diff --git "a/data/train.conll" "b/data/train.conll" deleted file mode 100644--- "a/data/train.conll" +++ /dev/null @@ -1,41071 +0,0 @@ -For ADP B-O -this DET B-O -purpose NOUN B-O -the DET B-O -Gothenburg PROPN B-LF -Young PROPN I-LF -Persons PROPN I-LF -Empowerment PROPN I-LF -Scale PROPN I-LF -( PUNCT B-O -GYPES PROPN B-AC -) PUNCT B-O -was AUX B-O -developed VERB B-O -. PUNCT B-O - -The DET B-O -following ADJ B-O -physiological ADJ B-O -traits NOUN B-O -were AUX B-O -measured VERB B-O -: PUNCT B-O -stomatal ADJ B-LF -conductance NOUN I-LF -( PUNCT B-O -gs PROPN B-AC -, PUNCT B-O -mol NOUN B-O -H2O NOUN B-O -m-2 NOUN B-O -s-1 NOUN B-O -) PUNCT B-O -, PUNCT B-O -transpiration NOUN B-LF -rate NOUN I-LF -( PUNCT B-O -E PROPN B-AC -, PUNCT B-O -mmol NOUN B-O -H2O NOUN B-O -m-2 NOUN B-O -s-1 NOUN B-O -) PUNCT B-O -, PUNCT B-O -net ADJ B-LF -photosynthetic ADJ I-LF -rate NOUN I-LF -( PUNCT B-O -PN PROPN B-AC -, PUNCT B-O -μmol NOUN B-O -m-2 NOUN B-O -s-1 NOUN B-O -) PUNCT B-O -and CCONJ B-O -intercellular ADJ B-LF -CO2 NOUN I-LF -concentration NOUN I-LF -CO2 PROPN B-AC -( PUNCT B-O -Ci PROPN B-AC -, PUNCT B-O -μmol NOUN B-O -m-2 NOUN B-O -s-1 NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Minor ADJ B-O -H PROPN B-AC -antigen NOUN B-O -alloimmune ADJ B-O -responses NOUN B-O -readily ADV B-O -occur VERB B-O -in ADP B-O -the DET B-O -setting NOUN B-O -of ADP B-O -human ADJ B-LF -leukocyte NOUN I-LF -antigen NOUN I-LF -( PUNCT B-O -HLA)–matched PROPN B-AC -allogeneic ADJ B-O -solid ADJ B-O -organ NOUN B-O -and CCONJ B-O -stem NOUN B-LF -cell NOUN I-LF -transplantation NOUN I-LF -( PUNCT B-O -SCT PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -3,4 NUM B-O -] PUNCT B-O -. PUNCT B-O - -EPI PROPN B-AC -= PUNCT B-O -Echo NOUN B-LF -planar NOUN I-LF -imaging NOUN I-LF -. PUNCT B-O - -Furthermore ADV B-O -, PUNCT B-O -eNOS PROPN B-AC -- PUNCT B-O -derived VERB B-O -NO PROPN B-AC -S NOUN B-O -- PUNCT B-O -nitrosylated VERB B-O -β PUNCT B-O -- PUNCT B-O -actin NOUN B-O -on ADP B-O -Cys374 PROPN B-O -and CCONJ B-O -impaired VERB B-O -actin NOUN B-O -binding VERB B-O -to ADP B-O -profilin-1 NOUN B-LF -( PUNCT B-O -PFN1 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -as SCONJ B-O -confirmed VERB B-O -with ADP B-O -the DET B-O -transnitrosylating NOUN B-O -agent NOUN B-O -S NOUN B-LF -- PUNCT I-LF -nitroso NOUN I-LF -- PUNCT I-LF -L NOUN I-LF -- PUNCT I-LF -cysteine NOUN I-LF -( PUNCT B-O -Cys-NO PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The PROPN B-AC -importance NOUN B-O -of ADP B-O -NO PROPN B-AC -and CCONJ B-O -the DET B-O -formation NOUN B-O -of ADP B-O -PFN1 PROPN B-AC -- PUNCT B-O -actin NOUN B-O -complexes NOUN B-O -on ADP B-O -the DET B-O -regulation NOUN B-O -of ADP B-O -PKC PROPN B-AC -was AUX B-O -corroborated VERB B-O -by ADP B-O -overexpression NOUN B-O -of ADP B-O --θPFN1- PROPN B-AC -and CCONJ B-O -actin NOUN B-O -- PUNCT B-O -binding VERB B-O -defective ADJ B-O -mutants NOUN B-O -of ADP B-O -β PUNCT B-O -- PUNCT B-O -actin NOUN B-O -( PUNCT B-O -C374S PROPN B-O -) PUNCT B-O -and CCONJ B-O -PFN1 PROPN B-AC -( PUNCT B-O -H119E PROPN B-O -) PUNCT B-O -, PUNCT B-O -respectively ADV B-O -, PUNCT B-O -which PRON B-O -reduced VERB B-O -the DET B-O -coalescence NOUN B-O -of ADP B-O -PKC PROPN B-AC -at ADP B-O -the DET B-O --θc-SMAC PROPN B-AC -. PUNCT B-O - -These DET B-O -findings NOUN B-O -unveil VERB B-O -a DET B-O -novel ADJ B-O -NO PROPN B-AC -- PUNCT B-O -dependent ADJ B-O -mechanism NOUN B-O -by ADP B-O -which PRON B-O -the DET B-O -actin NOUN B-O -cytoskeleton NOUN B-O -controls VERB B-O -the DET B-O -organization NOUN B-O -and CCONJ B-O -activation NOUN B-O -of ADP B-O -signaling NOUN B-O -microclusters NOUN B-O -at ADP B-O -the DET B-O -IS PROPN B-AC -. PUNCT B-O - -Both DET B-O -Mekk3 PROPN B-O -cKO PROPN B-AC -and CCONJ B-O -their PRON B-O -wild ADJ B-LF -- PUNCT I-LF -type NOUN I-LF -( PUNCT B-O -WT PROPN B-AC -) PUNCT B-O -littermates NOUN B-O -were AUX B-O -labeled VERB B-O -at ADP B-O -E16.5 NUM B-O -with ADP B-O -5 NUM B-LF -- PUNCT I-LF -bromo-2’-deoxyuridine NOUN I-LF -( PUNCT B-O -BrdU PROPN B-AC -) PUNCT B-O -to PART B-O -track VERB B-O -cells NOUN B-O -undergoing VERB B-O -DNA NOUN B-O -synthesis NOUN B-O -. PUNCT B-O - -Recent ADJ B-O -work NOUN B-O -by ADP B-O -us PRON B-O -and CCONJ B-O -others NOUN B-O -suggests VERB B-O -that SCONJ B-O -the DET B-O -host NOUN B-O -’s PART B-O -heat NOUN B-LF -shock NOUN I-LF -protein NOUN I-LF -90 NUM I-LF -( PUNCT B-O -Hsp90 PROPN B-AC -) PUNCT B-O -chaperone NOUN B-O -can AUX B-O -modulate VERB B-O -the DET B-O -evolutionary ADJ B-O -paths NOUN B-O -traversed VERB B-O -by ADP B-O -viruses NOUN B-O -[ PUNCT B-O -18 NUM B-O -, PUNCT B-O -19 NUM B-O -] PUNCT B-O -. PUNCT B-O - -We PRON B-O -performed VERB B-O -a DET B-O -linear ADJ B-O -regression NOUN B-O -model NOUN B-O -of ADP B-O -the DET B-O -effect NOUN B-O -of ADP B-O -PCL PROPN B-AC -on ADP B-O -Dizziness PROPN B-LF -Handicap PROPN I-LF -Inventory PROPN I-LF -( PUNCT B-O -DHI PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -DHI PROPN B-AC -was AUX B-O -significantly ADV B-O -correlated VERB B-O -to ADP B-O -PCL PROPN B-AC -scores NOUN B-O -, PUNCT B-O -suggesting VERB B-O -that SCONJ B-O -Veterans NOUN B-O -with ADP B-O -more ADJ B-O -severe ADJ B-O -PTSD PROPN B-AC -symptoms NOUN B-O -also ADV B-O -had VERB B-O -more ADJ B-O -dizziness NOUN B-O -handicap NOUN B-O -as SCONJ B-O -illustrated VERB B-O -in ADP B-O -Fig NUM B-O -2 NUM B-O -( PUNCT B-O -r2 NOUN B-O -= SYM B-O -0.28 NUM B-O -, PUNCT B-O -p NOUN B-O -< SYM B-O -0.0001 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Correlation NOUN B-O -of ADP B-O -( PUNCT B-O -a X B-O -) PUNCT B-O -rate NOUN B-O -of ADP B-O -seed NOUN B-O -mass NOUN B-O -evolution NOUN B-O -and CCONJ B-O -( PUNCT B-O -b X B-O -) PUNCT B-O -seed NOUN B-O -mass NOUN B-O -with ADP B-O -speciation NOUN B-O -rate NOUN B-O -( PUNCT B-O -λ PUNCT B-O -) PUNCT B-O -estimated VERB B-O -by ADP B-O -using VERB B-O -R PROPN B-LF -: PUNCT I-LF -Phylogenetic PROPN I-LF -ANalyses PROPN I-LF -of ADP I-LF -DiversificAtion PROPN I-LF -( PUNCT B-O -RPANDA PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -clade NOUN B-O -- PUNCT B-O -based VERB B-O -analysis NOUN B-O -. PUNCT B-O - -Typically ADV B-O -, PUNCT B-O -at ADP B-O -low ADJ B-O -inspiratory ADJ B-LF -positive ADJ I-LF -airway NOUN I-LF -pressure NOUN I-LF -( PUNCT B-O -IPAP PROPN B-AC -) PUNCT B-O -values NOUN B-O -, PUNCT B-O -short ADJ B-O -PLBD PROPN B-AC -and CCONJ B-O -low ADJ B-O -PLBP PROPN B-AC -are AUX B-O -set VERB B-O -, PUNCT B-O -at ADP B-O -higher ADJ B-O -IPAP PROPN B-AC -values NOUN B-O -, PUNCT B-O -longer ADJ B-O -PLBD PROPN B-AC -and CCONJ B-O -higher ADJ B-O -PLBP PROPN B-AC -are AUX B-O -set VERB B-O -. PUNCT B-O - -When SCONJ B-O -considering VERB B-O -the DET B-O -appropriateness NOUN B-O -of ADP B-O -introducing VERB B-O -an DET B-O -ACP PROPN B-AC -protocol NOUN B-O -at ADP B-O -KCMC PROPN B-AC -, PUNCT B-O -it PRON B-O -was AUX B-O -evident ADJ B-O -that SCONJ B-O -there PRON B-O -was AUX B-O -a DET B-O -literature NOUN B-O -deficit NOUN B-O -on ADP B-O -the DET B-O -cultural ADJ B-O -views NOUN B-O -of ADP B-O -quality NOUN B-LF -of ADP I-LF -death NOUN I-LF -( PUNCT B-O -QoD PROPN B-AC -) PUNCT B-O -in ADP B-O -Tanzania PROPN B-O -but CCONJ B-O -two NUM B-O -previous ADJ B-O -studies NOUN B-O -from ADP B-O -northern ADJ B-O -Tanzania PROPN B-O -had AUX B-O -indicated VERB B-O -that SCONJ B-O -QoD PROPN B-AC -was AUX B-O -an DET B-O -existing VERB B-O -concept NOUN B-O -in ADP B-O -northern ADJ B-O -Tanzania PROPN B-O -. PUNCT B-O - -Positive ADJ B-O -cells NOUN B-O -from ADP B-O -each DET B-O -specimen NOUN B-O -were AUX B-O -counted VERB B-O -from ADP B-O -a DET B-O -minimum NOUN B-O -of ADP B-O -four NUM B-O -randomly ADV B-O -selected VERB B-O -fields NOUN B-O -per ADP B-O -high ADJ B-LF -power NOUN I-LF -field NOUN I-LF -( PUNCT B-O -HPF PROPN B-AC -) PUNCT B-O -and CCONJ B-O -compared VERB B-O -with ADP B-O -the DET B-O -control NOUN B-O -by ADP B-O -calculating VERB B-O -the DET B-O -average ADJ B-O -number NOUN B-O -of ADP B-O -cells NOUN B-O -. PUNCT B-O - -FSC PROPN B-O -, PUNCT B-O -Fourier PROPN B-O -Shell PROPN B-O -Correlation PROPN B-O -; PUNCT B-O -MrNV PROPN B-AC -, PUNCT B-O -M. PROPN B-O -rosenbergii PROPN B-O -nodavirus NOUN B-O -; PUNCT B-O -3D PROPN B-AC -, PUNCT B-O -three NUM B-LF -- PUNCT I-LF -dimensional ADJ I-LF -. PUNCT B-O - -In ADP B-O -rodent ADJ B-O -taste NOUN B-O -cells NOUN B-O -, PUNCT B-O -expression NOUN B-O -of ADP B-O -insulin NOUN B-O -and CCONJ B-O -the DET B-O -insulin NOUN B-LF -receptor NOUN I-LF -subunit NOUN I-LF -α PUNCT I-LF -( PUNCT B-O -IRα PROPN B-AC -) PUNCT B-O -has AUX B-O -been AUX B-O -proposed VERB B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -, PUNCT B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -To PART B-O -test VERB B-O -this PRON B-O -, PUNCT B-O -we PRON B-O -exposed VERB B-O -the DET B-O -mouse NOUN B-O -intestine NOUN B-O -to ADP B-O -two NUM B-O -conditions NOUN B-O -: PUNCT B-O -1 X B-O -) PUNCT B-O -30 NUM B-O -min NOUN B-O -of ADP B-O -ischemia NOUN B-O -followed VERB B-O -by ADP B-O -30 NUM B-O -min NOUN B-O -of ADP B-O -reperfusion NOUN B-O -stress NOUN B-O -, PUNCT B-O -and CCONJ B-O -2 X B-O -) PUNCT B-O -ischemia NOUN B-LF -/ SYM I-LF -reperfusion NOUN I-LF -( PUNCT B-O -I/R PROPN B-AC -) PUNCT B-O -stress NOUN B-O -coupled VERB B-O -with ADP B-O -luminal ADJ B-O -inoculation NOUN B-O -with ADP B-O -P. NOUN B-O -aeruginosa NOUN B-O -( PUNCT B-O -I PROPN B-AC -+ CCONJ B-O -Pa PROPN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -localization NOUN B-O -of ADP B-O -motility NOUN B-O -complexes NOUN B-O -, PUNCT B-O -and CCONJ B-O -thereby ADV B-O -the DET B-O -direction NOUN B-O -of ADP B-O -movement NOUN B-O -, PUNCT B-O -is AUX B-O -determined VERB B-O -by ADP B-O -an DET B-O -oscillatory ADJ B-O -system NOUN B-O -, PUNCT B-O -which PRON B-O -includes VERB B-O -Mutual PROPN B-LF -gliding NOUN I-LF -motility NOUN I-LF -A NOUN I-LF -( PUNCT B-O -MglA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -small ADJ B-O -Ras PROPN B-O -- PUNCT B-O -like ADJ B-O -GTPase NOUN B-O -, PUNCT B-O -and CCONJ B-O -Mutual PROPN B-LF -gliding NOUN I-LF -motility NOUN I-LF -B NOUN I-LF -( PUNCT B-O -MglB PROPN B-AC -) PUNCT B-O -, PUNCT B-O -its PRON B-O -GTPase NOUN B-LF -activating VERB I-LF -protein NOUN I-LF -( PUNCT B-O -GAP PROPN B-AC -) PUNCT B-O -as ADP B-O -major ADJ B-O -components NOUN B-O -[ X B-O -1,4,5 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Using VERB B-O -chemical NOUN B-O -cross NOUN B-O -- PUNCT B-O -linking NOUN B-O -/ SYM B-O -MS PROPN B-AC -, PUNCT B-O -we PRON B-O -had AUX B-O -been AUX B-O -able ADJ B-O -to PART B-O -monitor VERB B-O -conformational ADJ B-O -changes NOUN B-O -in ADP B-O -the DET B-O -ligand NOUN B-LF -- PUNCT I-LF -binding VERB I-LF -domain NOUN I-LF -( PUNCT B-O -LBD PROPN B-AC -) PUNCT B-O -of ADP B-O -PPAR PROPN B-AC -- PUNCT B-O -α PUNCT B-O -upon SCONJ B-O -ligand NOUN B-O -binding.[8 NOUN B-O -] PUNCT B-O -Inbred ADJ B-O -line NOUN B-O -L8 PROPN B-O -was AUX B-O -about ADV B-O -the DET B-O -most ADV B-O -distant ADJ B-O -line NOUN B-O -to ADP B-O -the DET B-O -three NUM B-O -testers NOUN B-O -based VERB B-O -on ADP B-O -both DET B-O -GDs PROPN B-AC -. PUNCT B-O - -As SCONJ B-O -shown VERB B-O -in ADP B-O -Fig NOUN B-O -1 NUM B-O -, PUNCT B-O -the DET B-O -genetic ADJ B-LF -distance NOUN I-LF -estimates NOUN B-O -between ADP B-O -the DET B-O -Striga PROPN B-O -resistant ADJ B-O -lines NOUN B-O -and CCONJ B-O -the DET B-O -resistant ADJ B-O -tester NOUN B-O -were AUX B-O -broader ADJ B-O -in ADP B-O -the DET B-O -range NOUN B-O -of ADP B-O -GD PROPN B-AC -values NOUN B-O -than ADP B-O -those PRON B-O -between ADP B-O -the DET B-O -Striga PROPN B-O -- PUNCT B-O -resistant ADJ B-O -and CCONJ B-O -susceptible ADJ B-O -tester NOUN B-O -, PUNCT B-O -indicating VERB B-O -the DET B-O -resistant ADJ B-O -tester NOUN B-O -was AUX B-O -considered VERB B-O -as ADP B-O -a DET B-O -suitable ADJ B-O -tester NOUN B-O -. PUNCT B-O - -Cardiac ADJ B-O -inflammation NOUN B-O -induced VERB B-O -by ADP B-O -B. PROPN B-O -burgdorferi PROPN B-O -is AUX B-O -dependent ADJ B-O -on ADP B-O -the DET B-O -interaction NOUN B-O -of ADP B-O -the DET B-O -spirochete NOUN B-O -with ADP B-O -macrophages NOUN B-O -and CCONJ B-O -other ADJ B-O -cell NOUN B-O -types NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -invariant ADJ B-LF -NKT NOUN I-LF -( PUNCT B-O -iNKT PROPN B-AC -) PUNCT B-O -or CCONJ B-O -T NOUN B-O -cells NOUN B-O -[ PUNCT B-O -35 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -are AUX B-O -expressed VERB B-O -as ADP B-O -mean NOUN B-O -± ADP B-O -SEM PROPN B-AC -, PUNCT B-O -n NOUN B-O -= SYM B-O -3 NUM B-O -from ADP B-O -at ADV B-O -least ADV B-O -three NUM B-O -independent ADJ B-O -experiments NOUN B-O -; PUNCT B-O -nd PROPN B-AC -: PUNCT B-O -not PART B-LF -detected VERB I-LF -or CCONJ B-O -below ADP B-O -the DET B-O -limit NOUN B-O -of ADP B-O -quantitation NOUN B-O -. PUNCT B-O - -BMI NOUN B-O -: PUNCT B-O -body NOUN B-O -mass NOUN B-O -index NOUN B-O -; PUNCT B-O -CE PROPN B-AC -: PUNCT B-O -cholesteryl ADJ B-O -ester NOUN B-O -; PUNCT B-O -ELF PROPN B-AC -: PUNCT B-O -epithelial ADJ B-LF -lining NOUN I-LF -fluid NOUN I-LF -; PUNCT B-O -FEV1 PROPN B-AC -: PUNCT B-O -forced VERB B-LF -expiratory ADJ I-LF -volume NOUN I-LF -in ADP I-LF -1 NUM I-LF -second NOUN I-LF -; PUNCT B-O -FVC PROPN B-AC -: PUNCT B-O -forced VERB B-LF -vital ADJ I-LF -capacity NOUN I-LF -; PUNCT B-O -IL PROPN B-O -: PUNCT B-O -Interleukin NOUN B-O -; PUNCT B-O -LABA PROPN B-O -: PUNCT B-O -long VERB B-O -acting VERB B-O -beta NOUN B-O -agonists NOUN B-O -; PUNCT B-O -LAMA PROPN B-O -: PUNCT B-O -long VERB B-O -acting VERB B-O -muscarinic ADJ B-O -antagonists NOUN B-O -; PUNCT B-O -MCP-1 NOUN B-O -: PUNCT B-O -macrophage NOUN B-O -chemotactic ADJ B-O -protein-1 NOUN B-O -; PUNCT B-O -TG PROPN B-AC -: PUNCT B-O -triglyceride NOUN B-O -. PUNCT B-O - -DEFF PROPN B-AC -: PUNCT B-O -Design NOUN B-LF -effect NOUN I-LF -; PUNCT B-O -ICC PROPN B-AC -: PUNCT B-O -Intracluster ADJ B-LF -correlation NOUN I-LF -coefficient NOUN I-LF -; PUNCT B-O -SD PROPN B-AC -: PUNCT B-O -Standard ADJ B-LF -deviation NOUN I-LF -; PUNCT B-O -IQR PROPN B-AC -: PUNCT B-O -Interquartile ADJ B-LF -range NOUN I-LF -. PUNCT B-O - -The DET B-O -leading VERB B-O -causes NOUN B-O -of ADP B-O -death NOUN B-O -and CCONJ B-O -morbidity NOUN B-O -worldwide ADV B-O -are AUX B-O -noncommunicable ADJ B-LF -diseases NOUN I-LF -( PUNCT B-O -NCDs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -chronic ADJ B-O -respiratory ADJ B-O -disease NOUN B-O -, PUNCT B-O -cancer NOUN B-O -, PUNCT B-O -diabetes NOUN B-O -, PUNCT B-O -and CCONJ B-O -, PUNCT B-O -in ADP B-O -particular ADJ B-O -, PUNCT B-O -ischemic ADJ B-O -heart NOUN B-O -disease NOUN B-O -and CCONJ B-O -stroke NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -slope NOUN B-O -of ADP B-O -field NOUN B-LF -excitatory ADJ I-LF -postsynaptic ADJ I-LF -potentials NOUN I-LF -( PUNCT B-O -fEPSPs PROPN B-AC -) PUNCT B-O -( PUNCT B-O -Fig NOUN B-O -6B NUM B-O -) PUNCT B-O -was AUX B-O -measured VERB B-O -to PART B-O -monitor VERB B-O -synaptic ADJ B-O -activation NOUN B-O -of ADP B-O -the DET B-O -CA1 NOUN B-O -pyramidal ADJ B-O -neurons NOUN B-O -. PUNCT B-O - -BAZ PROPN B-AC -, PUNCT B-O -BMI NOUN B-LF -- PUNCT I-LF -BMI PROPN B-AC -for ADP I-LF -- PUNCT I-LF -age NOUN I-LF -z- NOUN B-O -score NOUN B-O -; PUNCT B-O -T PROPN B-AC -, PUNCT B-O -triene NOUN B-O -- PUNCT B-O -to ADP B-O -- PUNCT B-O -tetraene NOUN B-O -These DET B-O -supercomplexes NOUN B-O -are AUX B-O -associations NOUN B-O -of ADP B-O -oxidase NOUN B-O -with ADP B-O -either CCONJ B-O -respiratory ADJ B-O -complexIII PROPN B-AC -and CCONJ B-O -cytochrome NOUN B-LF -c552 NOUN I-LF -( PUNCT B-O -Sc NOUN B-O -: PUNCT B-O -III4IV2 NUM B-O -, PUNCT B-O -Sb NOUN B-O -: PUNCT B-O -III4IV4 NUM B-O -) PUNCT B-O -or CCONJ B-O -of ADP B-O -complex PROPN B-AC -, PUNCT B-O -IIIcomplexI PROPN B-AC -and CCONJ B-O -cyt PROPN B-AC -( PUNCT B-O -Sa NOUN B-O -: PUNCT B-O -I1III4IV4 NOUN B-O -; PUNCT B-O -S1 NOUN B-O -, PUNCT B-O -S3 PROPN B-O -and CCONJ B-O -S4 PROPN B-O -Figs NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -Ct PROPN B-AC -, PUNCT B-O -cycle NOUN B-LF -threshold NOUN I-LF -; PUNCT B-O -n NOUN B-O -/ SYM B-O -a NOUN B-O -, PUNCT B-O -not PART B-O -applicable ADJ B-O -; PUNCT B-O -N1 PROPN B-AC -, PUNCT B-O -SARS PROPN B-LF -- PUNCT I-LF -SARS PROPN B-AC -CoV-2 NOUN I-LF -nucleocapsid NOUN I-LF -gene NOUN I-LF -region NOUN I-LF -1 NUM I-LF -; PUNCT B-O --CoV-2SARS PROPN B-AC -, PUNCT B-O -severe ADJ B-LF -acute ADJ I-LF -respiratory ADJ I-LF -syndrome NOUN I-LF -coronavirus NOUN I-LF -2 NUM I-LF -; PUNCT B-O -Unk PROPN B-O -, PUNCT B-O -Unknown ADJ B-O -To PART B-O -further ADV B-O -identify VERB B-O -significant ADJ B-O -correlations NOUN B-O -between ADP B-O -phenotypes NOUN B-O -and CCONJ B-O -GO PROPN B-AC -concepts NOUN B-O -, PUNCT B-O -we PRON B-O -used VERB B-O -a DET B-O -GO PROPN B-AC -term NOUN B-O -finder NOUN B-O -software NOUN B-O -[ X B-O -49 X B-O -] X B-O -to ADP B-O -correlate VERB B-O -phenotypes NOUN B-O -with ADP B-O -GO PROPN B-AC -using VERB B-O -the DET B-O -Pfam PROPN B-AC -to ADP B-O -GO PROPN B-AC -mapping NOUN B-O -data NOUN B-O -from ADP B-O -the DET B-O -Gene PROPN B-LF -Ontology PROPN I-LF -Consortium PROPN B-O -. PUNCT B-O - -Crude ADJ B-LF -lipid NOUN I-LF -extract NOUN I-LF -( PUNCT B-O -CLE PROPN B-AC -in ADP B-O -mg NOUN B-O -) PUNCT B-O -was AUX B-O -estimated VERB B-O -following VERB B-O -Cointet PROPN B-O -et PROPN B-O -al PROPN B-O -. PUNCT B-O - -( PUNCT B-O -2019 NUM B-O -) PUNCT B-O -and CCONJ B-O -lipid NOUN B-O -content NOUN B-O -( PUNCT B-O -LC NOUN B-O -) PUNCT B-O -was AUX B-O -estimated VERB B-O -in ADP B-O -mg NOUN B-O -. PUNCT B-O - -L-1 NOUN B-O -. PUNCT B-O - -One NUM B-O -day NOUN B-O -after ADP B-O -the DET B-O -preparation NOUN B-O -, PUNCT B-O -slice NOUN B-O -cultures NOUN B-O -were AUX B-O -transduced VERB B-O -with ADP B-O -adeno NOUN B-LF -- NOUN I-LF -associated VERB I-LF -virus NOUN I-LF -( PUNCT B-O -AAV PROPN B-AC -) PUNCT B-O -serotype NOUN B-O -9 NUM B-O -particles NOUN B-O -encoding VERB B-O -CaMKII.iGluu NOUN B-O -. PUNCT B-O - -WPRE NOUN B-O -- NOUN B-O -hGH NOUN B-O -[ PUNCT B-O -30 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Potato NOUN B-LF -dextrose NOUN I-LF -agar NOUN I-LF -( PUNCT B-O -PDA PROPN B-AC -) PUNCT B-O -and CCONJ B-O -potato NOUN B-LF -dextrose NOUN I-LF -broth NOUN I-LF -( PUNCT B-O -PDB PROPN B-AC -) PUNCT B-O -were AUX B-O -purchased VERB B-O -from ADP B-O -Difco PROPN B-O -( PUNCT B-O -BD PROPN B-O -, PUNCT B-O -USA PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Calcium NOUN B-LF -carbonate NOUN I-LF -( PUNCT B-O -CaCO3 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -ethanol NOUN B-O -were AUX B-O -purchased VERB B-O -from ADP B-O -Systerm PROPN B-O -( PUNCT B-O -Selangor PROPN B-O -, PUNCT B-O -Malaysia PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Estimated VERB B-LF -glomerular ADJ I-LF -filtration NOUN I-LF -rates NOUN I-LF -( PUNCT B-O -eGFRs PROPN B-AC -) PUNCT B-O -were AUX B-O -calculated VERB B-O -using VERB B-O -the DET B-O -four NUM B-O -- PUNCT B-O -variable NOUN B-O -equation NOUN B-O -derived VERB B-O -from ADP B-O -the DET B-O -Modification PROPN B-LF -of ADP I-LF -Diet PROPN I-LF -in ADP I-LF -Renal PROPN I-LF -Disease PROPN I-LF -( PUNCT B-O -MDRD PROPN B-AC -) PUNCT B-O -Study PROPN B-O -. PUNCT B-O - -We PRON B-O -used VERB B-O -the DET B-O -cross ADJ B-O -- PUNCT B-O -sectional ADJ B-O -data NOUN B-O -including VERB B-O -6,160 NUM B-O -oldest ADJ B-O -old ADJ B-O -( PUNCT B-O -aged ADJ B-O -80 NUM B-O -years NOUN B-O -old ADJ B-O -or CCONJ B-O -older ADJ B-O -) PUNCT B-O -from ADP B-O -the DET B-O -genetic ADJ B-O -substudy NOUN B-O -of ADP B-O -the DET B-O -Chinese PROPN B-LF -Longitudinal PROPN I-LF -Healthy PROPN I-LF -Longevity PROPN I-LF -Survey PROPN I-LF -( PUNCT B-O -CLHLS PROPN B-AC -) PUNCT B-O -which PRON B-O -is AUX B-O -a DET B-O -national ADJ B-O -wide ADJ B-O -cohort NOUN B-O -study NOUN B-O -that PRON B-O -began VERB B-O -in ADP B-O -1998 NUM B-O -with ADP B-O -follow VERB B-O -- PUNCT B-O -up ADP B-O -surveys NOUN B-O -every DET B-O -2–3 NUM B-O -years NOUN B-O -. PUNCT B-O - -Surprisingly ADV B-O -, PUNCT B-O -although SCONJ B-O -IL-22 PROPN B-AC -activates VERB B-O -signal NOUN B-LF -transducer NOUN I-LF -and CCONJ I-LF -activator NOUN I-LF -of ADP I-LF -transcription NOUN I-LF -3 NUM I-LF -( PUNCT B-O -STAT3 PROPN B-AC -) PUNCT B-O -in ADP B-O -APC PROPN B-O -- PUNCT B-O -mutant ADJ B-O -cells NOUN B-O -, PUNCT B-O -STAT3 PROPN B-AC -target NOUN B-O -genes NOUN B-O -were AUX B-O -not PART B-O -induced VERB B-O -. PUNCT B-O - -Hh PROPN B-AC -, PUNCT B-O -hedgehog NOUN B-LF -; PUNCT B-O -NRF2 PROPN B-AC -, PUNCT B-O -nuclear ADJ B-LF -factor NOUN I-LF -- PUNCT I-LF -erythroid NOUN I-LF -2 NUM I-LF -- PUNCT I-LF -like NOUN I-LF -2 NUM I-LF -IMCD3 PROPN B-AC -, PUNCT B-O -inner ADJ B-LF -medullary NOUN I-LF -collecting VERB I-LF -duct NOUN I-LF -; PUNCT B-O -Nb PROPN B-AC -, PUNCT B-O -nanobody NOUN B-LF -; PUNCT B-O -SMO PROPN B-O -, PUNCT B-O -Smoothened VERB B-O -. PUNCT B-O - -Specifically ADV B-O -, PUNCT B-O -the DET B-O -non ADJ B-O -- ADJ B-O -HCC PROPN B-AC -participants NOUN B-O -included VERB B-O -123 NUM B-O -with ADP B-O -gastrointestinal ADJ B-O -tumour NOUN B-O -( PUNCT B-O -GIT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -73 NUM B-O -with ADP B-O -benign ADJ B-O -liver NOUN B-O -tumour NOUN B-O -( PUNCT B-O -BLT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -453 NUM B-O -with ADP B-O -liver NOUN B-O -cirrhosis NOUN B-O -, PUNCT B-O -27 NUM B-O -with ADP B-O -chronic ADJ B-LF -hepatitis NOUN I-LF -C NOUN I-LF -( PUNCT B-O -CHC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -86 NUM B-O -with ADP B-O -chronic ADJ B-LF -hepatitis NOUN I-LF -B NOUN I-LF -( PUNCT B-O -CHB PROPN B-AC -) PUNCT B-O -, PUNCT B-O -50 NUM B-O -with ADP B-O -benign ADJ B-LF -gastrointestinal ADJ I-LF -disease NOUN I-LF -( PUNCT B-O -BGID PROPN B-AC -) PUNCT B-O -and CCONJ B-O -295 NUM B-O -healthy ADJ B-O -people NOUN B-O -. PUNCT B-O - -To PART B-O -generate VERB B-O -null ADJ B-O -alleles NOUN B-O -, PUNCT B-O -we PRON B-O -sought VERB B-O -to PART B-O -create VERB B-O -mutants NOUN B-O -with ADP B-O -large ADJ B-O -fragment NOUN B-O -deletions NOUN B-O -by ADP B-O -designing VERB B-O -2 NUM B-O -single ADJ B-LF -guide NOUN I-LF -RNAs NOUN I-LF -( PUNCT B-O -sgRNAs PROPN B-AC -) PUNCT B-O -within ADP B-O -or CCONJ B-O -flanking VERB B-O -the DET B-O -stem NOUN B-O -- PUNCT B-O -loop NOUN B-O -region NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1B NUM B-O -) PUNCT B-O -. PUNCT B-O - -Using VERB B-O -PCR NOUN B-O -genotyping NOUN B-O -, PUNCT B-O -we PRON B-O -successfully ADV B-O -identified VERB B-O -plants NOUN B-O -carrying VERB B-O -mutations NOUN B-O -in ADP B-O -every DET B-O -MIR172 PROPN B-O -family NOUN B-O -member NOUN B-O -in ADP B-O -the DET B-O -T1 PROPN B-O -generation NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1B NUM B-O -; PUNCT B-O -S1 PROPN B-O -Fig PROPN B-O -) PUNCT B-O -. PUNCT B-O - -GP PROPN B-AC -, PUNCT B-O -EBOV NOUN B-LF -envelope NOUN I-LF -EBOV PROPN B-AC -glycoprotein NOUN I-LF -. PUNCT B-O - -We PRON B-O -used VERB B-O -a DET B-O -specific ADJ B-O -antibody NOUN B-O -against ADP B-O -the DET B-O -promyelocytic ADJ B-LF -leukemia NOUN I-LF -( PUNCT B-O -PML PROPN B-AC -) PUNCT B-O -protein NOUN B-O -to PART B-O -study VERB B-O -the DET B-O -fate NOUN B-O -of ADP B-O -the DET B-O -PML PROPN B-AC -nuclear ADJ B-O -bodies NOUN B-O -, PUNCT B-O -which PRON B-O -are AUX B-O -well ADV B-O -- PUNCT B-O -characterized VERB B-O -subnuclear ADJ B-O -structures NOUN B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -parallel NOUN B-O -, PUNCT B-O -the DET B-O -rate NOUN B-O -of ADP B-O -Caesarean ADJ B-LF -section NOUN I-LF -( PUNCT B-O -C-Section PROPN B-AC -) PUNCT B-O -deliveries NOUN B-O -has AUX B-O -also ADV B-O -increased VERB B-O -dramatically ADV B-O -over ADP B-O -the DET B-O -last ADJ B-O -decades NOUN B-O -. PUNCT B-O - -• PUNCT B-O -RLS PROPN B-AC -diagnosis NOUN B-O -was AUX B-O -made VERB B-O -on ADP B-O -the DET B-O -diagnostic ADJ B-O -criteria NOUN B-O -of ADP B-O -the DET B-O -International PROPN B-O -Restless PROPN B-LF -Legs PROPN I-LF -Syndrome PROPN I-LF -Study PROPN B-O -Group PROPN B-O -( PUNCT B-O -2010 NUM B-O -) PUNCT B-O -. PUNCT B-O - -IQR PROPN B-AC -: PUNCT B-O -interquartile ADJ B-LF -range NOUN I-LF -Similarly ADV B-O -, PUNCT B-O -assessment NOUN B-O -of ADP B-O -other ADJ B-O -quantitative ADJ B-O -variables NOUN B-O -is AUX B-O -essential ADJ B-O -in ADP B-O -pre- ADJ B-O -and CCONJ B-O -post ADJ B-O -- ADJ B-O -MI PROPN B-AC -conditions NOUN B-O -which PRON B-O -primarily ADV B-O -includes VERB B-O -, PUNCT B-O -plasma NOUN B-O -glucose NOUN B-O -levels NOUN B-O -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -high ADJ B-LF -density NOUN I-LF -lipid NOUN I-LF -( PUNCT B-O -HDL PROPN B-AC -) PUNCT B-O -, PUNCT B-O -low ADJ B-LF -density NOUN I-LF -lipid NOUN I-LF -( PUNCT B-O -LDL PROPN B-AC -) PUNCT B-O -and CCONJ B-O -triglycerides NOUN B-O -levels NOUN B-O -. PUNCT B-O - -Fresh ADJ B-O -IBM PROPN B-O -suspended VERB B-O -in ADP B-O -0.1 NUM B-O -% PUNCT B-O -AKRB PROPN B-AC -were AUX B-O -centrifuged VERB B-O -for ADP B-O -15 NUM B-O -min NOUN B-O -at ADP B-O -800 NUM B-O -rpm NOUN B-O -and CCONJ B-O -immediately ADV B-O -suspended VERB B-O -in ADP B-O -2ml NUM B-O -of ADP B-O -Dulbecco PROPN B-LF -'s PART I-LF -Modified PROPN I-LF -Eagle PROPN I-LF -'s PART I-LF -( PUNCT B-O -DMEM PROPN B-AC -) PUNCT B-O -+ SYM B-O -BSA0.1 NUM B-O -% PUNCT B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -Tem PROPN B-AC -effects NOUN B-O -on ADP B-O -LC3-II PROPN B-AC -levels NOUN B-O -were AUX B-O -also ADV B-O -preserved VERB B-O -in ADP B-O -5 NUM B-LF -' NOUN I-LF -adenosine NOUN I-LF -monophosphate NOUN I-LF -- PUNCT I-LF -activated VERB I-LF -protein NOUN I-LF -kinase NOUN I-LF -( PUNCT B-O -AMPK PROPN B-AC -) PUNCT B-O -α1 NUM B-O -/ SYM B-O -α2 NUM B-O -double ADJ B-O -KO PROPN B-AC -MEFs PROPN B-AC -( PUNCT B-O -S6B PROPN B-O -Fig PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Chronic ADJ B-O -HBV PROPN B-AC -infection NOUN B-O -was AUX B-O -classified VERB B-O -according VERB B-O -to ADP B-O -the DET B-O -latest ADJ B-O -European PROPN B-LF -Association PROPN I-LF -for ADP I-LF -the DET I-LF -Study PROPN I-LF -of ADP I-LF -the DET I-LF -Liver PROPN I-LF -( PUNCT B-O -EASL PROPN B-AC -) PUNCT B-O -Clinical PROPN B-LF -Practice PROPN I-LF -Guidelines PROPN I-LF -( PUNCT B-O -CPG PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -CI PROPN B-AC -, PUNCT B-O -confidence NOUN B-LF -interval NOUN I-LF -; PUNCT B-O -TBI PROPN B-AC -, PUNCT B-O -traumatic ADJ B-LF -brain NOUN I-LF -injury NOUN I-LF -. PUNCT B-O - -This DET B-O -study NOUN B-O -is AUX B-O -reported VERB B-O -as ADP B-O -per ADP B-O -the DET B-O -CONsolidated PROPN B-LF -Standards PROPN I-LF -of ADP I-LF -Reporting PROPN I-LF -Trials PROPN I-LF -( PUNCT B-O -CONSORT PROPN B-AC -) PUNCT B-O -( PUNCT B-O -S1 PROPN B-O -CONSORT PROPN B-AC -Checklist PROPN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -risk NOUN B-O -of ADP B-O -ID PROPN B-AC -increases VERB B-O -during ADP B-O -pregnancy NOUN B-O -due ADP B-O -to PART B-O -an DET B-O -increase NOUN B-O -in ADP B-O -maternal ADJ B-O -iron NOUN B-O -requirements NOUN B-O -to PART B-O -accommodate VERB B-O -the DET B-O -expansion NOUN B-O -of ADP B-O -maternal ADJ B-O -red ADJ B-LF -blood NOUN I-LF -cell NOUN I-LF -( PUNCT B-O -RBC PROPN B-AC -) PUNCT B-O -mass NOUN B-O -, PUNCT B-O -development NOUN B-O -of ADP B-O -the DET B-O -placenta NOUN B-O -and CCONJ B-O -fetus NOUN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -loss NOUN B-O -of ADP B-O -blood NOUN B-O -associated VERB B-O -with ADP B-O -labor NOUN B-O -and CCONJ B-O -delivery NOUN B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This DET B-O -study NOUN B-O -is AUX B-O -reported VERB B-O -according VERB B-O -to ADP B-O -the DET B-O -Strengthening VERB B-LF -the DET I-LF -Reporting PROPN I-LF -of ADP I-LF -Observational PROPN I-LF -Studies PROPN I-LF -in ADP I-LF -Epidemiology PROPN I-LF -( PUNCT B-O -STROBE PROPN B-AC -) PUNCT B-O -statement NOUN B-O -( PUNCT B-O -S1 PROPN B-O -STROBE PROPN B-AC -Checklist PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Schematic ADJ B-O -pressure NOUN B-O -curve NOUN B-O -of ADP B-O -a DET B-O -BiPAP PROPN B-AC -ventilation NOUN B-O -( PUNCT B-O -A NOUN B-O -) PUNCT B-O -compared VERB B-O -to ADP B-O -ventilation NOUN B-O -in ADP B-O -PLBV PROPN B-AC -mode NOUN B-O -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -. PUNCT B-O - -BiPAP PROPN B-AC -: PUNCT B-O -Bilevel NOUN B-LF -positive ADJ I-LF -airway NOUN I-LF -pressure NOUN I-LF -; PUNCT B-O -IPAP PROPN B-AC -: PUNCT B-O -inspiratory ADJ B-LF -positive ADJ I-LF -airway NOUN I-LF -pressure NOUN I-LF -; PUNCT B-O -EPAP PROPN B-AC -: PUNCT B-O -expiratory ADJ B-LF -positive ADJ I-LF -airway NOUN I-LF -pressure NOUN I-LF -; PUNCT B-O -PLBV PROPN B-AC -: PUNCT B-O -pursed ADJ B-LF -lips NOUN I-LF -breathing VERB I-LF -ventilation NOUN I-LF -. PUNCT B-O - -Sodium PROPN B-LF -Calcium PROPN I-LF -exchangers NOUN I-LF -( PUNCT B-O -NCX PROPN B-AC -) PUNCT B-O -are AUX B-O -low ADJ B-O -affinity NOUN B-O -high ADJ B-O -capacity NOUN B-O -( PUNCT B-O -kcat NOUN B-O -2000–5000 NUM B-O -s−1 NUM B-O -) PUNCT B-O -antiporters NOUN B-O -that PRON B-O -can AUX B-O -rapidly ADV B-O -move VERB B-O -Ca2 NOUN B-O -+ NOUN B-O -ions NOUN B-O -across ADP B-O -the DET B-O -plasma NOUN B-O -membrane NOUN B-O -. PUNCT B-O - -Cells NOUN B-O -were AUX B-O -left VERB B-O -to PART B-O -expand VERB B-O -for ADP B-O -3–4 NUM B-O -consecutive ADJ B-O -days NOUN B-O -to PART B-O -form VERB B-O -a DET B-O -confluent ADJ B-O -monolayer NOUN B-O -( PUNCT B-O -unless SCONJ B-O -stated VERB B-O -otherwise ADV B-O -) PUNCT B-O -before SCONJ B-O -fixation NOUN B-O -with ADP B-O -4 NUM B-O -% NOUN B-O -paraformaldehyde NOUN B-LF -( PUNCT B-O -PFA PROPN B-AC -) PUNCT B-O -was AUX B-O -performed VERB B-O -. PUNCT B-O - -Moreover ADV B-O -, PUNCT B-O -HIF-2α PROPN B-AC -– PUNCT B-O -dependent ADJ B-O -up NOUN B-O -- PUNCT B-O -regulation NOUN B-O -of ADP B-O -interleukin NOUN B-LF -( PUNCT B-O -IL)-6 PROPN B-AC -in ADP B-O -FLS PROPN B-AC -stimulated VERB B-O -differentiation NOUN B-O -of ADP B-O -TH17 NOUN B-O -cells NOUN B-O -— PUNCT B-O -crucial ADJ B-O -effectors NOUN B-O -of ADP B-O -RA PROPN B-AC -pathogenesis NOUN B-O -. PUNCT B-O - -We PRON B-O -tested VERB B-O -2 NUM B-O -low ADJ B-O -- PUNCT B-O -intensity NOUN B-O -versions NOUN B-O -of ADP B-O -CBT PROPN B-AC -in ADP B-O -a DET B-O -trial NOUN B-O -( PUNCT B-O -guided VERB B-O -self NOUN B-O -- PUNCT B-O -help NOUN B-O -and CCONJ B-O -supported VERB B-O -computerised ADJ B-LF -cognitive ADJ I-LF -- PUNCT I-LF -behaviour NOUN I-LF -therapy NOUN I-LF -[ PUNCT B-O -cCBT PROPN B-AC -] PUNCT B-O -) PUNCT B-O -, PUNCT B-O -testing VERB B-O -their PRON B-O -impact NOUN B-O -on ADP B-O -patients NOUN B-O -with ADP B-O -OCD PROPN B-AC -when SCONJ B-O -provided VERB B-O -prior ADV B-O -to ADP B-O -CBT PROPN B-AC -with ADP B-O -a DET B-O -therapist NOUN B-O -. PUNCT B-O - -The DET B-O -pelvic ADJ B-O -inlet NOUN B-O -anterior ADJ B-LF -- PUNCT I-LF -posterior ADJ I-LF -diameter NOUN I-LF -( PUNCT B-O -APD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -also ADV B-O -called VERB B-O -the DET B-O -obstetric ADJ B-O -conjugate NOUN B-O -, PUNCT B-O -was AUX B-O -measured VERB B-O -from ADP B-O -the DET B-O -anterior ADJ B-O -cortical ADJ B-O -surface NOUN B-O -of ADP B-O -the DET B-O -sacrovertebral ADJ B-O -angel NOUN B-O -( PUNCT B-O -promontory NOUN B-O -) PUNCT B-O -to ADP B-O -the DET B-O -closest ADJ B-O -point NOUN B-O -on ADP B-O -the DET B-O -convex ADJ B-O -posterior ADJ B-O -- PUNCT B-O -superior ADJ B-O -aspect NOUN B-O -of ADP B-O -the DET B-O -pubis NOUN B-O -symphysis NOUN B-O -. PUNCT B-O - -By ADP B-O -contrast NOUN B-O -, PUNCT B-O -enhanced VERB B-O -green ADJ B-O -- PUNCT B-O -fusion NOUN B-O -protein NOUN B-O -- PUNCT B-O -maximakinin NOUN B-LF -( PUNCT B-O -EGFP PROPN B-AC -- PUNCT B-O -MK PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -much ADV B-O -brighter ADJ B-O -, PUNCT B-O -nanomolar ADJ B-O -affinity NOUN B-O -agonist NOUN B-O -of ADP B-O -the DET B-O -rabbit NOUN B-O -B2R PROPN B-AC -that PRON B-O -does AUX B-O -not PART B-O -bind VERB B-O -to ADP B-O -ACE PROPN B-AC -[ PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Currently ADV B-O -there PRON B-O -is VERB B-O -no DET B-O -standard ADJ B-O -second ADJ B-O -- PUNCT B-O -line NOUN B-O -treatment NOUN B-O -for ADP B-O -steroid NOUN B-LF -- PUNCT I-LF -refractory ADJ I-LF -aGVHD PROPN B-AC -( PUNCT B-O -SR PROPN B-AC -- PUNCT B-O -aGVHD PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Numerous ADJ B-O -strategies NOUN B-O -to PART B-O -treat VERB B-O -SR PROPN B-AC -- PUNCT B-O -aGVHD PROPN B-AC -have AUX B-O -been AUX B-O -reported VERB B-O -, PUNCT B-O -but CCONJ B-O -results NOUN B-O -have AUX B-O -been AUX B-O -disappointing ADJ B-O -with ADP B-O -varying VERB B-O -response NOUN B-O -rates NOUN B-O -and CCONJ B-O -long ADJ B-O -term NOUN B-O -overall ADJ B-LF -survival NOUN I-LF -( PUNCT B-O -OS PROPN B-AC -) PUNCT B-O -of ADP B-O -only ADV B-O -20–30 NUM B-O -% NOUN B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Raw ADJ B-O -data NOUN B-O -for ADP B-O -panels NOUN B-O -A NOUN B-O -and CCONJ B-O -B NOUN B-O -can AUX B-O -be AUX B-O -found VERB B-O -in ADP B-O -the DET B-O -Supporting NOUN B-O -Information NOUN B-O -section NOUN B-O -S2 NOUN B-O -Data NOUN B-O -file NOUN B-O -. PUNCT B-O - -fMLP PROPN B-AC -, PUNCT B-O -N NOUN B-LF -- PUNCT I-LF -formylMethionyl NOUN I-LF -- PUNCT I-LF -Leucyl NOUN I-LF -- PUNCT I-LF -Phenylalanine NOUN I-LF -; PUNCT B-O -KD PROPN B-AC -, PUNCT B-O -knockdown NOUN B-LF -; PUNCT B-O -NSshRNA PROPN B-AC -, PUNCT B-O -nonspecific ADJ B-LF -shRNA NOUN I-LF -shRNA PROPN B-AC -. PUNCT B-O - -To PART B-O -determine VERB B-O -whether SCONJ B-O -this DET B-O -inflammatory ADJ B-O -response NOUN B-O -is AUX B-O -reflected VERB B-O -by ADP B-O -up NOUN B-O -- ADJ B-O -regulation NOUN B-O -of ADP B-O -pro ADJ B-O -- ADJ B-O -inflammatory ADJ B-O -markers NOUN B-O -, PUNCT B-O -we PRON B-O -performed VERB B-O -reverse ADJ B-LF -transcription NOUN I-LF -PCR NOUN I-LF -( PUNCT B-O -RT-PCR PROPN B-AC -) PUNCT B-O -on ADP B-O -larvae NOUN B-O -carrying VERB B-O -a DET B-O -transformed VERB B-O -goblet NOUN B-O -cell NOUN B-O -burden NOUN B-O -, PUNCT B-O -and CCONJ B-O -indeed ADV B-O -we PRON B-O -see VERB B-O -increased VERB B-O -levels NOUN B-O -of ADP B-O -tnfα NOUN B-O -, PUNCT B-O -cxcl1 NOUN B-O -, PUNCT B-O -il8 NOUN B-O -, PUNCT B-O -ifn1 NOUN B-O -, PUNCT B-O -and CCONJ B-O -il1β NOUN B-O -in ADP B-O -these DET B-O -larvae NOUN B-O -( PUNCT B-O -Figure NOUN B-O -S1A NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Moreover ADV B-O -, PUNCT B-O -if SCONJ B-O -we PRON B-O -look VERB B-O -by ADP B-O -quantitative ADJ B-LF -PCR NOUN I-LF -( PUNCT B-O -qPCR PROPN B-AC -) PUNCT B-O -at ADP B-O -levels NOUN B-O -of ADP B-O -two NUM B-O -of ADP B-O -these DET B-O -genes NOUN B-O -, PUNCT B-O -il1β NOUN B-O -and CCONJ B-O -cxcl1 NOUN B-O -, PUNCT B-O -we PRON B-O -see VERB B-O -their PRON B-O -clear ADJ B-O -induction NOUN B-O -in ADP B-O -larvae NOUN B-O -where SCONJ B-O -V12RAS NOUN B-O -expression NOUN B-O -is AUX B-O -induced VERB B-O -by ADP B-O -heat NOUN B-O -shock NOUN B-O -only ADV B-O -6 NUM B-O -h NOUN B-O -before ADP B-O -RNA NOUN B-O -extraction NOUN B-O -, PUNCT B-O -suggesting VERB B-O -that SCONJ B-O -pro ADJ B-O -- ADJ B-O -inflammatory ADJ B-O -gene NOUN B-O -expression NOUN B-O -is AUX B-O -a DET B-O -rapid ADJ B-O -response NOUN B-O -to ADP B-O -V12RAS NOUN B-O -expression NOUN B-O -( PUNCT B-O -Figure NOUN B-O -S1B NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Replacing VERB B-O -NNRTIs PROPN B-AC -by ADP B-O -dolutegravir PROPN B-LF -( PUNCT B-O -DTG PROPN B-AC -) PUNCT B-O -may AUX B-O -curb VERB B-O -the DET B-O -spread NOUN B-O -of ADP B-O -resistance NOUN B-O -, PUNCT B-O -but CCONJ B-O -it PRON B-O -is AUX B-O -unclear ADJ B-O -how SCONJ B-O -effective ADJ B-O -this DET B-O -switch NOUN B-O -will AUX B-O -be AUX B-O -and CCONJ B-O -which DET B-O -patient NOUN B-O -groups NOUN B-O -should AUX B-O -be AUX B-O -switched VERB B-O -from ADP B-O -NNRTI PROPN B-AC -to ADP B-O -DTG PROPN B-AC -. PUNCT B-O - -Transcriptome ADJ B-O -sequencing NOUN B-O -analysis NOUN B-O -detected VERB B-O -106 NUM B-O -differentially ADV B-LF -expressed VERB I-LF -genes NOUN I-LF -( PUNCT B-O -DEGs PROPN B-AC -) PUNCT B-O -related VERB B-O -to ADP B-O -oxidative ADJ B-O -stress NOUN B-O -. PUNCT B-O - -Finally ADV B-O -, PUNCT B-O -demographic ADJ B-O -information NOUN B-O -was AUX B-O -collected VERB B-O -, PUNCT B-O -including VERB B-O -the DET B-O -Integrated PROPN B-LF -Systematic PROPN I-LF -Care PROPN I-LF -for ADP I-LF -Older PROPN I-LF -People PROPN I-LF -( PUNCT B-O -ISCOPE PROPN B-AC -) PUNCT B-O -questionnaire NOUN B-O -, PUNCT B-O -to PART B-O -determine VERB B-O -complex ADJ B-O -health NOUN B-O -problems NOUN B-O -in ADP B-O -the DET B-O -participants NOUN B-O -[ PUNCT B-O -35 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -chicken NOUN B-O -appears VERB B-O -to PART B-O -lack VERB B-O -the DET B-O -ortholog NOUN B-O -for ADP B-O -the DET B-O -human ADJ B-O -GABABR PROPN B-AC -( PUNCT B-O -gamma NOUN B-LF -aminobutyric ADJ I-LF -acid NOUN I-LF -– PUNCT I-LF -binding VERB I-LF -receptor NOUN I-LF -) PUNCT B-O -1 NUM B-O -. PUNCT B-O - -Mice NOUN B-O -8–10 NUM B-O -weeks NOUN B-O -old ADJ B-O -infected VERB B-O -intraperitoneally ADV B-O -with ADP B-O -102 NUM B-O -( PUNCT B-O -A&E NOUN B-O -) PUNCT B-O -, PUNCT B-O -103 NUM B-O -( PUNCT B-O -B&F NOUN B-O -) PUNCT B-O -, PUNCT B-O -104 NUM B-O -( PUNCT B-O -C&G NOUN B-O -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -106 NUM B-O -( PUNCT B-O -D&H NOUN B-O -) PUNCT B-O -plaque NOUN B-O -forming VERB B-O -units NOUN B-O -( PUNCT B-O -pfu NOUN B-O -) PUNCT B-O -Smith PROPN B-O -strain NOUN B-O -mCMV PROPN B-AC -had VERB B-O -peripheral ADJ B-LF -blood NOUN I-LF -mononuclear ADJ I-LF -cells NOUN I-LF -( PUNCT B-O -PBMC PROPN B-AC -) PUNCT B-O -evaluated VERB B-O -16 NUM B-O -weeks NOUN B-O -after ADP B-O -infection NOUN B-O -for ADP B-O -inflationary ADJ B-O -mCMV PROPN B-AC -- PUNCT B-O -specific ADJ B-O -T NOUN B-O -- PUNCT B-O -cells NOUN B-O -. PUNCT B-O - -Error NOUN B-O -bars NOUN B-O -were AUX B-O -equal ADJ B-O -to ADP B-O -the DET B-O -standard ADJ B-LF -error NOUN I-LF -of ADP I-LF -the DET I-LF -mean NOUN I-LF -( PUNCT B-O -SEM PROPN B-AC -) PUNCT B-O -of ADP B-O -a DET B-O -subset NOUN B-O -of ADP B-O -the DET B-O -local ADJ B-O -UIs PROPN B-AC -. PUNCT B-O - -The DET B-O -subset NOUN B-O -was AUX B-O -chosen VERB B-O -so SCONJ B-O -that SCONJ B-O -no DET B-O -two NUM B-O -triangles NOUN B-O -shared VERB B-O -an DET B-O -edge NOUN B-O -, PUNCT B-O -ensuring VERB B-O -that SCONJ B-O -local ADJ B-O -correlations NOUN B-O -in ADP B-O -the DET B-O -UI PROPN B-AC -did AUX B-O -not PART B-O -artificially ADV B-O -reduce VERB B-O -the DET B-O -SEM PROPN B-AC -. PUNCT B-O - -The DET B-O -SEM PROPN B-AC -was AUX B-O -validated VERB B-O -using VERB B-O -a DET B-O -bootstrap NOUN B-O -simulation NOUN B-O -. PUNCT B-O - -We PRON B-O -find VERB B-O -that SCONJ B-O -parasites NOUN B-O -undergoing VERB B-O -delayed VERB B-O -death NOUN B-O -exhibited VERB B-O -disrupted VERB B-O -prenylation NOUN B-O -of ADP B-O -proteins NOUN B-O -required VERB B-O -for ADP B-O -haemoglobin NOUN B-O -uptake NOUN B-O -and CCONJ B-O -the DET B-O -biogenesis NOUN B-O -of ADP B-O -the DET B-O -digestive ADJ B-LF -vacuole NOUN I-LF -( PUNCT B-O -DV PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -We PRON B-O -further ADV B-O -demonstrate VERB B-O -defective ADJ B-O -localisation NOUN B-O -of ADP B-O -prenylated VERB B-O -trafficking NOUN B-O -mediators NOUN B-O -, PUNCT B-O -defective ADJ B-O -uptake NOUN B-O -of ADP B-O -haemoglobin NOUN B-O -, PUNCT B-O -and CCONJ B-O -a DET B-O -disrupted VERB B-O -DV PROPN B-AC -in ADP B-O -these DET B-O -parasites NOUN B-O -. PUNCT B-O - -Tuberculosis NOUN B-LF -( PUNCT B-O -TB PROPN B-AC -) PUNCT B-O -is AUX B-O -one NUM B-O -of ADP B-O -the DET B-O -leading VERB B-O -causes NOUN B-O -of ADP B-O -death NOUN B-O -from ADP B-O -infectious ADJ B-O -disease NOUN B-O -worldwide ADV B-O -, PUNCT B-O -and CCONJ B-O -it PRON B-O -kills VERB B-O -around ADV B-O -1.7 NUM B-O -million NUM B-O -people NOUN B-O -each DET B-O -year NOUN B-O -. PUNCT B-O - -In ADP B-O -brief NOUN B-O -, PUNCT B-O -a DET B-O -simplified ADJ B-O -form NOUN B-O -of ADP B-O -sepsis NOUN B-LF -- PUNCT I-LF -related VERB I-LF -organ NOUN B-LF -failure NOUN I-LF -assessment NOUN I-LF -( PUNCT B-O -SOFA PROPN B-AC -) PUNCT B-O -score NOUN B-O -[ PUNCT B-O -23]-based VERB B-O -scoring NOUN B-O -system NOUN B-O -, PUNCT B-O -the DET B-O -CLIF-C PROPN B-AC -OF PROPN B-AC -score NOUN B-O -, PUNCT B-O -was AUX B-O -used VERB B-O -to PART B-O -evaluate VERB B-O -OF PROPN B-AC -. PUNCT B-O - -The DET B-O -CLIF PROPN B-AC --CACLF PROPN B-AC -score NOUN B-O -was AUX B-O -developed VERB B-O -by ADP B-O -combining VERB B-O -the DET B-O -CLIF PROPN B-AC --COF PROPN B-AC -score NOUN B-O -and CCONJ B-O -two NUM B-O -other ADJ B-O -independent ADJ B-O -prognostic ADJ B-O -factors NOUN B-O -, PUNCT B-O -age NOUN B-O -, PUNCT B-O -and CCONJ B-O -white ADJ B-LF -blood NOUN I-LF -cell NOUN I-LF -( PUNCT B-O -WBC PROPN B-AC -) PUNCT B-O -count NOUN B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -three NUM B-O -- ADJ B-O -parameter NOUN B-O -model NOUN B-O -that PRON B-O -did AUX B-O -not PART B-O -incorporate VERB B-O -inter ADJ B-O -- ADJ B-O -item ADJ B-O -homogeneity NOUN B-O -( PUNCT B-O -as SCONJ B-O -shown VERB B-O -in ADP B-O -Figure NOUN B-O -8A NUM B-O -) PUNCT B-O -accounted VERB B-O -for ADP B-O -only ADV B-O -51 NUM B-O -% NOUN B-O -of ADP B-O -the DET B-O -variance NOUN B-O -( PUNCT B-O -r NOUN B-O -2 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -had VERB B-O -an DET B-O -Akaike PROPN B-LF -information NOUN I-LF -criterion NOUN I-LF -( PUNCT B-O -AIC PROPN B-AC -) PUNCT B-O -value NOUN B-O -( PUNCT B-O -see VERB B-O -Methods NOUN B-O -) PUNCT B-O -of ADP B-O -1,010 NUM B-O -( PUNCT B-O -higher ADJ B-O -AIC PROPN B-AC -values NOUN B-O -indicate VERB B-O -worse ADJ B-O -fit NOUN B-O -[ X B-O -27 NUM B-O -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -D13 NOUN B-O -, PUNCT B-O -diploid ADJ B-O -cycle NOUN B-O -13 NUM B-O -embryos NOUN B-O -; PUNCT B-O -eve2 PROPN B-AC -, PUNCT B-O -even ADV B-LF -skipped VERB I-LF -stripe NOUN I-LF -2 NUM I-LF -; PUNCT B-O -Frs PROPN B-AC -, PUNCT B-O -Frühstart NOUN B-LF -; PUNCT B-O -H14 NOUN B-O -, PUNCT B-O -haploid ADJ B-O -cycle NOUN B-O -14 NUM B-O -embryos NOUN B-O -; PUNCT B-O -kni PROPN B-AC -, PUNCT B-O -knirps NOUN B-LF -; PUNCT B-O -N PROPN B-AC -, PUNCT B-O -ratio NOUN B-LF -of ADP I-LF -nuclei NOUN I-LF -to ADP I-LF -cytoplasm NOUN I-LF -; PUNCT B-O -PCNA PROPN B-O -, PUNCT B-O -proliferating VERB B-O -cell NOUN B-O -nuclear ADJ B-O -antigen NOUN B-O -. PUNCT B-O - -We PRON B-O -ectopically ADV B-O -expressed VERB B-O -N. PROPN B-O -crassa NOUN B-O -Puf3 PROPN B-O -protein NOUN B-O -fused VERB B-O -to ADP B-O -a DET B-O -tandem NOUN B-LF -affinity NOUN I-LF -purification NOUN I-LF -tag NOUN I-LF -( PUNCT B-O -TAP-tag PROPN B-AC -) PUNCT B-O -in ADP B-O -a DET B-O -S. PROPN B-O -cerevisiae NOUN B-O -strain NOUN B-O -missing VERB B-O -endogenous ADJ B-O -Puf PROPN B-AC -proteins NOUN B-O -, PUNCT B-O -Puf1 PROPN B-O -- PUNCT B-O -5 NUM B-O -( PUNCT B-O -derived VERB B-O -from ADP B-O -5Δpufs NOUN B-O -strain NOUN B-O -[ PUNCT B-O -47 NUM B-O -] PUNCT B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -we PRON B-O -identified VERB B-O -the DET B-O -RNAs NOUN B-O -bound VERB B-O -by ADP B-O -N. PROPN B-O -crassa NOUN B-O -Puf3 PROPN B-O -( PUNCT B-O -Materials NOUN B-O -and CCONJ B-O -Methods PROPN B-O -) PUNCT B-O -. PUNCT B-O - -This DET B-O -periodicity NOUN B-O -was AUX B-O -evident ADJ B-O -when SCONJ B-O -we PRON B-O -aligned VERB B-O -all DET B-O -coding VERB B-O -regions NOUN B-O -to ADP B-O -the DET B-O -first ADJ B-O -nucleosome NOUN B-O -downstream ADV B-O -of ADP B-O -the DET B-O -TSS PROPN B-AC -and CCONJ B-O -ranked VERB B-O -all DET B-O -these DET B-O -genes NOUN B-O -by ADP B-O -a DET B-O -nucleosome NOUN B-LF -positioning NOUN I-LF -periodicity NOUN I-LF -( PUNCT B-O -NPP PROPN B-AC -) PUNCT B-O -score NOUN B-O -applied VERB B-O -to ADP B-O -the DET B-O -coding VERB B-O -region NOUN B-O -( PUNCT B-O -Figure NOUN B-O -3A NUM B-O -; PUNCT B-O -Materials NOUN B-O -and CCONJ B-O -Methods NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Therefore ADV B-O -, PUNCT B-O -the DET B-O -study NOUN B-O -aimed VERB B-O -to ADP B-O -suggest VERB B-O -the DET B-O -chemical ADJ B-O -composition NOUN B-O -of ADP B-O -C. PROPN B-O -obtusa PROPN B-O -leaf NOUN B-O -extract NOUN B-O -using VERB B-O -LC PROPN B-O -- PUNCT B-O -MS PROPN B-O -. PUNCT B-O - -To PART B-O -assess VERB B-O -if SCONJ B-O -, PUNCT B-O -besides SCONJ B-O -the DET B-O -antioxidant ADJ B-O -activity NOUN B-O -, PUNCT B-O -C. PROPN B-O -obtusa PROPN B-O -would AUX B-O -exhibit VERB B-O -an DET B-O -anti ADJ B-O -aging ADJ B-O -effect NOUN B-O -and CCONJ B-O -which DET B-O -mechanisms NOUN B-O -would AUX B-O -be AUX B-O -involved VERB B-O -in ADP B-O -it PRON B-O -, PUNCT B-O -we PRON B-O -evaluated VERB B-O -the DET B-O -effect NOUN B-O -of ADP B-O -the DET B-O -extract NOUN B-O -on ADP B-O -keratinocytes NOUN B-O -and CCONJ B-O -fibroblasts NOUN B-O -exposed VERB B-O -to ADP B-O -UV PROPN B-AC -radiation NOUN B-O -and CCONJ B-O -analyzed VERB B-O -protein NOUN B-O -carbonyl NOUN B-O -, PUNCT B-O -collagen NOUN B-O -, PUNCT B-O -hyaluronic ADJ B-LF -acid NOUN I-LF -( PUNCT B-O -HA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -metalloproteinase-1 NOUN B-O -( PUNCT B-O -MMP-1 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -IL-1 NOUN B-O -β PUNCT B-O -and CCONJ B-O -IL-6 NOUN B-O -contents NOUN B-O -. PUNCT B-O - -We PRON B-O -first ADV B-O -analyzed VERB B-O -differences NOUN B-O -between ADP B-O -wards NOUN B-O -on ADP B-O -the DET B-O -activity NOUN B-O -categories NOUN B-O -: PUNCT B-O -Direct PROPN B-LF -Patient PROPN I-LF -Care PROPN I-LF -( PUNCT B-O -DPC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Collective PROPN B-LF -Patient PROPN I-LF -Care PROPN I-LF -( PUNCT B-O -CPC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -General PROPN B-LF -Tasks PROPN I-LF -( PUNCT B-O -GT PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Other ADJ B-LF -Tasks PROPN I-LF -( PUNCT B-O -OT PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Compositional ADJ B-O -analysis NOUN B-O -dictates VERB B-O -that SCONJ B-O -one NUM B-O -variable NOUN B-O -needs VERB B-O -to PART B-O -be AUX B-O -chosen VERB B-O -as ADP B-O -a DET B-O -reference NOUN B-O -variable NOUN B-O -, PUNCT B-O -to PART B-O -compare VERB B-O -the DET B-O -others NOUN B-O -against ADP B-O -. PUNCT B-O - -Specifically ADV B-O -, PUNCT B-O -we PRON B-O -loaded VERB B-O -retinas NOUN B-O -using VERB B-O -the DET B-O -acetoxymethyl NOUN B-LF -ester NOUN I-LF -( PUNCT B-O -AM-ester PROPN B-AC -) PUNCT B-O -of ADP B-O -this DET B-O -dye NOUN B-O -( PUNCT B-O -see VERB B-O -Methods NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -then ADV B-O -we PRON B-O -mechanically ADV B-O -dissociated VERB B-O -individual ADJ B-O -rod NOUN B-O -photoreceptors NOUN B-O -and/or CCONJ B-O -OSs PROPN B-AC -. PUNCT B-O - -We PRON B-O -viewed VERB B-O -the DET B-O -preparation NOUN B-O -using VERB B-O -IR PROPN B-AC -illumination NOUN B-O -at ADP B-O -750 NUM B-O -nm NOUN B-O -and CCONJ B-O -an DET B-O -IR PROPN B-AC -- PUNCT B-O -sensitive ADJ B-O -video NOUN B-O -camera NOUN B-O -attached VERB B-O -to ADP B-O -the DET B-O -microscope NOUN B-O -. PUNCT B-O - -For ADP B-O -some DET B-O -years NOUN B-O -, PUNCT B-O -the DET B-O -maximum ADJ B-LF -relaxation NOUN I-LF -rate NOUN I-LF -( PUNCT B-O -MRR PROPN B-AC -) PUNCT B-O -of ADP B-O -the DET B-O -inspiratory ADJ B-O -muscles NOUN B-O -has AUX B-O -been AUX B-O -used VERB B-O -as ADP B-O -an DET B-O -indirect ADJ B-O -marker NOUN B-O -of ADP B-O -fatigue NOUN B-O -and CCONJ B-O -overload NOUN B-O -of ADP B-O -the DET B-O -inspiratory ADJ B-O -muscles NOUN B-O -. PUNCT B-O - -Zhang PROPN B-O -et PROPN B-O -al NOUN B-O -. PUNCT B-O - -[ X B-O -16 X B-O -] X B-O -demonstrated VERB B-O -that SCONJ B-O -Shp2 PROPN B-O -controls VERB B-O -phosphorylation NOUN B-O -and CCONJ B-O -activation NOUN B-O -of ADP B-O -Src PROPN B-LF -family NOUN I-LF -kinases NOUN I-LF -( PUNCT B-O -SFKs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -in ADP B-O -that SCONJ B-O -SFK PROPN B-AC -activity NOUN B-O -is AUX B-O -reduced VERB B-O -in ADP B-O -the DET B-O -absence NOUN B-O -of ADP B-O -Shp2 PROPN B-O -, PUNCT B-O -due ADP B-O -to ADP B-O -hyperphosphorylation NOUN B-O -of ADP B-O -the DET B-O -inhibitory ADJ B-O -phosphorylation NOUN B-O -site NOUN B-O -. PUNCT B-O - -PAM PROPN B-AC -, PUNCT B-O -protospacer NOUN B-LF -adjacent ADJ I-LF -motif NOUN I-LF -; PUNCT B-O -SpCas9 PROPN B-AC -, PUNCT B-O -Streptococcus NOUN B-LF -pyogenes NOUN I-LF -Cas9 PROPN I-LF -; PUNCT B-O -WT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -- PUNCT I-LF -type NOUN I-LF -. PUNCT B-O - -Anthranilic ADJ B-LF -acid NOUN I-LF -( PUNCT B-O -AA PROPN B-AC -) PUNCT B-O -supplementation NOUN B-O -rescues VERB B-O -gut NOUN B-O -granule NOUN B-O -and CCONJ B-O -DF PROPN B-AC -. PUNCT B-O - -( PUNCT B-O -A X B-O -, PUNCT B-O -B NOUN B-O -) PUNCT B-O -Incubation NOUN B-O -of ADP B-O -tdo-2(RNAi NOUN B-O -) PUNCT B-O -worms NOUN B-O -in ADP B-O -5 NUM B-O -mM PROPN B-O -AA PROPN B-AC -leads VERB B-O -to ADP B-O -gut NOUN B-O -granule NOUN B-O -fluorescence NOUN B-O -similar ADJ B-O -to ADP B-O -wild ADJ B-O -type NOUN B-O -. PUNCT B-O - -( PUNCT B-O -A X B-O -) PUNCT B-O -Effect NOUN B-O -on ADP B-O -gut NOUN B-O -granule NOUN B-O -fluorescence NOUN B-O -of ADP B-O -incubation NOUN B-O -in ADP B-O -a DET B-O -range NOUN B-O -of ADP B-O -AA PROPN B-AC -concentrations NOUN B-O -. PUNCT B-O - -5 NUM B-O -mM PROPN B-O -AA PROPN B-AC -gives VERB B-O -fluorescence NOUN B-O -levels NOUN B-O -similar ADJ B-O -to ADP B-O -wild ADJ B-O -type NOUN B-O -. PUNCT B-O - -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -Epifluorescence NOUN B-O -microscopy NOUN B-O -reveals VERB B-O -restoration NOUN B-O -of ADP B-O -gut NOUN B-O -granule NOUN B-O -fluorescence NOUN B-O -by ADP B-O -incubation NOUN B-O -in ADP B-O -5 NUM B-O -mM PROPN B-O -AA PROPN B-AC -. PUNCT B-O - -( PUNCT B-O -C X B-O -, PUNCT B-O -D NOUN B-O -) PUNCT B-O -Incubation NOUN B-O -of ADP B-O -tdo-2(RNAi NOUN B-O -) PUNCT B-O -worms NOUN B-O -in ADP B-O -5 NUM B-O -mM PROPN B-O -AA PROPN B-AC -leads VERB B-O -to ADP B-O -DF PROPN B-AC -similar ADJ B-O -to ADP B-O -wild ADJ B-O -type NOUN B-O -. PUNCT B-O - -( PUNCT B-O -C X B-O -) PUNCT B-O -Effects NOUN B-O -of ADP B-O -tdo-2(RNAi NOUN B-O -) PUNCT B-O -and CCONJ B-O -AA PROPN B-AC -supplementation NOUN B-O -on ADP B-O -peak ADJ B-O -DF PROPN B-AC -. PUNCT B-O - -( PUNCT B-O -D NOUN B-O -) PUNCT B-O -Similar ADJ B-O -kinetics NOUN B-O -of ADP B-O -DF PROPN B-AC -in ADP B-O -control NOUN B-O -worms NOUN B-O -and CCONJ B-O -tdo-2(RNAi NOUN B-O -) PUNCT B-O -worms NOUN B-O -with ADP B-O -AA PROPN B-AC -- PUNCT B-O -replenished VERB B-O -gut NOUN B-O -granules NOUN B-O -, PUNCT B-O -even ADV B-O -though SCONJ B-O -only ADV B-O -the DET B-O -former ADJ B-O -can AUX B-O -synthesize VERB B-O -AA PROPN B-AC -. PUNCT B-O - -Signal ADJ B-LF -transducer NOUN I-LF -and CCONJ I-LF -activator NOUN I-LF -of ADP I-LF -transcription NOUN I-LF -5b NOUN I-LF -( PUNCT B-O -STAT5b PROPN B-AC -) PUNCT B-O -is AUX B-O -one NUM B-O -of ADP B-O -seven NUM B-O -mammalian ADJ B-O -STAT PROPN B-O -transcription NOUN B-O -factors NOUN B-O -[ PUNCT B-O -1 NUM B-O -, PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Oxidative ADJ B-O -stress NOUN B-O -refers VERB B-O -to PART B-O -the DET B-O -imbalance NOUN B-O -between ADP B-O -the DET B-O -products NOUN B-O -of ADP B-O -reactive ADJ B-LF -oxygen NOUN I-LF -species NOUN I-LF -( PUNCT B-O -ROS PROPN B-AC -) PUNCT B-O -and CCONJ B-O -the DET B-O -biological ADJ B-O -ability NOUN B-O -to PART B-O -detoxify VERB B-O -them PRON B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -U5 PROPN B-O -is AUX B-O -identical ADJ B-O -to ADP B-O -U3 PROPN B-O -except SCONJ B-O -that SCONJ B-O -it PRON B-O -lacks VERB B-O -the DET B-O -third ADJ B-O -randomized VERB B-O -ankyrin NOUN B-LF -repeat NOUN I-LF -( PUNCT B-O -AR PROPN B-AC -) PUNCT B-O -domain NOUN B-O -. PUNCT B-O - -We PRON B-O -used VERB B-O -an DET B-O -iterative ADJ B-O -immuno ADJ B-O -- PUNCT B-O -FISH PROPN B-AC -( PUNCT B-O -fluorescence NOUN B-LF -in ADP I-LF -situ NOUN I-LF -hybridization NOUN I-LF -) PUNCT B-O -approach NOUN B-O -[ X B-O -41 X B-O -] X B-O -to ADP B-O -investigate VERB B-O -the DET B-O -organization NOUN B-O -of ADP B-O -the DET B-O -chromosome NOUN B-O -loops NOUN B-O -associated VERB B-O -with ADP B-O -pairs NOUN B-O -of ADP B-O -sister NOUN B-O -chromatids NOUN B-O -, PUNCT B-O -both PRON B-O -relative ADJ B-O -to ADP B-O -each DET B-O -other ADJ B-O -and CCONJ B-O -in ADP B-O -relationship NOUN B-O -to ADP B-O -the DET B-O -chromosome NOUN B-O -axis NOUN B-O -. PUNCT B-O - -Historically ADV B-O -, PUNCT B-O -PJP PROPN B-AC -affects VERB B-O -mostly ADV B-O -patients NOUN B-O -with ADP B-O -human ADJ B-LF -immunodeficiency NOUN I-LF -virus NOUN I-LF -( PUNCT B-O -HIV PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -However ADV B-O -, PUNCT B-O -prevalence NOUN B-O -of ADP B-O -patients NOUN B-O -with ADP B-O -HIV PROPN B-AC -- PUNCT B-O -related VERB B-O -PJP PROPN B-AC -has AUX B-O -decreased VERB B-O -with ADP B-O -the DET B-O -use NOUN B-O -of ADP B-O -highly ADV B-O -active ADJ B-O -antiretroviral ADJ B-O -therapy NOUN B-O -and CCONJ B-O -routine ADJ B-O -PJP PROPN B-AC -prophylaxis NOUN B-O -[ X B-O -1,2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -AID PROPN B-AC -, PUNCT B-O -auxin X B-LF -- PUNCT I-LF -inducible NOUN I-LF -degron PROPN I-LF -. PUNCT B-O - -We PRON B-O -calculated VERB B-O -the DET B-O -GSCORR PROPN B-AC -under ADP B-O -three NUM B-O -procedures NOUN B-O -of ADP B-O -noise NOUN B-O -regression NOUN B-O -: PUNCT B-O -( PUNCT B-O -1 X B-O -) PUNCT B-O -without ADP B-O -any DET B-O -noise NOUN B-O -regression NOUN B-O -, PUNCT B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -regressors NOUN B-O -including VERB B-O -head NOUN B-O -motion NOUN B-O -and CCONJ B-O -signals NOUN B-O -from ADP B-O -the DET B-O -ventricle NOUN B-O -and CCONJ B-O -white ADJ B-O -matter NOUN B-O -as SCONJ B-O -well ADV B-O -as SCONJ B-O -their PRON B-O -first ADJ B-O -order NOUN B-O -derivatives NOUN B-O -, PUNCT B-O -( PUNCT B-O -3 X B-O -) PUNCT B-O -regressors NOUN B-O -including VERB B-O -those PRON B-O -in ADP B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -plus CCONJ B-O -the DET B-O -RVT PROPN B-AC -and CCONJ B-O -heart NOUN B-LF -rate NOUN I-LF -( PUNCT B-O -HR PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -If SCONJ B-O -the DET B-O -task NOUN B-O -modulation NOUN B-O -of ADP B-O -GSCORR PROPN B-AC -( PUNCT B-O -i.e. X B-O -, PUNCT B-O -ΔGSCORR NOUN B-O -) PUNCT B-O -was AUX B-O -driven VERB B-O -merely ADV B-O -by ADP B-O -noise NOUN B-O -, PUNCT B-O -then ADV B-O -its PRON B-O -spatial ADJ B-O -pattern NOUN B-O -, PUNCT B-O -as SCONJ B-O -calculated VERB B-O -without ADP B-O -noise NOUN B-O -, PUNCT B-O -should AUX B-O -show VERB B-O -low ADJ B-O -degrees NOUN B-O -of ADP B-O -spatial ADJ B-O -similarity NOUN B-O -with ADP B-O -the DET B-O -one NUM B-O -after ADP B-O -noise NOUN B-O -regression NOUN B-O -. PUNCT B-O - -To PART B-O -overcome VERB B-O -the DET B-O -effects NOUN B-O -of ADP B-O -heterogeneous ADJ B-O -ELF5 PROPN B-O -induction NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1A NUM B-O -) PUNCT B-O -, PUNCT B-O -we PRON B-O -performed VERB B-O -intraductal ADJ B-O -allografts NOUN B-O -of ADP B-O -Fluorescence PROPN B-LF -- PUNCT I-LF -Activated VERB I-LF -Cell PROPN I-LF -Sorting PROPN I-LF -( PUNCT B-O -FACS)-sorted PROPN B-AC -( PUNCT B-O -Lin- PROPN B-O -and CCONJ B-O -CD24 PROPN B-O -+ PUNCT B-O -) PUNCT B-O -tumor NOUN B-O -cells NOUN B-O -that PRON B-O -were AUX B-O -either CCONJ B-O -EGFP PROPN B-O -( PUNCT B-O -ELF5 PROPN B-O -) PUNCT B-O -positive ADJ B-O -or CCONJ B-O -negative ADJ B-O -. PUNCT B-O - -Recently ADV B-O -, PUNCT B-O -Anaplastic ADJ B-LF -Lymphoma PROPN I-LF -Kinase PROPN I-LF -( PUNCT B-O -ALK PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -receptor NOUN B-O -kinase NOUN B-O -involved VERB B-O -in ADP B-O -pro ADJ B-O -- ADJ B-O -survival ADJ B-O -signaling NOUN B-O -, PUNCT B-O -was AUX B-O -shown VERB B-O -to PART B-O -be AUX B-O -upregulated ADJ B-O -in ADP B-O -advanced ADJ B-O -/ SYM B-O -metastatic ADJ B-O -neuroblastomas NOUN B-O -[ PUNCT B-O -13 NUM B-O -, PUNCT B-O -14 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -the DET B-O -one NUM B-O -- PUNCT B-O -stage NOUN B-O -approach NOUN B-O -, PUNCT B-O -we PRON B-O -added VERB B-O -a DET B-O -second ADJ B-O -sensitivity NOUN B-O -analysis NOUN B-O -to PART B-O -compare VERB B-O -our PRON B-O -results NOUN B-O -against ADP B-O -those PRON B-O -of ADP B-O -a DET B-O -procedure NOUN B-O -applying VERB B-O -multiple ADJ B-O -imputation NOUN B-O -to PART B-O -include VERB B-O -all DET B-O -participants NOUN B-O -( PUNCT B-O -an DET B-O -intention NOUN B-LF -- PUNCT I-LF -to PART I-LF -- PUNCT I-LF -treat VERB I-LF -[ X B-O -ITT PROPN B-AC -] X B-O -analysis NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Previous ADJ B-O -work NOUN B-O -by ADP B-O -our PRON B-O -group NOUN B-O -reported VERB B-O -that SCONJ B-O -long ADJ B-O -- PUNCT B-O -term NOUN B-O -, PUNCT B-O -ambient ADJ B-O -PM PROPN B-AC -exposure NOUN B-O -induces VERB B-O -hepatic ADJ B-O -fibrosis NOUN B-O -and CCONJ B-O -increased VERB B-O -ROS NOUN B-O -production NOUN B-O -in ADP B-O -the DET B-O -liver NOUN B-O -in ADP B-O -mice NOUN B-O -; PUNCT B-O -the DET B-O -combination NOUN B-O -of ADP B-O -PM PROPN B-AC -exposure NOUN B-O -and CCONJ B-O -a DET B-O -high ADJ B-LF -- PUNCT I-LF -fat NOUN I-LF -diet NOUN I-LF -( PUNCT B-O -HFD PROPN B-AC -) PUNCT B-O -aggravates VERB B-O -hepatic ADJ B-O -fibrosis NOUN B-O -[ PUNCT B-O -11 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -subsidy NOUN B-O -level NOUN B-O -of ADP B-O -30 NUM B-O -% NOUN B-O -was AUX B-O -based VERB B-O -on ADP B-O -the DET B-O -subsidy NOUN B-O -level NOUN B-O -used VERB B-O -in ADP B-O -the DET B-O -US PROPN B-O -Department PROPN B-O -of ADP B-O -Agriculture PROPN B-O -’s PART B-O -( PUNCT B-O -USDA PROPN B-AC -’s PART B-O -) PUNCT B-O -Healthy PROPN B-LF -Incentives PROPN I-LF -Pilot PROPN I-LF -( PUNCT B-O -HIP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -randomized ADJ B-O -controlled ADJ B-O -trial NOUN B-O -implemented VERB B-O -among ADP B-O -Supplemental PROPN B-LF -Nutrition PROPN I-LF -Assistant PROPN I-LF -Program PROPN I-LF -( PUNCT B-O -SNAP PROPN B-AC -) PUNCT B-O -participants NOUN B-O -to PART B-O -incentivize VERB B-O -F&V PROPN B-AC -consumption NOUN B-O -[ PUNCT B-O -37 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This PRON B-O -is AUX B-O -of ADP B-O -particular ADJ B-O -relevance NOUN B-O -because SCONJ B-O -obesity NOUN B-O -is AUX B-O -a DET B-O -risk NOUN B-O -factor NOUN B-O -for ADP B-O -a DET B-O -number NOUN B-O -of ADP B-O -cancer NOUN B-O -types NOUN B-O -, PUNCT B-O -including VERB B-O -multiple ADJ B-LF -myeloma NOUN I-LF -( PUNCT B-O -MM PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -5 NUM B-O -] PUNCT B-O -. PUNCT B-O - -During ADP B-O -the DET B-O -past NOUN B-O -decade NOUN B-O -, PUNCT B-O -large ADJ B-O -- PUNCT B-O -scale NOUN B-O -implementation NOUN B-O -of ADP B-O -long ADV B-LF -- PUNCT I-LF -lasting VERB I-LF -insecticidal ADJ I-LF -nets NOUN I-LF -( PUNCT B-O -LLINs PROPN B-AC -) PUNCT B-O -and CCONJ B-O -indoor ADJ B-LF -residual ADJ I-LF -spraying NOUN I-LF -( PUNCT B-O -IRS PROPN B-AC -) PUNCT B-O -has AUX B-O -played VERB B-O -a DET B-O -major ADJ B-O -role NOUN B-O -in ADP B-O -reducing VERB B-O -malaria NOUN B-O -morbidity NOUN B-O -and CCONJ B-O -mortality NOUN B-O -in ADP B-O -Africa PROPN B-O -south ADV B-O -of ADP B-O -the DET B-O -Sahara PROPN B-O -[ PUNCT B-O -2 NUM B-O -, PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -represent VERB B-O -the DET B-O -concentrations NOUN B-O -of ADP B-O -cytokines NOUN B-O -IL-1α PROPN B-AC -, PUNCT B-O -IL-1β PROPN B-AC -, PUNCT B-O -IL-6 PROPN B-AC -and CCONJ B-O -IL-10 PROPN B-AC -in ADP B-O -infants NOUN B-O -with ADP B-O -confirmed VERB B-O -late ADJ B-LF -- PUNCT I-LF -onset NOUN I-LF -sepsis NOUN I-LF -( PUNCT B-O -LOS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -possible ADJ B-O -LOS PROPN B-AC -and CCONJ B-O -no DET B-O -LOS PROPN B-AC -. PUNCT B-O - -The DET B-O -box NOUN B-O -plots NOUN B-O -show VERB B-O -the DET B-O -median ADJ B-O -and CCONJ B-O -interquartile ADJ B-O -range NOUN B-O -and CCONJ B-O -statistically ADV B-O -significant ADJ B-O -differences NOUN B-O -based VERB B-O -on ADP B-O -the DET B-O -Mann PROPN B-O -- PUNCT B-O -Whitney PROPN B-O -Test PROPN B-O -( PUNCT B-O -* PUNCT B-O -, PUNCT B-O -p<0.05 NUM B-O -and CCONJ B-O -* PUNCT B-O -* PUNCT B-O -, PUNCT B-O -p<0.005 NUM B-O -) PUNCT B-O -. PUNCT B-O - -From ADP B-O -a DET B-O -societal ADJ B-O -perspective NOUN B-O -including VERB B-O -informal ADJ B-O -healthcare NOUN B-O -costs NOUN B-O -and CCONJ B-O -lost VERB B-O -productivity NOUN B-O -, PUNCT B-O -respective ADJ B-O -ICERs PROPN B-AC -were AUX B-O -$ SYM B-O -14,576 NUM B-O -/ SYM B-O -QALY PROPN B-AC -and CCONJ B-O -$ SYM B-O -9,497 NUM B-O -/ SYM B-O -QALY PROPN B-AC -. PUNCT B-O - -Results NOUN B-O -were AUX B-O -robust ADJ B-O -in ADP B-O -probabilistic ADJ B-O -sensitivity NOUN B-O -analyses NOUN B-O -and CCONJ B-O -a DET B-O -range NOUN B-O -of ADP B-O -one NUM B-O -- PUNCT B-O -way NOUN B-O -sensitivity NOUN B-O -and CCONJ B-O -subgroup NOUN B-O -analyses NOUN B-O -, PUNCT B-O -including VERB B-O -by ADP B-O -different ADJ B-O -durations NOUN B-O -of ADP B-O -the DET B-O -intervention NOUN B-O -( PUNCT B-O -5 NUM B-O -, PUNCT B-O -10 NUM B-O -, PUNCT B-O -and CCONJ B-O -20 NUM B-O -years NOUN B-O -and CCONJ B-O -lifetime NOUN B-O -) PUNCT B-O -, PUNCT B-O -food NOUN B-O -subsidy NOUN B-O -levels NOUN B-O -( PUNCT B-O -20 NUM B-O -% PUNCT B-O -, PUNCT B-O -50 NUM B-O -% PUNCT B-O -) PUNCT B-O -, PUNCT B-O -insurance NOUN B-O -groups NOUN B-O -( PUNCT B-O -Medicare PROPN B-O -, PUNCT B-O -Medicaid PROPN B-O -, PUNCT B-O -and CCONJ B-O -dual ADJ B-O -- PUNCT B-O -eligible ADJ B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -beneficiary NOUN B-O -characteristics NOUN B-O -within ADP B-O -each DET B-O -insurance NOUN B-O -group NOUN B-O -( PUNCT B-O -age NOUN B-O -, PUNCT B-O -race NOUN B-O -/ SYM B-O -ethnicity NOUN B-O -, PUNCT B-O -education NOUN B-O -, PUNCT B-O -income NOUN B-O -, PUNCT B-O -and CCONJ B-O -Supplemental PROPN B-LF -Nutrition PROPN I-LF -Assistant PROPN I-LF -Program PROPN I-LF -[ PUNCT B-O -SNAP PROPN B-AC -] PUNCT B-O -status NOUN B-O -) PUNCT B-O -. PUNCT B-O - -t NOUN B-O -: PUNCT B-O -endoscopic ADJ B-LF -papillary ADJ I-LF -balloon NOUN I-LF -dilatation NOUN I-LF -duration NOUN B-O -time NOUN B-O -, PUNCT B-O -N NOUN B-O -: PUNCT B-O -number NOUN B-O -, PUNCT B-O -BMI PROPN B-O -: PUNCT B-O -body NOUN B-O -mass NOUN B-O -index NOUN B-O -, PUNCT B-O -BW PROPN B-O -: PUNCT B-O -body NOUN B-O -weight NOUN B-O -, PUNCT B-O -CV PROPN B-O -: PUNCT B-O -cardiovascular ADJ B-O -, PUNCT B-O -CM PROPN B-O -: PUNCT B-O -chest NOUN B-O -, PUNCT B-O -DM PROPN B-O -: PUNCT B-O -diabetes NOUN B-O -mellitus NOUN B-O -, PUNCT B-O -SBP PROPN B-O -: PUNCT B-O -systolic ADJ B-O -blood NOUN B-O -pressure NOUN B-O -, PUNCT B-O -BT PROPN B-O -: PUNCT B-O -body NOUN B-O -temperature NOUN B-O -, PUNCT B-O -HR NOUN B-O -: PUNCT B-O -heart NOUN B-O -rate NOUN B-O -, PUNCT B-O -RR PROPN B-O -: PUNCT B-O -respiratory ADJ B-O -rate NOUN B-O -, PUNCT B-O -WBC PROPN B-O -: PUNCT B-O -white ADJ B-O -blood NOUN B-O -cell NOUN B-O -count NOUN B-O -, PUNCT B-O -Hb PROPN B-O -: PUNCT B-O -hemoglobin NOUN B-O -, PUNCT B-O -PLT PROPN B-O -: PUNCT B-O -platelet NOUN B-O -, PUNCT B-O -INR PROPN B-O -: PUNCT B-O -international ADJ B-O -normalized VERB B-O -ratio NOUN B-O -, PUNCT B-O -ALT PROPN B-O -: PUNCT B-O -alanine NOUN B-O -aminotransferase NOUN B-O -, PUNCT B-O -AST PROPN B-O -: PUNCT B-O -aspartate NOUN B-O -aminotransferase NOUN B-O -, PUNCT B-O -BUN PROPN B-O -: PUNCT B-O -blood NOUN B-O -urea NOUN B-O -nitrogen NOUN B-O -, PUNCT B-O -Cr PROPN B-O -: PUNCT B-O -creatinine NOUN B-O -, PUNCT B-O -ALP PROPN B-O -: PUNCT B-O -alkaline NOUN B-O -phosphatase NOUN B-O -, PUNCT B-O -rGT PROPN B-O -: PUNCT B-O -gamma NOUN B-O -- PUNCT B-O -glutamyl NOUN B-O -transpeptidase NOUN B-O -, PUNCT B-O -Amy PROPN B-O -: PUNCT B-O -amylase NOUN B-O -, PUNCT B-O -Tbili PROPN B-O -: PUNCT B-O -total NOUN B-O -bilirubin NOUN B-O -, PUNCT B-O -CRP PROPN B-O -: PUNCT