescence NOUN B-O
+EMSA PROPN B-AC
+kit NOUN B-O
+( PUNCT B-O
+Pierce PROPN B-O
+) PUNCT B-O
+according VERB B-O
+to ADP B-O
+the DET B-O
+manufacturer NOUN B-O
+’s PART B-O
+instructions NOUN B-O
+described VERB B-O
+in ADP B-O
+[ X B-O
+65 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+The DET B-O
+average NOUN B-O
+of ADP B-O
+3 NUM B-O
+blood NOUN B-LF
+pressures NOUN I-LF
+( PUNCT B-O
+BP PROPN B-AC
+) PUNCT B-O
+taken VERB B-O
+5 NUM B-O
+minutes NOUN B-O
+apart ADV B-O
+were AUX B-O
+used VERB B-O
+. PUNCT B-O
+
+Almost ADV B-O
+all PRON B-O
+women NOUN B-O
+recruited VERB B-O
+in ADP B-O
+both DET B-O
+study NOUN B-O
+groups NOUN B-O
+used VERB B-O
+their PRON B-O
+allocated VERB B-O
+study NOUN B-O
+treatment NOUN B-O
+( PUNCT B-O
+381 NUM B-O
+[ X B-O
+95.7 NUM B-O
+% NOUN B-O
+] PUNCT B-O
+in ADP B-O
+the DET B-O
+progesterone NOUN B-O
+group NOUN B-O
+and CCONJ B-O
+359 NUM B-O
+[ X B-O
+92.3 NUM B-O
+% NOUN B-O
+] PUNCT B-O
+in ADP B-O
+the DET B-O
+placebo NOUN B-O
+group NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+with ADP B-O
+similar ADJ B-O
+median ADJ B-O
+days NOUN B-O
+of ADP B-O
+use NOUN B-O
+in ADP B-O
+both DET B-O
+study NOUN B-O
+groups NOUN B-O
+( PUNCT B-O
+51.0 NUM B-O
+days NOUN B-O
+[ X B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+( PUNCT B-O
+IQR PROPN B-AC
+) PUNCT B-O
+28.0–69.0 NUM B-O
+] PUNCT B-O
+in ADP B-O
+the DET B-O
+progesterone NOUN B-O
+group NOUN B-O
+versus ADP B-O
+52.0 NUM B-O
+days NOUN B-O
+[ X B-O
+IQR PROPN B-AC
+27.0–76.0 NUM B-O
+] PUNCT B-O
+in ADP B-O
+the DET B-O
+placebo NOUN B-O
+group NOUN B-O
+) PUNCT B-O
+( PUNCT B-O
+Table PROPN B-O
+1 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+As SCONJ B-O
+shown VERB B-O
+in ADP B-O
+S5 NUM B-O
+Fig PROPN B-O
+, PUNCT B-O
+and CCONJ B-O
+consistent ADJ B-O
+with ADP B-O
+our PRON B-O
+previous ADJ B-O
+results NOUN B-O
+, PUNCT B-O
+ectopic ADJ B-O
+induction NOUN B-O
+of ADP B-O
+all DET B-O
+three NUM B-O
+Su(H NOUN B-O
+) PUNCT B-O
+mutants NOUN B-O
+in ADP B-O
+the DET B-O
+eye NOUN B-O
+imaginal ADJ B-O
+discs NOUN B-O
+effects VERB B-O
+eye NOUN B-O
+morphology NOUN B-O
+indistinguishable ADJ B-O
+from ADP B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+Su(H NOUN B-O
+) PUNCT B-O
+, PUNCT B-O
+but CCONJ B-O
+the DET B-O
+triple ADJ B-O
+mutants NOUN B-O
+Su(H)LLL PROPN B-AC
+/ NOUN B-O
+AAA NOUN B-O
+and CCONJ B-O
+Su(H)LLF PROPN B-AC
+/ NOUN B-O
+AAA NOUN B-O
+retain VERB B-O
+little ADJ B-O
+to PART B-O
+no PRON B-O
+binding NOUN B-O
+of ADP B-O
+Hairless PROPN B-LF
+in ADP B-O
+vivo ADJ B-O
+. PUNCT B-O
+
+This PRON B-O
+is AUX B-O
+fully ADV B-O
+restored VERB B-O
+in ADP B-O
+Dble::R6/2 PROPN B-O
+mice NOUN B-O
+at ADP B-O
+12 NUM B-O
+wk NOUN B-O
+of ADP B-O
+age NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+K NOUN B-O
+) PUNCT B-O
+Representative ADJ B-O
+traces NOUN B-O
+of ADP B-O
+miniature ADJ B-LF
+EPSCs NOUN I-LF
+EPSCs PROPN B-AC
+( PUNCT B-O
+mEPSCs PROPN B-AC
+) PUNCT B-O
+at ADP B-O
+8 NUM B-O
+wk NOUN B-O
+. PUNCT B-O
+
+Status NOUN B-O
+of ADP B-O
+promoter NOUN B-O
+region NOUN B-O
+methylation NOUN B-O
+of ADP B-O
+O6 NOUN B-O
+- PUNCT B-O
+methylguanine NOUN B-O
+DNA NOUN B-O
+methyltransferase NOUN B-O
+( PUNCT B-O
+MGMT PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+Isocitrate NOUN B-LF
+dehydrogenase NOUN I-LF
+1 NUM B-O
+and CCONJ B-O
+2 NUM B-O
+( PUNCT B-O
+IDH PROPN B-AC
+1/2 NUM B-O
+) PUNCT B-O
+mutations NOUN B-O
+were AUX B-O
+also ADV B-O
+assessed VERB B-O
+. PUNCT B-O
+
+The DET B-O
+included VERB B-O
+literature NOUN B-O
+fulfilled VERB B-O
+the DET B-O
+following ADJ B-O
+criteria NOUN B-O
+: PUNCT B-O
+( PUNCT B-O
+1 X B-O
+) PUNCT B-O
+The DET B-O
+case NOUN B-O
+- PUNCT B-O
+control NOUN B-O
+studies NOUN B-O
+or CCONJ B-O
+cohort NOUN B-O
+designs NOUN B-O
+on ADP B-O
+the DET B-O
+correlation NOUN B-O
+between ADP B-O
+the DET B-O
+polymorphism NOUN B-O
+of ADP B-O
+ADIPOQ NOUN B-O
+gene NOUN B-O
+rs2241766 NOUN B-O
+or CCONJ B-O
+rs1501299 NOUN B-O
+and CCONJ B-O
+T2DM PROPN B-AC
+. PUNCT B-O
+
+( PUNCT B-O
+2 X B-O
+) PUNCT B-O
+The DET B-O
+genotype NOUN B-O
+distribution NOUN B-O
+conformed VERB B-O
+to ADP B-O
+the DET B-O
+HWE PROPN B-AC
+( PUNCT B-O
+Hardy PROPN B-LF
+- PUNCT I-LF
+Weinberg PROPN I-LF
+Equilibrium PROPN I-LF
+) PUNCT B-O
+balance NOUN B-O
+in ADP B-O
+the DET B-O
+control NOUN B-O
+population NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+3 X B-O
+) PUNCT B-O
+The DET B-O
+genotype NOUN B-O
+frequency NOUN B-O
+, PUNCT B-O
+the DET B-O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT B-O
+OR PROPN B-AC
+) PUNCT B-O
+value NOUN B-O
+, PUNCT B-O
+or CCONJ B-O
+95 NUM B-O
+% NOUN B-O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT B-O
+CI PROPN B-AC
+) PUNCT B-O
+were AUX B-O
+directly ADV B-O
+given VERB B-O
+in ADP B-O
+the DET B-O
+literature NOUN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+4 X B-O
+) PUNCT B-O
+The DET B-O
+language NOUN B-O
+of ADP B-O
+the DET B-O
+literature NOUN B-O
+was AUX B-O
+Chinese PROPN B-O
+or CCONJ B-O
+English PROPN B-O
+. PUNCT B-O
+
+( PUNCT B-O
+5 X B-O
+) PUNCT B-O
+For ADP B-O
+multiple ADJ B-O
+studies NOUN B-O
+of ADP B-O
+the DET B-O
+same ADJ B-O
+author NOUN B-O
+, PUNCT B-O
+the DET B-O
+latest ADJ B-O
+study NOUN B-O
+or CCONJ B-O
+that SCONJ B-O
+with ADP B-O
+sufficient ADJ B-O
+data NOUN B-O
+was AUX B-O
+selected VERB B-O
+. PUNCT B-O
+
+The DET B-O
+median ADJ B-O
+age NOUN B-O
+was AUX B-O