B-O -c NOUN B-O -- PUNCT B-O -reactive ADJ B-O -protein NOUN B-O -, PUNCT B-O -BD PROPN B-O -: PUNCT B-O -bile NOUN B-O -duct NOUN B-O -, PUNCT B-O -CBD PROPN B-AC -: PUNCT B-O -common ADJ B-LF -bile NOUN I-LF -duct NOUN I-LF -, PUNCT B-O -PTCD PROPN B-O -: PUNCT B-O -percutaneous ADJ B-O -transhepatic ADJ B-O -cholangiography NOUN B-O -and CCONJ B-O -drainage NOUN B-O -, PUNCT B-O -PTGBD PROPN B-O -: PUNCT B-O -percutaneous ADJ B-O -transhepatic ADJ B-O -gallbladder NOUN B-O -drainage NOUN B-O -, PUNCT B-O -EST PROPN B-AC -: PUNCT B-O -endoscopic ADJ B-LF -sphincterotomy NOUN I-LF -, PUNCT B-O -EPBD PROPN B-AC -: PUNCT B-O -endoscopic ADJ B-LF -papillary ADJ I-LF -balloon NOUN I-LF -dilatation NOUN I-LF -. PUNCT B-O - -Here ADV B-O -, PUNCT B-O -we PRON B-O -analyse VERB B-O -a DET B-O -newly ADV B-O -created VERB B-O -dataset NOUN B-O -of ADP B-O -trade NOUN B-O -challenges NOUN B-O -about ADP B-O -food NOUN B-O -, PUNCT B-O -beverage NOUN B-O -, PUNCT B-O -and CCONJ B-O -tobacco NOUN B-O -regulations NOUN B-O -among ADP B-O -122 NUM B-O -World PROPN B-LF -Trade PROPN I-LF -Organization PROPN I-LF -( PUNCT B-O -WTO PROPN B-AC -) PUNCT B-O -members NOUN B-O -from ADP B-O -January PROPN B-O -1 NUM B-O -, PUNCT B-O -1995 NUM B-O -to ADP B-O -December PROPN B-O -31 NUM B-O -, PUNCT B-O -2016 NUM B-O -. PUNCT B-O - -Severe ADJ B-O -abdominal ADJ B-LF -aortic ADJ I-LF -calcification NOUN I-LF -( PUNCT B-O -AAC PROPN B-AC -) PUNCT B-O -is AUX B-O -associated VERB B-O -with ADP B-O -higher ADJ B-O -risk NOUN B-O -of ADP B-O -cardiovascular ADJ B-O -event NOUN B-O -and CCONJ B-O -of ADP B-O -fragility NOUN B-O -fracture NOUN B-O -. PUNCT B-O - -Oxidative ADJ B-O -stress NOUN B-O -results VERB B-O -in ADP B-O -the DET B-O -generation NOUN B-O -of ADP B-O -excessive ADJ B-O -reactive ADJ B-LF -oxygen NOUN I-LF -species NOUN I-LF -( PUNCT B-O -ROS PROPN B-AC -) PUNCT B-O -and CCONJ B-O -reactive ADJ B-LF -nitrogen NOUN I-LF -species NOUN I-LF -( PUNCT B-O -RNS PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -9–12 NUM B-O -] PUNCT B-O -, PUNCT B-O -which PRON B-O -promotes VERB B-O -the DET B-O -formation NOUN B-O -of ADP B-O -lipid NOUN B-O -peroxides NOUN B-O -and CCONJ B-O -damages VERB B-O -the DET B-O -RNA NOUN B-O -, PUNCT B-O -DNA PROPN B-O -, PUNCT B-O -and CCONJ B-O -proteins NOUN B-O -. PUNCT B-O - -Further ADV B-O -, PUNCT B-O -biological ADJ B-O -samples NOUN B-O -were AUX B-O -often ADV B-O -analyzed VERB B-O -using VERB B-O -nuclear ADJ B-LF -magnetic ADJ I-LF -resonance NOUN I-LF -spectroscopy NOUN B-O -( PUNCT B-O -NMR PROPN B-AC -) PUNCT B-O -as ADP B-O -the DET B-O -only ADJ B-O -analytical ADJ B-O -method NOUN B-O -, PUNCT B-O -data NOUN B-O -analysis NOUN B-O -was AUX B-O -mainly ADV B-O -based VERB B-O -on ADP B-O -principle ADJ B-O -component NOUN B-O -analysis NOUN B-O -( PUNCT B-O -PCA PROPN B-O -) PUNCT B-O -and CCONJ B-O -partial ADJ B-LF -least ADJ I-LF -squares NOUN I-LF -discriminant ADJ B-O -analysis NOUN B-O -( PUNCT B-O -PLS PROPN B-AC -- PUNCT B-O -DA PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -thus ADV B-O -results NOUN B-O -have AUX B-O -been AUX B-O -rather ADV B-O -descriptive ADJ B-O -[ PUNCT B-O -2 NUM B-O -, PUNCT B-O -5 NUM B-O -, PUNCT B-O -16 NUM B-O -, PUNCT B-O -18 NUM B-O -, PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -UHDRS PROPN B-AC -motor NOUN B-O -score NOUN B-O -( PUNCT B-O -A NOUN B-O -) PUNCT B-O -; PUNCT B-O -UHDRS PROPN B-AC -behavioral ADJ B-O -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -, PUNCT B-O -IS PROPN B-AC -: PUNCT B-O -Independence PROPN B-O -Score PROPN B-O -( PUNCT B-O -C PROPN B-O -) PUNCT B-O -; PUNCT B-O -FAS PROPN B-AC -: PUNCT B-O -Functional PROPN B-LF -Assessment PROPN I-LF -Scale PROPN I-LF -( PUNCT B-O -D NOUN B-O -) PUNCT B-O -, PUNCT B-O -cognitive ADJ B-O -( PUNCT B-O -letter NOUN B-O -fluency NOUN B-O -1 NUM B-O -’ PUNCT B-O -: PUNCT B-O -at ADP B-O -1 NUM B-O -minute NOUN B-O -( PUNCT B-O -E NOUN B-O -) PUNCT B-O -; PUNCT B-O -letter NOUN B-O -fluency NOUN B-O -2 NUM B-O -’ PUNCT B-O -: PUNCT B-O -at ADP B-O -2 NUM B-O -minutes NOUN B-O -( PUNCT B-O -F NOUN B-O -) PUNCT B-O -; PUNCT B-O -SDMT PROPN B-AC -: PUNCT B-O -symbol NOUN B-O -digit NOUN B-O -modalities NOUN B-O -test NOUN B-O -( PUNCT B-O -G NOUN B-O -) PUNCT B-O -; PUNCT B-O -Stroop NOUN B-O -C PROPN B-O -: PUNCT B-O -Stroop NOUN B-O -color NOUN B-O -( PUNCT B-O -H NOUN B-O -) PUNCT B-O -; PUNCT B-O -Stroop NOUN B-O -W PROPN B-O -: PUNCT B-O -Stroop NOUN B-O -word NOUN B-O -( PUNCT B-O -I NOUN B-O -) PUNCT B-O -; PUNCT B-O -Stroop NOUN B-O -W PROPN B-O -/ SYM B-O -C PROPN B-O -: PUNCT B-O -Stroop NOUN B-O -interference NOUN B-O -( PUNCT B-O -J NOUN B-O -) PUNCT B-O -. PUNCT B-O - -RR PROPN B-AC -, PUNCT B-O -relative ADJ B-LF -risk NOUN I-LF -. PUNCT B-O - -Dpp PROPN B-AC -, PUNCT B-O -Decapentaplegic PROPN B-LF -; PUNCT B-O -GMR PROPN B-AC -, PUNCT B-O -glass NOUN B-LF -multiple ADJ I-LF -reporter NOUN I-LF -; PUNCT B-O -MF PROPN B-AC -, PUNCT B-O -morphogenetic ADJ B-LF -furrow NOUN I-LF -; PUNCT B-O -rpr PROPN B-O -, PUNCT B-O -reaper NOUN B-O -. PUNCT B-O - -Since SCONJ B-O -a DET B-O -down ADJ B-O -- ADJ B-O -stream NOUN B-O -integrator NOUN B-O -of ADP B-O -metabolic ADJ B-O -alterations NOUN B-O -, PUNCT B-O -mammalian ADJ B-LF -target NOUN I-LF -of ADP I-LF -rapamycin NOUN I-LF -( PUNCT B-O -mTOR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -is AUX B-O -responsible ADJ B-O -for ADP B-O -controlling VERB B-O -the DET B-O -balance NOUN B-O -between ADP B-O -pro ADJ B-O -- ADJ B-O -inflammatory ADJ B-O -interleukin NOUN B-LF -( PUNCT B-O -IL)-12 PROPN B-AC -and CCONJ B-O -anti ADJ B-O -- ADJ B-O -inflammatory ADJ B-O -IL-10 PROPN B-AC -, PUNCT B-O -we PRON B-O -investigated VERB B-O -the DET B-O -effect NOUN B-O -of ADP B-O -upstream ADJ B-O -interference NOUN B-O -using VERB B-O -metabolic ADJ B-O -modulators NOUN B-O -on ADP B-O -the DET B-O -production NOUN B-O -of ADP B-O -pro- ADJ B-O -and CCONJ B-O -anti ADJ B-O -- ADJ B-O -inflammatory ADJ B-O -cytokines NOUN B-O -. PUNCT B-O - -E NOUN B-O -: PUNCT B-O -Representative ADJ B-O -images NOUN B-O -of ADP B-O -hepatic ADJ B-O -hematoxylin NOUN B-O -and CCONJ B-O -eosin NOUN B-O -( PUNCT B-O -H&E PROPN B-O -) PUNCT B-O -, PUNCT B-O -Oil PROPN B-O -Red PROPN B-O -O NOUN B-O -and CCONJ B-O -chloroacetate NOUN B-LF -esterase NOUN I-LF -( PUNCT B-O -CAE PROPN B-AC -) PUNCT B-O -staining NOUN B-O -. PUNCT B-O - -DOTS PROPN B-AC -( PUNCT B-O -directly ADV B-LF -observed VERB I-LF -treatment NOUN I-LF -, PUNCT I-LF -short ADJ I-LF -course NOUN I-LF -) PUNCT B-O -is AUX B-O -the DET B-O -internationally ADV B-O -recommended VERB B-O -control NOUN B-O -strategy NOUN B-O -for ADP B-O -TB PROPN B-AC -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Logistic ADJ B-O -regression NOUN B-O -was AUX B-O -used VERB B-O -to ADP B-O -estimate VERB B-O -the DET B-O -odds NOUN B-LF -ratio NOUN I-LF -( PUNCT B-O -OR PROPN B-AC -) PUNCT B-O -and CCONJ B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-O -interval NOUN B-O -for ADP B-O -the DET B-O -relation NOUN B-O -of ADP B-O -diabetes NOUN B-O -to ADP B-O -the DET B-O -IDE PROPN B-O -genes NOUN B-O -. PUNCT B-O - -Continuous ADJ B-O -variables NOUN B-O -with ADP B-O -normal ADJ B-O -distribution NOUN B-O -are AUX B-O -reported VERB B-O -as ADP B-O -mean NOUN B-O -and CCONJ B-O -standard ADJ B-O -deviation NOUN B-O -and CCONJ B-O -compared VERB B-O -using VERB B-O -analysis NOUN B-LF -of ADP I-LF -variance NOUN I-LF -( PUNCT B-O -ANOVA PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Variables NOUN B-O -without ADP B-O -normal ADJ B-O -distribution NOUN B-O -are AUX B-O -reported VERB B-O -as ADP B-O -median ADJ B-O -and CCONJ B-O -interquartile ADJ B-O -range NOUN B-O -( PUNCT B-O -IQR PROPN B-AC -) PUNCT B-O -and CCONJ B-O -compared VERB B-O -with ADP B-O -Kruskal PROPN B-O -- PUNCT B-O -Wallis PROPN B-O -test NOUN B-O -. PUNCT B-O - -In ADP B-O -contrast NOUN B-O -, PUNCT B-O -significant ADJ B-O -progress NOUN B-O -has AUX B-O -been AUX B-O -made VERB B-O -in ADP B-O -reconstituting VERB B-O -purely ADV B-O -chemical ADJ B-O -reactions NOUN B-O -that PRON B-O -self NOUN B-O -- PUNCT B-O -organise VERB B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -the DET B-O -Belousov PROPN B-O -- PUNCT B-O -Zhabotinski PROPN B-O -reactions NOUN B-O -[ PUNCT B-O -13,14,15 NUM B-O -] PUNCT B-O -and CCONJ B-O -Turing PROPN B-O -- PUNCT B-O -type NOUN B-O -, PUNCT B-O -Meinhardt PROPN B-LF -- PUNCT I-LF -Gierer PROPN I-LF -( PUNCT B-O -M-G PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -oscillatory ADJ B-O -reactions NOUN B-O -[ PUNCT B-O -16,17,18,19,20 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -CI PROPN B-AC -, PUNCT B-O -confidence NOUN B-LF -interval NOUN I-LF -; PUNCT B-O -HR PROPN B-AC -, PUNCT B-O -hazard NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -Ref PROPN B-O -. PUNCT B-O - -, PUNCT B-O -Reference PROPN B-O -category NOUN B-O -We PRON B-O -therefore ADV B-O -aimed VERB B-O -at ADV B-O -exploring VERB B-O -the DET B-O -repertoire NOUN B-O -of ADP B-O -mRNAs NOUN B-O -bound VERB B-O -by ADP B-O -aaRSs PROPN B-AC -. PUNCT B-O - -To ADP B-O -this DET B-O -end NOUN B-O -, PUNCT B-O -we PRON B-O -utilized VERB B-O -yeast NOUN B-O -strains NOUN B-O -expressing VERB B-O -endogenously ADV B-O -, PUNCT B-O -C PROPN B-O -- PUNCT B-O -terminally ADV B-O -Tandem PROPN B-LF -Affinity PROPN I-LF -Purification PROPN I-LF -( PUNCT B-O -methionyl NOUN B-LF -TAP)-tagged PROPN B-AC -- PUNCT I-LF -tRNA NOUN I-LF -synthetase NOUN I-LF -( PUNCT B-O -MetRS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -glutamyl NOUN B-LF -- PUNCT I-LF -tRNA NOUN I-LF -synthetase NOUN I-LF -( PUNCT B-O -GluRS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -valyl NOUN B-LF -- PUNCT I-LF -tRNA NOUN I-LF -synthetase NOUN I-LF -( PUNCT B-O -ValRS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -HisRS PROPN B-AC -or CCONJ B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -GFP)-tagged PROPN B-AC -HisRS PROPN B-AC -and CCONJ B-O -glutamine NOUN B-LF -- PUNCT I-LF -tRNA NOUN I-LF -synthetase NOUN I-LF -( PUNCT B-O -GlnRS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -These DET B-O -aaRSs PROPN B-AC -appeared VERB B-O -to PART B-O -be AUX B-O -associated VERB B-O -with ADP B-O -mRNA NOUN B-O -in ADP B-O -at ADV B-O -least ADV B-O -two NUM B-O -of ADP B-O -the DET B-O -yeast NOUN B-O -interactome NOUN B-O -studies NOUN B-O -( PUNCT B-O -S1 PROPN B-O -Table PROPN B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -contrast NOUN B-O -to ADP B-O -other ADJ B-O -XP PROPN B-AC -patients NOUN B-O -, PUNCT B-O -those PRON B-O -with ADP B-O -the DET B-O -variant NOUN B-O -form NOUN B-O -( PUNCT B-O -XPV PROPN B-AC -) PUNCT B-O -of ADP B-O -Xeroderma PROPN B-LF -Pigmentosum PROPN I-LF -have VERB B-O -no DET B-O -defect NOUN B-O -in ADP B-O -excision NOUN B-O -repair NOUN B-O -[ PUNCT B-O -8 NUM B-O -] PUNCT B-O -, PUNCT B-O -but CCONJ B-O -are AUX B-O -deficient ADJ B-O -in ADP B-O -post ADJ B-O -- ADJ B-O -replication ADJ B-O -repair NOUN B-O -[ PUNCT B-O -23 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Then ADV B-O -, PUNCT B-O -we PRON B-O -selected VERB B-O -the DET B-O -compounds NOUN B-O -library NOUN B-O -which PRON B-O -included VERB B-O -those DET B-O -drug NOUN B-O -classes NOUN B-O -( PUNCT B-O -ZINC15 PROPN B-O -FDA PROPN B-O -- PUNCT B-O -approved VERB B-O -drugs NOUN B-O -) PUNCT B-O -and CCONJ B-O -carried VERB B-O -out ADP B-O -the DET B-O -virtual ADJ B-LF -screening NOUN I-LF -( PUNCT B-O -VS PROPN B-AC -) PUNCT B-O -study NOUN B-O -against ADP B-O -that DET B-O -library NOUN B-O -using VERB B-O -structures NOUN B-O -of ADP B-O -incretin NOUN B-O -receptors NOUN B-O -. PUNCT B-O - -Analytical ADJ B-LF -ultracentrifugation NOUN I-LF -( PUNCT B-O -AUC PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -sedimentation NOUN B-LF -velocity NOUN I-LF -( PUNCT B-O -SV PROPN B-AC -) PUNCT B-O -mode NOUN B-O -was AUX B-O -performed VERB B-O -on ADP B-O -the DET B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -protein NOUN B-O -and CCONJ B-O -all PRON B-O -of ADP B-O -the DET B-O -mutated VERB B-O -proteins NOUN B-O -. PUNCT B-O - -Virus NOUN B-O -titers NOUN B-O -were AUX B-O -determined VERB B-O -by ADP B-O -endpoint NOUN B-O -dilution NOUN B-O -assay NOUN B-O -and CCONJ B-O -calculated VERB B-O -by ADP B-O -the DET B-O -method NOUN B-O -of ADP B-O -Reed PROPN B-O -and CCONJ B-O -Muench PROPN B-O -and CCONJ B-O -expressed VERB B-O -as ADP B-O -50 NUM B-LF -% NOUN I-LF -tissue NOUN I-LF -culture NOUN I-LF -infectious ADJ I-LF -dose NOUN I-LF -( PUNCT B-O -TCID50 PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -53 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Examples NOUN B-O -include VERB B-O -statine NOUN B-LF -( PUNCT B-O -Sta)-containing PROPN B-AC -inhibitors NOUN B-O -and CCONJ B-O -several ADJ B-O -are AUX B-O -now ADV B-O -in ADP B-O -clinical ADJ B-O -use NOUN B-O -[ PUNCT B-O -21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Consistently ADV B-O -, PUNCT B-O -in ADP B-O -pollen NOUN B-O -tubes NOUN B-O -tip NOUN B-O -, PUNCT B-O -ROP PROPN B-AC -/ SYM B-O -RAC PROPN B-O -proteins NOUN B-O -were AUX B-O -shown VERB B-O -to PART B-O -physically ADV B-O -associate VERB B-O -with ADP B-O -a DET B-O -phosphatidylinositol NOUN B-LF -monophosphate NOUN I-LF -kinase NOUN I-LF -( PUNCT B-O -PtdInsP-K PROPN B-AC -) PUNCT B-O -activity NOUN B-O -[ PUNCT B-O -46 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -PtdIns PROPN B-O -- PUNCT B-O -P2 PROPN B-O -, PUNCT B-O -the DET B-O -product NOUN B-O -of ADP B-O -PtdIns PROPN B-AC -, PUNCT B-O -had VERB B-O -similar ADJ B-O -distribution NOUN B-O -[ PUNCT B-O -46],[47 NUM B-O -] PUNCT B-O -. PUNCT B-O - -FLPe PROPN B-O -( PUNCT B-O -Flip)-mediated NOUN B-O -recombination NOUN B-O -resulted VERB B-O -in ADP B-O -a DET B-O -continuous ADJ B-O -reading NOUN B-O -frame NOUN B-O -from ADP B-O -the DET B-O -authentic ADJ B-O -Mll2 NOUN B-O -initiating VERB B-O -codon NOUN B-O -, PUNCT B-O -through ADP B-O -eYFP NOUN B-O -and CCONJ B-O -the DET B-O -residual ADJ B-O -FRT NOUN B-O -to PART B-O -the DET B-O -second ADJ B-O -amino NOUN B-O -acid NOUN B-O -of ADP B-O -Mll2 NOUN B-O -. PUNCT B-O - -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -Mice NOUN B-O -carrying VERB B-O -a DET B-O -single ADJ B-O -copy NOUN B-O -of ADP B-O -Mll2 NOUN B-O -tm2 NOUN B-O -( PUNCT B-O -Mll2 NOUN B-O -tm2/+ NOUN B-O -) PUNCT B-O -were AUX B-O -intercrossed VERB B-O -to PART B-O -obtain VERB B-O -control NOUN B-O -( PUNCT B-O -Mll2 NOUN B-O -+ X B-O -/+and CCONJ B-O -Mll2 NOUN B-O -tm2/+ NOUN B-O -) PUNCT B-O -and CCONJ B-O -experimental ADJ B-O -Mll2 NOUN B-O -tm2 NOUN B-O -/ SYM B-O -tm2 NOUN B-O -mice NOUN B-O -. PUNCT B-O - -( PUNCT B-O -C X B-O -) PUNCT B-O -Southern PROPN B-O -blot NOUN B-O -analysis NOUN B-O -of ADP B-O -tail NOUN B-O -genomic ADJ B-O -DNA NOUN B-O -: PUNCT B-O -a DET B-O -3.8 NUM B-O -kb NOUN B-O -band NOUN B-O -denotes VERB B-O -the DET B-O -Mll2 NOUN B-O -tm2 NOUN B-O -/ SYM B-O -tm2 NOUN B-O -allele NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -a DET B-O -3.0 NUM B-O -kb NOUN B-O -band NOUN B-O -denotes VERB B-O -the DET B-O -wild ADJ B-LF -type NOUN I-LF -( PUNCT B-O -WT PROPN B-AC -) PUNCT B-O -allele NOUN B-O -. PUNCT B-O - -Fewer ADJ B-O -falls NOUN B-O -( PUNCT B-O -incidence NOUN B-LF -rate NOUN I-LF -ratio NOUN I-LF -[ PUNCT B-O -IRR PROPN B-AC -] PUNCT B-O -: PUNCT B-O -0.65 NUM B-O -, PUNCT B-O -0.43–0.99 NUM B-O -; PUNCT B-O -P NOUN B-O -= SYM B-O -0.042 NUM B-O -) PUNCT B-O -were AUX B-O -observed VERB B-O -in ADP B-O -the DET B-O -RESPOND NOUN B-O -group NOUN B-O -compared VERB B-O -with ADP B-O -the DET B-O -control NOUN B-O -( PUNCT B-O -Table PROPN B-O -3 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Cancer NOUN B-O -development NOUN B-O -and CCONJ B-O -tumor NOUN B-O -growth NOUN B-O -are AUX B-O -driven VERB B-O -by ADP B-O -specific ADJ B-O -types NOUN B-O -of ADP B-O -cells NOUN B-O -— PUNCT B-O -stem NOUN B-LF -cell NOUN I-LF -- PUNCT I-LF -like ADJ I-LF -cancer NOUN I-LF -cells NOUN I-LF -( PUNCT B-O -SCLCCs)—which PROPN B-AC -are AUX B-O -also ADV B-O -responsible ADJ B-O -for ADP B-O -metastatic ADJ B-O -spread NOUN B-O -and CCONJ B-O -drug NOUN B-O -resistance NOUN B-O -. PUNCT B-O - -Under ADP B-O -some DET B-O -conditions NOUN B-O -, PUNCT B-O -the DET B-O -C262 PROPN B-O -- PUNCT B-O -S PROPN B-AC -P NOUN B-O -ribozyme NOUN B-LF -E·S·G PROPN B-AC -ternary ADJ B-O -complex NOUN B-O -must AUX B-O -undergo VERB B-O -a DET B-O -rate NOUN B-O -- PUNCT B-O -limiting VERB B-O -conformational ADJ B-O -change NOUN B-O -en ADP B-O -route NOUN B-O -to ADP B-O -the DET B-O -chemical ADJ B-O -transition NOUN B-O -state NOUN B-O -. PUNCT B-O - -To PART B-O -address VERB B-O -these DET B-O -concerns NOUN B-O -, PUNCT B-O -we PRON B-O -propose VERB B-O -a DET B-O -new ADJ B-O -generic ADJ B-O -approach NOUN B-O -for ADP B-O -estimating VERB B-O -the DET B-O -distribution NOUN B-O -of ADP B-O -incident NOUN B-O -infections NOUN B-O -acquired VERB B-O -according VERB B-O -to PART B-O -identifiable ADJ B-O -determinants NOUN B-O -of ADP B-O -risk NOUN B-O -in ADP B-O -the DET B-O -generalised VERB B-O -epidemics NOUN B-O -of ADP B-O -SSA PROPN B-AC -. PUNCT B-O - -The DET B-O -objectives NOUN B-O -of ADP B-O -this DET B-O -study NOUN B-O -were AUX B-O -to PART B-O -( PUNCT B-O -1 X B-O -) PUNCT B-O -describe VERB B-O -the DET B-O -Incidence PROPN B-LF -Patterns PROPN I-LF -Model PROPN I-LF -( PUNCT B-O -IPM PROPN B-AC -) PUNCT B-O -for ADP B-O -SSA PROPN B-AC -, PUNCT B-O -( PUNCT B-O -2 X B-O -) PUNCT B-O -validate VERB B-O -and CCONJ B-O -train VERB B-O -the DET B-O -IPM PROPN B-AC -using VERB B-O -data NOUN B-O -from ADP B-O -cohort NOUN B-O -studies NOUN B-O -in ADP B-O -four NUM B-O -countries NOUN B-O -, PUNCT B-O -( PUNCT B-O -3 X B-O -) PUNCT B-O -apply VERB B-O -the DET B-O -IPM PROPN B-AC -to PART B-O -six NUM B-O -different ADJ B-O -countries NOUN B-O -to PART B-O -show VERB B-O -the DET B-O -predicted VERB B-O -distributions NOUN B-O -of ADP B-O -newly ADV B-O -acquired VERB B-O -HIV PROPN B-O -infections NOUN B-O -in ADP B-O -different ADJ B-O -population NOUN B-O -groups NOUN B-O -, PUNCT B-O -and CCONJ B-O -( PUNCT B-O -4 X B-O -) PUNCT B-O -use VERB B-O -the DET B-O -IPM PROPN B-AC -outputs NOUN B-O -to PART B-O -infer VERB B-O -the DET B-O -distributions NOUN B-O -of ADP B-O -the DET B-O -groups NOUN B-O -transmitting VERB B-O -HIV PROPN B-O -. PUNCT B-O - -The DET B-O -accumulation NOUN B-O -of ADP B-O -TAG PROPN B-AC -- PUNCT B-O -containing VERB B-O -lipid NOUN B-O -droplets NOUN B-O -in ADP B-O -multiple ADJ B-O -tissues NOUN B-O -characteristic ADJ B-O -of ADP B-O -CDS PROPN B-O -has AUX B-O -been AUX B-O -linked VERB B-O -to ADP B-O -impaired ADJ B-O -lipolysis NOUN B-O -caused VERB B-O -by ADP B-O -mutations NOUN B-O -in ADP B-O -comparative ADJ B-LF -gene NOUN I-LF -identification NOUN I-LF -58 NUM I-LF -( PUNCT B-O -CGI-58 PROPN B-AC -; PUNCT B-O -also ADV B-O -called VERB B-O -ABHD5 NOUN B-O -) PUNCT B-O -[ PUNCT B-O -5 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Hepatorenal PROPN B-LF -syndrome NOUN I-LF -( PUNCT B-O -HRS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -most ADV B-O -severe ADJ B-O -form NOUN B-O -of ADP B-O -AKI PROPN B-AC -in ADP B-O -cirrhosis NOUN B-O -, PUNCT B-O -develops VERB B-O -in ADP B-O -more ADJ B-O -than ADP B-O -50 NUM B-O -% NOUN B-O -of ADP B-O -patients NOUN B-O -with ADP B-O -cirrhosis NOUN B-O -who PRON B-O -die VERB B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -PCA PROPN B-AC -, PUNCT B-O -principal ADJ B-LF -component NOUN I-LF -analysis NOUN I-LF -. PUNCT B-O - -BHIS PROPN B-AC -, PUNCT B-O -brain NOUN B-LF -heart NOUN I-LF -infusion NOUN I-LF -plus CCONJ I-LF -yeast NOUN I-LF -; PUNCT B-O -c PROPN B-AC -, PUNCT B-O -cyclic ADJ B-LF -diguanosine NOUN I-LF -monophosphate NOUN I-LF -; PUNCT B-O -cmr NOUN B-O -, PUNCT B-O -colony NOUN B-O -morphology NOUN B-O -regulators NOUN B-O -; PUNCT B-O --di-GMPDccA PROPN B-AC -, PUNCT B-O -diguanylate NOUN B-LF -cyclase NOUN I-LF -A NOUN I-LF -; PUNCT B-O -erm PROPN B-AC -, PUNCT B-O -erythromycin NOUN B-LF -resistance NOUN I-LF -cassette NOUN I-LF -; PUNCT B-O -mut NOUN B-O -, PUNCT B-O -mutant NOUN B-O -; PUNCT B-O -R NOUN B-O -, PUNCT B-O -rough ADJ B-O -; PUNCT B-O -S NOUN B-O -, PUNCT B-O -smooth NOUN B-O -; PUNCT B-O -qPCR PROPN B-AC -, PUNCT B-O -quantitative ADJ B-LF -PCR NOUN I-LF -; PUNCT B-O -qRT PROPN B-AC -, PUNCT B-O -quantitative ADJ B-LF -real ADJ I-LF -- PUNCT I-LF -time NOUN I-LF -PCR NOUN I-LF -; PUNCT B-O -sigD NOUN B-O -, PUNCT B-O -sigma NOUN B-O -factor NOUN B-O -D PROPN B-O -gene NOUN B-O -; PUNCT B-O --PCRTFP PROPN B-AC -, PUNCT B-O -type NOUN B-LF -IV NUM I-LF -pilus NOUN I-LF -. PUNCT B-O - -Interferon PROPN B-LF -( PUNCT B-O -IFN PROPN B-AC -) PUNCT B-O -therapy NOUN B-O -has AUX B-O -been AUX B-O -proved VERB B-O -to PART B-O -achieve VERB B-O -sustained ADJ B-LF -virologic ADJ I-LF -response NOUN I-LF -( PUNCT B-O -SVR PROPN B-AC -) PUNCT B-O -in ADP B-O -patients NOUN B-O -with ADP B-O -chronic ADJ B-O -HCV PROPN B-AC -infection NOUN B-O -and CCONJ B-O -can AUX B-O -prevent VERB B-O -progression NOUN B-O -of ADP B-O -liver NOUN B-O -fibrosis NOUN B-O -. PUNCT B-O - -Thus ADV B-O -, PUNCT B-O -we PRON B-O -expressed VERB B-O -carnitine NOUN B-O -palmitoyltransferase NOUN B-O -1AM PROPN B-O -( PUNCT B-O -CPT1AM PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -permanently ADV B-LF -active ADJ I-LF -mutant ADJ I-LF -form NOUN I-LF -of ADP I-LF -CPT1A PROPN I-LF -CPT1A PROPN B-AC -( PUNCT B-O -the DET B-O -rate NOUN B-O -- PUNCT B-O -limiting VERB B-O -enzyme NOUN B-O -in ADP B-O -FAO PROPN B-AC -) PUNCT B-O -, PUNCT B-O -in ADP B-O -a DET B-O -rat NOUN B-O -brown ADJ B-O -adipocyte NOUN B-O -( PUNCT B-O -rBA PROPN B-AC -) PUNCT B-O -cell NOUN B-O -line NOUN B-O -through ADP B-O -adenoviral ADJ B-O -infection NOUN B-O -. PUNCT B-O - -In ADP B-O -neurons NOUN B-O -, PUNCT B-O -the DET B-O -gp120 PROPN B-O -interaction NOUN B-O -with ADP B-O -CXCR4 PROPN B-AC -enhances VERB B-O -Ca2 NOUN B-O -+ NOUN B-O --regulating VERB B-O -systems NOUN B-O -through ADP B-O -NMDA PROPN B-O -receptors NOUN B-O -( PUNCT B-O -NMDARs PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -synaptic ADJ B-O -membrane NOUN B-O -and CCONJ B-O -inositol NOUN B-O -trisphosphate NOUN B-O -receptors NOUN B-O -( PUNCT B-O -IP3Rs PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -endoplasmic ADJ B-LF -reticulum NOUN I-LF -( PUNCT B-O -ER PROPN B-AC -) PUNCT B-O -, PUNCT B-O -resulting VERB B-O -in ADP B-O -apoptosis NOUN B-O -[ PUNCT B-O -28–34 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Brain NOUN B-LF -– PUNCT I-LF -machine NOUN I-LF -interfaces NOUN I-LF -( PUNCT B-O -BMIs PROPN B-AC -) PUNCT B-O -have VERB B-O -the DET B-O -potential NOUN B-O -to PART B-O -revolutionize VERB B-O -the DET B-O -care NOUN B-O -of ADP B-O -neurologically ADV B-O -impaired ADJ B-O -patients NOUN B-O -. PUNCT B-O - -Antimicrobial ADJ B-LF -peptides NOUN I-LF -( PUNCT B-O -AMPs PROPN B-AC -) PUNCT B-O -play VERB B-O -a DET B-O -key ADJ B-O -role NOUN B-O -in ADP B-O -innate ADJ B-O -immune ADJ B-O -response NOUN B-O -against ADP B-O -bacteria NOUN B-O -, PUNCT B-O -viruses NOUN B-O -, PUNCT B-O -fungi NOUN B-O -, PUNCT B-O -and CCONJ B-O -parasites NOUN B-O -[ PUNCT B-O -20,21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -FFR PROPN B-AC -, PUNCT B-O -fractional ADJ B-LF -flow NOUN I-LF -reserve NOUN I-LF -. PUNCT B-O - -Co ADJ B-O -- PUNCT B-O -primary ADJ B-O -short- ADJ B-O -and CCONJ B-O -long ADJ B-O -- PUNCT B-O -term NOUN B-O -outcomes NOUN B-O -were AUX B-O -1 NUM B-O -- PUNCT B-O -year NOUN B-O -total ADJ B-LF -kidney NOUN I-LF -volume NOUN I-LF -( PUNCT B-O -TKV PROPN B-AC -) PUNCT B-O -( PUNCT B-O -computed ADJ B-O -tomography NOUN B-O -scan NOUN B-O -) PUNCT B-O -growth NOUN B-O -and CCONJ B-O -3 NUM B-O -- PUNCT B-O -year NOUN B-O -GFR PROPN B-AC -( PUNCT B-O -iohexol NOUN B-O -plasma NOUN B-O -clearance NOUN B-O -) PUNCT B-O -decline NOUN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -HEI PROPN B-AC -, PUNCT B-O -Healthy PROPN B-LF -Eating PROPN I-LF -Index PROPN I-LF -; PUNCT B-O -Q NOUN B-O -, PUNCT B-O -quartile NOUN B-O -. PUNCT B-O - -Indeed ADV B-O -, PUNCT B-O -discrimination NOUN B-O -of ADP B-O -the DET B-O -mother NOUN B-O -and CCONJ B-O -daughter NOUN B-O -using VERB B-O -CEP164 PROPN B-O -immunostaining NOUN B-O -showed VERB B-O -that SCONJ B-O -roots NOUN B-O -are AUX B-O -nucleated VERB B-O -symmetrically ADV B-O -on ADP B-O -both CCONJ B-O -mother NOUN B-O -and CCONJ B-O -daughter NOUN B-O -( PUNCT B-O -Fig NOUN B-O -4B NUM B-O -) PUNCT B-O -. PUNCT B-O - -A DET B-O -similar ADJ B-O -comparison NOUN B-O -of ADP B-O -PCM PROPN B-AC -structure NOUN B-O -with ADP B-O -the DET B-O -PCM PROPN B-AC -resident NOUN B-O -Pericentrin PROPN B-LF -( PUNCT B-O -PCNT PROPN B-AC -) PUNCT B-O -showed VERB B-O -similarly ADV B-O -that SCONJ B-O -both CCONJ B-O -mother NOUN B-O -and CCONJ B-O -daughter NOUN B-O -centrioles NOUN B-O -individually ADV B-O -nucleate VERB B-O -PCM PROPN B-AC -when SCONJ B-O -split VERB B-O -( PUNCT B-O -Fig NOUN B-O -4C NUM B-O -) PUNCT B-O -, PUNCT B-O -something PRON B-O -also ADV B-O -evident ADJ B-O -in ADP B-O -the DET B-O -live ADJ B-O -- PUNCT B-O -cell NOUN B-O -imaging NOUN B-O -of ADP B-O -NEDD1 PROPN B-AC -- PUNCT B-O -mRuby3 PROPN B-O -( PUNCT B-O -Fig NOUN B-O -3H–3 NUM B-O -K NUM B-O -) PUNCT B-O -and CCONJ B-O -previous ADJ B-O -work NOUN B-O -[ X B-O -24,32,34 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Water NOUN B-O -deficit NOUN B-O -was AUX B-O -initiated VERB B-O -when SCONJ B-O -seedlings NOUN B-O -were AUX B-O -almost ADV B-O -20 NUM B-O -day NOUN B-O -- PUNCT B-O -old ADJ B-O -, PUNCT B-O -attaining VERB B-O -2–3 NUM B-O -true ADJ B-O -leaves NOUN B-O -and CCONJ B-O -it PRON B-O -was AUX B-O -applied VERB B-O -by ADP B-O -maintaining VERB B-O -the DET B-O -soil NOUN B-O -moisture NOUN B-O -at ADP B-O -40 NUM B-O -% NOUN B-O -of ADP B-O -substrate NOUN B-O -field NOUN B-LF -capacity NOUN I-LF -( PUNCT B-O -FC PROPN B-AC -) PUNCT B-O -for ADP B-O -the DET B-O -stressed VERB B-O -plants NOUN B-O -, PUNCT B-O -and CCONJ B-O -80 NUM B-O -% NOUN B-O -FC PROPN B-AC -for ADP B-O -the DET B-O -well ADV B-O -- PUNCT B-O -watered VERB B-O -plants NOUN B-O -. PUNCT B-O - -It PRON B-O -would AUX B-O -be AUX B-O -worth ADJ B-O -noting VERB B-O -that PRON B-O -the DET B-O -clustered VERB B-O -lysine NOUN B-O -residues NOUN B-O -that PRON B-O -we PRON B-O -found VERB B-O -as ADP B-O -TMP195 NOUN B-O -- ADJ B-O -sensitive ADJ B-O -acetylation NOUN B-O -sites NOUN B-O -were AUX B-O -located VERB B-O -in ADP B-O -the DET B-O -N NOUN B-O -- ADJ B-O -terminal ADJ B-O -intrinsically ADV B-LF -disordered VERB I-LF -region NOUN I-LF -( PUNCT B-O -IDR PROPN B-AC -) PUNCT B-O -of ADP B-O -NCL PROPN B-AC -( PUNCT B-O -S7C PROPN B-O -Fig PROPN B-O -) PUNCT B-O -[ PUNCT B-O -87 NUM B-O -] PUNCT B-O -. PUNCT B-O - -They PRON B-O -recognize VERB B-O -bacterial ADJ B-O -surface NOUN B-O -molecules NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -lipopolysaccharides NOUN B-O -( PUNCT B-O -LPS PROPN B-AC -) PUNCT B-O -from ADP B-O -the DET B-O -outer ADJ B-O -wall NOUN B-O -of ADP B-O -Gram NOUN B-O -- PUNCT B-O -negative ADJ B-O -bacteria NOUN B-O -and CCONJ B-O -flagellin NOUN B-LF -( PUNCT B-O -FLG PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -a DET B-O -structural ADJ B-O -protein NOUN B-O -of ADP B-O -flagellum NOUN B-O -, PUNCT B-O -a DET B-O -bacterial ADJ B-O -locomotive NOUN B-O -organelle NOUN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -OR PROPN B-AC -: PUNCT B-O -odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -CI PROPN B-AC -: PUNCT B-O -confidence NOUN B-O -interval NOUN B-O -. PUNCT B-O - -MOI PROPN B-AC -represents VERB B-O -the DET B-O -multiplicity NOUN B-LF -of ADP I-LF -infection NOUN I-LF -. PUNCT B-O - -Both DET B-O -domains NOUN B-O -share VERB B-O -approximately ADV B-O -9 NUM B-O -% NOUN B-O -sequence NOUN B-O -identity NOUN B-O -and CCONJ B-O -can AUX B-O -be AUX B-O -superimposed VERB B-O -with ADP B-O -a DET B-O -root NOUN B-LF -mean ADJ I-LF -square ADJ I-LF -( PUNCT B-O -rms PROPN B-AC -) PUNCT B-O -deviation NOUN B-O -of ADP B-O -2.4 NUM B-O -Å NOUN B-O -using VERB B-O -101 NUM B-O -Cα NOUN B-O -- NOUN B-O -atoms NOUN B-O -out ADP B-O -of ADP B-O -153 NUM B-O -from ADP B-O -domain NOUN B-O -1 NUM B-O -, PUNCT B-O -and CCONJ B-O -201 NUM B-O -from ADP B-O -domain NOUN B-O -4 NUM B-O -, PUNCT B-O -respectively ADV B-O -. PUNCT B-O - -The DET B-O -study NOUN B-O -was AUX B-O -carried VERB B-O -out ADP B-O -in ADP B-O -collaboration NOUN B-O -with ADP B-O -the DET B-O -Swiss PROPN B-LF -Childhood PROPN I-LF -Cancer PROPN I-LF -Registry PROPN I-LF -( PUNCT B-O -SCCR PROPN B-AC -, PUNCT B-O -www.childhoodcancerregistry.ch X B-O -) PUNCT B-O -, PUNCT B-O -which PRON B-O -, PUNCT B-O -since SCONJ B-O -1976 NUM B-O -, PUNCT B-O -has AUX B-O -included VERB B-O -all DET B-O -children NOUN B-O -and CCONJ B-O -adolescents NOUN B-O -in ADP B-O -Switzerland PROPN B-O -diagnosed VERB B-O -with ADP B-O -leukemia NOUN B-O -, PUNCT B-O -lymphoma NOUN B-O -, PUNCT B-O -central ADJ B-LF -nervous ADJ I-LF -system NOUN I-LF -( PUNCT B-O -CNS PROPN B-AC -) PUNCT B-O -tumors NOUN B-O -, PUNCT B-O -malignant ADJ B-O -solid ADJ B-O -tumors NOUN B-O -and CCONJ B-O -Langerhans PROPN B-LF -cell NOUN I-LF -histiocytosis NOUN I-LF -( PUNCT B-O -LCH PROPN B-AC -) PUNCT B-O -before SCONJ B-O -they PRON B-O -were AUX B-O -21 NUM B-O -[ PUNCT B-O -17 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Yunnan PROPN B-O -province NOUN B-O -itself PRON B-O -has VERB B-O -a DET B-O -large ADJ B-O -population NOUN B-O -of ADP B-O -people NOUN B-LF -who PRON I-LF -inject VERB I-LF -drugs NOUN I-LF -( PUNCT B-O -PWID PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -15 NUM B-O -, PUNCT B-O -16 NUM B-O -] PUNCT B-O -. PUNCT B-O - -possibly ADV B-O -due ADP B-O -to ADP B-O -Yunnan PROPN B-O -’s PART B-O -position NOUN B-O -along ADP B-O -key ADJ B-O -heroin NOUN B-O -trafficking NOUN B-O -routes NOUN B-O -into ADP B-O -China PROPN B-O -[ PUNCT B-O -17 NUM B-O -, PUNCT B-O -18 NUM B-O -] PUNCT B-O -. PUNCT B-O - -A3A PROPN B-AC -, PUNCT B-O -APOBEC3A. PROPN B-LF -Serial ADJ B-O -10 NUM B-O -- PUNCT B-O -fold ADJ B-O -dilution NOUN B-O -from ADP B-O -indicated VERB B-O -strains NOUN B-O -spotted VERB B-O -onto ADP B-O -media NOUN B-O -containing VERB B-O -indicated VERB B-O -hydroxyurea NOUN B-LF -( PUNCT B-O -HU PROPN B-AC -, PUNCT B-O -top ADJ B-O -panel NOUN B-O -) PUNCT B-O -or CCONJ B-O -camptothecin NOUN B-LF -( PUNCT B-O -CPT PROPN B-AC -, PUNCT B-O -bottom ADJ B-O -panel NOUN B-O -) PUNCT B-O -concentration NOUN B-O -. PUNCT B-O - -The DET B-O -complete ADJ B-O -results NOUN B-O -for ADP B-O -two NUM B-O -distinct ADJ B-O -diplococci NOUN B-O -( PUNCT B-O -no NOUN B-O -. PUNCT B-O - -109 NUM B-O -and CCONJ B-O -no NOUN B-O -. PUNCT B-O - -110 NUM B-O -) PUNCT B-O -are AUX B-O -presented VERB B-O -in ADP B-O -Figure PROPN B-O -S3 NUM B-O -. PUNCT B-O - -The DET B-O -position NOUN B-O -coordinates NOUN B-O -of ADP B-O -individual ADJ B-O -diplococci NOUN B-O -mounted VERB B-O -on ADP B-O -formvar NOUN B-O -- NOUN B-O -coated VERB B-O -gold NOUN B-O -TEM PROPN B-AC -grids NOUN B-O -were AUX B-O -determined VERB B-O -by ADP B-O -light NOUN B-LF -microscopy NOUN I-LF -( PUNCT B-O -LM PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -TEM PROPN B-AC -grids NOUN B-O -were AUX B-O -subsequently ADV B-O -placed VERB B-O -in ADP B-O -the DET B-O -focal ADJ B-O -plane NOUN B-O -of ADP B-O -the DET B-O -X NOUN B-O -- NOUN B-O -ray NOUN B-O -optic NOUN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -grid NOUN B-O -markers NOUN B-O -were AUX B-O -used VERB B-O -to PART B-O -locate VERB B-O -the DET B-O -targeted VERB B-O -cells NOUN B-O -. PUNCT B-O - -Because SCONJ B-O -PMNs PROPN B-AC -adhere VERB B-O -to ADP B-O -plates NOUN B-O -after ADP B-O -activation NOUN B-O -, PUNCT B-O -the DET B-O -use NOUN B-O -of ADP B-O -counting NOUN B-O -by ADP B-O -flow NOUN B-O -cytometry NOUN B-O -was AUX B-O -ineffective ADJ B-O -for ADP B-O -determining VERB B-O -viability NOUN B-O -, PUNCT B-O -and CCONJ B-O -instead ADV B-O -viability NOUN B-O -was AUX B-O -assessed VERB B-O -using VERB B-O -cytosolic ADJ B-O -mammalian ADJ B-O -- PUNCT B-O -specific ADJ B-O -lactate NOUN B-LF -dehydrogenase NOUN I-LF -( PUNCT B-O -LDH PROPN B-AC -) PUNCT B-O -detection NOUN B-O -in ADP B-O -supernatants NOUN B-O -using VERB B-O -the DET B-O -CytoTox PROPN B-O -- PUNCT B-O -One NUM B-O -homogeneous ADJ B-O -membrane NOUN B-O -integrity NOUN B-O -assay NOUN B-O -( PUNCT B-O -Promega PROPN B-O -, PUNCT B-O -Madison PROPN B-O -, PUNCT B-O -WI PROPN B-O -) PUNCT B-O -as SCONJ B-O -described VERB B-O -[ PUNCT B-O -27 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -on ADP B-O -sow NOUN B-O -, PUNCT B-O -piglet NOUN B-O -, PUNCT B-O -weaner NOUN B-O -and CCONJ B-O -fattening NOUN B-O -pig NOUN B-O -holdings NOUN B-O -were AUX B-O -described VERB B-O -separately ADV B-O -, PUNCT B-O -using VERB B-O -the DET B-O -semi ADJ B-O -- ADJ B-O -annual ADJ B-O -treatment NOUN B-LF -frequency NOUN I-LF -( PUNCT B-O -TF PROPN B-AC -) PUNCT B-O -to PART B-O -measure VERB B-O -antibiotic ADJ B-O -consumption NOUN B-O -. PUNCT B-O - -MHC PROPN B-AC -, PUNCT B-O -major ADJ B-LF -histocompatibility NOUN I-LF -complex NOUN I-LF -. PUNCT B-O - -Many ADJ B-O -activation NOUN B-O -events NOUN B-O -downstream ADV B-O -of ADP B-O -the DET B-O -T NOUN B-LF -- PUNCT I-LF -cell NOUN I-LF -antigen NOUN I-LF -receptor NOUN I-LF -( PUNCT B-O -TCR PROPN B-AC -) PUNCT B-O -are AUX B-O -up ADV B-O -- PUNCT B-O -regulated VERB B-O -by ADP B-O -the DET B-O -nuclear ADJ B-LF -factor NOUN I-LF -of ADP I-LF -activated VERB I-LF -T NOUN I-LF -cells NOUN I-LF -( PUNCT B-O -NFAT PROPN B-AC -) PUNCT B-O -transcription NOUN B-O -factor NOUN B-O -family NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -copy NOUN B-LF -number NOUN I-LF -variation NOUN I-LF -( PUNCT B-O -CNV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -well ADV B-O -- ADJ B-O -established VERB B-O -source NOUN B-O -of ADP B-O -inter ADJ B-O -- ADJ B-O -individual ADJ B-O -genetic ADJ B-O -variation NOUN B-O -[ X B-O -5 NUM B-O -, PUNCT B-O -13 NUM B-O -, PUNCT B-O -14 NUM B-O -] PUNCT B-O -has AUX B-O -also ADV B-O -been AUX B-O -reported VERB B-O -to PART B-O -target VERB B-O -several ADJ B-O -FcγR PROPN B-AC -genes NOUN B-O -and CCONJ B-O -can AUX B-O -alter VERB B-O -surface NOUN B-O -FcγR PROPN B-AC -protein NOUN B-O -expression NOUN B-O -and CCONJ B-O -cellular ADJ B-O -function NOUN B-O -[ X B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Humoral ADJ B-O -allo ADJ B-O -- PUNCT B-O -immune ADJ B-O -responses NOUN B-O -mediated VERB B-O -by ADP B-O -donor NOUN B-LF -- PUNCT I-LF -specific ADJ I-LF -antibodies NOUN I-LF -( PUNCT B-O -DSA PROPN B-AC -) PUNCT B-O -is AUX B-O -now ADV B-O -well ADV B-O -recognized VERB B-O -as ADP B-O -a DET B-O -detrimental ADJ B-O -determinant NOUN B-O -of ADP B-O -graft NOUN B-O -outcome NOUN B-O -after ADP B-O -solid ADJ B-O -organ NOUN B-O -transplantation NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -USP6 PROPN B-O -transgenic VERB B-O -mice NOUN B-O -exhibited VERB B-O -enhanced ADJ B-O -learning NOUN B-O -and CCONJ B-O -memory NOUN B-O -behavior NOUN B-O -in ADP B-O -Morris PROPN B-LF -water PROPN I-LF -maze PROPN I-LF -( PUNCT B-O -MWM PROPN B-AC -) PUNCT B-O -and CCONJ B-O -novel ADJ B-LF -object NOUN I-LF -recognition NOUN I-LF -( PUNCT B-O -NOR PROPN B-AC -) PUNCT B-O -tests NOUN B-O -. PUNCT B-O - -Tether NOUN B-O -proteins NOUN B-O -attach VERB B-O -the DET B-O -endoplasmic ADJ B-LF -reticulum NOUN I-LF -( PUNCT B-O -ER PROPN B-AC -) PUNCT B-O -to PART B-O -other ADJ B-O -cellular ADJ B-O -membranes NOUN B-O -, PUNCT B-O -thereby ADV B-O -creating VERB B-O -contact NOUN B-O -sites NOUN B-O -that PRON B-O -are AUX B-O -proposed VERB B-O -to PART B-O -form VERB B-O -platforms NOUN B-O -for ADP B-O -regulating VERB B-O -lipid NOUN B-O -homeostasis NOUN B-O -and CCONJ B-O -facilitating VERB B-O -non ADJ B-O -- ADJ B-O -vesicular ADJ B-O -lipid NOUN B-O -exchange NOUN B-O -. PUNCT B-O - -Oral ADJ B-LF -cholera NOUN I-LF -vaccine NOUN I-LF -( PUNCT B-O -OCV PROPN B-AC -) PUNCT B-O -plays VERB B-O -a DET B-O -key ADJ B-O -role NOUN B-O -in ADP B-O -reducing VERB B-O -the DET B-O -near ADJ B-O -- PUNCT B-O -term NOUN B-O -risk NOUN B-O -of ADP B-O -cholera NOUN B-O -, PUNCT B-O -although SCONJ B-O -global ADJ B-O -supplies NOUN B-O -are AUX B-O -limited ADJ B-O -. PUNCT B-O - -Emitted VERB B-O -photons NOUN B-O -were AUX B-O -detected VERB B-O -with ADP B-O -a DET B-O -single ADJ B-LF -- PUNCT I-LF -photon NOUN I-LF -avalanche NOUN I-LF -diode NOUN I-LF -( PUNCT B-O -SPAD PROPN B-AC -) PUNCT B-O -detector NOUN B-O -( PUNCT B-O -SPCM PROPN B-O -CD3516H PROPN B-O -; PUNCT B-O -Excelitas PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -a DET B-O -time NOUN B-O -- PUNCT B-O -correlated VERB B-O -single ADJ B-O -- PUNCT B-O -photon NOUN B-O -counting VERB B-O -unit NOUN B-O -( PUNCT B-O -HydraHarp PROPN B-O -400 NUM B-O -; PUNCT B-O -PicoQuant PROPN B-O -) PUNCT B-O -was AUX B-O -used VERB B-O -to PART B-O -generate VERB B-O -picosecond NOUN B-O -histograms NOUN B-O -( PUNCT B-O -16 NUM B-O -ps NOUN B-O -resolution NOUN B-O -) PUNCT B-O -from ADP B-O -the DET B-O -photon NOUN B-O -arrival NOUN B-O -times NOUN B-O -. PUNCT B-O - -TBB PROPN B-AC -is AUX B-O -a DET B-O -selective ADJ B-O -, PUNCT B-O -cell NOUN B-O -- PUNCT B-O -permeable ADJ B-O -, PUNCT B-O -ATP PROPN B-O -/ SYM B-O -GTP NOUN B-O -- PUNCT B-O -competitive ADJ B-O -inhibitor NOUN B-O -of ADP B-O -casein NOUN B-LF -kinase NOUN I-LF -II NUM I-LF -( PUNCT B-O -CKII PROPN B-AC -) PUNCT B-O -( PUNCT B-O -IC50 NUM B-O -= SYM B-O -900 NUM B-O -nM NOUN B-O -for ADP B-O -rat ADJ B-O -liver NOUN B-O -) PUNCT B-O -[ PUNCT B-O -124 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Berberine PROPN B-LF -( PUNCT B-O -BBR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -an DET B-O -isoquinoline NOUN B-O -alkaloid NOUN B-O -isolated VERB B-O -from ADP B-O -many ADJ B-O -medicinal ADJ B-O -herbs NOUN B-O -, PUNCT B-O -is AUX B-O -one NUM B-O -of ADP B-O -the DET B-O -widely ADV B-O -used VERB B-O -traditional ADJ B-O -Chinese ADJ B-O -medicines NOUN B-O -and CCONJ B-O -has AUX B-O -been AUX B-O -used VERB B-O -to PART B-O -treat VERB B-O -various ADJ B-O -infectious ADJ B-O -disorders NOUN B-O -for ADP B-O -more ADJ B-O -than ADP B-O -3,000 NUM B-O -years NOUN B-O -[ PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Lower ADJ B-LF -limit NOUN I-LF -of ADP I-LF -quantitation NOUN I-LF -( PUNCT B-O -LLoQ PROPN B-AC -) PUNCT B-O -and CCONJ B-O -limit NOUN B-LF -of ADP I-LF -detection NOUN I-LF -( PUNCT B-O -LoD PROPN B-AC -) PUNCT B-O -were AUX B-O -determined VERB B-O -by ADP B-O -measurement NOUN B-O -precision NOUN B-O -using VERB B-O -serial ADJ B-O -dilutions NOUN B-O -of ADP B-O -LAM PROPN B-AC -extracts NOUN B-O -obtained VERB B-O -from ADP B-O -M. PROPN B-O -bovis PROPN B-O -Bacillus PROPN B-O -Calmette PROPN B-O -- PUNCT B-O -Guérin PROPN B-O -Tokyo PROPN B-O -( PUNCT B-O -BCG PROPN B-AC -) PUNCT B-O -culture NOUN B-O -. PUNCT B-O - -Before ADP B-O -dissociation NOUN B-O -of ADP B-O -C120 PROPN B-O -from ADP B-O -Z775mAG PROPN B-O -, PUNCT B-O -the DET B-O -head NOUN B-LF -- PUNCT I-LF -to ADP I-LF -- PUNCT I-LF -head NOUN I-LF -distance NOUN I-LF -( PUNCT B-O -i.e. X B-O -, PUNCT B-O -the DET B-O -distance NOUN B-O -between ADP B-O -the DET B-O -centers NOUN B-O -of ADP B-O -mass NOUN B-O -of ADP B-O -ZEN-4 NOUN B-O -motor NOUN B-O -domains NOUN B-O -[ X B-O -DH-H PROPN B-AC -] PUNCT B-O -) PUNCT B-O -was AUX B-O -12 NUM B-O -± SYM B-O -3 NUM B-O -nm NOUN B-O -( PUNCT B-O -mean ADJ B-O -± SYM B-O -SD NOUN B-O -) PUNCT B-O -, PUNCT B-O -whereas SCONJ B-O -, PUNCT B-O -after ADP B-O -dissociation NOUN B-O -, PUNCT B-O -the DET B-O -mean ADJ B-O -DH PROPN B-AC -increased VERB B-O -to ADP B-O -16 NUM B-O -nm NOUN B-O -, PUNCT B-O -with ADP B-O -a DET B-O -larger ADJ B-O -standard ADJ B-O -deviation NOUN B-O -of ADP B-O -6 NUM B-O -nm NOUN B-O -( PUNCT B-O -Fig PROPN B-O -6D NUM B-O -and CCONJ B-O -6E NUM B-O -; PUNCT B-O -for ADP B-O -additional ADJ B-O -movies NOUN B-O -and CCONJ B-O -head NOUN B-LF -- PUNCT I-LF -to ADP I-LF -- PUNCT I-LF -head NOUN I-LF -distance NOUN I-LF -measurements NOUN B-O -, PUNCT B-O -S11 PROPN B-O -Movie PROPN B-O -and CCONJ B-O -S4A PROPN B-O -– PUNCT B-O -S4C PROPN B-O -Fig PROPN B-O -, PUNCT B-O -respectively ADV B-O -) PUNCT B-O -. PUNCT B-O - -Of ADP B-O -855,046 NUM B-O -sequences NOUN B-O -, PUNCT B-O -417,953 NUM B-O -with ADP B-O -useable ADJ B-O -reads NOUN B-O -were AUX B-O -assignable ADJ B-O -to ADP B-O -93 NUM B-O -operational ADJ B-LF -taxonomic ADJ I-LF -units NOUN I-LF -( PUNCT B-O -OTUs PROPN B-AC -) PUNCT B-O -consisting VERB B-O -of ADP B-O -80 NUM B-O -OTUs PROPN B-AC -of ADP B-O -bacteria NOUN B-O -, PUNCT B-O -12 NUM B-O -OTUs PROPN B-AC -of ADP B-O -hamster NOUN B-O -DNA NOUN B-O -, PUNCT B-O -and CCONJ B-O -one NUM B-O -OTU PROPN B-AC -of ADP B-O -plant NOUN B-O -origin NOUN B-O -. PUNCT B-O - -A DET B-O -1.0 NUM B-O -m NOUN B-O -above ADP B-LF -- PUNCT I-LF -ground NOUN I-LF -biomass NOUN I-LF -( PUNCT B-O -AGBM PROPN B-AC -) PUNCT B-O -sample NOUN B-O -was AUX B-O -cut VERB B-O -from ADP B-O -the DET B-O -center NOUN B-O -row NOUN B-O -of ADP B-O -each DET B-O -plot NOUN B-O -at ADP B-O -harvest NOUN B-O -maturity NOUN B-O -( PUNCT B-O -grain NOUN B-O -moisture NOUN B-O -concentration NOUN B-O -≤ PUNCT B-O -160 NUM B-O -g NOUN B-O -kg-1 NUM B-O -) PUNCT B-O -in ADP B-O -all DET B-O -testing NOUN B-O -environments NOUN B-O -. PUNCT B-O - -Cathepsin PROPN B-LF -D PROPN I-LF -( PUNCT B-O -CD PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -lysosomal ADJ B-O -protease NOUN B-O -previously ADV B-O -demonstrated VERB B-O -to PART B-O -cleave VERB B-O -α PUNCT B-O -- NOUN B-O -syn NOUN B-O -and CCONJ B-O -decrease VERB B-O -its PRON B-O -toxicity NOUN B-O -in ADP B-O -cell NOUN B-O -lines NOUN B-O -[ PUNCT B-O -18 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This PRON B-O -is AUX B-O -promising ADJ B-O -especially ADV B-O -concerning VERB B-O -cardiomyocyte NOUN B-O -damage NOUN B-O -following VERB B-O -myocardial ADJ B-LF -infarction NOUN I-LF -( PUNCT B-O -MI PROPN B-AC -) PUNCT B-O -or CCONJ B-O -heart NOUN B-O -failure NOUN B-O -in ADP B-O -CVD PROPN B-AC -patients NOUN B-O -. PUNCT B-O - -Liver PROPN B-O -disease NOUN B-O -severity NOUN B-O -was AUX B-O -assessed VERB B-O -using VERB B-O -the DET B-O -Child PROPN B-LF -Pugh PROPN I-LF -Score PROPN I-LF -( PUNCT B-O -CPS PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Model PROPN B-LF -for ADP I-LF -End PROPN I-LF -- PUNCT I-LF -stage NOUN I-LF -Liver PROPN I-LF -Disease PROPN I-LF -( PUNCT B-O -MELD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -medical ADJ B-O -comorbidities NOUN B-O -were AUX B-O -assessed VERB B-O -using VERB B-O -the DET B-O -Charlson PROPN B-LF -Comorbidity PROPN I-LF -Index PROPN I-LF -( PUNCT B-O -CCI PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -11 NUM B-O -] PUNCT B-O -. PUNCT B-O - -An DET B-O -analysis NOUN B-O -of ADP B-O -microtubule NOUN B-LF -associated VERB I-LF -protein NOUN I-LF -2 NUM I-LF -( PUNCT B-O -MAP2)- PROPN B-AC -and CCONJ B-O -Nissl PROPN B-O -- ADJ B-O -stained VERB B-O -Ngl3−/− PROPN B-O -slices NOUN B-O -revealed VERB B-O -that SCONJ B-O -the DET B-O -gross ADJ B-O -morphology NOUN B-O -of ADP B-O -the DET B-O -Ngl3−/−(Hyb PROPN B-O -) PUNCT B-O -brain NOUN B-O -was AUX B-O -largely ADV B-O -normal ADJ B-O -, PUNCT B-O -except SCONJ B-O -for ADP B-O -an DET B-O -apparent ADJ B-O -decrease NOUN B-O -in ADP B-O -the DET B-O -size NOUN B-O -of ADP B-O -the DET B-O -thalamus NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1F NUM B-O -and CCONJ B-O -1 NUM B-O -G NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Levels NOUN B-O -of ADP B-O -NGL-3 PROPN B-AC -relatives NOUN B-O -( PUNCT B-O -NGL-1 PROPN B-O -and CCONJ B-O -NGL-2 PROPN B-O -) PUNCT B-O -were AUX B-O -normal ADJ B-O -in ADP B-O -the DET B-O -Ngl3−/−(Hyb PROPN B-O -) PUNCT B-O -brains NOUN B-O -( PUNCT B-O -3 NUM B-O -and CCONJ B-O -10 NUM B-O -weeks NOUN B-O -) PUNCT B-O -, PUNCT B-O -although SCONJ B-O -levels NOUN B-O -of ADP B-O -PTPδ PROPN B-AC -, PUNCT B-O -a DET B-O -trans ADJ B-O -- ADJ B-O -synaptic ADJ B-O -partner NOUN B-O -of ADP B-O -NGL-3 PROPN B-AC -, PUNCT B-O -were AUX B-O -reduced VERB B-O -( PUNCT B-O -S2 PROPN B-O -Fig PROPN B-O -) PUNCT B-O -. PUNCT B-O - -IFOF PROPN B-AC -, PUNCT B-O -inferior ADJ B-LF -fronto ADJ I-LF -- PUNCT I-LF -occipital ADJ I-LF -fascicle NOUN I-LF -; PUNCT B-O -ILF PROPN B-AC -, PUNCT B-O -inferior ADJ B-LF -longitudinal ADJ I-LF -fascicle NOUN I-LF -; PUNCT B-O -ILFlat PROPN B-AC -, PUNCT B-O -inferior ADJ B-LF -longitudinal ADJ I-LF -fascicle NOUN I-LF -lateral ADJ B-O -; PUNCT B-O -ILFmed PROPN B-AC -, PUNCT B-O -inferior ADJ B-LF -longitudinal ADJ I-LF -fascicle NOUN I-LF -medial ADJ B-O -; PUNCT B-O -MdLF PROPN B-AC -, PUNCT B-O -middle ADJ B-LF -longitudinal ADJ I-LF -fascicle NOUN I-LF -; PUNCT B-O -PRIME PROPN B-O -- PUNCT B-O -DE PROPN B-O -, PUNCT B-O -Primate PROPN B-O -Data PROPN B-O -Exchange PROPN B-O -. PUNCT B-O - -Recent ADJ B-O -work NOUN B-O -suggests VERB B-O -that SCONJ B-O -a DET B-O -T NOUN B-O -cell NOUN B-O -- PUNCT B-O -based VERB B-O -assay NOUN B-O -for ADP B-O -interferon NOUN B-O -gamma NOUN B-O -, PUNCT B-O -the DET B-O -enzyme NOUN B-LF -- PUNCT I-LF -linked VERB I-LF -immunosorbent ADJ I-LF -spot NOUN I-LF -test NOUN I-LF -( PUNCT B-O -ELISPOT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -has VERB B-O -promise NOUN B-O -in ADP B-O -the DET B-O -diagnosis NOUN B-O -of ADP B-O -Mycobacterium PROPN B-O -tuberculosis NOUN B-LF -infection NOUN B-O -after ADP B-O -exposure NOUN B-O -to ADP B-O -a DET B-O -known VERB B-O -tuberculosis NOUN B-LF -( PUNCT B-O -TB PROPN B-AC -) PUNCT B-O -patient NOUN B-O -[ X B-O -1–3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -NB PROPN B-O -: PUNCT B-O -GLIA PROPN B-AC -: PUNCT B-O -Guideline PROPN B-LF -Implementability PROPN I-LF -Appraisal PROPN I-LF -, PUNCT B-O -SD PROPN B-O -: PUNCT B-O -standard ADJ B-O -deviation NOUN B-O -, PUNCT B-O -% NOUN B-O -age NOUN B-O -score NOUN B-O -: PUNCT B-O -percentage NOUN B-O -score NOUN B-O -EF PROPN B-O -– PUNCT B-O -Ejection PROPN B-O -Fraction PROPN B-O -, PUNCT B-O -EDV PROPN B-O -– PUNCT B-O -End PROPN B-O -diastolic ADJ B-O -volume NOUN B-O -index NOUN B-O -, PUNCT B-O -ESVI PROPN B-O -– PUNCT B-O -End PROPN B-O -systolic ADJ B-O -volume NOUN B-O -index NOUN B-O -, PUNCT B-O -LV PROPN B-AC -– PUNCT B-O -left ADJ B-LF -ventricle NOUN I-LF -, PUNCT B-O -RV NOUN B-O -– PUNCT B-O -right ADJ B-O -ventricle NOUN B-O -, PUNCT B-O -SVI NOUN B-O -– PUNCT B-O -stroke NOUN B-O -volume NOUN B-O -. PUNCT B-O - -The DET B-O -surface NOUN B-O -- PUNCT B-O -exposed VERB B-O -P2 NOUN B-O -subdomain NOUN B-O -( PUNCT B-O -residues NOUN B-O -279–405 NUM B-O -) PUNCT B-O -[ X B-O -17 X B-O -] PUNCT B-O -interacts VERB B-O -with ADP B-O -histoblood NOUN B-LF -group NOUN I-LF -antigens NOUN I-LF -( PUNCT B-O -HBGAs PROPN B-AC -) PUNCT B-O -expressed VERB B-O -on ADP B-O -gut ADJ B-O -epithelial ADJ B-O -cells NOUN B-O -, PUNCT B-O -facilitating VERB B-O -virus NOUN B-O -binding NOUN B-O -and CCONJ B-O -entry NOUN B-O -resulting VERB B-O -in ADP B-O -infection NOUN B-O -[ X B-O -18 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Within ADP B-O -the DET B-O -ALs PROPN B-AC -, PUNCT B-O -the DET B-O -olfactory ADJ B-O -information NOUN B-O -is AUX B-O -processed VERB B-O -by ADP B-O -a DET B-O -complex ADJ B-O -network NOUN B-O -of ADP B-O -neurons NOUN B-O -, PUNCT B-O -including VERB B-O -OSNs PROPN B-AC -, PUNCT B-O -local ADJ B-LF -interneurons NOUN I-LF -( PUNCT B-O -LNs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -projection NOUN B-LF -neurons NOUN I-LF -( PUNCT B-O -PNs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -centrifugal ADJ B-LF -neurons NOUN I-LF -( PUNCT B-O -CNs PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Genetic ADJ B-O -- PUNCT B-O -variation NOUN B-O -studies NOUN B-O -have AUX B-O -primarily ADV B-O -been AUX B-O -focused VERB B-O -on ADP B-O -tumor NOUN B-O -somatic ADJ B-O -mutations NOUN B-O -or CCONJ B-O -on ADP B-O -germline ADJ B-O -single ADJ B-LF -- PUNCT I-LF -nucleotide NOUN I-LF -polymorphisms NOUN I-LF -( PUNCT B-O -SNPs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -AID PROPN B-AC -, PUNCT B-O -auxin NOUN B-LF -- PUNCT I-LF -inducible ADJ I-LF -degron NOUN I-LF -; PUNCT B-O -CENP PROPN B-AC -, PUNCT B-O -centromere NOUN B-LF -protein NOUN I-LF -A NOUN I-LF -; PUNCT B-O --AFL PROPN B-AC -, PUNCT B-O -full ADJ B-LF -- PUNCT I-LF -length NOUN I-LF -; PUNCT B-O -IF PROPN B-AC -, PUNCT B-O -immunofluorescence NOUN B-LF -; PUNCT B-O -RNAi PROPN B-AC -, PUNCT B-O -RNA NOUN B-LF -interference NOUN I-LF -; PUNCT B-O -WT PROPN B-O -, PUNCT B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -. PUNCT B-O - -In ADP B-O -order NOUN B-O -to PART B-O -delineate VERB B-O -the DET B-O -complex ADJ B-O -relationship NOUN B-O -among ADP B-O -chain NOUN B-O -connectivity NOUN B-O -, PUNCT B-O -protein NOUN B-O -folding NOUN B-O -, PUNCT B-O -coupled VERB B-O -networks NOUN B-O -, PUNCT B-O -and CCONJ B-O -catalysis NOUN B-O -by ADP B-O -DHFR PROPN B-AC -, PUNCT B-O -we PRON B-O -have AUX B-O -carried VERB B-O -out ADP B-O -a DET B-O -systematic ADJ B-O -network NOUN B-O -analysis NOUN B-O -and CCONJ B-O -molecular ADJ B-LF -dynamics NOUN I-LF -( PUNCT B-O -MD PROPN B-AC -) PUNCT B-O -simulations NOUN B-O -of ADP B-O -the DET B-O -native ADJ B-O -( PUNCT B-O -closed ADJ B-O -state NOUN B-O -) PUNCT B-O -DHFR PROPN B-AC -and CCONJ B-O -19 NUM B-O -of ADP B-O -its PRON B-O -circularly ADV B-O -permuted ADJ B-O -variants NOUN B-O -. PUNCT B-O - -Cervical ADJ B-O -cancer NOUN B-O -is AUX B-O -mainly ADV B-O -caused VERB B-O -by ADP B-O -sexually ADV B-O -transmitted VERB B-O -Human PROPN B-LF -Papilloma PROPN I-LF -Virus PROPN I-LF -( PUNCT B-O -HPV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -the DET B-O -most ADV B-O -common ADJ B-O -viral ADJ B-O -infection NOUN B-O -of ADP B-O -the DET B-O -female ADJ B-O -reproductive ADJ B-O -tract NOUN B-O -. PUNCT B-O - -Combining VERB B-O -sensitivity NOUN B-O -and CCONJ B-O -specificity NOUN B-O -, PUNCT B-O -we PRON B-O -calculated VERB B-O -likelihood NOUN B-LF -ratios NOUN I-LF -( PUNCT B-O -LR PROPN B-AC -) PUNCT B-O -for ADP B-O -different ADJ B-O -cut VERB B-O -- PUNCT B-O -off ADP B-O -points NOUN B-O -. PUNCT B-O - -MDA PROPN B-AC -levels NOUN B-O -in ADP B-O -cell NOUN B-O -lysates NOUN B-O -were AUX B-O -determined VERB B-O -by ADP B-O -high ADJ B-LF -- PUNCT I-LF -performance NOUN I-LF -liquid NOUN I-LF -chromatography NOUN I-LF -( PUNCT B-O -HPLC PROPN B-AC -) PUNCT B-O -as SCONJ B-O -shown VERB B-O -previously ADV B-O -[ X B-O -31 NUM B-O -] PUNCT B-O -. PUNCT B-O - -At ADP B-O -the DET B-O -end NOUN B-O -of ADP B-O -the DET B-O -study NOUN B-O -, PUNCT B-O -CO NOUN B-O -concentration NOUN B-O -in ADP B-O -the DET B-O -exhaled VERB B-O -gas NOUN B-O -of ADP B-O -each DET B-O -participant NOUN B-O -was AUX B-O -measured VERB B-O -, PUNCT B-O -and CCONJ B-O -indoor ADJ B-O -air NOUN B-O -pollutants NOUN B-O -( PUNCT B-O -i.e. X B-O -, PUNCT B-O -SO2 NOUN B-O -, PUNCT B-O -CO NOUN B-O -, PUNCT B-O -CO2 NOUN B-O -, PUNCT B-O -NO2 NOUN B-O -, PUNCT B-O -and CCONJ B-O -particulate NOUN B-LF -matter NOUN I-LF -with ADP I-LF -an DET I-LF -aerodynamic ADJ I-LF -diameter NOUN I-LF -of ADP I-LF -10 NUM I-LF -µm NOUN I-LF -or CCONJ I-LF -less ADJ I-LF -[ PUNCT B-O -PM10 PROPN B-AC -] PUNCT B-O -) PUNCT B-O -were AUX B-O -measured VERB B-O -for ADP B-O -one NUM B-O -- PUNCT B-O -third NOUN B-O -of ADP B-O -the DET B-O -participants NOUN B-O -' PART B-O -homes NOUN B-O -, PUNCT B-O -which PRON B-O -were AUX B-O -randomly ADV B-O -selected VERB B-O -through ADP B-O -a DET B-O -systematic ADJ B-O -random ADJ B-O -process NOUN B-O -as SCONJ B-O -previously ADV B-O -described VERB B-O -for ADP B-O -the DET B-O -baseline NOUN B-O -survey NOUN B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Here ADV B-O -, PUNCT B-O -we PRON B-O -used VERB B-O -RNA NOUN B-LF -interference NOUN I-LF -( PUNCT B-O -RNAi PROPN B-AC -) PUNCT B-O -to PART B-O -systematically ADV B-O -investigate VERB B-O -the DET B-O -roles NOUN B-O -of ADP B-O -Acps PROPN B-AC -in ADP B-O -inducing VERB B-O -changes NOUN B-O -in ADP B-O -egg NOUN B-O -laying NOUN B-O -, PUNCT B-O -fertility NOUN B-O -, PUNCT B-O -receptivity NOUN B-O -, PUNCT B-O -and CCONJ B-O -sperm NOUN B-O -storage NOUN B-O -. PUNCT B-O - -Over ADP B-O -recent ADJ B-O -years NOUN B-O -, PUNCT B-O -the DET B-O -use NOUN B-O -of ADP B-O -novel ADJ B-O -agents NOUN B-O -( PUNCT B-O -immunomodulatory ADJ B-O -drugs NOUN B-O -[ X B-O -lenalidomide NOUN B-O -, PUNCT B-O -thalidomide NOUN B-O -and CCONJ B-O -pomalidomide NOUN B-O -] PUNCT B-O -and CCONJ B-O -the DET B-O -proteasome NOUN B-O -inhibitor NOUN B-O -[ X B-O -bortezomib NOUN B-O -] PUNCT B-O -) PUNCT B-O -and CCONJ B-O -autologous ADJ B-LF -stem NOUN I-LF -cell NOUN I-LF -transplant NOUN I-LF -( PUNCT B-O -ASCT PROPN B-AC -) PUNCT B-O -in ADP B-O -patients NOUN B-O -eligible ADJ B-O -for ADP B-O -transplant NOUN B-O -has AUX B-O -improved VERB B-O -the DET B-O -outcomes NOUN B-O -of ADP B-O -patients NOUN B-O -with ADP B-O -MM PROPN B-AC -around ADP B-O -the DET B-O -world NOUN B-O -[ X B-O -2–6 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Apnea NOUN B-LF -- NOUN I-LF -Hypopnea NOUN I-LF -index NOUN I-LF -( PUNCT B-O -AHI PROPN B-AC -) PUNCT B-O -or CCONJ B-O -oxygen NOUN B-LF -de NOUN I-LF -- NOUN I-LF -saturation NOUN I-LF -index NOUN I-LF -( PUNCT B-O -ODI PROPN B-AC -) PUNCT B-O -were AUX B-O -also ADV B-O -independent ADJ B-O -factors NOUN B-O -of ADP B-O -DNA NOUN B-O -methylation NOUN B-O -levels NOUN B-O -of ADP B-O -the DET B-O -TLR2 NOUN B-O -promoter NOUN B-O -region NOUN B-O -, PUNCT B-O -TLR6 NOUN B-O -gene NOUN B-O -body NOUN B-O -, PUNCT B-O -and CCONJ B-O -protein NOUN B-O -expressions NOUN B-O -of ADP B-O -TLR6 NOUN B-O -( PUNCT B-O -S4 PROPN B-O -and CCONJ B-O -S5 PROPN B-O -Tables NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Subgroup NOUN B-O -comparisons NOUN B-O -of ADP B-O -the DET B-O -weighted VERB B-O -mean ADJ B-O -difference NOUN B-O -of ADP B-O -diastolic ADJ B-O -blood NOUN B-O -pressure NOUN B-O -between ADP B-O -South PROPN B-LF -Asians PROPN I-LF -( PUNCT B-O -SA PROPN B-AC -) PUNCT B-O -and CCONJ B-O -European ADJ B-O -participants NOUN B-O -( PUNCT B-O -EU PROPN B-AC -) PUNCT B-O -by ADP B-O -country NOUN B-O -of ADP B-O -origin NOUN B-O -. PUNCT B-O - -Quantitative ADJ B-O -measurement NOUN B-O -of ADP B-O -lipid NOUN B-O -peroxidation NOUN B-O -was AUX B-O -performed VERB B-O -in ADP B-O -cell NOUN B-O -homogenates NOUN B-O -according VERB B-O -to ADP B-O -the DET B-O -methods NOUN B-O -of ADP B-O -Tappel PROPN B-O -and CCONJ B-O -Zalkin PROPN B-O -, PUNCT B-O -1959 NUM B-O -[ PUNCT B-O -33 NUM B-O -] PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -based VERB B-O -on ADP B-O -the DET B-O -formation NOUN B-O -of ADP B-O -thiobarbituric NOUN B-LF -acid NOUN I-LF -reactive ADJ I-LF -substances NOUN I-LF -( PUNCT B-O -TBARS PROPN B-AC -) PUNCT B-O -and CCONJ B-O -expressed VERB B-O -as ADP B-O -the DET B-O -extent NOUN B-O -of ADP B-O -malondialdehyde NOUN B-LF -( PUNCT B-O -MDA PROPN B-AC -) PUNCT B-O -production NOUN B-O -. PUNCT B-O - -All DET B-O -villages NOUN B-O -were AUX B-O -Primary PROPN B-LF -Health PROPN I-LF -Care PROPN I-LF -Programme PROPN I-LF -( PUNCT B-O -PHC PROPN B-AC -) PUNCT B-O -villages NOUN B-O -and CCONJ B-O -had AUX B-O -a DET B-O -male ADJ B-O -village NOUN B-LF -health NOUN I-LF -worker NOUN I-LF -( PUNCT B-O -VHW PROPN B-AC -) PUNCT B-O -and CCONJ B-O -a DET B-O -traditional ADJ B-LF -birth NOUN I-LF -attendant NOUN I-LF -( PUNCT B-O -TBA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -both PRON B-O -of ADP B-O -whom PRON B-O -had AUX B-O -completed VERB B-O -a DET B-O -4 NUM B-O -- PUNCT B-O -week NOUN B-O -Gambian ADJ B-O -Ministry PROPN B-O -of ADP B-O -Health PROPN B-O -( PUNCT B-O -MoH PROPN B-O -) PUNCT B-O -training NOUN B-O -programme NOUN B-O -. PUNCT B-O - -E10.5 PROPN B-AC -, PUNCT B-O -embryonic ADJ B-LF -day NOUN I-LF -10.5 NUM I-LF -; PUNCT B-O -E11.5 PROPN B-AC -, PUNCT B-O -embryonic ADJ B-LF -day NOUN I-LF -11.5 NUM I-LF -; PUNCT B-O -EP PROPN B-O -, PUNCT B-O -embryo NOUN B-O -proper ADJ B-O -; PUNCT B-O -HM PROPN B-O -Ripk1D325A PROPN B-O -/ SYM B-O -D325A NOUN B-O -homozygotes NOUN B-O -; PUNCT B-O -NF PROPN B-AC -, PUNCT B-O -nuclear ADJ B-LF -factor NOUN I-LF -- PUNCT I-LF -kappa NOUN I-LF -B NOUN I-LF -; PUNCT B-O --κBWT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -- PUNCT I-LF -type NOUN I-LF -; PUNCT B-O -YS NOUN B-O -, PUNCT B-O -yolk NOUN B-O -sac NOUN B-O -. PUNCT B-O - -These DET B-O -PRRs PROPN B-AC -include VERB B-O -Toll NOUN B-LF -- PUNCT I-LF -like ADJ I-LF -receptors NOUN I-LF -( PUNCT B-O -TLRs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -receptor NOUN B-LF -for ADP I-LF -advanced ADJ I-LF -glycation NOUN I-LF -end NOUN I-LF -products NOUN I-LF -( PUNCT B-O -RAGE PROPN B-AC -) PUNCT B-O -and CCONJ B-O -scavenger NOUN B-O -receptors NOUN B-O -[ PUNCT B-O -59–61 NUM B-O -] PUNCT B-O -. PUNCT B-O - -B. PROPN B-O -malayi NOUN B-O -microfilaria NOUN B-O -worms NOUN B-O -were AUX B-O -purchased VERB B-O -from ADP B-O -TRS PROPN B-O -Labs PROPN B-O -( PUNCT B-O -Athens PROPN B-O -, PUNCT B-O -GA PROPN B-O -, PUNCT B-O -United PROPN B-O -States PROPN B-O -) PUNCT B-O -for ADP B-O -preparation NOUN B-O -of ADP B-O -DNA NOUN B-O -. PUNCT B-O - -Because SCONJ B-O -of ADP B-O -the DET B-O -difficulties NOUN B-O -in ADP B-O -obtaining VERB B-O -purified ADJ B-O -Wolbachia PROPN B-O -DNA NOUN B-O -from ADP B-O -the DET B-O -B. PROPN B-O -malayi NOUN B-O -host NOUN B-O -, PUNCT B-O -bacterial ADJ B-LF -artificial ADJ I-LF -chromosome NOUN I-LF -( PUNCT B-O -BAC PROPN B-AC -) PUNCT B-O -libraries NOUN B-O -were AUX B-O -created VERB B-O -[ PUNCT B-O -114 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -treatment NOUN B-O -regimen NOUN B-O -developed VERB B-O -from ADP B-O -this DET B-O -dose NOUN B-O -- ADJ B-O -finding VERB B-O -study NOUN B-O -has AUX B-O -now ADV B-O -been AUX B-O -carried VERB B-O -forward ADV B-O -into ADP B-O -the DET B-O -DIABIL-2 PROPN B-O -clinical ADJ B-O -trial NOUN B-O -to PART B-O -assess VERB B-O -the DET B-O -efficacy NOUN B-O -and CCONJ B-O -safety NOUN B-O -of ADP B-O -ultra ADJ B-O -- ADJ B-O -low ADJ B-O -doses NOUN B-O -of ADP B-O -recombinant ADJ B-LF -human ADJ I-LF -IL-2 NOUN I-LF -( PUNCT B-O -rhIL-2 PROPN B-AC -) PUNCT B-O -in ADP B-O -children NOUN B-O -and CCONJ B-O -adults NOUN B-O -with ADP B-O -T1D PROPN B-AC -[ PUNCT B-O -37 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -516 NUM B-O -conceptus NOUN B-O -cells NOUN B-O -consist VERB B-O -of ADP B-O -cells NOUN B-O -of ADP B-O -EPI PROPN B-AC -, PUNCT B-O -primitive ADJ B-LF -endoderm NOUN I-LF -( PUNCT B-O -PE PROPN B-AC -) PUNCT B-O -and CCONJ B-O -TE PROPN B-AC -lineages NOUN B-O -. PUNCT B-O - -In ADP B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -animals NOUN B-O -, PUNCT B-O -mutation NOUN B-O -or CCONJ B-O -RNA NOUN B-LF -interference NOUN I-LF -( PUNCT B-O -RNAi PROPN B-AC -) PUNCT B-O -of ADP B-O -individual ADJ B-O -Wnt PROPN B-O -genes NOUN B-O -did AUX B-O -not PART B-O -reduce VERB B-O -the DET B-O -normal ADJ B-O -frequency NOUN B-O -of ADP B-O -vulval ADJ B-O -fates NOUN B-O -( PUNCT B-O -Table PROPN B-O -2 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Beyond ADP B-O -JIA PROPN B-AC -, PUNCT B-O -our PRON B-O -approach NOUN B-O -may AUX B-O -be AUX B-O -a DET B-O -transferrable ADJ B-O -template NOUN B-O -for ADP B-O -application NOUN B-O -in ADP B-O -rheumatoid ADJ B-LF -arthritis NOUN I-LF -( PUNCT B-O -RA PROPN B-AC -) PUNCT B-O -and CCONJ B-O -spondyloarthropathies NOUN B-O -( PUNCT B-O -SpAs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Error NOUN B-O -bars NOUN B-O -indicated VERB B-O -SEM PROPN B-O -. PUNCT B-O - -AAV PROPN B-AC -, PUNCT B-O -adeno NOUN B-LF -- PUNCT I-LF -associated VERB I-LF -virus NOUN I-LF -; PUNCT B-O -ANOVA PROPN B-AC -, PUNCT B-O -Analysis PROPN B-LF -of ADP I-LF -Variance NOUN I-LF -; PUNCT B-O -DHPG PROPN B-AC -, PUNCT B-O -( PUNCT B-O -S)-3,5 NOUN B-O -- PUNCT B-O -Dihydroxyphenylglycine NOUN B-O -; PUNCT B-O -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -GlyR PROPN B-AC -, PUNCT B-O -glycine NOUN B-LF -receptor NOUN I-LF -; PUNCT B-O -IPSC PROPN B-AC -, PUNCT B-O -inhibitory ADJ B-LF -postsynaptic ADJ I-LF -current NOUN I-LF -; PUNCT B-O -mIPSC PROPN B-AC -, PUNCT B-O -miniature ADJ B-LF -IPSC NOUN I-LF -IPSC PROPN B-AC -; PUNCT B-O -NC PROPN B-AC -, PUNCT B-O -negative ADJ B-LF -control NOUN I-LF -shRNA NOUN I-LF -shRNA PROPN B-AC -; PUNCT B-O -RPM PROPN B-AC -, PUNCT B-O -rounds NOUN B-LF -per ADP I-LF -minute NOUN I-LF -; PUNCT B-O -shRNA PROPN B-AC -, PUNCT B-O -short ADJ B-LF -hairpin NOUN I-LF -RNA NOUN I-LF -. PUNCT B-O - -The DET B-O -WHO PROPN B-O -group NOUN B-O -wanted VERB B-O -to ADP B-O -know VERB B-O -how SCONJ B-O -these DET B-O -treatments NOUN B-O -affected VERB B-O -the DET B-O -virus NOUN B-O -outside ADP B-O -the DET B-O -body NOUN B-O -( PUNCT B-O -“ PUNCT B-O -in ADP B-O -vitro X B-O -” PUNCT B-O -) PUNCT B-O -and CCONJ B-O -whether SCONJ B-O -it PRON B-O -helped VERB B-O -the DET B-O -condition NOUN B-O -of ADP B-O -patients NOUN B-O -and CCONJ B-O -reduced VERB B-O -the DET B-O -death NOUN B-O -rate NOUN B-O -, PUNCT B-O -particularly ADV B-O -in ADP B-O -those DET B-O -patients NOUN B-O -who PRON B-O -developed VERB B-O -the DET B-O -dangerous ADJ B-O -complication NOUN B-O -called VERB B-O -acute ADJ B-LF -respiratory ADJ I-LF -distress NOUN I-LF -syndrome NOUN I-LF -( PUNCT B-O -ARDS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -This DET B-O -study NOUN B-O -is AUX B-O -a DET B-O -systematic ADJ B-O -review NOUN B-O -conducted VERB B-O -in ADP B-O -response NOUN B-O -to ADP B-O -the DET B-O -WHO PROPN B-O -request NOUN B-O -. PUNCT B-O - -( PUNCT B-O -A X B-O -) PUNCT B-O -Hippo PROPN B-O -signaling NOUN B-O -pathway NOUN B-O -, PUNCT B-O -( PUNCT B-O -B X B-O -) PUNCT B-O -Focal ADJ B-O -adhesion NOUN B-O -and CCONJ B-O -( PUNCT B-O -C X B-O -) PUNCT B-O -Cell NOUN B-LF -adhesion NOUN I-LF -molecules NOUN I-LF -( PUNCT B-O -CAMs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Fluorescence NOUN B-LF -recovery NOUN I-LF -after ADP I-LF -photobleaching NOUN I-LF -( PUNCT B-O -FRAP PROPN B-AC -) PUNCT B-O -was AUX B-O -performed VERB B-O -to PART B-O -compare VERB B-O -the DET B-O -mobility NOUN B-O -and CCONJ B-O -dynamics NOUN B-O -of ADP B-O -the DET B-O -mutant ADJ B-O -variants NOUN B-O -with ADP B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -myotilin NOUN B-O -( PUNCT B-O -Fig NOUN B-O -5A NUM B-O -) PUNCT B-O -. PUNCT B-O - -Wild ADJ B-O -- PUNCT B-O -type NOUN B-O -myotilin NOUN B-O -showed VERB B-O -rapid ADJ B-O -dynamics NOUN B-O -with ADP B-O -80 NUM B-O -% NOUN B-O -fluorescence NOUN B-O -recovery NOUN B-O -after ADP B-O -300 NUM B-O -s NOUN B-O -( PUNCT B-O -median ADJ B-O -half ADJ B-O -- PUNCT B-O -time NOUN B-O -t1/2 NUM B-O -of ADP B-O -72.4 NUM B-O -s NOUN B-O -) PUNCT B-O -( PUNCT B-O -Fig NOUN B-O -5B NUM B-O -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -in ADP B-O -excellent ADJ B-O -agreement NOUN B-O -with ADP B-O -previously ADV B-O -published VERB B-O -reports NOUN B-O -[ PUNCT B-O -50,51 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -ability NOUN B-O -of ADP B-O -α PUNCT B-LF -- PUNCT I-LF -methyl NOUN I-LF -- PUNCT I-LF -p NOUN I-LF -- PUNCT I-LF -tyrosine NOUN I-LF -( PUNCT B-O -αMT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -potent ADJ B-O -irreversible ADJ B-O -inhibitor NOUN B-O -of ADP B-O -TH PROPN B-AC -[ PUNCT B-O -29,45,46 NUM B-O -] PUNCT B-O -, PUNCT B-O -to PART B-O -impede VERB B-O -production NOUN B-O -of ADP B-O -brain NOUN B-O -DA PROPN B-AC -suggests VERB B-O -a DET B-O -simple ADJ B-O -, PUNCT B-O -but CCONJ B-O -straightforward ADJ B-O -, PUNCT B-O -strategy NOUN B-O -for ADP B-O -producing VERB B-O -an DET B-O -acute ADJ B-O -PD PROPN B-AC -mouse NOUN B-O -model NOUN B-O -. PUNCT B-O - -In ADP B-O -this DET B-O -context NOUN B-O -, PUNCT B-O -adult NOUN B-O -bone NOUN B-O -marrow NOUN B-O -derived VERB B-O -mesenchymal ADJ B-LF -stem NOUN I-LF -cells NOUN I-LF -( PUNCT B-O -BM-MSCs PROPN B-AC -) PUNCT B-O -represent VERB B-O -the DET B-O -most ADV B-O -studied ADJ B-O -cell NOUN B-O -type NOUN B-O -for ADP B-O -cardiac ADJ B-O -repair NOUN B-O -due ADP B-O -to ADP B-O -their PRON B-O -unique ADJ B-O -features NOUN B-O -including VERB B-O -the DET B-O -ease NOUN B-O -in ADP B-O -their PRON B-O -isolation NOUN B-O -/ SYM B-O -expansion NOUN B-O -, PUNCT B-O -their PRON B-O -paracrine NOUN B-O -activity NOUN B-O -to ADP B-O -induce VERB B-O -neovascularization ADJ B-O -post ADJ B-O -ischemic ADJ B-O -injury NOUN B-O -and CCONJ B-O -most ADV B-O -importantly ADV B-O -due ADP B-O -to ADP B-O -their PRON B-O -immunomodulatory ADJ B-O -properties NOUN B-O -[ X B-O -1–5 