+45 NUM B-O
+years NOUN B-O
+( PUNCT B-O
+interquartile ADJ B-LF
+range NOUN I-LF
+( PUNCT B-O
+IQR PROPN B-AC
+) PUNCT B-O
+38–54 NUM B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+MACEs PROPN B-AC
+: PUNCT B-O
+major ADJ B-LF
+adverse ADJ I-LF
+cardiac ADJ I-LF
+events NOUN I-LF
+, PUNCT B-O
+MI PROPN B-O
+: PUNCT B-O
+myocardial ADJ B-O
+infarction NOUN B-O
+, PUNCT B-O
+TLR NOUN B-O
+: PUNCT B-O
+target NOUN B-O
+lesion NOUN B-O
+revascularization NOUN B-O
+, PUNCT B-O
+TVR NOUN B-O
+: PUNCT B-O
+target NOUN B-O
+vessel NOUN B-O
+revascularization NOUN B-O
+, PUNCT B-O
+ST NOUN B-O
+: PUNCT B-O
+stent NOUN B-O
+thrombosis NOUN B-O
+. PUNCT B-O
+
+Abbreviations NOUN B-O
+: PUNCT B-O
+ER PROPN B-AC
+, PUNCT B-O
+estrogen NOUN B-LF
+receptor NOUN I-LF
+; PUNCT B-O
+PR PROPN B-AC
+, PUNCT B-O
+progesterone NOUN B-LF
+receptor NOUN I-LF
+; PUNCT B-O
+HER2 PROPN B-O
+, PUNCT B-O
+Human PROPN B-O
+epidermal ADJ B-O
+growth NOUN B-O
+factor NOUN B-O
+receptor NOUN B-O
+2 NUM B-O
+; PUNCT B-O
+FSH PROPN B-O
+, PUNCT B-O
+follicle NOUN B-O
+stimulating VERB B-O
+hormone NOUN B-O
+; PUNCT B-O
+AST PROPN B-AC
+, PUNCT B-O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+; PUNCT B-O
+ALT PROPN B-AC
+, PUNCT B-O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+; PUNCT B-O
+HDL PROPN B-O
+, PUNCT B-O
+high ADJ B-O
+- PUNCT B-O
+density NOUN B-O
+lipoprotein NOUN B-O
+; PUNCT B-O
+LDL NOUN B-O
+, PUNCT B-O
+low ADJ B-O
+- PUNCT B-O
+density NOUN B-O
+lipoprotein NOUN B-O
+; PUNCT B-O
+NFS PROPN B-O
+, PUNCT B-O
+nonalcoholic ADJ B-O
+fatty ADJ B-O
+liver NOUN B-O
+disease NOUN B-O
+fibrosis NOUN B-O
+score NOUN B-O
+; PUNCT B-O
+FIB-4 NOUN B-O
+, PUNCT B-O
+fibrosis-4 NOUN B-O
+; PUNCT B-O
+CT PROPN B-AC
+, PUNCT B-O
+computed VERB B-LF
+tomography NOUN I-LF
+. PUNCT B-O
+
+Worldwide ADV B-O
+, PUNCT B-O
+HPVs PROPN B-AC
+are AUX B-O
+known VERB B-O
+to PART B-O
+be AUX B-O
+one NUM B-O
+of ADP B-O
+the DET B-O
+most ADV B-O
+common ADJ B-O
+Sexually ADV B-LF
+Transmitted VERB I-LF
+Infections NOUN I-LF
+( PUNCT B-O
+STIs PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+Diet NOUN B-O
+was AUX B-O
+assessed VERB B-O
+using VERB B-O
+the DET B-O
+FAST PROPN B-AC
+( PUNCT B-O
+Food PROPN B-LF
+Assessment PROPN I-LF
+in ADP I-LF
+Schools PROPN I-LF
+Tool PROPN I-LF
+) PUNCT B-O
+food NOUN B-O
+diary NOUN B-O
+method NOUN B-O
+, PUNCT B-O
+a DET B-O
+method NOUN B-O
+validated VERB B-O
+for ADP B-O
+use NOUN B-O
+in ADP B-O
+young ADJ B-O
+children NOUN B-O
+[ PUNCT B-O
+14 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+BMI PROPN B-AC
+was AUX B-O
+also ADV B-O
+determined VERB B-O
+according VERB B-O
+to PART B-O
+the DET B-O
+International PROPN B-O
+Obesity PROPN B-O
+Task PROPN B-O
+Force PROPN B-O
+( PUNCT B-O
+IOTF PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT B-O
+WHO PROPN B-AC
+) PUNCT B-O
+criteria NOUN B-O
+: PUNCT B-O
+Thin ADJ B-O
+< NUM B-O
+5th ADJ B-O
+centiles NOUN B-O
+; PUNCT B-O
+normal ADJ B-O
+5th ADJ B-O
+to PART B-O
+< NUM B-O
+85th ADJ B-O
+centiles NOUN B-O
+; PUNCT B-O
+overweight ADJ B-O
+85th ADJ B-O
+to PART B-O
+< NUM B-O
+95th ADJ B-O
+centiles NOUN B-O
+; PUNCT B-O
+obese ADJ B-O
+95th ADJ B-O
+to PART B-O
+< NUM B-O
+98th ADJ B-O
+centiles NOUN B-O
+; PUNCT B-O
+and CCONJ B-O
+extremely ADV B-O
+- ADJ B-O
+obese ADJ B-O
+≥98th ADJ B-O
+centiles NOUN B-O
+[ PUNCT B-O
+13 NUM B-O
+] PUNCT B-O
+. PUNCT B-O
+
+ECRL PROPN B-O
+, PUNCT B-O
+extensor NOUN B-O
+carpi X B-O
+radialis X B-O
+longus X B-O
+; PUNCT B-O
+EEG PROPN B-AC
+, PUNCT B-O
+electroencephalography NOUN B-LF
+; PUNCT B-O
+EMG PROPN B-AC
+, PUNCT B-O
+electromyography NOUN B-LF
+. PUNCT B-O
+
+Plasma NOUN B-O
+interleukin-6 NOUN B-LF
+( PUNCT B-O
+IL-6 PROPN B-AC
+) PUNCT B-O
+levels NOUN B-O
+were AUX B-O
+quantitated VERB B-O
+using VERB B-O
+the DET B-O
+MILLIPLEX PROPN B-O
+® PROPN B-O
+MAP PROPN B-O
+Human PROPN B-O
+High ADJ B-O
+Sensitivity PROPN B-O
+T PROPN B-O
+Cell PROPN B-O
+Magnetic PROPN B-O
+Bead PROPN B-O
+Panel PROPN B-O
+immunoassay NOUN B-O
+( PUNCT B-O
+Merck PROPN B-O
+KGaA PROPN B-O
+, PUNCT B-O
+Darmstadt PROPN B-O
+, PUNCT B-O
+Germany PROPN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+After ADP B-O
+staining VERB B-O
+polytene NOUN B-O
+chromosomes NOUN B-O
+from ADP B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+larvae NOUN B-O
+with ADP B-O
+antibodies NOUN B-O
+against ADP B-O
+ISWI PROPN B-AC
+and CCONJ B-O
+the DET B-O
+elongating VERB B-O
+form NOUN B-O
+of ADP B-O
+Pol PROPN B-AC
+( PUNCT B-O
+Pol PROPN B-O
+IIoser2 PROPN B-O
+) PUNCT B-O
+, PUNCT B-O
+the DET B-O
+positions NOUN B-O
+of ADP B-O
+potential ADJ B-O
+target NOUN B-O
+genes NOUN B-O
+were AUX B-O
+identified VERB B-O
+by ADP B-O
+fluorescent ADJ B-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+( PUNCT B-O
+IIFISH PROPN B-AC
+; PUNCT B-O
+Figure PROPN B-O
+3C NUM B-O
+and CCONJ B-O
+3D NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+For ADP B-O
+these DET B-O
+experiments NOUN B-O
+, PUNCT B-O
+we PRON B-O
+selected VERB B-O
+genes NOUN B-O
+that PRON B-O
+exhibited VERB B-O
+at ADP B-O
+least ADJ B-O
+a DET B-O
+2.5 ADJ B-O
+- PUNCT B-O
+fold ADJ B-O
+change NOUN B-O
+in ADP B-O
+gene NOUN B-O
+expression NOUN B-O
+in ADP B-O
+Iswi PROPN B-O
+mutant ADJ B-O
+versus ADP B-O
+wild ADJ B-O
+- PUNCT B-O
+type NOUN B-O
+male NOUN B-O
+larvae NOUN B-O
+. PUNCT B-O
+
+This PRON B-O
+resulted VERB B-O
+in ADP B-O
+excluding VERB B-O
+an DET B-O
+average ADJ B-O
+number NOUN B-O