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Arrow NOUN B-O -indicates VERB B-O -BRCA2 PROPN B-O -deficiency NOUN B-O -threshold NOUN B-O -. PUNCT B-O - -( PUNCT B-O -C X B-O -) PUNCT B-O -Number NOUN B-O -of ADP B-O -silent ADJ B-O -or CCONJ B-O -non ADJ B-O -- PUNCT B-O -silent ADJ B-O -mutations NOUN B-O -, PUNCT B-O -mutation NOUN B-O -signatures NOUN B-O -, PUNCT B-O -and CCONJ B-O -BRCA PROPN B-O -deficiency NOUN B-O -in ADP B-O -TCGA PROPN B-AC -TNBCs PROPN B-AC -. PUNCT B-O - -BRCA-D PROPN B-AC -, PUNCT B-O -BRCA PROPN B-LF -- PUNCT I-LF -deficient ADJ I-LF -; PUNCT B-O -BRCA PROPN B-AC -, PUNCT B-O -BRCA PROPN B-LF -- PUNCT I-LF -normal ADJ I-LF -; PUNCT B-O -CNV PROPN B-O -, PUNCT B-O -copy NOUN B-O -number NOUN B-O -variation NOUN B-O -; PUNCT B-O -MMR PROPN B-O -, PUNCT B-O -mismatch NOUN B-O -repair NOUN B-O -; PUNCT B-O -Mut PROPN B-O -, PUNCT B-O -mutation NOUN B-O -; PUNCT B-O -SNV PROPN B-O -, PUNCT B-O -single ADJ B-O -nucleotide NOUN B-O -variant NOUN B-O -; PUNCT B-O --NTCGA PROPN B-AC -, PUNCT B-O -The PRON B-LF -Cancer PROPN I-LF -Genome PROPN I-LF -Atlas PROPN I-LF -; PUNCT B-O -TNBC PROPN B-AC -, PUNCT B-O -triple ADV B-LF -negative ADJ I-LF -breast NOUN I-LF -cancer NOUN I-LF -; PUNCT B-O -WT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -- PUNCT I-LF -type NOUN I-LF -. PUNCT B-O - -The DET B-O -Circumplex PROPN B-LF -of ADP I-LF -Interpersonal PROPN I-LF -Problems PROPN I-LF -( PUNCT B-O -CIP PROPN B-AC -) PUNCT B-O -[ X B-O -64 X B-O -] X B-O -was AUX B-O -used VERB B-O -to PART B-O -assess VERB B-O -interpersonal ADJ B-O -personal ADJ B-O -problems NOUN B-O -. PUNCT B-O - -Data NOUN B-O -can AUX B-O -be AUX B-O -made VERB B-O -available ADJ B-O -by ADP B-O -the DET B-O -Health PROPN B-LF -Informatics PROPN I-LF -Centre PROPN I-LF -, PUNCT B-O -University PROPN B-O -of ADP B-O -Dundee PROPN B-O -( PUNCT B-O -contact VERB B-O -via ADP B-O -hicsupport@dundee.ac.uk X B-O -) PUNCT B-O -with ADP B-O -the DET B-O -HIC PROPN B-AC -Safe PROPN B-O -Haven PROPN B-O -for ADP B-O -researchers NOUN B-O -who PRON B-O -meet VERB B-O -the DET B-O -criteria NOUN B-O -for ADP B-O -access NOUN B-O -to ADP B-O -confidential ADJ B-O -data NOUN B-O -and CCONJ B-O -subject ADJ B-O -to ADP B-O -a DET B-O -data NOUN B-O -access NOUN B-O -fee NOUN B-O -. PUNCT B-O - -Indeed ADV B-O -, PUNCT B-O -we PRON B-O -found VERB B-O -that SCONJ B-O -sperm NOUN B-O -enter VERB B-O -preferentially ADV B-O -into ADP B-O -the DET B-O -polar ADJ B-LF -body NOUN I-LF -( PUNCT B-O -pb PROPN B-AC -) PUNCT B-O -half NOUN B-O -, PUNCT B-O -except SCONJ B-O -for ADP B-O -the DET B-O -microvilli NOUN B-O -- ADJ B-O -free ADJ B-O -area NOUN B-O -directly ADV B-O -above ADP B-O -the DET B-O -metaphase NOUN B-O -chromosomes NOUN B-O -[ PUNCT B-O -11 NUM B-O -] PUNCT B-O -, PUNCT B-O -whereas SCONJ B-O -an DET B-O -earlier ADJ B-O -study NOUN B-O -reported VERB B-O -that SCONJ B-O -more ADJ B-O -sperm NOUN B-O -enter VERB B-O -in ADP B-O -the DET B-O -“ PUNCT B-O -vegetal ADJ B-O -” PUNCT B-O -area NOUN B-O -[ PUNCT B-O -10 NUM B-O -] PUNCT B-O -. PUNCT B-O - -WGV PROPN B-AC -; PUNCT B-O -weight NOUN B-LF -growth NOUN I-LF -velocity NOUN I-LF -, PUNCT B-O -SD PROPN B-AC -; PUNCT B-O -standard ADJ B-LF -deviation NOUN I-LF -, PUNCT B-O -PROM PROPN B-AC -; PUNCT B-O -preterm ADJ B-LF -rupture NOUN I-LF -of ADP I-LF -membrane NOUN I-LF -, PUNCT B-O -SGA PROPN B-AC -; PUNCT B-O -small ADJ B-LF -for ADP I-LF -gestational ADJ I-LF -age NOUN I-LF -, PUNCT B-O -AS PROPN B-AC -; PUNCT B-O -Apgar PROPN B-LF -score NOUN I-LF -, PUNCT B-O -RDS PROPN B-AC -; PUNCT B-O -respiratory ADJ B-LF -distress NOUN I-LF -syndrome NOUN I-LF -, PUNCT B-O -CLD PROPN B-AC -; PUNCT B-O -chronic ADJ B-LF -lung NOUN I-LF -disease NOUN I-LF -, PUNCT B-O -PDA PROPN B-AC -; PUNCT B-O -patent NOUN B-LF -ductus NOUN I-LF -arteriosus NOUN I-LF -, PUNCT B-O -NEC PROPN B-AC -; PUNCT B-O -necrotizing VERB B-LF -enterocolitis NOUN I-LF -, PUNCT B-O -IVH PROPN B-AC -; PUNCT B-O -intraventricular ADJ B-LF -hemorrhage NOUN I-LF -. PUNCT B-O - -Other ADJ B-O -information NOUN B-O -available ADJ B-O -in ADP B-O -MMBNT PROPN B-AC -’s PART B-O -dataset NOUN B-O -includes VERB B-O -: PUNCT B-O -Donor PROPN B-O -ID PROPN B-O -, PUNCT B-O -Baby PROPN B-O -Date NOUN B-LF -of ADP I-LF -Birth PROPN I-LF -( PUNCT B-O -DOB PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Baby PROPN B-O -Term PROPN B-O -( PUNCT B-O -full ADJ B-O -term NOUN B-O -, PUNCT B-O -preterm ADJ B-O -, PUNCT B-O -or CCONJ B-O -deceased ADJ B-O -) PUNCT B-O -, PUNCT B-O -Deposit NOUN B-O -Receipt PROPN B-O -Date NOUN B-O -, PUNCT B-O -Deposit NOUN B-O -Expiration NOUN B-O -Date NOUN B-O -, PUNCT B-O -and CCONJ B-O -Deposit NOUN B-O -Volume NOUN B-O -. PUNCT B-O - -The DET B-O -care NOUN B-O -provided VERB B-O -by ADP B-O -skilled ADJ B-O -health NOUN B-O -care NOUN B-O -professionals NOUN B-O -to PART B-O -pregnant ADJ B-O -women NOUN B-O -and CCONJ B-O -adolescent ADJ B-O -girls NOUN B-O -in ADP B-O -order NOUN B-O -to PART B-O -ensure VERB B-O -the DET B-O -best ADJ B-O -health NOUN B-O -conditions NOUN B-O -for ADP B-O -both CCONJ B-O -mother NOUN B-O -and CCONJ B-O -baby NOUN B-O -during ADP B-O -pregnancy NOUN B-O -is AUX B-O -considered VERB B-O -Antenatal ADJ B-LF -care NOUN I-LF -( PUNCT B-O -ANC PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Tau PROPN B-O -belongs VERB B-O -to ADP B-O -the DET B-O -class NOUN B-O -of ADP B-O -natively ADV B-O -unfolded VERB B-O -proteins NOUN B-O -, PUNCT B-O -binds VERB B-O -to ADP B-O -and CCONJ B-O -stabilizes VERB B-O -microtubules NOUN B-O -, PUNCT B-O -and CCONJ B-O -partially ADV B-O -folds VERB B-O -into ADP B-O -an DET B-O -ordered ADJ B-O -β PUNCT B-O -- NOUN B-O -structure NOUN B-O -during NOUN B-O -aggregation NOUN B-O -to ADP B-O -Alzheimer PROPN B-O -paired VERB B-LF -helical ADJ I-LF -filaments NOUN I-LF -( PUNCT B-O -PHFs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -insoluble ADJ B-O -pellet NOUN B-O -or CCONJ B-O -acid NOUN B-LF -insoluble ADJ I-LF -matrix NOUN I-LF -( PUNCT B-O -AIM PROPN B-AC -) PUNCT B-O -was AUX B-O -washed VERB B-O -with ADP B-O -MilliQ PROPN B-O -water NOUN B-O -several ADJ B-O -times NOUN B-O -. PUNCT B-O - -Our PRON B-O -ongoing ADJ B-O -investigations NOUN B-O -and CCONJ B-O -recently ADV B-O -published VERB B-O -reports NOUN B-O -indicated VERB B-O -that SCONJ B-O -IV NOUN B-O -formulation NOUN B-O -of ADP B-O -HET0016 PROPN B-O -with ADP B-O -2 NUM B-LF -- PUNCT I-LF -Hydroxypropyl NOUN I-LF -Beta PROPN I-LF -Cyclodextrin PROPN I-LF -( PUNCT B-O -HPßCD PROPN B-AC -) PUNCT B-O -( PUNCT B-O -HPßCD PROPN B-AC -- PUNCT B-O -HET0016 PROPN B-O -) PUNCT B-O -, PUNCT B-O -a DET B-O -20 PROPN B-AC -synthesis NOUN B-O -inhibitor NOUN B-O -, PUNCT B-O -not PART B-O -only ADV B-O -decreased VERB B-O -the DET B-O -tumor NOUN B-O -size NOUN B-O -but CCONJ B-O -also ADV B-O -inhibited VERB B-O -the DET B-O -invasiveness NOUN B-O -of ADP B-O -these DET B-O -cancer NOUN B-O -cells NOUN B-O -in ADP B-O -animal NOUN B-O -models NOUN B-O -of ADP B-O -human ADJ B-O -glioma NOUN B-O -[ PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -and CCONJ B-O -consistent ADJ B-O -with ADP B-O -the DET B-O -recruitment NOUN B-O -of ADP B-O -attention NOUN B-O -, PUNCT B-O -functional ADJ B-LF -MRI NOUN I-LF -( PUNCT B-O -fMRI PROPN B-AC -) PUNCT B-O -analyses NOUN B-O -of ADP B-O -late ADJ B-O -learning NOUN B-O -stages NOUN B-O -showed VERB B-O -left ADJ B-O -parietal ADJ B-O -activity NOUN B-O -within ADP B-O -a DET B-O -broad ADJ B-O -bilateral ADJ B-O -dorsal ADJ B-O -frontoparietal ADJ B-O -network NOUN B-O -. PUNCT B-O - -Body NOUN B-LF -surface NOUN I-LF -area NOUN I-LF -( PUNCT B-O -BSA PROPN B-AC -) PUNCT B-O -was AUX B-O -calculated VERB B-O -using VERB B-O -the DET B-O -formula NOUN B-O -: PUNCT B-O -0.0001 NUM B-O -x NOUN B-O -71.84 NUM B-O -x NOUN B-O -( PUNCT B-O -weight NOUN B-O -[ PUNCT B-O -kg])0.425 NUM B-O -x NOUN B-O -( PUNCT B-O -height NOUN B-O -[ PUNCT B-O -cm])0.725 NUM B-O -. PUNCT B-O - -The DET B-O -PMTCT PROPN B-LF -Effectiveness PROPN I-LF -PMTCT PROPN B-AC -in ADP I-LF -Africa PROPN I-LF -: PUNCT I-LF -Research PROPN I-LF -and CCONJ I-LF -Linkages PROPN I-LF -to ADP I-LF -Care PROPN I-LF -Study PROPN I-LF -( PUNCT B-O -PEARLStudy PROPN B-AC -) PUNCT B-O -was AUX B-O -a DET B-O -multi ADJ B-O -- ADJ B-O -country ADJ B-O -evaluation NOUN B-O -of ADP B-O -the DET B-O -effectiveness NOUN B-O -of ADP B-O -PMTCT PROPN B-AC -services NOUN B-O -at ADP B-O -the DET B-O -community NOUN B-O -and CCONJ B-O -facility NOUN B-O -level NOUN B-O -. PUNCT B-O - -R NOUN B-O -- PUNCT B-O -loops NOUN B-O -can AUX B-O -recruit VERB B-O -their PRON B-O -reader NOUN B-O -( PUNCT B-O -growth NOUN B-LF -arrest NOUN I-LF -and CCONJ I-LF -DNA NOUN I-LF -damage NOUN I-LF -protein NOUN I-LF -45A NOUN I-LF -[ PUNCT B-O -GADD45A PROPN B-AC -] PUNCT B-O -) PUNCT B-O -to PART B-O -promote VERB B-O -the DET B-O -demethylation NOUN B-O -pathway NOUN B-O -at ADP B-O -promoter NOUN B-O -cytosine NOUN B-LF -- PUNCT I-LF -phosphate NOUN I-LF -- PUNCT I-LF -guanine NOUN I-LF -( PUNCT B-O -CpG PROPN B-AC -) PUNCT B-O -islands NOUN B-O -in ADP B-O -human ADJ B-O -cells NOUN B-O -[ PUNCT B-O -44 NUM B-O -] PUNCT B-O -. PUNCT B-O - -We PRON B-O -utilized VERB B-O -multiple ADJ B-O -publicly ADV B-O -available ADJ B-O -data NOUN B-O -sources NOUN B-O -to PART B-O -evaluate VERB B-O -the DET B-O -association NOUN B-O -between ADP B-O -introduction NOUN B-O -of ADP B-O -PMI PROPN B-AC -and CCONJ B-O -child NOUN B-O -mortality NOUN B-O -rates NOUN B-O -in ADP B-O -sub ADJ B-LF -- ADJ I-LF -Saharan ADJ I-LF -Africa PROPN I-LF -( PUNCT B-O -SSA PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -To PART B-O -test VERB B-O -whether SCONJ B-O -hemoglobin NOUN B-O -levels NOUN B-O -were AUX B-O -significantly ADV B-O -different ADJ B-O -between ADP B-O -the DET B-O -groups NOUN B-O -we PRON B-O -used VERB B-O -a DET B-O -mixed VERB B-O -linear ADJ B-O -model NOUN B-O -that PRON B-O -adjusts VERB B-O -for ADP B-O -repeated VERB B-O -measures NOUN B-O -over ADP B-O -the DET B-O -period NOUN B-O -of ADP B-O -observation NOUN B-O -and CCONJ B-O -also ADV B-O -adjusts VERB B-O -for ADP B-O -coinfections NOUN B-O -with ADP B-O -schistosomiasis NOUN B-O -, PUNCT B-O -lymphatic ADJ B-O -filariasis NOUN B-O -and/or CCONJ B-O -hookworm NOUN B-O -, PUNCT B-O -as ADP B-O -well ADV B-O -as ADP B-O -height NOUN B-O -and CCONJ B-O -weight NOUN B-O -measurements NOUN B-O -( PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -[ PUNCT B-O -BMI PROPN B-AC -] PUNCT B-O -, PUNCT B-O -a DET B-O -surrogate NOUN B-O -for ADP B-O -nutritional ADJ B-O -status NOUN B-O -) PUNCT B-O -from ADP B-O -each DET B-O -follow NOUN B-O -- PUNCT B-O -up NOUN B-O -. PUNCT B-O - -CD59 NOUN B-O -is AUX B-O -a DET B-O -membrane NOUN B-O -complement NOUN B-O -regulatory ADJ B-O -protein NOUN B-O -that PRON B-O -is AUX B-O -attached VERB B-O -to ADP B-O -the DET B-O -cell NOUN B-O -membrane NOUN B-O -via ADP B-O -a DET B-O -glycosylphosphatidylinositol NOUN B-LF -( PUNCT B-O -GPI PROPN B-AC -) PUNCT B-O -anchor NOUN B-O -. PUNCT B-O - -Leptin NOUN B-O -receptors NOUN B-O -have AUX B-O -been AUX B-O -found VERB B-O -on ADP B-O -paraventricular ADJ B-LF -nucleus NOUN I-LF -( PUNCT B-O -PVN PROPN B-AC -) PUNCT B-O -and CCONJ B-O -lateral ADJ B-LF -hypothalamic ADJ I-LF -( PUNCT B-O -LHA PROPN B-AC -) PUNCT B-O -neurons NOUN B-O -, PUNCT B-O -implicating VERB B-O -them PRON B-O -as ADP B-O -direct ADJ B-O -targets NOUN B-O -for ADP B-O -regulation NOUN B-O -by ADP B-O -circulating VERB B-O -adiposity NOUN B-O -signals NOUN B-O -. PUNCT B-O - -Cadmium NOUN B-LF -( PUNCT B-O -Cd PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -developmental ADJ B-O -toxicant NOUN B-O -that PRON B-O -induces VERB B-O -fetal ADJ B-LF -growth NOUN I-LF -restriction NOUN I-LF -( PUNCT B-O -FGR PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Placental ADJ B-O -endoplasmic ADJ B-O -reticulum NOUN B-O -( PUNCT B-O -ER PROPN B-O -) PUNCT B-O -stress NOUN B-O -is AUX B-O -associated VERB B-O -with ADP B-O -FGR PROPN B-AC -. PUNCT B-O - -This DET B-O -study NOUN B-O -investigated VERB B-O -the DET B-O -effects NOUN B-O -of ADP B-O -N NOUN B-LF -- PUNCT I-LF -acetylcysteine NOUN I-LF -( PUNCT B-O -NAC PROPN B-AC -) PUNCT B-O -on ADP B-O -Cd PROPN B-AC -- PUNCT B-O -induced VERB B-O -placental ADJ B-O -ER PROPN B-AC -and CCONJ B-O -stressFGR PROPN B-AC -. PUNCT B-O - -Pregnant ADJ B-O -mice NOUN B-O -were AUX B-O -intraperitoneally ADV B-O -injected VERB B-O -with ADP B-O -CdCl2 PROPN B-O -daily ADV B-O -from ADP B-O -gestational ADJ B-LF -day NOUN I-LF -( PUNCT B-O -GD)13 PROPN B-AC -to ADP B-O -GD17 NUM B-O -. PUNCT B-O - -Reviewer#2 NOUN B-O -: PUNCT B-O -This DET B-O -manuscript NOUN B-O -describes VERB B-O -a DET B-O -novel ADJ B-O -matrix NOUN B-LF -- PUNCT I-LF -assisted VERB I-LF -laser NOUN I-LF -desorption NOUN I-LF -/ SYM I-LF -ionization NOUN I-LF -time NOUN I-LF -- PUNCT I-LF -of ADP I-LF -- PUNCT I-LF -flight NOUN I-LF -mass NOUN I-LF -spectrometry NOUN I-LF -( PUNCT B-O -MALDI-TOF-MS PROPN B-AC -) PUNCT B-O -analysis NOUN B-O -of ADP B-O -the DET B-O -extracted VERB B-O -peptides NOUN B-O -obtained VERB B-O -from ADP B-O -Streptococcus PROPN B-O -suis PROPN B-O -, PUNCT B-O -and CCONJ B-O -in ADP B-O -particularly ADV B-O -S. PROPN B-O -suis PROPN B-O -serotype NOUN B-O -( PUNCT B-O -SS2 NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Replicated VERB B-O -hybridisation NOUN B-O -to ADP B-O -genomic ADJ B-O -DNA NOUN B-O -tiling NOUN B-O -arrays NOUN B-O -generated VERB B-O -a DET B-O -dataset NOUN B-O -( PUNCT B-O -Dataset PROPN B-O -S1 PROPN B-O -) PUNCT B-O -with ADP B-O -mean ADJ B-LF -enrichments NOUN I-LF -( PUNCT B-O -Mn PROPN B-AC -) PUNCT B-O -equivalent ADJ B-O -to ADP B-O -log2 NUM B-O -3.8 NUM B-O -( PUNCT B-O -14 NUM B-O -- ADJ B-O -fold ADJ B-O -) PUNCT B-O -observed VERB B-O -. PUNCT B-O - -Therefore ADV B-O -, PUNCT B-O -our PRON B-O -estimates NOUN B-O -at ADP B-O -such ADJ B-O -high ADJ B-O -thresholds NOUN B-O -might AUX B-O -be AUX B-O -approximately ADV B-O -correct ADJ B-O -; PUNCT B-O -if SCONJ B-O -so ADV B-O -, PUNCT B-O -the DET B-O -accuracy NOUN B-O -of ADP B-O -homology NOUN B-O -transfer NOUN B-O -for ADP B-O -high ADJ B-O -similarity NOUN B-O -( PUNCT B-O -HVAL PROPN B-AC -> SYM B-O -40 NUM B-O -, PUNCT B-O -Percentage NOUN B-LF -sequence NOUN I-LF -IDEntity NOUN I-LF -( PUNCT B-O -PIDE PROPN B-AC -) PUNCT B-O -> SYM B-O -70 NUM B-O -) PUNCT B-O -were AUX B-O -just ADV B-O -over ADP B-O -10 NUM B-O -% NOUN B-O -( PUNCT B-O -Figure PROPN B-O -2 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -FGC PROPN B-AC -, PUNCT B-O -female ADJ B-LF -genital ADJ I-LF -cutting NOUN I-LF -; PUNCT B-O -MoH PROPN B-AC -, PUNCT B-O -Ministry PROPN B-LF -of ADP I-LF -Health PROPN I-LF -However ADV B-O -, PUNCT B-O -type NOUN B-O -D NOUN B-O -is AUX B-O -a DET B-O -limited ADJ B-O -and CCONJ B-O -specific ADJ B-O -aspect NOUN B-O -of ADP B-O -personality NOUN B-O -, PUNCT B-O -and CCONJ B-O -currently ADV B-O -the DET B-O -Five NUM B-LF -Factor PROPN I-LF -Model PROPN I-LF -( PUNCT B-O -FFM PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -more ADV B-O -accepted ADJ B-O -, PUNCT B-O -widely ADV B-O -used VERB B-O -and CCONJ B-O -comprehensive ADJ B-O -means NOUN B-O -of ADP B-O -categorization NOUN B-O -[ PUNCT B-O -21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -presence NOUN B-O -of ADP B-O -ITPase PROPN B-AC -deficiency NOUN B-O -was AUX B-O -not PART B-O -statistically ADV B-O -associated VERB B-O -with ADP B-O -a DET B-O -lower ADJ B-O -hazard NOUN B-LF -ratio NOUN I-LF -( PUNCT B-O -HR PROPN B-AC -) PUNCT B-O -for ADP B-O -RBV PROPN B-AC -dose NOUN B-O -reductions NOUN B-O -( PUNCT B-O -HR PROPN B-AC -0.80 NUM B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -0.35–1.71 NUM B-O -, PUNCT B-O -p NOUN B-O -= SYM B-O -0.57 NUM B-O -) PUNCT B-O -. PUNCT B-O - -BMP PROPN B-AC -, PUNCT B-O -Bone PROPN B-LF -Morphogenetic PROPN I-LF -Protein PROPN I-LF -; PUNCT B-O -FISH PROPN B-AC -, PUNCT B-O -fluorescent ADJ B-LF -in ADP I-LF -situ NOUN I-LF -hybridization NOUN I-LF -; PUNCT B-O -hpf PROPN B-AC -, PUNCT B-O -hours NOUN B-LF -post ADP I-LF -fertilization NOUN I-LF -; PUNCT B-O -pSmad5 PROPN B-AC -, PUNCT B-O -phosphorylated VERB B-LF -Smad5 NOUN I-LF -; PUNCT B-O -WT PROPN B-O -, PUNCT B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -. PUNCT B-O - -NF-κB PROPN B-AC -dimers NOUN B-O -are AUX B-O -sequestered VERB B-O -in ADP B-O -the DET B-O -cytoplasm NOUN B-O -by ADP B-O -an DET B-O -inhibitory ADJ B-O -protein NOUN B-O -IκBα PROPN B-O -, PUNCT B-O -which PRON B-O -masks VERB B-O -the DET B-O -conserved VERB B-O -nuclear ADJ B-LF -localization NOUN I-LF -sequence NOUN I-LF -( PUNCT B-O -NLS PROPN B-AC -) PUNCT B-O -of ADP B-O -RelA PROPN B-O -/ SYM B-O -p65 NOUN B-O -to PART B-O -prevent VERB B-O -nuclear ADJ B-O -translocation NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -AMPK PROPN B-AC -, PUNCT B-O -AMP NOUN B-O -- PUNCT B-O -activated VERB B-O -protein NOUN B-O -kinase NOUN B-O -; PUNCT B-O -AUC PROPN B-AC -, PUNCT B-O -area NOUN B-LF -under ADP I-LF -the DET I-LF -curve NOUN I-LF -; PUNCT B-O -Glut2 PROPN B-AC -, PUNCT B-O -glucose NOUN B-LF -transporter NOUN I-LF -2 NUM I-LF -; PUNCT B-O -GTT PROPN B-AC -, PUNCT B-O -glucose NOUN B-LF -tolerance NOUN I-LF -test NOUN I-LF -; PUNCT B-O -GS PROPN B-AC -, PUNCT B-O -glycogen NOUN B-LF -synthase NOUN I-LF -; PUNCT B-O -GS PROPN B-AC -- PUNCT B-O -p641 NOUN B-O -, PUNCT B-O -phospho NOUN B-O -- PUNCT B-O -glycogen NOUN B-LF -synthase NOUN I-LF -at ADP B-O -S641 NUM B-O -; PUNCT B-O -ITT PROPN B-AC -, PUNCT B-O -insulin NOUN B-LF -tolerance NOUN I-LF -test NOUN I-LF -; PUNCT B-O -Oct1 PROPN B-O -, PUNCT B-O -organic ADJ B-O -cation NOUN B-O -transporter NOUN B-O -1 NUM B-O -; PUNCT B-O -pACC NOUN B-O -, PUNCT B-O -phosphorylate NOUN B-O -acetyl NOUN B-O -- PUNCT B-O -CoA NOUN B-O -carboxylase NOUN B-O -; PUNCT B-O -pAMPK PROPN B-O -, PUNCT B-O -phosphorylate NOUN B-O -5 NUM B-O -' NOUN B-O -adenosine NOUN B-O -monophosphate NOUN B-O -- PUNCT B-O -activated VERB B-O -protein NOUN B-O -kinase NOUN B-O -; PUNCT B-O -PDH PROPN B-AC -, PUNCT B-O -pyruvate NOUN B-LF -dehydrogenase NOUN I-LF -; PUNCT B-O -PDH PROPN B-AC -- PUNCT B-O -p NOUN B-O -, PUNCT B-O -phospho NOUN B-O -- PUNCT B-O -pyruvate NOUN B-LF -dehydrogenase NOUN I-LF -; PUNCT B-O -PTT PROPN B-AC -, PUNCT B-O -pyruvate NOUN B-LF -tolerance NOUN I-LF -test NOUN I-LF -; PUNCT B-O -PYGL PROPN B-AC -; PUNCT B-O -glycogen NOUN B-LF -phosphorylase NOUN I-LF -. PUNCT B-O - -Using VERB B-O -ChIP-qPCR PROPN B-AC -, PUNCT B-O -we PRON B-O -analysed VERB B-O -levels NOUN B-O -of ADP B-O -the DET B-O -active ADJ B-O -- PUNCT B-O -promoter NOUN B-O -– PUNCT B-O -associated VERB B-O -H3K4Me3 PROPN B-AC -mark NOUN B-O -and CCONJ B-O -the DET B-O -polycomb NOUN B-LF -repressor NOUN I-LF -complex NOUN I-LF -( PUNCT B-O -PRC)-associated PROPN B-AC -repressive ADJ B-O -H3K27Me3 PROPN B-AC -mark NOUN B-O -across ADP B-O -the DET B-O -HPV18 PROPN B-O -genome NOUN B-O -. PUNCT B-O - -Criteria NOUN B-O -for ADP B-O -discharge NOUN B-O -were AUX B-O -the DET B-O -absence NOUN B-O -of ADP B-O -fever NOUN B-O -and CCONJ B-O -significant ADJ B-O -symptoms NOUN B-O -for ADP B-O -four NUM B-O -consecutive ADJ B-O -days NOUN B-O -, PUNCT B-O -ability NOUN B-O -to PART B-O -feed VERB B-O -and CCONJ B-O -walk VERB B-O -independently ADV B-O -, PUNCT B-O -and CCONJ B-O -two NUM B-O -consecutive ADJ B-O -negative ADJ B-O -blood NOUN B-O -reverse ADJ B-LF -EBOV PROPN B-AC -transcription NOUN I-LF -PCR NOUN I-LF -( PUNCT B-O -RT PROPN B-AC -) PUNCT B-O -tests NOUN B-O -. PUNCT B-O - -p NOUN B-LF -- NOUN I-LF -p PROPN B-AC -value NOUN I-LF -Statistical PROPN B-LF -Package PROPN I-LF -for ADP I-LF -the DET I-LF -Social PROPN I-LF -Sciences PROPN I-LF -( PUNCT B-O -SPSS PROPN B-AC -17.0 NUM B-O -) PUNCT B-O -was AUX B-O -used VERB B-O -for ADP B-O -all DET B-O -analyses NOUN B-O -. PUNCT B-O - -Length NOUN B-LF -of ADP I-LF -stay NOUN I-LF -( PUNCT B-O -LOS PROPN B-AC -) PUNCT B-O -was AUX B-O -calculated VERB B-O -as ADP B-O -the DET B-O -time NOUN B-O -the DET B-O -disposition NOUN B-O -was AUX B-O -set VERB B-O -to ADP B-O -admit VERB B-O -to ADP B-O -the DET B-O -time NOUN B-O -the DET B-O -subject NOUN B-O -met VERB B-O -the DET B-O -clinical ADJ B-O -criteria NOUN B-O -for ADP B-O -discharge NOUN B-O -. PUNCT B-O - -In ADP B-O -order NOUN B-O -to PART B-O -define VERB B-O -a DET B-O -putative ADJ B-O -olfactory ADJ B-O -space NOUN B-O -for ADP B-O -the DET B-O -honeybee NOUN B-O -, PUNCT B-O -we PRON B-O -performed VERB B-O -a DET B-O -principal ADJ B-LF -component NOUN I-LF -analysis NOUN I-LF -( PUNCT B-O -PCA PROPN B-AC -) PUNCT B-O -on ADP B-O -our PRON B-O -data NOUN B-O -to PART B-O -represent VERB B-O -in ADP B-O -a DET B-O -limited ADJ B-O -number NOUN B-O -of ADP B-O -dimensions NOUN B-O -the DET B-O -relative ADJ B-O -relationships NOUN B-O -between ADP B-O -odorants NOUN B-O -in ADP B-O -a DET B-O -16 NUM B-O -- PUNCT B-O -dimension NOUN B-O -perceptual ADJ B-O -space NOUN B-O -( PUNCT B-O -Figure PROPN B-O -6A NUM B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -first ADJ B-O -three NUM B-O -factors NOUN B-O -represented VERB B-O -31 NUM B-O -% PUNCT B-O -, PUNCT B-O -29 NUM B-O -% PUNCT B-O -, PUNCT B-O -and CCONJ B-O -15 NUM B-O -% PUNCT B-O -of ADP B-O -overall ADJ B-O -variance NOUN B-O -in ADP B-O -the DET B-O -data NOUN B-O -( PUNCT B-O -total NOUN B-O -of ADP B-O -the DET B-O -first ADJ B-O -three NUM B-O -factors NOUN B-O -: PUNCT B-O -75 NUM B-O -% PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -HIV PROPN B-O -epidemic NOUN B-O -is AUX B-O -rapidly ADV B-O -growing VERB B-O -among ADP B-O -men NOUN B-LF -who PRON I-LF -have VERB I-LF -sex NOUN I-LF -with ADP I-LF -men NOUN I-LF -( PUNCT B-O -MSM PROPN B-AC -) PUNCT B-O -in ADP B-O -China PROPN B-O -, PUNCT B-O -yet CCONJ B-O -HIV PROPN B-O -testing NOUN B-O -remains VERB B-O -suboptimal ADJ B-O -. PUNCT B-O - -Quality NOUN B-LF -of ADP I-LF -care NOUN I-LF -was AUX B-O -assessed VERB B-O -using VERB B-O -context NOUN B-O -based VERB B-O -validated VERB B-O -indicators NOUN B-O -which PRON B-O -provide VERB B-O -a DET B-O -more ADV B-O -detailed ADJ B-O -picture NOUN B-O -of ADP B-O -the DET B-O -state NOUN B-O -of ADP B-O -QoC PROPN B-AC -in ADP B-O -the DET B-O -process NOUN B-O -of ADP B-O -childbirth NOUN B-O -. PUNCT B-O - -To PART B-O -understand VERB B-O -the DET B-O -source NOUN B-O -of ADP B-O -ROS PROPN B-AC -and CCONJ B-O -to PART B-O -determine VERB B-O -the DET B-O -association NOUN B-O -of ADP B-O -AngII PROPN B-AC -signaling NOUN B-O -, PUNCT B-O -Klf5 PROPN B-AC -, PUNCT B-O -and CCONJ B-O -eIF5α NOUN B-O -with ADP B-O -NOX PROPN B-AC -expression NOUN B-O -, PUNCT B-O -mouse NOUN B-O -VSMCs PROPN B-AC -were AUX B-O -transfected VERB B-O -with ADP B-O -expression NOUN B-O -vectors NOUN B-O -for ADP B-O -Klf5 PROPN B-AC -and CCONJ B-O -eIF5α NOUN B-O -or CCONJ B-O -small ADJ B-LF -interfering VERB I-LF -RNA NOUN I-LF -( PUNCT B-O -siRNA PROPN B-AC -) PUNCT B-O -against ADP B-O -Klf5 PROPN B-AC -and CCONJ B-O -eIF5α NOUN B-O -, PUNCT B-O -respectively ADV B-O -, PUNCT B-O -and CCONJ B-O -then ADV B-O -treated VERB B-O -with ADP B-O -Ang PROPN B-AC -for ADP B-O -0 NUM B-O -, PUNCT B-O -1 NUM B-O -, PUNCT B-O -3 NUM B-O -, PUNCT B-O -and CCONJ B-O -5 NUM B-O -days NOUN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -expression NOUN B-O -of ADP B-O -NOX1 NOUN B-O -and CCONJ B-O -NOX4 NOUN B-O -was AUX B-O -detected VERB B-O -by ADP B-O -RT NOUN B-O -- PUNCT B-O -qPCR NOUN B-O -. PUNCT B-O - -As SCONJ B-O -shown VERB B-O -in ADP B-O -S17A PROPN B-O -– PUNCT B-O -S17D PROPN B-O -Fig PROPN B-O -, PUNCT B-O -IIAng PROPN B-AC -treatment NOUN B-O -increased VERB B-O -NOX1 NOUN B-O -expression NOUN B-O -, PUNCT B-O -peaked VERB B-O -at ADP B-O -24 NUM B-O -hours NOUN B-O -after ADP B-O -treatment NOUN B-O -, PUNCT B-O -and CCONJ B-O -gradually ADV B-O -declined VERB B-O -thereafter ADV B-O -. PUNCT B-O - -terminal ADJ B-LF -λz PROPN B-AC -slope NOUN I-LF -; PUNCT B-O -AUC0-∞ NOUN B-O -area NOUN B-O -under ADP B-O -the DET B-O -curve NOUN B-O -from ADP B-O -0 NUM B-O -to ADP B-O -infinitive ADJ B-O -; PUNCT B-O -mean ADJ B-LF -MTT PROPN B-AC -transit NOUN I-LF -time NOUN I-LF -; PUNCT B-O -Tmax PROPN B-AC -time NOUN B-O -at ADP B-O -maximum ADJ B-LF -concentration NOUN I-LF -; PUNCT B-O -maximum ADJ B-LF -Cmax PROPN B-AC -concentration NOUN I-LF -; PUNCT B-O -F NOUN B-O -bioavailability NOUN B-O -, PUNCT B-O -was AUX B-O -calculated VERB B-O -by ADP B-O -dividing VERB B-O -the DET B-O -ratio NOUN B-O -of ADP B-O -AUC0-∞ NOUN B-O -oral ADJ B-O -by ADP B-O -the DET B-O -dose NOUN B-O -and CCONJ B-O -by ADP B-O -ratio NOUN B-O -total ADJ B-O -PTA PROPN B-AC -AUC0-∞ NOUN B-O -IV NOUN B-O -by ADP B-O -respective ADJ B-O -dose NOUN B-O -. PUNCT B-O - -The DET B-O -figure NOUN B-O -illustrates VERB B-O -ErbB PROPN B-O -signaling NOUN B-O -pathway NOUN B-O -that PRON B-O -contain VERB B-O -genes NOUN B-O -that PRON B-O -are AUX B-O -targeted VERB B-O -by ADP B-O -miRNAs PROPN B-AC -which PRON B-O -regulate VERB B-O -NMT PROPN B-AC -gene NOUN B-O -. PUNCT B-O - -( PUNCT B-O -EGF PROPN B-O -, PUNCT B-O -epidermal ADJ B-O -growth NOUN B-O -factor NOUN B-O -; PUNCT B-O -TGF PROPN B-O -, PUNCT B-O -transforming VERB B-O -growth NOUN B-O -factor NOUN B-O -; PUNCT B-O -BTC PROPN B-O -, PUNCT B-O -betacellulin NOUN B-O -; PUNCT B-O -HB PROPN B-O -- PUNCT B-O -EGF PROPN B-O -, PUNCT B-O -heparin NOUN B-O -- PUNCT B-O -binding VERB B-O -epidermal ADJ B-O -growth NOUN B-O -factor NOUN B-O -( PUNCT B-O -EGF)-like PROPN B-O -growth NOUN B-O -factor NOUN B-O -; PUNCT B-O -EREG PROPN B-O -, PUNCT B-O -epiregulin NOUN B-O -; PUNCT B-O -NRG1 PROPN B-O -, PUNCT B-O -neuregulin-1 NOUN B-O -; PUNCT B-O -NRG2 PROPN B-O -, PUNCT B-O -neuregulin-2 NOUN B-O -; PUNCT B-O -NRG3 PROPN B-O -, PUNCT B-O -neuregulin-3 NOUN B-O -; PUNCT B-O -NRG4 PROPN B-O -, PUNCT B-O -neuregulin-4 NOUN B-O -; PUNCT B-O -PLCγ PROPN B-O -, PUNCT B-O -phospholipase NOUN B-O -C PROPN B-O -type NOUN B-O -gamma NOUN B-O -; PUNCT B-O -CAMK2B PROPN B-O -, PUNCT B-O -calcium NOUN B-O -/ SYM B-O -calmodulin NOUN B-O -dependent ADJ B-O -protein NOUN B-O -kinase NOUN B-O -; PUNCT B-O -PRKCB PROPN B-O -, PUNCT B-O -Protein PROPN B-O -kinase NOUN B-O -C PROPN B-O -- PUNCT B-O -beta NOUN B-O -; PUNCT B-O -STAT5 PROPN B-O -, PUNCT B-O -Signal NOUN B-O -transducer NOUN B-O -and CCONJ B-O -activator NOUN B-O -of ADP B-O -transcription NOUN B-O -5 NUM B-O -; PUNCT B-O -src PROPN B-O -, PUNCT B-O -Rous PROPN B-O -sarcoma NOUN B-O -virus NOUN B-O -gene NOUN B-O -; PUNCT B-O -CRK PROPN B-O -, PUNCT B-O -C PROPN B-O -T10 NOUN B-O -regulator NOUN B-O -of ADP B-O -a DET B-O -tyrosine NOUN B-O -kinase NOUN B-O -; PUNCT B-O -NCL PROPN B-O -, PUNCT B-O -NCK PROPN B-O -Adaptor PROPN B-O -Protein PROPN B-O -2 NUM B-O -; PUNCT B-O -PTK2 PROPN B-O -, PUNCT B-O -PTK2 PROPN B-O -protein NOUN B-O -tyrosine NOUN B-O -kinase NOUN B-O -2 NUM B-O -; PUNCT B-O -ABL2 PROPN B-O -, PUNCT B-O -V PROPN B-O -- PUNCT B-O -Abl PROPN B-O -Abelson PROPN B-O -Murine PROPN B-O -Leukemia PROPN B-O -Viral PROPN B-O -Oncogene PROPN B-O -Homolog PROPN B-O -2 NUM B-O -; PUNCT B-O -PAK2 PROPN B-O -, PUNCT B-O -P21 PROPN B-O -( PUNCT B-O -RAC1 PROPN B-O -) PUNCT B-O -Activated PROPN B-O -Kinase PROPN B-O -2 NUM B-O -; PUNCT B-O -MAP2K4 PROPN B-O -, PUNCT B-O -Mitogen PROPN B-O -- PUNCT B-O -Activated PROPN B-O -Protein PROPN B-O -Kinase PROPN B-O -Kinase PROPN B-O -4 NUM B-O -; PUNCT B-O -MAPK10 PROPN B-O -, PUNCT B-O -Mitogen PROPN B-O -- PUNCT B-O -Activated PROPN B-O -Protein PROPN B-O -Kinase PROPN B-O -10 NUM B-O -; PUNCT B-O -SOS1 PROPN B-O -, PUNCT B-O -SOS PROPN B-O -Ras PROPN B-O -/ SYM B-O -Rac NOUN B-O -Guanine NOUN B-O -Nucleotide PROPN B-O -Exchange PROPN B-O -Factor PROPN B-O -1 NUM B-O -; PUNCT B-O -Grb2 PROPN B-O -, PUNCT B-O -Growth NOUN B-O -Factor PROPN B-O -Receptor NOUN B-O -Bound PROPN B-O -Protein PROPN B-O -2 NUM B-O -; PUNCT B-O -SHC4 PROPN B-O -, PUNCT B-O -Src NOUN B-O -Homology NOUN B-O -2 NUM B-O -Domain NOUN B-O -- PUNCT B-O -Containing VERB B-O -- PUNCT B-O -Transforming VERB B-O -Protein PROPN B-O -C4 PROPN B-O -; PUNCT B-O -PIK3C4 PROPN B-O -, PUNCT B-O -Phosphatidylinositol-4,5 NOUN B-O -- PUNCT B-O -Bisphosphate NOUN B-O -3 NUM B-O -- PUNCT B-O -Kinase PROPN B-O -Catalytic PROPN B-O -Subunit PROPN B-O -; PUNCT B-O -AKT3 PROPN B-O -, PUNCT B-O -KT PROPN B-O -Serine NOUN B-O -/ SYM B-O -Threonine NOUN B-O -Kinase PROPN B-O -3 NUM B-O -; PUNCT B-O -mTOR NOUN B-O -, PUNCT B-O -Mechanistic ADJ B-O -Target NOUN B-O -Of ADP B-O -Rapamycin NOUN B-O -Kinase PROPN B-O -; PUNCT B-O -BCL2 PROPN B-O -, PUNCT B-O -BCL2 PROPN B-O -Associated ADJ B-O -Agonist NOUN B-O -Of ADP B-O -Cell NOUN B-O -Death NOUN B-O -; PUNCT B-O -GSK3B PROPN B-AC -, PUNCT B-O -Glycogen NOUN B-LF -Synthase NOUN I-LF -Kinase PROPN I-LF -3 NUM I-LF -Beta PROPN I-LF -; PUNCT B-O -CDKN1A PROPN B-O -, PUNCT B-O -Cyclin NOUN B-O -Dependent PROPN B-O -Kinase PROPN B-O -Inhibitor PROPN B-O -1A PROPN B-O -; PUNCT B-O -EIF4EBP1 PROPN B-O -, PUNCT B-O -Eukaryotic ADJ B-O -Translation NOUN B-O -Initiation PROPN B-O -Factor PROPN B-O -4E NUM B-O -Binding PROPN B-O -Protein PROPN B-O -1 NUM B-O -; PUNCT B-O -BRAF PROPN B-AC -, PUNCT B-O -B PROPN B-LF -- PUNCT I-LF -Raf PROPN I-LF -Proto PROPN I-LF -- PUNCT I-LF -Oncogene PROPN I-LF -, PUNCT B-O -Serine NOUN B-O -/ SYM B-O -Threonine NOUN B-O -Kinase PROPN B-O -; PUNCT B-O -RPS6KB1 PROPN B-O -, PUNCT B-O -Ribosomal PROPN B-O -Protein PROPN B-O -S6 PROPN B-O -Kinase PROPN B-O -B1 PROPN B-O -; PUNCT B-O -KRAS PROPN B-O -, PUNCT B-O -KRAS PROPN B-O -Proto PROPN B-O -- PUNCT B-O -Oncogene PROPN B-O -, PUNCT B-O -GTPase PROPN B-O -; PUNCT B-O -JUN PROPN B-O -, PUNCT B-O -Jun PROPN B-O -Proto PROPN B-O -- PUNCT B-O -Oncogene PROPN B-O -, PUNCT B-O -AP-1 PROPN B-O -Transcription PROPN B-O -Factor PROPN B-O -Subunit PROPN B-O -; PUNCT B-O -ELK PROPN B-O -, PUNCT B-O -ETS PROPN B-O -Transcription PROPN B-O -Factor PROPN B-O -; PUNCT B-O -Myc PROPN B-O -, PUNCT B-O -MYC PROPN B-O -Proto PROPN B-O -- PUNCT B-O -Oncogene PROPN B-O -, PUNCT B-O -BHLH PROPN B-O -Transcription PROPN B-O -Factor PROPN B-O -; PUNCT B-O -ER PROPN B-O -, PUNCT B-O -endoplasmic ADJ B-O -reticulum NOUN B-O -. PUNCT B-O - -To PART B-O -determine VERB B-O -whether SCONJ B-O -such ADJ B-O -target NOUN B-O -proteins NOUN B-O -could AUX B-O -be AUX B-O -identified VERB B-O -for ADP B-O -Ginir PROPN B-AC -RNA NOUN B-O -, PUNCT B-O -we PRON B-O -followed VERB B-O -the DET B-O -approach NOUN B-O -of ADP B-O -using VERB B-O -biotin NOUN B-O -- PUNCT B-O -labelled VERB B-O -RNA NOUN B-O -affinity NOUN B-O -pull VERB B-O -- PUNCT B-O -down NOUN B-O -and CCONJ B-O -RNA NOUN B-LF -- PUNCT I-LF -immunoprecipitation NOUN I-LF -( PUNCT B-O -RIP PROPN B-AC -) PUNCT B-O -assays NOUN B-O -. PUNCT B-O - -This DET B-O -hyperphosphorylation NOUN B-O -causes VERB B-O -light NOUN B-O -- PUNCT B-O -dependent ADJ B-O -retinal ADJ B-O -degeneration NOUN B-O -and CCONJ B-O -premature ADJ B-O -entrance NOUN B-O -into ADP B-O -the DET B-O -prolonged VERB B-LF -depolarizing VERB I-LF -afterpotential NOUN I-LF -( PUNCT B-O -PDA PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -1–3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Sirius PROPN B-O -red ADJ B-O -staining NOUN B-O -revealed VERB B-O -significantly ADV B-O -more ADJ B-O -collagen NOUN B-O -deposition NOUN B-O -in ADP B-O -the DET B-O -F-BCA PROPN B-AC -adipose ADJ B-O -tissues NOUN B-O -, PUNCT B-O -particularly ADV B-O -around ADP B-O -the DET B-O -SVF PROPN B-AC -zones NOUN B-O -( PUNCT B-O -Fig NUM B-O -6A NUM B-O -) PUNCT B-O -. PUNCT B-O - -More ADV B-O -abundant ADJ B-O -type NOUN B-LF -I NOUN I-LF -collagen NOUN I-LF -( PUNCT B-O -ColI PROPN B-AC -) PUNCT B-O -expression NOUN B-O -was AUX B-O -detected VERB B-O -in ADP B-O -the DET B-O -F PROPN B-AC --BCASVF PROPN B-AC -cells NOUN B-O -( PUNCT B-O -Fig NUM B-O -6B NUM B-O -) PUNCT B-O -, PUNCT B-O -although SCONJ B-O -the DET B-O -mRNA NOUN B-O -levels NOUN B-O -were AUX B-O -unchanged ADJ B-O -upon SCONJ B-O -activation NOUN B-O -of ADP B-O -canonical ADJ B-O -Wnt NOUN B-O -signaling NOUN B-O -in ADP B-O -the DET B-O -FSP1 PROPN B-AC -+ NOUN B-O -fibroblasts NOUN B-O -( PUNCT B-O -Fig NUM B-O -6C NUM B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -matrix NOUN B-LF -metalloproteinase NOUN I-LF -( PUNCT B-O -MMP PROPN B-AC -) PUNCT B-O -family NOUN B-O -is AUX B-O -primarily ADV B-O -responsible ADJ B-O -for ADP B-O -the DET B-O -degradation NOUN B-O -and CCONJ B-O -remodeling NOUN B-O -of ADP B-O -extracellular ADJ B-O -matrix NOUN B-O -[ PUNCT B-O -6,21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -After ADP B-O -heat NOUN B-O -antigen NOUN B-O -retrieval NOUN B-O -using VERB B-O -sodium NOUN B-O -citrate NOUN B-O -buffer NOUN B-O -, PUNCT B-O -brain NOUN B-O -sections NOUN B-O -were AUX B-O -incubated VERB B-O -with ADP B-O -blocking VERB B-O -buffer NOUN B-O -( PUNCT B-O -10 NUM B-O -% NOUN B-O -Normal PROPN B-O -Goat PROPN B-O -Serum PROPN B-O -, PUNCT B-O -1 NUM B-O -% NOUN B-O -BSA PROPN B-O -, PUNCT B-O -and CCONJ B-O -3 NUM B-O -M NOUN B-O -Glycine PROPN B-O -in ADP B-O -TBS-0.1 NUM B-O -% NOUN B-O -Triton PROPN B-O -- PUNCT B-O -X PROPN B-O -) PUNCT B-O -for ADP B-O -1 NUM B-O -hour NOUN B-O -at ADP B-O -room NOUN B-LF -temperature NOUN I-LF -( PUNCT B-O -RT PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -After ADP B-O -blocking VERB B-O -, PUNCT B-O -antibodies NOUN B-O -were AUX B-O -diluted VERB B-O -in ADP B-O -blocking VERB B-O -buffer NOUN B-O -and CCONJ B-O -incubated VERB B-O -overnight ADV B-O -at ADP B-O -4 NUM B-O -° NOUN B-O -C NOUN B-O -. PUNCT B-O - -Healthy ADJ B-LF -controls NOUN I-LF -( PUNCT B-O -HC PROPN B-AC -): PUNCT B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -59 NUM B-O -) PUNCT B-O -21 NUM B-O -adult NOUN B-O -healthy ADJ B-LF -controls NOUN I-LF -and CCONJ B-O -38 NUM B-O -children NOUN B-O -older ADJ B-O -than ADP B-O -4 NUM B-O -were AUX B-O -included VERB B-O -in ADP B-O -Study NOUN B-O -2 NUM B-O -. PUNCT B-O - -Primaquine PROPN B-LF -( PUNCT B-O -PQ PROPN B-AC -) PUNCT B-O -has AUX B-O -been AUX B-O -used VERB B-O -for ADP B-O -over ADP B-O -65 NUM B-O -years NOUN B-O -and CCONJ B-O -is AUX B-O -currently ADV B-O -the DET B-O -only ADJ B-O -widely ADV B-O -available ADJ B-O -hypnozoitocidal ADJ B-O -drug NOUN B-O -for ADP B-O -P. PROPN B-O -vivax PROPN B-O -and CCONJ B-O -P. PROPN B-O -ovale PROPN B-O -. PUNCT B-O - -A DET B-O -recent ADJ B-O -report NOUN B-O -suggests VERB B-O -that SCONJ B-O -SDF-1 PROPN B-O -promotes VERB B-O -epidermal ADJ B-LF -stem NOUN I-LF -cell NOUN I-LF -( PUNCT B-O -ESC PROPN B-AC -) PUNCT B-O -migration NOUN B-O -and CCONJ B-O -accelerates VERB B-O -wound NOUN B-O -healing NOUN B-O -in ADP B-O -vivo ADV B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Extracted VERB B-O -peptides NOUN B-O -were AUX B-O -analysed VERB B-O -by ADP B-O -liquid NOUN B-LF -chromatography NOUN I-LF -– PUNCT I-LF -tandem NOUN I-LF -mass NOUN I-LF -spectrometry NOUN I-LF -( PUNCT B-O -LC–MS/MS PROPN B-AC -) PUNCT B-O -with ADP B-O -the DET B-O -Orbitrap PROPN B-O -Fusion PROPN B-O -mass NOUN B-O -spectrometer NOUN B-O -and CCONJ B-O -nanoflow NOUN B-O -- PUNCT B-O -HPLC NOUN B-O -system NOUN B-O -U3000 PROPN B-O -( PUNCT B-O -Thermo PROPN B-O -Fisher PROPN B-O -Scientific PROPN B-O -, PUNCT B-O -UK PROPN B-O -) PUNCT B-O -[ PUNCT B-O -48,50 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This DET B-O -study NOUN B-O -aimed VERB B-O -to PART B-O -assess VERB B-O -the DET B-O -comparability NOUN B-O -among ADP B-O -assays NOUN B-O -using VERB B-O -freshly ADV B-O -frozen VERB B-O -human ADJ B-O -sera NOUN B-O -and CCONJ B-O -external ADJ B-LF -quality NOUN I-LF -assessment NOUN I-LF -( PUNCT B-O -EQA PROPN B-AC -) PUNCT B-O -data NOUN B-O -in ADP B-O -China PROPN B-O -. PUNCT B-O - -The DET B-O -“ PUNCT B-O -gold NOUN B-O -standard NOUN B-O -” PUNCT B-O -for ADP B-O -NACT PROPN B-AC -response NOUN B-O -was AUX B-O -the DET B-O -5 NUM B-O -- PUNCT B-O -years NOUN B-O -relapse NOUN B-LF -free ADJ I-LF -survival NOUN I-LF -( PUNCT B-O -RFS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -as SCONJ B-O -it PRON B-O -provides VERB B-O -a DET B-O -reasonable ADJ B-O -threshold NOUN B-O -to ADP B-O -capture VERB B-O -all DET B-O -relapses NOUN B-O -related VERB B-O -to ADP B-O -NACT PROPN B-AC -response NOUN B-O -[ PUNCT B-O -11 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -ATP PROPN B-LF -- PUNCT I-LF -binding VERB I-LF -cassette NOUN I-LF -transporter NOUN I-LF -A1 NOUN I-LF -( PUNCT B-O -ABCA1 PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -cholesterol NOUN B-O -and CCONJ B-O -phospholipid NOUN B-O -transporter NOUN B-O -, PUNCT B-O -and CCONJ B-O -mutations NOUN B-O -in ADP B-O -ABCA1 PROPN B-AC -cause VERB B-O -Tangier PROPN B-LF -disease NOUN I-LF -( PUNCT B-O -TD PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -1–3 NUM B-O -] PUNCT B-O -, PUNCT B-O -a DET B-O -rare ADJ B-O -disorder NOUN B-O -characterized VERB B-O -by ADP B-O -reduced VERB B-O -levels NOUN B-O -of ADP B-O -plasma NOUN B-O -high ADJ B-LF -density NOUN I-LF -lipoprotein NOUN I-LF -( PUNCT B-O -HDL PROPN B-AC -) PUNCT B-O -cholesterol NOUN B-O -and CCONJ B-O -increased VERB B-O -risk NOUN B-O -for ADP B-O -coronary ADJ B-O -artery NOUN B-O -disease NOUN B-O -[ PUNCT B-O -4 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -neonatal ADJ B-LF -mortality NOUN I-LF -rate NOUN I-LF -( PUNCT B-O -NMR PROPN B-AC -) PUNCT B-O -has AUX B-O -declined VERB B-O -markedly ADV B-O -in ADP B-O -recent ADJ B-O -years NOUN B-O -in ADP B-O -Tanzania PROPN B-O -but CCONJ B-O -varies VERB B-O -widely ADV B-O -across ADP B-O -the DET B-O -country NOUN B-O -. PUNCT B-O - -HSV-2 PROPN B-AC -, PUNCT B-O -herpes NOUN B-LF -simplex NOUN I-LF -virus NOUN I-LF -type NOUN I-LF -2 NUM I-LF -; PUNCT B-O -STI PROPN B-AC -, PUNCT B-O -sexually ADV B-LF -transmitted VERB I-LF -infection NOUN I-LF -. PUNCT B-O - -Eight NUM B-O -databases NOUN B-O -, PUNCT B-O -PubMed PROPN B-O -, PUNCT B-O -GWAS PROPN B-AC -, PUNCT B-O -Embase PROPN B-O -, PUNCT B-O -Lochrane PROPN B-O -, PUNCT B-O -Ebsco PROPN B-O -, PUNCT B-O -CNKI PROPN B-AC -( PUNCT B-O -Chinese PROPN B-LF -National PROPN I-LF -Knowledge PROPN I-LF -Infrastructure PROPN I-LF -) PUNCT B-O -, PUNCT B-O -VIP PROPN B-AC -( PUNCT B-O -Viper PROPN B-LF -Database PROPN I-LF -) PUNCT B-O -and CCONJ B-O -ChinaInfo PROPN B-O -were AUX B-O -searched VERB B-O -, PUNCT B-O -and CCONJ B-O -a DET B-O -meta NOUN B-O -- NOUN B-O -analysis NOUN B-O -of ADP B-O -susceptibility NOUN B-O -was AUX B-O -conducted VERB B-O -between ADP B-O -SNP45 NOUN B-O -, PUNCT B-O -SNP276 NOUN B-O -polymorphisms NOUN B-O -and CCONJ B-O -T2DM PROPN B-AC -. PUNCT B-O - -Furthermore ADV B-O -, PUNCT B-O -HWE PROPN B-AC -test NOUN B-O -was AUX B-O -conducted VERB B-O -to PART B-O -assess VERB B-O -the DET B-O -genetic ADJ B-O -balance NOUN B-O -of ADP B-O -the DET B-O -study NOUN B-O -, PUNCT B-O -evaluate VERB B-O -the DET B-O -quality NOUN B-O -of ADP B-O -Newcastle PROPN B-LF -– PUNCT I-LF -Ottawa PROPN I-LF -quality NOUN I-LF -assessment NOUN I-LF -scale NOUN I-LF -( PUNCT B-O -NOS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -establishing VERB B-O -allelic ADJ B-O -, PUNCT B-O -dominant ADJ B-O -, PUNCT B-O -recessive ADJ B-O -, PUNCT B-O -heterozygous ADJ B-O -, PUNCT B-O -and CCONJ B-O -homozygous ADJ B-O -gene NOUN B-O -models NOUN B-O -. PUNCT B-O - -The DET B-O -carbohydrate NOUN B-O -composition NOUN B-O -of ADP B-O -the DET B-O -extracts NOUN B-O -was AUX B-O -analysed VERB B-O -using VERB B-O -polysaccharide NOUN B-LF -analysis NOUN I-LF -by ADP I-LF -carbohydrate NOUN I-LF -gel NOUN I-LF -electrophoresis NOUN I-LF -( PUNCT B-O -PACE PROPN B-AC -) PUNCT B-O -and CCONJ B-O -high ADJ B-O -- NOUN B-O -performance NOUN B-O -anion NOUN B-O -- NOUN B-O -exchange NOUN B-O -chromatography NOUN B-O -( PUNCT B-O -HPAEC PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Whether SCONJ B-O -there PRON B-O -were VERB B-O -any DET B-O -proteinaceous ADJ B-O -moieties NOUN B-O -linked VERB B-O -to ADP B-O -β PUNCT B-O -- NOUN B-O -glucan NOUN B-O -was AUX B-O -also ADV B-O -examined VERB B-O -. PUNCT B-O - -Wild ADJ B-O -- PUNCT B-O -type NOUN B-O -( PUNCT B-O -WT PROPN B-AC -) PUNCT B-O -Salmonella NOUN B-O -was AUX B-O -electroporated VERB B-O -with ADP B-O -6 NUM B-O -μM PROPN B-O -I NOUN B-O -- PUNCT B-O -switch NOUN B-O -and CCONJ B-O -recovered VERB B-O -in ADP B-O -SOC PROPN B-O -for ADP B-O -1 NUM B-O -h NOUN B-O -at ADP B-O -37 NUM B-O -° NOUN B-O -C NOUN B-O -, PUNCT B-O -followed VERB B-O -by ADP B-O -three NUM B-O -washes NOUN B-O -with ADP B-O -PBS PROPN B-O -. PUNCT B-O - -Bacteria NOUN B-O -were AUX B-O -then ADV B-O -clamped VERB B-O -at ADP B-O -various ADJ B-O -pH NOUN B-O -values NOUN B-O -in ADP B-O -K+-rich NOUN B-O -buffer NOUN B-O -containing VERB B-O -40 NUM B-O -μM PROPN B-O -nigericin NOUN B-O -for ADP B-O -1 NUM B-O -h NOUN B-O -at ADP B-O -room NOUN B-LF -temperature NOUN I-LF -( PUNCT B-O -RT PROPN B-AC -) PUNCT B-O -and CCONJ B-O -imaged VERB B-O -on ADP B-O -an DET B-O -Applied PROPN B-O -Precision PROPN B-O -Delta PROPN B-O -Vision PROPN B-O -inverted VERB B-O -wide ADJ B-O -- PUNCT B-O -field NOUN B-O -fluorescence NOUN B-O -microscope NOUN B-O -. PUNCT B-O - -Protein NOUN B-O -export NOUN B-O -via ADP B-O -both DET B-O -fT3SS PROPN B-AC -and CCONJ B-O -vT3SS PROPN B-AC -is AUX B-O -primarily ADV B-O -dependent ADJ B-O -on ADP B-O -the DET B-O -proton NOUN B-LF -motive NOUN I-LF -force NOUN I-LF -( PUNCT B-O -pmf PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -5–9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -CPM PROPN B-AC -, PUNCT B-O -counts NOUN B-LF -per ADP I-LF -minute NOUN I-LF -; PUNCT B-O -CRF PROPN B-AC -, PUNCT B-O -cardiorespiratory ADJ B-LF -fitness NOUN I-LF -; PUNCT B-O -CI PROPN B-O -, PUNCT B-O -confidence NOUN B-O -interval NOUN B-O -. PUNCT B-O - -The DET B-O -standard ADJ B-O -test NOUN B-O -for ADP B-O -infection NOUN B-O -is AUX B-O -the DET B-O -tuberculin NOUN B-LF -skin NOUN I-LF -test NOUN I-LF -( PUNCT B-O -TST PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -this PRON B-O -, PUNCT B-O -bacterial ADJ B-O -antigens NOUN B-O -( PUNCT B-O -proteins NOUN B-O -that PRON B-O -the DET B-O -immune ADJ B-O -system NOUN B-O -recognize VERB B-O -as ADP B-O -foreign ADJ B-O -) PUNCT B-O -are AUX B-O -injected VERB B-O -under ADP B-O -the DET B-O -skin NOUN B-O -. PUNCT B-O - -No PROPN B-O -, PUNCT B-O -core NOUN B-O -number NOUN B-O -; PUNCT B-O -Dx NOUN B-O -, PUNCT B-O -diagnosis NOUN B-O -; PUNCT B-O -ILC PROPN B-AC -, PUNCT B-O -invasive ADJ B-LF -lobular ADJ I-LF -carcinoma NOUN I-LF -; PUNCT B-O -ITC PROPN B-AC -, PUNCT B-O -invasive ADJ B-LF -tubular ADJ I-LF -carcinoma NOUN I-LF -; PUNCT B-O -+ NUM B-O -, PUNCT B-O -positive ADJ B-O -; PUNCT B-O -EXP PROPN B-AC -, PUNCT B-O -expression NOUN B-LF -; PUNCT B-O -INTPN PROPN B-AC -, PUNCT B-O -interpretation NOUN B-LF -after ADP B-O -considering VERB B-O -the DET B-O -1 NUM B-O -+ NUM B-O -intensity NOUN B-O -( PUNCT B-O -2a NUM B-O -) PUNCT B-O -as ADP B-O -negative ADJ B-O -; PUNCT B-O -LC PROPN B-AC -, PUNCT B-O -lymphocyte NOUN B-LF -; PUNCT B-O -NS PROPN B-AC -, PUNCT B-O -no DET B-LF -lymphocytes NOUN B-LF -seen VERB I-LF -Ab PROPN B-AC -, PUNCT B-O -antibody NOUN B-LF -; PUNCT B-O -Iso PROPN B-O -, PUNCT B-O -Isotype PROPN B-O -control NOUN B-O -. PUNCT B-O - -STAT3 PROPN B-AC -decoy NOUN B-O -was AUX B-O -loaded VERB B-O -on ADP B-O -cationic ADJ B-O -lipid NOUN B-O -microbubbles NOUN B-LF -( PUNCT B-O -STAT3 PROPN B-AC -) PUNCT B-O -or CCONJ B-O -loaded VERB B-O -on ADP B-O -liposome NOUN B-O -- PUNCT B-O -conjugated VERB B-O -lipid NOUN B-O -microbubbles NOUN B-LF -to PART B-O -form VERB B-O --MBSTAT3 PROPN B-AC -- PUNCT B-O -loaded VERB B-O -liposome NOUN B-O -- PUNCT B-O -microbubble NOUN B-LF -complexes NOUN B-O -( PUNCT B-O -STAT3 PROPN B-AC -) PUNCT B-O -. PUNCT B-O - --LPXUTMC PROPN B-AC -treatment NOUN B-O -efficacy NOUN B-O -with ADP B-O -these DET B-O -two NUM B-O -formulations NOUN B-O -was AUX B-O -evaluated VERB B-O -in ADP B-O -vitro ADV B-O -using VERB B-O -viability NOUN B-O -and CCONJ B-O -apoptosis NOUN B-O -assays NOUN B-O -in ADP B-O -CAL33 PROPN B-O -( PUNCT B-O -human ADJ B-O -HNSCC PROPN B-AC -) PUNCT B-O -cells NOUN B-O -. PUNCT B-O - -BF PROPN B-O -, PUNCT B-O -Burkina PROPN B-O -Faso PROPN B-O -; PUNCT B-O -DRC PROPN B-AC -, PUNCT B-O -Democratic PROPN B-LF -Republic PROPN I-LF -of ADP I-LF -the DET I-LF -Congo PROPN I-LF -; PUNCT B-O -EMEP PROPN B-O -, PUNCT B-O -Evaluation NOUN B-O -of ADP B-O -Medications NOUN B-O -used VERB B-O -in ADP B-O -Early PROPN B-O -Pregnancy NOUN B-O -; PUNCT B-O -GA PROPN B-O -, PUNCT B-O -gestational ADJ B-O -age NOUN B-O -; PUNCT B-O -IPTp PROPN B-AC -, PUNCT B-O -intermittent ADJ B-LF -preventive ADJ I-LF -treatment NOUN I-LF -in ADP I-LF -pregnancy NOUN I-LF -; PUNCT B-O -ITN PROPN B-O -, PUNCT B-O -insecticide NOUN B-O -- PUNCT B-O -treated VERB B-O -bed NOUN B-O -nets NOUN B-O -; PUNCT B-O -M3 PROPN B-AC -, PUNCT B-O -Maternal PROPN B-LF -Malaria NOUN I-LF -and CCONJ I-LF -Malnutrition PROPN I-LF -; PUNCT B-O -PNG PROPN B-AC -, PUNCT B-O -Papua PROPN B-LF -New PROPN I-LF -Guinea PROPN I-LF -; PUNCT B-O -STOPPAM PROPN B-O -, PUNCT B-O -Strategies NOUN B-O -to PART B-O -Prevent VERB B-O -Pregnancy NOUN B-O -- PUNCT B-O -Associated VERB B-O -Malaria NOUN B-O -. PUNCT B-O - -The DET B-O -prognostic ADJ B-O -values NOUN B-O -of ADP B-O -left ADJ B-LF -ventricular ADJ I-LF -ejection NOUN I-LF -fraction NOUN I-LF -( PUNCT B-O -LVEF PROPN B-AC -) PUNCT B-O -during ADP B-O -heart NOUN B-LF -failure NOUN I-LF -( PUNCT B-O -HF PROPN B-AC -) PUNCT B-O -with ADP B-O -acute ADJ B-O -decompensation NOUN B-O -or CCONJ B-O -after ADP B-O -optimal ADJ B-O -treatment NOUN B-O -have AUX B-O -not PART B-O -been AUX B-O -extensively ADV B-O -studied VERB B-O -. PUNCT B-O - -( PUNCT B-O -Photo- ADJ B-O -) PUNCT B-O -chemical ADJ B-O -cross ADJ B-O -- ADJ B-O -linking ADJ B-O -combined VERB B-O -with ADP B-O -mass NOUN B-LF -spectrometry NOUN I-LF -( PUNCT B-O -MS PROPN B-AC -) PUNCT B-O -has AUX B-O -evolved VERB B-O -as ADP B-O -an DET B-O -alternative ADJ B-O -method NOUN B-O -to PART B-O -obtain VERB B-O -low ADJ B-O -- ADJ B-O -resolution NOUN B-O -three NUM B-O -- ADJ B-O -dimensional ADJ B-O -( PUNCT B-O -3D ADJ B-O -) PUNCT B-O -structural ADJ B-O -information NOUN B-O -of ADP B-O -proteins NOUN B-O -and CCONJ B-O -protein NOUN B-O -complexes.[1–9 NUM B-O -] PUNCT B-O -The DET B-O -cross ADJ B-O -- ADJ B-O -linking ADJ B-O -/ SYM B-O -MS PROPN B-AC -approach NOUN B-O -allows VERB B-O -deriving VERB B-O -structural ADJ B-O -information NOUN B-O -by ADP B-O -covalently ADV B-O -connecting VERB B-O -pairs NOUN B-O -of ADP B-O -functional ADJ B-O -groups NOUN B-O -in ADP B-O -the DET B-O -protein(s NOUN B-O -) PUNCT B-O -under ADP B-O -investigation NOUN B-O -. PUNCT B-O - -The DET B-O -widespread ADJ B-O -presence NOUN B-O -of ADP B-O -overweight NOUN B-O -and CCONJ B-O -obesity NOUN B-O -increases VERB B-O -with ADP B-O -every DET B-O -decade NOUN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -number NOUN B-O -of ADP B-O -people NOUN B-O -with ADP B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -> ADP B-O -30 NUM B-O -kg NOUN B-O -/ SYM B-O -m2 NOUN B-O -has AUX B-O -doubled VERB B-O -in ADP B-O -the DET B-O -last ADJ B-O -30 NUM B-O -years NOUN B-O -. PUNCT B-O - -Effect NOUN B-O -of ADP B-O -mitoCCCP PROPN B-AC -and CCONJ B-O -CCCP PROPN B-AC -on ADP B-O -the DET B-O -pH NOUN B-O -gradient NOUN B-O -across ADP B-O -the DET B-O -membranes NOUN B-O -of ADP B-O -submitochondrial ADJ B-LF -particles NOUN I-LF -( PUNCT B-O -SMP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -as SCONJ B-O -measured VERB B-O -by ADP B-O -ACMA PROPN B-AC -( PUNCT B-O -0.5 NUM B-O -μg NOUN B-O -/ SYM B-O -ml NOUN B-O -) PUNCT B-O -fluorescence NOUN B-O -. PUNCT B-O - -Within ADP B-O -the DET B-O -DOT PROPN B-AC -- PUNCT B-O -group NOUN B-O -, PUNCT B-O -SVR12 PROPN B-O -was AUX B-O -achieved VERB B-O -in ADP B-O -99.1 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -: PUNCT B-O -95.0–100 NUM B-O -; PUNCT B-O -n NOUN B-O -= SYM B-O -109/110 NUM B-O -) PUNCT B-O -with ADP B-O -one NUM B-O -patient NOUN B-O -experiencing VERB B-O -treatment NOUN B-O -failure NOUN B-O -, PUNCT B-O -while SCONJ B-O -n NOUN B-O -= SYM B-O -12/122 NUM B-O -( PUNCT B-O -9.8 NUM B-O -% NOUN B-O -) PUNCT B-O -patients NOUN B-O -were AUX B-O -excluded VERB B-O -due ADP B-O -to ADP B-O -loss NOUN B-O -of ADP B-O -follow NOUN B-LF -- PUNCT I-LF -up NOUN I-LF -( PUNCT B-O -FU PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -5 NUM B-O -patients NOUN B-O -showed VERB B-O -HCV PROPN B-AC -reinfection NOUN B-O -after ADP B-O -achieving VERB B-O -SVR12 PROPN B-O -. PUNCT B-O - -We PRON B-O -assumed VERB B-O -that PRON B-O -lung NOUN B-O -tissues NOUN B-O -are AUX B-O -protected VERB B-O -from ADP B-O -overactive ADJ B-O -immune ADJ B-O -cells NOUN B-O -by ADP B-O -the DET B-O -same ADJ B-O -hypoxia NOUN B-O -- PUNCT B-O -driven VERB B-O -mechanism NOUN B-O -and CCONJ B-O -immunosuppressive ADJ B-O -adenosine NOUN B-LF -A2A NOUN I-LF -receptor NOUN I-LF -( PUNCT B-O -A2AR)-mediated PROPN B-AC -mechanism NOUN B-O -that PRON B-O -was AUX B-O -recently ADV B-O -shown VERB B-O -to PART B-O -play VERB B-O -a DET B-O -critical ADJ B-O -role NOUN B-O -in ADP B-O -the DET B-O -down NOUN B-O -- PUNCT B-O -regulation NOUN B-O -of ADP B-O -inflammation NOUN B-O -and CCONJ B-O -tissue NOUN B-O -damage NOUN B-O -in ADP B-O -different ADJ B-O -models NOUN B-O -[ PUNCT B-O -4–7 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -false ADJ B-LF -discovery NOUN I-LF -rate NOUN I-LF -( PUNCT B-O -FDR PROPN B-AC -) PUNCT B-O -was AUX B-O -controlled VERB B-O -by ADP B-O -adjusting VERB B-O -the DET B-O -p NOUN B-O -value NOUN B-O -using VERB B-O -the DET B-O -Benjamini PROPN B-O -- PUNCT B-O -Hochberg PROPN B-O -algorithm NOUN B-O -. PUNCT B-O - -We PRON B-O -used VERB B-O -the DET B-O -three NUM B-O -Ethiopian ADJ B-LF -demographic ADJ I-LF -and CCONJ I-LF -health NOUN I-LF -surveys NOUN I-LF -( PUNCT B-O -EDHSs PROPN B-AC -) PUNCT B-O -( PUNCT B-O -2005 NUM B-O -, PUNCT B-O -2011 NUM B-O -, PUNCT B-O -and CCONJ B-O -2016 NUM B-O -) PUNCT B-O -data NOUN B-O -, PUNCT B-O -which PRON B-O -are AUX B-O -the DET B-O -nationally ADV B-O -representative ADJ B-O -surveys NOUN B-O -performed VERB B-O -in ADP B-O -Ethiopia PROPN B-O -. PUNCT B-O - -Acquiring VERB B-O -and CCONJ B-O -sharing VERB B-O -large ADJ B-O -amounts NOUN B-O -of ADP B-O -neuroimaging NOUN B-O -data NOUN B-O -have AUX B-O -recently ADV B-O -become VERB B-O -critical ADJ B-O -for ADP B-O -bridging VERB B-O -the DET B-O -gap NOUN B-O -between ADP B-O -basic ADJ B-O -neuroscience NOUN B-O -research NOUN B-O -and CCONJ B-O -clinical ADJ B-O -applications NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -the DET B-O -diagnosis NOUN B-O -and CCONJ B-O -treatment NOUN B-O -of ADP B-O -psychiatric ADJ B-O -disorders NOUN B-O -( PUNCT B-O -Human PROPN B-LF -Connectome PROPN I-LF -Project PROPN I-LF -[ PUNCT B-O -HCP PROPN B-AC -] PUNCT B-O -[ PUNCT B-O -1 X B-O -] PUNCT B-O -[ PUNCT B-O -http://www.humanconnectomeproject.org/ X B-O -] PUNCT B-O -; PUNCT B-O -Human PROPN B-O -Brain PROPN B-O -Project PROPN B-O -[ PUNCT B-O -https://www.humanbrainproject.eu/en/ X B-O -] PUNCT B-O -; PUNCT B-O -UK PROPN B-O -Biobank PROPN B-O -[ PUNCT B-O -http://www.ukbiobank.ac.uk/ X B-O -] PUNCT B-O -; PUNCT B-O -and CCONJ B-O -Strategic PROPN B-LF -Research PROPN I-LF -Program PROPN I-LF -for ADP I-LF -Brain PROPN I-LF -Sciences PROPN I-LF -[ PUNCT B-O -SRPBS PROPN B-AC -] PUNCT B-O -[ PUNCT B-O -2 X B-O -] PUNCT B-O -[ PUNCT B-O -https://bicr.atr.jp/decnefpro/ X B-O -] PUNCT B-O -) PUNCT B-O -[ PUNCT B-O -3–5 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Analysis NOUN B-O -of ADP B-O -the DET B-O -molecular ADJ B-LF -dynamics NOUN I-LF -( PUNCT B-O -MD PROPN B-AC -) PUNCT B-O -trajectories NOUN B-O -and CCONJ B-O -binding VERB B-O -free ADJ B-O -energy NOUN B-O -components NOUN B-O -shed VERB B-O -light NOUN B-O -into ADP B-O -understanding VERB B-O -the DET B-O -mechanism NOUN B-O -of ADP B-O -the DET B-O -binding VERB B-O -specificity NOUN B-O -of ADP B-O -the DET B-O -Abl PROPN B-O -SH3 PROPN B-AC -domain NOUN B-O -. PUNCT B-O - -HCVcc PROPN B-AC -was AUX B-O -produced VERB B-O -and CCONJ B-O -50 NUM B-LF -% NOUN I-LF -tissue NOUN I-LF -culture NOUN I-LF -infective ADJ I-LF -dose NOUN I-LF -( PUNCT B-O -TCID50 PROPN B-AC -) PUNCT B-O -determined VERB B-O -as SCONJ B-O -described VERB B-O -[ PUNCT B-O -37 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -are AUX B-O -presented VERB B-O -with ADP B-O -counts NOUN B-O -unless SCONJ B-O -otherwise ADV B-O -stated VERB B-O -. PUNCT B-O - -95%CI PROPN B-AC -: PUNCT B-O -95 NUM B-LF -% NOUN I-LF -confidence NOUN I-LF -interval NOUN I-LF -; PUNCT B-O -BSI PROPN B-AC -: PUNCT B-O -Bronchiectasis PROPN B-LF -Severity PROPN I-LF -Index PROPN I-LF -. PUNCT B-O - -To PART B-O -separate VERB B-O -the DET B-O -active ADJ B-O -compounds NOUN B-O -, PUNCT B-O -preparative ADJ B-LF -high ADJ I-LF -performance NOUN I-LF -liquid NOUN I-LF -chromatography NOUN I-LF -( PUNCT B-O -PHPLC PROPN B-AC -) PUNCT B-O -was AUX B-O -conducted VERB B-O -on ADP B-O -a DET B-O -Waters PROPN B-O -2545 NUM B-O -series NOUN B-O -instrument NOUN B-O -( PUNCT B-O -Waters PROPN B-O -, PUNCT B-O -USA PROPN B-O -) PUNCT B-O -equipped VERB B-O -with ADP B-O -a DET B-O -OBD PROPN B-O -- PUNCT B-O -C18 NUM B-O -column NOUN B-O -( PUNCT B-O -19 NUM B-O -mm NOUN B-O -×150 NUM B-O -mm NOUN B-O -, PUNCT B-O -10 NUM B-O -μm NOUN B-O -, PUNCT B-O -Waters PROPN B-O -, PUNCT B-O -USA PROPN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -mobile ADJ B-O -phase NOUN B-O -used VERB B-O -for ADP B-O -PHPLC PROPN B-AC -was AUX B-O -methanol NOUN B-O -/ SYM B-O -H2O NOUN B-O -( PUNCT B-O -1:4 NOUN B-O -, PUNCT B-O -v NOUN B-O -/ SYM B-O -v NOUN B-O -) PUNCT B-O -, PUNCT B-O -applied VERB B-O -with ADP B-O -a DET B-O -flow NOUN B-O -rate NOUN B-O -of ADP B-O -8 NUM B-O -mL NOUN B-O -/ SYM B-O -min NOUN B-O -, PUNCT B-O -and CCONJ B-O -ultraviolet ADJ B-O -detection NOUN B-O -was AUX B-O -a DET B-O -210 NUM B-O -nm NOUN B-O -. PUNCT B-O - -Enhanced VERB B-O -mean ADJ B-O -intensity NOUN B-O -images NOUN B-O -are AUX B-O -shown VERB B-O -to ADP B-O -demonstrate VERB B-O -the DET B-O -alignment NOUN B-O -procedure NOUN B-O -between ADP B-O -a DET B-O -recording NOUN B-O -in ADP B-O -Iso PROPN B-AC -( PUNCT B-O -A NOUN B-O -) PUNCT B-O -and CCONJ B-O -one NUM B-O -during ADP B-O -wakefulness NOUN B-O -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -. PUNCT B-O - -( PUNCT B-O -C NOUN B-O -) PUNCT B-O -Mean ADJ B-O -intensity NOUN B-O -image NOUN B-O -of ADP B-O -the DET B-O -awake ADJ B-O -recording NOUN B-O -aligned VERB B-O -to ADP B-O -the DET B-O -anesthesia NOUN B-O -condition NOUN B-O -. PUNCT B-O - -( PUNCT B-O -D NOUN B-O -) PUNCT B-O -Overlaid VERB B-O -, PUNCT B-O -enhanced VERB B-O -mean ADJ B-O -intensity NOUN B-O -images NOUN B-O -before ADP B-O -and CCONJ B-O -after SCONJ B-O -( PUNCT B-O -E NOUN B-O -) PUNCT B-O -the DET B-O -alignment NOUN B-O -algorithm NOUN B-O -was AUX B-O -applied VERB B-O -. PUNCT B-O - -( PUNCT B-O -F NOUN B-O -) PUNCT B-O -ROIs PROPN B-AC -of ADP B-O -active ADJ B-O -neurons NOUN B-O -during ADP B-O -wakefulness NOUN B-O -( PUNCT B-O -pink NOUN B-O -) PUNCT B-O -, PUNCT B-O -Iso PROPN B-AC -anesthesia NOUN B-O -( PUNCT B-O -cyan NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -their PRON B-O -overlap NOUN B-O -( PUNCT B-O -black NOUN B-O -) PUNCT B-O -. PUNCT B-O - -( PUNCT B-O -G NOUN B-O -– PUNCT B-O -I NOUN B-O -) PUNCT B-O -Magnified VERB B-O -views NOUN B-O -of ADP B-O -a DET B-O -randomly ADV B-O -selected VERB B-O -sections NOUN B-O -from ADP B-O -panels NOUN B-O -( PUNCT B-O -D)–(F NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Iso PROPN B-AC -, PUNCT B-O -isoflurane NOUN B-LF -; PUNCT B-O -ROI PROPN B-AC -, PUNCT B-O -region NOUN B-LF -of ADP I-LF -interest NOUN I-LF -. PUNCT B-O - -For ADP B-O -example NOUN B-O -, PUNCT B-O -the DET B-O -depletion NOUN B-O -of ADP B-O -CpG NOUN B-O -dinucleotides NOUN B-O -in ADP B-O -vertebrate NOUN B-O -- PUNCT B-O -infecting VERB B-O -RNA NOUN B-O -virus NOUN B-O -genomes NOUN B-O -may AUX B-O -have AUX B-O -arisen VERB B-O -to PART B-O -evade VERB B-O -zinc NOUN B-LF -- PUNCT I-LF -finger NOUN I-LF -antiviral ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -ZAP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -an DET B-O -interferon NOUN B-LF -- PUNCT I-LF -stimulated VERB I-LF -gene NOUN I-LF -( PUNCT B-O -ISG PROPN B-AC -) PUNCT B-O -that PRON B-O -initiates VERB B-O -the DET B-O -degradation NOUN B-O -of ADP B-O -CpG NOUN B-O -- PUNCT B-O -rich ADJ B-O -RNA NOUN B-O -molecules NOUN B-O -[ PUNCT B-O -12 NUM B-O -] PUNCT B-O -. PUNCT B-O - -All DET B-O -participants NOUN B-O -in ADP B-O -the DET B-O -training NOUN B-O -program NOUN B-O -were AUX B-O -key ADJ B-O -persons NOUN B-O -, PUNCT B-O -recruited VERB B-O -among ADP B-O -93 NUM B-O -eligible ADJ B-O -baggage NOUN B-O -handlers NOUN B-O -identified VERB B-O -to ADP B-O -have VERB B-O -key ADJ B-O -roles NOUN B-O -in ADP B-O -the DET B-O -company NOUN B-O -( PUNCT B-O -Table NOUN B-O -1 NUM B-O -) PUNCT B-O -, PUNCT B-O -i.e. X B-O -safety NOUN B-LF -officers NOUN I-LF -( PUNCT B-O -SO PROPN B-AC -) PUNCT B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -16 NUM B-O -) PUNCT B-O -, PUNCT B-O -instructors NOUN B-O -teaching VERB B-O -the DET B-O -use NOUN B-O -of ADP B-O -technical ADJ B-O -devices NOUN B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -26 NUM B-O -) PUNCT B-O -, PUNCT B-O -coordinators NOUN B-O -allocating VERB B-O -tasks NOUN B-O -to ADP B-O -baggage NOUN B-O -handlers NOUN B-O -during ADP B-O -the DET B-O -shift NOUN B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -42 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -managers NOUN B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -9 NUM B-O -) PUNCT B-O -. PUNCT B-O - -ChIP PROPN B-O -, PUNCT B-O -chromatin NOUN B-O -immunoprecipitation NOUN B-O -; PUNCT B-O -CREB PROPN B-AC -, PUNCT B-O -cAMP NOUN B-LF -responsive ADJ I-LF -element NOUN I-LF -binding VERB I-LF -protein NOUN I-LF -; PUNCT B-O -DHS PROPN B-AC -, PUNCT B-O -DNase NOUN B-LF -hypersensitive ADJ I-LF -site NOUN I-LF -; PUNCT B-O -FDR PROPN B-AC -, PUNCT B-O -false ADJ B-LF -discovery NOUN I-LF -rate NOUN I-LF -; PUNCT B-O -FOXO1 PROPN B-AC -, PUNCT B-O -Forkhead PROPN B-LF -box NOUN I-LF -O1 NOUN I-LF -; PUNCT B-O -GR PROPN B-AC -, PUNCT B-O -glucocorticoid NOUN B-LF -receptor NOUN I-LF -; PUNCT B-O -H3K27Ac PROPN B-O -, PUNCT B-O -Histone NOUN B-O -3 NUM B-O -lysine NOUN B-O -27 NUM B-O -acetylation NOUN B-O -; PUNCT B-O -ROC PROPN B-AC -, PUNCT B-O -receiver NOUN B-LF -operating NOUN I-LF -characteristic NOUN I-LF -; PUNCT B-O -TSS PROPN B-AC -, PUNCT B-O -transcription NOUN B-LF -start NOUN I-LF -site NOUN I-LF -. PUNCT B-O - -In ADP B-O -the DET B-O -Mexican ADJ B-O -cohort NOUN B-O -, PUNCT B-O -the DET B-O -fibrotic ADJ B-O -non ADJ B-O -- NOUN B-O -IPF PROPN B-AC -group NOUN B-O -consisted VERB B-O -of ADP B-O -patients NOUN B-O -with ADP B-O -Rheumatoid PROPN B-LF -Arthritis PROPN I-LF -interstitial ADJ B-LF -lung NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -RA PROPN B-AC --ILD PROPN B-AC -n NOUN B-O -= SYM B-O -18 NUM B-O -) PUNCT B-O -, PUNCT B-O -Sjögren PROPN B-O -Syndrome PROPN B-O -interstitial ADJ B-LF -lung NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -SS NOUN B-O -- NOUN B-O -ILD PROPN B-AC -n NOUN B-O -= SYM B-O -5 NUM B-O -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -chronic ADJ B-LF -hypersensitivity ADJ I-LF -pneumonitis NOUN I-LF -( PUNCT B-O -cHP PROPN B-AC -n NOUN B-O -= SYM B-O -46 NUM B-O -) PUNCT B-O -. PUNCT B-O - -BChl PROPN B-AC -, PUNCT B-O -bacteriochlorophyll NOUN B-LF -; PUNCT B-O -CD PROPN B-AC -, PUNCT B-O -circular ADJ B-LF -dichroism NOUN I-LF -; PUNCT B-O -LD PROPN B-AC -, PUNCT B-O -linear ADJ B-LF -dichroism NOUN I-LF -; PUNCT B-O -LH1 PROPN B-AC -, PUNCT B-O -light NOUN B-LF -- PUNCT I-LF -harvesting NOUN I-LF -complex NOUN I-LF -1 NUM I-LF -; PUNCT B-O -mdeg NOUN B-O -, PUNCT B-O -millidegree NOUN B-O -; PUNCT B-O -NIR PROPN B-AC -, PUNCT B-O -near ADJ B-LF -infrared ADJ I-LF -region NOUN I-LF -; PUNCT B-O -rel NOUN B-O -. PUNCT B-O - -u. PROPN B-O -, PUNCT B-O -relative ADJ B-O -units NOUN B-O -. PUNCT B-O - -MPoRT PROPN B-AC -parameters NOUN B-O -, PUNCT B-O -including VERB B-O -variable ADJ B-O -description NOUN B-O -, PUNCT B-O -derivation NOUN B-O -and CCONJ B-O -calibration NOUN B-O -are AUX B-O -available ADJ B-O -as ADP B-O -Predictive PROPN B-LF -Modelling PROPN I-LF -Markup PROPN I-LF -Language NOUN I-LF -( PUNCT B-O -PMML PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Lime PROPN B-O -questionnaire NOUN B-O -files NOUN B-O -( PUNCT B-O -See VERB B-O -: PUNCT B-O -S2 PROPN B-O -Text PROPN B-O -, PUNCT B-O -S3 PROPN B-O -Text PROPN B-O -, PUNCT B-O -https://github.com/Ottawa-mHealth/predictive-algorithms X B-O -) PUNCT B-O -[ PUNCT B-O -41,42 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -components NOUN B-O -related VERB B-O -to ADP B-O -blood NOUN B-LF -pressure NOUN I-LF -and CCONJ B-O -the DET B-O -metabolism NOUN B-O -of ADP B-O -glucose NOUN B-O -— PUNCT B-O -high ADJ B-O -- PUNCT B-O -normal ADJ B-O -BP PROPN B-AC -, PUNCT B-O -DM2 PROPN B-AC -, PUNCT B-O -hypertension NOUN B-O -and CCONJ B-O -impaired ADJ B-O -fasting VERB B-O -glucose NOUN B-O -— PUNCT B-O -were AUX B-O -, PUNCT B-O -in ADP B-O -this DET B-O -order NOUN B-O -, PUNCT B-O -those PRON B-O -that PRON B-O -, PUNCT B-O -when SCONJ B-O -they PRON B-O -appear VERB B-O -first ADV B-O -, PUNCT B-O -determine VERB B-O -having VERB B-O -a DET B-O -first ADV B-O -episode NOUN B-O -of ADP B-O -MS PROPN B-AC -, PUNCT B-O -whereas SCONJ B-O -the DET B-O -components NOUN B-O -related VERB B-O -to ADP B-O -dyslipidaemia NOUN B-O -were AUX B-O -associated VERB B-O -with ADP B-O -a DET B-O -lower ADJ B-O -risk NOUN B-O -when SCONJ B-O -they PRON B-O -appear VERB B-O -first ADV B-O -. PUNCT B-O - -SIS PROPN B-AC -- PUNCT B-O -ECM PROPN B-AC -; PUNCT B-O -Small ADJ B-LF -intestinal ADJ I-LF -submucosa NOUN I-LF -- PUNCT B-O -extra ADJ B-LF -cellular ADJ I-LF -matrix NOUN I-LF -, PUNCT B-O -TE PROPN B-AC -; PUNCT B-O -Tissue NOUN B-LF -engineering NOUN I-LF -. PUNCT B-O - -Among ADP B-O -women NOUN B-O -, PUNCT B-O -food NOUN B-O -insufficiency NOUN B-O -was AUX B-O -associated VERB B-O -with ADP B-O -approximately ADV B-O -70 NUM B-O -% NOUN B-O -higher ADJ B-O -odds NOUN B-O -of ADP B-O -inconsistent ADJ B-O -condom NOUN B-O -use NOUN B-O -with ADP B-O -a DET B-O -nonprimary ADJ B-O -partner NOUN B-O -after ADP B-O -adjusting VERB B-O -for ADP B-O -other ADJ B-O -covariates NOUN B-O -in ADP B-O -a DET B-O -multivariate ADJ B-O -model NOUN B-O -( PUNCT B-O -adjusted VERB B-LF -odds NOUN I-LF -ratio NOUN I-LF -[ X B-O -AOR PROPN B-AC -] X B-O -1.73 NUM B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval NOUN I-LF -[ X B-O -CI PROPN B-AC -] X B-O -1.27–2.36 NUM B-O -) PUNCT B-O -( PUNCT B-O -Table PROPN B-O -2 NUM B-O -) PUNCT B-O -. PUNCT B-O - -ASA PROPN B-AC -, PUNCT B-O -American PROPN B-LF -Society PROPN I-LF -of ADP I-LF -Anaesthesiologists PROPN I-LF -; PUNCT B-O -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -OKS PROPN B-AC -, PUNCT B-O -Oxford PROPN B-LF -Knee PROPN I-LF -Score PROPN I-LF -; PUNCT B-O -TKR PROPN B-AC -, PUNCT B-O -total ADJ B-LF -knee NOUN I-LF -replacement NOUN I-LF -. PUNCT B-O - -Manuscript NOUN B-O -, PUNCT B-O -page NOUN B-O -5 NUM B-O -, PUNCT B-O -line NOUN B-O -70 NUM B-O -- PUNCT B-O -76 NUM B-O -: PUNCT B-O -In ADP B-O -our PRON B-O -previous ADJ B-O -work NOUN B-O -, PUNCT B-O -we PRON B-O -integrated VERB B-O -EBV NOUN B-LF -- PUNCT I-LF -EBV PROPN B-AC -encoded VERB I-LF -small ADJ I-LF -RNA NOUN I-LF -in ADP I-LF -situ NOUN I-LF -hybridization NOUN I-LF -( PUNCT B-O -EBER PROPN B-AC -) PUNCT B-O -, PUNCT B-O -immunohistochemistry NOUN B-O -of ADP B-O -DNA NOUN B-O -mismatch NOUN B-O -proteins NOUN B-O -( PUNCT B-O --ISHMMR PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Lauren NOUN B-O -histotyping NOUN B-O -to ADP B-O -design VERB B-O -a DET B-O -practical ADJ B-O --IHCGC PROPN B-AC -subtyping NOUN B-O -algorithm NOUN B-O -, PUNCT B-O -parallel ADJ B-O -to ADP B-O -the DET B-O -TCGA PROPN B-AC -classification NOUN B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -2002–2016 NUM B-O -Nationwide PROPN B-LF -Inpatient PROPN I-LF -Sample PROPN I-LF -( PUNCT B-O -NIS PROPN B-AC -) PUNCT B-O -was AUX B-O -analyzed VERB B-O -. PUNCT B-O - -Here ADV B-O -, PUNCT B-O -we PRON B-O -have AUX B-O -performed VERB B-O -flat ADJ B-O -panel NOUN B-O -- PUNCT B-O -based VERB B-O -volume NOUN B-O -computed VERB B-O -tomography NOUN B-O -( PUNCT B-O -fpVCT PROPN B-AC -) PUNCT B-O -for ADP B-O -rapid ADJ B-O -high ADJ B-O -- PUNCT B-O -resolution NOUN B-O -imaging NOUN B-O -of ADP B-O -bone NOUN B-O -structures NOUN B-O -in ADP B-O -combination NOUN B-O -with ADP B-O -artificial ADJ B-LF -neuronal ADJ I-LF -networks NOUN I-LF -( PUNCT B-O -ANNs PROPN B-AC -) PUNCT B-O -that PRON B-O -are AUX B-O -complex ADJ B-O -nonlinear ADJ B-O -computational