+of ADP B-O
+voxels NOUN B-O
+equal ADJ B-O
+to ADP B-O
+16.2 NUM B-O
+% NOUN B-O
+of ADP B-O
+the DET B-O
+region NOUN B-LF
+EVC PROPN B-AC
+of ADP I-LF
+interest NOUN I-LF
+( PUNCT B-O
+ROI PROPN B-AC
+; PUNCT B-O
+range NOUN B-O
+7.23%–31.55 NUM B-O
+% NOUN B-O
+across ADP B-O
+participants NOUN B-O
+) PUNCT B-O
+. PUNCT B-O
+
+Tissue NOUN B-O
+advanced ADJ B-LF
+glycation NOUN I-LF
+end NOUN I-LF
+product NOUN I-LF
+( PUNCT B-O
+AGE PROPN B-AC
+) PUNCT B-O
+accumulation NOUN B-O
+has AUX B-O
+been AUX B-O
+proposed VERB B-O
+as ADP B-O
+a DET B-O
+marker NOUN B-O
+of ADP B-O
+cumulative ADJ B-O
+metabolic ADJ B-O
+stress NOUN B-O
+that PRON B-O
+can AUX B-O
+be AUX B-O
+assessed VERB B-O
+noninvasively ADV B-O
+by ADP B-O
+measurement NOUN B-O
+of ADP B-O
+skin NOUN B-LF
+autofluorescence NOUN I-LF
+( PUNCT B-O
+SAF PROPN B-AC
+) PUNCT B-O
+. PUNCT B-O
+
+In ADP B-O
+persons NOUN B-O
+on ADP B-O
+haemodialysis NOUN B-O
+, PUNCT B-O
+SAF PROPN B-AC
+is AUX B-O
+an DET B-O
+independent ADJ B-O
+risk NOUN B-O
+factor NOUN B-O
+for ADP B-O
+cardiovascular ADJ B-LF
+events NOUN I-LF
+( PUNCT B-O
+CVEs PROPN B-AC
+) PUNCT B-O
+and CCONJ B-O
+all DET B-LF
+- PUNCT I-LF
+cause NOUN I-LF
+mortality NOUN I-LF
+( PUNCT B-O
+ACM PROPN B-AC
+) PUNCT B-O
+, PUNCT B-O
+but CCONJ B-O
+data NOUN B-O
+at ADP B-O
+earlier ADJ B-O
+stages NOUN B-O
+of ADP B-O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT B-O
+CKD PROPN B-AC
+) PUNCT B-O
+are AUX B-O
+inconclusive ADJ B-O
+. PUNCT B-O
+
+If SCONJ B-O
+the DET B-O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+SBP PROPN B-AC
+) PUNCT B-O
+or CCONJ B-O
+diastolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+( PUNCT B-O
+DBP PROPN B-AC
+) PUNCT B-O
+exceeded VERB B-O
+140 NUM B-O
+mmHg NOUN B-O
+or CCONJ B-O
+90 NUM B-O
+mmHg NOUN B-O
+, PUNCT B-O
+respectively ADV B-O
+, PUNCT B-O
+the DET B-O
+measurement NOUN B-O
+was AUX B-O
+repeated VERB B-O
+after ADP B-O
+5 NUM B-O
+min NOUN B-O
+, PUNCT B-O
+and CCONJ B-O
+the DET B-O
+results NOUN B-O
+were AUX B-O
+averaged VERB B-O
+. PUNCT B-O
+
+The DET B-O
+largest ADJ B-O
+cluster NOUN B-O
+( PUNCT B-O
+# PUNCT B-O
+0 NUM B-O
+) PUNCT B-O
+has VERB B-O
+16 NUM B-O
+members NOUN B-O
+, PUNCT B-O
+a DET B-O
+silhouette NOUN B-O
+value NOUN B-O
+of ADP B-O
+0.789 NUM B-O
+and CCONJ B-O
+is AUX B-O
+labeled VERB B-O
+as ADP B-O
+carcinogenic ADJ B-O
+aristolochic ADJ B-O
+acid NOUN B-O
+by ADP B-O
+LLR PROPN B-AC
+( PUNCT B-O
+log ADJ B-LF
+- PUNCT I-LF
+likelihood NOUN I-LF
+ratio NOUN I-LF
+) PUNCT B-O
+. PUNCT B-O
+
+As SCONJ B-O
+shown VERB B-O
+in ADP B-O
+Figure NOUN B-O
+1B NUM B-O
+, PUNCT B-O
+quantitative ADJ B-O
+PCR NOUN B-O
+experiments NOUN B-O
+demonstrated VERB B-O
+that SCONJ B-O
+β PUNCT B-O