ADJ B-O -models NOUN B-O -, PUNCT B-O -designed VERB B-O -much ADV B-O -like ADP B-O -the DET B-O -neuronal ADJ B-O -organization NOUN B-O -of ADP B-O -a DET B-O -brain NOUN B-O -[ X B-O -10–15 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Physical ADJ B-O -exercise NOUN B-O -has VERB B-O -a DET B-O -neuromodulatory ADJ B-O -effect NOUN B-O -on ADP B-O -the DET B-O -central ADJ B-LF -nervous ADJ I-LF -system NOUN I-LF -( PUNCT B-O -CNS PROPN B-AC -) PUNCT B-O -partially ADV B-O -by ADP B-O -modifying VERB B-O -expression NOUN B-O -of ADP B-O -neuropeptides NOUN B-O -produced VERB B-O -and CCONJ B-O -secreted VERB B-O -by ADP B-O -neurons NOUN B-O -and CCONJ B-O -glial ADJ B-O -cells NOUN B-O -, PUNCT B-O -among ADP B-O -which PRON B-O -the DET B-O -best ADV B-O -examined VERB B-O -are AUX B-O -brain NOUN B-LF -- PUNCT I-LF -derived VERB I-LF -neurotrophic ADJ I-LF -factor NOUN I-LF -( PUNCT B-O -BDNF PROPN B-AC -) PUNCT B-O -and CCONJ B-O -glial ADJ B-LF -cell NOUN I-LF -line NOUN I-LF -- PUNCT I-LF -derived VERB I-LF -neurotrophic ADJ I-LF -factor NOUN I-LF -( PUNCT B-O -GDNF PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Because SCONJ B-O -both DET B-O -neurotrophins NOUN B-O -can AUX B-O -cross VERB B-O -the DET B-O -brain NOUN B-O -- PUNCT B-O -blood NOUN B-O -barrier NOUN B-O -( PUNCT B-O -BBB PROPN B-AC -) PUNCT B-O -, PUNCT B-O -their PRON B-O -blood NOUN B-O -levels NOUN B-O -indirectly ADV B-O -reflect VERB B-O -their PRON B-O -production NOUN B-O -in ADP B-O -the DET B-O -CNS PROPN B-AC -. PUNCT B-O - -Moreover ADV B-O -, PUNCT B-O -both DET B-O -neuropeptides NOUN B-O -are AUX B-O -involved VERB B-O -in ADP B-O -modulation NOUN B-O -of ADP B-O -dopaminergic ADJ B-O -and CCONJ B-O -serotoninergic ADJ B-O -system NOUN B-O -function NOUN B-O -. PUNCT B-O - -Trypsin NOUN B-O -- PUNCT B-O -EDTA PROPN B-O -( PUNCT B-O -0.05 NUM B-O -% NOUN B-O -) PUNCT B-O -was AUX B-O -prepared VERB B-O -by ADP B-O -diluting VERB B-O -trypsin NOUN B-O -- PUNCT B-O -EDTA PROPN B-O -( PUNCT B-O -0.5 NUM B-O -% NOUN B-O -) PUNCT B-O -in ADP B-O -phosphate NOUN B-LF -- PUNCT I-LF -buffered VERB I-LF -saline NOUN I-LF -( PUNCT B-O -PBS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -All DET B-O -cell NOUN B-O -culture NOUN B-O -materials NOUN B-O -were AUX B-O -obtained VERB B-O -from ADP B-O -Gibco PROPN B-O -( PUNCT B-O -Life PROPN B-O -Technologies PROPN B-O -, PUNCT B-O -Breda PROPN B-O -, PUNCT B-O -The DET B-O -Netherlands PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Despite SCONJ B-O -the DET B-O -significance NOUN B-O -of ADP B-O -insertions NOUN B-LF -and CCONJ I-LF -deletions NOUN I-LF -( PUNCT B-O -indels PROPN B-AC -) PUNCT B-O -for ADP B-O -human ADJ B-O -genetic ADJ B-O -disease NOUN B-O -[ PUNCT B-O -1 X B-O -] PUNCT B-O -and CCONJ B-O -genome NOUN B-O -evolution NOUN B-O -[ PUNCT B-O -2–5 NUM B-O -] PUNCT B-O -, PUNCT B-O -the DET B-O -mechanisms NOUN B-O -of ADP B-O -their PRON B-O -mutagenesis NOUN B-O -are AUX B-O -not PART B-O -completely ADV B-O -understood VERB B-O -. PUNCT B-O - -Further ADJ B-O -kinetic ADJ B-O -studies NOUN B-O -allow VERB B-O -the DET B-O -first ADJ B-O -snapshot NOUN B-O -on ADP B-O -how SCONJ B-O -silver NOUN B-LF -kills VERB B-O -E. PROPN B-O -coli NOUN B-O -to PART B-O -be AUX B-O -captured VERB B-O -at ADP B-O -the DET B-O -molecular ADJ B-O -level NOUN B-O -( PUNCT B-O -Fig PROPN B-O -4C NUM B-O -) PUNCT B-O -. PUNCT B-O - -Ag+ PROPN B-AC -, PUNCT B-O -once ADV B-O -uptaken VERB B-O -inside ADP B-O -E. PROPN B-O -coli NOUN B-O -cell NOUN B-O -, PUNCT B-O -primarily ADV B-O -targets VERB B-O -glycolysis NOUN B-O -and CCONJ B-O -the DET B-O -oxidative ADJ B-O -branch NOUN B-O -of ADP B-O -the DET B-O -TCA PROPN B-AC -cycle NOUN B-O -( PUNCT B-O -or CCONJ B-O -pyruvate NOUN B-O -cycle NOUN B-O -) PUNCT B-O -via ADP B-O -functional ADJ B-O -disruption NOUN B-O -of ADP B-O -the DET B-O -key ADJ B-O -enzymes NOUN B-O -, PUNCT B-O -followed VERB B-O -by ADP B-O -adaptive ADJ B-O -glyoxylate NOUN B-O -cycle NOUN B-O -, PUNCT B-O -and CCONJ B-O -then ADV B-O -abolishes VERB B-O -bacterial ADJ B-O -oxidative ADJ B-O -defense NOUN B-O -capability NOUN B-O -through ADP B-O -binding NOUN B-O -and CCONJ B-O -inactivation NOUN B-O -of ADP B-O -key ADJ B-O -antioxidant ADJ B-O -enzymes NOUN B-O -. PUNCT B-O - -Second X B-O -, PUNCT B-O -we PRON B-O -defined VERB B-O -people NOUN B-O -receiving VERB B-O -long ADJ B-O -- PUNCT B-O -term NOUN B-O -opioid NOUN B-LF -pain NOUN I-LF -therapy NOUN I-LF -( PUNCT B-O -OPT PROPN B-AC -) PUNCT B-O -as ADP B-O -those PRON B-O -who PRON B-O -had VERB B-O -90 NUM B-O -unique ADJ B-O -days NOUN B-O -of ADP B-O -therapy NOUN B-O -with ADP B-O -opioids NOUN B-O -indicated VERB B-O -to ADP B-O -treat VERB B-O -pain NOUN B-O -in ADP B-O -the DET B-O -100 NUM B-O -days NOUN B-O -prior ADV B-O -to ADP B-O -or CCONJ B-O -including VERB B-O -enrolment NOUN B-O -termination NOUN B-O -. PUNCT B-O - -Despite SCONJ B-O -more ADJ B-O -than ADP B-O -two NUM B-O -decades NOUN B-O -of ADP B-O -research NOUN B-O -on ADP B-O -adherence NOUN B-O -to ADP B-O -antiretroviral ADJ B-LF -therapy NOUN I-LF -( PUNCT B-O -ART PROPN B-AC -) PUNCT B-O -and CCONJ B-O -more ADJ B-O -than ADP B-O -17 NUM B-O -million NUM B-O -HIV PROPN B-O -- PUNCT B-O -positive ADJ B-O -individuals NOUN B-O -on ADP B-O -treatment NOUN B-O -, PUNCT B-O -adherence NOUN B-O -to ADP B-O -ART PROPN B-AC -remains VERB B-O -a DET B-O -major ADJ B-O -challenge NOUN B-O -. PUNCT B-O - -To PART B-O -further ADV B-O -evaluate VERB B-O -the DET B-O -inhibitory ADJ B-O -effects NOUN B-O -of ADP B-O -these DET B-O -two NUM B-O -compounds NOUN B-O -on ADP B-O -bacterial ADJ B-O -growth NOUN B-O -, PUNCT B-O -the DET B-O -compounds NOUN B-O -were AUX B-O -supplemented VERB B-O -into ADP B-O -the DET B-O -culture NOUN B-O -medium NOUN B-O -of ADP B-O -H. NOUN B-O -pylori PROPN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -pH NOUN B-O -of ADP B-O -brucella NOUN B-O -broth NOUN B-O -medium NOUN B-O -was AUX B-O -then ADV B-O -adjusted VERB B-O -to ADP B-O -5.0 NUM B-O -with ADP B-O -sterile ADJ B-O -dilute ADJ B-O -hydrochloric ADJ B-LF -acid NOUN I-LF -( PUNCT B-O -HCl PROPN B-AC -) PUNCT B-O -; PUNCT B-O -inoculum NOUN B-O -was AUX B-O -added VERB B-O -to ADP B-O -an DET B-O -initial ADJ B-O -optical ADJ B-O -density NOUN B-O -at ADP B-O -600 NUM B-O -nm NOUN B-O -( PUNCT B-O -OD600 NUM B-O -) PUNCT B-O -of ADP B-O -ca X B-O -. PUNCT B-O - -0.1 NUM B-O -. PUNCT B-O - -The DET B-O -authors NOUN B-O -, PUNCT B-O -in ADP B-O -a DET B-O -previous ADJ B-O -article NOUN B-O -“ PUNCT B-O -Recommendation NOUN B-O -for ADP B-O -ISTH PROPN B-O -/ SYM B-O -SSC PROPN B-O -Criterion NOUN B-O -2015 NUM B-O -for ADP B-O -autoimmune ADJ B-LF -acquired VERB I-LF -factor NOUN I-LF -XIII/13 NUM I-LF -deficiency NOUN I-LF -” PUNCT B-O -( PUNCT B-O -Thromb PROPN B-O -Haemost PROPN B-O -2016 NUM B-O -; PUNCT B-O -116:772 NUM B-O -- NUM B-O -774 NUM B-O -) PUNCT B-O -refer VERB B-O -to ADP B-O -this DET B-O -deficiency NOUN B-O -as ADP B-O -AAXIII/13D PROPN B-AC -instead ADV B-O -of ADP B-O -AiF13D. NOUN B-O -Children NOUN B-O -were AUX B-O -defined VERB B-O -as ADP B-O -being AUX B-O -lost VERB B-LF -to PART I-LF -follow NOUN I-LF -- PUNCT I-LF -up ADP I-LF -( PUNCT B-O -LTFU PROPN B-AC -) PUNCT B-O -and CCONJ B-O -were AUX B-O -censored VERB B-O -if SCONJ B-O -they PRON B-O -had VERB B-O -no DET B-O -contact NOUN B-O -with ADP B-O -their PRON B-O -health NOUN B-O -care NOUN B-O -facility NOUN B-O -for ADP B-O -9 NUM B-O -mo NOUN B-O -before ADP B-O -database NOUN B-O -closure NOUN B-O -( PUNCT B-O -visits NOUN B-O -are AUX B-O -scheduled VERB B-O -up ADP B-O -to PART B-O -6 NUM B-O -mo NOUN B-O -apart ADV B-O -and CCONJ B-O -clinic NOUN B-O -visits NOUN B-O -being AUX B-O -delayed VERB B-O -for ADP B-O -up ADP B-O -to PART B-O -3 NUM B-O -mo NOUN B-O -are AUX B-O -possible ADJ B-O -) PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -DDD PROPN B-AC -, PUNCT B-O -defined VERB B-LF -daily ADJ I-LF -dose NOUN I-LF -. PUNCT B-O - -NP PROPN B-AC -, PUNCT B-O -normal ADJ B-LF -pregnancy NOUN I-LF -group NOUN B-O -. PUNCT B-O - -Furthermore ADV B-O -, PUNCT B-O -observational ADJ B-O -studies NOUN B-O -of ADP B-O -ITN PROPN B-AC -use NOUN B-O -have AUX B-O -consistently ADV B-O -shown VERB B-O -findings NOUN B-O -similar ADJ B-O -to ADP B-O -those PRON B-O -of ADP B-O -randomized VERB B-LF -controlled VERB I-LF -trials NOUN I-LF -( PUNCT B-O -RCTs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -suggesting VERB B-O -that SCONJ B-O -within ADP B-O -specific ADJ B-O -communities NOUN B-O -confounding VERB B-O -is AUX B-O -not PART B-O -pronounced VERB B-O -[ PUNCT B-O -29 NUM B-O -] PUNCT B-O -. PUNCT B-O - -On ADP B-O -the DET B-O -other ADJ B-O -hand NOUN B-O -, PUNCT B-O -5-HT PROPN B-AC -concentration NOUN B-O -was AUX B-O -significantly ADV B-O -decreased VERB B-O -in ADP B-O -the DET B-O -platelets NOUN B-O -in ADP B-O -patients NOUN B-O -with ADP B-O -AD PROPN B-AC -[ X B-O -54 X B-O -] PUNCT B-O -and CCONJ B-O -selective ADJ B-O -serotonin NOUN B-LF -reuptake NOUN B-O -inhibitors NOUN B-O -improve VERB B-O -decreased VERB B-O -cognitive ADJ B-O -performance NOUN B-O -and CCONJ B-O -BPSD PROPN B-AC -seen VERB B-O -in ADP B-O -patients NOUN B-O -with ADP B-O -AD PROPN B-AC -[ X B-O -55 NUM B-O -, PUNCT B-O -56 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Pre X B-O -= PUNCT B-O -Precision NOUN B-O -score NOUN B-O -, PUNCT B-O -Rec NOUN B-O -= PUNCT B-O -Recall NOUN B-O -score NOUN B-O -, PUNCT B-O -F1 PROPN B-AC -= PUNCT B-O -F1 NOUN B-LF -- PUNCT I-LF -F1 PROPN B-AC -score NOUN I-LF -, PUNCT B-O -AUC PROPN B-AC -= PUNCT B-O -AUC PROPN B-AC -score NOUN B-O -, PUNCT B-O -and CCONJ B-O -A(i NOUN B-O -) PUNCT B-O -= PUNCT B-O -{ PUNCT B-O -Prei NOUN B-O -, PUNCT B-O -Reci PROPN B-O -, PUNCT B-O -F1i X B-O -, PUNCT B-O -AUCi PROPN B-O -} PUNCT B-O -; PUNCT B-O -w(i NOUN B-O -) PUNCT B-O -is AUX B-O -the DET B-O -weight NOUN B-O -generated VERB B-O -for ADP B-O -the DET B-O -ith PROPN B-O -base NOUN B-O -learner NOUN B-O -to PART B-O -compute VERB B-O -the DET B-O -ensemble NOUN B-O -, PUNCT B-O -pj(i NOUN B-O -) PUNCT B-O -is AUX B-O -the DET B-O -probability NOUN B-O -score NOUN B-O -for ADP B-O -the DET B-O -jth ADJ B-O -sample NOUN B-O -by ADP B-O -the DET B-O -ith PROPN B-O -classifier NOUN B-O -, PUNCT B-O -and CCONJ B-O -ensj NOUN B-O -is AUX B-O -the DET B-O -fused VERB B-O -probability NOUN B-O -score NOUN B-O -for ADP B-O -the DET B-O -jth ADJ B-O -sample NOUN B-O -; PUNCT B-O -and CCONJ B-O -the DET B-O -argmax NOUN B-O -function NOUN B-O -returns VERB B-O -the DET B-O -position NOUN B-O -having VERB B-O -the DET B-O -highest ADJ B-O -value NOUN B-O -in ADP B-O -a DET B-O -1D ADJ B-O -array NOUN B-O -, PUNCT B-O -i.e. X B-O -, PUNCT B-O -in ADP B-O -this DET B-O -case NOUN B-O -it PRON B-O -generates VERB B-O -the DET B-O -predicted VERB B-O -class NOUN B-O -of ADP B-O -the DET B-O -sample NOUN B-O -. PUNCT B-O - -This PRON B-O -indicates VERB B-O -that SCONJ B-O -a DET B-O -Chromosome NOUN B-O -4 NUM B-O -bivalent ADJ B-O -experiences VERB B-O -on ADP B-O -average ADJ B-O -1.76 NUM B-O -CO PROPN B-AC -in ADP B-O -male ADJ B-LF -meiosis NOUN B-O -, PUNCT B-O -but CCONJ B-O -only ADV B-O -1.05 NUM B-O -CO PROPN B-AC -in ADP B-O -female ADJ B-LF -meiosis NOUN B-O -( PUNCT B-O -M PROPN B-AC -/ SYM B-O -F PROPN B-AC -ratio NOUN B-O -1.68 NUM B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -results NOUN B-O -in ADP B-O -this DET B-O -section NOUN B-O -were AUX B-O -confirmed VERB B-O -by ADP B-O -NCBI PROPN B-O -’s PART B-O -Conserved PROPN B-LF -Domain PROPN I-LF -Database PROPN I-LF -( PUNCT B-O -CDD PROPN B-AC -) PUNCT B-O -[ X B-O -93 X B-O -] X B-O -matches NOUN B-O -obtained VERB B-O -using VERB B-O -rpsblast PROPN B-O -with ADP B-O -composition NOUN B-O -- PUNCT B-O -based VERB B-O -statistics NOUN B-O -and CCONJ B-O -masking VERB B-O -low ADJ B-O -- PUNCT B-O -information NOUN B-O -regions NOUN B-O -. PUNCT B-O - -A X B-O -range NOUN B-O -of ADP B-O -virulence NOUN B-O -assays NOUN B-O -were AUX B-O -performed VERB B-O -on ADP B-O -a DET B-O -subset NOUN B-O -of ADP B-O -10 NUM B-O -high- ADJ B-O -and CCONJ B-O -10 NUM B-O -low ADJ B-O -- PUNCT B-O -toxicity NOUN B-O -isolates NOUN B-O -from ADP B-O -the DET B-O -USA300 PROPN B-O -collection NOUN B-O -to PART B-O -identify VERB B-O -the DET B-O -biological ADJ B-O -feature NOUN B-O -that PRON B-O -explains VERB B-O -the DET B-O -observed VERB B-O -inverse ADJ B-O -correlation NOUN B-O -between ADP B-O -toxicity NOUN B-O -and CCONJ B-O -disease NOUN B-O -severity NOUN B-O -. PUNCT B-O - -( PUNCT B-O -A X B-O -) PUNCT B-O -The DET B-O -toxicity NOUN B-O -of ADP B-O -the DET B-O -subset NOUN B-O -of ADP B-O -isolates NOUN B-O -is AUX B-O -provided VERB B-O -for ADP B-O -comparison NOUN B-O -. PUNCT B-O - -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -The DET B-O -ability NOUN B-O -of ADP B-O -the DET B-O -bacteria NOUN B-O -to PART B-O -invade VERB B-O -EA.hy926 NOUN B-O -endothelial ADJ B-O -cells NOUN B-O -. PUNCT B-O - -( PUNCT B-O -C X B-O -) PUNCT B-O -The DET B-O -ability NOUN B-O -of ADP B-O -the DET B-O -bacteria NOUN B-O -to PART B-O -induce VERB B-O -the DET B-O -release NOUN B-O -of ADP B-O -neutrophil NOUN B-LF -extracellular ADJ I-LF -traps NOUN I-LF -( PUNCT B-O -NETs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -( PUNCT B-O -D X B-O -) PUNCT B-O -The DET B-O -release NOUN B-O -of ADP B-O -proteases NOUN B-O -by ADP B-O -the DET B-O -bacteria NOUN B-O -. PUNCT B-O - -( PUNCT B-O -E X B-O -) PUNCT B-O -Resistance NOUN B-O -of ADP B-O -the DET B-O -bacteria NOUN B-O -to PART B-O -human ADJ B-O -neutrophil NOUN B-O -defensin-1 NOUN B-O -. PUNCT B-O - -( PUNCT B-O -F X B-O -) PUNCT B-O -The DET B-O -ability NOUN B-O -of ADP B-O -the DET B-O -bacteria NOUN B-O -to PART B-O -form VERB B-O -biofilms NOUN B-O -. PUNCT B-O - -Although SCONJ B-O -the DET B-O -percentage NOUN B-O -of ADP B-O -women NOUN B-O -attending VERB B-O -Focused PROPN B-LF -Antenatal PROPN I-LF -Care PROPN I-LF -( PUNCT B-O -FANC PROPN B-AC -) PUNCT B-O -for ADP B-O -at ADP B-O -least ADV B-O -once ADV B-O -generally ADV B-O -tends VERB B-O -to PART B-O -be AUX B-O -satisfactory ADJ B-O -even ADV B-O -in ADP B-O -low ADJ B-O -- PUNCT B-O -income NOUN B-O -countries NOUN B-O -, PUNCT B-O -maternal ADJ B-O -and CCONJ B-O -neonatal ADJ B-O -mortality NOUN B-O -remain VERB B-O -high ADJ B-O -. PUNCT B-O - -Cycloheximide NOUN B-O -was AUX B-O -added VERB B-O -at ADP B-O -time NOUN B-O -= CCONJ B-O -0 NUM B-O -and CCONJ B-O -the DET B-O -amount NOUN B-O -of ADP B-O -Gal80 NOUN B-O -protein NOUN B-O -remaining VERB B-O -in ADP B-O -the DET B-O -cells NOUN B-O -after ADP B-O -the DET B-O -indicated VERB B-O -number NOUN B-O -of ADP B-O -hours NOUN B-O -was AUX B-O -determined VERB B-O -by ADP B-O -Western ADJ B-O -blot NOUN B-O -with ADP B-O -the DET B-O -help NOUN B-O -of ADP B-O -an DET B-O -anti ADJ B-O -- ADJ B-O -hemagglutinin ADJ B-LF -( PUNCT B-O -HA PROPN B-AC -) PUNCT B-O -antibody NOUN B-O -( PUNCT B-O -upper ADJ B-O -panels NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Dpp PROPN B-AC -, PUNCT B-O -Decapentaplegic PROPN B-LF -; PUNCT B-O -Hh PROPN B-AC -, PUNCT B-O -Hedgehog PROPN B-LF -. PUNCT B-O - -The DET B-O -most ADV B-O -common ADJ B-O -alternative ADJ B-O -infectious ADJ B-LF -disease NOUN I-LF -( PUNCT B-O -ID)—diagnoses PROPN B-AC -were AUX B-O -pneumonia NOUN B-O -( PUNCT B-O -n NOUN B-O -= PUNCT B-O -30 NUM B-O -) PUNCT B-O -, PUNCT B-O -infection NOUN B-O -of ADP B-O -totally ADV B-O -implantable ADJ B-O -venous ADJ B-O -access NOUN B-O -device NOUN B-O -( PUNCT B-O -port NOUN B-O -, PUNCT B-O -n NOUN B-O -= PUNCT B-O -9 NUM B-O -) PUNCT B-O -, PUNCT B-O -skin NOUN B-LF -and CCONJ I-LF -soft ADJ I-LF -tissue NOUN I-LF -infection NOUN I-LF -( PUNCT B-O -SSTI PROPN B-AC -, PUNCT B-O -n NOUN B-O -= PUNCT B-O -9 NUM B-O -) PUNCT B-O -and CCONJ B-O -influenza NOUN B-O -( PUNCT B-O -n NOUN B-O -= PUNCT B-O -4 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Lysates NOUN B-O -derived VERB B-O -from ADP B-O -virions NOUN B-O -containing VERB B-O -HA PROPN B-O -- PUNCT B-O -tagged VERB B-O -A3G PROPN B-AC -were AUX B-O -size NOUN B-O -- PUNCT B-O -fractionated VERB B-O -by ADP B-O -fast ADJ B-LF -protein NOUN I-LF -liquid NOUN I-LF -chromatography NOUN I-LF -( PUNCT B-O -FPLC PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Each DET B-O -fraction NOUN B-O -was AUX B-O -then ADV B-O -analyzed VERB B-O -by ADP B-O -SDS PROPN B-O -- PUNCT B-O -PAGE PROPN B-O -and CCONJ B-O -immunoblotting VERB B-O -with ADP B-O -anti ADJ B-O -- PUNCT B-O -HA PROPN B-O -monoclonal ADJ B-O -antibodies NOUN B-O -( PUNCT B-O -Figure PROPN B-O -3A NUM B-O -) PUNCT B-O -. PUNCT B-O - -Surprisingly ADV B-O -, PUNCT B-O -virion NOUN B-O -- PUNCT B-O -incorporated VERB B-O -HA PROPN B-O -- PUNCT B-O -A3 PROPN B-AC -was AUX B-O -detected VERB B-O -almost ADV B-O -exclusively ADV B-O -in ADP B-O -the DET B-O -GHMM PROPN B-AC -region NOUN B-O -, PUNCT B-O -eluting VERB B-O -in ADP B-O -the DET B-O -void ADJ B-O -volume NOUN B-O -of ADP B-O -the DET B-O -Superose PROPN B-O -6 NUM B-O -column NOUN B-O -( PUNCT B-O -Figure PROPN B-O -3A NUM B-O -) PUNCT B-O -. PUNCT B-O - -This DET B-O -result NOUN B-O -was AUX B-O -not PART B-O -due ADJ B-O -to ADP B-O -incomplete ADJ B-O -lysis NOUN B-O -of ADP B-O -the DET B-O -virion NOUN B-O -cores NOUN B-O -since SCONJ B-O -the DET B-O -p24 NOUN B-O -viral ADJ B-O -capsid NOUN B-LF -( PUNCT B-O -p24 NOUN B-O -- PUNCT B-O -CA PROPN B-AC -) PUNCT B-O -was AUX B-O -detected VERB B-O -only ADV B-O -in ADP B-O -the DET B-O -expected VERB B-O -LMM PROPN B-AC -fractions NOUN B-O -. PUNCT B-O - -Inward ADJ B-LF -rectifier NOUN I-LF -potassium NOUN I-LF -current NOUN I-LF -( PUNCT B-O -IK1 PROPN B-AC -) PUNCT B-O -was AUX B-O -measured VERB B-O -by ADP B-O -determining VERB B-O -the DET B-O -steady ADJ B-O -- PUNCT B-O -state NOUN B-O -current NOUN B-O -at ADP B-O -the DET B-O -end NOUN B-O -of ADP B-O -300 NUM B-O -ms NOUN B-O -long ADJ B-O -pulses NOUN B-O -clamped VERB B-O -to ADP B-O -potentials NOUN B-O -ranging VERB B-O -from ADP B-O --80 NUM B-O -to ADP B-O -0 NUM B-O -mV. NOUN B-O -FFS PROPN B-AC -, PUNCT B-O -Medicare PROPN B-LF -fee NOUN I-LF -- PUNCT I-LF -for ADP I-LF -- PUNCT I-LF -service NOUN I-LF -; PUNCT B-O -IPTW PROPN B-AC -, PUNCT B-O -inverse ADJ B-LF -probability NOUN I-LF -of ADP I-LF -treatment NOUN I-LF -weighting NOUN I-LF -; PUNCT B-O -MA PROPN B-AC -, PUNCT B-O -Medicare PROPN B-LF -Advantage PROPN I-LF -; PUNCT B-O -SNF PROPN B-AC -, PUNCT B-O -skilled ADJ B-LF -nursing NOUN I-LF -facility NOUN I-LF -. PUNCT B-O - -Weak ADJ B-O -CGIs PROPN B-AC -may AUX B-O -be AUX B-O -depleted VERB B-O -because SCONJ B-O -they PRON B-O -are AUX B-O -heavily ADV B-O -methylated VERB B-O -and CCONJ B-O -therefore ADV B-O -not PART B-O -enriched VERB B-O -by ADP B-O -CAP PROPN B-AC -. PUNCT B-O - -Indeed ADV B-O -, PUNCT B-O -22 NUM B-O -methylated VERB B-O -weak ADJ B-O -CpG NOUN B-LF -islands NOUN I-LF -[ X B-O -14 X B-O -] X B-O -were AUX B-O -not PART B-O -detected VERB B-O -in ADP B-O -our PRON B-O -library NOUN B-O -. PUNCT B-O - -Thus ADV B-O -, PUNCT B-O -it PRON B-O -is AUX B-O -necessary ADJ B-O -to PART B-O -test VERB B-O -our PRON B-O -hypothesis NOUN B-O -that SCONJ B-O -the DET B-O -treatment NOUN B-O -of ADP B-O -stroke NOUN B-O -with ADP B-O -BMSC PROPN B-AC -has AUX B-O -therapeutic ADJ B-O -efficacy NOUN B-O -in ADP B-O -the DET B-O -most ADV B-O -common ADJ B-O -form NOUN B-O -of ADP B-O -diabetes NOUN B-O -, PUNCT B-O -type NOUN B-LF -2 NUM I-LF -diabetes NOUN I-LF -mellitus NOUN I-LF -( PUNCT B-O -T2DM PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -T2DM PROPN B-AC -was AUX B-O -induced VERB B-O -in ADP B-O -adult ADJ B-O -male ADJ B-O -Wistar PROPN B-O -rats NOUN B-O -by ADP B-O -administration NOUN B-O -of ADP B-O -a DET B-O -high ADJ B-O -fat NOUN B-O -diet NOUN B-O -in ADP B-O -combination NOUN B-O -with ADP B-O -a DET B-O -single ADJ B-O -intraperitoneal ADJ B-O -injection NOUN B-O -( PUNCT B-O -35mg NUM B-O -/ SYM B-O -kg NOUN B-O -) PUNCT B-O -of ADP B-O -streptozotocin NOUN B-O -. PUNCT B-O - -There PRON B-O -are AUX B-O -eight NUM B-O -mammalian ADJ B-O -IAPs NOUN B-O -. PUNCT B-O - -Some DET B-O -IAPs NOUN B-O -also ADV B-O -contain VERB B-O -a DET B-O -RING NOUN B-O -motif NOUN B-O -that PRON B-O -confers VERB B-O -ubiquitin NOUN B-O -protein NOUN B-O -ligase NOUN B-O -( PUNCT B-O -E3 NOUN B-O -) PUNCT B-O -activity NOUN B-O -. PUNCT B-O - -c NOUN B-O -- PUNCT B-O -IAP1 PROPN B-O -and CCONJ B-O -c NOUN B-O -- PUNCT B-O -IAP2 PROPN B-O -are AUX B-O -such ADJ B-O -RING NOUN B-O -- PUNCT B-O -containing VERB B-O -proteins NOUN B-O -that PRON B-O -bind VERB B-O -caspase-7 NOUN B-O -or CCONJ B-O --9 NUM B-O -but CCONJ B-O -, PUNCT B-O -unlike ADP B-O -XIAP PROPN B-O -, PUNCT B-O -do AUX B-O -not PART B-O -inhibit VERB B-O -their PRON B-O -enzymatic ADJ B-O -activities NOUN B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -c NOUN B-O -- PUNCT B-O -IAP1 PROPN B-O -and CCONJ B-O -c NOUN B-O -- PUNCT B-O -IAP2 PROPN B-O -also ADV B-O -bind VERB B-O -the DET B-O -adaptor NOUN B-O -protein NOUN B-O -TNF PROPN B-LF -Receptor PROPN I-LF -Associated PROPN I-LF -Factor PROPN I-LF -2 NUM I-LF -( PUNCT B-O -TRAF2 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -are AUX B-O -components NOUN B-O -of ADP B-O -the DET B-O -Tumor PROPN B-LF -Necrosis PROPN I-LF -Factor PROPN I-LF -Receptor PROPN I-LF -1 NUM I-LF -( PUNCT B-O -TNF-R1 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -2 NUM B-O -signaling NOUN B-O -complexes NOUN B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Fig NOUN B-O -1A–1C NOUN B-O -shows VERB B-O -that SCONJ B-O -hearts NOUN B-O -exposed VERB B-O -to ADP B-O -40 NUM B-O -minutes NOUN B-O -of ADP B-O -ischemia NOUN B-O -and CCONJ B-O -60 NUM B-O -minutes NOUN B-O -of ADP B-O -reperfusion NOUN B-O -( PUNCT B-O -I/R PROPN B-AC -) PUNCT B-O -suffered VERB B-O -a DET B-O -significant ADJ B-O -decrease NOUN B-O -in ADP B-O -the DET B-O -left ADJ B-LF -ventricular ADJ I-LF -developed VERB I-LF -pressure NOUN I-LF -( PUNCT B-O -LVDP PROPN B-AC -) PUNCT B-O -as ADP B-O -well ADV B-O -as ADP B-O -in ADP B-O -the DET B-O -positive ADJ B-O -and CCONJ B-O -negative ADJ B-O -maximum ADJ B-O -derivative NOUN B-LF -of ADP I-LF -left ADJ I-LF -ventricular ADJ I-LF -pressure NOUN I-LF -( PUNCT B-O -±dP NOUN B-O -) PUNCT B-O -, PUNCT B-O -indicating VERB B-O -significant ADJ B-O -loss NOUN B-O -in ADP B-O -heart NOUN B-O -function NOUN B-O -. PUNCT B-O - -CK-666 PROPN B-AC -, PUNCT B-O -Arp2/3 NOUN B-LF -complex NOUN I-LF -Arp2/3 PROPN B-AC -inhibitor NOUN I-LF -I. NOUN I-LF -Data NOUN B-O -are AUX B-O -shown VERB B-O -as ADP B-O -mean NOUN B-O -± ADJ B-O -SEM NOUN B-O -. PUNCT B-O - -AAV PROPN B-O -, PUNCT B-O -adeno NOUN B-O -- PUNCT B-O -associated VERB B-O -virus NOUN B-O -; PUNCT B-O -ARC PROPN B-AC -, PUNCT B-O -arcuate ADJ B-LF -nucleus NOUN I-LF -of ADP I-LF -the DET I-LF -hypothalamus NOUN I-LF -; PUNCT B-O -cap NOUN B-O -, PUNCT B-O -capsaicin NOUN B-O -; PUNCT B-O -CNO PROPN B-AC -, PUNCT B-O -clozapine NOUN B-LF -- PUNCT I-LF -N NOUN I-LF -- PUNCT I-LF -oxide NOUN I-LF -; PUNCT B-O -Cre PROPN B-AC -, PUNCT B-O -Cre PROPN B-LF -recombinase NOUN I-LF -Cre PROPN B-AC -; PUNCT B-O -DREADD PROPN B-AC -, PUNCT B-O -designer NOUN B-LF -receptor NOUN I-LF -exclusively ADV I-LF -activated VERB I-LF -by ADP I-LF -designer NOUN I-LF -drugs NOUN I-LF -; PUNCT B-O -hSyn PROPN B-AC -, PUNCT B-O -human ADJ B-LF -synapsin NOUN I-LF -I NUM I-LF -promoter NOUN I-LF -; PUNCT B-O -i.p NOUN B-O -. PUNCT B-O - -, PUNCT B-O -Intraperitoneal NOUN B-O -; PUNCT B-O -mCherry PROPN B-AC -, PUNCT B-O -monomeric ADJ B-LF -cherry NOUN I-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -MC3/4 PROPN B-O -, PUNCT B-O -melanocortin NOUN B-O -3/4 NUM B-O -; PUNCT B-O -POMC PROPN B-AC -, PUNCT B-O -proopiomelanocortin NOUN B-LF -; PUNCT B-O -RTX PROPN B-AC -, PUNCT B-O -resiniferatoxin NOUN B-LF -; PUNCT B-O -sal NOUN B-O -, PUNCT B-O -saline NOUN B-O -; PUNCT B-O -TRPV1 PROPN B-AC -, PUNCT B-O -transient ADJ B-LF -receptor NOUN I-LF -potential ADJ I-LF -vanilloid NOUN I-LF -1 NUM I-LF -receptor NOUN I-LF -. PUNCT B-O - -Targeted VERB B-LF -radionuclide NOUN I-LF -therapy NOUN I-LF -( PUNCT B-O -TRNT PROPN B-AC -) PUNCT B-O -with ADP B-O -alpha NOUN B-O -particles NOUN B-O -is AUX B-O -thus ADV B-O -complementary ADJ B-O -to ADP B-O -TRNT PROPN B-AC -with ADP B-O -beta NOUN B-O -particles NOUN B-O -, PUNCT B-O -whose DET B-O -millimetric ADJ B-O -path NOUN B-O -is AUX B-O -better ADV B-O -suited ADJ B-O -to ADP B-O -bulky ADJ B-O -tumour NOUN B-O -treatment NOUN B-O -. PUNCT B-O - -One NUM B-O -part NOUN B-O -is AUX B-O -called VERB B-O -GP PROPN B-AC -( PUNCT B-O -which PRON B-O -stands VERB B-O -for ADP B-O -glycoprotein NOUN B-LF -) PUNCT B-O -and CCONJ B-O -is AUX B-O -from ADP B-O -the DET B-O -outer ADJ B-O -coat NOUN B-O -of ADP B-O -the DET B-O -virus NOUN B-O -; PUNCT B-O -the DET B-O -other ADJ B-O -, PUNCT B-O -NP PROPN B-AC -( PUNCT B-O -nucleoprotein NOUN B-LF -) PUNCT B-O -, PUNCT B-O -is AUX B-O -from ADP B-O -its PRON B-O -inside NOUN B-O -. PUNCT B-O - -Bioreactors NOUN B-O -were AUX B-O -filled VERB B-O -with ADP B-O -different ADJ B-O -mixtures NOUN B-O -of ADP B-O -WAS PROPN B-AC -substrate NOUN B-O -and CCONJ B-O -a DET B-O -co NOUN B-O -- NOUN B-O -substrate NOUN B-O -( PUNCT B-O -FW PROPN B-AC -or CCONJ B-O -GG PROPN B-AC -) PUNCT B-O -prepared VERB B-O -in ADP B-O -different ADJ B-O -proportions NOUN B-O -of ADP B-O -grams NOUN B-O -of ADP B-O -chemical ADJ B-LF -oxygen NOUN I-LF -demand NOUN I-LF -( PUNCT B-O -COD PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -These DET B-O -proportions NOUN B-O -consisted VERB B-O -of ADP B-O -0/100 NUM B-O -, PUNCT B-O -25/75 NUM B-O -, PUNCT B-O -50/50 NUM B-O -, PUNCT B-O -75/25 NUM B-O -, PUNCT B-O -and CCONJ B-O -100/0 NUM B-O -gCOD NOUN B-O -WAS PROPN B-AC -/ SYM B-O -gCOD NOUN B-O -co NOUN B-O -- NOUN B-O -substrate NOUN B-O -. PUNCT B-O - -We PRON B-O -appraised VERB B-O -the DET B-O -certainty NOUN B-O -of ADP B-O -the DET B-O -key ADJ B-O -elements NOUN B-O -according VERB B-O -to ADP B-O -the DET B-O -Grading PROPN B-LF -of ADP I-LF -Recommendations PROPN I-LF -Assessment PROPN I-LF -, PUNCT I-LF -Development PROPN I-LF -and CCONJ I-LF -Evaluation PROPN I-LF -( PUNCT B-O -GRADE PROPN B-AC -) PUNCT B-O -tool NOUN B-O -[ PUNCT B-O -29–31 NUM B-O -] X B-O -( PUNCT B-O -S3 PROPN B-O -Table NOUN B-O -) PUNCT B-O -. PUNCT B-O - -H PROPN B-AC -’s PART B-O -Byproduct NOUN B-LF -B PROPN B-AC -is AUX B-O -required VERB B-O -by ADP B-O -Manufacturer NOUN B-LF -FISH PROPN B-AC -, PUNCT B-O -fluorescence NOUN B-LF -in ADP I-LF -situ ADJ I-LF -hybridization NOUN I-LF -; PUNCT B-O -SIM PROPN B-AC -, PUNCT B-O -structured ADJ B-LF -illumination NOUN I-LF -microscopy NOUN I-LF -; PUNCT B-O -WT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -type NOUN I-LF -. PUNCT B-O - -AMP NOUN B-LF -- PUNCT I-LF -activated VERB I-LF -protein NOUN I-LF -kinase NOUN I-LF -( PUNCT B-O -AMPK PROPN B-AC -) PUNCT B-O -is AUX B-O -an DET B-O -evolutionarily ADV B-O -- PUNCT B-O -conserved VERB B-O -fuel NOUN B-O -- PUNCT B-O -sensitive ADJ B-O -serine NOUN B-O -/ SYM B-O -threonine NOUN B-O -protein NOUN B-O -kinase NOUN B-O -and CCONJ B-O -cellular ADJ B-O -nutrient NOUN B-O -sensor NOUN B-O -implicated VERB B-O -in ADP B-O -the DET B-O -regulation NOUN B-O -of ADP B-O -energy NOUN B-O -homeostasis NOUN B-O -[ PUNCT B-O -19 X B-O -] PUNCT B-O -[ PUNCT B-O -20 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Such ADJ B-O -measurement NOUN B-O -results VERB B-O -in ADP B-O -various ADJ B-O -coupling NOUN B-O -metrics NOUN B-O -, PUNCT B-O -which PRON B-O -can AUX B-O -be AUX B-O -considered VERB B-O -as ADP B-O -assessor NOUN B-O -of ADP B-O -design NOUN B-O -stability NOUN B-O -of ADP B-O -classes NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -Coupling NOUN B-LF -Between ADP I-LF -Object PROPN I-LF -( PUNCT B-O -CBO PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Response NOUN B-LF -For ADP I-LF -a DET I-LF -Class NOUN I-LF -( PUNCT B-O -RFC PROPN B-AC -) PUNCT B-O -from ADP B-O -Chidamber PROPN B-O -and CCONJ B-O -Kemerer PROPN B-O -’s PART B-O -metrics NOUN B-O -suit VERB B-O -[ PUNCT B-O -9 NUM B-O -, PUNCT B-O -11 NUM B-O -] PUNCT B-O -, PUNCT B-O -Data PROPN B-LF -Abstraction NOUN I-LF -Coupling NOUN I-LF -( PUNCT B-O -DAC PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Measure NOUN B-LF -of ADP I-LF -Aggregation NOUN I-LF -( PUNCT B-O -MOA PROPN B-AC -) PUNCT B-O -from ADP B-O -QMOOD PROPN B-O -[ PUNCT B-O -10 NUM B-O -] PUNCT B-O -and CCONJ B-O -Message NOUN B-LF -Passing NOUN I-LF -Coupling NOUN I-LF -( PUNCT B-O -MPC PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -12 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Peripheral ADJ B-O -blood NOUN B-O -mononuclear ADJ B-O -cells NOUN B-O -from ADP B-O -intensive ADJ B-LF -care NOUN I-LF -unit NOUN I-LF -( PUNCT B-O -ICU PROPN B-AC -) PUNCT B-O -patients NOUN B-O -with ADP B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -30 NUM B-O -) PUNCT B-O -and CCONJ B-O -without ADP B-O -sepsis NOUN B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -10 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -healthy ADJ B-O -volunteers NOUN B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -15 NUM B-O -) PUNCT B-O -were AUX B-O -isolated VERB B-O -using VERB B-O -Ficoll PROPN B-O -density NOUN B-O -gradient NOUN B-O -centrifugation NOUN B-O -. PUNCT B-O - -The DET B-O -data NOUN B-O -were AUX B-O -then ADV B-O -separated VERB B-O -into ADP B-O -local ADJ B-LF -field NOUN I-LF -potentials NOUN I-LF -( PUNCT B-O -LFPs PROPN B-AC -; PUNCT B-O -1–150 NUM B-O -Hz NOUN B-O -) PUNCT B-O -and CCONJ B-O -isolated VERB B-O -single ADJ B-O -- PUNCT B-O -unit NOUN B-O -activity NOUN B-O -( PUNCT B-O -0.5–10 NUM B-O -kHz NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Prostate ADJ B-LF -cancer NOUN I-LF -( PUNCT B-O -PCa PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -most ADV B-O -common ADJ B-O -malignancy NOUN B-O -in ADP B-O -men NOUN B-O -and CCONJ B-O -is AUX B-O -the DET B-O -second ADJ B-O -leading VERB B-O -cause NOUN B-O -of ADP B-O -cancer NOUN B-O -deaths NOUN B-O -worldwide ADV B-O -. PUNCT B-O - -Whereas SCONJ B-O -the DET B-O -impact NOUN B-O -of ADP B-O -the DET B-O -G PROPN B-O -allele NOUN B-O -on ADP B-O -the DET B-O -liver NOUN B-O -fibrosis NOUN B-O -progression NOUN B-O -in ADP B-O -chronic ADJ B-O -hepatitis NOUN B-O -C PROPN B-O -seems VERB B-O -to PART B-O -be AUX B-O -well ADV B-O -known VERB B-O -, PUNCT B-O -its PRON B-O -impact NOUN B-O -on ADP B-O -chronic ADJ B-LF -liver NOUN I-LF -failure NOUN I-LF -( PUNCT B-O -CLF PROPN B-AC -) PUNCT B-O -progression NOUN B-O -and CCONJ B-O -the DET B-O -need NOUN B-O -of ADP B-O -LT PROPN B-AC -has AUX B-O -not PART B-O -been AUX B-O -described VERB B-O -so ADV B-O -far ADV B-O -. PUNCT B-O - -First ADV B-O -, PUNCT B-O -S PROPN B-AC -forms VERB B-O -Watson PROPN B-O -– PUNCT B-O -Crick PROPN B-O -base NOUN B-O -pairs NOUN B-O -with ADP B-O -the DET B-O -ribozyme NOUN B-LF -'s PART B-O -internal ADJ B-O -guide NOUN B-O -sequence NOUN B-O -( PUNCT B-O -see VERB B-O -Figure PROPN B-O -2A NUM B-O -) PUNCT B-O -to PART B-O -give VERB B-O -the DET B-O -open ADJ B-O -complex NOUN B-O -( PUNCT B-O -In ADP B-O -total NOUN B-O -, PUNCT B-O -these DET B-O -US PROPN B-O -healthcare NOUN B-O -- PUNCT B-O -related VERB B-O -emissions NOUN B-O -result VERB B-O -in ADP B-O -an DET B-O -estimated VERB B-O -annual ADJ B-O -loss NOUN B-O -of ADP B-O -614,000 NUM B-O -disability NOUN B-LF -- PUNCT I-LF -adjusted VERB I-LF -life NOUN I-LF -years NOUN I-LF -( PUNCT B-O -DALYs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -only ADJ B-O -such ADJ B-O -national ADJ B-O -damage NOUN B-O -estimate NOUN B-O -to ADP B-O -date NOUN B-O -[ PUNCT B-O -7,24 NUM B-O -] PUNCT B-O -. PUNCT B-O - -For ADP B-O -example NOUN B-O -, PUNCT B-O -one NUM B-O -pair NOUN B-O -from ADP B-O -this DET B-O -region NOUN B-O -is AUX B-O -shown VERB B-O -to ADP B-O -be AUX B-O -expressed VERB B-O -from ADP B-O -chromosome NOUN B-O -8q24.21 NUM B-O -, PUNCT B-O -and CCONJ B-O -it PRON B-O -forms VERB B-O -a DET B-O -stable ADJ B-O -ndsRNA PROPN B-AC -molecule NOUN B-O -( PUNCT B-O -nds-2a NOUN B-O -) PUNCT B-O -that PRON B-O -binds VERB B-O -to ADP B-O -regulator NOUN B-LF -of ADP I-LF -chromosome NOUN I-LF -condensation NOUN I-LF -1 NUM I-LF -( PUNCT B-O -RCC1 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -ras NOUN B-LF -- PUNCT I-LF -related VERB I-LF -nuclear ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -RAN PROPN B-AC -) PUNCT B-O -and CCONJ B-O -through ADP B-O -the DET B-O -latter ADJ B-O -, PUNCT B-O -with ADP B-O -the DET B-O -mitotic ADJ B-O -RANGAP1 NOUN B-O -- PUNCT B-O -SUMO1 NOUN B-O -- PUNCT B-O -RANBP2 NOUN B-O -complex NOUN B-O -[ PUNCT B-O -64 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -gene NOUN B-O -expression NOUN B-O -of ADP B-O -FA PROPN B-AC -synthase NOUN B-O -( PUNCT B-O -FASN PROPN B-AC -) PUNCT B-O -, PUNCT B-O -lipoprotein NOUN B-LF -lipase NOUN I-LF -( PUNCT B-O -LPL PROPN B-AC -) PUNCT B-O -, PUNCT B-O -stearoyl NOUN B-O -- PUNCT B-O -CoA NOUN B-O -desaturase NOUN B-O -( PUNCT B-O -SCD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -FA PROPN B-AC -desaturase NOUN B-O -1 NUM B-O -( PUNCT B-O -FADS1 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -FA PROPN B-AC -elongase NOUN B-O -5 NUM B-O -( PUNCT B-O -ELOVL5 PROPN B-AC -) PUNCT B-O -were AUX B-O -measured VERB B-O -in ADP B-O -muscle NOUN B-O -. PUNCT B-O - -Interactions NOUN B-O -of ADP B-O -MYPT1 PROPN B-AC -and CCONJ B-O -its PRON B-O -mutants NOUN B-O -with ADP B-O -SNAP-25 PROPN B-AC -were AUX B-O -analysed VERB B-O -by ADP B-O -surface NOUN B-LF -plasmon NOUN I-LF -resonance NOUN I-LF -( PUNCT B-O -SPR PROPN B-AC -) PUNCT B-O -using VERB B-O -a DET B-O -Biacore PROPN B-O -3000 NUM B-O -instrument NOUN B-O -( PUNCT B-O -GE PROPN B-O -Healthcare PROPN B-O -, PUNCT B-O -Little PROPN B-O -Chalfont PROPN B-O -, PUNCT B-O -UK PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Anti NOUN B-O -- PUNCT B-O -GST PROPN B-O -was AUX B-O -coupled VERB B-O -on ADP B-O -the DET B-O -surface NOUN B-O -of ADP B-O -a DET B-O -CM5 PROPN B-O -chip NOUN B-O -by ADP B-O -amine NOUN B-O -- PUNCT B-O -coupling NOUN B-O -, PUNCT B-O -then ADV B-O -full ADJ B-O -- PUNCT B-O -length ADJ B-O -GST PROPN B-O -- PUNCT B-O -MYPT1WT NOUN B-O -or CCONJ B-O -its PRON B-O -C NOUN B-O -- PUNCT B-O -terminal NOUN B-O -fragment NOUN B-O -( PUNCT B-O -GST PROPN B-O -- PUNCT B-O -MYPT1667–1004 PROPN B-O -) PUNCT B-O -was AUX B-O -captured VERB B-O -on ADP B-O -the DET B-O -surface NOUN B-O -. PUNCT B-O - -Our PRON B-O -estimates NOUN B-O -( PUNCT B-O -black ADJ B-O -) PUNCT B-O -of ADP B-O -the DET B-O -excess ADJ B-LF -hazard NOUN I-LF -- PUNCT I-LF -months NOUN I-LF -attributable ADJ I-LF -to ADP I-LF -the DET I-LF -acute ADJ I-LF -phase NOUN I-LF -( PUNCT B-O -EHMacute PROPN B-AC -) PUNCT B-O -based VERB B-O -on ADP B-O -( PUNCT B-O -A NOUN B-O -) PUNCT B-O -viral ADJ B-O -load NOUN B-O -trajectories NOUN B-O -( PUNCT B-O -Fig NOUN B-O -. PUNCT B-O - -2 NUM B-O -) PUNCT B-O -and CCONJ B-O -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -our PRON B-O -fit NOUN B-O -of ADP B-O -a DET B-O -couples NOUN B-O -transmission NOUN B-O -model NOUN B-O -to ADP B-O -the DET B-O -Rakai PROPN B-O -retrospective ADJ B-O -cohort NOUN B-O -. PUNCT B-O - -These PRON B-O -comprise VERB B-O -: PUNCT B-O -release NOUN B-O -from ADP B-O -chaperones NOUN B-O -and CCONJ B-O -co NOUN B-O -- PUNCT B-O -chaperones NOUN B-O -, PUNCT B-O -trimerization NOUN B-O -via ADP B-O -an DET B-O -unmasked ADJ B-O -coiled VERB B-O -- PUNCT B-O -coil NOUN B-O -domain NOUN B-O -, PUNCT B-O -binding NOUN B-O -to ADP B-O -its PRON B-O -cognate NOUN B-O -DNA NOUN B-O -sequences NOUN B-O -in ADP B-O -regulatory ADJ B-O -regions NOUN B-O -of ADP B-O -target NOUN B-O -genes NOUN B-O -, PUNCT B-O -and CCONJ B-O -stimulation NOUN B-O -of ADP B-O -the DET B-O -transactivation NOUN B-O -potential NOUN B-O -via ADP B-O -the DET B-O -calcium NOUN B-LF -/ SYM I-LF -calmodulin NOUN I-LF -- PUNCT I-LF -dependent ADJ I-LF -kinase NOUN I-LF -II NUM I-LF -( PUNCT B-O -CAMKII)-mediated PROPN B-AC -phosphorylation NOUN B-O -of ADP B-O -a DET B-O -serine NOUN B-O -residue NOUN B-O -within ADP B-O -the DET B-O -HSF1 PROPN B-O -regulatory ADJ B-O -domain NOUN B-O -[ PUNCT B-O -38 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Patients NOUN B-O -with ADP B-O -hepatocellular ADJ B-LF -carcinoma NOUN I-LF -( PUNCT B-O -HCC PROPN B-AC -) PUNCT B-O -submitted VERB B-O -to ADP B-O -orthotopic ADJ B-LF -liver NOUN I-LF -transplantation NOUN I-LF -( PUNCT B-O -OLT PROPN B-AC -) PUNCT B-O -have VERB B-O -a DET B-O -variable ADJ B-O -5 NUM B-O -- PUNCT B-O -year NOUN B-O -survival NOUN B-O -rate NOUN B-O -limited VERB B-O -mostly ADV B-O -by ADP B-O -tumor NOUN B-O -recurrence NOUN B-O -. PUNCT B-O - -All DET B-O -data NOUN B-O -in ADP B-O -this DET B-O -study NOUN B-O -are AUX B-O -computed VERB B-O -with ADP B-O -their PRON B-O -95 NUM B-O -% NOUN B-O -uncertainty NOUN B-LF -intervals NOUN I-LF -( PUNCT B-O -UIs PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -13–17 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -oxidative ADJ B-O -fluorescent ADJ B-O -dye NOUN B-O -, PUNCT B-O -DHE PROPN B-AC -, PUNCT B-O -was AUX B-O -freely ADV B-O -permeable ADJ B-O -to ADP B-O -cells NOUN B-O -, PUNCT B-O -and CCONJ B-O -in ADP B-O -the DET B-O -presence NOUN B-O -of ADP B-O -O2- NOUN B-O -was AUX B-O -oxidized VERB B-O -to ADP B-O -ethidium NOUN B-LF -bromide NOUN I-LF -( PUNCT B-O -EtBr PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -was AUX B-O -trapped VERB B-O -by ADP B-O -intercalation NOUN B-O -with ADP B-O -DNA PROPN B-O -. PUNCT B-O - -EtBr PROPN B-AC -was AUX B-O -excited VERB B-O -at ADP B-O -488 NUM B-O -nm NOUN B-O -with ADP B-O -an DET B-O -emission NOUN B-O -spectrum NOUN B-O -of ADP B-O -610 NUM B-O -nm NOUN B-O -. PUNCT B-O - -The DET B-O -physiological ADJ B-O -factors NOUN B-O -which PRON B-O -affect VERB B-O -left ADJ B-LF -ventricular ADJ I-LF -( PUNCT B-O -LV PROPN B-AC -) PUNCT B-O -long ADJ B-O -- PUNCT B-O -axis NOUN B-O -function NOUN B-O -are AUX B-O -not PART B-O -fully ADV B-O -defined VERB B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -AM PROPN B-AC -, PUNCT B-O -acute ADJ B-LF -malnutrition NOUN I-LF -; PUNCT B-O -BCC PROPN B-AC -, PUNCT B-O -behavior NOUN B-LF -change NOUN I-LF -communication NOUN I-LF -; PUNCT B-O -CMAM PROPN B-AC -, PUNCT B-O -community NOUN B-O -management NOUN B-O -of ADP B-O -AM PROPN B-AC -; PUNCT B-O -CNS PROPN B-AC -, PUNCT B-O -well ADJ B-O -- PUNCT B-O -baby NOUN B-O -consultation NOUN B-O -; PUNCT B-O -MAM PROPN B-AC -, PUNCT B-O -moderate ADJ B-O -AM PROPN B-AC -; PUNCT B-O -MUAC PROPN B-AC -, PUNCT B-O -mid ADJ B-LF -- PUNCT I-LF -upper ADJ I-LF -arm NOUN I-LF -circumference NOUN I-LF -; PUNCT B-O -SAM PROPN B-AC -, PUNCT B-O -severe ADJ B-O -AM PROPN B-AC -; PUNCT B-O -SQ PROPN B-AC -, PUNCT B-O -small ADJ B-O -- PUNCT B-O -quantity NOUN B-O -lipid NOUN B-O -- PUNCT B-O -based VERB B-O -nutrition NOUN B-O -supplement NOUN B-O -; PUNCT B-O --LNSWLZ PROPN B-AC -, PUNCT B-O -weight NOUN B-LF -- PUNCT I-LF -for ADP I-LF -- PUNCT I-LF -length NOUN I-LF -z NOUN I-LF -- PUNCT I-LF -score NOUN I-LF -A DET B-O -candidate NOUN B-O -target NOUN B-O -pathway NOUN B-O -is AUX B-O -quorum NOUN B-LF -sensing NOUN I-LF -( PUNCT B-O -QS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -many ADJ B-O -bacterial ADJ B-O -pathogens NOUN B-O -use VERB B-O -to PART B-O -coordinately ADV B-O -regulate VERB B-O -virulence NOUN B-O -determinants NOUN B-O -. PUNCT B-O - -In ADP B-O -order NOUN B-O -to PART B-O -understand VERB B-O -how SCONJ B-O -p84 NOUN B-O -could AUX B-O -mask VERB B-O -Ser582 NOUN B-O -phosphorylation NOUN B-O -, PUNCT B-O -and CCONJ B-O -to PART B-O -map VERB B-O -the DET B-O -p110γ NOUN B-O -- PUNCT B-O -p84 NOUN B-O -contact NOUN B-O -interface NOUN B-O -, PUNCT B-O -hydrogen NOUN B-LF -deuterium NOUN I-LF -exchange NOUN I-LF -mass NOUN I-LF -spectrometry NOUN I-LF -( PUNCT B-O -HDX-MS PROPN B-AC -) PUNCT B-O -was AUX B-O -used VERB B-O -. PUNCT B-O - -In ADP B-O -more ADJ B-O -than ADP B-O -400 NUM B-O -studies NOUN B-O -compiled VERB B-O -in ADP B-O -the DET B-O -GWAS PROPN B-AC -catalog NOUN B-O -[ PUNCT B-O -108 NUM B-O -] PUNCT B-O -, PUNCT B-O -only ADV B-O -a DET B-O -small ADJ B-O -minority NOUN B-O -of ADP B-O -the DET B-O -trait NOUN B-LF -/ SYM I-LF -disease NOUN I-LF -- PUNCT I-LF -associated VERB I-LF -SNPs NOUN I-LF -( PUNCT B-O -TASs PROPN B-AC -) NOUN B-O -occur VERB B-O -in ADP B-O -protein NOUN B-O -- PUNCT B-O -coding VERB B-O -regions NOUN B-O -; PUNCT B-O -the DET B-O -large ADJ B-O -majority NOUN B-O -( PUNCT B-O -89 NUM B-O -% NOUN B-O -) NOUN B-O -are AUX B-O -in ADP B-O -noncoding ADJ B-O -regions NOUN B-O -. PUNCT B-O - -Statistical ADJ B-O -comparisons NOUN B-O -were AUX B-O -performed VERB B-O -with ADP B-O -a DET B-O -2 NUM B-O -- PUNCT B-O -way NOUN B-O -ANOVA NOUN B-O -using VERB B-O -time NOUN B-O -and CCONJ B-O -genotype NOUN B-O -as ADP B-O -factors NOUN B-O -, PUNCT B-O -followed VERB B-O -by ADP B-O -post ADJ B-O -hoc ADJ B-O -pairwise ADJ B-O -comparisons NOUN B-O -at ADP B-O -each DET B-O -time NOUN B-O -point NOUN B-O -to ADP B-O -obtain VERB B-O -nominal ADJ B-O -p NOUN B-O -- PUNCT B-O -values NOUN B-O -, PUNCT B-O -which PRON B-O -were AUX B-O -subjected VERB B-O -to ADP B-O -a DET B-O -Tukey PROPN B-O -correction NOUN B-O -for ADP B-O -multiple ADJ B-O -comparisons NOUN B-O -( PUNCT B-O -S1 PROPN B-O -Data PROPN B-O -, PUNCT B-O -Sheet PROPN B-O -1 NUM B-O -G PROPN B-O -) PUNCT B-O -. PUNCT B-O - -AMPK PROPN B-AC -, PUNCT B-O -adenosine NOUN B-LF -monophosphate NOUN I-LF -regulated VERB I-LF -protein NOUN I-LF -kinase NOUN I-LF -; PUNCT B-O -DTS PROPN B-AC -, PUNCT B-O -developmentally ADV B-LF -timed VERB I-LF -sleep NOUN I-LF -; PUNCT B-O -L1 PROPN B-AC -stage NOUN B-O -, PUNCT B-O -first ADJ B-LF -larval ADJ I-LF -stage NOUN I-LF -; PUNCT B-O -ns PROPN B-AC -, PUNCT B-O -not PART B-LF -significant ADJ I-LF -; PUNCT B-O -p PROPN B-AC --AMPK PROPN B-AC -, PUNCT B-O -phosphorylated VERB B-LF -AMPK NOUN I-LF -AMPK PROPN B-AC -; PUNCT B-O -SIS PROPN B-AC -, PUNCT B-O -stress NOUN B-LF -- PUNCT I-LF -induced VERB I-LF -sleep NOUN I-LF -; PUNCT B-O -UVC PROPN B-AC -, PUNCT B-O -ultraviolet ADJ B-LF -C NOUN I-LF -; PUNCT B-O -WT PROPN B-O -, PUNCT B-O -wild ADJ B-O -type NOUN B-O -. PUNCT B-O - -Logistic ADJ B-O -regression NOUN B-O -analysis NOUN B-O -showed VERB B-O -that SCONJ B-O -the DET B-O -independent ADJ B-O -factors NOUN B-O -associated VERB B-O -with ADP B-O -mortality NOUN B-O -were AUX B-O -postoperative ADJ B-O -lactate ADJ B-O -level NOUN B-O -( PUNCT B-O -odds NOUN B-LF -ratio NOUN I-LF -[ X B-O -OR PROPN B-AC -] X B-O -1.926 NUM B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval NOUN I-LF -[ X B-O -CI PROPN B-AC -] X B-O -1.101–3.089 NUM B-O -, PUNCT B-O -p NOUN B-O -= SYM B-O -0.007 NUM B-O -) PUNCT B-O -, PUNCT B-O -postoperative ADJ B-O -sequential ADJ B-O -organ NOUN B-O -failure NOUN B-O -assessment NOUN B-O -score NOUN B-O -( PUNCT B-O -OR PROPN B-AC -1.593 NUM B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -1.160–2.187 NUM B-O -, PUNCT B-O -p NOUN B-O -= SYM B-O -0.004 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -DNI PROPN B-AC -on ADP B-O -POD1 PROPN B-O -( PUNCT B-O -OR PROPN B-AC -1.118 NUM B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -1.028–1.215 NUM B-O -, PUNCT B-O -p NOUN B-O -= SYM B-O -0.009 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Missing VERB B-O -values NOUN B-O -in ADP B-O -NSDUH PROPN B-AC -are AUX B-O -imputed VERB B-O -by ADP B-O -SAMHSA PROPN B-AC -prior ADV B-O -to ADP B-O -release NOUN B-O -of ADP B-O -the DET B-O -dataset NOUN B-O -using VERB B-O -a DET B-O -predictive ADJ B-LF -mean ADJ I-LF -neighborhood NOUN I-LF -( PUNCT B-O -PMN PROPN B-AC -) PUNCT B-O -and CCONJ B-O -a DET B-O -modified VERB B-O -PMN PROPN B-AC -as SCONJ B-O -detailed VERB B-O -in ADP B-O -the DET B-O -NSDUH PROPN B-AC -codebook NOUN B-O -[ PUNCT B-O -26 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Mutation NOUN B-O -of ADP B-O -serine NOUN B-LF -( PUNCT B-O -S PROPN B-AC -) PUNCT B-O -424 NUM B-O -to ADP B-O -alanine NOUN B-LF -( PUNCT B-O -A PROPN B-AC -) PUNCT B-O -( PUNCT B-O -mimics NOUN B-O -dephosphorylation NOUN B-O -) PUNCT B-O -inhibits VERB B-O -HDAC3 PROPN B-AC -enzyme NOUN B-O -activity NOUN B-O -without ADP B-O -affecting VERB B-O -its PRON B-O -expression NOUN B-O -or CCONJ B-O -subcellular ADJ B-O -localization NOUN B-O -[ PUNCT B-O -38 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -data NOUN B-O -from ADP B-O -the DET B-O -fatty ADJ B-O -acid NOUN B-O -compositions NOUN B-O -were AUX B-O -used VERB B-O -to ADP B-O -investigate VERB B-O -the DET B-O -nutritional ADJ B-O -lipid NOUN B-O -quality NOUN B-O -indices NOUN B-O -from ADP B-O -the DET B-O -five NUM B-O -evaluated VERB B-O -freshwater NOUN B-O -fish NOUN B-O -species NOUN B-O -through ADP B-O -three NUM B-O -important ADJ B-O -indicators NOUN B-O -, PUNCT B-O -namely ADV B-O -, PUNCT B-O -index NOUN B-LF -of ADP I-LF -atherogenicity NOUN I-LF -( PUNCT B-O -IA PROPN B-AC -) X B-O -and CCONJ B-O -index NOUN B-LF -of ADP I-LF -thrombogenicity NOUN I-LF -( PUNCT B-O -IT PROPN B-AC -) X B-O -, PUNCT B-O -according VERB B-O -to ADP B-O -Ulbricht PROPN B-O -and CCONJ B-O -Southgate PROPN B-O -[ X B-O -37 NUM B-O -] PUNCT B-O -with ADP B-O -modifications NOUN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -hypocholesterolemic ADJ B-LF -/ SYM I-LF -hypercholesterolemic ADJ I-LF -ratio NOUN I-LF -( PUNCT B-O -h PROPN B-AC -) X B-O -according VERB B-O -to ADP B-O -Santos PROPN B-O -- PUNCT B-O -Silva PROPN B-O -, PUNCT B-O -Bessa PROPN B-O -, PUNCT B-O -and CCONJ B-O -Santos PROPN B-O -- PUNCT B-O -Silva PROPN B-O -[ X B-O -38 NUM B-O -] PUNCT B-O -, PUNCT B-O -as SCONJ B-O -follows VERB B-O -: PUNCT B-O -/HIA=(4×C14:0+C16:0)/(∑MUFA+∑(n–6)+∑(n–3))IT=(C14:0+C16:0+C18:0)/(0.5×∑MUFA+0.5×∑(n–6)+3×∑(n–3)+100×∑(n–3)/∑(n–6))h PROPN B-AC -+ X B-O -16:0 NUM B-O -) X B-O -A DET B-O -retrospective ADJ B-O -cross ADJ B-O -- ADJ B-O -sectional ADJ B-O -study NOUN B-O -was AUX B-O -conducted VERB B-O -on ADP B-O -medical ADJ B-O -records NOUN B-O -of ADP B-O -patients NOUN B-O -admitted VERB B-O -from ADP B-O -August PROPN B-O -1 NUM B-O -, PUNCT B-O -2013‒July NUM B-O -31 NUM B-O -, PUNCT B-O -2018 NUM B-O -in ADP B-O -Ayder PROPN B-LF -Comprehensive PROPN I-LF -Specialized PROPN I-LF -Hospital PROPN I-LF -( PUNCT B-O -ACSH PROPN B-AC -) PUNCT B-O -, PUNCT B-O -found VERB B-O -in ADP B-O -Mekelle PROPN B-O -, PUNCT B-O -the DET B-O -capital NOUN B-O -city NOUN B-O -of ADP B-O -Tigray PROPN B-O -regional ADJ B-O -state NOUN B-O -, PUNCT B-O -783 NUM B-O -Kilometers NOUN B-O -away ADV B-O -from ADP B-O -Addis PROPN B-O -Ababa PROPN B-O -, PUNCT B-O -Ethiopia PROPN B-O -. PUNCT B-O - -U2OS PROPN B-O -reporter NOUN B-O -cell NOUN B-O -lines NOUN B-O -specifically ADV B-O -designed VERB B-O -to PART B-O -repair NOUN B-O -DNA NOUN B-O -damage NOUN B-O -through ADP B-O -nonhomologous ADJ B-LF -end NOUN I-LF -joining NOUN I-LF -( PUNCT B-O -NHEJ PROPN B-AC -) PUNCT B-O -and CCONJ B-O -homology NOUN B-LF -- PUNCT I-LF -directed VERB I-LF -repair NOUN I-LF -( PUNCT B-O -HDR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -were AUX B-O -transfected VERB B-O -with ADP B-O -nonspecific ADJ B-O -control NOUN B-O -( PUNCT B-O -si PROPN B-AC -) PUNCT B-O -or CCONJ B-O --NCSam68 PROPN B-AC -- PUNCT B-O -specific ADJ B-O -( PUNCT B-O -si NOUN B-O -- PUNCT B-O -Sam68 PROPN B-AC -) PUNCT B-O -small ADJ B-O -interference NOUN B-O -RNA NOUN B-O -, PUNCT B-O -together ADV B-O -with ADP B-O -( PUNCT B-O -+ PUNCT B-O -) PUNCT B-O -or CCONJ B-O -without ADP B-O -( PUNCT B-O -− PUNCT B-O -) PUNCT B-O -I NOUN B-O -- PUNCT B-O -SceI PROPN B-O -plasmid NOUN B-O -, PUNCT B-O -or CCONJ B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -GFP PROPN B-AC -) PUNCT B-O -control NOUN B-O -. PUNCT B-O - -The DET B-O -carboxysome NOUN B-O -is AUX B-O -a DET B-O -bacterial ADJ B-O -organelle NOUN B-O -that PRON B-O -functions VERB B-O -to PART B-O -enhance VERB B-O -the DET B-O -efficiency NOUN B-O -of ADP B-O -CO2 NOUN B-O -fixation NOUN B-O -by ADP B-O -encapsulating VERB B-O -the DET B-O -enzymes NOUN B-O -ribulose NOUN B-LF -bisphosphate NOUN I-LF -carboxylase NOUN I-LF -/ SYM I-LF -oxygenase NOUN I-LF -( PUNCT B-O -RuBisCO PROPN B-AC -) PUNCT B-O -and CCONJ B-O -carbonic ADJ B-O -anhydrase NOUN B-O -. PUNCT B-O - -The DET B-O -following ADJ B-O -ELISA PROPN B-O -kits NOUN B-O -were AUX B-O -used VERB B-O -: PUNCT B-O -LRG1 PROPN B-AC -ELISA PROPN B-O -kit NOUN B-O -( PUNCT B-O -Cosmic PROPN B-O -Corporation PROPN B-O -, PUNCT B-O -Tokyo PROPN B-O -, PUNCT B-O -Japan PROPN B-O -, PUNCT B-O -product NOUN B-O -number NOUN B-O -; PUNCT B-O -T131C100 NUM B-O -) PUNCT B-O -and CCONJ B-O -Human PROPN B-O -Total PROPN B-O -Angiotensinogen PROPN B-LF -( PUNCT B-O -AGT PROPN B-AC -) PUNCT B-O -Assay PROPN B-O -Kit PROPN B-O -( PUNCT B-O -Immuno PROPN B-O -- PUNCT B-O -Biological PROPN B-O -Laboratories PROPN B-O -, PUNCT B-O -Gunma PROPN B-O -, PUNCT B-O -Japan PROPN B-O -, PUNCT B-O -product NOUN B-O -number NOUN B-O -; PUNCT B-O -27412 NUM B-O -) PUNCT B-O -. PUNCT B-O - -We PRON B-O -prospectively ADV B-O -collected VERB B-O -peripheral ADJ B-LF -blood NOUN I-LF -mononuclear ADJ I-LF -cells NOUN I-LF -( PUNCT B-O -PBMCs PROPN B-AC -) PUNCT B-O -by ADP B-O -leukapheresis NOUN B-O -from ADP B-O -a DET B-O -55 NUM B-O -- PUNCT B-O -year NOUN B-O -- PUNCT B-O -old ADJ B-O -man NOUN B-O -with ADP B-O -chronic ADJ B-O -HIV PROPN B-O -infection NOUN B-O -before ADP B-O -and CCONJ B-O -after ADP B-O -allo-SCT PROPN B-AC -to PART B-O -measure VERB B-O -the DET B-O -size NOUN B-O -of ADP B-O -the DET B-O -HIV-1 PROPN B-O -reservoir NOUN B-O -and CCONJ B-O -characterize VERB B-O -viral ADJ B-O -phylogeny NOUN B-O -and CCONJ B-O -phenotypic ADJ B-O -changes NOUN B-O -in ADP B-O -immune ADJ B-O -cells NOUN B-O -. PUNCT B-O - -Outcome NOUN B-O -measures NOUN B-O -were AUX B-O -deaths NOUN B-O -, PUNCT B-O -along ADP B-O -with ADP B-O -nonfatal ADJ B-O -myocardial ADJ B-LF -infarction NOUN I-LF -( PUNCT B-O -MI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -stroke NOUN B-O -, PUNCT B-O -congestive ADJ B-LF -heart NOUN I-LF -failure NOUN I-LF -( PUNCT B-O -CHF PROPN B-AC -) PUNCT B-O -, PUNCT B-O -transient ADJ B-LF -ischemic ADJ I-LF -attack NOUN I-LF -( PUNCT B-O -TIA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -antihypertensive ADJ B-O -treatment NOUN B-O -recorded VERB B-O -from ADP B-O -structured VERB B-O -interviews NOUN B-O -at ADP B-O -scheduled VERB B-O -intervals NOUN B-O -. PUNCT B-O - -At ADP B-O -GW PROPN B-O -15–26 NUM B-O -, PUNCT B-O -a DET B-O -standard ADJ B-LF -deviation NOUN I-LF -( PUNCT B-O -SD PROPN B-AC -) PUNCT B-O -increase NOUN B-O -in ADP B-O -total ADJ B-O -n-3 NOUN B-O -PUFAs PROPN B-AC -and CCONJ B-O -individual ADJ B-O -n-3 NOUN B-O -DPA PROPN B-AC -was AUX B-O -associated VERB B-O -with ADP B-O -a DET B-O -36 NUM B-O -% NOUN B-O -( PUNCT B-O -adjusted VERB B-O -odds NOUN B-O -ratio NOUN B-O -0.64 NUM B-O -; PUNCT B-O -95 NUM B-O -% NOUN B-O -CI NOUN B-O -0.42–0.96 NUM B-O -; PUNCT B-O -P NOUN B-O -= SYM B-O -0.042 NUM B-O -) PUNCT B-O -and CCONJ B-O -33 NUM B-O -% NOUN B-O -( PUNCT B-O -0.67 NUM B-O -; PUNCT B-O -95 NUM B-O -% NOUN B-O -CI NOUN B-O -0.45–0.99 NUM B-O -; PUNCT B-O -P NOUN B-O -= SYM B-O -0.047 NUM B-O -) PUNCT B-O -lower ADJ B-O -risk NOUN B-O -of ADP B-O -GDM PROPN B-AC -, PUNCT B-O -respectively ADV B-O -; PUNCT B-O -however ADV B-O -, PUNCT B-O -the DET B-O -significance NOUN B-O -did AUX B-O -not PART B-O -persist VERB B-O -after ADP B-O -post X B-O -hoc X B-O -false ADJ B-O -- PUNCT B-O -discovery NOUN B-O -rate NOUN B-O -( PUNCT B-O -FDR PROPN B-AC -) PUNCT B-O -correction NOUN B-O -( PUNCT B-O -FDR PROPN B-AC -- PUNCT B-O -corrected VERB B-O -P NOUN B-O -values NOUN B-O -> SYM B-O -0.05 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Terminal ADJ B-O -hypertrophic ADJ B-O -differentiation NOUN B-O -is AUX B-O -accompanied VERB B-O -by ADP B-O -a DET B-O -massive ADJ B-O -increase NOUN B-O -in ADP B-O -cell NOUN B-O -volume NOUN B-O -and CCONJ B-O -expression NOUN B-O -of ADP B-O -alkaline ADJ B-LF -phosphatase NOUN I-LF -( PUNCT B-O -ALP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -an DET B-O -enzyme NOUN B-O -required VERB B-O -for ADP B-O -mineralization NOUN B-O -of ADP B-O -cartilage NOUN B-O -[ PUNCT B-O -20 NUM B-O -] PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -the DET B-O -first ADJ B-O -step NOUN B-O -in ADP B-O -cartilage NOUN B-O -remodeling NOUN B-O -. PUNCT B-O - -We PRON B-O -next ADV B-O -asked VERB B-O -whether SCONJ B-O -the DET B-O -surface NOUN B-O -polarization NOUN B-O -of ADP B-O -other ADJ B-O -axonal ADJ B-O -membrane NOUN B-O -proteins NOUN B-O -was AUX B-O -affected VERB B-O -in ADP B-O -the DET B-O -absence NOUN B-O -of ADP B-O -SorCS1 PROPN B-AC -. PUNCT B-O - -The DET B-O -cell NOUN B-O -adhesion NOUN B-O -molecules NOUN B-O -neuron NOUN B-LF -- PUNCT I-LF -glia NOUN I-LF -cell NOUN I-LF -adhesion NOUN I-LF -molecule NOUN I-LF -L1 NOUN I-LF -( PUNCT B-O -L1/NgCAM PROPN B-AC -) PUNCT B-O -and CCONJ B-O -contactin NOUN B-LF -- PUNCT I-LF -associated VERB I-LF -protein NOUN I-LF -- PUNCT I-LF -like ADJ I-LF -2 NUM I-LF -( PUNCT B-O -Caspr2 PROPN B-AC -) PUNCT B-O -are AUX B-O -both PRON B-O -targeted VERB B-O -to ADP B-O -the DET B-O -axonal ADJ B-O -surface NOUN B-O -but CCONJ B-O -via ADP B-O -distinct ADJ B-O -trafficking NOUN B-O -routes NOUN B-O -. PUNCT B-O - -These DET B-O -CRMs PROPN B-AC -act VERB B-O -as ADP B-O -neurogenic ADJ B-LF -ectoderm NOUN I-LF -enhancers NOUN I-LF -( PUNCT B-O -NEEs PROPN B-AC -) PUNCT B-O -and CCONJ B-O -function VERB B-O -to PART B-O -drive VERB B-O -gene NOUN B-O -expression NOUN B-O -in ADP B-O -the DET B-O -early ADJ B-O -embryonic ADJ B-O -neuroectoderm NOUN B-O -before SCONJ B-O -gastrulation NOUN B-O -has AUX B-O -commenced VERB B-O -[ PUNCT B-O -36 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -autoxidation NOUN B-O -of ADP B-O -intracellular ADJ B-O -oxyHb NOUN B-O -and CCONJ B-O -downstream ADJ B-O -free ADJ B-O -radical NOUN B-O -formation NOUN B-O -is AUX B-O -prevented VERB B-O -mainly ADV B-O -by ADP B-O -superoxide NOUN B-LF -dismutase NOUN I-LF -( PUNCT B-O -SOD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -catalase NOUN B-O -and CCONJ B-O -glutathione NOUN B-LF -peroxidase NOUN I-LF -( PUNCT B-O -GPx PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -18,19 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This DET B-O -paper NOUN B-O -examines VERB B-O -whether SCONJ B-O -practices NOUN B-O -regarding VERB B-O -consent NOUN B-O -, PUNCT B-O -confidentiality NOUN B-O -, PUNCT B-O -and CCONJ B-O -referral NOUN B-O -vary VERB B-O -depending VERB B-O -on ADP B-O -whether SCONJ B-O -testing NOUN B-O -is AUX B-O -provided VERB B-O -through ADP B-O -voluntary ADJ B-LF -counseling NOUN I-LF -and CCONJ I-LF -testing NOUN I-LF -( PUNCT B-O -VCT PROPN B-AC -) PUNCT B-O -or CCONJ B-O -provider NOUN B-O -- PUNCT B-O -initiated VERB B-O -testing NOUN B-O -. PUNCT B-O - -Mice NOUN B-O -that PRON B-O -need VERB B-O -to ADP B-O -be AUX B-O -perfused VERB B-O -with ADP B-O -PBS PROPN B-AC -and/or CCONJ B-O -4 NUM B-O -% NOUN B-O -paraformaldehyde NOUN B-LF -( PUNCT B-O -PFA PROPN B-AC -) PUNCT B-O -prior ADV B-O -to ADP B-O -tissue NOUN B-O -harvest NOUN B-O -were AUX B-O -anesthetized VERB B-O -with ADP B-O -a DET B-O -combination NOUN B-O -of ADP B-O -ketamine NOUN B-O -( PUNCT B-O -20 NUM B-O -mg NOUN B-O -/ SYM B-O -kg NOUN B-O -body NOUN B-O -weight NOUN B-O -) PUNCT B-O -and CCONJ B-O -xylazine NOUN B-O -( PUNCT B-O -2 NUM B-O -mg NOUN B-O -/ SYM B-O -kg NOUN B-O -body NOUN B-O -weight NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Mild ADJ B-LF -cognitive ADJ I-LF -impairment NOUN I-LF -( PUNCT B-O -MCI PROPN B-AC -) PUNCT B-O -refers VERB B-O -to ADP B-O -a DET B-O -transitional ADJ B-O -zone NOUN B-O -between ADP B-O -normal ADJ B-O -ageing NOUN B-O -and CCONJ B-O -dementia NOUN B-O -. PUNCT B-O - -Quantitative ADJ B-O -data NOUN B-O -were AUX B-O -to ADP B-O -analyze VERB B-O -completeness NOUN B-O -and CCONJ B-O -timeliness NOUN B-O -of ADP B-O -surveillance NOUN B-O -system NOUN B-O -performance NOUN B-O -from ADP B-O -national ADJ B-O -District PROPN B-LF -Health PROPN I-LF -Information PROPN I-LF -System PROPN I-LF -2 NUM I-LF -( PUNCT B-O -DHIS2 PROPN B-AC -) PUNCT B-O -during ADP B-O -October PROPN B-O -2014 NUM B-O -to ADP B-O -September PROPN B-O -2016 NUM B-O -. PUNCT B-O - -Importantly ADV B-O -, PUNCT B-O -the DET B-O -mice NOUN B-O -are AUX B-O -resistant ADJ B-O -to ADP B-O -the DET B-O -autoimmune ADJ B-O -disease NOUN B-O -models NOUN B-O -collagen NOUN B-O -- PUNCT B-O -induced VERB B-O -arthritis NOUN B-O -and CCONJ B-O -experimental ADJ B-LF -autoimmune ADJ I-LF -encephalomyelitis NOUN I-LF -( PUNCT B-O -EAE PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -20 NUM B-O -] PUNCT B-O -, PUNCT B-O -have VERB B-O -less ADV B-O -aggressive ADJ B-O -Kras PROPN B-O -- PUNCT B-O -induced VERB B-O -inflammatory ADJ B-O -pancreatic ADJ B-O -cancer NOUN B-O -[ PUNCT B-O -21 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -fail VERB B-O -to ADP B-O -mount VERB B-O -an DET B-O -effective ADJ B-O -IL-17A PROPN B-AC -- PUNCT B-O -dependent ADJ B-O -immune ADJ B-O -response NOUN B-O -to ADP B-O -Citrobacter PROPN B-O -rodentium NOUN B-O -infection NOUN B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -surgically ADV B-O -removed VERB B-O -tissue NOUN B-O -was AUX B-O -cut VERB B-O -to PART B-O -smaller ADJ B-O -pieces NOUN B-O -with ADP B-O -scissors NOUN B-O -under ADP B-O -sterile ADJ B-O -conditions NOUN B-O -, PUNCT B-O -and CCONJ B-O -then ADV B-O -incubated VERB B-O -for ADP B-O -15 NUM B-O -min NOUN B-O -at ADP B-O -room NOUN B-LF -temperature NOUN I-LF -( PUNCT B-O -RT PROPN B-AC -) PUNCT B-O -in ADP B-O -dithiothreitol PROPN B-O -: PUNCT B-O -Hank´s PART B-O -balanced ADJ B-O -salt NOUN B-O -solution NOUN B-O -( PUNCT B-O -HBSS PROPN B-O -) PUNCT B-O -( PUNCT B-O -Biosera PROPN B-O -, PUNCT B-O -Nuaille PROPN B-O -, PUNCT B-O -France PROPN B-O -) PUNCT B-O -mix NOUN B-O -( PUNCT B-O -1:9 NUM B-O -v NOUN B-O -/ SYM B-O -v NOUN B-O -) PUNCT B-O -, PUNCT B-O -in ADP B-O -order NOUN B-O -to PART B-O -remove VERB B-O -potential ADJ B-O -contamination NOUN B-O -. PUNCT B-O - -OR PROPN B-AC -, PUNCT B-O -odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -ref NOUN B-O -. PUNCT B-O - -, PUNCT B-O -reference NOUN B-O -; PUNCT B-O -R1 NOUN B-O -, PUNCT B-O -positive ADJ B-O -; PUNCT B-O -R0 NOUN B-O -, PUNCT B-O -negative ADJ B-O -resection NOUN B-O -margins NOUN B-O -Malondialdehyde NOUN B-LF -acetaldehyde NOUN I-LF -- PUNCT B-O -modified VERB B-O -LDL PROPN B-AC -( PUNCT B-O -MAA PROPN B-AC -- PUNCT B-O -LDL PROPN B-AC -) PUNCT B-O -and CCONJ B-O -copper NOUN B-O -- PUNCT B-O -oxidized VERB B-O -LDL PROPN B-AC -( PUNCT B-O -CuOx-LDL PROPN B-AC -) PUNCT B-O -were AUX B-O -prepared VERB B-O -as SCONJ B-O -described VERB B-O -[ PUNCT B-O -21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Then ADV B-O -, PUNCT B-O -the DET B-O -specimens NOUN B-O -were AUX B-O -washed VERB B-O -twice ADV B-O -with ADP B-O -stain NOUN B-O -buffer NOUN B-O -and CCONJ B-O -subsequently ADV B-O -mounted VERB B-O -with ADP B-O -fluoroGel PROPN B-O -mounting NOUN B-O -medium NOUN B-O -( PUNCT B-O -GeneTex PROPN B-O -, PUNCT B-O -Inc PROPN B-O -, PUNCT B-O -Irvine PROPN B-O -, PUNCT B-O -CA PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Stained VERB B-O -specimens NOUN B-O -were AUX B-O -examined VERB B-O -and CCONJ B-O -captured VERB B-O -with ADP B-O -Leica PROPN B-O -TCS PROPN B-O -SPII PROPN B-O -confocal ADJ B-LF -laser NOUN I-LF -scanning VERB I-LF -microscopy NOUN I-LF -system NOUN B-O -( PUNCT B-O -CLSM PROPN B-AC -, PUNCT B-O -; PUNCT B-O -Leica PROPN B-O -Microsystem PROPN B-O -, PUNCT B-O -GmbH PROPN B-O -, PUNCT B-O -Germany PROPN B-O -) PUNCT B-O -with ADP B-O -LAS PROPN B-O -AF PROPN B-O -Lite PROPN B-O -software NOUN B-O -( PUNCT B-O -Leica PROPN B-O -Microsystems PROPN B-O -, PUNCT B-O -Mannheim PROPN B-O -, PUNCT B-O -Germany PROPN B-O -) PUNCT B-O -. PUNCT B-O - -HEK PROPN B-AC -, PUNCT B-O -human ADJ B-LF -embryonic ADJ I-LF -kidney NOUN I-LF -cell NOUN I-LF -; PUNCT B-O -ns PROPN B-O -, PUNCT B-O -not PART B-O -significant ADJ B-O -; PUNCT B-O -WT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -type NOUN I-LF -. PUNCT B-O - -Malondialdehyde NOUN B-LF -( PUNCT B-O -MDA PROPN B-AC -) PUNCT B-O -content NOUN B-O -was AUX B-O -measured VERB B-O -by ADP B-O -the DET B-O -procedures NOUN B-O -described VERB B-O -by ADP B-O -Wang PROPN B-O -et PROPN B-O -al NOUN B-O -. PUNCT B-O - -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Ischaemia NOUN B-O -- PUNCT B-O -reperfusion NOUN B-O -injury NOUN B-O -in ADP B-O -kidney NOUN B-O -transplantation NOUN B-O -leads VERB B-O -to ADP B-O -delayed VERB B-LF -graft NOUN I-LF -function NOUN I-LF -( PUNCT B-O -DGF PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -associated VERB B-O -with ADP B-O -reduced VERB B-O -long ADJ B-O -term NOUN B-O -graft NOUN B-O -function NOUN B-O -. PUNCT B-O - -Opaque NOUN B-O -a DET B-O -and CCONJ B-O -α PUNCT B-O -cells NOUN B-O -secrete VERB B-O -a DET B-O -sex NOUN B-O -- PUNCT B-O -specific ADJ B-O -pheromone NOUN B-O -and CCONJ B-O -induce VERB B-O -the DET B-O -formation NOUN B-O -of ADP B-O -mating NOUN B-O -projections NOUN B-O -in ADP B-O -cells NOUN B-O -with ADP B-O -an DET B-O -opposite ADJ B-O -Mating NOUN B-LF -type NOUN I-LF -locus NOUN I-LF -( PUNCT B-O -MTL PROPN B-AC -) PUNCT B-O -type NOUN B-O -, PUNCT B-O -thus ADV B-O -initiating VERB B-O -cell NOUN B-O -fusion NOUN B-O -and CCONJ B-O -mating NOUN B-O -[ PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Heart NOUN B-LF -rate NOUN I-LF -( PUNCT B-O -HR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -velocity NOUN B-O -, PUNCT B-O -left ADJ B-LF -ventricle NOUN I-LF -( PUNCT B-O -LV PROPN B-AC -) PUNCT B-O -mass NOUN B-O -, PUNCT B-O -LV PROPN B-LF -internal ADJ I-LF -LV PROPN B-AC -diameter NOUN I-LF -at ADP I-LF -end NOUN I-LF -- PUNCT I-LF -diastole NOUN I-LF -( PUNCT B-O -LVID PROPN B-AC -) PUNCT B-O -, PUNCT B-O -LV PROPN B-LF -posterior ADJ I-LF -,dLV PROPN B-AC -wall NOUN I-LF -thickness NOUN I-LF -at ADP I-LF -end NOUN I-LF -- PUNCT I-LF -diastole NOUN I-LF -( PUNCT B-O -LVPW PROPN B-AC -) PUNCT B-O -, PUNCT B-O -LV PROPN B-LF -anterior ADJ I-LF -,dLV PROPN B-AC -wall NOUN I-LF -thickness NOUN I-LF -at ADP I-LF -end NOUN I-LF -- PUNCT I-LF -diastole NOUN I-LF -( PUNCT B-O -LVAW PROPN B-AC -) PUNCT B-O -, PUNCT B-O -ejection NOUN B-LF -fraction NOUN I-LF -( PUNCT B-O -,dEF PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -fractional ADJ B-LF -shortening NOUN I-LF -( PUNCT B-O -FS PROPN B-AC -) PUNCT B-O -of ADP B-O -the DET B-O -LV PROPN B-AC -were AUX B-O -measured VERB B-O -. PUNCT B-O - -The DET B-O -generation NOUN B-O -of ADP B-O -type NOUN B-LF -2 NUM I-LF -( PUNCT B-O -Th2 PROPN B-AC -) PUNCT B-O -cytokines NOUN B-O -, PUNCT B-O -particularly ADV B-O -interleukins NOUN B-LF -( PUNCT B-O -IL)-13 PROPN B-AC -and CCONJ B-O -IL-4 PROPN B-AC -, PUNCT B-O -is AUX B-O -associated VERB B-O -with ADP B-O -parasite NOUN B-O -expulsion NOUN B-O -through ADP B-O -increased VERB B-O -epithelial ADJ B-O -cell NOUN B-O -turnover NOUN B-O -, PUNCT B-O -mucus NOUN B-O -production NOUN B-O -, PUNCT B-O -and CCONJ B-O -muscle NOUN B-O -hypercontractility NOUN B-O -[ PUNCT B-O -28 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Photographs NOUN B-O -showing VERB B-O -double ADJ B-O -- PUNCT B-O -labeling NOUN B-O -for ADP B-O -galanin NOUN B-LF -receptor NOUN I-LF -type NOUN I-LF -2 NUM I-LF -( PUNCT B-O -GalR2 PROPN B-AC -) PUNCT B-O -( PUNCT B-O -A PROPN B-O -, PUNCT B-O -D PROPN B-O -) PUNCT B-O -, PUNCT B-O -NF200 PROPN B-O -( PUNCT B-O -B NOUN B-O -, PUNCT B-O -E NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -merged VERB B-O -images NOUN B-O -( PUNCT B-O -C PROPN B-O -, PUNCT B-O -F PROPN B-O -) PUNCT B-O -in ADP B-O -dorsal ADJ B-LF -root NOUN I-LF -ganglion NOUN I-LF -( PUNCT B-O -DRG PROPN B-AC -) PUNCT B-O -neurons NOUN B-O -of ADP B-O -the DET B-O -naïve ADJ B-O -( PUNCT B-O -A PROPN B-O -- PUNCT B-O -C PROPN B-O -) PUNCT B-O -and CCONJ B-O -chronic ADJ B-O -constriction NOUN B-O -injury NOUN B-O -1 NUM B-O -week NOUN B-O -( PUNCT B-O -CCI1W PROPN B-O -) PUNCT B-O -( PUNCT B-O -D PROPN B-O -- PUNCT B-O -F PROPN B-O -) PUNCT B-O -groups NOUN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -PRS PROPN B-AC -, PUNCT B-O -postreperfusion NOUN B-LF -syndrome NOUN I-LF -; PUNCT B-O -PS PROPN B-O -, PUNCT B-O -propensity NOUN B-O -score NOUN B-O -. PUNCT B-O - -ABR PROPN B-AC -, PUNCT B-O -auditory ADJ B-LF -brainstem NOUN I-LF -response NOUN I-LF -; PUNCT B-O -DFNA PROPN B-O -, PUNCT B-O -non ADJ B-O -- ADJ B-O -syndromic ADJ B-O -deafness NOUN B-O -with ADP B-O -dominant ADJ B-O -inheritance NOUN B-O -; PUNCT B-O -DFNB PROPN B-O -, PUNCT B-O -non ADJ B-O -- ADJ B-O -syndromic ADJ B-O -deafness NOUN B-O -with ADP B-O -recessive ADJ B-O -inheritance NOUN B-O -; PUNCT B-O -DFNX PROPN B-O -, PUNCT B-O -non ADJ B-O -- ADJ B-O -syndromic ADJ B-O -deafness NOUN B-O -with ADP B-O -X NOUN B-O -- ADJ B-O -linked VERB B-O -inheritance NOUN B-O -; PUNCT B-O -Hemi PROPN B-O -, PUNCT B-O -hemizygote NOUN B-O -; PUNCT B-O -Het PROPN B-O -, PUNCT B-O -heterozygote NOUN B-O -; PUNCT B-O -Hom PROPN B-O -, PUNCT B-O -homozygote NOUN B-O -; PUNCT B-O -MGP PROPN B-AC -, PUNCT B-O -Mouse PROPN B-LF -Genetics PROPN I-LF -Project PROPN I-LF -; PUNCT B-O -tm PROPN B-AC -, PUNCT B-O -targeted VERB B-LF -mutation NOUN I-LF -. PUNCT B-O - -Phosphatidylcholine NOUN B-O -( PUNCT B-O -PC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -phosphatidic NOUN B-LF -acid NOUN I-LF -( PUNCT B-O -PA PROPN B-AC -) PUNCT B-O -and CCONJ B-O -cholesterol NOUN B-O -( PUNCT B-O -CH NOUN B-O -) PUNCT B-O -( PUNCT B-O -Avanti PROPN B-O -Polar PROPN B-O -Lipids PROPN B-O -, PUNCT B-O -Alabaster PROPN B-O -, PUNCT B-O -AL PROPN B-O -) PUNCT B-O -were AUX B-O -dissolved VERB B-O -in ADP B-O -chloroform NOUN B-O -under ADP B-O -argon NOUN B-O -, PUNCT B-O -mixed VERB B-O -in ADP B-O -3:1:1 NUM B-O -proportion NOUN B-O -, PUNCT B-O -respectively ADV B-O -( PUNCT B-O -w NOUN B-O -/ SYM B-O -w NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -chloroform NOUN B-O -was AUX B-O -evaporated VERB B-O -. PUNCT B-O - -Prior ADV B-O -to ADP B-O -data NOUN B-O -collection NOUN B-O -, PUNCT B-O -a DET B-O -two NUM B-O -- NOUN B-O -day NOUN B-O -intensive ADJ B-O -training NOUN B-O -was AUX B-O -given VERB B-O -to ADP B-O -data NOUN B-O -collectors NOUN B-O -( PUNCT B-O -physiotherapist NOUN B-O -) PUNCT B-O -by ADP B-O -the DET B-O -principal ADJ B-O -investigator NOUN B-O -( PUNCT B-O -KS PROPN B-O -) PUNCT B-O -and CCONJ B-O -clinical ADJ B-O -neurologist NOUN B-O -of ADP B-O -UOGH PROPN B-O -following VERB B-O -which PRON B-O -a DET B-O -pre NOUN B-O -- NOUN B-O -test NOUN B-O -of ADP B-O -data NOUN B-O -collection NOUN B-O -was AUX B-O -carried VERB B-O -out ADP B-O -with ADP B-O -15 NUM B-O -PLHIV PROPN B-AC -. PUNCT B-O - -Brief ADJ B-O -peripheral ADJ B-O -neuropathy NOUN B-O -screening NOUN B-O -tool NOUN B-O -validated VERB B-O -by ADP B-O -the DET B-O -AIDS PROPN B-LF -Clinical PROPN I-LF -trial PROPN I-LF -Group PROPN I-LF -( PUNCT B-O -ACTG PROPN B-AC -) PUNCT B-O -[ X B-O -20 X B-O -] X B-O -was AUX B-O -administered VERB B-O -by ADP B-O -a DET B-O -trained VERB B-O -physiotherapist NOUN B-O -. PUNCT B-O - -The DET B-O -objective NOUN B-O -of ADP B-O -this DET B-O -study NOUN B-O -was AUX B-O -to ADP B-O -assess VERB B-O -whether SCONJ B-O -SAM PROPN B-AC -treatment NOUN B-O -delivered VERB B-O -by ADP B-O -CHWs PROPN B-AC -close ADJ B-O -to ADP B-O -families NOUN B-O -’ PUNCT B-O -locations NOUN B-O -may AUX B-O -improve VERB B-O -the DET B-O -early ADJ B-O -identification NOUN B-O -of ADP B-O -cases NOUN B-O -compared VERB B-O -to ADP B-O -outpatient NOUN B-O -treatment NOUN B-O -at ADP B-O -health NOUN B-LF -facilities NOUN I-LF -( PUNCT B-O -HFs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -with ADP B-O -a DET B-O -decreased VERB B-O -number NOUN B-O -complicated ADJ B-O -cases NOUN B-O -referred VERB B-O -to ADP B-O -stabilization NOUN B-O -centers NOUN B-O -, PUNCT B-O -increased VERB B-O -anthropometric ADJ B-O -measurements NOUN B-O -at ADP B-O -admission NOUN B-O -( PUNCT B-O -closer ADJ B-O -to ADP B-O -the DET B-O -admission NOUN B-O -threshold NOUN B-O -) PUNCT B-O -and CCONJ B-O -similarity NOUN B-O -in ADP B-O -clinical ADJ B-O -outcomes NOUN B-O -( PUNCT B-O -cure NOUN B-O -, PUNCT B-O -death NOUN B-O -, PUNCT B-O -and CCONJ B-O -default NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Patients NOUN B-O -are AUX B-O -triaged VERB B-O -to ADP B-O -three NUM B-O -sections NOUN B-O -of ADP B-O -the DET B-O -ED PROPN B-AC -( PUNCT B-O -High ADJ B-O -Acuity NOUN B-O -, PUNCT B-O -Low ADJ B-O -Acuity NOUN B-O -and CCONJ B-O -Pediatrics NOUN B-O -) PUNCT B-O -based VERB B-O -on ADP B-O -the DET B-O -Emergency PROPN B-LF -Severity PROPN I-LF -Index PROPN I-LF -( PUNCT B-O -ESI PROPN B-AC -) PUNCT B-O -and CCONJ B-O -age NOUN B-O -. PUNCT B-O - -AP1 PROPN B-AC -, PUNCT B-O -activator NOUN B-LF -protein NOUN I-LF -1 NUM I-LF -; PUNCT B-O -bHLH PROPN B-O -, PUNCT B-O -basic ADJ B-O -helix NOUN B-O -- PUNCT B-O -loop NOUN B-O -- PUNCT B-O -helix NOUN B-O -; PUNCT B-O -ChIP PROPN B-AC -, PUNCT B-O -chromatin NOUN B-LF -immunoprecipitation NOUN I-LF -and CCONJ I-LF -sequencing NOUN I-LF -; PUNCT B-O --SeqdnIκBα PROPN B-AC -, PUNCT B-O -dominant ADJ B-O -negative ADJ B-O -NFKB PROPN B-O -inhibitor NOUN B-O -alpha NOUN B-O -; PUNCT B-O -FDR PROPN B-AC -, PUNCT B-O -false ADJ B-LF -discovery NOUN I-LF -rate NOUN I-LF -; PUNCT B-O -GO PROPN B-AC -, PUNCT B-O -Gene PROPN B-LF -Ontology PROPN I-LF -; PUNCT B-O -NF PROPN B-AC -, PUNCT B-O -nuclear ADJ B-LF -factor NOUN I-LF -kappa NOUN I-LF -B NOUN I-LF -; PUNCT B-O -PPARG PROPN B-O -, PUNCT B-O -peroxisome NOUN B-O -proliferator NOUN B-O -– PUNCT B-O -activated VERB B-O -receptor NOUN B-O -gamma NOUN B-O -; PUNCT B-O --κBRNA PROPN B-AC -, PUNCT B-O -RNA NOUN B-LF -sequencing NOUN I-LF -; PUNCT B-O -SOX8 PROPN B-O -, PUNCT B-O -SRY NOUN B-O -- PUNCT B-O -box NOUN B-O -8 NUM B-O -; PUNCT B-O --SeqTet PROPN B-AC -, PUNCT B-O -tetracycline NOUN B-LF -. PUNCT B-O - -Antibodies NOUN B-O -were AUX B-O -used VERB B-O -at ADP B-O -dilutions NOUN B-O -recommended VERB B-O -by ADP B-O -the DET B-O -manufacturers NOUN B-O -. PUNCT B-O - -1 NUM B-O -- PUNCT B-O -methyl-4 NOUN B-O -- PUNCT B-O -phenylpyridinium NOUN B-O -( PUNCT B-O -MPP+ NOUN B-O -) PUNCT B-O -, PUNCT B-O -adenosine NOUN B-LF -- PUNCT I-LF -triphosphate NOUN I-LF -( PUNCT B-O -ATP PROPN B-AC -) PUNCT B-O -were AUX B-O -obtained VERB B-O -from ADP B-O -Sigma PROPN B-O -- PUNCT B-O -Aldrich PROPN B-O -. PUNCT B-O - -Another DET B-O -example NOUN B-O -is AUX B-O -the DET B-O -World PROPN B-O -Bank PROPN B-O -and CCONJ B-O -UNICEF PROPN B-O -– PUNCT B-O -funded VERB B-O -Child PROPN B-LF -Survival PROPN I-LF -and CCONJ I-LF -Safe PROPN I-LF -Motherhood PROPN I-LF -( PUNCT B-O -CSSM PROPN B-AC -) PUNCT B-O -Program PROPN B-O -, PUNCT B-O -which PRON B-O -was AUX B-O -implemented VERB B-O -from ADP B-O -1992–93 NUM B-O -to ADP B-O -1997–98 NUM B-O -and CCONJ B-O -later ADV B-O -merged VERB B-O -into ADP B-O -the DET B-O -Reproductive PROPN B-LF -and CCONJ I-LF -Child PROPN I-LF -Health PROPN I-LF -( PUNCT B-O -RCH PROPN B-AC -) PUNCT B-O -program NOUN B-O -in ADP B-O -1997–98 NUM B-O -( PUNCT B-O -http://mohfw.nic.in/dofw%20website/Child%20healthrti.pdf X B-O -) PUNCT B-O -. PUNCT B-O - -Following VERB B-O -24 NUM B-O -h NOUN B-O -to ADP B-O -48h NUM B-O -of ADP B-O -transfection NOUN B-O -( PUNCT B-O -Lipofectamine PROPN B-O -2000 NUM B-O -, PUNCT B-O -Invitrogen PROPN B-O -) PUNCT B-O -of ADP B-O -3μg ADP B-O -of ADP B-O -expression NOUN B-O -plasmid(s NOUN B-O -) PUNCT B-O -, PUNCT B-O -100 NUM B-O -mm NOUN B-O -diameter NOUN B-O -plates NOUN B-O -of ADP B-O -HEK293 NOUN B-O -T NOUN B-O -cells NOUN B-O -were AUX B-O -washed VERB B-O -in ADP B-O -cold ADJ B-O -PBS PROPN B-O -, PUNCT B-O -lysed VERB B-O -in ADP B-O -1ml NUM B-O -of ADP B-O -TX100 PROPN B-AC -lysis NOUN B-O -buffer NOUN B-O -containing VERB B-O -Tris PROPN B-O -50mM PROPN B-O -PH:7.5 NUM B-O -, PUNCT B-O -NaCl PROPN B-O -150 NUM B-O -mM NOUN B-O -1 NUM B-O -% NOUN B-O -of ADP B-O -Triton PROPN B-LF -X100 NUM I-LF -and CCONJ B-O -a DET B-O -complete ADJ B-O -protease NOUN B-O -inhibitor NOUN B-O -cocktail NOUN B-O -( PUNCT B-O -Roche PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Baseline ADJ B-O -categorical ADJ B-O -data NOUN B-O -are AUX B-O -presented VERB B-O -as ADP B-O -frequency NOUN B-O -( PUNCT B-O -percent NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -continuous ADJ B-O -data NOUN B-O -are AUX B-O -presented VERB B-O -as ADP B-O -median NOUN B-O -( PUNCT B-O -interquartile ADJ B-LF -range NOUN I-LF -[ X B-O -IQR PROPN B-AC -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -the DET B-O -present ADJ B-O -study NOUN B-O -, PUNCT B-O -we PRON B-O -have AUX B-O -examined VERB B-O -the DET B-O -possibility NOUN B-O -that SCONJ B-O -the DET B-O -Fat1 PROPN B-AC -cadherin NOUN B-O -, PUNCT B-O -a DET B-O -planar NOUN B-LF -cell NOUN I-LF -polarity NOUN I-LF -( PUNCT B-O -PCP PROPN B-AC -) PUNCT B-O -molecule NOUN B-O -involved VERB B-O -in ADP B-O -tissue NOUN B-O -morphogenesis NOUN B-O -, PUNCT B-O -could AUX B-O -contribute VERB B-O -to PART B-O -coordinate NOUN B-O -muscular ADJ B-O -and CCONJ B-O -neuronal ADJ B-O -morphogenesis NOUN B-O -. PUNCT B-O - -TheRe PROPN B-AC -is AUX B-O -calculated VERB B-O -by ADP B-O -: PUNCT B-O -Re PROPN B-AC -= ADP B-O -uwdbνw(18 NUM B-O -) PUNCT B-O -where SCONJ B-O -uw PROPN B-AC -( PUNCT B-O -m PROPN B-AC -/ NOUN B-O -s PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -velocity NOUN B-O -of ADP B-O -water NOUN B-O -, PUNCT B-O -db PROPN B-AC -( PUNCT B-O -m PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -diameter NOUN B-O -of ADP B-O -heat NOUN B-O -exchange NOUN B-O -borehole NOUN B-O -, PUNCT B-O -and CCONJ B-O -νw PROPN B-AC -( PUNCT B-O -m2 PROPN B-AC -/ NOUN B-O -s PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -dynamic ADJ B-LF -viscosity NOUN I-LF -of ADP I-LF -water NOUN I-LF -. PUNCT B-O - -Similarly ADV B-O -, PUNCT B-O -this DET B-O -study NOUN B-O -found VERB B-O -HIV PROPN B-AC -testing NOUN B-O -as SCONJ B-O -part NOUN B-O -of ADP B-O -the DET B-O -requirements NOUN B-O -of ADP B-O -focused VERB B-O -antenatal ADJ B-LF -care NOUN I-LF -package NOUN B-O -to PART B-O -be AUX B-O -a DET B-O -barrier NOUN B-O -for SCONJ B-O -both DET B-O -men NOUN B-O -and CCONJ B-O -women NOUN B-O -to PART B-O -attend VERB B-O -at ADP B-O -ANC PROPN B-AC -. PUNCT B-O - -It PRON B-O -was AUX B-O -noted VERB B-O -that SCONJ B-O -men NOUN B-O -felt VERB B-O -obligated ADJ B-O -to PART B-O -attend VERB B-O -ANC PROPN B-AC -with ADP B-O -their PRON B-O -partners NOUN B-O -on ADP B-O -the DET B-O -first ADJ B-O -ANC PROPN B-AC -visit NOUN B-O -so SCONJ B-O -that SCONJ B-O -their PRON B-O -partners NOUN B-O -may AUX B-O -not PART B-O -be AUX B-O -denied VERB B-O -services NOUN B-O -when SCONJ B-O -unaccompanied ADJ B-O -, PUNCT B-O -even ADV B-O -as SCONJ B-O -some PRON B-O -dreaded VERB B-O -HIV PROPN B-AC -testing NOUN B-O -. PUNCT B-O - -As SCONJ B-O -the DET B-O -Thai ADJ B-O -Ministry PROPN B-LF -of ADP I-LF -Public PROPN I-LF -Health PROPN I-LF -( PUNCT B-O -MoPH PROPN B-AC -) NOUN B-O -policy NOUN B-O -requires VERB B-O -insecticide NOUN B-O -spraying NOUN B-O -both CCONJ B-O -upon SCONJ B-O -identification NOUN B-O -of ADP B-O -a DET B-O -dengue NOUN B-O -case NOUN B-O -and CCONJ B-O -7 NUM B-O -d NOUN B-O -later ADV B-O -, NOUN B-O -the DET B-O -study NOUN B-O -team NOUN B-O -provided VERB B-O -the DET B-O -initial ADJ B-O -spraying NOUN B-O -and CCONJ B-O -the DET B-O -Thai ADJ B-O -MoPH PROPN B-AC -provided VERB B-O -the DET B-O -day NOUN B-O -7 NUM B-O -spraying NOUN B-O -( PUNCT B-O -deltamethrin NOUN B-O -or CCONJ B-O -permethrin NOUN B-O -10 NUM B-O -% NOUN B-O -) NOUN B-O -, NOUN B-O -regardless ADV B-O -of ADP B-O -the DET B-O -dengue NOUN B-O -PCR PROPN B-AC -status NOUN B-O -of ADP B-O -the DET B-O -index NOUN B-O -case NOUN B-O -for ADP B-O -that DET B-O -cluster NOUN B-O -. PUNCT B-O - -EM PROPN B-O -, PUNCT B-O -electron NOUN B-O -microscopy NOUN B-O -; PUNCT B-O -Fab PROPN B-AC -, PUNCT B-O -fragment NOUN B-LF -antigen NOUN I-LF -binding VERB I-LF -; PUNCT B-O -HA PROPN B-AC -, PUNCT B-O -hemagglutinin NOUN B-LF -; PUNCT B-O -nsEM PROPN B-AC -, PUNCT B-O -negative ADJ B-O -- PUNCT B-O -stain NOUN B-O -EM PROPN B-O -; PUNCT B-O -PDB PROPN B-AC -, PUNCT B-O -Protein PROPN B-LF -Data PROPN I-LF -Bank PROPN I-LF -. PUNCT B-O - -FI PROPN B-AC -, PUNCT B-O -RpfF NOUN B-LF -interaction NOUN I-LF -RpfF PROPN B-AC -; PUNCT B-O -PAS PROPN B-AC -, PUNCT B-O -Per PROPN B-LF -- PUNCT I-LF -Arnt PROPN I-LF -- PUNCT I-LF -Sim PROPN I-LF -; PUNCT B-O -RpfF PROPN B-AC -, PUNCT B-O -regulation NOUN B-LF -of ADP I-LF -pathogenicity NOUN I-LF -factor NOUN I-LF -F PROPN I-LF -; PUNCT B-O -RpfR PROPN B-AC -, PUNCT B-O -regulation NOUN B-LF -of ADP I-LF -pathogenicity NOUN I-LF -factor NOUN I-LF -R NOUN I-LF -; PUNCT B-O -SUMO PROPN B-AC -, PUNCT B-O -small ADJ B-LF -ubiquitin NOUN I-LF -- PUNCT I-LF -like ADJ I-LF -modifier NOUN I-LF -. PUNCT B-O - -Effect NOUN B-O -of ADP B-O -non ADJ B-O -- ADJ B-O -Darcy ADJ B-O -flow NOUN B-O -can AUX B-O -be PROPN B-AC -considered VERB B-O -by ADP B-O -adjusting VERB B-O -the DET B-O -slip NOUN B-LF -coefficient NOUN I-LF -which PRON B-O -appereas VERB B-O -in ADP B-O -Eq NOUN B-O -( PUNCT B-O -30 NUM B-O -) PUNCT B-O -. PUNCT B-O - -To PART B-O -observe VERB B-O -the DET B-O -location NOUN B-O -of ADP B-O -P. PROPN B-O -berghei PROPN B-O -proteins NOUN B-O -, PUNCT B-O -the DET B-O -C NOUN B-O -- PUNCT B-O -terminus NOUN B-O -of ADP B-O -the DET B-O -gene NOUN B-O -was AUX B-O -tagged VERB B-O -with ADP B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -GFP PROPN B-AC -) PUNCT B-O -sequence NOUN B-O -by ADP B-O -single ADJ B-O -crossover NOUN B-O -homologous ADJ B-O -recombination NOUN B-O -. PUNCT B-O - -Gestational ADJ B-LF -diabetes NOUN I-LF -mellitus NOUN I-LF -( PUNCT B-O -GDM PROPN B-AC -) PUNCT B-O -is AUX B-O -defined VERB B-O -as ADP B-O -any DET B-O -degree NOUN B-O -of ADP B-O -glucose NOUN B-O -intolerance NOUN B-O -with ADP B-O -onset NOUN B-O -or CCONJ B-O -first ADJ B-O -recognition NOUN B-O -during ADP B-O -pregnancy NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Furthermore ADV B-O -induction NOUN B-O -of ADP B-O -diabetes NOUN B-O -type NOUN B-O -1 NUM B-O -induced VERB B-O -a DET B-O -decrease NOUN B-O -in ADP B-O -major ADJ B-O -angiogenic ADJ B-O -growth NOUN B-O -factor NOUN B-O -in ADP B-O -the DET B-O -skeletal ADJ B-O -muscle NOUN B-O -capillary ADJ B-O -bed NOUN B-O -of ADP B-O -mice.[6 NOUN B-O -] PUNCT B-O -In ADP B-O -a DET B-O -chicken NOUN B-O -model NOUN B-O -of ADP B-O -neoangiogenesis NOUN B-O -, PUNCT B-O -hyperglycemia NOUN B-O -was AUX B-O -shown VERB B-O -to ADP B-O -impair VERB B-O -angiogenesis NOUN B-O -through ADP B-O -induction NOUN B-O -of ADP B-O -apoptosis NOUN B-O -and CCONJ B-O -decreases VERB B-O -proliferation NOUN B-O -of ADP B-O -endothelial ADJ B-O -cells.[7 NOUN B-O -] PUNCT B-O -In ADP B-O -a DET B-O -diabetic ADJ B-O -mouse NOUN B-O -model NOUN B-O -with ADP B-O -hindlimb NOUN B-O -- ADJ B-O -induced VERB B-O -ischemia NOUN B-O -, PUNCT B-O -restoration NOUN B-O -of ADP B-O -perfusion NOUN B-O -in ADP B-O -the DET B-O -ischemic ADJ B-O -limb NOUN B-O -was AUX B-O -impaired VERB B-O -and CCONJ B-O -capillary ADJ B-O -density NOUN B-O -reduced.[8 VERB B-O -] PUNCT B-O -Goligorsky PROPN B-O -and CCONJ B-O -colleagues NOUN B-O -demonstrated VERB B-O -an DET B-O -angiogenic ADJ B-O -switch NOUN B-O -during ADP B-O -natural ADJ B-O -history NOUN B-O -of ADP B-O -type NOUN B-LF -2 NUM I-LF -diabetes NOUN I-LF -mellitus NOUN I-LF -( PUNCT B-O -T2DM PROPN B-AC -) PUNCT B-O -from ADP B-O -pro ADJ B-O -- ADJ B-O -angiogenic ADJ B-O -phenotype NOUN B-O -at ADP B-O -the DET B-O -early ADJ B-O -pre ADJ B-O -- ADJ B-O -diabetic ADJ B-O -stages NOUN B-O -to ADP B-O -the DET B-O -profound ADJ B-O -inhibition NOUN B-O -of ADP B-O -ex ADJ B-O -- ADJ B-O -vivo ADJ B-O -angiogenesis NOUN B-O -and CCONJ B-O -microvascular ADJ B-O -rarefaction NOUN B-O -in ADP B-O -the DET B-O -kidneys NOUN B-O -of ADP B-O -obese ADJ B-O -zucker PROPN B-O -diabetic ADJ B-O -fat ADJ B-O -rats.[5 NOUN B-O -] PUNCT B-O -Peritubular ADJ B-O -capillary ADJ B-O -rarefaction NOUN B-O -is VERB B-O -a DET B-O -major ADJ B-O -hallmark NOUN B-O -of ADP B-O -chronic ADJ B-O -kidney NOUN B-O -disease NOUN B-O -and CCONJ B-O -predicts VERB B-O -renal ADJ B-O -outcome NOUN B-O -in ADP B-O -diabetic ADJ B-O -nephropathy.[9 NOUN B-O -] PUNCT B-O -There PRON B-O -is VERB B-O -evidence NOUN B-O -from ADP B-O -animal NOUN B-O -models NOUN B-O -that SCONJ B-O -endothelial ADJ B-O -dysfunction NOUN B-O -, PUNCT B-O -oxidative ADJ B-O -stress NOUN B-O -, PUNCT B-O -interstitial ADJ B-O -hypoxia NOUN B-O -due ADP B-O -to ADP B-O -arteriolar ADJ B-O -vasoconstriction NOUN B-O -and CCONJ B-O -pericyte NOUN B-O -detachment NOUN B-O -from ADP B-O -the DET B-O -vasculature NOUN B-O -are AUX B-O -involved VERB B-O -in ADP B-O -this DET B-O -pathophysiological ADJ B-O -process.[9 NOUN B-O -] PUNCT B-O -Initially ADV B-O -thought VERB B-O -to PART B-O -be AUX B-O -absent ADJ B-O -in ADP B-O -mammals NOUN B-O -, PUNCT B-O -small ADJ B-O -quantities NOUN B-O -of ADP B-O -α PUNCT B-O -- PUNCT B-O -linked VERB B-O -monoglycosylceramides NOUN B-O -( PUNCT B-O -e.g. X B-O -, PUNCT B-O -α PUNCT B-LF -- PUNCT I-LF -galactosylceramide NOUN I-LF -[ PUNCT B-O -α-GalCer PROPN B-AC -] PUNCT B-O -) PUNCT B-O -that PRON B-O -may AUX B-O -act VERB B-O -as ADP B-O -iNKT PROPN B-AC -cell NOUN B-O -self NOUN B-O -- PUNCT B-O -Ags PROPN B-AC -have AUX B-O -been AUX B-O -identified VERB B-O -[ PUNCT B-O -14 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -effect NOUN B-O -size NOUN B-O -for ADP B-O -the DET B-O -primary ADJ B-O -and CCONJ B-O -secondary ADJ B-O -outcomes NOUN B-O -was AUX B-O -evaluated VERB B-O -as ADP B-O -the DET B-O -standardized ADJ B-LF -mean NOUN I-LF -difference NOUN I-LF -( PUNCT B-O -SMD PROPN B-AC -) PUNCT B-O -in ADP B-O -testing VERB B-O -frequency NOUN B-O -between ADP B-O -intervention NOUN B-O -and CCONJ B-O -control NOUN B-O -arms NOUN B-O -. PUNCT B-O - -Activation NOUN B-O -of ADP B-O -MET PROPN B-AC -signaling NOUN B-O -cascade NOUN B-O -by ADP B-O -its PRON B-O -ligand NOUN B-O -HGF PROPN B-O -results VERB B-O -in ADP B-O -colony NOUN B-O -dispersal NOUN B-O -, PUNCT B-O -epithelial ADJ B-LF -- PUNCT I-LF -mesenchymal NOUN I-LF -transition NOUN I-LF -( PUNCT B-O -EMT PROPN B-AC -) PUNCT B-O -and CCONJ B-O -increased VERB B-O -motility NOUN B-O -[ PUNCT B-O -40 NUM B-O -] PUNCT B-O -. PUNCT B-O - -When SCONJ B-O -DCs PROPN B-AC -mature VERB B-O -, PUNCT B-O -they PRON B-O -synthesize VERB B-O -high ADJ B-O -levels NOUN B-O -of ADP B-O -NO PROPN B-AC -, PUNCT B-O -interleukin NOUN B-LF -( PUNCT B-O -IL PROPN B-AC -) PUNCT B-O -12 NUM B-O -, PUNCT B-O -and CCONJ B-O -RANTES PROPN B-AC -, PUNCT B-O -and CCONJ B-O -express VERB B-O -more ADV B-O -costimulatory ADJ B-O -molecules NOUN B-O -such ADJ B-O -as ADP B-O -CD86 PROPN B-O -and CCONJ B-O -major ADJ B-LF -histocompatibility NOUN I-LF -complex NOUN I-LF -( PUNCT B-O -MHC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -all PRON B-O -of ADP B-O -which PRON B-O -can AUX B-O -induce VERB B-O -T NOUN B-O -cells NOUN B-O -to ADP B-O -become VERB B-O -fully ADV B-O -activated ADJ B-O -to ADP B-O -initial ADJ B-O -immune ADJ B-O -response NOUN B-O -[ PUNCT B-O -19 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Clot NOUN B-O -formation NOUN B-O -inside ADP B-O -one NUM B-O -of ADP B-O -the DET B-O -veins NOUN B-O -deep ADJ B-O -in ADP B-O -the DET B-O -body NOUN B-O -( PUNCT B-O -usually ADV B-O -in ADP B-O -a DET B-O -leg NOUN B-O -) PUNCT B-O -is AUX B-O -called VERB B-O -deep ADJ B-LF -vein NOUN I-LF -thrombosis NOUN I-LF -( PUNCT B-O -DVT PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -DVT PROPN B-AC -, PUNCT B-O -which PRON B-O -can AUX B-O -cause VERB B-O -pain NOUN B-O -, PUNCT B-O -swelling NOUN B-O -, PUNCT B-O -and CCONJ B-O -redness NOUN B-O -in ADP B-O -the DET B-O -affected VERB B-O -limb NOUN B-O -, PUNCT B-O -is AUX B-O -treated VERB B-O -with ADP B-O -anticoagulants NOUN B-O -, PUNCT B-O -drugs NOUN B-O -that PRON B-O -stop VERB B-O -the DET B-O -clot NOUN B-O -growing VERB B-O -. PUNCT B-O - -This DET B-O -complex NOUN B-O -is AUX B-O -mainly ADV B-O -composed VERB B-O -of ADP B-O -four NUM B-O -subunits NOUN B-O -: PUNCT B-O -a DET B-O -heterodimer NOUN B-O -of ADP B-O -two NUM B-O -structural ADJ B-LF -maintenance NOUN I-LF -of ADP I-LF -chromosome NOUN I-LF -proteins NOUN I-LF -( PUNCT B-O -SMC1 PROPN B-O -and CCONJ B-O -SMC3 PROPN B-O -) PUNCT B-O -, PUNCT B-O -associated VERB B-O -with ADP B-O -two NUM B-O -non ADJ B-O -- ADJ B-O -SMC PROPN B-AC -components NOUN B-O -corresponding VERB B-O -to ADP B-O -sister NOUN B-O -chromatid NOUN B-O -cohesion NOUN B-O -proteins NOUN B-O -( PUNCT B-O -SCC1 PROPN B-O -and CCONJ B-O -SCC3 PROPN B-O -) PUNCT B-O -[ X B-O -3–6 NUM B-O -] PUNCT B-O -; PUNCT B-O -and CCONJ B-O -for ADP B-O -review NOUN B-O -see VERB B-O -[ X B-O -7,8 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Using VERB B-O -liquid NOUN B-LF -chromatography NOUN I-LF -high ADJ I-LF -- PUNCT I-LF -resolution NOUN I-LF -mass NOUN I-LF -spectrometry NOUN I-LF -( PUNCT B-O -LC-HR-MS/MS PROPN B-AC -) PUNCT B-O -analysis NOUN B-O -, PUNCT B-O -we PRON B-O -discovered VERB B-O -1,360 NUM B-O -differentially ADV B-O -expressed VERB B-O -proteins NOUN B-O -in ADP B-O -CLL PROPN B-AC -patients NOUN B-O -compared VERB B-O -to PART B-O -healthy ADJ B-O -donors NOUN B-O -, PUNCT B-O -several ADJ B-O -of ADP B-O -which PRON B-O -had AUX B-O -been AUX B-O -previously ADV B-O -reported VERB B-O -to PART B-O -be AUX B-O -associated VERB B-O -with ADP B-O -cancer NOUN B-O -, PUNCT B-O -yet CCONJ B-O -four NUM B-O -of ADP B-O -which PRON B-O -were AUX B-O -identified VERB B-O -as ADP B-O -being AUX B-O -associated VERB B-O -with ADP B-O -any DET B-O -cancer NOUN B-O -, PUNCT B-O -including VERB B-O -CLL PROPN B-AC -, PUNCT B-O -for ADP B-O -the DET B-O -first ADJ B-O -time NOUN B-O -. PUNCT B-O - -Similar ADJ B-O -improvements NOUN B-O -in ADP B-O -systolic ADJ B-O -and CCONJ B-O -diastolic ADJ B-O -BP PROPN B-AC -to ADP B-O -those PRON B-O -observed VERB B-O -in ADP B-O -this DET B-O -trial NOUN B-O -of ADP B-O -3.3 NUM B-O -and CCONJ B-O -1.4 NUM B-O -mmHg NOUN B-O -were AUX B-O -reported VERB B-O -in ADP B-O -the DET B-O -Heart PROPN B-LF -Outcome PROPN I-LF -Prevention PROPN I-LF -Evaluation PROPN I-LF -( PUNCT B-O -HOPE PROPN B-AC -) PUNCT B-O -study NOUN B-O -and CCONJ B-O -were AUX B-O -associated VERB B-O -with ADP B-O -a DET B-O -22 NUM B-O -% NOUN B-O -reduction NOUN B-O -in ADP B-O -relative ADJ B-O -risk NOUN B-O -of ADP B-O -cardiovascular ADJ B-O -mortality NOUN B-O -, PUNCT B-O -myocardial ADJ B-O -infarction NOUN B-O -, PUNCT B-O -or CCONJ B-O -stroke NOUN B-O -[ PUNCT B-O -23 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -expression NOUN B-O -of ADP B-O -the DET B-O -major ADJ B-O -inflammatory ADJ B-O -cytokines NOUN B-O -, PUNCT B-O -IL-6 PROPN B-AC -, PUNCT B-O -IL-1β NOUN B-O -and CCONJ B-O -TNF PROPN B-AC -, PUNCT B-O -in ADP B-O -spinal ADJ B-O -cords NOUN B-O -of ADP B-O -these DET B-O -SOD1 NOUN B-O -transgenic ADJ B-LF -( PUNCT B-O --αTG PROPN B-AC -) PUNCT B-O -mice NOUN B-O -were AUX B-O -assessed VERB B-O -by ADP B-O -real ADJ B-O -time NOUN B-O -PCR NOUN B-O -. PUNCT B-O - -Mice NOUN B-O -were AUX B-O -then ADV B-O -crossed VERB B-O -with ADP B-O -IL-6(-/- PROPN B-AC -) PUNCT B-O -mice NOUN B-O -to PART B-O -generate VERB B-O -SOD1TG NOUN B-O -/ SYM B-O -IL-6(-/- PROPN B-AC -) PUNCT B-O -mice NOUN B-O -. PUNCT B-O - -In ADP B-O -female ADJ B-O -mouse NOUN B-LF -embryo NOUN I-LF -fibroblasts NOUN I-LF -( PUNCT B-O -MEFs PROPN B-AC -) PUNCT B-O -exhibiting VERB B-O -DD NOUN B-O -signals NOUN B-O -for ADP B-O -Pgk1 NOUN B-O -, PUNCT B-O -the DET B-O -distribution NOUN B-O -of ADP B-O -D PROPN B-AC -/ SYM B-O -D PROPN B-AC -intensity NOUN B-O -ratios NOUN B-O -centered VERB B-O -around ADP B-O -1 NUM B-O -( PUNCT B-O -Figure PROPN B-O -1E NUM B-O -) PUNCT B-O -, PUNCT B-O -demonstrating VERB B-O -that SCONJ B-O -two NUM B-O -replicated VERB B-O -alleles NOUN B-O -display VERB B-O -equal ADJ B-O -signal NOUN B-O -intensities NOUN B-O -. PUNCT B-O - -There PRON B-O -is VERB B-O -no DET B-O -dignity NOUN B-O -… PUNCT B-O -. PUNCT B-O - -” PUNCT B-O -Account NOUN B-O -told VERB B-O -by ADP B-O -a DET B-O -16 NUM B-O -- PUNCT B-O -year NOUN B-O -- PUNCT B-O -old ADJ B-O -Sudanese ADJ B-O -boy NOUN B-O -to ADP B-O -Médecins PROPN B-LF -Sans PROPN I-LF -Frontières PROPN I-LF -( PUNCT B-O -MSF PROPN B-AC -) PUNCT B-O -staff NOUN B-O -, PUNCT B-O -after ADP B-O -being AUX B-O -rescued VERB B-O -on ADP B-O -the DET B-O -Mediterranean PROPN B-O -Sea PROPN B-O -in ADP B-O -August PROPN B-O -2019 NUM B-O -. PUNCT B-O - -To PART B-O -examine VERB B-O -and CCONJ B-O -compare VERB B-O -changes NOUN B-O -in ADP B-O -strength NOUN B-O -and CCONJ B-O -physical ADJ B-O -function NOUN B-O -from ADP B-O -pre- ADJ B-O -to ADP B-O -post ADJ B-O -- ADJ B-O -diagnosis NOUN B-O -among ADP B-O -men NOUN B-O -with ADP B-O -prostate NOUN B-LF -cancer ADJ I-LF -( PUNCT B-O -PC PROPN B-AC -, PUNCT B-O -[ X B-O -cases NOUN B-O -] PUNCT B-O -) PUNCT B-O -and CCONJ B-O -matched VERB B-O -non ADJ B-O -- ADJ B-O -cancer ADJ B-O -controls NOUN B-O -identified VERB B-O -from ADP B-O -the DET B-O -Health PROPN B-O -, PUNCT B-O -Aging PROPN B-O -and CCONJ B-O -Body PROPN B-O -Composition PROPN B-O -( PUNCT B-O -HealthABC PROPN B-AC -) PUNCT B-O -study NOUN B-O -. PUNCT B-O - -The DET B-O -specific ADJ B-O -expression NOUN B-O -of ADP B-O -desatF NOUN B-O -in ADP B-O -D. PROPN B-O -melanogaster NOUN B-O -females NOUN B-O -was AUX B-O -due ADJ B-O -to ADP B-O -a DET B-O -special ADJ B-O -cis ADJ B-LF -- PUNCT I-LF -regulatory ADJ I-LF -element NOUN I-LF -( PUNCT B-O -CRE PROPN B-AC -) PUNCT B-O -located VERB B-O -upstream ADV B-O -of ADP B-O -desatF NOUN B-O -in ADP B-O -D. PROPN B-O -melanogaster NOUN B-O -; PUNCT B-O -the DET B-O -CRE PROPN B-AC -presented VERB B-O -a DET B-O -doublesex PROPN B-O -protein NOUN B-O -( PUNCT B-O -Doublesx PROPN B-LF -, PUNCT B-O -Dsx PROPN B-AC -) PUNCT B-O -binding NOUN B-O -site NOUN B-O -that PRON B-O -could AUX B-O -be AUX B-O -recognized VERB B-O -by ADP B-O -the DET B-O -female NOUN B-O -- PUNCT B-O -specific ADJ B-O -isoform NOUN B-O -of ADP B-O -Dsx PROPN B-AC -( PUNCT B-O -Dsx PROPN B-AC -- PUNCT B-O -F PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -binding NOUN B-O -of ADP B-O -Dsx PROPN B-AC -- PUNCT B-O -F PROPN B-O -activated VERB B-O -the DET B-O -transcription NOUN B-O -of ADP B-O -desatF NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -male NOUN B-O -- PUNCT B-O -specific ADJ B-O -Dsx PROPN B-AC -showed VERB B-O -no DET B-O -regulatory ADJ B-O -activity NOUN B-O -, PUNCT B-O -resulting VERB B-O -in ADP B-O -sexual ADJ B-O -dimorphism NOUN B-O -of ADP B-O -desatF NOUN B-O -expression NOUN B-O -[ PUNCT B-O -42 NUM B-O -] PUNCT B-O -. PUNCT B-O - -DEG PROPN B-AC -, PUNCT B-O -differentially ADV B-LF -expressed VERB I-LF -gene NOUN I-LF -; PUNCT B-O -IL-4 PROPN B-AC -, PUNCT B-O -interleukin-4 NOUN B-LF -. PUNCT B-O - -This PRON B-O -included VERB B-O -the DET B-O -integration NOUN B-O -of ADP B-O -principles NOUN B-O -from ADP B-O -Self PROPN B-LF -- PUNCT I-LF -Determination PROPN I-LF -Theory PROPN I-LF -( PUNCT B-O -SDT PROPN B-AC -) PUNCT B-O -as ADP B-O -a DET B-O -means NOUN B-O -to PART B-O -strengthen VERB B-O -the DET B-O -quality NOUN B-O -, PUNCT B-O -quantity NOUN B-O -, PUNCT B-O -and CCONJ B-O -longevity NOUN B-O -of ADP B-O -motivation NOUN B-O -to PART B-O -change VERB B-O -health NOUN B-O -behaviours NOUN B-O -[ PUNCT B-O -25 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -PAM2 PROPN B-O -Off PROPN B-O -- PUNCT B-O -Target NOUN B-O -# NOUN B-O -2 NUM B-O -template NOUN B-O -( PUNCT B-O -accession NOUN B-O -XM_021073251.1 NOUN B-O -) PUNCT B-O -is AUX B-O -predicted VERB B-O -to ADP B-O -encode VERB B-O -for ADP B-O -an DET B-O -mRNA NOUN B-O -transcript NOUN B-O -for ADP B-O -aminoadipate NOUN B-LF -aminotransferase NOUN I-LF -( PUNCT B-O -AADAT PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -AADAT PROPN B-AC -is AUX B-O -an DET B-O -enzyme NOUN B-O -found VERB B-O -primarily ADV B-O -in ADP B-O -the DET B-O -brain NOUN B-O -and CCONJ B-O -known VERB B-O -to ADP B-O -catalyze VERB B-O -the DET B-O -transamination NOUN B-O -of ADP B-O -kynurenine NOUN B-O -to ADP B-O -kynurenic NOUN B-O -acid NOUN B-O -; PUNCT B-O -AADAT PROPN B-AC -is AUX B-O -also ADV B-O -responsible ADJ B-O -for ADP B-O -the DET B-O -transamination NOUN B-O -of ADP B-O -aminoapidate NOUN B-O -to ADP B-O -alpha NOUN B-O -- PUNCT B-O -oxoadipate[17 NOUN B-O -] PUNCT B-O -. PUNCT B-O - -DIC PROPN B-AC -, PUNCT B-O -differential ADJ B-LF -interference NOUN I-LF -contrast NOUN I-LF -; PUNCT B-O -EXP1 PROPN B-AC -, PUNCT B-O -exported VERB B-LF -protein NOUN I-LF -1 NUM I-LF -; PUNCT B-O -HA PROPN B-O -, PUNCT B-O -triple ADJ B-O -hemagglutinin NOUN B-O -tag NOUN B-O -; PUNCT B-O -KAHRP PROPN B-AC -, PUNCT B-O -knob NOUN B-LF -- PUNCT I-LF -associated VERB I-LF -histidine NOUN I-LF -- PUNCT I-LF -rich ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -pA NOUN B-O -, PUNCT B-O -Picoampere NOUN B-O -; PUNCT B-O -PSAC PROPN B-AC -, PUNCT B-O -parasite NOUN B-LF -surface NOUN I-LF -anion NOUN I-LF -channel NOUN I-LF -; PUNCT B-O -PVM PROPN B-AC -, PUNCT B-O -parasitophorous ADJ B-LF -vacuolar ADJ I-LF -membrane NOUN I-LF -; PUNCT B-O -RBC PROPN B-AC -, PUNCT B-O -red ADJ B-LF -blood NOUN I-LF -cell NOUN I-LF -; PUNCT B-O -SBP1 PROPN B-AC -, PUNCT B-O -skeleton NOUN B-LF -binding VERB I-LF -protein NOUN I-LF -1 NUM I-LF -. PUNCT B-O - -However ADV B-O -, PUNCT B-O -insufficient ADJ B-O -information NOUN B-O -is AUX B-O -available ADJ B-O -on ADP B-O -the DET B-O -effects NOUN B-O -of ADP B-O -fluoride NOUN B-O -on ADP B-O -human ADJ B-LF -embryonic ADJ I-LF -stem NOUN I-LF -cells NOUN I-LF -( PUNCT B-O -hESCs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -a DET B-O -novel ADJ B-O -in ADP B-O -vitro X B-O -humanized VERB B-O -model NOUN B-O -for ADP B-O -analyzing VERB B-O -the DET B-O -embryotoxicities NOUN B-O -of ADP B-O -chemical ADJ B-O -compounds NOUN B-O -. PUNCT B-O - -The DET B-O -first ADJ B-O -source NOUN B-O -is AUX B-O -the DET B-O -Human PROPN B-LF -Mortality PROPN I-LF -Database PROPN I-LF -( PUNCT B-O -HMD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -consists VERB B-O -of ADP B-O -high ADJ B-O -- PUNCT B-O -quality NOUN B-O -life NOUN B-O -tables NOUN B-O -mostly ADV B-O -from ADP B-O -Western ADJ B-O -countries NOUN B-O -. PUNCT B-O - -CsINV5 PROPN B-AC -expression NOUN B-O -in ADP B-O -cultivar NOUN B-O -SCZ PROPN B-AC -increased VERB B-O -by ADP B-O -three NUM B-O -folds NOUN B-O -at ADP B-O -CA2 NOUN B-O -compared VERB B-O -with ADP B-O -less ADJ B-O -than ADP B-O -one NUM B-O -fold NOUN B-O -in ADP B-O -YH9 PROPN B-AC -( PUNCT B-O -Fig NOUN B-O -6B NUM B-O -) PUNCT B-O -. PUNCT B-O - -Raffinose NOUN B-LF -synthase NOUN I-LF -gene NOUN I-LF -CsRS2 PROPN B-AC -, PUNCT B-O -responsible ADJ B-O -for ADP B-O -synthesizing NOUN B-O -of ADP B-O -raffinose NOUN B-O -, PUNCT B-O -expression NOUN B-O -was AUX B-O -also ADV B-O -increased VERB B-O -during ADP B-O -CA PROPN B-AC -in ADP B-O -variety NOUN B-O -SCZ PROPN B-AC -and CCONJ B-O -then ADV B-O -decreased VERB B-O -following VERB B-O -DA PROPN B-AC -, PUNCT B-O -while SCONJ B-O -it PRON B-O -had VERB B-O -no DET B-O -distinct ADJ B-O -changes NOUN B-O -during ADP B-O -CA PROPN B-AC -in ADP B-O -YH9 PROPN B-AC -( PUNCT B-O -Fig NOUN B-O -6B NUM B-O -) PUNCT B-O -. PUNCT B-O - -This PRON B-O -suggested VERB B-O -that SCONJ B-O -the DET B-O -genes NOUN B-O -responsible ADJ B-O -for ADP B-O -sucrose NOUN B-O -and CCONJ B-O -raffinose NOUN B-O -accumulation NOUN B-O -acted VERB B-O -positively ADV B-O -to PART B-O -regulate VERB B-O -the DET B-O -corresponding VERB B-O -sugar NOUN B-O -accumulation NOUN B-O -in ADP B-O -cold ADJ B-O -treatment NOUN B-O -. PUNCT B-O - -We PRON B-O -did AUX B-O -not PART B-O -observe VERB B-O -any DET B-O -association NOUN B-O -between ADP B-O -the DET B-O -grandmother NOUN B-O -’s PART B-O -smoking NOUN B-O -during ADP B-O -her PRON B-O -pregnancy NOUN B-O -and CCONJ B-O -unilateral ADJ B-O -retinoblastoma NOUN B-O -risk NOUN B-O -in ADP B-O -the DET B-O -grandchild NOUN B-O -( PUNCT B-O -OR PROPN B-AC -, PUNCT B-O -1.1 NUM B-O -; PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -, PUNCT B-O -0.5–2.1 NUM B-O -) PUNCT B-O -with ADP B-O -a DET B-O -slightly ADV B-O -increased VERB B-O -risk NOUN B-O -estimate NOUN B-O -for ADP B-O -bilateral ADJ B-O -retinoblastoma NOUN B-O -development NOUN B-O -, PUNCT B-O -but CCONJ B-O -confidence NOUN B-LF -intervals NOUN I-LF -crossed VERB B-O -the DET B-O -null ADJ B-O -( PUNCT B-O -OR PROPN B-AC -, PUNCT B-O -1.3 NUM B-O -; PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -, PUNCT B-O -0.5–3.1 NUM B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -Poisson PROPN B-LF -generalized ADJ I-LF -likelihood NOUN I-LF -ratio NOUN I-LF -( PUNCT B-O -GLR PROPN B-AC -) PUNCT B-O -was AUX B-O -calculated VERB B-O -for ADP B-O -each DET B-O -window NOUN B-O -of ADP B-O -observed VERB B-O -and CCONJ B-O -expected VERB B-O -number NOUN B-O -of ADP B-O -cases NOUN B-O -in SCONJ B-O -order NOUN B-O -to PART B-O -identify VERB B-O -statistically ADV B-O -significant ADJ B-O -high ADJ B-O -risk NOUN B-O -periods NOUN B-O -. PUNCT B-O - -We PRON B-O -experimentally ADV B-O -addressed VERB B-O -this DET B-O -issue NOUN B-O -by ADP B-O -studying VERB B-O -the DET B-O -maternal ADJ B-O -transmission NOUN B-O -of ADP B-O -random ADJ B-O -mtDNA PROPN B-AC -mutations NOUN B-O -in ADP B-O -mtDNA PROPN B-AC -mutator NOUN B-O -mice NOUN B-O -expressing VERB B-O -a DET B-O -proofreading NOUN B-O -- PUNCT B-O -deficient VERB B-O -mitochondrial ADJ B-LF -DNA NOUN I-LF -polymerase NOUN B-O -. PUNCT B-O - -SE PROPN B-O -: PUNCT B-O -standard ADJ B-O -error NOUN B-O -, PUNCT B-O -CI PROPN B-O -: PUNCT B-O -confidence NOUN B-O -interval NOUN B-O -, PUNCT B-O -ANC PROPN B-AC -: PUNCT B-O -antenatal ADJ B-LF -care NOUN I-LF -, PUNCT B-O -SHP PROPN B-O -: PUNCT B-O -skilled ADJ B-O -health NOUN B-O -professionals NOUN B-O -Dichotomous ADJ B-O -events NOUN B-O -or CCONJ B-O -odds NOUN B-LF -ratios NOUN I-LF -( PUNCT B-O -ORs PROPN B-AC -) PUNCT B-O -of ADP B-O -suicide NOUN B-O -, PUNCT B-O -suicide NOUN B-O -attempt NOUN B-O -, PUNCT B-O -and CCONJ B-O -suicidal ADJ B-O -ideation NOUN B-O -were AUX B-O -analyzed VERB B-O -using VERB B-O -multilevel ADJ B-O -meta NOUN B-O -- NOUN B-O -analyses NOUN B-O -to PART B-O -accommodate VERB B-O -the DET B-O -non NOUN B-O -- NOUN B-O -independence NOUN B-O -of ADP B-O -effect NOUN B-O -sizes NOUN B-O -. PUNCT B-O - -DON PROPN B-AC -, PUNCT B-O -6 NUM B-LF -- PUNCT I-LF -Diazo-5 NOUN I-LF -- PUNCT I-LF -oxo NOUN I-LF -- PUNCT I-LF -L NOUN I-LF -- PUNCT I-LF -norleucine NOUN I-LF -; PUNCT B-O -IHC PROPN B-AC -, PUNCT B-O -immunohistochemistry NOUN B-LF -; PUNCT B-O -MEF PROPN B-AC -, PUNCT B-O -mouse NOUN B-LF -embryonic ADJ I-LF -fibroblast NOUN I-LF -. PUNCT B-O - -We PRON B-O -observed VERB B-O -a DET B-O -significant ADJ B-O -drop NOUN B-O -in ADP B-O -the DET B-O -level NOUN B-O -of ADP B-O -postoperative ADJ B-LF -sVEGFR1 PROPN B-O -than ADP B-O -that PRON B-O -of ADP B-O -the DET B-O -preoperative ADJ B-LF -( PUNCT B-O -median ADJ B-O -sVEGFR1 PROPN B-O -: PUNCT B-O -PREOP PROPN B-AC -, PUNCT B-O -189.6 NUM B-O -pg NOUN B-O -/ SYM B-O -ml NOUN B-O -; PUNCT B-O -POST PROPN B-AC -, PUNCT B-O -124.3 NUM B-O -pg NOUN B-O -/ SYM B-O -ml NOUN B-O -; PUNCT B-O -P NOUN B-O -< SYM B-O -0.0001 NUM B-O -; PUNCT B-O -Fig NUM B-O -5A NUM B-O -) PUNCT B-O -. PUNCT B-O - -Unlike ADP B-O -sVEGFR1 PROPN B-O -, PUNCT B-O -we PRON B-O -did AUX B-O -not PART B-O -observe VERB B-O -significant ADJ B-O -difference NOUN B-O -in ADP B-O -the DET B-O -level NOUN B-O -of ADP B-O -serum NOUN B-O -sVEGFR2 NOUN B-O -between ADP B-O -the DET B-O -two NUM B-O -events NOUN B-O -( PUNCT B-O -median ADJ B-O -sVEGFR2 NOUN B-O -: PUNCT B-O -OPPRE PROPN B-AC -, PUNCT B-O -7773 NUM B-O -pg NOUN B-O -/ SYM B-O -ml NOUN B-O -; PUNCT B-O -OPPOST PROPN B-AC -, PUNCT B-O -8306 NUM B-O -pg NOUN B-O -/ SYM B-O -ml NOUN B-O -; PUNCT B-O -P NOUN B-O -= SYM B-O -0.976 NUM B-O -; PUNCT B-O -Fig NUM B-O -5B NUM B-O -) PUNCT B-O -. PUNCT B-O - -No DET B-O -direct ADJ B-O -association NOUN B-O -between ADP B-O -soluble ADJ B-O -VEGF PROPN B-O -receptors NOUN B-O -and CCONJ B-O -OPIPVEGF-A PROPN B-AC -was AUX B-O -noted VERB B-O -. PUNCT B-O - -For ADP B-O -mortality NOUN B-O -, PUNCT B-O -we PRON B-O -examined VERB B-O -deaths NOUN B-O -from ADP B-O -respiratory ADJ B-LF -and CCONJ I-LF -circulatory ADJ I-LF -( PUNCT B-O -R&C PROPN B-AC -) PUNCT B-O -conditions NOUN B-O -as ADP B-O -a DET B-O -more ADV B-O -specific ADJ B-O -outcome NOUN B-O -for ADP B-O -influenza NOUN B-O -. PUNCT B-O - -Although SCONJ B-O -the DET B-O -Preferred PROPN B-LF -Reporting PROPN I-LF -Items PROPN I-LF -for ADP I-LF -Systematic ADJ I-LF -reviews NOUN I-LF -and CCONJ I-LF -Meta PROPN I-LF -- PUNCT I-LF -Analyses PROPN I-LF -( PUNCT B-O -PRISMA PROPN B-AC -) PUNCT B-O -guidelines NOUN B-O -have AUX B-O -been AUX B-O -critical ADJ B-O -to ADP B-O -the DET B-O -proper ADJ B-O -reporting VERB B-O -of ADP B-O -systematic ADJ B-O -reviews NOUN B-O -[ PUNCT B-O -7,8 NUM B-O -] PUNCT B-O -, PUNCT B-O -they PRON B-O -lack VERB B-O -specificity NOUN B-O -for ADP B-O -reporting VERB B-O -systematic ADJ B-O -reviews NOUN B-O -of ADP B-O -preclinical ADJ B-O -research NOUN B-O -. PUNCT B-O - -Differing VERB B-O -in ADP B-O -allele NOUN B-O -frequency NOUN B-O -across ADP B-O -three NUM B-O -population NOUN B-O -comparisons NOUN B-O -and CCONJ B-O -associated VERB B-O -with ADP B-O -the DET B-O -abundance NOUN B-O -of ADP B-O -Clostridiales NOUN B-O -, NOUN B-O -the DET B-O -genetic ADJ B-O -variant NOUN B-O -rs7587067 NOUN B-O -has VERB B-O -a DET B-O -significantly ADV B-O -higher ADJ B-O -frequency NOUN B-O -in ADP B-O -African ADJ B-O -( PUNCT B-O -minor ADJ B-LF -allele NOUN I-LF -frequency NOUN I-LF -[ X B-O -MAF PROPN B-AC -] X B-O -= PUNCT B-O -0.802 NUM B-O -) PUNCT B-O -versus ADP B-O -East ADJ B-O -Asian ADJ B-O -( PUNCT B-O -MAF PROPN B-AC -= PUNCT B-O -0.190 NUM B-O -, NOUN B-O -FST PROPN B-AC -= PUNCT B-O -0.54 NUM B-O -, NOUN B-O -Chromosome NOUN B-O -= PUNCT B-O -98.7 NUM B-O -% PUNCT B-O -, NOUN B-O -Genome NOUN B-O -- PUNCT B-O -Wide ADJ B-O -= PUNCT B-O -98.9 NUM B-O -% PUNCT B-O -) PUNCT B-O -, NOUN B-O -admixed ADJ B-O -American PROPN B-O -( PUNCT B-O -MAF PROPN B-AC -= PUNCT B-O -0.278 NUM B-O -, NOUN B-O -FST PROPN B-AC -= PUNCT B-O -0.44 NUM B-O -, NOUN B-O -Chromosome NOUN B-O -= PUNCT B-O -99.0 NUM B-O -% PUNCT B-O -, NOUN B-O -Genome NOUN B-O -- PUNCT B-O -Wide ADJ B-O -= PUNCT B-O -99.1 NUM B-O -% PUNCT B-O -) PUNCT B-O -, NOUN B-O -and CCONJ B-O -European ADJ B-O -populations NOUN B-O -( PUNCT B-O -MAF PROPN B-AC -= PUNCT B-O -0.267 NUM B-O -, NOUN B-O -FST PROPN B-AC -= PUNCT B-O -0.45 NUM B-O -, NOUN B-O -Chromosome NOUN B-O -= PUNCT B-O -98.7.3 NUM B-O -% PUNCT B-O -, NOUN B-O -Genome NOUN B-O -- PUNCT B-O -Wide ADJ B-O -= PUNCT B-O -98.7 NUM B-O -% PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -Utilizing VERB B-O -2 NUM B-O -bulk ADJ B-O -RNA-Seq PROPN B-AC -datasets NOUN B-O -( PUNCT B-O -GSE63142 NUM B-O -and CCONJ B-O -GSE130499 PROPN B-O -) PUNCT B-O -of ADP B-O -asthma NOUN B-O -patients NOUN B-O -compared VERB B-O -to ADP B-O -healthy ADJ B-O -controls NOUN B-O -, PUNCT B-O -we PRON B-O -identified VERB B-O -that SCONJ B-O -IRAK3 PROPN B-O -and CCONJ B-O -ADRB2 PROPN B-O -had VERB B-O -significantly ADV B-O -elevated VERB B-O -expression NOUN B-O -( PUNCT B-O -false ADJ B-LF -discovery NOUN I-LF -rate NOUN I-LF -[ X B-O -FDR PROPN B-AC -] X B-O -< ADP B-O -0.05 NUM B-O -) PUNCT B-O -in ADP B-O -asthma NOUN B-O -patients NOUN B-O -. PUNCT B-O - -As ADP B-O -a DET B-O -robust ADJ B-O -fiduciary ADJ B-O -marker NOUN B-O -for ADP B-O -CCPs PROPN B-AC -, PUNCT B-O -clathrin PROPN B-LF -light PROPN I-LF -chain NOUN I-LF -a DET I-LF -( PUNCT B-O -CLCa PROPN B-AC -) PUNCT B-O -carrying VERB B-O -an DET B-O -N NOUN B-O -- PUNCT B-O -terminal ADJ B-O -SNAP PROPN B-O -- PUNCT B-O -fusion NOUN B-O -tag NOUN B-O -was AUX B-O -stably ADV B-O -introduced VERB B-O -in ADP B-O -parallel ADJ B-O -into ADP B-O -both DET B-O -cell NOUN B-O -lines NOUN B-O -via ADP B-O -a DET B-O -lentiviral ADJ B-O -vector NOUN B-O -with ADP B-O -puromycin NOUN B-O -selection NOUN B-O -of ADP B-O -SNAP PROPN B-O -- PUNCT B-O -CLCa PROPN B-AC -expressing VERB B-O -cells NOUN B-O -. PUNCT B-O - -From ADP B-O -S6 PROPN B-O -Fig NOUN B-O -, PUNCT B-O -it PRON B-O -can AUX B-O -also ADV B-O -be AUX B-O -seen VERB B-O -that SCONJ B-O -upon SCONJ B-O -binding VERB B-O -to ADP B-O -dabrafenib NOUN B-O -, PUNCT B-O -radius NOUN B-LF -of ADP I-LF -gyration NOUN I-LF -value NOUN B-O -( PUNCT B-O -Rg PROPN B-AC -) PUNCT B-O -significantly ADV B-O -decreased VERB B-O -. PUNCT B-O - -CHD PROPN B-AC -, PUNCT B-O -coronary ADJ B-LF -heart NOUN I-LF -disease NOUN I-LF -; PUNCT B-O -FMD PROPN B-AC -, PUNCT B-O -flow NOUN B-LF -- PUNCT I-LF -mediated VERB I-LF -dilation NOUN I-LF -; PUNCT B-O -HCAEC PROPN B-AC -, PUNCT B-O -human ADJ B-LF -coronary ADJ I-LF -artery NOUN I-LF -endothelial ADJ I-LF -cell NOUN I-LF -; PUNCT B-O -PCNA PROPN B-O -, PUNCT B-O -proliferating VERB B-O -cell NOUN B-O -nuclear ADJ B-O -antigen NOUN B-O -. PUNCT B-O - -Previous ADJ B-O -connectivity NOUN B-O -studies NOUN B-O -using VERB B-O -EEG PROPN B-AC -have AUX B-O -found VERB B-O -synchronized VERB B-O -beta NOUN B-O -frequency NOUN B-O -oscillations NOUN B-O -in ADP B-O -the DET B-O -basal ADJ B-LF -ganglia NOUN I-LF -( PUNCT B-O -BG PROPN B-AC -) PUNCT B-O -including VERB B-O -cortical ADJ B-O -- PUNCT B-O -thalamic ADJ B-O -, PUNCT B-O -EGP NOUN B-O -/ SYM B-O -IGP NOUN B-O -- PUNCT B-O -thalamic ADJ B-O -, PUNCT B-O -cortical ADJ B-O -- PUNCT B-O -striatal ADJ B-O -, PUNCT B-O -striatal ADJ B-O -- PUNCT B-O -EGP NOUN B-O -/ SYM B-O -IGP NOUN B-O -and CCONJ B-O -cortical ADJ B-O -- PUNCT B-O -SN NOUN B-O -pars NOUN B-O -reticulata NOUN B-O -connections NOUN B-O -[ X B-O -68 NUM B-O -, PUNCT B-O -69 NUM B-O -] PUNCT B-O -indicating VERB B-O -increased VERB B-O -functional ADJ B-O -coupling NOUN B-O -between ADP B-O -these DET B-O -brain NOUN B-O -structures NOUN B-O -in ADP B-O -6-OHDA PROPN B-AC -rats NOUN B-O -. PUNCT B-O - -DIC PROPN B-AC -, PUNCT B-O -differential ADJ B-LF -interference NOUN I-LF -contrast NOUN I-LF -; PUNCT B-O -dsRNA PROPN B-AC -, PUNCT B-O -double ADJ B-LF -- PUNCT I-LF -stranded ADJ I-LF -RNA NOUN I-LF -; PUNCT B-O -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -Oo NOUN B-O -, PUNCT B-O -oocyte NOUN B-O -; PUNCT B-O -Sp NOUN B-O -, PUNCT B-O -sperm NOUN B-O -; PUNCT B-O -RNAi PROPN B-AC -, PUNCT B-O -RNA NOUN B-LF -interference NOUN I-LF -; PUNCT B-O -RT PROPN B-AC -, PUNCT B-O -Reverse ADJ B-LF -transcription NOUN I-LF -polymerase NOUN I-LF -chain NOUN I-LF -reaction NOUN I-LF -. PUNCT B-O - -Population NOUN B-O -density NOUN B-O -is AUX B-O -measured VERB B-O -using VERB B-O -light NOUN B-O -scattering NOUN B-O -( PUNCT B-O -optical ADJ B-LF -density NOUN I-LF -[ PUNCT B-O -OD PROPN B-AC -] PUNCT B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -drug NOUN B-O -concentration NOUN B-O -can AUX B-O -be AUX B-O -adjusted VERB B-O -in ADP B-O -real ADJ B-O -time NOUN B-O -in ADP B-O -response NOUN B-O -to ADP B-O -population NOUN B-O -dynamics NOUN B-O -or CCONJ B-O -predetermined VERB B-O -protocols NOUN B-O -( PUNCT B-O -S1 NUM B-O -Fig NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Esophageal ADJ B-LF -adenocarcinoma NOUN I-LF -( PUNCT B-O -EAC PROPN B-AC -) PUNCT B-O -is AUX B-O -predominantly ADV B-O -a DET B-O -disease NOUN B-O -of ADP B-O -the DET B-O -distal ADJ B-O -esophagus NOUN B-O -and CCONJ B-O -gastroesophageal ADJ B-O -junction NOUN B-O -. PUNCT B-O - -Atherosclerosis NOUN B-O -is AUX B-O -the DET B-O -major ADJ B-O -cause NOUN B-O -for ADP B-O -developing VERB B-O -vascular ADJ B-O -events NOUN B-O -[ PUNCT B-O -2,13–18 NUM B-O -] PUNCT B-O -including VERB B-O -ischemic ADJ B-O -heart NOUN B-O -disease NOUN B-O -, PUNCT B-O -heart NOUN B-O -failure NOUN B-O -, PUNCT B-O -stroke NOUN B-O -, PUNCT B-O -and CCONJ B-O -peripheral ADJ B-LF -arterial ADJ I-LF -occlusive ADJ I-LF -disease NOUN I-LF -( PUNCT B-O -PAOD PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -A DET B-O -genetic ADJ B-O -manipulation NOUN B-O -study NOUN B-O -comparing VERB B-O -double ADJ B-O -( PUNCT B-O -apolipoprotein NOUN B-O -E NOUN B-O -and CCONJ B-O -eNOS PROPN B-AC -) PUNCT B-O -knockout NOUN B-O -with ADP B-O -single ADJ B-O -( PUNCT B-O -apolipoprotein NOUN B-O -E NOUN B-O -) PUNCT B-O -knockout NOUN B-O -model NOUN B-O -demonstrate VERB B-O -that SCONJ B-O -eNOS PROPN B-AC -deficiency NOUN B-O -increases VERB B-O -atherosclerosis NOUN B-O -in ADP B-O -Western ADJ B-O -- PUNCT B-O -type NOUN B-O -diet NOUN B-O -- PUNCT B-O -fed VERB B-O -single ADJ B-O -( PUNCT B-O -apolipoprotein NOUN B-O -E NOUN B-O -) PUNCT B-O -knockout NOUN B-O -mice NOUN B-O -and CCONJ B-O -introduces VERB B-O -an DET B-O -array NOUN B-O -of ADP B-O -cardiovascular ADJ B-O -complications NOUN B-O -, PUNCT B-O -including VERB B-O -myocardial ADJ B-O -infarction NOUN B-O -, PUNCT B-O -heart NOUN B-O -failure NOUN B-O -, PUNCT B-O -and CCONJ B-O -spontaneous ADJ B-O -aortic ADJ B-O -aneurysm NOUN B-O -and CCONJ B-O -dissection NOUN B-O -[ PUNCT B-O -18 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Five NUM B-O -different ADJ B-O -tissues NOUN B-O -and CCONJ B-O -organs NOUN B-O -of ADP B-O -P. NOUN B-O -tepidariorum NOUN B-O -– PUNCT B-O -the DET B-O -midgut NOUN B-LF -glands NOUN I-LF -with ADP I-LF -midgut NOUN I-LF -( PUNCT B-O -MG PROPN B-AC -) PUNCT B-O -, PUNCT B-O -neuroendocrine ADJ B-LF -and CCONJ I-LF -nervous ADJ I-LF -system NOUN I-LF -( PUNCT B-O -NS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -ovaries NOUN B-LF -( PUNCT B-O -OV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -hindgut NOUN B-LF -( PUNCT B-O -HG PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -integument NOUN B-LF -( PUNCT B-O -INT)–were PROPN B-AC -used VERB B-O -for ADP B-O -the DET B-O -analysis NOUN B-O -. PUNCT B-O - -SDMA PROPN B-AC -concentrations NOUN B-O -were AUX B-O -determined VERB B-O -using VERB B-O -liquid NOUN B-LF -chromatography NOUN I-LF -- PUNCT I-LF -mass NOUN I-LF -spectroscopy NOUN I-LF -( PUNCT B-O -LC-MS PROPN B-AC -) PUNCT B-O -as SCONJ B-O -previously ADV B-O -described VERB B-O -[ PUNCT B-O -6 NUM B-O -] PUNCT B-O -. PUNCT B-O - -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -HR PROPN B-AC -, PUNCT B-O -hazard NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -SD PROPN B-AC -, PUNCT B-O -standard ADJ B-LF -deviation NOUN I-LF -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -RE PROPN B-AC --ZINB PROPN B-AC -, PUNCT B-O -random ADJ B-LF -- PUNCT I-LF -effects NOUN I-LF -zero NUM B-LF -- PUNCT I-LF -inflated VERB I-LF -negative ADJ I-LF -binomial NOUN I-LF -; PUNCT B-O -IRR PROPN B-AC -, PUNCT B-O -incidence NOUN B-LF -rate NOUN I-LF -ratio NOUN I-LF -; PUNCT B-O -CI NOUN B-O -, PUNCT B-O -confidence NOUN B-O -interval NOUN B-O -; PUNCT B-O -OR PROPN B-AC -, PUNCT B-O -odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -LLIN PROPN B-AC -, PUNCT B-O -long ADV B-LF -- PUNCT I-LF -lasting VERB I-LF -insecticidal ADJ I-LF -bed NOUN I-LF -net NOUN I-LF -; PUNCT B-O -IRS PROPN B-AC -, PUNCT B-O -indoor ADJ B-LF -residual ADJ I-LF -spraying NOUN I-LF -. PUNCT B-O - -Trajectories NOUN B-O -of ADP B-O -HAQ PROPN B-AC -scores NOUN B-O -over ADP B-O -follow NOUN B-O -- PUNCT B-O -up NOUN B-O -were AUX B-O -assessed VERB B-O -using VERB B-O -latent ADJ B-LF -class NOUN I-LF -growth NOUN I-LF -models NOUN I-LF -( PUNCT B-O -LCGMs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -multivariate ADJ B-O -logistic ADJ B-O -regression NOUN B-O -model NOUN B-O -was AUX B-O -fit ADJ B-O -to PART B-O -determine VERB B-O -the DET B-O -association NOUN B-O -between ADP B-O -the DET B-O -patient NOUN B-O -specific ADJ B-O -factors NOUN B-O -and CCONJ B-O -the DET B-O -occurrence NOUN B-O -of ADP B-O -the DET B-O -different ADJ B-O -types NOUN B-O -of ADP B-O -DTPs PROPN B-AC -. PUNCT B-O - -Comparison NOUN B-O -of ADP B-O -factors NOUN B-O -contributing VERB B-O -for ADP B-O -drug NOUN B-LF -therapy NOUN I-LF -problems NOUN I-LF -were AUX B-O -shown VERB B-O -using VERB B-O -odd ADJ B-O -ratios NOUN B-O -. PUNCT B-O - -Because SCONJ B-O -loss NOUN B-O -of ADP B-O -CG6866 NOUN B-O -function NOUN B-O -de VERB B-O -- PUNCT B-O -silences VERB B-O -both CCONJ B-O -endogenous ADJ B-O -silencing NOUN B-O -and CCONJ B-O -reporter NOUN B-O -expression NOUN B-O -in ADP B-O -vivo ADV B-O -( PUNCT B-O -below ADV B-O -) PUNCT B-O -, PUNCT B-O -we PRON B-O -named VERB B-O -the DET B-O -gene NOUN B-O -loquacious ADJ B-O -( PUNCT B-O -loqs PROPN B-O -) PUNCT B-O -. PUNCT B-O - -loqs PROPN B-O -is AUX B-O -located VERB B-O -on ADP B-O -the DET B-O -left ADJ B-O -arm NOUN B-O -of ADP B-O -Chromosome NOUN B-O -2 NUM B-O -at ADP B-O -polytene NOUN B-O -band NOUN B-O -34B9 NUM B-O -. PUNCT B-O - -loqs PROPN B-O -produces VERB B-O -at ADP B-O -least ADV B-O -three NUM B-O -different ADJ B-O -mRNA NOUN B-O -isoforms NOUN B-O -through ADP B-O -alternative ADJ B-O -splicing NOUN B-O -( PUNCT B-O -Figure PROPN B-O -1B NUM B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -shortest ADJ B-O -transcript NOUN B-O -, PUNCT B-O -loqs PROPN B-O -RNA NOUN B-LF -splice NOUN I-LF -variant NOUN I-LF -A PROPN I-LF -( PUNCT B-O -RA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -encodes VERB B-O -a DET B-O -419 NUM B-O -- PUNCT B-O -amino NOUN B-O -- PUNCT B-O -acid NOUN B-O -protein NOUN B-O -, PUNCT B-O -Loqs PROPN B-O -protein NOUN B-LF -isoform NOUN I-LF -A PROPN I-LF -( PUNCT B-O -PA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -with ADP B-O -a DET B-O -predicted VERB B-O -molecular ADJ B-O -mass NOUN B-O -of ADP B-O -45 NUM B-O -kDa NOUN B-O -. PUNCT B-O - -The DET B-O -transcript NOUN B-O -loqs PROPN B-O -RNA NOUN B-LF -splice NOUN I-LF -variant NOUN I-LF -B PROPN I-LF -( PUNCT B-O -RB PROPN B-AC -) PUNCT B-O -contains VERB B-O -one NUM B-O -additional ADJ B-O -exon NOUN B-O -and CCONJ B-O -encodes VERB B-O -a DET B-O -protein NOUN B-O -of ADP B-O -465 NUM B-O -amino NOUN B-O -acids NOUN B-O -, PUNCT B-O -Loqs PROPN B-O -protein NOUN B-LF -isoform NOUN I-LF -B PROPN I-LF -( PUNCT B-O -PB PROPN B-AC -) PUNCT B-O -, PUNCT B-O -with ADP B-O -a DET B-O -predicted VERB B-O -molecular ADJ B-O -mass NOUN B-O -of ADP B-O -50 NUM B-O -kDa NOUN B-O -. PUNCT B-O - -These DET B-O -two NUM B-O -mRNA NOUN B-O -species NOUN B-O -were AUX B-O -identified VERB B-O -as ADP B-O -cDNAs NOUN B-O -in ADP B-O -the DET B-O -Drosophila PROPN B-O -genome NOUN B-O -sequencing NOUN B-O -project NOUN B-O -and CCONJ B-O -annotated VERB B-O -in ADP B-O -FlyBase PROPN B-O -[ X B-O -38 NUM B-O -] X B-O -among ADP B-O -the DET B-O -Drosophila PROPN B-O -proteins NOUN B-O -that PRON B-O -contain VERB B-O -dsRBDs PROPN B-AC -. PUNCT B-O - -Using VERB B-O -non ADJ B-O -- PUNCT B-O -quantitative ADJ B-O -RT NOUN B-O -- PUNCT B-O -PCR NOUN B-O -, PUNCT B-O -we PRON B-O -detected VERB B-O -a DET B-O -third ADJ B-O -splice NOUN B-O -variant NOUN B-O -, PUNCT B-O -loqs PROPN B-O -RNA NOUN B-LF -splice NOUN I-LF -variant NOUN I-LF -C PROPN I-LF -( PUNCT B-O -RC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -in ADP B-O -which PRON B-O -an DET B-O -alternative ADJ B-O -splice NOUN B-O -acceptor NOUN B-O -site NOUN B-O -for ADP B-O -exon NOUN B-O -4 NUM B-O -is AUX B-O -used VERB B-O -( PUNCT B-O -Figure PROPN B-O -1B NUM B-O -, PUNCT B-O -C PROPN B-O -, PUNCT B-O -and CCONJ B-O -D NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Use NOUN B-O -of ADP B-O -the DET B-O -alternative ADJ B-O -splice NOUN B-O -site NOUN B-O -creates VERB B-O -a DET B-O -5′-extended ADJ B-O -fourth ADJ B-O -exon NOUN B-O -and CCONJ B-O -changes VERB B-O -the DET B-O -reading NOUN B-O -frame NOUN B-O -, PUNCT B-O -resulting VERB B-O -in ADP B-O -a DET B-O -truncated VERB B-O -protein NOUN B-O -, PUNCT B-O -Loqs PROPN B-O -protein NOUN B-LF -isoform NOUN I-LF -C PROPN I-LF -( PUNCT B-O -PC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -383 NUM B-O -amino NOUN B-O -acids NOUN B-O -long ADJ B-O -( PUNCT B-O -Figure PROPN B-O -1C NUM B-O -) PUNCT B-O -. PUNCT B-O - -Loqs PROPN B-O -PC PROPN B-AC -has VERB B-O -a DET B-O -predicted VERB B-O -molecular ADJ B-O -mass NOUN B-O -of ADP B-O -41 NUM B-O -kDa NOUN B-O -and CCONJ B-O -lacks VERB B-O -the DET B-O -entire ADJ B-O -third ADJ B-O -dsRBD PROPN B-AC -of ADP B-O -Loqs PROPN B-O -PA PROPN B-AC -and CCONJ B-O -PB PROPN B-AC -( PUNCT B-O -Figure PROPN B-O -1B NUM B-O -) PUNCT B-O -. PUNCT B-O - -loqs PROPN B-O -RA PROPN B-AC -is AUX B-O -the DET B-O -predominant ADJ B-O -mRNA NOUN B-O -species NOUN B-O -in ADP B-O -dissected ADJ B-O -testes NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -loqs PROPN B-O -RB PROPN B-AC -is AUX B-O -the DET B-O -most ADV B-O -abundant ADJ B-O -species NOUN B-O -in ADP B-O -ovaries NOUN B-O -. PUNCT B-O - -Autotaxin PROPN B-LF -( PUNCT B-O -ATX PROPN B-AC -) PUNCT B-O -has VERB B-O -a DET B-O -profibrotic ADJ B-O -effect NOUN B-O -resulting VERB B-O -from ADP B-O -lysophosphatidic ADJ B-O -acid NOUN B-O -activity NOUN B-O -. PUNCT B-O - -Only ADV B-O -markers NOUN B-O -with ADP B-O -known VERB B-O -map NOUN B-O -positions NOUN B-O -were AUX B-O -used VERB B-O -to PART B-O -perform VERB B-O -linkage NOUN B-LF -disequilibrium NOUN I-LF -( PUNCT B-O -LD PROPN B-AC -) PUNCT B-O -analysis NOUN B-O -with ADP B-O -TASSEL PROPN B-O -3.0 NUM B-O -[ PUNCT B-O -37 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Response NOUN B-O -: PUNCT B-O -Sucrose NOUN B-O -in ADP B-O -full ADJ B-O -form NOUN B-O -in ADP B-O -heading NOUN B-O -or CCONJ B-O -subheadings NOUN B-O -has AUX B-O -been AUX B-O -mentioned VERB B-O -, PUNCT B-O -and CCONJ B-O -“ PUNCT B-O -Determination PROPN B-O -of ADP B-O -Chl PROPN B-AC -Precursors NOUN B-O -” PUNCT B-O -has AUX B-O -been AUX B-O -replaced VERB B-O -by ADP B-O -“ PUNCT B-O -Determination PROPN B-O -of ADP B-O -Chlorophyll PROPN B-LF -Precursors NOUN B-O -” PUNCT B-O -. PUNCT B-O - -This DET B-O -study NOUN B-O -was AUX B-O -approved VERB B-O -by ADP B-O -the DET B-O -institutional ADJ B-O -review NOUN B-O -boards NOUN B-O -of ADP B-O -Kyoto PROPN B-LF -Prefectural PROPN I-LF -University PROPN I-LF -of ADP I-LF -Medicine PROPN I-LF -( PUNCT B-O -KPUM PROPN B-AC -) PUNCT B-O -and CCONJ B-O -the DET B-O -National PROPN B-O -Institute PROPN B-O -of ADP B-O -Health PROPN B-O -Sciences PROPN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -ITH PROPN B-AC -( PUNCT B-O -intra ADJ B-LF -- PUNCT I-LF -tumour ADJ I-LF -heterogeneity NOUN I-LF -) PUNCT B-O -, PUNCT B-O -OC PROPN B-AC -( PUNCT B-O -ovarian ADJ B-O -carcinoma NOUN B-O -) PUNCT B-O -, PUNCT B-O -BRCA PROPN B-AC -( PUNCT B-O -breast ADJ B-LF -cancer NOUN I-LF -invasive ADJ I-LF -carcinoma NOUN I-LF -) PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -are AUX B-O -available ADJ B-O -from ADP B-O -the DET B-O -Ethical PROPN B-O -Review PROPN B-O -Committee PROPN B-O -and/or CCONJ B-O -Research PROPN B-O -Administration PROPN B-O -of ADP B-O -International PROPN B-LF -Centre PROPN I-LF -for ADP I-LF -Diarrhoeal PROPN I-LF -Disease PROPN I-LF -Research PROPN I-LF -, X I-LF -Bangladesh PROPN I-LF -( PUNCT B-O -icddr,b PROPN B-AC -) PUNCT B-O -for ADP B-O -researchers NOUN B-O -who PRON B-O -meet VERB B-O -the DET B-O -criteria NOUN B-O -for ADP B-O -access NOUN B-O -to ADP B-O -confidential ADJ B-O -data NOUN B-O -. PUNCT B-O - -Results NOUN B-O -are AUX B-O -presented VERB B-O -as ADP B-O -adjusted VERB B-LF -odds NOUN I-LF -ratios NOUN I-LF -( PUNCT B-O -aOR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -intervals NOUN I-LF -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -) PUNCT B-O -and CCONJ B-O -their PRON B-O -p NOUN B-O -- PUNCT B-O -values NOUN B-O -. PUNCT B-O - -( PUNCT B-O -A X B-O -) PUNCT B-O -Gene NOUN B-O -induction NOUN B-O -determined VERB B-O -by ADP B-O -qRT-PCR PROPN B-AC -with ADP B-O -parental ADJ B-O -( PUNCT B-O -S2-/- PROPN B-O -) PUNCT B-O -and CCONJ B-O -stably ADV B-O -STAT2 PROPN B-O -- PUNCT B-O -reconstituted VERB B-O -( PUNCT B-O -S2 PROPN B-O -WT PROPN B-AC -or CCONJ B-O -S2 PROPN B-O -L82A NOUN B-O -) PUNCT B-O -human ADJ B-O -U6A PROPN B-O -cells NOUN B-O -after ADP B-O -treatment NOUN B-O -with ADP B-O -IFN PROPN B-AC -- PUNCT B-O -β PUNCT B-O -( PUNCT B-O -500 NUM B-O -U NOUN B-O -/ NOUN B-O -ml NOUN B-O -) PUNCT B-O -for ADP B-O -4 NUM B-O -h. NOUN B-O -( PUNCT B-O -B X B-O -) PUNCT B-O -STAT1 PROPN B-O -- PUNCT B-O -CFP PROPN B-AC -and CCONJ B-O -YFP PROPN B-AC -- PUNCT B-O -tagged VERB B-O -wild ADJ B-LF -type NOUN I-LF -( PUNCT B-O -top ADJ B-O -panels NOUN B-O -) PUNCT B-O -or CCONJ B-O -L82A NOUN B-O -mutated VERB B-O -STAT2 PROPN B-O -( PUNCT B-O -bottom ADJ B-O -panels NOUN B-O -) PUNCT B-O -were AUX B-O -co VERB B-O -- PUNCT B-O -expressed VERB B-O -in ADP B-O -HeLa PROPN B-O -cells NOUN B-O -and CCONJ B-O -their PRON B-O -subcellular ADJ B-O -localization NOUN B-O -was AUX B-O -observed VERB B-O -by ADP B-O -deconvolution NOUN B-O -microscopy NOUN B-O -after ADP B-O -1 NUM B-O -h NOUN B-O -in ADP B-O -the DET B-O -presence NOUN B-O -of ADP B-O -IFN PROPN B-AC -- PUNCT B-O -β PUNCT B-O -. PUNCT B-O - -1Treatments NOUN B-O -: PUNCT B-O -CON PROPN B-AC -= PUNCT B-O -Piglets NOUN B-O -drenched VERB B-O -with ADP B-O -2 NUM B-O -mL NOUN B-O -tap NOUN B-O -water NOUN B-O -until ADP B-O -d NOUN B-O -7 NUM B-O -; PUNCT B-O -T1 NOUN B-O -= PUNCT B-O -Piglets NOUN B-O -drenched VERB B-O -with ADP B-O -1 NUM B-O -g NOUN B-O -short ADJ B-LF -- PUNCT I-LF -chain NOUN I-LF -fructo NOUN I-LF -- PUNCT I-LF -oligosaccharides NOUN I-LF -( PUNCT B-O -scFOS PROPN B-AC -, PUNCT B-O -Profeed PROPN B-O -P95 PROPN B-O -, PUNCT B-O -Beghin PROPN B-O -- PUNCT B-O -Meiji PROPN B-O -) PUNCT B-O -dissolved VERB B-O -in ADP B-O -2 NUM B-O -mL NOUN B-O -tap NOUN B-O -water NOUN B-O -until ADP B-O -d NOUN B-O -7 NUM B-O -; PUNCT B-O -T2 NOUN B-O -= PUNCT B-O -Piglets NOUN B-O -drenched VERB B-O -with ADP B-O -1 NUM B-O -g NOUN B-O -scFOS PROPN B-AC -dissolved VERB B-O -in ADP B-O -2 NUM B-O -mL NOUN B-O -tap NOUN B-O -water NOUN B-O -until ADP B-O -d NOUN B-O -21.5 NUM B-O -( PUNCT B-O -weaning NOUN B-O -age NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Safety NOUN B-O -assessments NOUN B-O -were AUX B-O -performed VERB B-O -in ADP B-O -a DET B-O -standardized ADJ B-O -method NOUN B-O -at ADP B-O -each DET B-O -study NOUN B-O -visit NOUN B-O -and CCONJ B-O -included VERB B-O -the DET B-O -evaluation NOUN B-O -of ADP B-O -adverse ADJ B-LF -events NOUN I-LF -( PUNCT B-O -AEs PROPN B-AC -): PUNCT B-O -serious ADJ B-O -AEs PROPN B-AC -( PUNCT B-O -SAEs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -severe ADJ B-O -AEs PROPN B-AC -, PUNCT B-O -treatment NOUN B-O -- PUNCT B-O -related VERB B-O -AEs PROPN B-AC -, PUNCT B-O -procedure NOUN B-O -- PUNCT B-O -related VERB B-O -AEs PROPN B-AC -( PUNCT B-O -i.e. X B-O -The DET B-O -second ADJ B-O -objective NOUN B-O -was AUX B-O -to PART B-O -evaluate VERB B-O -the DET B-O -utility NOUN B-O -of ADP B-O -‘ PUNCT B-O -TB PROPN B-AC -Transport NOUN B-O -’ PUNCT B-O -( PUNCT B-O -containing VERB B-O -Trans-Filter PROPN B-AC -) PUNCT B-O -and CCONJ B-O -‘ PUNCT B-O -TB PROPN B-AC -DNA NOUN B-O -Extraction NOUN B-O -’ PUNCT B-O -kits NOUN B-O -for ADP B-O -sputum NOUN B-O -transport NOUN B-O -, PUNCT B-O -tuberculosis NOUN B-LF -M.tuberculosis PROPN B-AC -DNA NOUN B-O -isolation NOUN B-O -and CCONJ B-O -Mol-DST PROPN B-AC -assay NOUN B-O -, PUNCT B-O -taking VERB B-O -phenotypic ADJ B-O -DST NOUN B-O -as ADP B-O -the DET B-O -reference NOUN B-O -standard NOUN B-O -. PUNCT B-O - -We PRON B-O -here ADV B-O -show VERB B-O -that SCONJ B-O -cell NOUN B-O -- PUNCT B-O -type NOUN B-O -– AUX B-O -specific ADJ B-O -reduction NOUN B-O -of ADP B-O -cyclin NOUN B-LF -- PUNCT I-LF -dependent ADJ I-LF -kinase NOUN I-LF -5 NUM I-LF -( PUNCT B-O -cdk5 PROPN B-AC -) PUNCT B-O -activity NOUN B-O -in ADP B-O -newborn ADJ B-O -neurons NOUN B-O -results VERB B-O -in ADP B-O -impaired VERB B-O -neuronal ADJ B-O -migration NOUN B-O -and CCONJ B-O -leads VERB B-O -to ADP B-O -the DET B-O -extension NOUN B-O -of ADP B-O -incorrectly ADV B-O -targeted VERB B-O -neuronal ADJ B-O -processes NOUN B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -we PRON B-O -performed VERB B-O -disuccinimidyl NOUN B-LF -sulfoxide NOUN I-LF -( PUNCT B-O -DSSO PROPN B-AC -: PUNCT B-O -a DET B-O -mass NOUN B-LF -spectrometry NOUN I-LF -- PUNCT B-O -cleavable ADJ B-O -crosslinker NOUN B-O -) PUNCT B-O -crosslinking NOUN B-O -of ADP B-O -kindlin-3 NOUN B-O -monomer NOUN B-O -and CCONJ B-O -trimer NOUN B-O -followed VERB B-O -by ADP B-O -analytical ADJ B-O -gel NOUN B-O -filtration NOUN B-O -and CCONJ B-O -mass NOUN B-LF -spectrometry NOUN I-LF -( PUNCT B-O -MS PROPN B-AC -) PUNCT B-O -analysis NOUN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -ART PROPN B-AC -, PUNCT B-O -antiretroviral ADJ B-LF -therapy NOUN I-LF -; PUNCT B-O -CI PROPN B-AC -, PUNCT B-O -confidence NOUN B-LF -interval NOUN I-LF -; PUNCT B-O -HAZ PROPN B-AC -, PUNCT B-O -WHO PROPN B-AC -height NOUN B-O -- PUNCT B-O -for ADP B-O -- PUNCT B-O -age NOUN B-O -Z NOUN B-O -- PUNCT B-O -score NOUN B-O -; PUNCT B-O -IQR PROPN B-AC -, PUNCT B-O -interquartile ADJ B-LF -range NOUN I-LF -; PUNCT B-O -LTFU PROPN B-AC -, PUNCT B-O -loss NOUN B-O -to PART B-O -follow VERB B-O -- PUNCT B-O -up ADP B-O -. PUNCT B-O - -Since SCONJ B-O -fructose NOUN B-O -metabolism NOUN B-O -is VERB B-O -insulin NOUN B-O -- PUNCT B-O -independent ADJ B-O -[ PUNCT B-O -2 X B-O -] PUNCT B-O -, PUNCT B-O -there PRON B-O -is VERB B-O -less ADJ B-O -uptake NOUN B-O -and CCONJ B-O -catabolism NOUN B-O -of ADP B-O -triglyceride NOUN B-LF -( PUNCT B-O -TG)-rich PROPN B-AC -lipoproteins NOUN B-O -by ADP B-O -tissues NOUN B-O -, PUNCT B-O -ultimately ADV B-O -resulting VERB B-O -in ADP B-O -increased VERB B-O -postprandial ADJ B-O -plasma NOUN B-O -TG PROPN B-AC -levels NOUN B-O -[ PUNCT B-O -8 NUM B-O -] PUNCT B-O -. PUNCT B-O - -CONSORT PROPN B-AC -has AUX B-O -been AUX B-O -endorsed VERB B-O -by ADP B-O -the DET B-O -World PROPN B-LF -Association PROPN I-LF -of ADP I-LF -Medical PROPN I-LF -Editors PROPN I-LF -( PUNCT B-O -WAME PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -International PROPN B-LF -Committee PROPN I-LF -of ADP I-LF -Medical PROPN I-LF -Journal PROPN I-LF -Editors PROPN I-LF -( PUNCT B-O -ICMJE PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -Council PROPN B-LF -of ADP I-LF -Science PROPN I-LF -Editors PROPN I-LF -( PUNCT B-O -CSE PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Currently ADV B-O -, PUNCT B-O -however ADV B-O -, PUNCT B-O -the DET B-O -CONSORT PROPN B-AC -Statement PROPN B-O -provides VERB B-O -limited ADJ B-O -guidance NOUN B-O -about ADP B-O -preparing VERB B-O -abstracts NOUN B-O -and CCONJ B-O -, PUNCT B-O -while SCONJ B-O -it PRON B-O -encourages VERB B-O -the DET B-O -use NOUN B-O -of ADP B-O -a DET B-O -structured ADJ B-O -format NOUN B-O -, PUNCT B-O -this PRON B-O -is AUX B-O -not PART B-O -a DET B-O -formal ADJ B-O -requirement NOUN B-O -. PUNCT B-O - -To PART B-O -correlate VERB B-O -responsiveness NOUN B-O -of ADP B-O -ccRCC PROPN B-AC -cell NOUN B-O -lines NOUN B-O -to ADP B-O -established VERB B-O -forms NOUN B-O -of ADP B-O -treatments NOUN B-O -with ADP B-O -extent NOUN B-O -of ADP B-O -genomic ADJ B-O -aberrations NOUN B-O -, PUNCT B-O -we PRON B-O -analyzed VERB B-O -a DET B-O -subset NOUN B-O -of ADP B-O -malignant ADJ B-O -clear ADJ B-O -cell NOUN B-O -renal ADJ B-O -cell NOUN B-O -lines NOUN B-O -, PUNCT B-O -via ADP B-O -The DET B-LF -Cancer PROPN I-LF -Genome PROPN I-LF -Atlas PROPN I-LF -( PUNCT B-O -TCGA PROPN B-AC -: PUNCT B-O -[ X B-O -28 NUM B-O -, PUNCT B-O -29 NUM B-O -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -are AUX B-O -means NOUN B-O -± SYM B-O -s.d NOUN B-O -. PUNCT B-O - -( PUNCT B-O -* PUNCT B-O -p NOUN B-O -= X B-O -0.06 NUM B-O -, PUNCT B-O -* PUNCT B-O -* PUNCT B-O -p NOUN B-O -= X B-O -0.0012 NUM B-O -, PUNCT B-O -* PUNCT B-O -* PUNCT B-O -* PUNCT B-O -p NOUN B-O -= X B-O -0.0005 NUM B-O -) PUNCT B-O -. PUNCT B-O - -β PUNCT B-O -- PUNCT B-O -Galactosidase NOUN B-O -( PUNCT B-O -puc-lacZ PROPN B-AC -) PUNCT B-O -, PUNCT B-O -purple ADJ B-O -; PUNCT B-O -Ptc PROPN B-AC -, PUNCT B-O -green NOUN B-O -; PUNCT B-O -DAPI NOUN B-O -, PUNCT B-O -turquoise NOUN B-O -; PUNCT B-O -En PROPN B-AC -, PUNCT B-O -red NOUN B-O -. PUNCT B-O - -( PUNCT B-O -A NOUN B-O -– PUNCT B-O -C PROPN B-O -) PUNCT B-O -( PUNCT B-O -right ADJ B-O -panels NOUN B-O -) PUNCT B-O -Scheme NOUN B-O -of ADP B-O -the DET B-O -phenotype NOUN B-O -and CCONJ B-O -expression NOUN B-O -patterns NOUN B-O -of ADP B-O -Wg PROPN B-AC -and CCONJ B-O -En PROPN B-AC -; PUNCT B-O -PS PROPN B-AC -is AUX B-O -for ADP B-O -parasegment NOUN B-LF -boundary NOUN B-O -and CCONJ B-O -S PROPN B-O -for ADP B-O -segment NOUN B-O -boundary NOUN B-O -. PUNCT B-O - -( PUNCT B-O -D X B-O -) PUNCT B-O -Model NOUN B-O -of ADP B-O -JNK PROPN B-O -induced VERB B-O -reprogramming NOUN B-O -at ADP B-O -the DET B-O -segment NOUN B-O -boundary NOUN B-O -and CCONJ B-O -Wg PROPN B-AC -inhibition NOUN B-O -at ADP B-O -the DET B-O -parasegment NOUN B-LF -boundary NOUN B-O -. PUNCT B-O - -More ADV B-O -recently ADV B-O -, PUNCT B-O -several ADJ B-O -PCP PROPN B-AC -pathway NOUN B-O -components NOUN B-O -, PUNCT B-O -like ADP B-O -the DET B-O -Wnt NOUN B-O -receptor NOUN B-O -Frizzled PROPN B-LF -( PUNCT B-O -Fz PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Flamingo PROPN B-LF -( PUNCT B-O -Fmi PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Strabismus PROPN B-O -( PUNCT B-O -Stbm PROPN B-O -or CCONJ B-O -Vang PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -Dsh PROPN B-AC -, PUNCT B-O -have AUX B-O -been AUX B-O -shown VERB B-O -to PART B-O -play VERB B-O -a DET B-O -role NOUN B-O -in ADP B-O -the DET B-O -correct ADJ B-O -targeting NOUN B-O -and CCONJ B-O -bifurcation NOUN B-O -of ADP B-O -MB PROPN B-AC -axons NOUN B-O -[ PUNCT B-O -4],[30],[31 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Error NOUN B-O -bars NOUN B-O -denote VERB B-O -standard ADJ B-LF -errors NOUN I-LF -of ADP I-LF -means NOUN I-LF -( PUNCT B-O -SEM PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Underlying VERB B-O -data NOUN B-O -can AUX B-O -be AUX B-O -found VERB B-O -in ADP B-O -S1 PROPN B-O -Data PROPN B-O -. PUNCT B-O - -Thus ADV B-O -, PUNCT B-O -we PRON B-O -here ADV B-O -decided VERB B-O -to PART B-O -perform VERB B-O -all DET B-O -reactions NOUN B-O -in ADP B-O -DMSO NOUN B-O -- PUNCT B-O -free ADJ B-O -aqueous ADJ B-O -buffers NOUN B-O -using VERB B-O -N NOUN B-LF -, PUNCT I-LF -N NOUN I-LF -, PUNCT I-LF -N’,N’,N”-pentamethyldiethylenetriamine NOUN I-LF -( PUNCT B-O -PMDETA PROPN B-AC -) PUNCT B-O -as ADP B-O -a DET B-O -Cu NOUN B-O -( PUNCT B-O -I NOUN B-O -) PUNCT B-O -stabilizing VERB B-O -agent NOUN B-O -for ADP B-O -the DET B-O -conjugation NOUN B-O -of ADP B-O -the DET B-O -RNA NOUN B-O -aptamer NOUN B-O -Gint4.T PROPN B-O -to PART B-O -MP PROPN B-AC -. PUNCT B-O - -The DET B-O -advantage NOUN B-O -of ADP B-O -PMDETA PROPN B-AC -is AUX B-O -its PRON B-O -water NOUN B-O -solubility NOUN B-O -and CCONJ B-O -ease NOUN B-O -to PART B-O -separate VERB B-O -from ADP B-O -the DET B-O -reaction NOUN B-O -mixture NOUN B-O -upon SCONJ B-O -purification NOUN B-O -of ADP B-O -the DET B-O -conjugate NOUN B-O -[ PUNCT B-O -27 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Human ADJ B-LF -papillomavirus NOUN I-LF -( PUNCT B-O -HPV PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -name NOUN B-O -of ADP B-O -a DET B-O -group NOUN B-O -of ADP B-O -viruses NOUN B-O -that PRON B-O -includes VERB B-O -more ADJ B-O -than ADP B-O -100 NUM B-O -different ADJ B-O -strains NOUN B-O -or CCONJ B-O -types NOUN B-O -; PUNCT B-O -more ADJ B-O -than ADP B-O -30 NUM B-O -of ADP B-O -these DET B-O -viruses NOUN B-O -are AUX B-O -sexually ADV B-O -transmitted VERB B-O -. PUNCT B-O - -From ADP B-O -those DET B-O -predictive ADJ B-O -models NOUN B-O -the DET B-O -performance NOUN B-O -( PUNCT B-O -i.e. X B-O -, PUNCT B-O -ROCAUC PROPN B-AC -; PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval NOUN I-LF -, PUNCT B-O -CI PROPN B-AC -) PUNCT B-O -for ADP B-O -classifying VERB B-O -the DET B-O -input NOUN B-O -phenotypic ADJ B-O -groups NOUN B-O -( PUNCT B-O -e.g. X B-O -, PUNCT B-O -cases NOUN B-O -versus ADP B-O -controls NOUN B-O -) PUNCT B-O -are AUX B-O -provided VERB B-O -. PUNCT B-O - -Flow NOUN B-O -cytometry NOUN B-O -analysis NOUN B-O -of ADP B-O -uterine ADJ B-O -implantation NOUN B-O -sites NOUN B-O -following VERB B-O -removal NOUN B-O -of ADP B-O -the DET B-O -placenta NOUN B-O -/ SYM B-O -embryo NOUN B-O -demonstrated VERB B-O -that SCONJ B-O -the DET B-O -percentage NOUN B-O -of ADP B-O -BM PROPN B-AC -- NOUN B-O -derived VERB B-O -GFP+ PROPN B-AC -cells NOUN B-O -in ADP B-O -the DET B-O -implantation NOUN B-O -site NOUN B-O -increased VERB B-O -as SCONJ B-O -pregnancy NOUN B-O -progressed VERB B-O -to ADP B-O -mid NOUN B-O -- NOUN B-O -gestation NOUN B-O -; PUNCT B-O -it PRON B-O -increased VERB B-O -significantly ADV B-O -on ADP B-O -the DET B-O -day NOUN B-O -of ADP B-O -implantation NOUN B-O -( PUNCT B-O -E5.5 NUM B-O -) PUNCT B-O -( PUNCT B-O -15.8 NUM B-O -% NOUN B-O -) PUNCT B-O -as SCONJ B-O -compared VERB B-O -with ADP B-O -the DET B-O -nonpregnant ADJ B-O -state NOUN B-O -( PUNCT B-O -9.2 NUM B-O -% NOUN B-O -) PUNCT B-O -, PUNCT B-O -peaking VERB B-O -on ADP B-O -E9.5 NUM B-O -( PUNCT B-O -24.1 NUM B-O -% NOUN B-O -) PUNCT B-O -, PUNCT B-O -followed VERB B-O -by ADP B-O -a DET B-O -gradual ADJ B-O -decrease NOUN B-O -on ADP B-O -E13.5 NUM B-O -( PUNCT B-O -16.7 NUM B-O -% NOUN B-O -) PUNCT B-O -and CCONJ B-O -peripartum NOUN B-O -( PUNCT B-O -E17.5 NUM B-O -) PUNCT B-O -( PUNCT B-O -13.1 NUM B-O -% NOUN B-O -) PUNCT B-O -( PUNCT B-O -Fig NOUN B-O -1D NUM B-O -and CCONJ B-O -1F NUM B-O -) PUNCT B-O -. PUNCT B-O - -As SCONJ B-O -the DET B-O -observed VERB B-O -increase NOUN B-O -in ADP B-O -GFP+ PROPN B-AC -cells NOUN B-O -in ADP B-O -the DET B-O -decidua NOUN B-O -during ADP B-O -pregnancy NOUN B-O -could AUX B-O -be AUX B-O -due ADJ B-O -to ADP B-O -local ADJ B-O -proliferation NOUN B-O -of ADP B-O -BMDCs PROPN B-AC -and CCONJ B-O -not PART B-O -only ADV B-O -to ADP B-O -increased VERB B-O -recruitment NOUN B-O -, PUNCT B-O -we PRON B-O -assessed VERB B-O -cell NOUN B-O -proliferation NOUN B-O -using VERB B-O -proliferating VERB B-LF -cell NOUN I-LF -nuclear ADJ I-LF -antigen NOUN I-LF -( PUNCT B-O -PCNA PROPN B-AC -) PUNCT B-O -staining NOUN B-O -. PUNCT B-O - -To PART B-O -characterize VERB B-O -its PRON B-O -carbohydrate NOUN B-O -utilization NOUN B-O -capabilities NOUN B-O -, PUNCT B-O -we PRON B-O -defined VERB B-O -its PRON B-O -growth NOUN B-O -in ADP B-O -minimal ADJ B-LF -medium NOUN I-LF -( PUNCT B-O -MM PROPN B-AC -) PUNCT B-O -supplemented VERB B-O -with ADP B-O -one NUM B-O -of ADP B-O -46 NUM B-O -different ADJ B-O -carbohydrates NOUN B-O -[ PUNCT B-O -25 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Col-0 PROPN B-AC -, PUNCT B-O -Columbia-0 PROPN B-LF -; PUNCT B-O -CTL1 PROPN B-AC -, PUNCT B-O -choline NOUN B-LF -transporter NOUN I-LF -- PUNCT I-LF -like ADJ I-LF -1 NUM I-LF -; PUNCT B-O -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -FM4 PROPN B-AC -, PUNCT B-O -N-(3 NOUN B-LF -- PUNCT I-LF -Triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium NOUN I-LF -dibromide NOUN I-LF -; PUNCT B-O --64NRAMP1 PROPN B-AC -, PUNCT B-O -natural ADJ B-LF -resistance NOUN I-LF -- PUNCT I-LF -associated VERB I-LF -macrophage NOUN I-LF -protein NOUN I-LF -1 NUM I-LF -; PUNCT B-O -PDCB PROPN B-AC -, PUNCT B-O -plasmodesmata NOUN B-LF -callose NOUN I-LF -- PUNCT I-LF -binding VERB I-LF -protein NOUN I-LF -; PUNCT B-O -sic1 PROPN B-AC -, PUNCT B-O -significant ADJ B-LF -ionome NOUN I-LF -changes NOUN I-LF -1 NUM I-LF -. PUNCT B-O - -Line NOUN B-O -156 NUM B-O -: PUNCT B-O -‘ PUNCT B-O -Clustering VERB B-O -bootstrapping NOUN B-O -was AUX B-O -performed VERB B-O -to PART B-O -evaluate VERB B-O -the DET B-O -significance NOUN B-O -of ADP B-O -patient NOUN B-O -- NOUN B-O -specific ADJ B-O -clusters NOUN B-O -using VERB B-O -the DET B-O -pvclust NOUN B-O -R NOUN B-O -package NOUN B-O -( PUNCT B-O -1000 NUM B-O -repetitions NOUN B-O -) PUNCT B-O -and CCONJ B-O -significance NOUN B-O -were AUX B-O -estimated VERB B-O -by ADP B-O -Approximately ADV B-LF -Unbiased ADJ I-LF -( PUNCT B-O -AU PROPN B-AC -) PUNCT B-O -p NOUN B-O -- NOUN B-O -values NOUN B-O -: PUNCT B-O -Clusters NOUN B-O -were AUX B-O -considered VERB B-O -significant ADJ B-O -for ADP B-O -AU PROPN B-AC -values NOUN B-O -≥95 NUM B-O -, PUNCT B-O -which PRON B-O -indicates VERB B-O -a DET B-O -significance NOUN B-O -p NOUN B-O -- NOUN B-O -value NOUN B-O -≤0.05 NUM B-O -[ PUNCT B-O -30 NUM B-O -] PUNCT B-O -. PUNCT B-O - -’ PUNCT B-O -B X B-O -, PUNCT B-O -Anti ADJ B-O -- ADJ B-O -FXIII PROPN B-AC -autoantibody NOUN B-O -levels NOUN B-O -measured VERB B-O -using VERB B-O -ICT PROPN B-AC -( PUNCT B-O -arbitrary ADJ B-LF -unit NOUN I-LF -; PUNCT B-O -AU PROPN B-AC -) PUNCT B-O -as SCONJ B-O -described VERB B-O -in ADP B-O -“ PUNCT B-O -Materials PROPN B-O -and CCONJ B-O -Methods PROPN B-O -” PUNCT B-O -in ADP B-O -reference NOUN B-O -allele NOUN B-O -( PUNCT B-O -T NOUN B-O -/ SYM B-O -T NOUN B-O -) PUNCT B-O -, PUNCT B-O -heterozygous ADJ B-O -allele NOUN B-O -( PUNCT B-O -T NOUN B-O -/ SYM B-O -C NOUN B-O -) PUNCT B-O -and CCONJ B-O -homozygous ADJ B-O -allele NOUN B-O -( PUNCT B-O -C NOUN B-O -/ SYM B-O -C NOUN B-O -) PUNCT B-O -at ADP B-O -chromosome NOUN B-O -6 NUM B-O -; PUNCT B-O -32363816 NUM B-O -in ADP B-O -BTNL2 NOUN B-O -( PUNCT B-O -rs2076530 NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Moreover ADV B-O -, PUNCT B-O -Tau PROPN B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -also ADV B-O -known VERB B-O -as ADP B-O -microtubule NOUN B-LF -- PUNCT I-LF -associated VERB I-LF -protein NOUN I-LF -tau NOUN I-LF -( PUNCT B-O -Mapt PROPN B-AC -) PUNCT B-O -, PUNCT B-O -is AUX B-O -abundant ADJ B-O -in ADP B-O -neurons NOUN B-O -and CCONJ B-O -plays VERB B-O -a DET B-O -critical ADJ B-O -role NOUN B-O -in ADP B-O -neurodegenerative ADJ B-O -diseases NOUN B-O -. PUNCT B-O - -HDN PROPN B-AC -, PUNCT B-O -human NOUN B-LF -- PUNCT I-LF -baited VERB I-LF -double ADJ I-LF -net NOUN I-LF -trap NOUN B-O -; PUNCT B-O -HLC PROPN B-AC -, PUNCT B-O -human NOUN B-O -landing NOUN B-O -catch NOUN B-O -method NOUN B-O -. PUNCT B-O - -The DET B-O -therapeutic ADJ B-O -strategies NOUN B-O -for ADP B-O -RA PROPN B-AC -have AUX B-O -developed VERB B-O -remarkably ADV B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -treat VERB B-LF -- PUNCT I-LF -to PART I-LF -- PUNCT I-LF -target NOUN I-LF -( PUNCT B-O -T2 PROPN B-AC -) PUNCT B-O -strategy NOUN B-O -described VERB B-O -in ADP B-O -the DET B-O -European PROPN B-LF -League PROPN I-LF -Against ADP I-LF -Rheumatism PROPN I-LF -( PUNCT B-O -TEULAR PROPN B-AC -) PUNCT B-O -recommendations NOUN B-O -is AUX B-O -to PART B-O -aim VERB B-O -for ADP B-O -remission NOUN B-O -or CCONJ B-O -low ADJ B-LF -disease NOUN I-LF -activity NOUN I-LF -( PUNCT B-O -LDA PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Fluid NOUN B-LF -- PUNCT I-LF -attenuated VERB I-LF -inversion NOUN I-LF -recovery NOUN I-LF -( PUNCT B-O -FLAIR PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -principle ADJ B-O -imaging NOUN B-O -sequence NOUN B-O -for ADP B-O -assessment NOUN B-O -of ADP B-O -growth NOUN B-O -of ADP B-O -low ADJ B-O -- PUNCT B-O -grade NOUN B-O -gliomas NOUN B-O -[ PUNCT B-O -4 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -the DET B-O -present ADJ B-O -study NOUN B-O -, PUNCT B-O -by ADP B-O -generating VERB B-O -new ADJ B-O -recombinant ADJ B-O -chromosomes NOUN B-LF -, PUNCT B-O -we PRON B-O -have AUX B-O -been AUX B-O -able ADJ B-O -to PART B-O -locate VERB B-O -the DET B-O -genetic ADJ B-O -element NOUN B-O -responsible ADJ B-O -for ADP B-O -Psmb9 NOUN B-O -activity NOUN B-O -within ADP B-O -6.7 NUM B-O -Mb NOUN B-O -on ADP B-O -Chr PROPN B-AC -17 NUM B-O -. PUNCT B-O - -We PRON B-O -found VERB B-O -that SCONJ B-O -each DET B-O -point NOUN B-O -increase NOUN B-O -in ADP B-O -QFPC PROPN B-AC -, PUNCT B-O -including VERB B-O -increasing VERB B-O -quality NOUN B-O -of ADP B-O -counselling NOUN B-O -, PUNCT B-O -is AUX B-O -associated VERB B-O -with ADP B-O -higher ADJ B-O -odds NOUN B-O -of ADP B-O -clients NOUN B-O -selecting VERB B-O -an DET B-O -intrauterine ADJ B-LF -device NOUN I-LF -( PUNCT B-O -IUD PROPN B-AC -) PUNCT B-O -( PUNCT B-O -aRR:1.03 PROPN B-AC -; PUNCT B-O -95 NUM B-O -% NOUN B-O -CI:1.01–1.05 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -sterilization NOUN B-O -( PUNCT B-O -aRR:1.06 PROPN B-AC -; PUNCT B-O -95 NUM B-O -% NOUN B-O -CI:1.03–1.08 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -compared VERB B-O -to ADP B-O -no DET B-O -method NOUN B-O -selected VERB B-O -. PUNCT B-O - -The DET B-O -aim NOUN B-O -of ADP B-O -the DET B-O -present ADJ B-O -study NOUN B-O -was AUX B-O -to PART B-O -investigate VERB B-O -the DET B-O -association NOUN B-O -between ADP B-O -the DET B-O -functional ADJ B-O -ITPA PROPN B-AC -variants NOUN B-O -and CCONJ B-O -hematological ADJ B-O -side NOUN B-O -effects NOUN B-O -during ADP B-O -antiviral ADJ B-O -therapy NOUN B-O -with ADP B-O -pegylated ADJ B-LF -interferon NOUN I-LF -( PUNCT B-O -PegIFN PROPN B-AC -) PUNCT B-O -and CCONJ B-O -RBV PROPN B-AC -. PUNCT B-O - -Ressing PROPN B-O -, PUNCT B-O -Leiden PROPN B-O -University PROPN B-O -Medical PROPN B-O -Center PROPN B-O -, PUNCT B-O -the DET B-O -Netherlands PROPN B-O -[ PUNCT B-O -35 NUM B-O -] PUNCT B-O -) PUNCT B-O -were AUX B-O -cultured VERB B-O -in ADP B-O -Roswell PROPN B-LF -Park PROPN I-LF -Memorial PROPN I-LF -Institute PROPN I-LF -( PUNCT B-O -RPMI PROPN B-AC -) PUNCT B-O -medium NOUN B-O -( PUNCT B-O -Gibco PROPN B-O -) PUNCT B-O -supplemented VERB B-O -with ADP B-O -10 NUM B-O -% NOUN B-O -( PUNCT B-O -v NOUN B-O -/ SYM B-O -v NOUN B-O -) PUNCT B-O -FBS PROPN B-AC -, PUNCT B-O -2 NUM B-O -mM PROPN B-O -GlutaMAX PROPN B-O -, PUNCT B-O -1 NUM B-O -% NOUN B-O -( PUNCT B-O -v NOUN B-O -/ SYM B-O -v NOUN B-O -) PUNCT B-O -Pen PROPN B-O -- PUNCT B-O -Strep PROPN B-O -, PUNCT B-O -and CCONJ B-O -0.3 NUM B-O -mg NOUN B-O -/ SYM B-O -mL NOUN B-O -hygromycin NOUN B-O -B. NOUN B-O -A DET B-O -new ADJ B-O -release NOUN B-O -of ADP B-O -XPDF PROPN B-AC -( PUNCT B-O -a DET B-LF -PDF NOUN I-LF -viewer NOUN I-LF -for ADP I-LF -X PROPN I-LF -; PUNCT B-O -http://www.foolabs.com/xpdf/ X B-O -) PUNCT B-O -eases VERB B-O -this DET B-O -problem NOUN B-O -considerably ADV B-O -( PUNCT B-O -see VERB B-O -Materials PROPN B-O -and CCONJ B-O -Methods PROPN B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -rodent NOUN B-O -models NOUN B-O -of ADP B-O -chronic ADJ B-O -inflammatory ADJ B-O -and CCONJ B-O -neuropathic ADJ B-O -pain NOUN B-O -, PUNCT B-O -there PRON B-O -is VERB B-O -a DET B-O -male NOUN B-O -- PUNCT B-O -specific ADJ B-O -activation NOUN B-O -of ADP B-O -microglial ADJ B-O -signaling NOUN B-O -in ADP B-O -the DET B-O -spinal ADJ B-O -cord NOUN B-O -, PUNCT B-O -which PRON B-O -includes VERB B-O -the DET B-O -up NOUN B-O -- PUNCT B-O -regulation NOUN B-O -of ADP B-O -P2X4 NOUN B-O -receptors NOUN B-O -[ PUNCT B-O -38 NUM B-O -] PUNCT B-O -, PUNCT B-O -phosphorylation NOUN B-O -of ADP B-O -p38−mitogen NOUN B-O -- PUNCT I-LF -activated VERB I-LF -protein NOUN I-LF -kinase NOUN I-LF -( PUNCT B-O -MAPK PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -39 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -subsequent ADJ B-O -synthesis NOUN B-O -and CCONJ B-O -release NOUN B-O -of ADP B-O -BDNF PROPN B-AC -[ PUNCT B-O -20 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This DET B-O -newly ADV B-O -evolved VERB B-O -cell NOUN B-O -type NOUN B-O -is AUX B-O -rigidly ADV B-O -specified VERB B-O -early ADV B-O -in ADP B-O -development NOUN B-O -through ADP B-O -the DET B-O -activity NOUN B-O -of ADP B-O -localized VERB B-O -maternal ADJ B-O -factors NOUN B-O -and CCONJ B-O -deploys VERB B-O -a DET B-O -well ADV B-O -- PUNCT B-O -characterized VERB B-O -gene NOUN B-LF -regulatory ADJ I-LF -network NOUN I-LF -( PUNCT B-O -GRN PROPN B-AC -) PUNCT B-O -that PRON B-O -controls VERB B-O -the DET B-O -morphogenetic ADJ B-O -behaviors NOUN B-O -and CCONJ B-O -biomineral NOUN B-O -- PUNCT B-O -forming VERB B-O -properties NOUN B-O -of ADP B-O -PMCs PROPN B-AC -[ X B-O -1–3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Calreticulin NOUN B-LF -( PUNCT B-O -CRT PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -multifunctional ADJ B-O -stress NOUN B-O -- PUNCT B-O -response NOUN B-O -chaperone NOUN B-O -residing VERB B-O -mainly ADV B-O -in ADP B-O -the DET B-O -lumen NOUN B-O -of ADP B-O -the DET B-O -endoplasmic ADJ B-LF -reticulum NOUN I-LF -( PUNCT B-O -ER PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -cell NOUN B-O -with ADP B-O -the DET B-O -ability NOUN B-O -to PART B-O -control VERB B-O -proper ADJ B-O -protein NOUN B-O -folding NOUN B-O -and CCONJ B-O -regulate VERB B-O -cellular ADJ B-O -adhesion NOUN B-O -[ PUNCT B-O -1–6 NUM B-O -] PUNCT B-O -. PUNCT B-O - -We PRON B-O -have AUX B-O -previously ADV B-O -reported VERB B-O -that SCONJ B-O -the DET B-O -structure NOUN B-O -and CCONJ B-O -composition NOUN B-O -of ADP B-O -HF PROPN B-AC -- PUNCT B-O -released VERB B-O -secondary ADJ B-LF -cell NOUN I-LF -wall NOUN I-LF -polysaccharides NOUN I-LF -( PUNCT B-O -HF PROPN B-AC -) PUNCT B-O -from ADP B-O -Ba PROPN B-O -vegetative ADJ B-O -cells NOUN B-O -are AUX B-O -not PART B-O -dependent ADJ B-O -on ADP B-O -plasmid NOUN B-O -content NOUN B-O -[ X B-O -11 NUM B-O -] PUNCT B-O -, PUNCT B-O -are AUX B-O -specific ADJ B-O -for ADP B-O -Ba PROPN B-O -and CCONJ B-O -antigenic ADJ B-O -[ X B-O -12–14 NUM B-O -] PUNCT B-O -. PUNCT B-O - -PDCD10 PROPN B-AC -complexes NOUN B-O -with ADP B-O -CCM1 PROPN B-O -( PUNCT B-O -Krev PROPN B-LF -/ SYM I-LF -Rap1 PROPN I-LF -Interacting PROPN I-LF -Trapped PROPN I-LF -1 NUM I-LF -[ PUNCT B-O -KRIT1 PROPN B-AC -] PUNCT B-O -) PUNCT B-O -and CCONJ B-O -CCM2 PROPN B-O -( PUNCT B-O -osmosensing VERB B-LF -scaffold NOUN I-LF -for ADP I-LF -mitogen NOUN I-LF -- PUNCT I-LF -activated VERB I-LF -protein NOUN I-LF -kinase NOUN I-LF -kinase NOUN I-LF -kinase-3 NOUN I-LF -[ PUNCT B-O -OSM PROPN B-AC -] PUNCT B-O -) PUNCT B-O -to PART B-O -control VERB B-O -the DET B-O -onset NOUN B-O -of ADP B-O -a DET B-O -detrimental ADJ B-O -disease NOUN B-O -named VERB B-O -CCM PROPN B-AC -. PUNCT B-O - -CCM PROPN B-AC -is AUX B-O -characterized VERB B-O -by ADP B-O -vascular ADJ B-O -lesions NOUN B-O -in ADP B-O -the DET B-O -central ADJ B-O -nervous ADJ B-O -system NOUN B-O -[ PUNCT B-O -14 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -Simes PROPN B-O -multiple ADJ B-O -- NOUN B-O -test NOUN B-O -procedure NOUN B-O -was AUX B-O -used VERB B-O -for ADP B-O -controlling VERB B-O -the DET B-O -false ADJ B-LF -discovery NOUN I-LF -rate NOUN I-LF -( PUNCT B-O -FDR PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -SNP PROPN B-AC -rs848 NUM B-O -in ADP B-O -the DET B-O -IL13 NUM B-O -gene NOUN B-O -region NOUN B-O -( PUNCT B-O -IL5 NOUN B-O -/ SYM B-O -RAD50 NOUN B-O -/ SYM B-O -IL13 NUM B-O -/ SYM B-O -IL4 NUM B-O -) PUNCT B-O -was AUX B-O -associated VERB B-O -with ADP B-O -STS PROPN B-AC -( PUNCT B-O -TG NOUN B-O -/ SYM B-O -GG NOUN B-O -vs ADP B-O -TT PROPN B-O -genotype NOUN B-O -: PUNCT B-O -uncorrected ADJ B-O -p NOUN B-O -- NOUN B-O -value NOUN B-O -= SYM B-O -0.00006 NUM B-O -, PUNCT B-O -FDR PROPN B-AC -- NOUN B-O -corrected VERB B-O -p NOUN B-O -- NOUN B-O -value NOUN B-O -= SYM B-O -0.04 NUM B-O -) PUNCT B-O -, PUNCT B-O -whereas SCONJ B-O -rs20541 NOUN B-O -in ADP B-O -the DET B-O -same ADJ B-O -gene NOUN B-O -region NOUN B-O -, PUNCT B-O -in ADP B-O -linkage NOUN B-O -disequilibrium NOUN B-O -with ADP B-O -rs848 NUM B-O -( PUNCT B-O -r2 NOUN B-O -= SYM B-O -0.94 NUM B-O -) PUNCT B-O -in ADP B-O -our PRON B-O -sample NOUN B-O -, PUNCT B-O -did AUX B-O -not PART B-O -reach VERB B-O -the DET B-O -statistical ADJ B-O -significance NOUN B-O -after ADP B-O -adjusting VERB B-O -for ADP B-O -multiple ADJ B-O -testing NOUN B-O -( PUNCT B-O -TC NOUN B-O -/ SYM B-O -CC NOUN B-O -vs ADP B-O -TT PROPN B-O -: PUNCT B-O -uncorrected ADJ B-O -p NOUN B-O -- NOUN B-O -value NOUN B-O -= SYM B-O -0.0003 NUM B-O -, PUNCT B-O -FDR PROPN B-AC -- NOUN B-O -corrected VERB B-O -p NOUN B-O -- NOUN B-O -value NOUN B-O -= SYM B-O -0.09 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Eukaryotic ADJ B-O -genomes NOUN B-O -contain VERB B-O -large ADJ B-O -quantities NOUN B-O -of ADP B-O -transposable ADJ B-LF -elements NOUN I-LF -( PUNCT B-O -TEs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -short ADJ B-O -self NOUN B-O -- PUNCT B-O -replicating VERB B-O -DNA NOUN B-O -sequences NOUN B-O -that PRON B-O -can AUX B-O -move VERB B-O -within ADP B-O -the DET B-O -genome NOUN B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -criteria NOUN B-O -aPL PROPN B-AC -( PUNCT B-O -aCL PROPN B-AC -and CCONJ B-O -aβ2-GPI PROPN B-AC -IgG NOUN B-O -and CCONJ B-O -IgM NOUN B-O -) PUNCT B-O -were AUX B-O -determined VERB B-O -with SCONJ B-O -four NUM B-O -well ADV B-O -- PUNCT B-O -established VERB B-O -immunoassay NOUN B-O -systems NOUN B-O -in ADP B-O -all PRON B-O -included VERB B-O -sera NOUN B-O -: PUNCT B-O -ALE PROPN B-AC -, PUNCT B-O -ACU PROPN B-AC -, PUNCT B-O -UniCAP PROPN B-LF -250 NUM I-LF -( PUNCT B-O -UNI PROPN B-AC -) PUNCT B-O -from ADP B-O -Thermo PROPN B-O -Fisher PROPN B-O -Scientific PROPN B-O -( PUNCT B-O -Freiburg PROPN B-O -, PUNCT B-O -Germany PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -AESKULISA PROPN B-LF -( PUNCT B-O -AES PROPN B-AC -) PUNCT B-O -from ADP B-O -Aesku.diagnostics PROPN B-O -( PUNCT B-O -Wendelsheim PROPN B-O -, PUNCT B-O -Germany PROPN B-O -) PUNCT B-O -. PUNCT B-O - -First ADV B-O -, PUNCT B-O -during ADP B-O -data NOUN B-O -preprocessing NOUN B-O -, PUNCT B-O -we PRON B-O -removed VERB B-O -oculomotor NOUN B-O -artefacts NOUN B-O -via ADP B-O -independent ADJ B-LF -component NOUN I-LF -analysis NOUN I-LF -( PUNCT B-O -ICA PROPN B-AC -) PUNCT B-O -( PUNCT B-O -see VERB B-O -S1 PROPN B-O -Text NOUN B-O -) PUNCT B-O -; PUNCT B-O -second X B-O -, PUNCT B-O -we PRON B-O -have AUX B-O -only ADV B-O -reported VERB B-O -data NOUN B-O -in ADP B-O -this DET B-O -paper NOUN B-O -from ADP B-O -two NUM B-O -channels NOUN B-O -near ADP B-O -the DET B-O -vertex NOUN B-O -— PUNCT B-O -C3 NOUN B-O -and CCONJ B-O -C4 NOUN B-O -, PUNCT B-O -which PRON B-O -show VERB B-O -the DET B-O -least ADJ B-O -contamination NOUN B-O -by ADP B-O -muscle NOUN B-O -and CCONJ B-O -motion NOUN B-O -artefacts NOUN B-O -. PUNCT B-O - -( PUNCT B-O -See VERB B-O -S5 PROPN B-O -and CCONJ B-O -S6 PROPN B-O -Figs NOUN B-O -for ADP B-O -comparable ADJ B-O -plots NOUN B-O -of ADP B-O -anterior ADJ B-O -and CCONJ B-O -posterior ADJ B-O -midline NOUN B-O -groups NOUN B-O -. PUNCT B-O - -) PUNCT B-O -Third X B-O -, PUNCT B-O -the DET B-O -cross ADJ B-O -- NOUN B-O -correlation NOUN B-O -analysis NOUN B-O -across ADP B-O -different ADJ B-O -frequencies NOUN B-O -( PUNCT B-O -Fig NOUN B-O -2A NUM B-O -) PUNCT B-O -indicated VERB B-O -that SCONJ B-O -relationships NOUN B-O -were AUX B-O -specific ADJ B-O -to ADP B-O -the DET B-O -theta NOUN B-O -band NOUN B-O -. PUNCT B-O - -Prostate ADJ B-LF -- PUNCT I-LF -Specific ADJ I-LF -Antigen NOUN I-LF -( PUNCT I-LF -PSA PROPN I-LF -In ADP B-O -principle NOUN B-O -, PUNCT B-O -it PRON B-O -can AUX B-O -occur VERB B-O -via ADP B-O -any DET B-O -1 NUM B-O -of ADP B-O -3 NUM B-O -mechanisms NOUN B-O -of ADP B-O -homologous ADJ B-LF -recombination NOUN I-LF -( PUNCT B-O -HR PROPN B-AC -): PUNCT B-O -canonical ADJ B-O -DSB PROPN B-LF -repair NOUN I-LF -DSB PROPN B-AC -( PUNCT B-O -DSBR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -synthesis NOUN B-LF -- PUNCT I-LF -dependent ADJ I-LF -strand NOUN I-LF -annealing NOUN I-LF -( PUNCT B-O -SDSA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -break NOUN B-LF -- PUNCT I-LF -induced VERB I-LF -replication NOUN I-LF -( PUNCT B-O -BIR PROPN B-AC -) PUNCT B-O -( PUNCT B-O -reviewed VERB B-O -in ADP B-O -[ X B-O -21,22 NUM B-O -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -Coverage NOUN B-O -estimates NOUN B-O -are AUX B-O -generally ADV B-O -obtained VERB B-O -from ADP B-O -routine ADJ B-O -population NOUN B-O -- PUNCT B-O -based VERB B-O -household NOUN B-O -surveys NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -the DET B-O -Demographic PROPN B-O -and CCONJ B-O -Health PROPN B-O -Surveys PROPN B-O -( PUNCT B-O -DHS PROPN B-AC -) PUNCT B-O -and CCONJ B-O -the DET B-O -Multiple PROPN B-LF -Indicator PROPN I-LF -Cluster PROPN I-LF -Surveys PROPN I-LF -( PUNCT B-O -MICS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -primarily ADV B-O -through ADP B-O -self NOUN B-O -- PUNCT B-O -reporting NOUN B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -We PRON B-O -named VERB B-O -these PRON B-O -long ADJ B-O -expressed VERB B-LF -noncoding NOUN I-LF -regions NOUN I-LF -( PUNCT B-O -ENORs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -clinical ADJ B-O -implication NOUN B-O -of ADP B-O -AF PROPN B-AC -is AUX B-O -that SCONJ B-O -it PRON B-O -is AUX B-O -associated VERB B-O -with ADP B-O -an DET B-O -increased VERB B-O -risk NOUN B-O -of ADP B-O -stroke NOUN B-O -, PUNCT B-O -heart NOUN B-LF -failure NOUN I-LF -( PUNCT B-O -HF PROPN B-AC -) PUNCT B-O -, PUNCT B-O -myocardial ADJ B-LF -infarction NOUN I-LF -( PUNCT B-O -MI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -death NOUN B-O -[ X B-O -2,4 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -primary ADJ B-O -endpoint NOUN B-O -was AUX B-O -clinical ADJ B-O -benefit NOUN B-O -( PUNCT B-O -defined VERB B-O -as ADP B-O -stable ADJ B-LF -disease NOUN I-LF -[ PUNCT B-O -SD PROPN B-AC -] PUNCT B-O -for ADP B-O -≥6 NUM B-O -mo NOUN B-O -, PUNCT B-O -partial ADJ B-LF -response NOUN I-LF -[ PUNCT B-O -PR PROPN B-AC -] PUNCT B-O -, PUNCT B-O -or CCONJ B-O -complete ADJ B-LF -response NOUN I-LF -[ PUNCT B-O -CR PROPN B-AC -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -True ADJ B-LF -skill NOUN I-LF -statistic NOUN I-LF -( PUNCT B-O -TSS PROPN B-AC -) PUNCT B-O -was AUX B-O -used VERB B-O -as ADP B-O -a DET B-O -measure NOUN B-O -of ADP B-O -the DET B-O -model NOUN B-O -quality NOUN B-O -, PUNCT B-O -since SCONJ B-O -it PRON B-O -was AUX B-O -a DET B-O -default ADJ B-O -measure NOUN B-O -in ADP B-O -BIOMOD PROPN B-O -2.1.37 NUM B-O -[ PUNCT B-O -52 NUM B-O -] PUNCT B-O -. PUNCT B-O - -A DET B-O -971 NUM B-O -- PUNCT B-O -bp PROPN B-AC -probe NOUN B-O -revealed VERB B-O -DNA NOUN B-O -rearrangements NOUN B-O -, PUNCT B-O -refining VERB B-O -the DET B-O -breakpoint NOUN B-O -to ADP B-O -a DET B-O -4.7 NUM B-O -- PUNCT B-O -kilobase NOUN B-LF -( PUNCT B-O -kb PROPN B-AC -) PUNCT B-O -interval NOUN B-O -on ADP B-O -the DET B-O -Celera PROPN B-O -scaffold NOUN B-O -sequence NOUN B-O -or CCONJ B-O -a DET B-O -4.0 NUM B-O -- PUNCT B-O -kb PROPN B-AC -interval NOUN B-O -corresponding VERB B-O -to ADP B-O -nucleotides NOUN B-O -57269–61233 NUM B-O -of ADP B-O -BAC PROPN B-AC -AC117479 NUM B-O -( PUNCT B-O -Figure NOUN B-O -1B NUM B-O -and CCONJ B-O -1D NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Surprisingly ADV B-O -, PUNCT B-O -the DET B-O -translocation NOUN B-O -breakpoint NOUN B-O -localized VERB B-O -within ADP B-O -the DET B-O -ortholog NOUN B-O -of ADP B-O -the DET B-O -Drosophila PROPN B-O -roundabout NOUN B-O -( PUNCT B-O -robo NOUN B-O -) PUNCT B-O -gene NOUN B-O -, PUNCT B-O -ROBO1 NOUN B-O -, PUNCT B-O -alternatively ADV B-O -spliced VERB B-O -and CCONJ B-O -also ADV B-O -named VERB B-O -DUTT1 PROPN B-O -( PUNCT B-O -Deleted VERB B-O -in ADP B-O -U PROPN B-O -Twenty PROPN B-O -Twenty PROPN B-O -) PUNCT B-O -, PUNCT B-O -disrupts VERB B-O -ROBO1 NOUN B-O -between ADP B-O -exons NOUN B-O -1 NUM B-O -and CCONJ B-O -2 NUM B-O -. PUNCT B-O - -Known VERB B-O -risk NOUN B-O -factors NOUN B-O -for ADP B-O -mild ADJ B-O -CI PROPN B-AC -include VERB B-O -increased VERB B-O -age NOUN B-O -and CCONJ B-O -genetic ADJ B-O -susceptibility NOUN B-O -[ X B-O -1 NUM B-O -, PUNCT B-O -17 NUM B-O -] X B-O -while SCONJ B-O -cardiovascular ADJ B-O -disease NOUN B-O -( PUNCT B-O -high ADJ B-O -blood NOUN B-O -pressure NOUN B-O -and CCONJ B-O -stroke NOUN B-O -) PUNCT B-O -, PUNCT B-O -diabetes NOUN B-O -, PUNCT B-O -depression NOUN B-O -/ SYM B-O -anxiety NOUN B-O -, PUNCT B-O -tobacco NOUN B-O -smoking NOUN B-O -and CCONJ B-O -social ADJ B-O -factors NOUN B-O -( PUNCT B-O -e.g. X B-O -, PUNCT B-O -lack NOUN B-O -of ADP B-O -relationships NOUN B-O -with ADP B-O -others NOUN B-O -and CCONJ B-O -a DET B-O -community NOUN B-O -, PUNCT B-O -lack NOUN B-O -of ADP B-O -physical ADJ B-O -activity NOUN B-O -, PUNCT B-O -and CCONJ B-O -low ADJ B-O -socio ADJ B-LF -- ADJ I-LF -economic ADJ I-LF -status NOUN I-LF -( PUNCT B-O -SES PROPN B-AC -) PUNCT B-O -) PUNCT B-O -[ X B-O -1 NUM B-O -, PUNCT B-O -17 NUM B-O -, PUNCT B-O -18 NUM B-O -] X B-O -are AUX B-O -reported VERB B-O -as ADP B-O -possible ADJ B-O -risk NOUN B-O -factors NOUN B-O -. PUNCT B-O - -DN PROPN B-AC -, PUNCT B-O -dominant NOUN B-LF -- PUNCT I-LF -negative ADJ I-LF -; PUNCT B-O -EC PROPN B-AC -, PUNCT B-O -endothelial ADJ B-LF -cell NOUN I-LF -; PUNCT B-O -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -hpf PROPN B-AC -, PUNCT B-O -hours NOUN B-LF -post ADP I-LF -fertilization NOUN I-LF -; PUNCT B-O -HS PROPN B-AC -, PUNCT B-O -heat NOUN B-LF -shock NOUN I-LF -; PUNCT B-O -HSPC PROPN B-AC -, PUNCT B-O -hematopoietic ADJ B-LF -stem NOUN I-LF -and CCONJ I-LF -progenitor NOUN I-LF -cell NOUN I-LF -; PUNCT B-O -NICD PROPN B-AC -, PUNCT B-O -Notch PROPN B-LF -intracellular ADJ I-LF -domain NOUN I-LF -; PUNCT B-O -n.s NOUN B-O -. PUNCT B-O - -, PUNCT B-O -nonsignificant ADJ B-O -; PUNCT B-O -qRT PROPN B-AC -, PUNCT B-O -quantitative ADJ B-LF -reverse ADJ I-LF -- PUNCT I-LF -transcription ADJ I-LF -PCR NOUN I-LF -; PUNCT B-O -WB PROPN B-O -, PUNCT B-O -western ADJ B-O -blot NOUN B-O -; PUNCT B-O --PCRWISH PROPN B-AC -, PUNCT B-O -whole ADJ B-LF -- PUNCT I-LF -mount NOUN I-LF -in ADP I-LF -situ NOUN I-LF -hybridization NOUN I-LF -When SCONJ B-O -we PRON B-O -assessed VERB B-O -the DET B-O -presence NOUN B-O -of ADP B-O -inflammation NOUN B-O -in ADP B-O -the DET B-O -CNS PROPN B-AC -of ADP B-O -Nlrx1−/− PROPN B-O -2D2 PROPN B-O -spEAE PROPN B-AC -mice NOUN B-O -, PUNCT B-O -we PRON B-O -found VERB B-O -that SCONJ B-O -the DET B-O -lack NOUN B-O -of ADP B-O -NLRX1 PROPN B-AC -did AUX B-O -not PART B-O -affect VERB B-O -the DET B-O -expression NOUN B-O -of ADP B-O -glial ADJ B-LF -fibrillary NOUN I-LF -acidic ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -GFAP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -ionized VERB B-LF -calcium NOUN I-LF -binding VERB I-LF -adaptor NOUN I-LF -molecule NOUN I-LF -1(Iba1 PROPN I-LF -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -myelin NOUN B-LF -basic ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -MBP PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -spinal ADJ B-O -cords NOUN B-O -of ADP B-O -healthy ADJ B-O -Nlrx1−/− PROPN B-O -2D2 PROPN B-O -mice NOUN B-O -( PUNCT B-O -S1A PROPN B-O -Fig PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Our PRON B-O -method NOUN B-O -was AUX B-O -highly ADV B-O -predictive ADJ B-O -of ADP B-O -transcription NOUN B-LF -start NOUN I-LF -sites NOUN I-LF -( PUNCT B-O -TSSs PROPN B-AC -) PUNCT B-O -in ADP B-O -S. PROPN B-O -cerevisiae NOUN B-O -[ X B-O -50]—the X B-O -NFR PROPN B-O -boundary NOUN B-O -closest ADJ B-O -to PART B-O -the DET B-O -5′ NUM B-O -end NOUN B-O -of ADP B-O -the DET B-O -gene NOUN B-O -was AUX B-O -able ADJ B-O -to PART B-O -predict VERB B-O -84 NUM B-O -% NOUN B-O -of ADP B-O -TSSs PROPN B-AC -within ADP B-O -50 NUM B-O -bp NOUN B-O -. PUNCT B-O - -Several ADJ B-O -lines NOUN B-O -of ADP B-O -evidence NOUN B-O -suggest VERB B-O -that SCONJ B-O -histone NOUN B-O -variants NOUN B-O -and CCONJ B-O -their PRON B-O -covalent ADJ B-O -post ADJ B-LF -- ADJ I-LF -translational ADJ I-LF -modifications NOUN I-LF -( PUNCT B-O -PTMs PROPN B-AC -) PUNCT B-O -play VERB B-O -a DET B-O -key ADJ B-O -role NOUN B-O -in ADP B-O -developmental ADJ B-O -processes NOUN B-O -such ADJ B-O -as ADP B-O -the DET B-O -initiation NOUN B-O -and CCONJ B-O -maintenance NOUN B-O -of ADP B-O -pericentric ADJ B-O -heterochromatin NOUN B-O -, PUNCT B-O -X NOUN B-O -chromosome NOUN B-O -inactivation NOUN B-O -, PUNCT B-O -and CCONJ B-O -germ NOUN B-O -cell NOUN B-O -differentiation NOUN B-O -[ PUNCT B-O -4 NUM B-O -, PUNCT B-O -11 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Regarding VERB B-O -the DET B-O -biological ADJ B-O -aspect NOUN B-O -, PUNCT B-O -carbon NOUN B-O -ion NOUN B-O -beams NOUN B-O -have VERB B-O -an DET B-O -estimated VERB B-O -2–3 NUM B-O -- NOUN B-O -fold ADJ B-O -higher ADJ B-O -relative ADJ B-LF -biological ADJ I-LF -effectiveness NOUN I-LF -( PUNCT B-O -RBE PROPN B-AC -) PUNCT B-O -than ADP B-O -X NOUN B-O -- NOUN B-O -rays NOUN B-O -[ PUNCT B-O -8 NUM B-O -, PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -order NOUN B-O -to PART B-O -determine VERB B-O -the DET B-O -mechanical ADJ B-O -properties NOUN B-O -of ADP B-O -the DET B-O -bone NOUN B-O -material NOUN B-O -, PUNCT B-O -the DET B-O -fourth ADJ B-O -caudal ADJ B-O -vertebrae NOUN B-O -of ADP B-O -6 NUM B-O -medaka NOUN B-O -( PUNCT B-O -3 NUM B-O -controls NOUN B-O -and CCONJ B-O -3 NUM B-O -swim NOUN B-O -- PUNCT B-O -trained VERB B-O -fish NOUN B-O -) PUNCT B-O -and CCONJ B-O -6 NUM B-O -zebrafish NOUN B-O -( PUNCT B-O -3 NUM B-O -controls NOUN B-O -and CCONJ B-O -3 NUM B-O -swim NOUN B-O -- PUNCT B-O -trained VERB B-O -fish NOUN B-O -) PUNCT B-O -were AUX B-O -dehydrated VERB B-O -with ADP B-O -increasing VERB B-O -concentrations NOUN B-O -of ADP B-O -ethanol NOUN B-O -and CCONJ B-O -embedded VERB B-O -for ADP B-O -8 NUM B-O -hours NOUN B-O -in ADP B-O -polymethylmethacrylate NOUN B-LF -( PUNCT B-O -PMMA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -was AUX B-O -polymerized VERB B-O -in ADP B-O -an DET B-O -oven NOUN B-O -at ADP B-O -60 NUM B-O -° NOUN B-O -C NOUN B-O -. PUNCT B-O - -As SCONJ B-O -earlier ADV B-O -reported VERB B-O -, PUNCT B-O -Ace PROPN B-AC -protein NOUN B-O -had AUX B-O -been AUX B-O -modelled VERB B-O -using VERB B-O -a DET B-O -template NOUN B-O -structure NOUN B-O -, PUNCT B-O -zhaoermiatoxin NOUN B-O -from ADP B-O -Zhaoermia PROPN B-O -mangshanensis NOUN B-O -[ PUNCT B-O -Protein PROPN B-LF -Data PROPN I-LF -Bank PROPN I-LF -( PUNCT B-O -PDB PROPN B-AC -) NOUN B-O -entry NOUN B-O -2PH4 NOUN B-O -] PUNCT B-O -, PUNCT B-O -a DET B-O -dimeric ADJ B-O -toxin NOUN B-O -which PRON B-O -showed VERB B-O -reasonable ADJ B-O -sequence NOUN B-O -similarity NOUN B-O -( PUNCT B-O -45 NUM B-O -% NOUN B-O -) NOUN B-O -with ADP B-O -the DET B-O -target NOUN B-O -[ PUNCT B-O -7 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Both DET B-O -trials NOUN B-O -recruited VERB B-O -postally ADV B-O -from ADP B-O -primary ADJ B-O -care NOUN B-O -and CCONJ B-O -delivered VERB B-O -12 NUM B-O -- PUNCT B-O -week NOUN B-O -pedometer NOUN B-O -- PUNCT B-O -based VERB B-O -walking NOUN B-O -interventions NOUN B-O -incorporating VERB B-O -behaviour NOUN B-LF -change NOUN I-LF -techniques NOUN I-LF -( PUNCT B-O -BCTs PROPN B-AC -) PUNCT B-O -through ADP B-O -dedicated ADJ B-O -practice NOUN B-O -nurse NOUN B-O -PA PROPN B-AC -consultations NOUN B-O -( PUNCT B-O -3 NUM B-O -in ADP B-O -PACE PROPN B-AC -, PUNCT B-O -4 NUM B-O -in ADP B-O --UPPACE PROPN B-AC -) PUNCT B-O -or CCONJ B-O -by ADP B-O -post NOUN B-O -( PUNCT B-O --LiftPACE PROPN B-AC -only ADV B-O -) PUNCT B-O -. PUNCT B-O - -DAS28-ESR PROPN B-AC -, PUNCT B-O -Disease PROPN B-LF -Activity PROPN I-LF -Score–28 NUM I-LF -with ADP I-LF -erythrocyte NOUN I-LF -sedimentation NOUN I-LF -rate NOUN I-LF -; PUNCT B-O -Early ADJ B-O -, PUNCT B-O -early ADJ B-O -treatment NOUN B-O -; PUNCT B-O -HAQ PROPN B-AC -, PUNCT B-O -Health PROPN B-LF -Assessment PROPN I-LF -Questionnaire NOUN I-LF -; PUNCT B-O -NSAID PROPN B-O -, PUNCT B-O -nonsteroidal ADJ B-O -anti ADJ B-O -- PUNCT B-O -inflammatory ADJ B-O -drug NOUN B-O -; PUNCT B-O -MTX PROPN B-O -, PUNCT B-O -methotrexate NOUN B-O -; PUNCT B-O -noMTX PROPN B-O -, PUNCT B-O -no DET B-O -methotrexate NOUN B-O -; PUNCT B-O -RA PROPN B-AC -, PUNCT B-O -rheumatoid ADJ B-LF -arthritis NOUN I-LF -; PUNCT B-O -SDFR PROPN B-AC -, PUNCT B-O -sustained VERB B-LF -DMARD NOUN I-LF -- PUNCT I-LF -DMARD PROPN B-AC -free ADJ I-LF -remission NOUN I-LF -; PUNCT B-O -T2 PROPN B-O -T PROPN B-O -, PUNCT B-O -treat VERB B-O -- PUNCT B-O -to ADP B-O -- PUNCT B-O -target NOUN B-O -. PUNCT B-O - -Behavioral ADJ B-O -factors NOUN B-O -defined VERB B-O -by ADP B-O -the DET B-O -Kenya PROPN B-O -PrEP PROPN B-AC -guidelines NOUN B-O -to PART B-O -indicate VERB B-O -a DET B-O -substantial ADJ B-O -ongoing ADJ B-O -risk NOUN B-O -of ADP B-O -acquiring VERB B-O -HIV PROPN B-O -include VERB B-O -the DET B-O -following VERB B-O -: PUNCT B-O -( PUNCT B-O -a DET B-O -) PUNCT B-O -inconsistent ADJ B-O -or CCONJ B-O -no PRON B-O -condom NOUN B-O -use NOUN B-O -in ADP B-O -the DET B-O -last ADJ B-O -6 NUM B-O -months NOUN B-O -; PUNCT B-O -( PUNCT B-O -b X B-O -) PUNCT B-O -having VERB B-O -a DET B-O -high ADJ B-O -- PUNCT B-O -risk NOUN B-O -sex NOUN B-O -partner(s NOUN B-O -) PUNCT B-O -of ADP B-O -unknown ADJ B-O -HIV PROPN B-O -status NOUN B-O -; PUNCT B-O -( PUNCT B-O -c X B-O -) PUNCT B-O -engaging VERB B-O -in ADP B-O -transactional ADJ B-O -sex NOUN B-O -; PUNCT B-O -( PUNCT B-O -d X B-O -) PUNCT B-O -history NOUN B-O -of ADP B-O -ongoing ADJ B-O -intimate ADJ B-LF -partner NOUN I-LF -violence NOUN I-LF -( PUNCT B-O -IPV PROPN B-AC -) PUNCT B-O -and CCONJ B-O -gender NOUN B-LF -- PUNCT I-LF -based VERB I-LF -violence NOUN I-LF -( PUNCT B-O -GBV PROPN B-AC -) PUNCT B-O -; PUNCT B-O -( PUNCT B-O -e X B-O -) PUNCT B-O -recent ADJ B-O -bacterial ADJ B-O -STIs PROPN B-AC -, PUNCT B-O -self NOUN B-O -- PUNCT B-O -reported VERB B-O -or CCONJ B-O -etiologically ADV B-O -diagnosed VERB B-O -; PUNCT B-O -( PUNCT B-O -f X B-O -) PUNCT B-O -recurrent ADJ B-O -use NOUN B-O -of ADP B-O -postexposure ADJ B-O -prophylaxis NOUN B-O -; PUNCT B-O -( PUNCT B-O -g X B-O -) PUNCT B-O -recurrent ADJ B-O -sex NOUN B-O -under ADP B-O -the DET B-O -influence NOUN B-O -of ADP B-O -alcohol NOUN B-O -and/or CCONJ B-O -recreational ADJ B-O -drugs NOUN B-O -; PUNCT B-O -( PUNCT B-O -h X B-O -) PUNCT B-O -injection NOUN B-O -drug NOUN B-O -use NOUN B-O -with ADP B-O -shared VERB B-O -needles NOUN B-O -and/or CCONJ B-O -syringes NOUN B-O -; PUNCT B-O -and CCONJ B-O -( PUNCT B-O -i X B-O -) PUNCT B-O -having VERB B-O -an DET B-O -HIV PROPN B-O -- PUNCT B-O -positive ADJ B-O -partner NOUN B-O -[ PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -One NUM B-O -recent ADJ B-O -study NOUN B-O -found VERB B-O -that SCONJ B-O -healthy ADJ B-O -lifestyle NOUN B-O -profiles NOUN B-O -were AUX B-O -associated VERB B-O -with ADP B-O -lower ADJ B-O -risks NOUN B-O -of ADP B-O -dementia NOUN B-O -only ADV B-O -among ADP B-O -apolipoprotein NOUN B-LF -E PROPN I-LF -( PUNCT B-O -APOE PROPN B-AC -) PUNCT B-O -ε4 NUM B-O -noncarriers NOUN B-O -, PUNCT B-O -but CCONJ B-O -not PART B-O -among ADP B-O -carriers NOUN B-O -. PUNCT B-O - -HIV PROPN B-AC -/ SYM B-O -AIDS PROPN B-AC -predisposes VERB B-O -for ADP B-O -Mycobacterium NOUN B-O -tuberculosis NOUN B-LF -( PUNCT B-O -MTB NOUN B-O -) PUNCT B-O -infection NOUN B-O -and CCONJ B-O -increases VERB B-O -the DET B-O -rate NOUN B-O -of ADP B-O -recurrent ADJ B-O -TB PROPN B-AC -as ADP B-O -well ADV B-O -as ADP B-O -of ADP B-O -rapid ADJ B-O -progress NOUN B-O -to ADP B-O -active ADJ B-O -TB PROPN B-AC -among ADP B-O -individuals NOUN B-O -with ADP B-O -recently ADV B-O -acquired VERB B-O -infection NOUN B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -These DET B-O -properties NOUN B-O -of ADP B-O -the DET B-O -IVs PROPN B-AC -are AUX B-O -discussed VERB B-O -in ADP B-O -more ADJ B-O -detail NOUN B-O -in ADP B-O -the DET B-O -section NOUN B-O -, PUNCT B-O -Assumptions NOUN B-O -and CCONJ B-O -Limitations NOUN B-O -of ADP B-O -Instrumental ADJ B-LF -Variables NOUN I-LF -in ADP B-O -Text PROPN B-O -S1 NUM B-O -. PUNCT B-O - -CDS PROPN B-AC -, PUNCT B-O -coding NOUN B-LF -sequence NOUN I-LF -; PUNCT B-O -TE PROPN B-AC -, PUNCT B-O -transposable ADJ B-LF -element NOUN I-LF -. PUNCT B-O - -On ADP B-O -exposure NOUN B-O -to ADP B-O -stress NOUN B-O -condition NOUN B-O -these DET B-O -defence NOUN B-O -systems NOUN B-O -are AUX B-O -activated VERB B-O -both CCONJ B-O -enzymatically ADV B-O -( PUNCT B-O -ascorbate NOUN B-O -peroxidase NOUN B-O -, PUNCT B-O -catalase NOUN B-O -, PUNCT B-O -superoxide NOUN B-O -dismutase NOUN B-O -and CCONJ B-O -peroxidase NOUN B-O -) PUNCT B-O -and CCONJ B-O -non ADV B-O -- ADV B-O -enzymatically ADV B-O -( PUNCT B-O -secondary ADJ B-O -metabolites NOUN B-O -) PUNCT B-O -scavenging VERB B-O -the DET B-O -reactive ADJ B-LF -oxygen NOUN I-LF -species NOUN I-LF -( PUNCT B-O -ROS PROPN B-AC -) PUNCT B-O -formed VERB B-O -as ADP B-O -result NOUN B-O -of ADP B-O -stress NOUN B-O -condition NOUN B-O -[ PUNCT B-O -76 NUM B-O -] PUNCT B-O -. PUNCT B-O - -EV PROPN B-AC -, PUNCT B-O -extracellular ADJ B-LF -vesicle NOUN I-LF -; PUNCT B-O -LPS PROPN B-AC -, PUNCT B-O -lipopolysaccharide NOUN B-LF -. PUNCT B-O - -Pseudohyphal ADJ B-O -growth NOUN B-O -requires VERB B-O -the DET B-O -initiation NOUN B-O -of ADP B-O -polarised ADJ B-O -growth NOUN B-O -for ADP B-O -cellular ADJ B-O -elongation NOUN B-O -and CCONJ B-O -is AUX B-O -under ADP B-O -the DET B-O -control NOUN B-O -of ADP B-O -two NUM B-O -signaling NOUN B-O -pathways NOUN B-O -: PUNCT B-O -a DET B-O -cyclic ADJ B-LF -adenosine NOUN I-LF -monophosphate NOUN I-LF -( PUNCT B-O -kinase NOUN I-LF -cAMP)/protein PROPN B-AC -A NOUN I-LF -( PUNCT B-O -PKA PROPN B-AC -) PUNCT B-O -pathway NOUN B-O -and CCONJ B-O -a DET B-O -mitogen NOUN B-LF -- PUNCT I-LF -activated VERB I-LF -protein NOUN I-LF -kinase NOUN I-LF -( PUNCT B-O -MAPK PROPN B-AC -) PUNCT B-O -cascade NOUN B-O -. PUNCT B-O - -Half NOUN B-O -of ADP B-O -the DET B-O -digest NOUN B-O -( PUNCT B-O -500 NUM B-O -µl NOUN B-O -) PUNCT B-O -was AUX B-O -loaded VERB B-O -on ADP B-O -a DET B-O -strong ADJ B-LF -anion NOUN I-LF -exchange NOUN I-LF -( PUNCT B-O -SAX PROPN B-AC -) PUNCT B-O -column NOUN B-O -( PUNCT B-O -SAX PROPN B-AC -- PUNCT B-O -Zirchrom PROPN B-O -2.1 NUM B-O -mm NOUN B-O -I.D.×150 NOUN B-O -mm NOUN B-O -length NOUN B-O -; PUNCT B-O -3 NUM B-O -µm NOUN B-O -particles NOUN B-O -, PUNCT B-O -ZirChrom PROPN B-O -Separations PROPN B-O -, PUNCT B-O -Anoka PROPN B-O -, PUNCT B-O -MN PROPN B-O -, PUNCT B-O -USA PROPN B-O -) PUNCT B-O -after ADP B-O -which PRON B-O -a DET B-O -binary ADJ B-O -solvent NOUN B-O -gradient NOUN B-O -was AUX B-O -applied VERB B-O -to ADP B-O -fractionate NOUN B-O -peptides NOUN B-O -. PUNCT B-O - -The DET B-O -host NOUN B-O -- PUNCT B-O -encoded VERB B-O -glycophosphatidylinositol NOUN B-O -anchored VERB B-O -prion NOUN B-O -protein NOUN B-O -, PUNCT B-O -PrPC PROPN B-O -, PUNCT B-O -is AUX B-O -essential ADJ B-O -for ADP B-O -the DET B-O -development NOUN B-O -of ADP B-O -TSE PROPN B-AC -disease NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -a DET B-O -common ADJ B-O -feature NOUN B-O -of ADP B-O -these DET B-O -diseases NOUN B-O -is AUX B-O -the DET B-O -accumulation NOUN B-O -of ADP B-O -PrPSc PROPN B-O -in ADP B-O -the DET B-O -brain NOUN B-O -, PUNCT B-O -an DET B-O -abnormal ADJ B-O -form NOUN B-O -of ADP B-O -PrPC PROPN B-O -, PUNCT B-O -which PRON B-O -displays VERB B-O -partial ADJ B-O -resistance NOUN B-O -to ADP B-O -proteinase NOUN B-LF -K PROPN I-LF -( PUNCT B-O -PK PROPN B-AC -) PUNCT B-O -digestion NOUN B-O -. PUNCT B-O - -Lung NOUN B-O -adenocarcinomas NOUN B-O -from ADP B-O -patients NOUN B-O -who PRON B-O -respond VERB B-O -to ADP B-O -the DET B-O -tyrosine NOUN B-O -kinase NOUN B-O -inhibitors NOUN B-O -gefitinib PROPN B-O -( PUNCT B-O -Iressa PROPN B-O -) PUNCT B-O -or CCONJ B-O -erlotinib PROPN B-O -( PUNCT B-O -Tarceva PROPN B-O -) PUNCT B-O -usually ADV B-O -harbor VERB B-O -somatic ADJ B-O -gain NOUN B-O -- PUNCT B-O -of ADP B-O -- PUNCT B-O -function NOUN B-O -mutations NOUN B-O -in ADP B-O -exons NOUN B-O -encoding VERB B-O -the DET B-O -kinase NOUN B-O -domain NOUN B-O -of ADP B-O -the DET B-O -epidermal ADJ B-LF -growth NOUN I-LF -factor NOUN I-LF -receptor NOUN I-LF -( PUNCT B-O -EGFR PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Despite SCONJ B-O -initial ADJ B-O -responses NOUN B-O -, PUNCT B-O -patients NOUN B-O -eventually ADV B-O -progress VERB B-O -by ADP B-O -unknown ADJ B-O -mechanisms NOUN B-O -of ADP B-O -“ PUNCT B-O -acquired VERB B-O -” PUNCT B-O -resistance NOUN B-O -. PUNCT B-O - -A DET B-O -total NOUN B-O -of ADP B-O -1,045 NUM B-O -genes NOUN B-O -( PUNCT B-O -551 NUM B-O -up ADV B-O -- PUNCT B-O -regulated VERB B-O -and CCONJ B-O -494 NUM B-O -down ADV B-O -- PUNCT B-O -regulated VERB B-O -) PUNCT B-O -were AUX B-O -DE PROPN B-AC -in ADP B-O -the DET B-O -FPC PROPN B-AC -/ SYM B-O -CC PROPN B-AC -( PUNCT B-O -region NOUN B-O -1 NUM B-O -, PUNCT B-O -S1 NUM B-O -Table PROPN B-O -) PUNCT B-O -, PUNCT B-O -644 NUM B-O -genes NOUN B-O -( PUNCT B-O -492 NUM B-O -up ADV B-O -- PUNCT B-O -regulated VERB B-O -and CCONJ B-O -152 NUM B-O -down ADV B-O -- PUNCT B-O -regulated VERB B-O -) PUNCT B-O -in ADP B-O -the DET B-O -HP PROPN B-AC -( PUNCT B-O -region NOUN B-O -2 NUM B-O -, PUNCT B-O -S2 NUM B-O -Table PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -1,137 NUM B-O -( PUNCT B-O -526 NUM B-O -up ADV B-O -- PUNCT B-O -regulated VERB B-O -and CCONJ B-O -611 NUM B-O -downregulated ADJ B-O -) PUNCT B-O -in ADP B-O -the DET B-O -RB PROPN B-AC -( PUNCT B-O -region NOUN B-O -3 NUM B-O -, PUNCT B-O -S3 PROPN B-O -Table PROPN B-O -) PUNCT B-O -( PUNCT B-O -Fig NOUN B-O -1A NUM B-O -) PUNCT B-O -. PUNCT B-O - -Gene NOUN B-O -set NOUN B-O -enrichment NOUN B-O -analysis NOUN B-O -( PUNCT B-O -using VERB B-O -DAVID PROPN B-O -, PUNCT B-O -see VERB B-O -Methods NOUN B-O -) PUNCT B-O -showed VERB B-O -significant ADJ B-O -differences NOUN B-O -between ADP B-O -the DET B-O -regions NOUN B-O -, PUNCT B-O -i.e. X B-O -, PUNCT B-O -DE PROPN B-AC -genes NOUN B-O -from ADP B-O -each PRON B-O -of ADP B-O -the DET B-O -three NUM B-O -regions NOUN B-O -were AUX B-O -present ADJ B-O -in ADP B-O -overlapping VERB B-O -but CCONJ B-O -not PART B-O -identical ADJ B-O -Kyoto PROPN B-LF -Encyclopedia PROPN I-LF -of ADP I-LF -genes NOUN I-LF -and CCONJ I-LF -genomes NOUN I-LF -( PUNCT B-O -KEGG PROPN B-AC -) PUNCT B-O -pathways NOUN B-O -( PUNCT B-O -S4 PROPN B-O -Table PROPN B-O -) PUNCT B-O -. PUNCT B-O - -NSE PROPN B-AC -, PUNCT B-O -neuron NOUN B-LF -specific ADJ I-LF -enolase NOUN I-LF -. PUNCT B-O - -In ADP B-O -a DET B-O -next ADJ B-O -step NOUN B-O -we PRON B-O -further ADV B-O -quantified VERB B-O -the DET B-O -voltage NOUN B-O -firing NOUN B-O -threshold NOUN B-O -( PUNCT B-O --28 NUM B-O -– PUNCT B-O --49 NUM B-O -mV NOUN B-O -) PUNCT B-O -, PUNCT B-O -the DET B-O -maximum ADJ B-O -firing NOUN B-O -frequency NOUN B-O -( PUNCT B-O -10–202 NUM B-O -Hz NOUN B-O -) PUNCT B-O -in ADP B-O -response NOUN B-O -to ADP B-O -a DET B-O -100 NUM B-O -pA NOUN B-O -step NOUN B-O -, PUNCT B-O -the DET B-O -amplitude NOUN B-O -of ADP B-O -both CCONJ B-O -spontaneous ADJ B-O -( PUNCT B-O -18–80 NUM B-O -mV NOUN B-O -) PUNCT B-O -and CCONJ B-O -evoked VERB B-O -action NOUN B-O -potentials NOUN B-O -( PUNCT B-O -17–76 NUM B-O -mV NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -amplitude NOUN B-O -( PUNCT B-O -0–18 NUM B-O -mV NOUN B-O -) PUNCT B-O -and CCONJ B-O -time NOUN B-O -point NOUN B-O -of ADP B-O -the DET B-O -fast ADJ B-LF -after ADP I-LF -- PUNCT I-LF -hyperpolarization NOUN I-LF -peak NOUN I-LF -( PUNCT B-O -fAHP PROPN B-AC -) PUNCT B-O -following VERB B-O -a DET B-O -spike NOUN B-O -( PUNCT B-O -0,2–3,8 NUM B-O -ms NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Fluorescence NOUN B-LF -correlation NOUN I-LF -spectroscopy NOUN I-LF -( PUNCT B-O -FCS PROPN B-AC -) PUNCT B-O -measurements NOUN B-O -were AUX B-O -carried VERB B-O -out ADP B-O -with ADP B-O -a DET B-O -home NOUN B-O -- PUNCT B-O -made VERB B-O -FCS PROPN B-AC -setup NOUN B-O -[ X B-O -56,57 X B-O -] X B-O -including VERB B-O -an DET B-O -Olympus PROPN B-O -IMT-2 PROPN B-O -inverted ADJ B-O -microscope NOUN B-O -with ADP B-O -a DET B-O -40x NUM B-O -, PUNCT B-O -NA NOUN B-O -1.2 NUM B-O -water NOUN B-O -immersion NOUN B-O -objective NOUN B-O -( PUNCT B-O -Carl PROPN B-O -Zeiss PROPN B-O -, PUNCT B-O -Jena PROPN B-O -, PUNCT B-O -Germany PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Given VERB B-O -clinicians NOUN B-O -’ PUNCT B-O -frequent ADJ B-O -concerns NOUN B-O -about ADP B-O -unfavourable ADJ B-O -outcomes NOUN B-O -, PUNCT B-O -Intensive PROPN B-LF -Care PROPN I-LF -Unit PROPN I-LF -( PUNCT B-O -ICU PROPN B-AC -) PUNCT B-O -triage NOUN B-O -decisions NOUN B-O -in ADP B-O -acutely ADV B-O -ill ADJ B-O -cancer NOUN B-O -patients NOUN B-O -can AUX B-O -be AUX B-O -difficult ADJ B-O -, PUNCT B-O -as SCONJ B-O -clinicians NOUN B-O -may AUX B-O -have VERB B-O -doubts NOUN B-O -about ADP B-O -the DET B-O -appropriateness NOUN B-O -of ADP B-O -an DET B-O -ICU PROPN B-AC -admission NOUN B-O -. PUNCT B-O - -While SCONJ B-O -Categories NOUN B-O -I NUM B-O -and CCONJ B-O -II NUM B-O -are AUX B-O -integrated VERB B-O -in ADP B-O -the DET B-O -swing NOUN B-O -equation NOUN B-O -, PUNCT B-O -the DET B-O -admittance NOUN B-LF -matrix NOUN I-LF -Y PROPN B-AC -is AUX B-O -modified VERB B-O -to PART B-O -incorporate VERB B-O -Categories NOUN B-O -III NUM B-O -and CCONJ B-O -IV NUM B-O -in ADP B-O -terms NOUN B-O -of ADP B-O -the DET B-O -voltage NOUN B-O -– PUNCT B-O -current NOUN B-O -relationship NOUN B-O -. PUNCT B-O - -Further ADJ B-O -cryogenic ADJ B-LF -electron NOUN I-LF -microscopy NOUN I-LF -( PUNCT B-O -cryo-EM PROPN B-AC -) PUNCT B-O -maps NOUN B-O -of ADP B-O -the DET B-O -CsgG PROPN B-O -- PUNCT B-O -CsgE PROPN B-O -complex NOUN B-O -indicate VERB B-O -that SCONJ B-O -CsgE PROPN B-O -could AUX B-O -oligomerize VERB B-O -to PART B-O -form VERB B-O -nonamers NOUN B-O -in ADP B-O -the DET B-O -periplasm NOUN B-O -, PUNCT B-O -“ PUNCT B-O -capping VERB B-O -” PUNCT B-O -the DET B-O -periplasmic ADJ B-O -side NOUN B-O -of ADP B-O -the DET B-O -CsgG PROPN B-O -channel NOUN B-O -[ PUNCT B-O -26,27 NUM B-O -] PUNCT B-O -. PUNCT B-O - -To PART B-O -produce VERB B-O -LEGO PROPN B-AC -libraries NOUN B-O -, PUNCT B-O -we PRON B-O -designed VERB B-O -a DET B-O -set NOUN B-O -of ADP B-O -oligonucleotide NOUN B-O -adapters NOUN B-O -A NOUN B-O -, PUNCT B-O -B NOUN B-O -, PUNCT B-O -and CCONJ B-O -C NOUN B-O -( PUNCT B-O -Figures NOUN B-O -A NOUN B-O -, PUNCT B-O -B NOUN B-O -in ADP B-O -S1 NUM B-O -Fig NOUN B-O -) PUNCT B-O -that PRON B-O -allow VERB B-O -( PUNCT B-O -1 X B-O -) PUNCT B-O -highly ADV B-O -optimized VERB B-O -PCR NOUN B-O -- PUNCT B-O -based VERB B-O -Suppression PROPN B-LF -Subtractive PROPN I-LF -Hybridization PROPN I-LF -( PUNCT B-O -SSH PROPN B-AC -) PUNCT B-O -of ADP B-O -two NUM B-O -transcriptomes NOUN B-O -[ X B-O -7 X B-O -] X B-O -to PART B-O -selectively ADV B-O -amplify VERB B-O -cDNA NOUN B-O -sequences NOUN B-O -from ADP B-O -repressed VERB B-O -polyadenylated VERB B-O -transcripts NOUN B-O -( PUNCT B-O -see VERB B-O -for ADP B-O -schematic ADJ B-O -design NOUN B-O -Figures NOUN B-O -C NOUN B-O -, PUNCT B-O -D NOUN B-O -in ADP B-O -S1 NUM B-O -Fig NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -( PUNCT B-O -2 X B-O -) PUNCT B-O -subsequent ADJ B-O -enzymatic ADJ B-O -processing NOUN B-O -of ADP B-O -selected VERB B-O -cDNA NOUN B-O -sequences NOUN B-O -into ADP B-O -a DET B-O -library NOUN B-O -of ADP B-O -pRETRO PROPN B-O -Super PROPN B-O -shRNA NOUN B-O -vectors NOUN B-O -for ADP B-O -screening NOUN B-O -( PUNCT B-O -Figure PROPN B-O -I NUM B-O -in ADP B-O -S1 NUM B-O -Fig NOUN B-O -) PUNCT B-O -. PUNCT B-O - -* PUNCT B-O -As ADP B-O -compared VERB B-O -with ADP B-O -female NOUN B-O -; PUNCT B-O -Ref NOUN B-O -: PUNCT B-O -reference NOUN B-O -category NOUN B-O -; PUNCT B-O -reduced VERB B-O -staff NOUN B-O -: PUNCT B-O -weekend NOUN B-O -and CCONJ B-O -public ADJ B-O -holydays NOUN B-O -admissions NOUN B-O -; PUNCT B-O -RRT PROPN B-AC -: PUNCT B-O -renal ADJ B-LF -replacement NOUN I-LF -therapy NOUN I-LF -; PUNCT B-O -“ PUNCT B-O -SAMU PROPN B-O -” PUNCT B-O -: PUNCT B-O -Service PROPN B-O -d’Aide PROPN B-O -Médicale PROPN B-O -Urgente PROPN B-O -: PUNCT B-O -mobile ADJ B-O -emergency NOUN B-O -team NOUN B-O -. PUNCT B-O - -CTRL PROPN B-O -, PUNCT B-O -control NOUN B-O -group NOUN B-O -; PUNCT B-O -ECD PROPN B-AC -, PUNCT B-O -early ADJ B-LF -child NOUN I-LF -development NOUN I-LF -; PUNCT B-O -EI PROPN B-O -, PUNCT B-O -Educación PROPN B-O -Inicial PROPN B-O -; PUNCT B-O -ICDS PROPN B-O -, PUNCT B-O -Integrated PROPN B-O -Child PROPN B-O -Development PROPN B-O -Services PROPN B-O -; PUNCT B-O -INT PROPN B-O -, PUNCT B-O -intervention NOUN B-O -group NOUN B-O -; PUNCT B-O -RCT PROPN B-O -, PUNCT B-O -randomized VERB B-O -controlled ADJ B-O -trial NOUN B-O -; PUNCT B-O -RFS PROPN B-O -, PUNCT B-O -Responsive PROPN B-O -Feeding PROPN B-O -and CCONJ B-O -Stimulation PROPN B-O -; PUNCT B-O -VIP PROPN B-O -, PUNCT B-O -Video PROPN B-O -Interaction PROPN B-O -Project PROPN B-O -; PUNCT B-O -VIPP PROPN B-O -, PUNCT B-O -video NOUN B-O -- PUNCT B-O -feedback NOUN B-O -intervention NOUN B-O -to PART B-O -promote VERB B-O -positive ADJ B-O -parenting NOUN B-O -; PUNCT B-O -Of ADP B-O -the DET B-O -49,717 NUM B-O -individuals NOUN B-O -enrolled VERB B-O -in ADP B-O -the DET B-O -D:A:D PROPN B-AC -study NOUN B-O -, PUNCT B-O -27,215 NUM B-O -( PUNCT B-O -55 NUM B-O -% PUNCT B-O -) PUNCT B-O -had VERB B-O -the DET B-O -required VERB B-O -complete ADJ B-O -covariate NOUN B-O -data NOUN B-O -after ADP B-O -1 NUM B-O -January PROPN B-O -2004 NUM B-O -and CCONJ B-O -were AUX B-O -included VERB B-O -in ADP B-O -this DET B-O -analysis NOUN B-O -, PUNCT B-O -contributing VERB B-O -202,034 NUM B-O -person NOUN B-LF -- PUNCT I-LF -years NOUN I-LF -( PUNCT B-O -pyrs PROPN B-AC -) PUNCT B-O -of ADP B-O -follow NOUN B-O -- PUNCT B-O -up NOUN B-O -. PUNCT B-O - -We PRON B-O -calculated VERB B-O -the DET B-O -sensitivity NOUN B-O -, PUNCT B-O -specificity NOUN B-O -and CCONJ B-O -accuracy NOUN B-O -of ADP B-O -our PRON B-O -algorithm NOUN B-O -to PART B-O -detect VERB B-O -VVA PROPN B-AC -after ADP B-O -finding VERB B-O -an DET B-O -optimal ADJ B-O -DCVV PROPN B-AC -cut NOUN B-O -- PUNCT B-O -off NOUN B-O -using VERB B-O -Receiver PROPN B-LF -Operating PROPN I-LF -Characteristics NOUN I-LF -( PUNCT B-O -ROC PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Youden PROPN B-O -- PUNCT B-O -Index PROPN B-O -( PUNCT B-O -J NOUN B-O -) PUNCT B-O -. PUNCT B-O - -A DET B-O -ROC PROPN B-AC -curve NOUN B-O -was AUX B-O -generated VERB B-O -using VERB B-O -SPSS PROPN B-O -. PUNCT B-O - -For ADP B-O -all DET B-O -statistical ADJ B-O -analyses NOUN B-O -, PUNCT B-O -the DET B-O -level NOUN B-O -of ADP B-O -significance NOUN B-O -was AUX B-O -set VERB B-O -at ADP B-O -p NOUN B-O -< ADP B-O -0.05 NUM B-O -( PUNCT B-O -two NUM B-O -- PUNCT B-O -tailed VERB B-O -) PUNCT B-O -. PUNCT B-O - -Deletion NOUN B-O -of ADP B-O -kinases NOUN B-O -regulated VERB B-O -by ADP B-O -Ras PROPN B-O -such ADJ B-O -as ADP B-O -extracellular ADJ B-LF -signal NOUN I-LF -regulated VERB I-LF -kinase NOUN I-LF -( PUNCT B-O -ERK PROPN B-AC -) PUNCT B-O -, PUNCT B-O -glycogen NOUN B-O -synthase NOUN B-O -kinase NOUN B-O -( PUNCT B-O -GSK-3 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -mammalian ADJ B-LF -target NOUN I-LF -of ADP I-LF -rapamycin NOUN I-LF -( PUNCT B-O -mTOR PROPN B-AC -) PUNCT B-O -in ADP B-O -discrete ADJ B-O -populations NOUN B-O -of ADP B-O -MSNs PROPN B-AC -also ADV B-O -affects VERB B-O -motor NOUN B-O -activity NOUN B-O -and/or CCONJ B-O -responses NOUN B-O -to ADP B-O -psychostimulants NOUN B-O -[ PUNCT B-O -28–30 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -similar ADJ B-O -effects NOUN B-O -are AUX B-O -observed VERB B-O -upon SCONJ B-O -changes NOUN B-O -in ADP B-O -Ras PROPN B-O -activity NOUN B-O -[ PUNCT B-O -31,32 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -some DET B-O -organisms NOUN B-O -, PUNCT B-O -additional ADJ B-O -γ PUNCT B-LF -- PUNCT I-LF -tubulin NOUN I-LF -complex NOUN I-LF -proteins NOUN I-LF -( PUNCT B-O -GCPs PROPN B-AC -) PUNCT B-O -combine VERB B-O -with ADP B-O -the DET B-O -γ PROPN B-AC -to PART B-O -form VERB B-O -the DET B-O -larger ADJ B-O -γ PUNCT B-LF -- PUNCT I-LF -tubulin NOUN I-LF -ring NOUN I-LF -complex NOUN I-LF -( PUNCT B-O --TuSCγ PROPN B-AC -) PUNCT B-O -; PUNCT B-O -organisms NOUN B-O -lacking VERB B-O -these DET B-O -additional ADJ B-O --TuRCGCPs PROPN B-AC -are AUX B-O -thought VERB B-O -to PART B-O -oligomerize VERB B-O -γ PROPN B-AC -into ADP B-O -similar ADJ B-O -ring NOUN B-O -complexes NOUN B-O -[ PUNCT B-O -12,13 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -data NOUN B-O -was AUX B-O -normalized VERB B-O -to ADP B-O -the DET B-O -H/L PROPN B-AC -( PUNCT B-O -Heavy ADJ B-LF -/ SYM I-LF -Light NOUN I-LF -) PUNCT B-O -ratio NOUN B-O -of ADP B-O -the DET B-O -Pwp2p NOUN B-O -bait NOUN B-O -to ADP B-O -correct VERB B-O -for ADP B-O -the DET B-O -reduced VERB B-O -purification NOUN B-O -( PUNCT B-O -the DET B-O -H PROPN B-AC -ratio NOUN B-O -of ADP B-O -Pwp2p NOUN B-O -was AUX B-O -set VERB B-O -to ADP B-O -1 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Weight NOUN B-O -and CCONJ B-O -height NOUN B-O -were AUX B-O -measured VERB B-O -by ADP B-O -trained VERB B-O -professionals NOUN B-O -to ADP B-O -standardised ADJ B-O -protocols NOUN B-O -, PUNCT B-O -and CCONJ B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -was AUX B-O -calculated VERB B-O -as ADP B-O -weight NOUN B-O -divided VERB B-O -by ADP B-O -squared VERB B-O -height NOUN B-O -( PUNCT B-O -kg NOUN B-O -/ SYM B-O -m2 NOUN B-O -) PUNCT B-O -. PUNCT B-O - -95 NUM B-O -% NOUN B-O -CI NOUN B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-O -interval NOUN B-O -; PUNCT B-O -HR PROPN B-AC -, PUNCT B-O -hazard NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -PSA PROPN B-AC -, PUNCT B-O -prostate NOUN B-LF -- PUNCT I-LF -specific ADJ I-LF -antigen NOUN I-LF -; PUNCT B-O -pT NOUN B-O -, PUNCT B-O -pathological ADJ B-O -staging NOUN B-O -of ADP B-O -the DET B-O -primary ADJ B-O -tumor NOUN B-O -; PUNCT B-O -RP PROPN B-AC -, PUNCT B-O -radical ADJ B-LF -prostatectomy NOUN I-LF -. PUNCT B-O - -Recent ADJ B-O -studies NOUN B-O -suggest VERB B-O -that SCONJ B-O -necroptosis NOUN B-O -is AUX B-O -mediated VERB B-O -by ADP B-O -receptor NOUN B-LF -interacting VERB I-LF -protein NOUN I-LF -3 NUM I-LF -( PUNCT B-O -RIP3)[7 PROPN B-AC -, PUNCT B-O -8 NUM B-O -] PUNCT B-O -. PUNCT B-O - -SNP PROPN B-AC -: PUNCT B-O -single ADJ B-LF -nucleotide NOUN I-LF -polymorphism NOUN I-LF -; PUNCT B-O -CTEPH PROPN B-AC -: PUNCT B-O -chronic ADJ B-LF -thromboembolic ADJ I-LF -pulmonary ADJ I-LF -hypertension NOUN I-LF -; PUNCT B-O -PE PROPN B-AC -: PUNCT B-O -pulmonary ADJ B-O -embolism NOUN B-O -; PUNCT B-O -PAH PROPN B-AC -: PUNCT B-O -pulmonary ADJ B-LF -arterial ADJ I-LF -hypertension NOUN I-LF -. PUNCT B-O - -We PRON B-O -simulated VERB B-O -populations NOUN B-O -using VERB B-O -an DET B-O -agent NOUN B-LF -- PUNCT I-LF -based VERB I-LF -model NOUN I-LF -( PUNCT B-O -ABM PROPN B-AC -) PUNCT B-O -and CCONJ B-O -sampled VERB B-O -them PRON B-O -monthly ADV B-O -for ADP B-O -25 NUM B-O -years NOUN B-O -with ADP B-O -a DET B-O -total NOUN B-O -of ADP B-O -300 NUM B-O -time NOUN B-O -points NOUN B-O -, PUNCT B-O -where SCONJ B-O -each DET B-O -time NOUN B-O -point NOUN B-O -is AUX B-O -a DET B-O -snapshot NOUN B-O -of ADP B-O -changes NOUN B-O -accumulated VERB B-O -in ADP B-O -the DET B-O -parasite NOUN B-O -population NOUN B-O -during ADP B-O -a DET B-O -30 NUM B-O -- PUNCT B-O -day NOUN B-O -period NOUN B-O -. PUNCT B-O - -An DET B-O -analysis NOUN B-O -of ADP B-O -the DET B-O -putative ADJ B-O -cis ADJ B-O -- ADJ B-O -regulatory ADJ B-O -elements NOUN B-O -that SCONJ B-O -were AUX B-O -present ADJ B-O -in ADP B-O -the DET B-O -promoter NOUN B-O -sequences NOUN B-O -of ADP B-O -aquaporin NOUN B-O -genes NOUN B-O -belonging VERB B-O -to ADP B-O -TIP PROPN B-AC -subfamily NOUN B-O -led VERB B-O -to ADP B-O -the DET B-O -conclusion NOUN B-O -that SCONJ B-O -their PRON B-O -expression NOUN B-O -may AUX B-O -be AUX B-O -regulated VERB B-O -in ADP B-O -response NOUN B-O -to ADP B-O -hormones NOUN B-O -such ADJ B-O -as SCONJ B-O -abscisic NOUN B-LF -acid NOUN I-LF -( PUNCT B-O -ABA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -methyl NOUN B-LF -jasmonate NOUN I-LF -( PUNCT B-O -MeJA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -auxin NOUN B-O -and CCONJ B-O -gibberellin NOUN B-O -( PUNCT B-O -GA PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -presence NOUN B-O -of ADP B-O -ABRE PROPN B-O -in ADP B-O -the DET B-O -investigated VERB B-O -promoters NOUN B-O -suggests VERB B-O -a DET B-O -possible ADJ B-O -role NOUN B-O -of ADP B-O -ABA PROPN B-AC -in ADP B-O -the DET B-O -control NOUN B-O -of ADP B-O -HvTIP PROPN B-O -expression NOUN B-O -as SCONJ B-O -has AUX B-O -already ADV B-O -been AUX B-O -reported VERB B-O -for ADP B-O -some DET B-O -TIP PROPN B-AC -genes NOUN B-O -in ADP B-O -barley NOUN B-O -. PUNCT B-O - -CS PROPN B-AC -, PUNCT B-O -cesarean ADJ B-LF -section NOUN I-LF -; PUNCT B-O -HELLP PROPN B-AC -, PUNCT B-O -hemolysis NOUN B-O -, PUNCT B-O -elevated ADJ B-O -liver NOUN B-O -enzymes NOUN B-O -, PUNCT B-O -low ADJ B-O -platelet NOUN B-O -count NOUN B-O -. PUNCT B-O - -We PRON B-O -assessed VERB B-O -the DET B-O -efficiency NOUN B-O -of ADP B-O -gene NOUN B-O -discovery NOUN B-O -by ADP B-O -calculating VERB B-O -the DET B-O -percentage NOUN B-O -of ADP B-O -known VERB B-O -genes NOUN B-O -tagged VERB B-O -as ADP B-O -a DET B-O -function NOUN B-O -of ADP B-O -read VERB B-O -number NOUN B-O -for ADP B-O -MF PROPN B-AC -and CCONJ B-O -compared VERB B-O -this DET B-O -value NOUN B-O -to ADP B-O -the DET B-O -rate NOUN B-O -of ADP B-O -gene NOUN B-O -discovery NOUN B-O -obtained VERB B-O -by ADP B-O -expressed VERB B-LF -sequence NOUN I-LF -tags NOUN I-LF -( PUNCT B-O -ESTs PROPN B-AC -) PUNCT B-O -for ADP B-O -sorghum NOUN B-O -( PUNCT B-O -Figure PROPN B-O -2 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Alternative ADJ B-O -, PUNCT B-O -community NOUN B-O -- PUNCT B-O -based VERB B-O -approaches NOUN B-O -are AUX B-O -required VERB B-O -to PART B-O -meet VERB B-O -the DET B-O -Joint PROPN B-LF -United PROPN I-LF -Nations PROPN I-LF -Programme PROPN I-LF -on ADP I-LF -HIV PROPN I-LF -/ SYM I-LF -AIDS PROPN I-LF -( PUNCT B-O -UNAIDS PROPN B-AC -) PUNCT B-O -target NOUN B-O -of ADP B-O -diagnosing VERB B-O -90 NUM B-O -% NOUN B-O -of ADP B-O -those PRON B-O -living VERB B-O -with ADP B-O -HIV PROPN B-O -by ADP B-O -2020 NUM B-O -in ADP B-O -this DET B-O -age NOUN B-O -group NOUN B-O -. PUNCT B-O - -Baht PROPN B-O -can AUX B-O -be AUX B-O -converted VERB B-O -to ADP B-O -$ SYM B-O -US PROPN B-O -by ADP B-O -dividing VERB B-O -by ADP B-O -31.16 NUM B-O -; PUNCT B-O -T1MI PROPN B-AC -, PUNCT B-O -type NOUN B-O -1 NUM B-O -myocardial ADJ B-LF -infarction NOUN I-LF -; PUNCT B-O -ASCVD PROPN B-AC -, PUNCT B-O -atherosclerotic ADJ B-LF -cardiovascular ADJ I-LF -disease NOUN I-LF -; PUNCT B-O -QALY PROPN B-AC -, PUNCT B-O -quality NOUN B-LF -- PUNCT I-LF -adjusted VERB I-LF -life NOUN I-LF -- PUNCT I-LF -year NOUN I-LF -; PUNCT B-O -ICER PROPN B-AC -, PUNCT B-O -incremental ADJ B-LF -cost NOUN I-LF -- PUNCT I-LF -effectiveness NOUN I-LF -ratio NOUN I-LF -; PUNCT B-O -Rama PROPN B-AC -, PUNCT B-O -Ramathibodi PROPN B-LF -- PUNCT I-LF -Electricity PROPN I-LF -Generating PROPN I-LF -Authority PROPN I-LF -of ADP I-LF -Thailand PROPN I-LF -. PUNCT B-O - -Since SCONJ B-O -histone NOUN B-O -acetylation NOUN B-O -is AUX B-O -controlled VERB B-O -by ADP B-O -the DET B-O -balance NOUN B-O -of ADP B-O -histone NOUN B-LF -acetyltransferases NOUN I-LF -( PUNCT B-O -HATs PROPN B-AC -) PUNCT B-O -and CCONJ B-O -deacetylases NOUN B-O -( PUNCT B-O -HDACs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -we PRON B-O -next ADV B-O -asked VERB B-O -whether SCONJ B-O -blocking VERB B-O -HDAC PROPN B-AC -function NOUN B-O -would AUX B-O -reactivate VERB B-O -IFN PROPN B-AC -- PUNCT B-O -λ PUNCT B-O -receptor NOUN B-O -expression NOUN B-O -in ADP B-O -nonresponsive ADJ B-O -cells NOUN B-O -. PUNCT B-O - -In ADP B-O -the DET B-O -present ADJ B-O -study NOUN B-O -, PUNCT B-O -we PRON B-O -investigated VERB B-O -the DET B-O -effect NOUN B-O -of ADP B-O -a DET B-O -sub ADJ B-O -- PUNCT B-O -chronic ADJ B-O -treatment NOUN B-O -with ADP B-O -local ADJ B-LF -cryotherapy NOUN I-LF -( PUNCT B-O -LC PROPN B-AC -) PUNCT B-O -in ADP B-O -the DET B-O -widely ADV B-O -- PUNCT B-O -used VERB B-O -rat NOUN B-O -model NOUN B-O -of ADP B-O -adjuvant NOUN B-LF -- PUNCT I-LF -induced VERB I-LF -arthritis NOUN I-LF -( PUNCT B-O -AIA PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Two NUM B-O -modalities NOUN B-O -of ADP B-O -cryotherapy NOUN B-O -were AUX B-O -compared VERB B-O -: PUNCT B-O -local ADJ B-O -ice NOUN B-O -and CCONJ B-O -cold ADJ B-O -spray NOUN B-O -application NOUN B-O -. PUNCT B-O - -HRs PROPN B-AC -were AUX B-O -adjusted VERB B-O -for ADP B-O -age NOUN B-O -, PUNCT B-O -sex NOUN B-O -, PUNCT B-O -total ADJ B-O -energy NOUN B-O -intake NOUN B-O -, PUNCT B-O -education NOUN B-O -, PUNCT B-O -physical ADJ B-O -activity NOUN B-O -, PUNCT B-O -smoking NOUN B-O -status NOUN B-O -, PUNCT B-O -alcohol NOUN B-O -intake NOUN B-O -, PUNCT B-O -and CCONJ B-O -BMI PROPN B-AC -. PUNCT B-O - -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -HR PROPN B-AC -, PUNCT B-O -hazard NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -MetS PROPN B-AC -, PUNCT B-O -metabolic ADJ B-LF -syndrome NOUN I-LF -; PUNCT B-O -uPDI PROPN B-AC -, PUNCT B-O -unhealthful ADJ B-LF -plant NOUN I-LF -- PUNCT I-LF -based VERB I-LF -diet NOUN I-LF -index NOUN I-LF -. PUNCT B-O - -CHW PROPN B-AC -, PUNCT B-O -community NOUN B-LF -health NOUN I-LF -worker NOUN I-LF -; PUNCT B-O -DV PROPN B-O -, PUNCT B-O -drug NOUN B-O -vendor NOUN B-O -/ SYM B-O -shop NOUN B-O -; PUNCT B-O -HP PROPN B-O -, PUNCT B-O -healthcare NOUN B-O -provider NOUN B-O -; PUNCT B-O -MA PROPN B-O -, PUNCT B-O -medical ADJ B-O -assistant NOUN B-O -; PUNCT B-O -MD PROPN B-O -, PUNCT B-O -medical ADJ B-O -doctor NOUN B-O -; PUNCT B-O -NA PROPN B-O -, PUNCT B-O -not PART B-O -reported VERB B-O -by ADP B-O -study NOUN B-O -authors NOUN B-O -; PUNCT B-O -pharm NOUN B-O -, PUNCT B-O -pharmacist NOUN B-O -( PUNCT B-O -trained VERB B-O -) PUNCT B-O -; PUNCT B-O -PSI PROPN B-O -, PUNCT B-O -Population PROPN B-O -Services PROPN B-O -International PROPN B-O -Research PROPN B-O -and CCONJ B-O -Metrics PROPN B-O -; PUNCT B-O -PW PROPN B-O -, PUNCT B-O -pregnant ADJ B-O -women NOUN B-O -. PUNCT B-O - -This DET B-O -study NOUN B-O -was AUX B-O -undertaken VERB B-O -in ADP B-O -Kenyatta PROPN B-LF -National PROPN I-LF -Hospital PROPN I-LF -( PUNCT B-O -KNH PROPN B-AC -) PUNCT B-O --the DET B-O -largest ADJ B-O -public ADJ B-O -tertiary ADJ B-O -referral NOUN B-O -centre NOUN B-O -in ADP B-O -East PROPN B-O -& CCONJ B-O -Central PROPN B-O -Africa PROPN B-O -— PUNCT B-O -to PART B-O -help AUX B-O -bridge VERB B-O -existing VERB B-O -AMR PROPN B-AC -knowledge NOUN B-O -and CCONJ B-O -practice NOUN B-O -gaps NOUN B-O -. PUNCT B-O - -We PRON B-O -extracted VERB B-O -individuals NOUN B-O -’ PUNCT B-O -demographic ADJ B-O -and CCONJ B-O -residential ADJ B-O -information NOUN B-O -, PUNCT B-O -including VERB B-O -age NOUN B-O -, PUNCT B-O -sex NOUN B-O -, PUNCT B-O -residence NOUN B-O -, PUNCT B-O -income NOUN B-O -quintile NOUN B-O -, PUNCT B-O -and CCONJ B-O -whether SCONJ B-O -the DET B-O -individual NOUN B-O -was AUX B-O -resident NOUN B-O -of ADP B-O -a DET B-O -long ADJ B-LF -- PUNCT I-LF -term NOUN I-LF -care NOUN I-LF -( PUNCT B-O -LTC PROPN B-AC -) PUNCT B-O -facility NOUN B-O -90 NUM B-O -days NOUN B-O -prior ADV B-O -to ADP B-O -the DET B-O -testing NOUN B-O -date NOUN B-O -from ADP B-O -the DET B-O -database NOUN B-O -. PUNCT B-O - -The DET B-O -studied VERB B-O -responses NOUN B-O -( PUNCT B-O -dependent ADJ B-O -variables NOUN B-O -) PUNCT B-O -were AUX B-O -the DET B-O -dissolution NOUN B-LF -efficiency NOUN I-LF -% NOUN B-O -at ADP B-O -10 NUM B-O -min PROPN B-AC -( PUNCT B-O -Y1 PROPN B-O -: PUNCT B-O -DE PROPN B-AC -( PUNCT B-O -10 NUM B-O -min PROPN B-AC -) PUNCT B-O -% NOUN B-O -) PUNCT B-O -, PUNCT B-O -the DET B-O -dissolution NOUN B-LF -efficiency NOUN I-LF -% NOUN B-O -at ADP B-O -30 NUM B-O -min PROPN B-AC -( PUNCT B-O -Y2 PROPN B-O -: PUNCT B-O -DE PROPN B-AC -( PUNCT B-O -30 NUM B-O -min PROPN B-AC -) PUNCT B-O -% NOUN B-O -) PUNCT B-O -, PUNCT B-O -the DET B-O -mean ADJ B-LF -dissolution NOUN I-LF -time NOUN I-LF -( PUNCT B-O -Y3 NOUN B-O -: PUNCT B-O -MDT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -disintegration NOUN B-LF -time NOUN I-LF -( PUNCT B-O -Y4 PROPN B-O -: PUNCT B-O -DT PROPN B-AC -) PUNCT B-O -and CCONJ B-O -the DET B-O -wetting NOUN B-LF -time NOUN I-LF -( PUNCT B-O -Y5 NOUN B-O -: PUNCT B-O -WT PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Responses NOUN B-O -of ADP B-O -the DET B-O -prepared VERB B-O -ODTs PROPN B-AC -are AUX B-O -listed VERB B-O -in ADP B-O -Table NOUN B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -in ADP B-O -S1 PROPN B-O -File PROPN B-O -. PUNCT B-O - -This PRON B-O -is AUX B-O -in ADP B-O -contrast NOUN B-O -to ADP B-O -the DET B-O -traditional ADJ B-O -physician NOUN B-O -- PUNCT B-O -assessed VERB B-O -Expanded PROPN B-LF -Disability PROPN I-LF -Status PROPN I-LF -Scale PROPN I-LF -( PUNCT B-O -EDSS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -the DET B-O -primary ADJ B-O -outcome NOUN B-O -favoured VERB B-O -in ADP B-O -most ADJ B-O -MS PROPN B-AC -trials NOUN B-O -despite SCONJ B-O -several ADJ B-O -well ADV B-O -- PUNCT B-O -documented VERB B-O -limitations NOUN B-O -, PUNCT B-O -including VERB B-O -poor ADJ B-O -interrater NOUN B-O -and CCONJ B-O -intrarater ADJ B-O -reliability NOUN B-O -and CCONJ B-O -a DET B-O -limited ADJ B-O -sensitivity NOUN B-O -to ADP B-O -change NOUN B-O -over ADP B-O -the DET B-O -time NOUN B-O -frame NOUN B-O -of ADP B-O -2–3 NUM B-O -years NOUN B-O -, PUNCT B-O -especially ADV B-O -in ADP B-O -progressive ADJ B-O -MS PROPN B-AC -[ PUNCT B-O -16–20 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Compared VERB B-O -with ADP B-O -LPS PROPN B-AC -alone ADV B-O -, PUNCT B-O -at ADP B-O -Vm PROPN B-AC -values NOUN B-O -negative ADJ B-O -from ADP B-O -the DET B-O -reversal NOUN B-LF -NCX PROPN B-AC -potential NOUN I-LF -( PUNCT B-O -Erev PROPN B-AC -) PUNCT B-O -, PUNCT B-O -additional ADJ B-O -HS PROPN B-AC -exposure NOUN B-O -enhanced VERB B-O -NCX PROPN B-AC -inward ADJ B-O -current NOUN B-O -( PUNCT B-O -Fig PROPN B-O -4C NUM B-O -) PUNCT B-O -. PUNCT B-O - -Altogether ADV B-O -, PUNCT B-O -this PRON B-O -suggests VERB B-O -that SCONJ B-O -NCX PROPN B-AC -mediates VERB B-O -Na+ NOUN B-O -entry NOUN B-O -. PUNCT B-O - -The DET B-O -location NOUN B-O -of ADP B-O -weaker ADJ B-O -lipid NOUN B-O -binding VERB B-O -sites NOUN B-O -is AUX B-O -therefore ADV B-O -usually ADV B-O -observed VERB B-O -using VERB B-O -classical ADJ B-O -molecular ADJ B-LF -dynamics NOUN I-LF -( PUNCT B-O -MD PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -A DET B-O -planned VERB B-O -individual ADJ B-LF -participant NOUN I-LF -data NOUN I-LF -( PUNCT B-O -IPD PROPN B-AC -) PUNCT B-O -meta NOUN B-O -- NOUN B-O -analysis NOUN B-O -( PUNCT B-O -PROSPERO PROPN B-O -CRD42017072683 NUM B-O -) PUNCT B-O -may AUX B-O -prove VERB B-O -helpful ADJ B-O -to PART B-O -further ADV B-O -explore VERB B-O -possible ADJ B-O -sex NOUN B-O -differences NOUN B-O -in ADP B-O -the DET B-O -effects NOUN B-O -of ADP B-O -macronutrient NOUN B-O -supplements NOUN B-O -in ADP B-O -human ADJ B-O -infants NOUN B-O -born VERB B-O -small ADJ B-O -. PUNCT B-O - -We PRON B-O -used VERB B-O -a DET B-O -novel ADJ B-O -in ADP B-O -vitro X B-O -assay NOUN B-O -( PUNCT B-O -for ADP B-O -gamma NOUN B-LF -- NOUN I-LF -interferon NOUN I-LF -[ PUNCT B-O -IFN-γ PROPN B-AC -] PUNCT B-O -) PUNCT B-O -release NOUN B-O -to PART B-O -establish VERB B-O -LTBI PROPN B-AC -and CCONJ B-O -a DET B-O -questionnaire NOUN B-O -to PART B-O -address VERB B-O -risk NOUN B-O -factors NOUN B-O -. PUNCT B-O - -Fenland PROPN B-O -Study PROPN B-O -participants NOUN B-O -undergo VERB B-O -a DET B-O -health NOUN B-O -assessment NOUN B-O -, PUNCT B-O -and CCONJ B-O -blood NOUN B-O -samples NOUN B-O -are AUX B-O -collected VERB B-O -for ADP B-O -the DET B-O -genotyping NOUN B-O -of ADP B-O -single ADJ B-LF -nucleotide NOUN I-LF -polymorphisms NOUN I-LF -( PUNCT B-O -SNPs PROPN B-AC -) PUNCT B-O -associated VERB B-O -with ADP B-O -type NOUN B-O -2 NUM B-O -diabetes NOUN B-O -. PUNCT B-O - -The DET B-O -ratio NOUN B-LF -of ADP I-LF -nonsynonymous ADJ I-LF -to PART I-LF -synonymous ADJ I-LF -substitutions NOUN I-LF -( PUNCT B-O -dN/dS PROPN B-AC -) PUNCT B-O -was AUX B-O -calculated VERB B-O -in ADP B-O -phylogenetic ADJ B-LF -analysis NOUN I-LF -by ADP I-LF -maximum ADJ I-LF -likelihood NOUN I-LF -( PUNCT B-O -PAML PROPN B-AC -) PUNCT B-O -software NOUN B-O -[ X B-O -39 X B-O -] X B-O -using VERB B-O -a DET B-O -two NUM B-O -- PUNCT B-O -ratio NOUN B-O -maximum ADJ B-O -- PUNCT B-O -likelihood NOUN B-O -analysis NOUN B-O -between ADP B-O -the DET B-O -human ADJ B-LF -haplotype NOUN I-LF -'s PART I-LF -most ADV I-LF -recent ADJ I-LF -common ADJ I-LF -ancestor NOUN I-LF -( PUNCT B-O -HH PROPN B-AC -) PUNCT B-O -and CCONJ B-O -the DET B-O -human ADJ B-O -- PUNCT B-O -chimpanzee NOUN B-O --MRCAMRCA PROPN B-AC -( PUNCT B-O -Figure PROPN B-O -5B NUM B-O -) PUNCT B-O -. PUNCT B-O - -This DET B-O -measurement NOUN B-O -, PUNCT B-O -which PRON B-O -only ADV B-O -evaluates VERB B-O -fixed VERB B-O -changes NOUN B-O -, PUNCT B-O -is AUX B-O -used VERB B-O -to PART B-O -determine VERB B-O -selective ADJ B-O -pressures NOUN B-O -in ADP B-O -a DET B-O -coding VERB B-O -region NOUN B-O -, PUNCT B-O -where SCONJ B-O -values NOUN B-O -> ADP B-O -1 NUM B-O -suggest VERB B-O -positive ADJ B-O -selection NOUN B-O -, PUNCT B-O -while SCONJ B-O -values NOUN B-O -< ADP B-O -1 NUM B-O -indicate VERB B-O -purifying VERB B-O -selection NOUN B-O -. PUNCT B-O - -Fig NOUN B-O -5 NUM B-O -shows VERB B-O -immunohistochemistry NOUN B-LF -( PUNCT B-O -IHC PROPN B-AC -) PUNCT B-O -results NOUN B-O -in ADP B-O -benign ADJ B-O -prostate NOUN B-O -tissue NOUN B-O -and CCONJ B-O -prostate NOUN B-O -adenocarcinoma NOUN B-O -according VERB B-O -to ADP B-O -pT NOUN B-O -stage NOUN B-O -and CCONJ B-O -Gleason PROPN B-O -score NOUN B-O -. PUNCT B-O - -Among ADP B-O -the DET B-O -approximately ADV B-O -70 NUM B-O -members NOUN B-O -in ADP B-O -the DET B-O -TRIM PROPN B-AC -family NOUN B-O -, PUNCT B-O -TRIM59 PROPN B-O -stood VERB B-O -out ADP B-O -as ADP B-O -one NUM B-O -of ADP B-O -the DET B-O -most ADV B-O -differentially ADV B-O -expressed VERB B-O -genes NOUN B-O -, PUNCT B-O -with ADP B-O -its PRON B-O -expression NOUN B-O -ubiquitously ADV B-O -up ADV B-O -- ADJ B-O -regulated VERB B-O -by ADP B-O -1.6- NUM B-O -to PART B-O -6.3 NUM B-O -- ADJ B-O -fold NOUN B-O -in ADP B-O -12 NUM B-O -analyzed VERB B-O -cancer NOUN B-O -types NOUN B-O -compared VERB B-O -with ADP B-O -the DET B-O -adjacent ADJ B-O -normal ADJ B-O -tissues NOUN B-O -( PUNCT B-O -Figs PROPN B-O -1A NOUN B-O -and CCONJ B-O -S1A PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Particularly ADV B-O -, PUNCT B-O -in ADP B-O -breast NOUN B-LF -invasive ADJ I-LF -carcinoma NOUN I-LF -( PUNCT B-O -BRCA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -TRIM59 PROPN B-O -mRNA NOUN B-O -level NOUN B-O -was AUX B-O -significantly ADV B-O -increased VERB B-O -in ADP B-O -tumor NOUN B-O -sites NOUN B-O -( PUNCT B-O -red ADJ B-O -plot NOUN B-O -) PUNCT B-O -compared VERB B-O -with ADP B-O -its PRON B-O -expression NOUN B-O -in ADP B-O -normal ADJ B-O -adjacent ADJ B-O -tissues NOUN B-O -( PUNCT B-O -blue ADJ B-O -plot NOUN B-O -; PUNCT B-O -fold NOUN B-O -change NOUN B-O -= SYM B-O -4.03 NUM B-O -, PUNCT B-O -P NOUN B-O -value NOUN B-O -= SYM B-O -2.9 NUM B-O -× PUNCT B-O -10−28 NUM B-O -; PUNCT B-O -S1A PROPN B-O -Fig PROPN B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -analyses NOUN B-O -of ADP B-O -frailty NOUN B-O -categories NOUN B-O -, PUNCT B-O -only ADV B-O -the DET B-O -G-8 PROPN B-LF -Geriatric PROPN I-LF -Screening PROPN I-LF -Tool PROPN I-LF -( PUNCT B-O -G8 PROPN B-AC -) PUNCT B-O -score NOUN B-O -added VERB B-O -statistically ADV B-O -significant ADJ B-O -predictive ADJ B-O -value NOUN B-O -( PUNCT B-O -delta NOUN B-O -C NOUN B-O -: PUNCT B-O -1.6 NUM B-O -[ PUNCT B-O -95 NUM B-O -% NOUN B-O -CI NOUN B-O -: PUNCT B-O -0.4–2.8 NUM B-O -] PUNCT B-O -) PUNCT B-O -( PUNCT B-O -S10 PROPN B-O -Table PROPN B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -March PROPN B-O -2016 NUM B-O -, PUNCT B-O -HRSA PROPN B-AC -awarded VERB B-O -$ SYM B-O -94 NUM B-O -million NUM B-O -through ADP B-O -the DET B-O -Substance PROPN B-LF -Abuse PROPN I-LF -Service PROPN I-LF -Expansion PROPN I-LF -( PUNCT B-O -SASE PROPN B-AC -) PUNCT B-O -supplemental ADJ B-O -grants NOUN B-O -to ADP B-O -271 NUM B-O -or CCONJ B-O -20 NUM B-O -% NOUN B-O -of ADP B-O -HCs PROPN B-AC -, PUNCT B-O -with ADP B-O -supplementary ADJ B-O -funding NOUN B-O -ranging VERB B-O -from ADP B-O -$ SYM B-O -217,000 NUM B-O -to ADP B-O -$ SYM B-O -406,000 NUM B-O -. PUNCT B-O - -FisB PROPN B-AC -, PUNCT B-O -fission NOUN B-LF -protein NOUN I-LF -B. NOUN I-LF -Consistent ADJ B-O -with ADP B-O -this PRON B-O -, PUNCT B-O -ICP47 PROPN B-O -protects VERB B-O -HSV PROPN B-AC -- PUNCT B-O -infected VERB B-O -human ADJ B-O -fibroblasts NOUN B-O -from ADP B-O -destruction NOUN B-O -by ADP B-O -cytotoxic ADJ B-LF -T PROPN I-LF -lymphocytes NOUN I-LF -( PUNCT B-O -CTLs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -while SCONJ B-O -murine ADJ B-O -fibroblasts NOUN B-O -are AUX B-O -not PART B-O -protected VERB B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -These DET B-O -data NOUN B-O -were AUX B-O -then ADV B-O -analyzed VERB B-O -via ADP B-O -a DET B-O -one NUM B-O -- PUNCT B-O -way NOUN B-O -repeated VERB B-O -measures NOUN B-O -analysis NOUN B-LF -of ADP I-LF -variance NOUN I-LF -( PUNCT B-O -ANOVA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -with ADP B-O -Fisher PROPN B-O -’s PART B-O -post X B-O -hoc X B-O -analysis NOUN B-O -of ADP B-O -each DET B-O -experimental ADJ B-O -treatment NOUN B-O -group NOUN B-O -compared VERB B-O -to ADP B-O -vehicle NOUN B-O -following VERB B-O -a DET B-O -significant ADJ B-O -ANOVA PROPN B-AC -( PUNCT B-O -P NOUN B-O -< ADP B-O -0.05 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -plotted VERB B-O -as ADP B-O -a DET B-O -mean NOUN B-O -± ADJ B-O -S.E.M. NOUN B-O -for ADP B-O -the DET B-O -group NOUN B-O -. PUNCT B-O - -We PRON B-O -have AUX B-O -also ADV B-O -challenged VERB B-O -our PRON B-O -whole ADJ B-O -blood NOUN B-O -samples NOUN B-O -with ADP B-O -either CCONJ B-O -intact ADJ B-O -bacterial ADJ B-O -( PUNCT B-O -E.coli PROPN B-AC -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -virus NOUN B-O -( PUNCT B-O -HSV-1 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -rather ADV B-O -than ADP B-O -specific ADJ B-O -Toll NOUN B-LF -like ADP I-LF -receptor NOUN I-LF -( PUNCT B-O -TLR PROPN B-AC -) PUNCT B-O -agonists NOUN B-O -like ADP B-O -lipopolysaccharide NOUN B-LF -( PUNCT B-O -LPS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -since SCONJ B-O -we PRON B-O -considered VERB B-O -intact ADJ B-O -pathogens NOUN B-O -more ADV B-O -representative ADJ B-O -of ADP B-O -in X B-O -vivo X B-O -infections NOUN B-O -. PUNCT B-O - -* PUNCT B-O -Value NOUN B-O -of ADP B-O -% NOUN B-O -DNA NOUN B-LF -repair NOUN I-LF -capacity NOUN I-LF -( PUNCT B-O -DRC PROPN B-AC -) PUNCT B-O -measured VERB B-O -in ADP B-O -lymphocytes NOUN B-O -expressed VERB B-O -as ADP B-O -mean NOUN B-O -( PUNCT B-O -X NOUN B-O -¯ NOUN B-O -) PUNCT B-O -, PUNCT B-O -± NOUN B-O -1 NUM B-O -standard ADJ B-O -deviation NOUN B-O -( PUNCT B-O -SD NOUN B-O -) PUNCT B-O -and CCONJ B-O -median ADJ B-O -values NOUN B-O -including VERB B-O -percentile NOUN B-O -25 NUM B-O -( PUNCT B-O -P25 NUM B-O -) PUNCT B-O -and CCONJ B-O -percentile NOUN B-O -75 NUM B-O -( PUNCT B-O -P75 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Those DET B-O -incident NOUN B-O -cases NOUN B-O -with ADP B-O -sequelae NOUN B-O -( PUNCT B-O -or CCONJ B-O -diseased ADJ B-O -individuals NOUN B-O -) PUNCT B-O -were AUX B-O -assigned VERB B-O -years NOUN B-LF -of ADP I-LF -life NOUN I-LF -lost VERB I-LF -( PUNCT B-O -YLLs PROPN B-AC -) PUNCT B-O -if SCONJ B-O -fatal ADJ B-O -or CCONJ B-O -years NOUN B-LF -lived VERB I-LF -with ADP I-LF -disability NOUN I-LF -( PUNCT B-O -YLDs PROPN B-AC -) PUNCT B-O -with ADP B-O -a DET B-O -disability NOUN B-LF -weight NOUN I-LF -( PUNCT B-O -DW PROPN B-AC -) PUNCT B-O -that PRON B-O -depended VERB B-O -on ADP B-O -the DET B-O -severity NOUN B-O -of ADP B-O -the DET B-O -disease NOUN B-O -. PUNCT B-O - -Nutrient NOUN B-O -intake NOUN B-O -stimulates VERB B-O -production NOUN B-O -of ADP B-O -circulating VERB B-O -Drosophila PROPN B-LF -insulin NOUN I-LF -- PUNCT I-LF -like ADJ I-LF -peptides NOUN I-LF -( PUNCT B-O -Dilps PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -activate VERB B-O -the DET B-O -insulin NOUN B-O -/ SYM B-O -IGF-1 PROPN B-AC -receptor NOUN B-O -( PUNCT B-O -InR PROPN B-O -) PUNCT B-O -, PUNCT B-O -leading VERB B-O -to ADP B-O -the DET B-O -recruitment NOUN B-O -of ADP B-O -the DET B-O -phosphatidyl NOUN B-LF -inositol-3 NOUN I-LF -- PUNCT I-LF -kinase NOUN I-LF -( PUNCT B-O -PI3K PROPN B-AC -— PUNCT B-O -composed VERB B-O -of ADP B-O -two NUM B-O -subunits NOUN B-O -, PUNCT B-O -p60 NOUN B-O -and CCONJ B-O -p110 NOUN B-O -) PUNCT B-O -, PUNCT B-O -which PRON B-O -coverts VERB B-O -phosphatidyl NOUN B-LF -inositol NOUN I-LF -phosphate NOUN I-LF -( PUNCT B-O -PIP)2 PROPN B-AC -to ADP B-O -PIP3 PROPN B-O -at ADP B-O -the DET B-O -plasma NOUN B-O -membrane NOUN B-O -of ADP B-O -signal NOUN B-O -- PUNCT B-O -receiving VERB B-O -cells NOUN B-O -( PUNCT B-O -a DET B-O -process NOUN B-O -antagonised VERB B-O -by ADP B-O -the DET B-O -phosphatase NOUN B-LF -and CCONJ I-LF -tensin NOUN I-LF -homolog NOUN I-LF -PTEN PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -3 NUM B-O -, PUNCT B-O -20–30 NUM B-O -] PUNCT B-O -. PUNCT B-O - -AMR PROPN B-AC -, PUNCT B-O -asthma NOUN B-LF -medication NOUN I-LF -ratio NOUN I-LF -; PUNCT B-O -CI PROPN B-O -, PUNCT B-O -confidence NOUN B-O -interval NOUN B-O -; PUNCT B-O -GAM PROPN B-AC -, PUNCT B-O -generalised ADJ B-LF -additive ADJ I-LF -model NOUN I-LF -; PUNCT B-O -WIMD PROPN B-AC -, PUNCT B-O -Welsh PROPN B-LF -Index PROPN I-LF -of ADP I-LF -Multiple PROPN I-LF -Deprivation PROPN I-LF -. PUNCT B-O - -ALT PROPN B-AC -serum NOUN B-O -concentration NOUN B-O -was AUX B-O -analyzed VERB B-O -as SCONJ B-O -categorical ADJ B-O -variable NOUN B-O -in ADP B-O -this DET B-O -model NOUN B-O -, PUNCT B-O -as SCONJ B-O -indicated VERB B-O -. PUNCT B-O - -w PROPN B-O -, PUNCT B-O -women NOUN B-O -; PUNCT B-O -m PROPN B-O -, PUNCT B-O -men NOUN B-O -; PUNCT B-O -ALT PROPN B-AC -, PUNCT B-O -alanine NOUN B-LF -aminotransferase NOUN I-LF -; PUNCT B-O -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -γGT PROPN B-O -, PUNCT B-O -γ PUNCT B-O -- PUNCT B-O -glutamyl NOUN B-O -transferase NOUN B-O -; PUNCT B-O -IFN PROPN B-AC -, PUNCT B-O -interferon NOUN B-LF -; PUNCT B-O -INR PROPN B-AC -, PUNCT B-O -international ADJ B-LF -normalized ADJ I-LF -ratio NOUN I-LF -; PUNCT B-O -IFN PROPN B-AC -, PUNCT B-O -interferon NOUN B-LF -; PUNCT B-O -ULN PROPN B-AC -, PUNCT B-O -upper ADJ B-LF -limit NOUN I-LF -of ADP I-LF -normal ADJ I-LF -. PUNCT B-O - -In ADP B-O -spite NOUN B-O -of ADP B-O -the DET B-O -considerable ADJ B-O -body NOUN B-O -of ADP B-O -research NOUN B-O -on ADP B-O -NDDs PROPN B-AC -such ADJ B-O -as ADP B-O -Alzheimer PROPN B-LF -’s PART I-LF -disease NOUN I-LF -( PUNCT B-O -AD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -amyotrophic ADJ B-LF -lateral ADJ I-LF -sclerosis NOUN I-LF -( PUNCT B-O -ALS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Huntington PROPN B-LF -’s PART I-LF -disease NOUN I-LF -( PUNCT B-O -HD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -multiple ADJ B-LF -sclerosis NOUN I-LF -( PUNCT B-O -MS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Parkinson PROPN B-LF -’s PART I-LF -disease NOUN I-LF -( PUNCT B-O -PD PROPN B-AC -) PUNCT B-O -and CCONJ B-O -schizophrenia NOUN B-LF -( PUNCT B-O -SCHIZ PROPN B-AC -) PUNCT B-O -, PUNCT B-O -effective ADJ B-O -treatment NOUN B-O -for ADP B-O -preventing VERB B-O -the DET B-O -progressive ADJ B-O -neuronal ADJ B-O -loss NOUN B-O -is AUX B-O -yet ADV B-O -to PART B-O -be AUX B-O -available ADJ B-O -[ PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -LAM PROPN B-AC -, PUNCT B-O -lipoarabinomannan NOUN B-LF -assay NOUN I-LF -; PUNCT B-O -TB PROPN B-AC -, PUNCT B-O -tuberculosis NOUN B-LF -; PUNCT B-O -Xpert PROPN B-AC -, PUNCT B-O -Xpert PROPN B-LF -MTB PROPN I-LF -Xpert PROPN B-AC -/ SYM I-LF -MTB PROPN B-AC -RIF PROPN I-LF -assay NOUN I-LF -. PUNCT B-O - -“ PUNCT B-O -… PUNCT B-O -any DET B-O -work NOUN B-O -[ X B-O -done VERB B-O -] X B-O -PA PROPN B-AC -[ X B-O -posteroanterior ADJ B-LF -] X B-O -, PUNCT B-O -especially ADV B-O -chests NOUN B-O -, PUNCT B-O -I PRON B-O -always ADV B-O -like ADP B-O -to PART B-O -have AUX B-O -a DET B-O -[ X B-O -radiopaque ADJ B-O -] X B-O -marker NOUN B-O -on ADP B-O -, PUNCT B-O -or CCONJ B-O -sinuses NOUN B-O -or CCONJ B-O -skulls NOUN B-O -because SCONJ B-O -if SCONJ B-O -you PRON B-O -do AUX B-O -get VERB B-O -dextrocardia NOUN B-O -or CCONJ B-O -something PRON B-O -like ADP B-O -that SCONJ B-O -… PUNCT B-O -you PRON B-O -can AUX B-O -stand VERB B-O -in ADP B-O -front NOUN B-O -of ADP B-O -the DET B-O -… PUNCT B-O -film NOUN B-O -[ X B-O -detector NOUN B-O -] X B-O -where SCONJ B-O -your PRON B-O -marker NOUN B-O -was AUX B-O -and CCONJ B-O -check VERB B-O -, PUNCT B-O -was AUX B-O -it PRON B-O -a DET B-O -left NOUN B-O -or CCONJ B-O -right NOUN B-O -and CCONJ B-O -then ADV B-O -double ADV B-O -check VERB B-O -yourself PRON B-O -that SCONJ B-O -you PRON B-O -have AUX B-O -actually ADV B-O -labelled VERB B-O -it PRON B-O -correctly ADV B-O -. PUNCT B-O - -Fluorescence NOUN B-LF -- PUNCT I-LF -activated VERB I-LF -cell NOUN I-LF -sorting NOUN I-LF -( PUNCT B-O -FACS PROPN B-AC -) PUNCT B-O -sorting NOUN B-O -to PART B-O -enrich VERB B-O -for ADP B-O -glioma NOUN B-O -stem NOUN B-O -cells NOUN B-O -has AUX B-O -relied VERB B-O -on ADP B-O -the DET B-O -presence NOUN B-O -of ADP B-O -the DET B-O -glycosylated VERB B-O -form NOUN B-O -of ADP B-O -the DET B-O -cell NOUN B-O -surface NOUN B-O -marker NOUN B-O -CD133 NOUN B-O -( PUNCT B-O -Prominin-1 NOUN B-O -): PUNCT B-O -a DET B-O -protein NOUN B-O -whose DET B-O -role NOUN B-O -in ADP B-O -tumorigenesis NOUN B-O -and CCONJ B-O -glioma NOUN B-O -biology NOUN B-O -remains VERB B-O -unclear ADJ B-O -[ PUNCT B-O -27 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Among ADP B-O -the DET B-O -methodologies NOUN B-O -used VERB B-O -to ADP B-O -ascertain VERB B-O -cause NOUN B-LF -of ADP I-LF -death NOUN I-LF -( PUNCT B-O -CoD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -those PRON B-O -derived VERB B-O -from ADP B-O -the DET B-O -verbal ADJ B-O -autopsy NOUN B-O -lack VERB B-O -specificity NOUN B-O -with ADP B-O -regard NOUN B-O -to ADP B-O -most ADJ B-O -biological ADJ B-O -causes NOUN B-O -of ADP B-O -death NOUN B-O -. PUNCT B-O - -EASI PROPN B-AC -, PUNCT B-O -Eczema PROPN B-LF -Area PROPN I-LF -and CCONJ I-LF -Severity PROPN I-LF -Index PROPN I-LF -. PUNCT B-O - -We PRON B-O -found VERB B-O -biological ADJ B-O -factors NOUN B-O -including VERB B-O -girls NOUN B-O -experiencing VERB B-O -early ADJ B-O -menarche NOUN B-O -, PUNCT B-O -having VERB B-O -lighter ADJ B-O -periods NOUN B-O -, PUNCT B-O -and CCONJ B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -; PUNCT B-O -household NOUN B-O -level NOUN B-O -factors NOUN B-O -including VERB B-O -being AUX B-O -unhappy ADJ B-O -at ADP B-O -home NOUN B-O -, PUNCT B-O -being AUX B-O -orphaned VERB B-O -, PUNCT B-O -and CCONJ B-O -coming VERB B-O -from ADP B-O -poorer ADJ B-O -households NOUN B-O -; PUNCT B-O -and CCONJ B-O -social ADJ B-O -factors NOUN B-O -including VERB B-O -experiencing VERB B-O -harassment NOUN B-O -for ADP B-O -sex NOUN B-O -both PRON B-O -in ADP B-O -and CCONJ B-O -out ADP B-O -of ADP B-O -school NOUN B-O -or CCONJ B-O -being AUX B-O -touched VERB B-O -indecently ADV B-O -were AUX B-O -significantly ADV B-O -associated VERB B-O -with ADP B-O -girls NOUN B-O -’ PUNCT B-O -sexual ADJ B-O -and CCONJ B-O -reproductive ADJ B-O -harms NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -pregnancy NOUN B-O -, PUNCT B-O -HSV-2 PROPN B-AC -, PUNCT B-O -and/or CCONJ B-O -HIV PROPN B-O -. PUNCT B-O - -L1 PROPN B-O -, PUNCT B-O -L2 PROPN B-O -, PUNCT B-O -L3 PROPN B-O -= PUNCT B-O -Languages NOUN B-O -1–3 NUM B-O -. PUNCT B-O - -fMRI PROPN B-AC -, PUNCT B-O -functional ADJ B-LF -MRI NOUN I-LF -; PUNCT B-O -lPL PROPN B-AC -, PUNCT B-O -left ADJ B-LF -parietal ADJ I-LF -lobe NOUN I-LF -; PUNCT B-O -POz PROPN B-AC -, PUNCT B-O -midline ADJ B-LF -posterior ADJ I-LF -location NOUN I-LF -according VERB I-LF -to ADP I-LF -the DET I-LF -10–20 NUM I-LF -system NOUN I-LF -electrode NOUN I-LF -location NOUN I-LF -; PUNCT B-O -rTMS PROPN B-AC -, PUNCT B-O -repetitive ADJ B-LF -transcranial ADJ I-LF -magnetic ADJ I-LF -stimulation NOUN I-LF -. PUNCT B-O - -SFM PROPN B-AC -shows VERB B-O -result NOUN B-O -of ADP B-O -serum NOUN B-LF -free ADJ I-LF -medium NOUN I-LF -alone ADV B-O -( PUNCT B-O -baseline NOUN B-O -control NOUN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -thalamus NOUN B-O -expression NOUN B-O -domain NOUN B-O -of ADP B-O -lhx9 NOUN B-O -overlaps VERB B-O -with ADP B-O -the DET B-O -pattern NOUN B-O -of ADP B-O -id2a NOUN B-O -in ADP B-O -the DET B-O -medial ADJ B-O -part NOUN B-O -of ADP B-O -the DET B-O -mantle NOUN B-LF -zone NOUN I-LF -( PUNCT B-O -g NOUN B-O -, PUNCT B-O -g′ NOUN B-O -, PUNCT B-O -black ADJ B-O -bar NOUN B-O -) PUNCT B-O -. PUNCT B-O - -lef1 NOUN B-O -as ADP B-O -a DET B-O -marker NOUN B-O -of ADP B-O -post ADJ B-O -- NOUN B-O -mitotic ADJ B-O -thalamic ADJ B-O -neurons NOUN B-O -shows VERB B-O -co NOUN B-O -- NOUN B-O -expression NOUN B-O -with ADP B-O -lhx9 NOUN B-O -in ADP B-O -the DET B-O -MZ PROPN B-AC -( PUNCT B-O -i NOUN B-O -, PUNCT B-O -i′ NOUN B-O -; PUNCT B-O -black ADJ B-O -bar NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Two NUM B-O -- PUNCT B-O -month NOUN B-O -- PUNCT B-O -old ADJ B-O -Thy1 PROPN B-O -- PUNCT B-O -YFP PROPN B-AC -transgenic VERB B-O -mice NOUN B-O -expressing VERB B-O -yellow ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -YFP PROPN B-AC -) PUNCT B-O -in ADP B-O -layer NOUN B-LF -5 NUM I-LF -( PUNCT B-O -L5 PROPN B-AC -) PUNCT B-O -pyramidal ADJ B-O -neurons NOUN B-O -were AUX B-O -repeatedly ADV B-O -imaged VERB B-O -before ADP B-O -and CCONJ B-O -1 NUM B-O -to ADP B-O -4 NUM B-O -weeks NOUN B-O -after ADP B-O -peripheral ADJ B-O -nerve NOUN B-O -injury NOUN B-O -( PUNCT B-O -Fig NOUN B-O -3A NUM B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -the DET B-O -region NOUN B-O -of ADP B-O -S1 PROPN B-AC -corresponding VERB B-O -to ADP B-O -the DET B-O -SNI PROPN B-AC -surgery NOUN B-O -side NOUN B-O -, PUNCT B-O -we PRON B-O -found VERB B-O -a DET B-O -significant ADJ B-O -increase NOUN B-O -in ADP B-O -the DET B-O -elimination NOUN B-O -and CCONJ B-O -formation NOUN B-O -rates NOUN B-O -of ADP B-O -dendritic ADJ B-O -spines NOUN B-O -( PUNCT B-O -Fig NOUN B-O -3B NUM B-O -and CCONJ B-O -3C NUM B-O -) PUNCT B-O -. PUNCT B-O - -Within ADP B-O -the DET B-O -first ADJ B-O -week NOUN B-O -after ADP B-O -surgery NOUN B-O -, PUNCT B-O -7.7 NUM B-O -± SYM B-O -0.6 NUM B-O -% NOUN B-O -of ADP B-O -dendritic ADJ B-O -spines NOUN B-O -were AUX B-O -eliminated VERB B-O -and CCONJ B-O -8.1 NUM B-O -± SYM B-O -0.5 NUM B-O -% NOUN B-O -were AUX B-O -formed VERB B-O -in ADP B-O -sham ADJ B-O -mice NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -11.4 NUM B-O -± SYM B-O -1.1 NUM B-O -% NOUN B-O -and CCONJ B-O -11.9 NUM B-O -± SYM B-O -1.1 NUM B-O -% NOUN B-O -of ADP B-O -dendritic ADJ B-O -spines NOUN B-O -were AUX B-O -eliminated VERB B-O -and CCONJ B-O -formed VERB B-O -in ADP B-O -SNI PROPN B-AC -mice NOUN B-O -, PUNCT B-O -respectively ADV B-O -. PUNCT B-O - -Inhibitor-2 NOUN B-LF -( PUNCT B-O -I-2 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -highly ADV B-O -conserved ADJ B-O -protein NOUN B-O -, PUNCT B-O -interacts VERB B-O -with ADP B-O -the DET B-O -catalytic ADJ B-O -subunit NOUN B-O -of ADP B-O -protein NOUN B-LF -phosphatase NOUN I-LF -1 NUM I-LF -( PUNCT B-O -PP1 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -inhibits VERB B-O -its PRON B-O -catalytic ADJ B-O -activity NOUN B-O -in ADP B-O -vitro ADV B-O -[ PUNCT B-O -33 NUM B-O -] PUNCT B-O -. PUNCT B-O - -HR NOUN B-O -, PUNCT B-O -Heart NOUN B-O -Rate NOUN B-O -; PUNCT B-O -SBP PROPN B-O -, PUNCT B-O -Systolic ADJ B-O -Blood NOUN B-O -Pressure NOUN B-O -; PUNCT B-O -DBP NOUN B-O -, PUNCT B-O -Diastolic ADJ B-O -Blood NOUN B-O -Pressure NOUN B-O -; PUNCT B-O -PP NOUN B-O -, PUNCT B-O -Pulse NOUN B-O -Pressure NOUN B-O -; PUNCT B-O -FFR PROPN B-AC -, PUNCT B-O -Fractional ADJ B-LF -Flow PROPN I-LF -reserve NOUN I-LF -; PUNCT B-O -CFVR PROPN B-AC -, PUNCT B-O -Coronary ADJ B-LF -Flow PROPN I-LF -Velocity PROPN I-LF -Reserve PROPN I-LF -; PUNCT B-O -sFCW PROPN B-AC -, PUNCT B-O -systolic ADJ B-LF -Forward ADJ I-LF -travelling VERB I-LF -Compression NOUN I-LF -Wave PROPN I-LF -; PUNCT B-O -dBEW PROPN B-AC -, PUNCT B-O -diastolic ADJ B-LF -Backward ADJ I-LF -travelling VERB I-LF -Expansion NOUN I-LF -Wave PROPN I-LF -( PUNCT B-O -Table PROPN B-O -C PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Univariate ADJ B-O -linear ADJ B-O -regression NOUN B-O -analyses NOUN B-O -of ADP B-O -baseline ADJ B-O -( PUNCT B-O -pre ADJ B-O -- ADJ B-O -PCI PROPN B-AC -) PUNCT B-O -sFCW PROPN B-AC -and CCONJ B-O -dBEW PROPN B-AC -cumulative ADJ B-O -intensity NOUN B-O -with ADP B-O -baseline ADJ B-O -haemodynamic ADJ B-O -and CCONJ B-O -patient ADJ B-O -variables NOUN B-O -. PUNCT B-O - -FRET PROPN B-AC -, PUNCT B-O -Förster PROPN B-LF -resonance NOUN I-LF -energy NOUN I-LF -transfer NOUN I-LF -; PUNCT B-O -GP PROPN B-AC -, PUNCT B-O -EBOV NOUN B-LF -envelope NOUN I-LF -EBOV PROPN B-AC -glycoprotein NOUN I-LF -; PUNCT B-O -GPΔmuc PROPN B-AC -, PUNCT B-O -GP PROPN B-LF -with ADP I-LF -GP PROPN B-AC -the DET I-LF -mucin NOUN I-LF -- PUNCT I-LF -like ADJ I-LF -domain NOUN I-LF -deleted VERB I-LF -; PUNCT B-O -MD PROPN B-AC -, PUNCT B-O -molecular ADJ B-LF -dynamics NOUN I-LF -. PUNCT B-O - -The DET B-O -apparent ADJ B-LF -digestibility NOUN I-LF -coefficients NOUN I-LF -( PUNCT B-O -ADCs PROPN B-AC -) PUNCT B-O -of ADP B-O -DM PROPN B-AC -, PUNCT B-O -protein NOUN B-O -, PUNCT B-O -lipid NOUN B-O -, PUNCT B-O -ash NOUN B-O -and CCONJ B-O -energy NOUN B-O -were AUX B-O -calculated VERB B-O -using VERB B-O -the DET B-O -following VERB B-O -equation NOUN B-O -[ X B-O -25 NUM B-O -] PUNCT B-O -: PUNCT B-O -ADCnutrientorenergy=[1−(Markerfeed×NutrientfaecesMarkerfaeces×Nutrientfeed)]×100(1 X B-O -) PUNCT B-O -ADCdry ADJ B-O -matter=[1−(MarkerfeedMarkerfaeces)]×100(2 X B-O -) PUNCT B-O -where SCONJ B-O -Markerfeed PROPN B-O -and CCONJ B-O -Markerfaeces NOUN B-O -are AUX B-O -the DET B-O -contents NOUN B-O -of ADP B-O -the DET B-O -marker NOUN B-O -( PUNCT B-O -% PUNCT B-O -dry ADJ B-LF -matter NOUN I-LF -) PUNCT B-O -in ADP B-O -the DET B-O -feed NOUN B-O -and CCONJ B-O -faeces NOUN B-O -, PUNCT B-O -respectively ADV B-O -, PUNCT B-O -and CCONJ B-O -Nutrientfeed PROPN B-O -and CCONJ B-O -Nutrientfaeces PROPN B-O -are AUX B-O -the DET B-O -nutrient NOUN B-O -contents NOUN B-O -( PUNCT B-O -% PUNCT B-O -dry ADJ B-LF -matter NOUN I-LF -) PUNCT B-O -in ADP B-O -the DET B-O -feed NOUN B-O -and CCONJ B-O -faeces NOUN B-O -. PUNCT B-O - -Excess ADJ B-LF -lung NOUN I-LF -weight NOUN I-LF -( PUNCT B-O -ELW PROPN B-AC -) PUNCT B-O -showed VERB B-O -highly ADV B-O -significant ADJ B-O -correlation NOUN B-O -with ADP B-O -parameters NOUN B-O -describing VERB B-O -inflation NOUN B-O -( PUNCT B-O -inflated VERB B-O -lung NOUN B-O -tissue NOUN B-O -[ X B-O -% X B-O -] X B-O -p NOUN B-O -= SYM B-O -0.0001 NUM B-O -r NOUN B-O -= SYM B-O --0.65 NUM B-O -) PUNCT B-O -, PUNCT B-O -haemodynamics NOUN B-O -( PUNCT B-O -SOFA_cv NOUN B-O -mean NOUN B-O -p NOUN B-O -= SYM B-O -0.03 NUM B-O -r NOUN B-O -= SYM B-O -0.41 NUM B-O -) PUNCT B-O -and CCONJ B-O -applied VERB B-O -ventilation NOUN B-O -pressures NOUN B-O -( PUNCT B-O -PEEP PROPN B-AC -[ X B-O -mmHg X B-O -] X B-O -p NOUN B-O -= SYM B-O -0.05 NUM B-O -r NOUN B-O -= SYM B-O -0.37 NUM B-O -) PUNCT B-O -. PUNCT B-O - -To PART B-O -do VERB B-O -so ADV B-O -we PRON B-O -apply VERB B-O -descriptive ADJ B-O -statistics NOUN B-O -and CCONJ B-O -conduct VERB B-O -logistic ADJ B-O -and CCONJ B-O -multinomial ADJ B-O -regressions NOUN B-O -using VERB B-O -data NOUN B-O -from ADP B-O -the DET B-O -Service PROPN B-LF -Provision PROPN I-LF -Assessment PROPN I-LF -( PUNCT B-O -SPA PROPN B-AC -) PUNCT B-O -of ADP B-O -the DET B-O -Demographic PROPN B-LF -and CCONJ I-LF -Health PROPN I-LF -Surveys PROPN I-LF -( PUNCT B-O -DHS PROPN B-AC -) PUNCT B-O -for ADP B-O -all DET B-O -health NOUN B-O -facilities NOUN B-O -in ADP B-O -Malawi PROPN B-O -in ADP B-O -2013/2014 NUM B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -CABG PROPN B-AC -, PUNCT B-O -coronary ADJ B-LF -artery NOUN I-LF -bypass NOUN I-LF -grift NOUN I-LF -; PUNCT B-O -PTCA PROPN B-AC -, PUNCT B-O -percutaneous ADJ B-LF -transluminal ADJ I-LF -coronary ADJ I-LF -angioplasty NOUN I-LF -; PUNCT B-O -ACE PROPN B-AC -: PUNCT B-O -Angiotensin NOUN B-LF -converting VERB I-LF -enzyme NOUN I-LF -. PUNCT B-O - -Consignments NOUN B-O -with ADP B-O -one NUM B-O -or CCONJ B-O -more ADJ B-O -“ PUNCT B-O -POS PROPN B-AC -” PUNCT B-O -samples NOUN B-O -were AUX B-O -classified VERB B-O -as ADP B-O -OJD PROPN B-AC -“ PUNCT B-O -Positive ADJ B-LF -” PUNCT B-O -. PUNCT B-O - -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -RNAi PROPN B-AC -, PUNCT B-O -RNA NOUN B-LF -interference NOUN I-LF -; PUNCT B-O -TOR PROPN B-AC -, PUNCT B-O -Target NOUN B-LF -of ADP I-LF -Rapamycin PROPN I-LF -; PUNCT B-O -tub NOUN B-O -. PUNCT B-O - -Gal4 NOUN B-O -, PUNCT B-O -tubulin NOUN B-O -. PUNCT B-O - -Gal4 NOUN B-O -; PUNCT B-O -UAS PROPN B-AC -, PUNCT B-O -Upstream PROPN B-LF -activator NOUN I-LF -sequence NOUN I-LF -; PUNCT B-O -Yki PROPN B-AC -, PUNCT B-O -Yorkie PROPN B-LF -. PUNCT B-O - -The DET B-O -Italian ADJ B-LF -Liver PROPN I-LF -Cancer PROPN I-LF -( PUNCT B-O -ITA.LI.CA PROPN B-AC -) PUNCT B-O -dataset NOUN B-O -, PUNCT B-O -including VERB B-O -more ADJ B-O -than ADP B-O -5,000 NUM B-O -Italian ADJ B-O -HCC PROPN B-AC -patients NOUN B-O -prospectively ADV B-O -enrolled VERB B-O -from ADP B-O -1 NUM B-O -January PROPN B-O -1987 NUM B-O -to ADP B-O -31 NUM B-O -March PROPN B-O -2012 NUM B-O -, PUNCT B-O -was AUX B-O -used VERB B-O -for ADP B-O -the DET B-O -training NOUN B-O -and CCONJ B-O -internal ADJ B-O -validation NOUN B-O -sets NOUN B-O -. PUNCT B-O - -Schisandra PROPN B-LF -chinensis PROPN I-LF -( PUNCT B-O -SC PROPN B-AC -) PUNCT B-O -has VERB B-O -a DET B-O -long ADJ B-O -history NOUN B-O -as ADP B-O -a DET B-O -medicinal ADJ B-O -herb NOUN B-O -and CCONJ B-O -is AUX B-O -a DET B-O -traditional ADJ B-O -component NOUN B-O -in ADP B-O -oriental ADJ B-O -medicines NOUN B-O -[ PUNCT B-O -19,20 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Astrocytes NOUN B-LF -aged VERB I-LF -seven NUM I-LF -days NOUN I-LF -( PUNCT B-O -E7 PROPN B-AC -) PUNCT B-O -showed VERB B-O -increased VERB B-O -proliferation NOUN B-O -and CCONJ B-O -diminished ADJ B-O -differentiation NOUN B-O -, PUNCT B-O -while SCONJ B-O -21 NUM B-O -- PUNCT B-O -day NOUN B-O -- PUNCT B-O -old ADJ B-O -( PUNCT B-O -E21 PROPN B-AC -) PUNCT B-O -astrocytes NOUN B-O -depicted VERB B-O -reversed VERB B-O -effects NOUN B-O -. PUNCT B-O - -ARE PROPN B-AC -, PUNCT B-O -antioxidant ADJ B-LF -response NOUN I-LF -element NOUN I-LF -; PUNCT B-O -IHC PROPN B-O -, PUNCT B-O -immunohistochemical NOUN B-O -; PUNCT B-O -MEF PROPN B-AC -, PUNCT B-O -mouse NOUN B-LF -embryonic ADJ I-LF -fibroblast NOUN I-LF -; PUNCT B-O -NRF2 PROPN B-AC -, PUNCT B-O -nuclear ADJ B-LF -factor NOUN I-LF -- PUNCT I-LF -erythroid NOUN I-LF -2 NUM I-LF -- PUNCT I-LF -like ADJ I-LF -2 NUM I-LF -; PUNCT B-O -PTCH1 PROPN B-AC -, PUNCT B-O -Patched VERB B-LF -1 NUM I-LF -Reviewer NOUN B-O -# NOUN B-O -3 NUM B-O -: PUNCT B-O -In ADP B-O -this DET B-O -randomized ADJ B-O -controlled VERB B-O -trial NOUN B-O -, PUNCT B-O -the DET B-O -Vienna PROPN B-LF -Prediction PROPN I-LF -Model PROPN I-LF -( PUNCT B-O -VPM PROPN B-AC -) PUNCT B-O -was AUX B-O -tested VERB B-O -to ADP B-O -determine VERB B-O -whether SCONJ B-O -implementing VERB B-O -the DET B-O -model NOUN B-O -would AUX B-O -reduce VERB B-O -recurrence NOUN B-O -risk NOUN B-O -. PUNCT B-O - -883 NUM B-O -patients NOUN B-O -were AUX B-O -randomised VERB B-O -to ADP B-O -using VERB B-O -the DET B-O -VPM PROPN B-AC -compared VERB B-O -with ADP B-O -usual ADJ B-O -care NOUN B-O -. PUNCT B-O - -While SCONJ B-O -various ADJ B-O -cytokines NOUN B-O -and CCONJ B-O -growth NOUN B-O -factors NOUN B-O -are AUX B-O -considered VERB B-O -to ADP B-O -contribute VERB B-O -to ADP B-O -skin NOUN B-O -fibroblast NOUN B-O -activation NOUN B-O -in ADP B-O -scleroderma NOUN B-O -, PUNCT B-O -transforming VERB B-LF -growth NOUN I-LF -factor NOUN I-LF -- PUNCT I-LF -β PUNCT I-LF -( PUNCT B-O -TGF-β PROPN B-AC -) PUNCT B-O -plays VERB B-O -an DET B-O -important ADJ B-O -role NOUN B-O -in ADP B-O -the DET B-O -fibrotic ADJ B-O -reaction NOUN B-O -of ADP B-O -scleroderma NOUN B-O -pathology NOUN B-O -[ X B-O -5 NUM B-O -, PUNCT B-O -6 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Additionally ADV B-O -, PUNCT B-O -the DET B-O -latest ADJ B-O -2020 NUM B-O -ESC PROPN B-O -Acute ADJ B-O -Coronary ADJ B-O -Syndromes PROPN B-O -( PUNCT B-O -ACS PROPN B-O -) PUNCT B-O -in ADP B-O -Patients NOUN B-O -Presenting VERB B-O -without ADP B-O -Persistent ADJ B-O -ST ADJ B-O -- PUNCT B-O -Segment PROPN B-O -Elevation PROPN B-O -( PUNCT B-O -Management NOUN B-O -of ADP B-O -) PUNCT B-O -Guidelines PROPN B-O -recommend VERB B-O -complete ADJ B-O -revascularization NOUN B-O -in ADP B-O -non ADJ B-O -- PUNCT B-O -ST ADJ B-O -- PUNCT B-O -elevation ADJ B-O -acute ADJ B-O -coronary ADJ B-O -syndrome NOUN B-O -( PUNCT B-O -NSTE PROPN B-O -- PUNCT B-O -ACS PROPN B-O -) PUNCT B-O -patients NOUN B-O -without ADP B-O -cardiogenic ADJ B-O -shock NOUN B-O -and CCONJ B-O -with ADP B-O -MV PROPN B-O -coronary ADJ B-LF -artery NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -CAD PROPN B-AC -) PUNCT B-O -but CCONJ B-O -offer VERB B-O -no DET B-O -recommendations NOUN B-O -for ADP B-O -patients NOUN B-O -with ADP B-O -severe ADJ B-O -LVSD NOUN B-O -[ PUNCT B-O -12 NUM B-O -] PUNCT B-O -. PUNCT B-O - -We PRON B-O -have AUX B-O -previously ADV B-O -described VERB B-O -the DET B-O -presence NOUN B-O -of ADP B-O -the DET B-O -complement NOUN B-O -- PUNCT B-O -regulating VERB B-O -protein NOUN B-O -salivary ADJ B-LF -scavenger NOUN I-LF -and CCONJ I-LF -agglutinin NOUN I-LF -( PUNCT B-O -SALSA PROPN B-AC -) PUNCT B-O -in ADP B-O -amniotic ADJ B-O -fluid NOUN B-O -. PUNCT B-O - -Their PRON B-O -serum NOUN B-O -samples NOUN B-O -were AUX B-O -extracted VERB B-O -from ADP B-O -a DET B-O -population NOUN B-O -- PUNCT B-O -representative ADJ B-O -biobank NOUN B-O -, PUNCT B-O -the DET B-O -Finnish PROPN B-LF -Maternity PROPN I-LF -Cohort PROPN I-LF -( PUNCT B-O -FMC PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -18,21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Previous ADJ B-O -studies NOUN B-O -of ADP B-O -ischemia NOUN B-LF -- ADJ I-LF -reperfusion NOUN I-LF -injury NOUN I-LF -( PUNCT B-O -IRI PROPN B-AC -) PUNCT B-O -in ADP B-O -hearts NOUN B-O -from ADP B-O -mice NOUN B-O -with ADP B-O -cardiac NOUN B-O -- ADJ B-O -restricted VERB B-O -overexpression NOUN B-O -of ADP B-O -CCN2 PROPN B-O -have AUX B-O -shown VERB B-O -that SCONJ B-O -CCN2 PROPN B-O -increases VERB B-O -tolerance NOUN B-O -towards ADP B-O -IRI PROPN B-AC -. PUNCT B-O - -The DET B-O -objectives NOUN B-O -of ADP B-O -this DET B-O -study NOUN B-O -were AUX B-O -to PART B-O -investigate VERB B-O -to PART B-O -what DET B-O -extent NOUN B-O -post ADJ B-O -- ADJ B-O -ischemic ADJ B-O -administration NOUN B-O -of ADP B-O -recombinant ADJ B-O -human ADJ B-O -CCN2 PROPN B-O -( PUNCT B-O -rhCCN2 PROPN B-AC -) PUNCT B-O -would AUX B-O -limit VERB B-O -infarct ADJ B-O -size NOUN B-O -and CCONJ B-O -improve VERB B-O -functional ADJ B-O -recovery NOUN B-O -and CCONJ B-O -what DET B-O -signaling NOUN B-O -pathways NOUN B-O -are AUX B-O -involved VERB B-O -. PUNCT B-O - -Type NOUN B-O -I NUM B-O -methanotrophs NOUN B-O -( PUNCT B-O -including VERB B-O -Methylococcus PROPN B-O -) PUNCT B-O -, PUNCT B-O -which PRON B-O -are AUX B-O -all PRON B-O -members NOUN B-O -of ADP B-O -the DET B-O -Gammaproteobacteria NOUN B-O -, PUNCT B-O -utilize VERB B-O -ribulose NOUN B-LF -monophosphate NOUN I-LF -( PUNCT B-O -RuMP PROPN B-AC -) PUNCT B-O -as ADP B-O -the DET B-O -primary ADJ B-O -pathway NOUN B-O -for ADP B-O -formaldehyde NOUN B-O -assimilation NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -those PRON B-O -of ADP B-O -type NOUN B-O -II NUM B-O -, PUNCT B-O -which PRON B-O -are AUX B-O -all PRON B-O -Alphaproteobacteria NOUN B-O -, PUNCT B-O -use VERB B-O -the DET B-O -serine ADJ B-O -pathway NOUN B-O -( PUNCT B-O -Hanson PROPN B-O -and CCONJ B-O -Hanson PROPN B-O -1996 NUM B-O -) PUNCT B-O -. PUNCT B-O - -For ADP B-O -SNP PROPN B-AC -validation NOUN B-O -statistics NOUN B-O -using VERB B-O -a DET B-O -Markov PROPN B-O -chain NOUN B-O -method NOUN B-O -, PUNCT B-O -the DET B-O -selected VERB B-O -SNP PROPN B-AC -markers NOUN B-O -were AUX B-O -further ADV B-O -examined VERB B-O -by ADP B-O -testing VERB B-O -the DET B-O -deviation NOUN B-O -from ADP B-O -Hardy PROPN B-LF -Weinberg PROPN I-LF -equilibrium NOUN I-LF -( PUNCT B-O -HWE PROPN B-AC -) PUNCT B-O -for ADP B-O -each DET B-O -SNP PROPN B-AC -locus NOUN B-O -( PUNCT B-O -S62 PROPN B-O -Table NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -for ADP B-O -each DET B-O -breed NOUN B-O -population NOUN B-O -( PUNCT B-O -S63 PROPN B-O -Table NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Those DET B-O -individuals NOUN B-O -who PRON B-O -participated VERB B-O -in ADP B-O -an DET B-O -external ADJ B-LF -quality NOUN I-LF -assurance NOUN I-LF -( PUNCT B-O -EQA PROPN B-AC -) PUNCT B-O -program NOUN B-O -accounted VERB B-O -for ADP B-O -36(60 NUM B-O -% NOUN B-O -) PUNCT B-O -( PUNCT B-O -Table NOUN B-O -1 NUM B-O -) PUNCT B-O -. PUNCT B-O - -However ADV B-O -, PUNCT B-O -the DET B-O -Swedish ADJ B-O -study NOUN B-O -of ADP B-O -Rai PROPN B-O -et PROPN B-O -al.[11 X B-O -] X B-O -reported VERB B-O -a DET B-O -clear ADJ B-O -increase NOUN B-O -in ADP B-O -prevalence NOUN B-O -in ADP B-O -the DET B-O -most ADV B-O -deprived ADJ B-O -backgrounds NOUN B-O -even ADV B-O -after ADP B-O -taking VERB B-O -into ADP B-O -account NOUN B-O -other ADJ B-O -associated VERB B-O -factors NOUN B-O -and CCONJ B-O -for ADP B-O -all DET B-O -cases NOUN B-O -of ADP B-O -ASD PROPN B-AC -studied VERB B-O -i.e. X B-O -with ADP B-O -or CCONJ B-O -without ADP B-O -associated VERB B-O -intellectual ADJ B-LF -disability NOUN I-LF -( PUNCT B-O -ID PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -A DET B-O -comparison NOUN B-O -of ADP B-O -comorbidities NOUN B-O -recorded VERB B-O -through ADP B-O -HES PROPN B-AC -with ADP B-O -those PRON B-O -from ADP B-O -primary ADJ B-O -care NOUN B-O -records NOUN B-O -( PUNCT B-O -clinical ADJ B-LF -practice NOUN I-LF -research NOUN I-LF -database NOUN I-LF -, PUNCT B-O -CPRD PROPN B-AC -) PUNCT B-O -found VERB B-O -that SCONJ B-O -CPRD PROPN B-AC -recorded VERB B-O -more ADJ B-O -comorbidity NOUN B-O -than ADP B-O -HES PROPN B-AC -, PUNCT B-O -but CCONJ B-O -this PRON B-O -did AUX B-O -not PART B-O -adversely ADV B-O -affect VERB B-O -their PRON B-O -models NOUN B-O -of ADP B-O -mortality NOUN B-O -risk NOUN B-O -after ADP B-O -gastrointestinal ADJ B-O -bleeding NOUN B-O -or CCONJ B-O -diabetes NOUN B-O -[ PUNCT B-O -24 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In SCONJ B-O -order NOUN B-O -to PART B-O -examine VERB B-O -whether SCONJ B-O -ID PROPN B-AC -is AUX B-O -related VERB B-O -with ADP B-O -children NOUN B-O -with ADP B-O -hypothyroidism NOUN B-O -or CCONJ B-O -with ADP B-O -low ADJ B-O -income NOUN B-O -, PUNCT B-O -multivariable ADJ B-O -analyses NOUN B-O -were AUX B-O -performed VERB B-O -using VERB B-O -Cox PROPN B-O -proportional ADJ B-O -hazards NOUN B-O -models NOUN B-O -to PART B-O -calculate VERB B-O -adjusted VERB B-O -hazard NOUN B-LF -ratios NOUN I-LF -( PUNCT B-O -HRs PROPN B-AC -) PUNCT B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -intervals NOUN I-LF -[ PUNCT B-O -CIs PROPN B-AC -] PUNCT B-O -) PUNCT B-O -as ADP B-O -an DET B-O -estimate NOUN B-O -of ADP B-O -the DET B-O -relative ADJ B-O -rate NOUN B-O -of ADP B-O -ID PROPN B-AC -. PUNCT B-O - -The DET B-O -proportionality NOUN B-O -assumption NOUN B-O -was AUX B-O -tested VERB B-O -by ADP B-O -plotting VERB B-O -Schoenfeld PROPN B-O -- PUNCT B-O -like ADJ B-O -residuals NOUN B-O -. PUNCT B-O - -This DET B-O -pathway NOUN B-O -directly ADV B-O -controls VERB B-O -the DET B-O -expression NOUN B-O -of ADP B-O -many ADJ B-O -cell NOUN B-O -- PUNCT B-O -cycle NOUN B-O -genes NOUN B-O -and CCONJ B-O -plays VERB B-O -a DET B-O -key ADJ B-O -role NOUN B-O -in ADP B-O -embryonic ADJ B-LF -stem NOUN I-LF -cell NOUN I-LF -( PUNCT B-O -ESC PROPN B-AC -) PUNCT B-O -self NOUN B-O -- PUNCT B-O -renewal NOUN B-O -[ PUNCT B-O -37–39,54,55 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -are AUX B-O -presented VERB B-O -as ADP B-O -mean ADJ B-LF -fluorescence NOUN I-LF -intensity NOUN I-LF -( PUNCT B-O -MFI PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -MFI PROPN B-AC -was AUX B-O -determined VERB B-O -by ADP B-O -FlowJo PROPN B-O -Software PROPN B-O -( PUNCT B-O -TreeStar PROPN B-O -, PUNCT B-O -Ashland PROPN B-O -, PUNCT B-O -OR PROPN B-O -, PUNCT B-O -USA PROPN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -line NOUN B-O -in ADP B-O -the DET B-O -middle NOUN B-O -represents VERB B-O -the DET B-O -median ADJ B-O -value NOUN B-O -. PUNCT B-O - -One NUM B-O -such ADJ B-O -insecticide NOUN B-O -is AUX B-O -pyriproxyfen NOUN B-LF -( PUNCT B-O -PPF PROPN B-AC -) PUNCT B-O -, PUNCT B-O -an DET B-O -insect NOUN B-O -juvenile ADJ B-O -hormone NOUN B-O -analogue NOUN B-O -that PRON B-O -kills VERB B-O -mosquito NOUN B-O -juveniles NOUN B-O -at ADP B-O -minute ADJ B-O -doses NOUN B-O -and CCONJ B-O -can AUX B-O -safely ADV B-O -be AUX B-O -used VERB B-O -even ADV B-O -in ADP B-O -drinking NOUN B-O -water NOUN B-O -[ PUNCT B-O -3,27,28 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Of ADP B-O -the DET B-O -22 NUM B-O -studies NOUN B-O -providing VERB B-O -results NOUN B-O -from ADP B-O -human ADJ B-LF -immunodeficiency NOUN I-LF -virus NOUN I-LF -( PUNCT B-O -HIV)-testing PROPN B-AC -, PUNCT B-O -12 NUM B-O -( PUNCT B-O -55 NUM B-O -% PUNCT B-O -) PUNCT B-O -reported VERB B-O -HIV PROPN B-AC -prevalence NOUN B-O -greater ADJ B-O -than ADP B-O -50%[39,40,42,43,45–49,55,59 NUM B-O -] PUNCT B-O -. PUNCT B-O - -To PART B-O -investigate VERB B-O -whether SCONJ B-O -spz5 PROPN B-O -has VERB B-O -neurotrophic ADJ B-O -function NOUN B-O -we PRON B-O -first ADV B-O -visualised VERB B-O -its PRON B-O -expression NOUN B-O -pattern NOUN B-O -. PUNCT B-O - -spz5 PROPN B-O -is AUX B-O -expressed VERB B-O -at ADP B-O -the DET B-O -embryonic ADJ B-O -CNS PROPN B-AC -midline NOUN B-O -( PUNCT B-O -Figure PROPN B-O -8C NUM B-O -) PUNCT B-O -, PUNCT B-O -in ADP B-O -muscles NOUN B-O -( PUNCT B-O -Figure PROPN B-O -9A NUM B-O -) PUNCT B-O -, PUNCT B-O -in ADP B-O -the DET B-O -epidermis NOUN B-O -( PUNCT B-O -unpublished ADJ B-O -data NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -in ADP B-O -the DET B-O -embryonic ADJ B-O -head NOUN B-O -peripheral ADJ B-LF -nervous ADJ I-LF -system NOUN I-LF -( PUNCT B-O -PNS PROPN B-AC -) PUNCT B-O -( PUNCT B-O -unpublished ADJ B-O -data NOUN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -drug NOUN B-O -was AUX B-O -applied VERB B-O -to ADP B-O -the DET B-O -skin NOUN B-O -daily ADV B-O -for ADP B-O -5 NUM B-O -days NOUN B-LF -( PUNCT B-O -5 NUM B-O -d PROPN B-AC -) PUNCT B-O -or CCONJ B-O -for ADP B-O -12 NUM B-O -days NOUN B-LF -( PUNCT B-O -1 NUM B-O -, PUNCT B-O -2 NUM B-O -, PUNCT B-O -3 NUM B-O -, PUNCT B-O -4 NUM B-O -, PUNCT B-O -5 NUM B-O -, PUNCT B-O -8 NUM B-O -, PUNCT B-O -9 NUM B-O -, PUNCT B-O -10 NUM B-O -, PUNCT B-O -11 NUM B-O -, PUNCT B-O -12th ADJ B-O -day NOUN B-LF -) PUNCT B-O -( PUNCT B-O -12d NUM B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -routing NOUN B-O -of ADP B-O -DNA NOUN B-O -through ADP B-O -the DET B-O -double ADJ B-O -hexamers NOUN B-O -is AUX B-O -unclear ADJ B-O -, PUNCT B-O -and CCONJ B-O -none NOUN B-O -of ADP B-O -the DET B-O -high ADJ B-O -- PUNCT B-O -resolution NOUN B-O -structures NOUN B-O -of ADP B-O -T-ag PROPN B-AC -to ADP B-O -date NOUN B-O -have AUX B-O -included VERB B-O -DNA NOUN B-O -. PUNCT B-O - -However ADV B-O -, PUNCT B-O -the DET B-O -recent ADJ B-O -structure NOUN B-O -of ADP B-O -the DET B-O -BPV PROPN B-AC -initiator NOUN B-O -E1 NOUN B-O -helicase NOUN B-O -domain NOUN B-O -shows VERB B-O -that SCONJ B-O -E1 NOUN B-O -forms VERB B-O -a DET B-O -hexameric ADJ B-O -ring NOUN B-O -which PRON B-O -contains VERB B-O -single ADJ B-LF -- PUNCT I-LF -stranded ADJ I-LF -DNA NOUN I-LF -( PUNCT B-O -ssDNA PROPN B-AC -) PUNCT B-O -within ADP B-O -its PRON B-O -central ADJ B-O -channel NOUN B-O -[ PUNCT B-O -20 NUM B-O -] PUNCT B-O -. PUNCT B-O - -“ PUNCT B-O -Rabbit PROPN B-O -ear NOUN B-O -” PUNCT B-O -protrusions NOUN B-O -emanating VERB B-O -from ADP B-O -the DET B-O -dodecameric ADJ B-O -T PROPN B-AC -complex NOUN B-O -have AUX B-O -been AUX B-O -observed VERB B-O -on ADP B-O -electron NOUN B-O -microscopy NOUN B-O -, PUNCT B-O -and CCONJ B-O -these DET B-O -protrusions NOUN B-O -have AUX B-O -been AUX B-O -attributed VERB B-O -to ADP B-O --agssDNA PROPN B-AC -coated VERB B-O -by ADP B-O -RPA PROPN B-AC -[ PUNCT B-O -21 NUM B-O -] PUNCT B-O -. PUNCT B-O - -We PRON B-O -tested VERB B-O -nonactivated ADJ B-O -and CCONJ B-O -PHA PROPN B-O -- PUNCT B-O -activated VERB B-O -peripheral ADJ B-LF -blood NOUN I-LF -mononuclear ADJ I-LF -cells NOUN I-LF -( PUNCT B-O -PBMCs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -as ADP B-O -well ADV B-O -as ADP B-O -purified VERB B-O -cell NOUN B-O -subsets NOUN B-O -, PUNCT B-O -including VERB B-O -CD14 NOUN B-O -+ NOUN B-O -monocytes NOUN B-O -, PUNCT B-O -activated VERB B-O -CD4 NOUN B-O -+ NOUN B-O -T NOUN B-O -cells NOUN B-O -, PUNCT B-O -immature ADJ B-O -and CCONJ B-O -mature ADJ B-O -monocyte NOUN B-O -- PUNCT B-O -derived VERB B-O -dendritic ADJ B-LF -cells NOUN I-LF -( PUNCT B-O -DCs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -LASSO PROPN B-AC -= PUNCT B-O -least ADJ B-LF -absolute ADJ I-LF -shrinkage NOUN I-LF -and CCONJ I-LF -selection NOUN I-LF -operator NOUN I-LF -. PUNCT B-O - -Parent(s)/legal NOUN B-O -authorized ADJ B-O -representatives NOUN B-O -also ADV B-O -provided VERB B-O -current ADJ B-O -inhaled VERB B-LF -corticosteroid NOUN I-LF -( PUNCT B-O -ICS PROPN B-AC -) PUNCT B-O -controller NOUN B-O -medication NOUN B-O -( PUNCT B-O -Asmanex PROPN B-O -® PUNCT B-O -, PUNCT B-O -Flovent PROPN B-O -® PUNCT B-O -, PUNCT B-O -Qvar PROPN B-O -® PUNCT B-O -, PUNCT B-O -Pulmicort PROPN B-O -® PUNCT B-O -, PUNCT B-O -Advair PROPN B-O -® PUNCT B-O -, PUNCT B-O -Dulera PROPN B-O -® PUNCT B-O -, PUNCT B-O -Symbicort PROPN B-O -® PUNCT B-O -, PUNCT B-O -etc X B-O -. PUNCT B-O - -) PUNCT B-O -. PUNCT B-O - -For ADP B-O -transmission NOUN B-LF -electron NOUN I-LF -microscopy NOUN I-LF -( PUNCT B-O -TEM PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -specimens NOUN B-O -were AUX B-O -then ADV B-O -washed VERB B-O -3×20 NUM B-O -min NOUN B-O -in ADP B-O -the DET B-O -same ADJ B-O -buffer NOUN B-O -as SCONJ B-O -used VERB B-O -for ADP B-O -fixation NOUN B-O -, PUNCT B-O -and CCONJ B-O -post VERB B-O -- VERB B-O -fixed VERB B-O -in ADP B-O -1–2 NUM B-O -% NOUN B-O -osmium NOUN B-O -tetroxide NOUN B-O -( PUNCT B-O -OsO4 NOUN B-O -) PUNCT B-O -in ADP B-O -the DET B-O -same ADJ B-O -buffer NOUN B-O -for ADP B-O -1–3 NUM B-O -h. NOUN B-O -According VERB B-O -to ADP B-O -projection NOUN B-O -of ADP B-O -Central PROPN B-LF -Statistics PROPN I-LF -Agency PROPN I-LF -( PUNCT B-O -CSA PROPN B-AC -) PUNCT B-O -of ADP B-O -Ethiopia PROPN B-O -, PUNCT B-O -in ADP B-O -the DET B-O -year NOUN B-O -2014 NUM B-O -its PRON B-O -population NOUN B-O -was AUX B-O -about ADP B-O -3.2 NUM B-O -million NUM B-O -[ PUNCT B-O -17 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -Major ADJ B-O -Adverse PROPN B-O -Cardiovascular PROPN B-O -Events PROPN B-O -calculator NOUN B-O -( PUNCT B-O -CRCRTR-MACE PROPN B-AC -) PUNCT B-O -estimates VERB B-O -the DET B-O -burden NOUN B-O -of ADP B-O -cardiovascular ADJ B-O -risk NOUN B-O -in ADP B-O -renal ADJ B-LF -transplant NOUN I-LF -recipients NOUN I-LF -( PUNCT B-O -RTR PROPN B-AC -) PUNCT B-O -. NOUN B-O -Our PRON B-O -recent ADJ B-O -study NOUN B-O -of ADP B-O -95 NUM B-O -RTR PROPN B-AC -reported VERB B-O -the DET B-O -7 NUM B-O -- PUNCT B-O -year NOUN B-O -median ADJ B-O -risk NOUN B-O -of ADP B-O -cardiovascular ADJ B-O -events NOUN B-O -( PUNCT B-O -CVE PROPN B-O -) PUNCT B-O -to ADP B-O -be AUX B-O -9.97 NUM B-O -% NOUN B-O -, PUNCT B-O -ranging VERB B-O -from ADP B-O -1.93 NUM B-O -to ADP B-O -84.27 NUM B-O -% NOUN B-O -. NOUN B-O -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -DHQ PROPN B-AC -, PUNCT B-O -Diet PROPN B-LF -History PROPN I-LF -Questionnaire PROPN I-LF -. PUNCT B-O - -The DET B-O -main ADJ B-O -outcome NOUN B-O -variable NOUN B-O -was AUX B-O -the DET B-O -nutritional ADJ B-O -status NOUN B-O -of ADP B-O -reproductive ADJ B-O -age NOUN B-O -women NOUN B-O -, PUNCT B-O -measured VERB B-O -using VERB B-O -the DET B-O -WHO PROPN B-AC -adult NOUN B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -classification NOUN B-O -[ PUNCT B-O -13 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -used VERB B-O -by ADP B-O -the DET B-O -Tanzanian PROPN B-O -National PROPN B-O -Bureau PROPN B-O -of ADP B-O -Statistics PROPN B-O -and CCONJ B-O -ICF PROPN B-AC -International PROPN B-O -[ PUNCT B-O -24 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Using VERB B-O -rat ADJ B-O -insulinoma NOUN B-O -INS-1 NOUN B-O -832/3 NUM B-O -cells NOUN B-O -engineered VERB B-O -by ADP B-O -clustered VERB B-LF -regularly ADV I-LF -interspaced VERB I-LF -short ADJ I-LF -palindromic ADJ I-LF -repeat NOUN I-LF -( PUNCT B-O -- PUNCT I-LF -CRISPR)/CRISPR PROPN B-AC -associated VERB I-LF -9 NUM I-LF -( PUNCT B-O -Cas9 PROPN B-AC -) PUNCT B-O -to PART B-O -delete VERB B-O -endogenous ADJ B-O -GLP-1R PROPN B-AC -[ X B-O -40 X B-O -] X B-O -stably ADV B-O -expressing VERB B-O -human ADJ B-O -SNAP PROPN B-O -- PUNCT B-O -GLP-1R PROPN B-AC -( PUNCT B-O -INS-1 NOUN B-O -832/3 NUM B-O -GLP-1R−/− PROPN B-AC -SNAP PROPN B-O -- PUNCT B-O -GLP-1R PROPN B-AC -cells NOUN B-O -) PUNCT B-O -, PUNCT B-O -we PRON B-O -detected VERB B-O -a DET B-O -rapid ADJ B-O -increase NOUN B-O -in ADP B-O -TR PROPN B-AC --FRET PROPN B-AC -with ADP B-O -exendin-4 NOUN B-O -, PUNCT B-O -which PRON B-O -reached VERB B-O -a DET B-O -maximum NOUN B-O -within ADP B-O -10 NUM B-O -min NOUN B-O -( PUNCT B-O -Fig NOUN B-O -1D NUM B-O -) PUNCT B-O -. PUNCT B-O - -IRR PROPN B-AC -, PUNCT B-O -incidence NOUN B-LF -rate NOUN I-LF -ratio NOUN I-LF -To PART B-O -cytologically ADV B-O -characterize VERB B-O -the DET B-O -genetic ADJ B-O -constitution NOUN B-O -of ADP B-O -5113 NUM B-O -, PUNCT B-O -root NOUN B-O -cells NOUN B-O -and CCONJ B-O -pollen NOUN B-LF -mother NOUN I-LF -cells NOUN I-LF -( PUNCT B-O -PMCs PROPN B-AC -) PUNCT B-O -were AUX B-O -used VERB B-O -( PUNCT B-O -Fig NUM B-O -1 NUM B-O -and CCONJ B-O -Table PROPN B-O -1 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Two NUM B-O -tissue NOUN B-O -- PUNCT B-O -specific ADJ B-O -DNase NOUN B-LF -l NOUN I-LF -hypersensitive ADJ I-LF -sites NOUN I-LF -( PUNCT B-O -DHS PROPN B-AC -) PUNCT B-O -in ADP B-O -this DET B-O -part NOUN B-O -of ADP B-O -the DET B-O -locus NOUN B-O -correspond VERB B-O -to ADP B-O -a DET B-O -promoter NOUN B-O -associated VERB B-O -with ADP B-O -DQ52 PROPN B-O -and CCONJ B-O -the DET B-O -intronic ADJ B-O -enhancer NOUN B-O -Eμ PROPN B-O -. PUNCT B-O - -A DET B-O -cluster NOUN B-O -of ADP B-O -three NUM B-O -DHSs PROPN B-AC -was AUX B-O -recently ADV B-O -identified VERB B-O -just ADV B-O -5′ NUM B-O -of ADP B-O -DFL16.1 NUM B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -to PART B-O -diabetes NOUN B-LF -mellitus NOUN I-LF -( PUNCT B-O -DM PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -established VERB B-O -as ADP B-O -one NUM B-O -of ADP B-O -the DET B-O -most ADV B-O -significant ADJ B-O -risk NOUN B-O -factors NOUN B-O -of ADP B-O -coronary ADJ B-LF -artery NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -CAD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -prediabetic ADJ B-O -conditions NOUN B-O -such ADJ B-O -as ADP B-O -impaired ADJ B-LF -glucose NOUN I-LF -tolerance NOUN I-LF -( PUNCT B-O -IGT PROPN B-AC -) PUNCT B-O -have AUX B-O -been AUX B-O -also ADV B-O -reported VERB B-O -to PART B-O -increase VERB B-O -the DET B-O -risk NOUN B-O -of ADP B-O -cardiovascular ADJ B-O -events NOUN B-O -and CCONJ B-O -affect VERB B-O -mortality NOUN B-O -rates NOUN B-O -[ PUNCT B-O -1 NUM B-O -, PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -GLM PROPN B-O -, PUNCT B-O -generalized ADJ B-O -linear ADJ B-O -model NOUN B-O -; PUNCT B-O -HCV PROPN B-AC -, PUNCT B-O -hepatitis NOUN B-LF -C PROPN I-LF -virus NOUN I-LF -; PUNCT B-O -HR PROPN B-AC -, PUNCT B-O -hazard NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -ITT PROPN B-AC -, PUNCT B-O -intention NOUN B-LF -- PUNCT I-LF -to PART I-LF -- PUNCT I-LF -treat VERB I-LF -; PUNCT B-O -OR PROPN B-AC -, PUNCT B-O -odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -PP NOUN B-O -, PUNCT B-O -per ADP B-O -protocol NOUN B-O -; PUNCT B-O -SAE NOUN B-O -, PUNCT B-O -severe ADJ B-O -adverse ADJ B-O -event NOUN B-O -; PUNCT B-O -SVR PROPN B-AC -, PUNCT B-O -sustained ADJ B-LF -virologic ADJ I-LF -response NOUN I-LF -. PUNCT B-O - -AC PROPN B-AC -, PUNCT B-O -adenylate NOUN B-LF -cyclase NOUN I-LF -catalytic ADJ I-LF -domain NOUN I-LF -; PUNCT B-O -CaM PROPN B-AC -, PUNCT B-O -calmodulin NOUN B-LF -. PUNCT B-O - -ASE PROPN B-AC -, PUNCT B-O -allele NOUN B-LF -- PUNCT I-LF -specific ADJ I-LF -expression NOUN I-LF -; PUNCT B-O -BDNF PROPN B-AC -, PUNCT B-O -brain NOUN B-LF -- PUNCT I-LF -derived VERB I-LF -neurotrophic ADJ I-LF -factor NOUN I-LF -; PUNCT B-O -F1 PROPN B-AC -, PUNCT B-O -first ADJ B-LF -- PUNCT I-LF -generation NOUN I-LF -; PUNCT B-O -OF PROPN B-AC -, PUNCT B-O -owl NOUN B-LF -finch NOUN I-LF -; PUNCT B-O -OZ PROPN B-AC -, PUNCT B-O -F1 PROPN B-AC -hybrid ADJ B-O -offspring NOUN B-O -between ADP B-O -OF PROPN B-AC -♀ PUNCT B-O -and CCONJ B-O -ZF PROPN B-AC -♂ PUNCT B-O -; PUNCT B-O -RA PROPN B-AC -, PUNCT B-O -robust ADJ B-LF -nucleus NOUN I-LF -of ADP I-LF -the DET I-LF -arcopallium NOUN I-LF -; PUNCT B-O -RPKM PROPN B-AC -, PUNCT B-O -reads NOUN B-LF -per ADP I-LF -kilobase NOUN I-LF -of ADP I-LF -transcript NOUN I-LF -per ADP I-LF -million NUM I-LF -reads NOUN I-LF -mapped VERB I-LF -; PUNCT B-O -ZF PROPN B-AC -, PUNCT B-O -zebra NOUN B-LF -finch NOUN I-LF -; PUNCT B-O -ZO PROPN B-AC -, PUNCT B-O -F1 PROPN B-AC -hybrid ADJ B-O -offspring NOUN B-O -between ADP B-O -ZF PROPN B-AC -♀ PUNCT B-O -and CCONJ B-O -OF PROPN B-AC -♂ PUNCT B-O -. PUNCT B-O - -Recently ADV B-O -, PUNCT B-O -data NOUN B-O -from ADP B-O -the DET B-O -British PROPN B-O -Cardiac PROPN B-O -Intervention PROPN B-O -Society PROPN B-O -( PUNCT B-O -BCIS PROPN B-O -) PUNCT B-O -PCI PROPN B-AC -database NOUN B-O -[ X B-O -9 NUM B-O -] X B-O -and CCONJ B-O -Korea PROPN B-O -Acute PROPN B-O -Myocardial PROPN B-O -Infarction PROPN B-O -Registry PROPN B-O -[ X B-O -10 NUM B-O -, PUNCT B-O -11 NUM B-O -] X B-O -showed VERB B-O -significantly ADV B-O -lower ADJ B-O -cumulative ADJ B-O -mortality NOUN B-O -rates NOUN B-O -in ADP B-O -patients NOUN B-O -who PRON B-O -underwent VERB B-O -multivessel NOUN B-O -( PUNCT B-O -MV)-PCI NOUN B-O -than ADP B-O -in ADP B-O -those PRON B-O -who PRON B-O -underwent VERB B-O -infarct NOUN B-LF -- PUNCT I-LF -related VERB I-LF -artery NOUN I-LF -( PUNCT B-O -IRA)-only PROPN B-AC -PCI PROPN B-AC -, PUNCT B-O -demonstrating VERB B-O -that SCONJ B-O -LVSD PROPN B-O -is AUX B-O -a DET B-O -strong ADJ B-O -predictor NOUN B-O -of ADP B-O -all DET B-O -- PUNCT B-O -cause NOUN B-O -mortality NOUN B-O -. PUNCT B-O - -Phosphoglycerate NOUN B-LF -kinase NOUN I-LF -( PUNCT B-O -PGK1 PROPN B-AC -) PUNCT B-O -catalyzes VERB B-O -the DET B-O -reversible ADJ B-O -phosphotransfer NOUN B-O -reaction NOUN B-O -from ADP B-O -1 NUM B-LF -, PUNCT I-LF -3 NUM I-LF -- PUNCT I-LF -bisphosphoglycerate NOUN I-LF -( PUNCT B-O -1,3-BPG PROPN B-AC -) PUNCT B-O -to PART B-O -ADP PROPN B-O -to PART B-O -form VERB B-O -3 NUM B-LF -- PUNCT I-LF -phosphoglycerate NOUN I-LF -( PUNCT B-O -3 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -ATP NOUN B-O -. PUNCT B-O - -By ADP B-O -controlling VERB B-O -ATP NOUN B-O -and CCONJ B-O --PG3 PROPN B-AC -levels NOUN B-O -, PUNCT B-O --PGPGK1 PROPN B-AC -plays VERB B-O -an DET B-O -important ADJ B-O -role NOUN B-O -in ADP B-O -coordinating VERB B-O -energy NOUN B-O -production NOUN B-O -with ADP B-O -biosynthesis NOUN B-O -and CCONJ B-O -redox NOUN B-O -balance NOUN B-O -. PUNCT B-O - -CeMM PROPN B-AC -, PUNCT B-O -C. PROPN B-O -elegans PROPN B-O -maintenance NOUN B-O -medium NOUN B-O -; PUNCT B-O -hlh-30 PROPN B-AC -, PUNCT B-O -basic ADJ B-LF -helix NOUN I-LF -– PUNCT I-LF -loop NOUN I-LF -– PUNCT I-LF -helix NOUN I-LF -transcription NOUN I-LF -factor NOUN I-LF -30 NUM I-LF -; PUNCT B-O -hlh-30(lf PROPN B-AC -) PUNCT B-O -, PUNCT B-O -loss NOUN B-O -- PUNCT B-O -of ADP B-O -- PUNCT B-O -function NOUN B-O -tm1978 PROPN B-AC -mutation NOUN B-O -hlh-30 PROPN B-AC -; PUNCT B-O -nhr-31 NOUN B-O -, PUNCT B-O -nuclear ADJ B-O -hormone NOUN B-O -receptor NOUN B-O -31 NUM B-O -; PUNCT B-O -nhr-31(oe NOUN B-O -) PUNCT B-O -, PUNCT B-O -overexpressed VERB B-O -nhr-31 NOUN B-O -; PUNCT B-O -SEM PROPN B-AC -, PUNCT B-O -standard ADJ B-LF -error NOUN I-LF -of ADP I-LF -the DET I-LF -mean NOUN I-LF -. PUNCT B-O - -Nucleotide NOUN B-LF -- NOUN I-LF -binding VERB I-LF -leucine NOUN I-LF -- NOUN I-LF -rich ADJ I-LF -repeat NOUN I-LF -receptors NOUN I-LF -( PUNCT B-O -NLRs PROPN B-AC -) PUNCT B-O -are AUX B-O -key ADJ B-O -players NOUN B-O -in ADP B-O -this DET B-O -process NOUN B-O -and CCONJ B-O -perceive VERB B-O -the DET B-O -occurrence NOUN B-O -of ADP B-O -nonself NOUN B-O -- NOUN B-O -activities NOUN B-O -or CCONJ B-O -foreign ADJ B-O -molecules NOUN B-O -. PUNCT B-O - -All DET B-O -imaging NOUN B-O -experiments NOUN B-O -with ADP B-O -the DET B-O -exception NOUN B-O -of ADP B-O -those PRON B-O -depicted VERB B-O -in ADP B-O -Fig NOUN B-O -1B–1E NUM B-O -and CCONJ B-O -Fig NOUN B-O -B NOUN B-O -in ADP B-O -S1 NOUN B-O -Fig NOUN B-O -were AUX B-O -performed VERB B-O -at ADP B-O -30 NUM B-O -° NOUN B-O -C NOUN B-O -on ADP B-O -a DET B-O -Nikon PROPN B-O -Eclipse PROPN B-O -Ti PROPN B-O -inverted ADJ B-O -microscope NOUN B-O -equipped VERB B-O -with ADP B-O -a DET B-O -motorized VERB B-O -laser NOUN B-O -total ADJ B-LF -internal ADJ I-LF -reflection NOUN I-LF -fluorescence NOUN I-LF -( PUNCT B-O -TIRF PROPN B-AC -) PUNCT B-O -illumination NOUN B-O -unit NOUN B-O -, PUNCT B-O -a DET B-O -Borealis PROPN B-O -beam NOUN B-O -conditioning NOUN B-O -unit NOUN B-O -( PUNCT B-O -Andor PROPN B-O -) PUNCT B-O -, PUNCT B-O -a DET B-O -CSU PROPN B-O -- PUNCT B-O -W1 PROPN B-O -Yokugawa PROPN B-O -spinning VERB B-O -disk NOUN B-O -( PUNCT B-O -Andor PROPN B-O -; PUNCT B-O -Belfast PROPN B-O -, PUNCT B-O -Northern PROPN B-O -Ireland PROPN B-O -) PUNCT B-O -, PUNCT B-O -a DET B-O -60X PROPN B-O -PlanApo PROPN B-O -TIRF PROPN B-AC -1.49 NUM B-O -numerical ADJ B-LF -aperture NOUN I-LF -( PUNCT B-O -NA PROPN B-AC -) PUNCT B-O -objective NOUN B-O -( PUNCT B-O -Nikon PROPN B-O -; PUNCT B-O -Toyko PROPN B-O -, PUNCT B-O -Japan PROPN B-O -) PUNCT B-O -, PUNCT B-O -an DET B-O -iXon PROPN B-O -Ultra PROPN B-O -EMCCD PROPN B-O -camera NOUN B-O -( PUNCT B-O -Andor PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -a DET B-O -laser NOUN B-O -merge NOUN B-O -module NOUN B-O -( PUNCT B-O -LMM5 PROPN B-O -, PUNCT B-O -Spectral PROPN B-O -Applied PROPN B-O -Research PROPN B-O -; PUNCT B-O -Exton PROPN B-O -, PUNCT B-O -PA PROPN B-O -) PUNCT B-O -equipped VERB B-O -with ADP B-O -405 NUM B-O -, PUNCT B-O -440 NUM B-O -, PUNCT B-O -488 NUM B-O -, PUNCT B-O -and CCONJ B-O -561 NUM B-O -- PUNCT B-O -nm NOUN B-O -laser NOUN B-O -lines NOUN B-O -. PUNCT B-O - -Four NUM B-O -irrigation NOUN B-O -systems NOUN B-O -were AUX B-O -examined VERB B-O -in ADP B-O -this DET B-O -study NOUN B-O -: PUNCT B-O -furrow NOUN B-LF -irrigation NOUN I-LF -( PUNCT B-O -FI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -micro NOUN B-LF -- NOUN I-LF -sprinkler NOUN I-LF -irrigation NOUN I-LF -( PUNCT B-O -MS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -plastic NOUN B-O -film NOUN B-O -mulching NOUN B-O -( PUNCT B-O -PF PROPN B-AC -) PUNCT B-O -and CCONJ B-O -plastic NOUN B-O -film NOUN B-O -mulching NOUN B-O -combined VERB B-O -with ADP B-O -micro NOUN B-LF -- NOUN I-LF -sprinkler NOUN I-LF -irrigation NOUN I-LF -( PUNCT B-O -PF+MS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Of ADP B-O -these PRON B-O -, PUNCT B-O -FI PROPN B-AC -is AUX B-O -the DET B-O -local ADJ B-O -irrigation NOUN B-O -method NOUN B-O -widely ADV B-O -used VERB B-O -by ADP B-O -the DET B-O -local ADJ B-O -farmers NOUN B-O -and CCONJ B-O -thus ADV B-O -we PRON B-O -treated VERB B-O -FI PROPN B-AC -as ADP B-O -the DET B-O -control NOUN B-O -. PUNCT B-O - -ADC PROPN B-AC -, PUNCT B-O -Apparent ADJ B-LF -Diffusion NOUN I-LF -Coefficient PROPN I-LF -; PUNCT B-O -IPca PROPN B-AC -, PUNCT B-O -insignificant ADJ B-LF -prostate NOUN I-LF -cancer NOUN I-LF -; PUNCT B-O -CSPca PROPN B-AC -, PUNCT B-O -clinically ADV B-LF -significant ADJ I-LF -prostate NOUN I-LF -cancer NOUN I-LF -. PUNCT B-O - -We PRON B-O -investigated VERB B-O -557 NUM B-O -women NOUN B-O -, PUNCT B-O -recruited VERB B-O -between ADP B-O -2009 NUM B-O -and CCONJ B-O -2014 NUM B-O -from ADP B-O -the DET B-O -UK PROPN B-LF -Pregnancies PROPN I-LF -Better PROPN I-LF -Eating PROPN I-LF -and CCONJ I-LF -Activity PROPN I-LF -Trial PROPN I-LF -( PUNCT B-O -UPBEAT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -randomised ADJ B-LF -controlled VERB I-LF -trial NOUN I-LF -( PUNCT B-O -RCT PROPN B-AC -) PUNCT B-O -, PUNCT B-O -of ADP B-O -a DET B-O -lifestyle NOUN B-O -intervention NOUN B-O -( PUNCT B-O -low ADJ B-O -glycaemic ADJ B-LF -index NOUN I-LF -( PUNCT B-O -GI PROPN B-AC -) PUNCT B-O -diet NOUN B-O -plus CCONJ B-O -physical ADJ B-O -activity NOUN B-O -) PUNCT B-O -in ADP B-O -pregnant ADJ B-O -women NOUN B-O -with ADP B-O -obesity NOUN B-O -( PUNCT B-O -294 NUM B-O -contol NOUN B-O -, PUNCT B-O -263 NUM B-O -intervention NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Epidemiological ADJ B-O -studies NOUN B-O -that PRON B-O -were AUX B-O -to PART B-O -be AUX B-O -included VERB B-O -in ADP B-O -the DET B-O -current ADJ B-O -meta NOUN B-O -- PUNCT B-O -analysis NOUN B-O -studies NOUN B-O -should AUX B-O -meet VERB B-O -the DET B-O -following ADJ B-O -criteria NOUN B-O -: PUNCT B-O -1 X B-O -) PUNCT B-O -was AUX B-O -a DET B-O -population- NOUN B-O -or CCONJ B-O -hospital NOUN B-O -- PUNCT B-O -based VERB B-O -, PUNCT B-O -case NOUN B-O -- PUNCT B-O -control NOUN B-O -study NOUN B-O -or CCONJ B-O -a DET B-O -prospective ADJ B-O -or CCONJ B-O -retrospective ADJ B-O -cohort NOUN B-O -study NOUN B-O -; PUNCT B-O -2 X B-O -) PUNCT B-O -provided VERB B-O -the DET B-O -coffee NOUN B-O -intake NOUN B-O -level NOUN B-O -category NOUN B-O -and CCONJ B-O -the DET B-O -corresponding ADJ B-O -relative ADJ B-LF -risk NOUN I-LF -( PUNCT B-O -RR PROPN B-AC -) PUNCT B-O -or CCONJ B-O -the DET B-O -odds NOUN B-LF -ratio NOUN I-LF -( PUNCT B-O -OR PROPN B-AC -) PUNCT B-O -estimates NOUN B-O -and CCONJ B-O -their PRON B-O -confidential ADJ B-O -intervals NOUN B-O -( PUNCT B-O -95%CIs PROPN B-AC -) PUNCT B-O -for ADP B-O -MM PROPN B-AC -; PUNCT B-O -3 X B-O -) PUNCT B-O -not PART B-O -overlapped VERB B-O -participants NOUN B-O -with ADP B-O -other ADJ B-O -included VERB B-O -studies NOUN B-O -. PUNCT B-O - -Univariate ADJ B-O -and CCONJ B-O -multivariate ADJ B-O -Cox PROPN B-O -proportion NOUN B-O -hazard NOUN B-O -regression NOUN B-O -models NOUN B-O -were AUX B-O -used VERB B-O -to PART B-O -examine VERB B-O -the DET B-O -effect NOUN B-O -of ADP B-O -HCV PROPN B-AC -infection NOUN B-O -on ADP B-O -cataract NOUN B-O -risk NOUN B-O -through ADP B-O -hazard NOUN B-LF -ratios NOUN I-LF -( PUNCT B-O -HRs PROPN B-AC -) PUNCT B-O -with ADP B-O -their PRON B-O -respective ADJ B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -intervals NOUN I-LF -( PUNCT B-O -CIs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -HI PROPN B-AC -, PUNCT B-O -haemagglutination NOUN B-LF -inhibition NOUN I-LF -; PUNCT B-O -MCMC PROPN B-AC -, PUNCT B-O -Markov PROPN B-LF -chain NOUN I-LF -Monte PROPN I-LF -Carlo PROPN I-LF -. PUNCT B-O - -Cav3 PROPN B-AC -, PUNCT B-O -Caveolin-3 PROPN B-LF -; PUNCT B-O -CM PROPN B-AC -, PUNCT B-O -cardiomyocyte NOUN B-LF -; PUNCT B-O -Ct PROPN B-AC -, PUNCT B-O -cycle NOUN B-LF -threshold NOUN I-LF -value NOUN I-LF -; PUNCT B-O -HSA PROPN B-AC -, PUNCT B-O -heat NOUN B-LF -stable ADJ I-LF -antigen NOUN I-LF -; PUNCT B-O -P PROPN B-AC -, PUNCT B-O -postnatal ADJ B-LF -day NOUN I-LF -; PUNCT B-O -qRT PROPN B-AC -, PUNCT B-O -quantitative ADJ B-LF -real ADJ I-LF -time NOUN I-LF -polymerase NOUN I-LF -chain NOUN I-LF -reaction NOUN I-LF -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -fluorescence NOUN B-LF -- PUNCT I-LF -activated VERB I-LF -cell NOUN I-LF -sorting NOUN I-LF -( PUNCT B-O -FACS PROPN B-AC -) PUNCT B-O -analysis NOUN B-O -of ADP B-O -cell NOUN B-O -cycle NOUN B-O -showed VERB B-O -that SCONJ B-O -ATX-3 PROPN B-AC -deletion NOUN B-O -resulted VERB B-O -in ADP B-O -an DET B-O -increased VERB B-O -proportion NOUN B-O -of ADP B-O -cells NOUN B-O -in ADP B-O -G2 NOUN B-O -/ SYM B-O -M NOUN B-O -phase NOUN B-O -( PUNCT B-O -Fig PROPN B-O -4F NUM B-O -) PUNCT B-O -. PUNCT B-O - -Without ADP B-O -p53 NOUN B-O -and CCONJ B-O -ATX-3 PROPN B-AC -double ADJ B-O -KO PROPN B-AC -MEF PROPN B-AC -cells NOUN B-O -in ADP B-O -hand NOUN B-O -, PUNCT B-O -we PRON B-O -examined VERB B-O -the DET B-O -p53 NOUN B-O -- PUNCT B-O -dependence NOUN B-O -of ADP B-O -this DET B-O -effect NOUN B-O -by ADP B-O -using VERB B-O -ATX-3 PROPN B-AC -stably ADV B-O -knocked VERB B-O -down ADP B-O -HCT116 NOUN B-O -p53+/+ NOUN B-O -and CCONJ B-O -HCT116 NOUN B-O -p53-/- NOUN B-O -cells NOUN B-O -. PUNCT B-O - -In ADP B-O -Latin PROPN B-LF -America PROPN I-LF -( PUNCT B-O -LA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -proportion NOUN B-O -of ADP B-O -BC PROPN B-AC -in ADP B-O -women NOUN B-O -younger ADJ B-O -than ADP B-O -45 NUM B-O -years NOUN B-O -is AUX B-O -nearly ADV B-O -twice DET B-O -the DET B-O -proportion NOUN B-O -in ADP B-O -developed VERB B-O -countries NOUN B-O -, PUNCT B-O -a DET B-O -difference NOUN B-O -that PRON B-O -is AUX B-O -only ADV B-O -partly ADV B-O -explained VERB B-O -by ADP B-O -population NOUN B-O -age NOUN B-O -structure NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -mHAI PROPN B-AC -, PUNCT B-O -modified ADJ B-LF -hepatic ADJ I-LF -activity NOUN I-LF -index NOUN I-LF -; PUNCT B-O -T2 NOUN B-O -, PUNCT B-O -T2 NOUN B-O -- PUNCT B-O -weighted VERB B-O -image NOUN B-O -; PUNCT B-O -CE PROPN B-AC -, PUNCT B-O -contrast NOUN B-O -- PUNCT B-O -enhancement NOUN B-O -; PUNCT B-O -RLE PROPN B-AC -, PUNCT B-O -relative ADJ B-LF -liver NOUN I-LF -enhancement NOUN I-LF -, PUNCT B-O -OR PROPN B-AC -, PUNCT B-O -Odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -β PUNCT B-O -, PUNCT B-O -regression NOUN B-O -coefficient NOUN B-O -; PUNCT B-O -pvp NOUN B-O -, PUNCT B-O -portal NOUN B-O -venous ADJ B-O -phase NOUN B-O -; PUNCT B-O -dp NOUN B-O -, PUNCT B-O -delayed VERB B-O -- PUNCT B-O -phase NOUN B-O -. PUNCT B-O - -Although SCONJ B-O -patients NOUN B-O -supported VERB B-O -with ADP B-O -a DET B-O -Continuous PROPN B-O -- PUNCT B-O -Flow PROPN B-O -Left PROPN B-LF -Ventricular PROPN I-LF -Assist PROPN I-LF -Device PROPN I-LF -( PUNCT B-O -CF-LVAD PROPN B-AC -) PUNCT B-O -are AUX B-O -hemodynamically ADV B-O -stable ADJ B-O -, PUNCT B-O -their PRON B-O -exercise NOUN B-O -capacity NOUN B-O -is AUX B-O -limited ADJ B-O -. PUNCT B-O - -MAD PROPN B-AC -: PUNCT B-O -median ADJ B-LF -absolute ADJ I-LF -deviation NOUN I-LF -, PUNCT B-O -NOTFront PROPN B-AC -: PUNCT B-O -percentage NOUN B-O -of ADP B-O -misclassified VERB B-O -DMUs PROPN B-AC -, PUNCT B-O -PU20 NUM B-O -% NOUN B-O -: PUNCT B-O -percentage NOUN B-O -of ADP B-O -underestimation NOUN B-O -, PUNCT B-O -PO20 NUM B-O -% NOUN B-O -: PUNCT B-O -percentage NOUN B-O -of ADP B-O -overestimation NOUN B-O -, PUNCT B-O -rs NOUN B-O -: PUNCT B-O -Spearman PROPN B-O -’s PART B-O -rank NOUN B-O -correlation NOUN B-O -. PUNCT B-O - -CLANS PROPN B-AC -, PUNCT B-O -cluster NOUN B-LF -analysis NOUN I-LF -of ADP I-LF -sequences NOUN I-LF -; PUNCT B-O -MPP PROPN B-AC -, PUNCT B-O -mitochondrial ADJ B-O -processing NOUN B-O -peptide NOUN B-O -; PUNCT B-O -PreP PROPN B-AC -, PUNCT B-O -presequence NOUN B-LF -protease NOUN I-LF -; PUNCT B-O -SPP PROPN B-AC -, PUNCT B-O -stromal NOUN B-LF -processing NOUN I-LF -peptidase NOUN I-LF -. PUNCT B-O - -Washed VERB B-O -rod NOUN B-O -outer ADJ B-O -segment NOUN B-O -membranes NOUN B-O -prepared VERB B-O -from ADP B-O -fresh ADJ B-O -bovine ADJ B-O -retinas NOUN B-O -[ X B-O -36 X B-O -] PUNCT B-O -and CCONJ B-O -cell NOUN B-O -membranes NOUN B-O -of ADP B-O -TE671 PROPN B-O -cells NOUN B-O -infected VERB B-O -with ADP B-O -either CCONJ B-O -EF1α NOUN B-O -- PUNCT B-O -GC1 PROPN B-AC -- PUNCT B-O -IRES PROPN B-AC -- PUNCT B-O -eGFP NOUN B-O -or CCONJ B-O -EF1α NOUN B-O -- PUNCT B-O -eGFP NOUN B-O -virus NOUN B-O -were AUX B-O -reconstituted VERB B-O -with ADP B-O -recombinant ADJ B-O -guanylate NOUN B-LF -cyclase NOUN I-LF -activating VERB I-LF -protein–1 NOUN I-LF -( PUNCT B-O -GCAP1 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -assayed VERB B-O -for ADP B-O -GC1 PROPN B-AC -activity NOUN B-O -as SCONJ B-O -previously ADV B-O -described VERB B-O -[ X B-O -37 X B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -Multiple PROPN B-LF -Sclerosis PROPN I-LF -Impact PROPN I-LF -Scale–29 PROPN I-LF -( PUNCT B-O -MSIS-29 PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -PRO PROPN B-AC -that PRON B-O -attempts VERB B-O -to PART B-O -assess VERB B-O -both CCONJ B-O -physical ADJ B-O -and CCONJ B-O -psychological ADJ B-O -quality NOUN B-O -of ADP B-O -life NOUN B-O -in ADP B-O -multiple ADJ B-LF -sclerosis NOUN I-LF -( PUNCT B-O -MS PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -14 NUM B-O -] PUNCT B-O -. PUNCT B-O - -By ADP B-O -comparing VERB B-O -the DET B-O -gene NOUN B-O -expression NOUN B-O -ratio NOUN B-O -between ADP B-O -the DET B-O -two NUM B-O -species NOUN B-O -and CCONJ B-O -the DET B-O -allele NOUN B-LF -- ADJ I-LF -specific ADJ I-LF -expression NOUN I-LF -( PUNCT B-O -ASE PROPN B-AC -) PUNCT B-O -ratio NOUN B-O -in ADP B-O -the DET B-O -F1 PROPN B-AC -hybrids NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1D NUM B-O -) PUNCT B-O -, PUNCT B-O -we PRON B-O -assessed VERB B-O -the DET B-O -total ADJ B-O -number NOUN B-O -of ADP B-O -genes NOUN B-O -whose DET B-O -expression NOUN B-O -differs VERB B-O -by ADP B-O -divergence NOUN B-O -in ADP B-O -cis- ADJ B-O -versus ADP B-O -trans ADJ B-O -- ADJ B-O -transcriptional ADJ B-O -regulation NOUN B-O -between ADP B-O -the DET B-O -two NUM B-O -species NOUN B-O -. PUNCT B-O - -Ins PROPN B-O -= PUNCT B-O -inositol NOUN B-O -peak NOUN B-O -, PUNCT B-O -Cho PROPN B-AC -= PUNCT B-O -choline NOUN B-LF -peak NOUN B-O -, PUNCT B-O -Cr PROPN B-AC -= PUNCT B-O -creatine NOUN B-LF -/ SYM I-LF -phosphocreatine NOUN I-LF -peak NOUN B-O -, PUNCT B-O -Glx PROPN B-AC -= PUNCT B-O -glutamate NOUN B-O -/ SYM B-O -glutamine NOUN B-O -peaks NOUN B-O -, PUNCT B-O -NAA PROPN B-AC -= PUNCT B-O -N NOUN B-O -- PUNCT B-O -acetyl NOUN B-O -- PUNCT B-O -aspartate NOUN B-O -peak NOUN B-O -. PUNCT B-O - -In ADP B-O -model NOUN B-O -A NOUN B-O -, PUNCT B-O -participants NOUN B-O -< ADP B-O -30 NUM B-O -years NOUN B-O -old ADJ B-O -were AUX B-O -more ADV B-O -likely ADJ B-O -to PART B-O -have VERB B-O -good ADJ B-O -SRH PROPN B-AC -( PUNCT B-O -Odds NOUN B-LF -Ratio NOUN I-LF -( PUNCT B-O -OR PROPN B-AC -) PUNCT B-O -= SYM B-O -2.022 NUM B-O -) PUNCT B-O -than ADP B-O -participants NOUN B-O -> ADP B-O -50 NUM B-O -. PUNCT B-O - -AbSensitivity PROPN B-O -( PUNCT B-O -Antibiotic ADJ B-O -sensitivity NOUN B-O -) PUNCT B-O -, PUNCT B-O -Ca PROPN B-AC -- PUNCT B-O -Solub PROPN B-O -( PUNCT B-O -Calcium NOUN B-LF -solubilization NOUN B-O -) PUNCT B-O -, PUNCT B-O -Zn PROPN B-AC -- PUNCT B-O -Solub PROPN B-O -( PUNCT B-O -Zinc NOUN B-LF -solubilization NOUN B-O -) PUNCT B-O -, PUNCT B-O -K PROPN B-AC -- PUNCT B-O -Solub PROPN B-O -( PUNCT B-O -potassium NOUN B-LF -solubilization NOUN B-O -) PUNCT B-O -, PUNCT B-O -Mg PROPN B-AC -- PUNCT B-O -Solub PROPN B-O -( PUNCT B-O -magnesium NOUN B-LF -solubilization NOUN B-O -) PUNCT B-O -, PUNCT B-O -P PROPN B-AC -- PUNCT B-O -Solub PROPN B-O -( PUNCT B-O -phosphorus NOUN B-LF -solubilization NOUN B-O -) PUNCT B-O -. PUNCT B-O - -During ADP B-O -the DET B-O -consultation NOUN B-O -, PUNCT B-O -clinical ADJ B-O -signs NOUN B-O -of ADP B-O -a DET B-O -relevant ADJ B-O -focused ADJ B-O -examination NOUN B-O -were AUX B-O -also ADV B-O -recorded VERB B-O -( PUNCT B-O -vital ADJ B-O -and CCONJ B-O -danger NOUN B-O -signs NOUN B-O -, PUNCT B-O -temperature NOUN B-O -, PUNCT B-O -respiratory ADJ B-O -rate NOUN B-O -, PUNCT B-O -malnutrition NOUN B-O -assessment NOUN B-O -, PUNCT B-O -etc X B-O -. PUNCT B-O - -) PUNCT B-O -along ADP B-O -with ADP B-O -laboratory NOUN B-O -tests NOUN B-O -recommended VERB B-O -by ADP B-O -the DET B-O -app NOUN B-O -( PUNCT B-O -mRDT PROPN B-AC -, PUNCT B-O -C NOUN B-LF -- PUNCT I-LF -reactive ADJ I-LF -protein NOUN I-LF -[ PUNCT B-O -CRP PROPN B-AC -] PUNCT B-O -, PUNCT B-O -hemoglobin NOUN B-O -, PUNCT B-O -urinary ADJ B-O -dipstick NOUN B-O -, PUNCT B-O -etc X B-O -. PUNCT B-O - -) PUNCT B-O -. PUNCT B-O - -Pre NOUN B-LF -- PUNCT I-LF -eclampsia NOUN I-LF -( PUNCT B-O -PE PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -common ADJ B-O -pregnancy NOUN B-O -- PUNCT B-O -related VERB B-O -complication NOUN B-O -affecting VERB B-O -3 NUM B-O -% NOUN B-O -of ADP B-O -all DET B-O -pregnancies NOUN B-O -. PUNCT B-O - -Other ADJ B-O -liver NOUN B-O -reserve NOUN B-O -markers NOUN B-O -, PUNCT B-O -fibrosis NOUN B-LF -index NOUN I-LF -based VERB I-LF -on ADP I-LF -4 NUM I-LF -factors NOUN I-LF -( PUNCT B-O -FIB-4 PROPN B-AC -) PUNCT B-O -and CCONJ B-O -aspartate NOUN B-LF -aminotransferase NOUN I-LF -- PUNCT I-LF -to PART I-LF -- PUNCT I-LF -platelet NOUN I-LF -ratio NOUN I-LF -( PUNCT B-O -APRI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -have AUX B-O -also ADV B-O -been AUX B-O -proposed VERB B-O -to PART B-O -assess VERB B-O -liver NOUN B-O -dysfunction NOUN B-O -[ PUNCT B-O -16 NUM B-O -, PUNCT B-O -17 NUM B-O -] PUNCT B-O -. PUNCT B-O - -District NOUN B-O -and CCONJ B-O -health NOUN B-O -centre NOUN B-O -heads NOUN B-O -, PUNCT B-O -neglected VERB B-O -tropical ADJ B-O -diseases NOUN B-O -( PUNCT B-O -NTD NOUN B-O -) PUNCT B-O -focal ADJ B-O -persons NOUN B-O -and CCONJ B-O -integrated VERB B-LF -eye NOUN I-LF -care NOUN I-LF -workers NOUN I-LF -( PUNCT B-O -IECWs PROPN B-AC -) PUNCT B-O -were AUX B-O -involved VERB B-O -in ADP B-O -the DET B-O -key ADJ B-O -informant NOUN B-O -in ADP B-O -- PUNCT B-O -depth NOUN B-O -interview NOUN B-O -. PUNCT B-O - -ART PROPN B-AC -, PUNCT B-O -artemisinin PROPN B-LF -; PUNCT B-O -IC50 PROPN B-AC -, PUNCT B-O -concentration NOUN B-O -of ADP B-O -half ADJ B-O -- PUNCT B-O -maximal ADJ B-O -inhibition NOUN B-O -. PUNCT B-O - -n NOUN B-O -= VERB B-O -number NOUN B-O -of ADP B-O -cases NOUN B-O -; PUNCT B-O -OR PROPN B-AC -= VERB B-O -odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -CI PROPN B-AC -= VERB B-O -confidence NOUN B-LF -interval NOUN I-LF -; PUNCT B-O -IQR PROPN B-AC -= VERB B-O -interquartile ADJ B-LF -range NOUN I-LF -; PUNCT B-O -HIV PROPN B-AC -= VERB B-O -human ADJ B-LF -immunodeficiency NOUN I-LF -virus NOUN I-LF -; PUNCT B-O -TB PROPN B-AC -= VERB B-O -tuberculosis NOUN B-LF -; PUNCT B-O -pre PROPN B-AC -= VERB B-O -resistance NOUN B-O -to ADP B-O -one NUM B-O -or CCONJ B-O -more ADJ B-O -second ADJ B-O -- PUNCT B-O -line NOUN B-O -injectable ADJ B-O -drugs NOUN B-O -; PUNCT B-O --XDRSLID-TBpre PROPN B-AC -= VERB B-O -resistance NOUN B-O -to ADP B-O -one NUM B-O -or CCONJ B-O -more ADJ B-O -fluoroquinolones NOUN B-O -. PUNCT B-O - -SMC PROPN B-AC -, PUNCT B-O -seasonal ADJ B-LF -malaria NOUN I-LF -chemoprevention NOUN I-LF -. PUNCT B-O - -In ADP B-O -the DET B-O -present ADJ B-O -experimental ADJ B-O -setting NOUN B-O -, PUNCT B-O -adult ADJ B-O -male ADJ B-O -C57BL PROPN B-O -/ SYM B-O -N6 NUM B-O -mice NOUN B-O -were AUX B-O -either CCONJ B-O -flown VERB B-O -aboard ADV B-O -the DET B-O -BION PROPN B-O -- PUNCT B-O -M1 PROPN B-O -biosatellite NOUN B-O -for ADP B-O -30 NUM B-O -days NOUN B-O -on ADP B-O -orbit NOUN B-O -( PUNCT B-O -BION PROPN B-O -- PUNCT B-O -flown VERB B-O -= PUNCT B-O -BF PROPN B-AC -) PUNCT B-O -or CCONJ B-O -housed VERB B-O -as SCONJ B-O -sex- NOUN B-O -and CCONJ B-O -age NOUN B-O -- PUNCT B-O -matched VERB B-O -cohorts NOUN B-O -( PUNCT B-O -n NOUN B-O -= PUNCT B-O -5 NUM B-O -each PRON B-O -) PUNCT B-O -in ADP B-O -a DET B-O -replicate ADJ B-O -flight NOUN B-O -habitat NOUN B-O -on ADP B-O -Earth PROPN B-O -( PUNCT B-O -BION PROPN B-O -- PUNCT B-O -ground NOUN B-O -= PUNCT B-O -BG PROPN B-AC -) PUNCT B-O -as SCONJ B-O -reference NOUN B-O -flight NOUN B-LF -control NOUN I-LF -, PUNCT B-O -and CCONJ B-O -in ADP B-O -standard ADJ B-O -animal NOUN B-O -cages NOUN B-O -concomitant ADJ B-O -to ADP B-O -the DET B-O -duration NOUN B-O -of ADP B-O -the DET B-O -biosatellite NOUN B-O -flight NOUN B-O -( PUNCT B-O -flight NOUN B-LF -control NOUN I-LF -= PUNCT B-O -FC PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Mice NOUN B-O -flown VERB B-O -aboard ADV B-O -of ADP B-O -the DET B-O -biosatellite NOUN B-O -were AUX B-O -in ADP B-O -good ADJ B-O -condition NOUN B-O -after ADP B-O -landing NOUN B-O -, PUNCT B-O -as SCONJ B-O -previously ADV B-O -reported VERB B-O -by ADP B-O -Andreev PROPN B-O -- PUNCT B-O -Andrievskiy PROPN B-O -[ PUNCT B-O -17 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -this DET B-O -study NOUN B-O -, PUNCT B-O -we PRON B-O -sought VERB B-O -to PART B-O -test VERB B-O -whether SCONJ B-O -elevated ADJ B-O -levels NOUN B-O -of ADP B-O -Arc PROPN B-O -interfere VERB B-O -with ADP B-O -brain NOUN B-LF -- PUNCT I-LF -derived VERB I-LF -neurotrophic ADJ I-LF -factor NOUN I-LF -( PUNCT B-O -BDNF PROPN B-AC -) PUNCT B-O -TrkB PROPN B-O -receptor NOUN B-O -signaling NOUN B-O -, PUNCT B-O -which PRON B-O -is AUX B-O -known VERB B-O -to PART B-O -be AUX B-O -essential ADJ B-O -for ADP B-O -both CCONJ B-O -the DET B-O -induction NOUN B-O -and CCONJ B-O -maintenance NOUN B-O -of ADP B-O -LTP PROPN B-AC -. PUNCT B-O - -We PRON B-O -report VERB B-O -that SCONJ B-O -TrkB PROPN B-O -signaling NOUN B-O -in ADP B-O -the DET B-O -AS PROPN B-AC -mouse NOUN B-O -is AUX B-O -defective ADJ B-O -, PUNCT B-O -and CCONJ B-O -show VERB B-O -that SCONJ B-O -reduction NOUN B-O -of ADP B-O -Arc PROPN B-O -expression NOUN B-O -to PART B-O -control VERB B-O -levels NOUN B-O -rescues VERB B-O -the DET B-O -signaling NOUN B-O -deficits NOUN B-O -. PUNCT B-O - -One NUM B-O -key NOUN B-O -molecule NOUN B-O -in ADP B-O -this DET B-O -process NOUN B-O -is AUX B-O -an DET B-O -enzyme NOUN B-O -named VERB B-O -D NOUN B-LF -- NOUN I-LF -aminoacyl NOUN I-LF -- NOUN I-LF -tRNA NOUN I-LF -deacylase NOUN I-LF -( PUNCT B-O -DTD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -hydrolyses VERB B-O -D NOUN B-O -- NOUN B-O -amino NOUN B-O -acids NOUN B-O -attached VERB B-O -to ADP B-O -tRNA NOUN B-O -molecules NOUN B-O -( PUNCT B-O -a DET B-O -D NOUN B-O -- NOUN B-O -aminoacyl NOUN B-O -- NOUN B-O -tRNA NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Here ADV B-O -, PUNCT B-O -we PRON B-O -show VERB B-O -that SCONJ B-O -besides SCONJ B-O -acting VERB B-O -on ADP B-O -D NOUN B-O -- NOUN B-O -aminoacyl NOUN B-O -- NOUN B-O -tRNA NOUN B-O -, PUNCT B-O -DTD PROPN B-AC -also ADV B-O -efficiently ADV B-O -hydrolyses VERB B-O -the DET B-O -achiral ADJ B-O -glycine NOUN B-O -attached VERB B-O -to ADP B-O -tRNA NOUN B-O -— PUNCT B-O -glycyl NOUN B-O -- NOUN B-O -tRNA(Gly)—as NOUN B-O -DTD PROPN B-AC -’s PART B-O -active ADJ B-O -site NOUN B-O -pocket NOUN B-O -can AUX B-O -not PART B-O -discriminate VERB B-O -between ADP B-O -D NOUN B-O -- NOUN B-O -amino NOUN B-O -acids NOUN B-O -and CCONJ B-O -glycine NOUN B-O -. PUNCT B-O - -SVR PROPN B-AC -response NOUN B-O -rates NOUN B-O -were AUX B-O -calculated VERB B-O -using VERB B-O -relative ADJ B-LF -risk NOUN I-LF -( PUNCT B-O -RR PROPN B-AC -) PUNCT B-O -differences NOUN B-O -using VERB B-O -chi NOUN B-O -- PUNCT B-O -square ADJ B-O -test NOUN B-O -. PUNCT B-O - -The DET B-O -São PROPN B-LF -Paulo PROPN I-LF -Autopsy PROPN I-LF -Service PROPN I-LF -( PUNCT B-O -SPAS PROPN B-AC -) PUNCT B-O -is AUX B-O -the DET B-O -only ADJ B-O -morgue NOUN B-O -serving VERB B-O -the DET B-O -metropolitan ADJ B-O -area NOUN B-O -of ADP B-O -São PROPN B-O -Paulo PROPN B-O -( PUNCT B-O -Brazil PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Consistent ADJ B-O -with ADP B-O -our PRON B-O -hypothesis NOUN B-O -, PUNCT B-O -we PRON B-O -found VERB B-O -that SCONJ B-O -a DET B-O -strong ADJ B-O -phospho NOUN B-O -- PUNCT B-O -Rb PROPN B-AC -S249 PROPN B-O -staining NOUN B-O -positively ADV B-O -correlated VERB B-O -with ADP B-O -tumor NOUN B-O -grade NOUN B-O -exclusively ADV B-O -in ADP B-O -squamous ADJ B-LF -cell NOUN I-LF -carcinomas NOUN I-LF -( PUNCT B-O -SCC PROPN B-AC -) PUNCT B-O -and CCONJ B-O -not PART B-O -in ADP B-O -adenocarcinomas NOUN B-LF -( PUNCT B-O -AC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -meaning VERB B-O -that SCONJ B-O -most ADJ B-O -of ADP B-O -the DET B-O -SCC PROPN B-AC -tumors NOUN B-O -with ADP B-O -higher ADJ B-O -grades NOUN B-O -also ADV B-O -had VERB B-O -high ADJ B-O -scores NOUN B-O -for ADP B-O -phospho NOUN B-O -- PUNCT B-O -Rb PROPN B-AC -S249 PROPN B-O -positive ADJ B-O -cells NOUN B-O -. PUNCT B-O - -An DET B-O -observation NOUN B-O -that PRON B-O -seems VERB B-O -to PART B-O -be AUX B-O -at ADP B-O -odds NOUN B-O -with ADP B-O -the DET B-O -findings NOUN B-O -from ADP B-O -these DET B-O -ex X B-O -vivo X B-O -studies NOUN B-O -is AUX B-O -that PRON B-O -the DET B-O -eyeblink NOUN B-O -conditioned VERB B-LF -response NOUN I-LF -( PUNCT B-O -CR PROPN B-AC -) PUNCT B-O -is AUX B-O -well ADV B-O -- PUNCT B-O -predicted VERB B-O -by ADP B-O -a DET B-O -suppression NOUN B-O -in ADP B-O -Purkinje PROPN B-O -cell NOUN B-O -simple ADJ B-O -spike NOUN B-O -firing NOUN B-O -that PRON B-O -may AUX B-O -last VERB B-O -for ADP B-O -several ADJ B-O -hundreds NOUN B-O -of ADP B-O -milliseconds NOUN B-O -[ X B-O -28–31 NUM B-O -] PUNCT B-O -. PUNCT B-O - -While SCONJ B-O -PQ PROPN B-AC -is AUX B-O -tolerated VERB B-O -in ADP B-O -most ADJ B-O -patients NOUN B-O -, PUNCT B-O -it PRON B-O -can AUX B-O -cause VERB B-O -haemolysis NOUN B-O -in ADP B-O -patients NOUN B-O -with ADP B-O -glucose-6 NOUN B-LF -- PUNCT I-LF -phosphate NOUN I-LF -dehydrogenase NOUN I-LF -deficiency NOUN I-LF -( PUNCT B-O -G6PDd PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -severity NOUN B-O -of ADP B-O -which PRON B-O -is AUX B-O -dependent ADJ B-O -on ADP B-O -the DET B-O -underlying VERB B-O -genetic ADJ B-O -variant NOUN B-O -, PUNCT B-O -the DET B-O -dose NOUN B-O -of ADP B-O -PQ PROPN B-AC -administered VERB B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -age NOUN B-O -of ADP B-O -the DET B-O -patient NOUN B-O -’s PART B-O -red ADJ B-LF -blood NOUN I-LF -cell NOUN I-LF -( PUNCT B-O -RBC PROPN B-AC -) PUNCT B-O -population NOUN B-O -[ X B-O -7,8 NUM B-O -] PUNCT B-O -. PUNCT B-O - -BAC PROPN B-AC -, PUNCT B-O -bacterial ADJ B-LF -artificial ADJ I-LF -chromosome NOUN I-LF -; PUNCT B-O -CENP PROPN B-AC -, PUNCT B-O -centromere NOUN B-LF -protein NOUN I-LF -A NOUN I-LF -; PUNCT B-O --ACenX PROPN B-AC -, PUNCT B-O -X NOUN B-LF -centromere NOUN I-LF -; PUNCT B-O -ChIP PROPN B-AC -, PUNCT B-O -chromatin NOUN B-LF -immunoprecipitation NOUN I-LF -sequencing NOUN B-O -; PUNCT B-O --seqCRM PROPN B-AC -, PUNCT B-O -centromeric ADJ B-LF -retrotransposons NOUN I-LF -of ADP I-LF -maize NOUN I-LF -; PUNCT B-O -CRR PROPN B-AC -, PUNCT B-O -centromeric ADJ B-LF -retrotransposons NOUN I-LF -of ADP I-LF -rice NOUN I-LF -; PUNCT B-O -CRW PROPN B-AC -, PUNCT B-O -centromeric ADJ B-LF -retrotransposons NOUN I-LF -of ADP I-LF -wheat NOUN I-LF -; PUNCT B-O -FISH PROPN B-AC -, PUNCT B-O -fluorescence NOUN B-LF -in ADP I-LF -situ NOUN I-LF -hybridization NOUN I-LF -; PUNCT B-O -LAVA PROPN B-AC -, PUNCT B-O -LINE PROPN B-LF -- PUNCT I-LF -LINE PROPN B-AC -Alu PROPN I-LF -- PUNCT I-LF -VNTR PROPN I-LF -- PUNCT I-LF -Alu PROPN I-LF -- PUNCT I-LF -like ADJ I-LF -; PUNCT B-O -LINE PROPN B-AC -, PUNCT B-O -long ADJ B-LF -interspersed VERB I-LF -nuclear ADJ I-LF -element NOUN I-LF -; PUNCT B-O -LTR PROPN B-AC -, PUNCT B-O -long ADJ B-LF -terminal ADJ I-LF -repeat NOUN I-LF -; PUNCT B-O -Mya PROPN B-O -, PUNCT B-O -million NUM B-O -years NOUN B-O -ago ADV B-O -. PUNCT B-O - -Recently ADV B-O -, PUNCT B-O -we PRON B-O -developed VERB B-O -a DET B-O -novel ADJ B-O -and CCONJ B-O -sensitive ADJ B-O -XOR PROPN B-AC -assay NOUN B-O -for ADP B-O -the DET B-O -measurement NOUN B-O -of ADP B-O -human ADJ B-O -plasma NOUN B-O -XOR PROPN B-AC -activity NOUN B-O -that PRON B-O -is AUX B-O -based VERB B-O -on ADP B-O -[ X B-O -13C2,15N2]xanthine NOUN B-O -coupled VERB B-O -with ADP B-O -liquid NOUN B-LF -chromatography NOUN I-LF -( PUNCT B-O -mass NOUN I-LF -LC)/triplequadrupole PROPN B-AC -spectrometry NOUN I-LF -( PUNCT B-O -TQMS PROPN B-AC -) PUNCT B-O -[ X B-O -18,19 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Cadherins NOUN B-O -form VERB B-O -an DET B-O -adhesive ADJ B-O -interface NOUN B-O -all ADV B-O -along ADP B-O -the DET B-O -lateral ADJ B-O -domain NOUN B-O -but CCONJ B-O -are AUX B-O -also ADV B-O -organised VERB B-O -into ADP B-O -special ADJ B-O -complexes NOUN B-O -known VERB B-O -as ADP B-O -zonula NOUN B-LF -adherens NOUN I-LF -( PUNCT B-O -ZA PROPN B-AC -) PUNCT B-O -that PRON B-O -are AUX B-O -localised VERB B-O -at ADP B-O -the DET B-O -apical ADJ B-O -end NOUN B-O -. PUNCT B-O - -At ADP B-O -baseline NOUN B-O -, PUNCT B-O -mothers NOUN B-O -had VERB B-O -weight NOUN B-O -, PUNCT B-O -mid ADJ B-LF -- ADJ I-LF -upper ADJ I-LF -arm NOUN I-LF -circumference NOUN I-LF -( PUNCT B-O -MUAC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -hemoglobin NOUN B-O -( PUNCT B-O -Hemocue PROPN B-O -, PUNCT B-O -Ängelholm PROPN B-O -, PUNCT B-O -Sweden PROPN B-O -) PUNCT B-O -measured VERB B-O -, PUNCT B-O -and CCONJ B-O -were AUX B-O -tested VERB B-O -for ADP B-O -HIV PROPN B-O -using VERB B-O -a DET B-O -rapid ADJ B-O -test NOUN B-O -algorithm NOUN B-O -. PUNCT B-O - -Disease PROPN B-O -activity NOUN B-O -reflected VERB B-O -the DET B-O -direct ADJ B-O -results NOUN B-O -of ADP B-O -treatment NOUN B-O -, PUNCT B-O -as SCONJ B-O -measured VERB B-O -with ADP B-O -the DET B-O -Disease PROPN B-LF -Activity PROPN I-LF -Score–28 NUM I-LF -with ADP I-LF -erythrocyte NOUN I-LF -sedimentation NOUN I-LF -rate NOUN I-LF -( PUNCT B-O -DAS28-ESR PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -33 NUM B-O -] PUNCT B-O -. PUNCT B-O - -AUC PROPN B-AC -, PUNCT B-O -area NOUN B-LF -under ADP I-LF -the DET I-LF -curve NOUN I-LF -; PUNCT B-O -CITL PROPN B-O -, PUNCT B-O -calibration NOUN B-O -in ADP B-O -the DET B-O -large ADJ B-O -; PUNCT B-O -E NOUN B-O -:O NOUN B-O -, PUNCT B-O -ratio NOUN B-O -of ADP B-O -expected VERB B-O -( PUNCT B-O -predicted VERB B-O -) PUNCT B-O -probability NOUN B-O -vs ADP B-O -observed ADJ B-O -frequency NOUN B-O -of ADP B-O -the DET B-O -outcome NOUN B-O -; PUNCT B-O -STm PROPN B-AC -, PUNCT B-O -symptoms NOUN B-LF -and CCONJ I-LF -tests NOUN I-LF -model NOUN I-LF -; PUNCT B-O -Tm PROPN B-AC -, PUNCT B-O -tests NOUN B-LF -- PUNCT I-LF -only ADV I-LF -model NOUN I-LF -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -GPi PROPN B-AC -, PUNCT B-O -globus NOUN B-LF -pallidus X I-LF -- PUNCT I-LF -internus X I-LF -; PUNCT B-O -max NOUN B-O -, PUNCT B-O -maximum NOUN B-O -; PUNCT B-O -min NOUN B-O -, PUNCT B-O -minimum NOUN B-O -; PUNCT B-O -Mvt PROPN B-O -, PUNCT B-O -movement NOUN B-O -; PUNCT B-O -NHP PROPN B-AC -, PUNCT B-O -nonhuman ADJ B-LF -primate NOUN I-LF -; PUNCT B-O -sp NOUN B-O -, PUNCT B-O -spikes NOUN B-O -; PUNCT B-O -VLa PROPN B-AC -, PUNCT B-O -ventrolateral ADJ B-LF -anterior ADJ I-LF -nucleus NOUN I-LF -Recently ADV B-O -, PUNCT B-O -it PRON B-O -was AUX B-O -reported VERB B-O -that SCONJ B-O -5 NUM B-LF -- PUNCT I-LF -HT2 NOUN I-LF -receptors NOUN I-LF -( PUNCT B-O -5-HT2Rs PROPN B-AC -) PUNCT B-O -were AUX B-O -expressed VERB B-O -in ADP B-O -cartilage NOUN B-O -tissues NOUN B-O -lacking VERB B-O -both CCONJ B-O -vessels NOUN B-O -and CCONJ B-O -neurons NOUN B-O -, PUNCT B-O -suggesting VERB B-O -possible ADJ B-O -novel ADJ B-O -functions NOUN B-O -of ADP B-O -5-HT PROPN B-AC -during ADP B-O -cartilage NOUN B-O -development NOUN B-O -and CCONJ B-O -regeneration NOUN B-O -. PUNCT B-O - -MOI PROPN B-AC -, PUNCT B-O -multiplicity NOUN B-LF -of ADP I-LF -infection NOUN I-LF -. PUNCT B-O - -Changes NOUN B-O -in ADP B-O -anthropometric ADJ B-O -indices NOUN B-O -[ PUNCT B-O -Weight NOUN B-O -, PUNCT B-O -Body PROPN B-O -- PUNCT B-O -Mass NOUN B-O -- PUNCT B-O -Index PROPN B-O -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -waist NOUN B-O -- PUNCT B-O -circumference NOUN B-O -( PUNCT B-O -WC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -waist NOUN B-O -- PUNCT B-O -hip NOUN B-O -ratio NOUN B-O -( PUNCT B-O -WHR PROPN B-AC -) PUNCT B-O -] PUNCT B-O -, PUNCT B-O -clinical ADJ B-O -[ PUNCT B-O -systolic ADJ B-LF -blood NOUN I-LF -pressure NOUN I-LF -( PUNCT B-O -SBP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -diastolic ADJ B-LF -blood NOUN I-LF -pressure NOUN I-LF -( PUNCT B-O -DBP PROPN B-AC -) PUNCT B-O -] PUNCT B-O -and CCONJ B-O -biochemical ADJ B-O -measurements NOUN B-O -[ PUNCT B-O -Triglycerides NOUN B-LF -( PUNCT B-O -TG PROPN B-AC -) PUNCT B-O -, PUNCT B-O -High ADJ B-LF -Density NOUN I-LF -Lipoprotein NOUN I-LF -( PUNCT B-O -HDL PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Total PROPN B-LF -Cholesterol PROPN I-LF -( PUNCT B-O -TC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -HbA1c% PROPN B-AC -] PUNCT B-O -at ADP B-O -baseline NOUN B-O -and CCONJ B-O -follow NOUN B-O -- PUNCT B-O -up ADP B-O -were AUX B-O -compared VERB B-O -. PUNCT B-O - -Significance NOUN B-O -was AUX B-O -calculated VERB B-O -by ADP B-O -a DET B-O -two NUM B-O -- PUNCT B-O -tailed ADJ B-O -t NOUN B-O -test NOUN B-O -. PUNCT B-O - -* PUNCT B-O -p NOUN B-O -= SYM B-O -0.03 NUM B-O -. PUNCT B-O - -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -HMWCK PROPN B-AC -( PUNCT B-O -high ADJ B-LF -molecular ADJ I-LF -weight NOUN I-LF -cytokeratin NOUN I-LF -) PUNCT B-O -staining NOUN B-O -, PUNCT B-O -whose DET B-O -expression NOUN B-O -in ADP B-O -upper ADJ B-O -layers NOUN B-O -marks VERB B-O -squamous ADJ B-O -stratifying VERB B-O -epithelia NOUN B-O -. PUNCT B-O - -( PUNCT B-O -C NOUN B-O -) PUNCT B-O -Staining NOUN B-O -for ADP B-O -TMPRSS11B NOUN B-O -, PUNCT B-O -a DET B-O -marker NOUN B-O -of ADP B-O -squamous ADJ B-O -epithelia NOUN B-O -. PUNCT B-O - -( PUNCT B-O -D NOUN B-O -, PUNCT B-O -E NOUN B-O -) PUNCT B-O -Lenti PROPN B-O -- PUNCT B-O -SOX2 PROPN B-O -induces VERB B-O -hyperplasia NOUN B-O -. PUNCT B-O - -Taiwan PROPN B-O -’s PART B-O -National PROPN B-LF -Health PROPN I-LF -Insurance PROPN I-LF -( PUNCT B-O -NHI PROPN B-AC -) PUNCT B-O -program NOUN B-O -is AUX B-O -a DET B-O -universal ADJ B-O -insurance NOUN B-O -program NOUN B-O -that PRON B-O -was AUX B-O -launched VERB B-O -in ADP B-O -1995 NUM B-O -. PUNCT B-O - -We PRON B-O -conducted VERB B-O -a DET B-O -meta NOUN B-O -- ADJ B-O -analysis NOUN B-O -and CCONJ B-O -meta NOUN B-O -- ADJ B-O -regression NOUN B-O -of ADP B-O -randomized ADJ B-LF -controlled VERB I-LF -trials NOUN I-LF -( PUNCT B-O -RCTs PROPN B-AC -) PUNCT B-O -evaluating VERB B-O -SGLT2i PROPN B-AC -in ADP B-O -T1DM PROPN B-AC -to PART B-O -assess VERB B-O -moderators NOUN B-O -of ADP B-O -the DET B-O -relative ADJ B-LF -risk NOUN I-LF -( PUNCT B-O -RR PROPN B-AC -) PUNCT B-O -of ADP B-O -DKA PROPN B-AC -, PUNCT B-O -of ADP B-O -glycemic ADJ B-O -( PUNCT B-O -HbA1c NOUN B-O -, PUNCT B-O -fasting VERB B-O -plasma NOUN B-O -glucose NOUN B-O -, PUNCT B-O -continuous ADJ B-O -glucose NOUN B-O -monitoring NOUN B-O -parameters NOUN B-O -, PUNCT B-O -insulin NOUN B-O -dose NOUN B-O -, PUNCT B-O -and CCONJ B-O -insulin NOUN B-O -sensitivity NOUN B-O -indices NOUN B-O -) PUNCT B-O -and CCONJ B-O -non ADJ B-O -- ADJ B-O -glycemic ADJ B-O -( PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -systolic ADJ B-O -BP PROPN B-AC -, PUNCT B-O -renal ADJ B-O -function NOUN B-O -, PUNCT B-O -albuminuria NOUN B-O -, PUNCT B-O -and CCONJ B-O -diabetic ADJ B-O -eye NOUN B-O -disorders NOUN B-O -) PUNCT B-O -efficacy NOUN B-O -, PUNCT B-O -and CCONJ B-O -of ADP B-O -other ADJ B-O -safety NOUN B-O -outcomes NOUN B-O -( PUNCT B-O -including VERB B-O -hypoglycemia NOUN B-O -, PUNCT B-O -infections NOUN B-O -, PUNCT B-O -major ADJ B-O -adverse ADJ B-O -cardiovascular ADJ B-O -events NOUN B-O -, PUNCT B-O -and CCONJ B-O -death NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Diffusion PROPN B-LF -Tensor PROPN I-LF -Imaging PROPN I-LF -( PUNCT B-O -DTI PROPN B-AC -) PUNCT B-O -studies NOUN B-O -suggest VERB B-O -that SCONJ B-O -at ADP B-O -birth NOUN B-O -all DET B-O -major ADJ B-O -fiber NOUN B-O -systems NOUN B-O -are AUX B-O -in ADP B-O -place NOUN B-O -, PUNCT B-O -despite SCONJ B-O -low ADJ B-O -anisotropy NOUN B-O -value NOUN B-O -[ PUNCT B-O -70 NUM B-O -] PUNCT B-O -and CCONJ B-O -incomplete ADJ B-O -myelination NOUN B-O -[ PUNCT B-O -71 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Increasing VERB B-O -phytoene NOUN B-O -concentrations NOUN B-O -favor VERB B-O -phytofluene NOUN B-LF -release NOUN B-O -, PUNCT B-O -with ADP B-O -the DET B-O -z PROPN B-AC -: NOUN B-O -pf PROPN B-AC -ratio NOUN B-O -decreasing VERB B-O -from ADP B-O -ca X B-O -. PUNCT B-O - -4:1 NUM B-O -to ADP B-O -1:1 NUM B-O -( PUNCT B-O -Fig NOUN B-O -6B NUM B-O -, PUNCT B-O -dotted ADJ B-O -line NOUN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -underlying ADJ B-O -numerical ADJ B-O -data NOUN B-O -for ADP B-O -this DET B-O -figure NOUN B-O -can AUX B-O -be AUX B-O -found VERB B-O -in ADP B-O -S1 PROPN B-O -Data PROPN B-O -. PUNCT B-O - -dpi PROPN B-AC -, PUNCT B-O -days NOUN B-LF -postinoculation NOUN I-LF -; PUNCT B-O -N NOUN B-O -- PUNCT B-O -acetylneuraminic NOUN B-O -acid NOUN B-O -; PUNCT B-O -siaT PROPN B-AC -, PUNCT B-O -predicted VERB B-LF -sialic ADJ I-LF -acid NOUN I-LF -transporter NOUN I-LF -; PUNCT B-O -WT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -type NOUN I-LF -. PUNCT B-O - -CFA PROPN B-AC -, PUNCT B-O -complete ADJ B-LF -Freund PROPN I-LF -’s PART I-LF -adjuvant NOUN I-LF -; PUNCT B-O -DAPI PROPN B-AC -, PUNCT B-O -4′,6 NUM B-LF -- PUNCT I-LF -diamidino-2 NOUN I-LF -- PUNCT I-LF -phenylindole NOUN I-LF -; PUNCT B-O -DRG PROPN B-AC -, PUNCT B-O -dorsal ADJ B-LF -root NOUN I-LF -ganglia NOUN I-LF -; PUNCT B-O -EV PROPN B-AC -, PUNCT B-O -empty ADJ B-LF -vector NOUN I-LF -; PUNCT B-O -GFAP PROPN B-AC -, PUNCT B-O -glial ADJ B-LF -fibrillary ADJ I-LF -acidic ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -HSV PROPN B-AC -, PUNCT B-O -herpes NOUN B-LF -simplex NOUN I-LF -virus NOUN I-LF -; PUNCT B-O -Iba1 PROPN B-AC -, PUNCT B-O -ionized VERB B-LF -calcium NOUN I-LF -binding VERB I-LF -adaptor NOUN I-LF -molecule NOUN I-LF -1 NUM I-LF -; PUNCT B-O -MM PROPN B-AC -, PUNCT B-O -mismatch NOUN B-LF -ODN PROPN I-LF --ODNODN PROPN B-AC -; PUNCT B-O -NF200 PROPN B-O -, PUNCT B-O -neurofilament NOUN B-O -200 NUM B-O -; PUNCT B-O -ODN PROPN B-AC -, PUNCT B-O -oligodeoxynucleotide NOUN B-LF -; PUNCT B-O -SC PROPN B-AC -, PUNCT B-O -spinal ADJ B-LF -cord NOUN I-LF -; PUNCT B-O -SEM PROPN B-AC -, PUNCT B-O -standard ADJ B-LF -error NOUN I-LF -of ADP I-LF -the DET I-LF -mean NOUN I-LF -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -CHD PROPN B-AC -, PUNCT B-O -coronary ADJ B-LF -heart NOUN I-LF -disease NOUN I-LF -; PUNCT B-O -BMI PROPN B-AC -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -; PUNCT B-O -OR PROPN B-AC -, PUNCT B-O -odds NOUN B-LF -ratio NOUN I-LF -; PUNCT B-O -CI PROPN B-AC -, PUNCT B-O -confidence NOUN B-LF -interval NOUN I-LF -. PUNCT B-O - -Primaquine PROPN B-LF -( PUNCT B-O -PQ PROPN B-AC -) PUNCT B-O -actively ADV B-O -clears VERB B-O -mature ADJ B-O -Plasmodium PROPN B-O -falciparum NOUN B-O -gametocytes NOUN B-O -but CCONJ B-O -in ADP B-O -glucose-6 NOUN B-O -- PUNCT B-O -phosphate NOUN B-O -dehydrogenase NOUN B-O -deficient ADJ B-O -( PUNCT B-O -G6PDd NOUN B-O -) PUNCT B-O -individuals NOUN B-O -can AUX B-O -cause VERB B-O -hemolysis NOUN B-O -. PUNCT B-O - -Further ADV B-O -, PUNCT B-O -how SCONJ B-O -much ADJ B-O -effect NOUN B-O -variations NOUN B-O -in ADP B-O -r PROPN B-AC -have AUX B-O -on ADP B-O -the DET B-O -dynamics NOUN B-O -of ADP B-O -free ADJ B-O -virus NOUN B-O -depended VERB B-O -on ADP B-O -the DET B-O -magnitude NOUN B-O -of ADP B-O -the DET B-O -minimum ADJ B-LF -activation NOUN I-LF -rate NOUN I-LF -of ADP I-LF -latently ADV I-LF -infected VERB I-LF -cells NOUN I-LF -( PUNCT B-O -amin PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Homologous ADJ B-O -recombination NOUN B-O -can AUX B-O -also ADV B-O -have VERB B-O -a DET B-O -mutagenic ADJ B-O -outcome NOUN B-O -by ADP B-O -promoting VERB B-O -recombination NOUN B-O -between ADP B-O -nonallelic ADJ B-O -repeated VERB B-O -sequences NOUN B-O -, PUNCT B-O -leading VERB B-O -to PART B-O -genomic ADJ B-O -instability NOUN B-O -, PUNCT B-O -or CCONJ B-O -by ADP B-O -templating VERB B-O -repair VERB B-O -from ADP B-O -a DET B-O -homolog NOUN B-O -rather ADV B-O -than ADP B-O -a DET B-O -sister NOUN B-O -chromatid NOUN B-O -, PUNCT B-O -leading VERB B-O -to PART B-O -loss NOUN B-LF -of ADP I-LF -heterozygosity NOUN I-LF -( PUNCT B-O -LOH PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -a DET B-O -living VERB B-O -cell NOUN B-O -, PUNCT B-O -multiple ADJ B-O -pathways NOUN B-O -compete VERB B-O -to PART B-O -repair VERB B-O -the DET B-O -same ADJ B-O -kinds NOUN B-O -of ADP B-O -damage NOUN B-O -. PUNCT B-O - -The DET B-O -exact ADJ B-O -location NOUN B-O -of ADP B-O -Swt1 PROPN B-O -could AUX B-O -not PART B-O -be AUX B-O -determined VERB B-O -, PUNCT B-O -however ADV B-O -, PUNCT B-O -because SCONJ B-O -the DET B-O -abundance NOUN B-O -of ADP B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -( PUNCT B-O -GFP)- PROPN B-AC -or CCONJ B-O -immuno ADJ B-O -- PUNCT B-O -labeled VERB B-O -Swt1 PROPN B-O -expressed VERB B-O -from ADP B-O -the DET B-O -endogenous ADJ B-O -promoter NOUN B-O -was AUX B-O -too ADV B-O -low ADJ B-O -to PART B-O -be AUX B-O -visualized VERB B-O -( PUNCT B-O -unpublished ADJ B-O -data NOUN B-O -and CCONJ B-O -[ X B-O -18 NUM B-O -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -While SCONJ B-O -initiation NOUN B-O -requires VERB B-O -a DET B-O -rapid ADJ B-O -but CCONJ B-O -temporary ADJ B-O -disappearance NOUN B-O -of ADP B-O -Nrg1 PROPN B-O -via ADP B-O -activation NOUN B-O -of ADP B-O -the DET B-O -cAMP NOUN B-O -- PUNCT B-O -dependent ADJ B-O -protein NOUN B-O -kinase NOUN B-O -A NOUN B-O -pathway NOUN B-O -, PUNCT B-O -maintenance NOUN B-O -requires VERB B-O -the DET B-O -recruitment NOUN B-O -to ADP B-O -promoters NOUN B-O -of ADP B-O -the DET B-O -Hda1 NOUN B-O -histone NOUN B-O -deacetylase NOUN B-O -under ADP B-O -conditions NOUN B-O -of ADP B-O -reduced VERB B-O -signaling NOUN B-O -by ADP B-O -the DET B-O -target NOUN B-LF -of ADP I-LF -rapamycin NOUN I-LF -( PUNCT B-O -TOR PROPN B-AC -) PUNCT B-O -kinase NOUN B-O -, PUNCT B-O -leading VERB B-O -to ADP B-O -chromatin NOUN B-O -remodeling NOUN B-O -that PRON B-O -blocks VERB B-O -Nrg1 PROPN B-O -access NOUN B-O -to ADP B-O -the DET B-O -promoters NOUN B-O -of ADP B-O -hypha NOUN B-O -- PUNCT B-O -specific ADJ B-O -genes NOUN B-O -. PUNCT B-O - -Recent ADJ B-O -studies NOUN B-O -have AUX B-O -suggested VERB B-O -that SCONJ B-O -these DET B-O -diseases NOUN B-O -are AUX B-O -but ADV B-O -one NUM B-O -unique ADJ B-O -set NOUN B-O -of ADP B-O -immunoglobulin NOUN B-LF -- PUNCT I-LF -E NOUN I-LF -( PUNCT B-O -IgE)-mediated PROPN B-AC -allergic ADJ B-O -conditions NOUN B-O -, PUNCT B-O -linked VERB B-O -by ADP B-O -the DET B-O -common ADJ B-O -thread NOUN B-O -of ADP B-O -“ PUNCT B-O -atopic PROPN B-O -march PROPN B-O -” PUNCT B-O -[ PUNCT B-O -9 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Abbr PROPN B-O -. PUNCT B-O - -: PUNCT B-O -AN PROPN B-AC -– PUNCT B-O -antennal ADJ B-LF -nerve NOUN I-LF -; PUNCT B-O -CDM PROPN B-AC -– PUNCT B-O -cibarial NOUN B-O -dilator NOUN B-O -muscle NOUN B-O -; PUNCT B-O -CNS PROPN B-AC -– PUNCT B-O -central ADJ B-LF -nervous ADJ I-LF -system NOUN I-LF -. PUNCT B-O - -Strains NOUN B-O -: PUNCT B-O -DLY12943 PROPN B-O -, PUNCT B-O -DLY7593 PROPN B-O -( PUNCT B-O -B NOUN B-O -- NOUN B-O -D NOUN B-O -) PUNCT B-O -, PUNCT B-O -DLY22883 PROPN B-O -( PUNCT B-O -E NOUN B-O -) PUNCT B-O -, PUNCT B-O -DLY22928 PROPN B-O -( PUNCT B-O -F NOUN B-O -) PUNCT B-O -. PUNCT B-O - -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -KS PROPN B-O -, PUNCT B-O -Kolmogorov PROPN B-O -– PUNCT B-O -Smirnov PROPN B-O -; PUNCT B-O -MAT PROPN B-AC -, PUNCT B-O -mating NOUN B-LF -type NOUN I-LF -; PUNCT B-O -MFα1 PROPN B-AC -, PUNCT B-O -major ADJ B-LF -α PUNCT I-LF -- NOUN I-LF -factor NOUN I-LF -gene NOUN I-LF -1 NUM I-LF -; PUNCT B-O -sf PROPN B-AC -, PUNCT B-O -superfolder NOUN B-LF -; PUNCT B-O -TEF1 PROPN B-AC -, PUNCT B-O -translation NOUN B-LF -elongation NOUN I-LF -factor NOUN I-LF -1 NUM I-LF -. PUNCT B-O - -The DET B-O -Hopkins PROPN B-LF -Symptom PROPN I-LF -Checklist-37 PROPN I-LF -for ADP I-LF -Adolescents PROPN I-LF -( PUNCT B-O -HSCL-37A PROPN B-AC -; PUNCT B-O -[ PUNCT B-O -48 NUM B-O -] PUNCT B-O -) PUNCT B-O -examines VERB B-O -both CCONJ B-O -internalizing VERB B-O -symptoms NOUN B-O -such ADJ B-O -as ADP B-O -depression NOUN B-O -and CCONJ B-O -anxiety NOUN B-O -, PUNCT B-O -and CCONJ B-O -externalizing VERB B-O -symptoms NOUN B-O -. PUNCT B-O - -These DET B-O -studies NOUN B-O -also ADV B-O -demonstrated VERB B-O -variation NOUN B-O -in ADP B-O -transmission NOUN B-O -potential NOUN B-O -after ADP B-O -different ADJ B-O -ACTs PROPN B-AC -, PUNCT B-O -with ADP B-O -artemether NOUN B-LF -- PUNCT I-LF -lumefantrine NOUN I-LF -( PUNCT B-O -AL PROPN B-AC -) PUNCT B-O -being AUX B-O -associated VERB B-O -with ADP B-O -lower ADJ B-O -post ADJ B-O -- PUNCT B-O -treatment ADJ B-O -gametocyte ADJ B-O -carriage NOUN B-O -and CCONJ B-O -transmission NOUN B-O -potential NOUN B-O -compared VERB B-O -to ADP B-O -dihydroartemisinin NOUN B-LF -- PUNCT I-LF -piperaquine NOUN I-LF -( PUNCT B-O -DP PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -12 NUM B-O -, PUNCT B-O -13 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Alternating VERB B-O -phase NOUN B-O -radiofrequency NOUN B-LF -( PUNCT B-O -RF PROPN B-AC -) PUNCT B-O -pulse NOUN B-O -acquisition NOUN B-O -technique NOUN B-O -implying VERB B-O -the DET B-O -acquisition NOUN B-O -of ADP B-O -multiple ADJ B-O -images NOUN B-O -, PUNCT B-O -has AUX B-O -been AUX B-O -combined VERB B-O -with ADP B-O -the DET B-O -maximum ADJ B-O -- PUNCT B-O -intensity NOUN B-O -, PUNCT B-O -the DET B-O -complex ADJ B-O -- PUNCT B-O -sum NOUN B-O -, PUNCT B-O -the DET B-O -magnitude NOUN B-O -- PUNCT B-O -sum NOUN B-O -combinations NOUN B-O -to PART B-O -eliminate VERB B-O -them PRON B-O -. PUNCT B-O - -Common ADJ B-O -bacterial ADJ B-O -pathogens NOUN B-O -such ADJ B-O -as ADP B-O -Salmonella PROPN B-O -, PUNCT B-O -Shigella PROPN B-O -, PUNCT B-O -and CCONJ B-O -Yersinia PROPN B-O -spp NOUN B-O -. PUNCT B-O - -invade VERB B-O -the DET B-O -gut NOUN B-O -epithelial ADJ B-O -barrier NOUN B-O -, PUNCT B-O -preferentially ADV B-O -by ADP B-O -targeting VERB B-O -the DET B-O -relatively ADV B-O -small ADJ B-O -number NOUN B-O -of ADP B-O -M NOUN B-O -cells NOUN B-O -located VERB B-O -in ADP B-O -the DET B-O -follicle NOUN B-LF -- PUNCT I-LF -associated VERB I-LF -epithelium NOUN I-LF -( PUNCT B-O -FAE PROPN B-AC -) PUNCT B-O -[ X B-O -1–3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Data NOUN B-O -were AUX B-O -collected VERB B-O -from ADP B-O -articles NOUN B-O -published VERB B-O -in ADP B-O -2019 NUM B-O -in ADP B-O -the DET B-O -biomedical ADJ B-O -sciences NOUN B-O -journals NOUN B-O -: PUNCT B-O -British PROPN B-LF -Journal PROPN I-LF -of ADP I-LF -Pharmacology PROPN I-LF -( PUNCT B-O -BJP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Journal PROPN B-LF -of ADP I-LF -Pharmacy PROPN I-LF -and CCONJ I-LF -Pharmacology PROPN I-LF -( PUNCT B-O -JPP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Frontiers PROPN B-LF -in ADP I-LF -Pharmacology PROPN I-LF -( PUNCT B-O -FP PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Journal PROPN B-LF -of ADP I-LF -Cell PROPN I-LF -Biology PROPN I-LF -( PUNCT B-O -JCB PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Journal PROPN B-LF -of ADP I-LF -Cell PROPN I-LF -Science PROPN I-LF -( PUNCT B-O -JCS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Cells PROPN B-LF -( PUNCT B-O -CEL PROPN B-AC -) PUNCT B-O -, PUNCT B-O -Journal PROPN B-LF -of ADP I-LF -Biological PROPN I-LF -Chemistry PROPN I-LF -( PUNCT B-O -JBC PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Proceedings PROPN B-LF -of ADP I-LF -the DET I-LF -National PROPN I-LF -Academy PROPN I-LF -of ADP I-LF -Sciences PROPN I-LF -( PUNCT B-O -PNAS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -N NOUN B-O -= SYM B-O -200 NUM B-O -articles NOUN B-O -analyzed VERB B-O -in ADP B-O -each DET B-O -scientific ADJ B-O -journal NOUN B-O -. PUNCT B-O - -The DET B-O -24 NUM B-O -studies NOUN B-O -that PRON B-O -contributed VERB B-O -data NOUN B-O -on ADP B-O -the DET B-O -diagnosis NOUN B-O -and CCONJ B-O -treatment NOUN B-O -practices NOUN B-O -of ADP B-O -healthcare NOUN B-O -providers NOUN B-O -were AUX B-O -undertaken VERB B-O -in ADP B-O -ten NUM B-O -countries NOUN B-O -, PUNCT B-O -involving VERB B-O -a DET B-O -range NOUN B-O -of ADP B-O -cadres NOUN B-O -, PUNCT B-O -including VERB B-O -medical ADJ B-O -doctors NOUN B-O -and CCONJ B-O -nurses NOUN B-O -, PUNCT B-O -pharmacists NOUN B-O -, PUNCT B-O -drug NOUN B-O -vendors NOUN B-O -, PUNCT B-O -traditional ADJ B-LF -birth NOUN I-LF -attendants NOUN I-LF -( PUNCT B-O -TBAs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -community NOUN B-LF -health NOUN I-LF -workers NOUN I-LF -( PUNCT B-O -CHWs PROPN B-AC -) PUNCT B-O -( PUNCT B-O -Tables NOUN B-O -2 NUM B-O -and CCONJ B-O -3 NUM B-O -) PUNCT B-O -. PUNCT B-O - -fFN PROPN B-AC -, PUNCT B-O -fetal ADJ B-LF -fibronectin NOUN I-LF -; PUNCT B-O -IPD PROPN B-AC -, PUNCT B-O -individual ADJ B-LF -participant NOUN I-LF -data NOUN I-LF -; PUNCT B-O -IQR PROPN B-O -, PUNCT B-O -interquartile ADJ B-O -range NOUN B-O -; PUNCT B-O -SD NOUN B-O -, PUNCT B-O -standard ADJ B-O -deviation NOUN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -ITH PROPN B-AC -, PUNCT B-O -intra ADJ B-LF -- ADJ I-LF -tumour ADJ I-LF -heterogeneity NOUN I-LF -; PUNCT B-O -DNAm PROPN B-AC -, PUNCT B-O -DNA NOUN B-LF -methylation NOUN I-LF -; PUNCT B-O -OC PROPN B-AC -, PUNCT B-O -ovarian ADJ B-LF -cancer NOUN I-LF -; PUNCT B-O -UCEC PROPN B-AC -, PUNCT B-O -uterine ADJ B-LF -corpus NOUN I-LF -endometrial ADJ I-LF -carcinoma NOUN I-LF -; PUNCT B-O -BRCA PROPN B-AC -, PUNCT B-O -breast NOUN B-LF -cancer NOUN I-LF -invasive ADJ I-LF -carcinoma NOUN I-LF -. PUNCT B-O - -Also ADV B-O -, PUNCT B-O -F→ PROPN B-AC -, PUNCT B-O -dv1→ NOUN B-O -, PUNCT B-O -dΩ PROPN B-AC -and CCONJ B-O -σ PROPN B-AC -are AUX B-O -external ADJ B-O -force NOUN B-O -vector NOUN B-O -, PUNCT B-O -molecules NOUN B-O -of ADP B-O -class NOUN B-O -with ADP B-O -velocity NOUN B-O -v1 NOUN B-O -, PUNCT B-O -elementary ADJ B-LF -solid ADJ I-LF -angle NOUN I-LF -and CCONJ B-O -collision NOUN B-LF -cross NOUN I-LF -section NOUN I-LF -[ X B-O -5,6 NUM B-O -] PUNCT B-O -. PUNCT B-O - -RNA NOUN B-O -was AUX B-O -extracted VERB B-O -from ADP B-O -liver NOUN B-O -using VERB B-O -TRIzol PROPN B-O -reagent NOUN B-O -( PUNCT B-O -Life PROPN B-O -Technologies PROPN B-O -, PUNCT B-O -Carlsbad PROPN B-O -, PUNCT B-O -CA PROPN B-O -) PUNCT B-O -and CCONJ B-O -purified VERB B-O -using VERB B-O -the DET B-O -RNeasy PROPN B-O -kit NOUN B-O -( PUNCT B-O -Qiagen PROPN B-O -, PUNCT B-O -Valencia PROPN B-O -, PUNCT B-O -CA PROPN B-O -) PUNCT B-O -. PUNCT B-O - -RNA NOUN B-O -integrity NOUN B-O -was AUX B-O -verified VERB B-O -by ADP B-O -formaldehyde NOUN B-O -gel NOUN B-O -electrophoresis NOUN B-O -. PUNCT B-O - -cDNA NOUN B-O -was AUX B-O -synthesized VERB B-O -using VERB B-O -iScript PROPN B-O -( PUNCT B-O -BioRad PROPN B-O -, PUNCT B-O -Hercules PROPN B-O -, PUNCT B-O -CA PROPN B-O -) PUNCT B-O -; PUNCT B-O -quantitative ADJ B-LF -PCR NOUN I-LF -( PUNCT B-O -qPCR PROPN B-AC -) PUNCT B-O -was AUX B-O -performed VERB B-O -with ADP B-O -TaqMan PROPN B-O -® PROPN B-O -assay NOUN B-O -kits NOUN B-O -( PUNCT B-O -Life PROPN B-O -Technologies PROPN B-O -, PUNCT B-O -Carlsbad PROPN B-O -, PUNCT B-O -CA PROPN B-O -) PUNCT B-O -using VERB B-O -β PUNCT B-O -- NOUN B-O -glucuronidase NOUN B-O -as ADP B-O -the DET B-O -internal ADJ B-O -control NOUN B-O -gene NOUN B-O -. PUNCT B-O - -Previous ADJ B-O -studies NOUN B-O -have AUX B-O -implicated VERB B-O -that SCONJ B-O -prolonged VERB B-O -activation NOUN B-O -( PUNCT B-O -> PUNCT B-O -10 NUM B-O -min NOUN B-O -) PUNCT B-O -of ADP B-O -mGluR1/5 NOUN B-O -by ADP B-O -DHPG PROPN B-AC -can AUX B-O -stimulate VERB B-O -spinal ADJ B-O -excitatory ADJ B-O -interneurons NOUN B-O -to PART B-O -produce VERB B-O -endocannabinoids NOUN B-O -, PUNCT B-O -which PRON B-O -act VERB B-O -as ADP B-O -retrograde ADJ B-O -messengers NOUN B-O -to PART B-O -stimulate VERB B-O -Type-1 NOUN B-LF -cannabinoid NOUN I-LF -( PUNCT B-O -CB1 PROPN B-AC -) PUNCT B-O -receptors NOUN B-O -expressed VERB B-O -at ADP B-O -inhibitory ADJ B-O -nerve NOUN B-O -terminals NOUN B-O -[ PUNCT B-O -18 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Some DET B-O -TUNEL+ NOUN B-O -cells NOUN B-O -are AUX B-O -also ADV B-O -detected VERB B-O -in ADP B-O -the DET B-O -mantle NOUN B-O -zone NOUN B-O -of ADP B-O -the DET B-O -PSB PROPN B-AC -in ADP B-O -mutant ADJ B-O -embryos NOUN B-O -( PUNCT B-O -Div PROPN B-O -) PUNCT B-O -but CCONJ B-O -do AUX B-O -not PART B-O -correspond VERB B-O -to ADP B-O -CR PROPN B-AC -cells NOUN B-O -since SCONJ B-O -no DET B-O -loss NOUN B-O -of ADP B-O -Reln PROPN B-O -was AUX B-O -observed VERB B-O -in ADP B-O -the DET B-O -lateral ADJ B-LF -pallium NOUN B-O -. PUNCT B-O - -( PUNCT B-O -E NOUN B-O -– PUNCT B-O -H NOUN B-O -) PUNCT B-O -Immunofluorescence NOUN B-O -using VERB B-O -Dbx1 NOUN B-O -antisera NOUN B-O -showing VERB B-O -that SCONJ B-O -at ADP B-O -the DET B-O -septum ADJ B-O -dorsal ADJ B-O -Dbx1 NOUN B-O -+ NOUN B-O -cells NOUN B-O -are AUX B-O -deleted VERB B-O -in ADP B-O -mutant ADJ B-O -embryos NOUN B-O -( PUNCT B-O -F NOUN B-O -) PUNCT B-O -compared VERB B-O -to ADP B-O -control NOUN B-O -animals NOUN B-O -( PUNCT B-O -E NOUN B-O -) PUNCT B-O -whereas SCONJ B-O -ventral ADJ B-O -Dbx1 NOUN B-O -+ NOUN B-O -cells NOUN B-O -are AUX B-O -not PART B-O -( PUNCT B-O -compare VERB B-O -G PROPN B-O -and CCONJ B-O -H NOUN B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -situ ADJ B-O -hybridization NOUN B-O -for ADP B-O -Reln PROPN B-O -( PUNCT B-O -I NOUN B-O -, PUNCT B-O -K NOUN B-O -, PUNCT B-O -quantified VERB B-O -in ADP B-O -M PROPN B-O -) PUNCT B-O -and CCONJ B-O -p73 NOUN B-O -( PUNCT B-O -J PROPN B-O -, PUNCT B-O -L PROPN B-AC -, PUNCT B-O -quantified VERB B-O -in ADP B-O -N PROPN B-O -) PUNCT B-O -at ADP B-O -caudal ADJ B-O -levels NOUN B-O -shows VERB B-O -that SCONJ B-O -there PRON B-O -is VERB B-O -no DET B-O -significant ADJ B-O -difference NOUN B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -6 NUM B-O -) PUNCT B-O -in ADP B-O -the DET B-O -numbers NOUN B-O -of ADP B-O -Reln+ NOUN B-O -and CCONJ B-O -p73 NOUN B-O -+ NOUN B-O -cells NOUN B-O -between ADP B-O -E11.5 NUM B-O -control NOUN B-O -( PUNCT B-O -I NOUN B-O -and CCONJ B-O -J PROPN B-O -) PUNCT B-O -and CCONJ B-O -Dbx1DTA;Emx1iresCre PROPN B-O -embryos NOUN B-O -( PUNCT B-O -K NOUN B-O -and CCONJ B-O -L PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Quantifications NOUN B-O -of ADP B-O -the DET B-O -numbers NOUN B-O -of ADP B-O -Reln+ NOUN B-O -and CCONJ B-O -p73 NOUN B-O -+ NOUN B-O -cells NOUN B-O -in ADP B-O -L1 NOUN B-O -( PUNCT B-O -O NOUN B-O -) PUNCT B-O -and CCONJ B-O -L2 NOUN B-O -( PUNCT B-O -P NOUN B-O -) PUNCT B-O -DM PROPN B-AC -regions NOUN B-O -of ADP B-O -E12.5 NUM B-O -control NOUN B-O -( PUNCT B-O -white ADJ B-O -bars NOUN B-O -) PUNCT B-O -and CCONJ B-O -Dbx1DTA;Emx1iresCre PROPN B-O -embryos NOUN B-O -( PUNCT B-O -black ADJ B-O -bars NOUN B-O -) PUNCT B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -3 NUM B-O -) PUNCT B-O -. PUNCT B-O - -* PUNCT B-O -P<0.05 NUM B-O -. PUNCT B-O - -CoSMO PROPN B-AC -, PUNCT B-O -Cooperation NOUN B-LF -that PRON I-LF -is AUX I-LF -Synthetic ADJ I-LF -and CCONJ I-LF -Mutually ADV I-LF -Obligatory ADJ I-LF -. PUNCT B-O - -Propensity NOUN B-O -- PUNCT B-O -score NOUN B-O -- PUNCT B-O -matched VERB B-O -controls NOUN B-O -were AUX B-O -selected VERB B-O -from ADP B-O -9,246 NUM B-O -non ADJ B-O -- PUNCT B-O -SAMI PROPN B-AC -patients NOUN B-O -( PUNCT B-O -non ADJ B-O -- PUNCT B-O -SA PROPN B-AC -- PUNCT B-O -MI PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -association NOUN B-O -of ADP B-O -SA PROPN B-AC -and CCONJ B-O -outcomes NOUN B-O -including VERB B-O -all DET B-O -- PUNCT B-O -cause NOUN B-O -mortality NOUN B-O -and CCONJ B-O -major ADJ B-LF -adverse ADJ I-LF -cardiac ADJ I-LF -and CCONJ I-LF -cerebrovascular ADJ I-LF -events NOUN I-LF -( PUNCT B-O -MACCEs PROPN B-AC -) PUNCT B-O -were AUX B-O -analyzed VERB B-O -by ADP B-O -a DET B-O -Cox PROPN B-O -proportional ADJ B-O -hazards NOUN B-O -model NOUN B-O -. PUNCT B-O - -AMBA PROPN B-O -, PUNCT B-O -Allen PROPN B-O -Mouse PROPN B-O -Brain PROPN B-O -Atlas PROPN B-O -; PUNCT B-O -CE PROPN B-O -, PUNCT B-O -cerebellum NOUN B-O -; PUNCT B-O -Fndc5 PROPN B-O -, PUNCT B-O -fibronectin NOUN B-O -type NOUN B-O -III NUM B-O -domain NOUN B-O -containing VERB B-O -5 NUM B-O -; PUNCT B-O -HB PROPN B-O -, PUNCT B-O -hindbrain NOUN B-O -; PUNCT B-O -LAV PROPN B-O -, PUNCT B-O -lateral ADJ B-O -vestibular ADJ B-O -nucleus NOUN B-O -; PUNCT B-O -LC PROPN B-O -, PUNCT B-O -locus NOUN B-O -coeruleus NOUN B-O -; PUNCT B-O -MV PROPN B-O -, PUNCT B-O -medial ADJ B-O -vestibular ADJ B-O -nucleus NOUN B-O -; PUNCT B-O -OT PROPN B-O -, PUNCT B-O -optic ADJ B-O -tectum NOUN B-O -; PUNCT B-O -P56 PROPN B-O -, PUNCT B-O -postnatal ADJ B-O -day NOUN B-O -56 NUM B-O -; PUNCT B-O -Pp NOUN B-O -, PUNCT B-O -prepontine ADJ B-O -area NOUN B-O -; PUNCT B-O -SUV PROPN B-AC -, PUNCT B-O -superior ADJ B-LF -vestibular ADJ I-LF -nucleus NOUN I-LF -; PUNCT B-O -TH NOUN B-O -, PUNCT B-O -tyrosine NOUN B-O -hydroxylase NOUN B-O -; PUNCT B-O -ZBB PROPN B-AC -, PUNCT B-O -Zebrafish PROPN B-LF -Brain PROPN I-LF -Browser PROPN I-LF -. PUNCT B-O - -Descending VERB B-LF -DAD- PROPN B-AC -aortic ADJ I-LF -distensibility NOUN I-LF -. PUNCT B-O - -The DET B-O -present ADJ B-O -findings NOUN B-O -of ADP B-O -an DET B-O -association NOUN B-O -between ADP B-O -recent ADJ B-O -cannabis NOUN B-O -use NOUN B-O -and CCONJ B-O -psychotic ADJ B-O -features NOUN B-O -are AUX B-O -consistent ADJ B-O -with ADP B-O -reports NOUN B-O -of ADP B-O -cannabis NOUN B-O -creating VERB B-O -an DET B-O -acute ADJ B-O -toxic ADJ B-O -psychosis NOUN B-O -and CCONJ B-O -with ADP B-O -short ADJ B-O -- PUNCT B-O -duration NOUN B-O -effects NOUN B-O -in ADP B-O -laboratory NOUN B-O -studies NOUN B-O -of ADP B-O -high ADJ B-O -doses NOUN B-O -of ADP B-O -intravenous ADJ B-O -tetrahydrocannabinol NOUN B-LF -( PUNCT B-O -THC PROPN B-AC -) PUNCT B-O -in ADP B-O -35%–50 NUM B-O -% NOUN B-O -of ADP B-O -healthy ADJ B-O -participants NOUN B-O -[ PUNCT B-O -17,60,61 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This PRON B-O -overlaps VERB B-O -the DET B-O -values NOUN B-O -for ADP B-O -the DET B-O -mammalian ADJ B-O -stratum NOUN B-O -4 NUM B-O -and CCONJ B-O -3 NUM B-O -genes NOUN B-O -( PUNCT B-O -mean ADJ B-O -K NOUN B-O -s NOUN B-O -values NOUN B-O -8 NUM B-O -% NOUN B-O -and CCONJ B-O -30 NUM B-O -% NOUN B-O -, PUNCT B-O -respectively ADV B-O -) PUNCT B-O -; PUNCT B-O -these DET B-O -strata NOUN B-O -are AUX B-O -inferred VERB B-O -to PART B-O -have AUX B-O -ceased VERB B-O -recombining VERB B-O -between ADP B-O -the DET B-O -X NOUN B-O -and CCONJ B-O -Y NOUN B-O -30–50 NUM B-O -million NUM B-LF -years NOUN I-LF -ago ADV I-LF -( PUNCT B-O -MYA PROPN B-AC -) PUNCT B-O -for ADP B-O -stratum NOUN B-O -4 NUM B-O -, PUNCT B-O -and CCONJ B-O -80–130 NUM B-O -MYA PROPN B-AC -for ADP B-O -stratum NOUN B-O -3 NUM B-O -, PUNCT B-O -whereas SCONJ B-O -strata NOUN B-O -1 NUM B-O -and CCONJ B-O -2 NUM B-O -diverged VERB B-O -130–320 NUM B-O -MYA PROPN B-AC -[ PUNCT B-O -9,11 NUM B-O -] PUNCT B-O -. PUNCT B-O - -ChIP PROPN B-AC -, PUNCT B-O -chromatin NOUN B-LF -immunoprecipitation NOUN I-LF -and CCONJ I-LF -sequencing NOUN I-LF -; PUNCT B-O --SeqdnIκBα PROPN B-AC -, PUNCT B-O -dominant ADJ B-O -negative ADJ B-O -mutated VERB B-O -IκBα PROPN B-O -; PUNCT B-O -FDR PROPN B-AC -, PUNCT B-O -false ADJ B-LF -discovery NOUN I-LF -rate NOUN I-LF -; PUNCT B-O -GEO PROPN B-O -, PUNCT B-O -Gene PROPN B-O -Expression PROPN B-O -Omnibus PROPN B-O -; PUNCT B-O -hnRNP NOUN B-O -, PUNCT B-O -heterogeneous ADJ B-O -nuclear ADJ B-O -ribonucleoprotein NOUN B-O -; PUNCT B-O -IκBα PROPN B-O -, PUNCT B-O -NFKB PROPN B-O -inhibitor NOUN B-O -alpha NOUN B-O -; PUNCT B-O -NC PROPN B-O -, PUNCT B-O -nitrocellulose NOUN B-O -; PUNCT B-O -NF PROPN B-AC -, PUNCT B-O -nuclear ADJ B-LF -factor NOUN I-LF -kappa NOUN I-LF -B NOUN I-LF -; PUNCT B-O --κBP+I PROPN B-AC -, PUNCT B-O -phorbol NOUN B-O -12 NUM B-O -- PUNCT B-O -myristate NOUN B-O -13 NUM B-O -- PUNCT B-O -acetate NOUN B-O -and CCONJ B-O -ionomycin NOUN B-O -; PUNCT B-O -RNA PROPN B-AC -, PUNCT B-O -RNA NOUN B-LF -sequencing NOUN I-LF -; PUNCT B-O --SeqTet PROPN B-AC -, PUNCT B-O -tetracycline NOUN B-LF -. PUNCT B-O - -The DET B-O -concerted ADJ B-O -action NOUN B-O -of ADP B-O -the DET B-O -three NUM B-O -HIV-1 PROPN B-O -proteins NOUN B-O -Nef PROPN B-O -, PUNCT B-O -Env PROPN B-O -, PUNCT B-O -and CCONJ B-O -Vpu PROPN B-O -results VERB B-O -in ADP B-O -a DET B-O -complete ADJ B-O -removal NOUN B-O -of ADP B-O -CD4 NOUN B-O -from ADP B-O -the DET B-O -surface NOUN B-O -of ADP B-O -HIV PROPN B-O -infected VERB B-O -cells NOUN B-O -through ADP B-O -( PUNCT B-O -i X B-O -) PUNCT B-O -enhanced VERB B-O -routing NOUN B-O -of ADP B-O -CD4 NOUN B-O -to ADP B-O -the DET B-O -endoplasmic ADJ B-LF -reticulum NOUN I-LF -( PUNCT B-O -ER PROPN B-AC -) PUNCT B-O -degradation NOUN B-O -pathway NOUN B-O -[ PUNCT B-O -12],[13 X B-O -] PUNCT B-O -and CCONJ B-O -( PUNCT B-O -ii X B-O -) PUNCT B-O -activated VERB B-O -endocytosis NOUN B-O -and CCONJ B-O -lysosomal ADJ B-O -degradation NOUN B-O -[ PUNCT B-O -14],[15 X B-O -] PUNCT B-O -. PUNCT B-O - -Morphologic ADJ B-O -parameters NOUN B-O -collected VERB B-O -by ADP B-O -USG PROPN B-AC -, PUNCT B-O -such ADJ B-O -as ADP B-O -cross ADJ B-LF -- ADJ I-LF -sectional ADJ I-LF -area NOUN I-LF -( PUNCT B-O -CSA PROPN B-AC -) PUNCT B-O -obtained VERB B-O -from ADP B-O -transverse ADJ B-O -scans NOUN B-O -, PUNCT B-O -provide VERB B-O -useful ADJ B-O -information NOUN B-O -complementary ADJ B-O -to ADP B-O -electrophysiological ADJ B-O -data NOUN B-O -[ PUNCT B-O -11–13 NUM B-O -] PUNCT B-O -. PUNCT B-O - -TNAP PROPN B-AC -dephosphorylates VERB B-O -poly NOUN B-O -- PUNCT B-O -inosine NOUN B-O -: PUNCT B-O -cytosine NOUN B-O -( PUNCT B-O -Toll PROPN B-LF -- PUNCT I-LF -like ADJ I-LF -receptor NOUN I-LF -( PUNCT B-O -TLR PROPN B-AC -) PUNCT B-O -3 NUM B-O -agonist NOUN B-O -) PUNCT B-O -and CCONJ B-O -LPS PROPN B-AC -from ADP B-O -Klebsiella PROPN B-O -pneumoniae NOUN B-O -and CCONJ B-O -Salmonella PROPN B-O -minnesota PROPN B-O -( PUNCT B-O -TLR4 PROPN B-O -agonists NOUN B-O -) PUNCT B-O -. PUNCT B-O - -HPLC PROPN B-AC -analysis NOUN B-O -was AUX B-O -carried VERB B-O -out ADP B-O -using VERB B-O -an DET B-O -Agilent PROPN B-O -1260 NUM B-O -Infinity PROPN B-O -system NOUN B-O -( PUNCT B-O -Agilent PROPN B-O -Technologies PROPN B-O -) PUNCT B-O -with ADP B-O -ultraviolet NOUN B-LF -( PUNCT B-O -UV PROPN B-AC -) PUNCT B-O -detection NOUN B-O -at ADP B-O -278 NUM B-O -nm NOUN B-O -( PUNCT B-O -maximum ADJ B-O -absorbance NOUN B-O -of ADP B-O -Cm PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -44 NUM B-O -] PUNCT B-O -. PUNCT B-O - -GFP PROPN B-AC -, PUNCT B-O -green ADJ B-LF -fluorescent ADJ I-LF -protein NOUN I-LF -; PUNCT B-O -PS PROPN B-AC -, PUNCT B-O -phosphatidylserine NOUN B-LF -; PUNCT B-O -UAS PROPN B-AC -, PUNCT B-O -upstream ADJ B-LF -activating VERB I-LF -sequence NOUN I-LF -. PUNCT B-O - -Among ADP B-O -urban ADJ B-O -, PUNCT B-O -migrant NOUN B-O -, PUNCT B-O -and CCONJ B-O -rural ADJ B-O -men NOUN B-O -the DET B-O -age- NOUN B-O -and CCONJ B-O -factory NOUN B-O -- PUNCT B-O -adjusted VERB B-O -percentages NOUN B-O -classified VERB B-O -as ADP B-O -obese ADJ B-O -( PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -[ X B-O -BMI PROPN B-AC -] X B-O -> NUM B-O -25 NUM B-O -kg NOUN B-O -/ SYM B-O -m2 NOUN B-O -) PUNCT B-O -were AUX B-O -41.9 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval NOUN I-LF -[ X B-O -CI PROPN B-AC -] X B-O -39.1–44.7 NUM B-O -) PUNCT B-O -, PUNCT B-O -37.8 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -35.0–40.6 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -19.0 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -17.0–21.0 NUM B-O -) PUNCT B-O -, PUNCT B-O -respectively ADV B-O -, PUNCT B-O -and CCONJ B-O -as ADP B-O -diabetic ADJ B-O -were AUX B-O -13.5 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -11.6–15.4 NUM B-O -) PUNCT B-O -, PUNCT B-O -14.3 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -12.2–16.4 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -6.2 NUM B-O -% NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -5.0–7.4 NUM B-O -) PUNCT B-O -, PUNCT B-O -respectively ADV B-O -. PUNCT B-O - -Viruses NOUN B-O -cause VERB B-O -respiratory ADJ B-LF -tract NOUN I-LF -infections NOUN I-LF -( PUNCT B-O -RTIs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -if SCONJ B-O -severe ADJ B-O -, PUNCT B-O -can AUX B-O -lead VERB B-O -to ADP B-O -a DET B-O -visit NOUN B-O -to ADP B-O -the DET B-O -Emergency PROPN B-LF -Department PROPN I-LF -( PUNCT B-O -ED PROPN B-AC -) PUNCT B-O -and CCONJ B-O -hospitalization NOUN B-O -. PUNCT B-O - -MDA PROPN B-AC -, PUNCT B-O -mass PROPN B-LF -drug PROPN I-LF -administration NOUN I-LF -; PUNCT B-O -IRS PROPN B-AC -, PUNCT B-O -indoor ADJ B-LF -residual NOUN I-LF -spraying NOUN I-LF -; PUNCT B-O -rfMDA PROPN B-AC -, PUNCT B-O -reactive ADJ B-LF -focal ADJ I-LF -mass PROPN B-LF -drug PROPN I-LF -administration NOUN I-LF -; PUNCT B-O -LLIN PROPN B-AC -, PUNCT B-O -long ADJ B-LF -lasting ADJ I-LF -insecticidal ADJ I-LF -nets NOUN I-LF -; PUNCT B-O -NMCP PROPN B-AC -, PUNCT B-O -national ADJ B-O -malaria NOUN B-O -control NOUN B-O -programme NOUN B-O -; PUNCT B-O -Contr PROPN B-O -, PUNCT B-O -contribution NOUN B-O -; PUNCT B-O -Ref PROPN B-O -, PUNCT B-O -reference NOUN B-O -. PUNCT B-O - -Exploring VERB B-O -potential ADJ B-O -subgroup NOUN B-O -effects NOUN B-O -of ADP B-O -maternal ADJ B-O -age NOUN B-O -, PUNCT B-O -parity NOUN B-O -, PUNCT B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -fetal ADJ B-O -sex NOUN B-O -is AUX B-O -therefore ADV B-O -impossible ADJ B-O -in ADP B-O -individual ADJ B-O -trials NOUN B-O -. PUNCT B-O - -This DET B-O -process NOUN B-O -can AUX B-O -be AUX B-O -accomplished VERB B-O -by ADP B-O -alternative ADJ B-O -precursor NOUN B-LF -messenger NOUN I-LF -RNA NOUN I-LF -( PUNCT B-O -pre-mRNA PROPN B-AC -) PUNCT B-O -splicing NOUN B-O -. PUNCT B-O - -CIN PROPN B-AC -, PUNCT B-O -cervical ADJ B-LF -intraepithelial ADJ I-LF -neoplasia NOUN I-LF -. PUNCT B-O - -De X B-O -novo X B-O -pathogenic ADJ B-O -variants NOUN B-O -in ADP B-O -Histone NOUN B-LF -- NOUN I-LF -lysine NOUN I-LF -N NOUN I-LF -- NOUN I-LF -methyltransferase NOUN I-LF -2D PROPN I-LF -( PUNCT B-O -KMT2D PROPN B-AC -) PUNCT B-O -are AUX B-O -causative ADJ B-O -in ADP B-O -up ADP B-O -to PART B-O -76 NUM B-O -% NOUN B-O -of ADP B-O -KS PROPN B-O -patients NOUN B-O -[ PUNCT B-O -18,19 NUM B-O -] PUNCT B-O -. PUNCT B-O - -* PUNCT B-O -Reproductive ADJ B-O -/ SYM B-O -antenatal ADJ B-O -health NOUN B-O -: PUNCT B-O -Reproductive ADJ B-O -/ SYM B-O -antenatal ADJ B-O -knowledge NOUN B-O -, PUNCT B-O -medical ADJ B-O -abortion NOUN B-O -, PUNCT B-O -facility NOUN B-O -delivery NOUN B-O -, PUNCT B-O -child NOUN B-O -dietary ADJ B-O -diversity NOUN B-O -. PUNCT B-O - -†Non ADJ B-O -- ADJ I-LF -communicable ADJ I-LF -diseases NOUN I-LF -: PUNCT B-O -Diabetes NOUN B-O -, PUNCT B-O -hypertension NOUN B-O -. PUNCT B-O - -‡One NUM B-O -ongoing ADJ B-O -NCD PROPN B-AC -trial NOUN B-O -is AUX B-O -a DET B-O -multicenter NOUN B-O -study NOUN B-O -in ADP B-O -South PROPN B-O -Africa PROPN B-O -and CCONJ B-O -Malawi PROPN B-O -, PUNCT B-O -hence ADV B-O -the DET B-O -number NOUN B-O -of ADP B-O -symbols NOUN B-O -exceeds VERB B-O -the DET B-O -number NOUN B-O -of ADP B-O -included VERB B-O -trials NOUN B-O -by ADP B-O -one NUM B-O -. PUNCT B-O - -§ PUNCT B-O -Map NOUN B-O -developed VERB B-O -by ADP B-O -use NOUN B-O -of ADP B-O -mapchart.net NOUN B-O -. PUNCT B-O - -Phase NOUN B-O -contrast NOUN B-O -cine NOUN B-O -gradient NOUN B-O -echo NOUN B-O -sequence NOUN B-O -was AUX B-O -also ADV B-O -obtained VERB B-O -to PART B-O -evaluate VERB B-O -aortic ADJ B-O -stiffness NOUN B-O -including VERB B-O -ascending VERB B-O -and CCONJ B-O -descending ADJ B-LF -aortic ADJ I-LF -distensibility NOUN I-LF -( PUNCT B-O -AAD NOUN B-O -and CCONJ B-O -DAD PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -pulse NOUN B-LF -wave NOUN I-LF -velocity NOUN I-LF -( PUNCT B-O -PWV PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -16 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Streptokinase PROPN B-O -was AUX B-O -administered VERB B-O -in ADP B-O -seven NUM B-O -( PUNCT B-O -6.3 NUM B-O -% NOUN B-O -) NOUN B-O -patients NOUN B-O -with ADP B-O -STEMI PROPN B-AC -. PUNCT B-O - -Primary ADJ B-O -percutaneous ADJ B-LF -coronary ADJ I-LF -intervention NOUN I-LF -( PUNCT B-O -PCI PROPN B-AC -) NOUN B-O -was AUX B-O -done VERB B-O -in ADP B-O -six NUM B-O -( PUNCT B-O -3.9 NUM B-O -% NOUN B-O -) NOUN B-O -patients NOUN B-O -with ADP B-O -STEMI PROPN B-AC -. PUNCT B-O - -Loading VERB B-O -dose NOUN B-O -of ADP B-O -aspirin NOUN B-O -and CCONJ B-O -clopidogrel NOUN B-O -were AUX B-O -administered VERB B-O -in ADP B-O -the DET B-O -emergency NOUN B-O -setting NOUN B-O -in ADP B-O -about ADV B-O -63.8 NUM B-O -% NOUN B-O -and CCONJ B-O -62.8 NUM B-O -% NOUN B-O -of ADP B-O -patients NOUN B-O -, PUNCT B-O -respectively ADV B-O -. PUNCT B-O - -Overall ADJ B-O -and CCONJ B-O -age NOUN B-O -- ADJ B-O -specific ADJ B-O -meta ADJ B-O -- ADJ B-O -analytic ADJ B-O -estimates NOUN B-O -of ADP B-O -proportion NOUN B-O -positive ADJ B-O -were AUX B-O -multiplied VERB B-O -by ADP B-O -LRI PROPN B-AC -hospitalization NOUN B-O -and CCONJ B-O -LRI PROPN B-AC -episode NOUN B-O -estimates NOUN B-O -for ADP B-O -adults NOUN B-O -≥20 NUM B-O -years NOUN B-O -, PUNCT B-O -which PRON B-O -were AUX B-O -from ADP B-O -the DET B-O -Global PROPN B-LF -Burden PROPN I-LF -of ADP I-LF -Disease PROPN I-LF -( PUNCT B-O -GBD PROPN B-AC -) PUNCT B-O -2017 NUM B-O -study NOUN B-O -[ PUNCT B-O -10 NUM B-O -] PUNCT B-O -, PUNCT B-O -obtained VERB B-O -for ADP B-O -calendar NOUN B-O -year NOUN B-O -2016 NUM B-O -for ADP B-O -this DET B-O -analysis NOUN B-O -. PUNCT B-O - -cART PROPN B-AC -, PUNCT B-O -combined ADJ B-O -antiretroviral ADJ B-O -therapy NOUN B-O -; PUNCT B-O -CI PROPN B-O -, PUNCT B-O -confidence NOUN B-O -interval NOUN B-O -; PUNCT B-O -DTG PROPN B-AC -, PUNCT B-O -dolutegravir NOUN B-LF -; PUNCT B-O -FTC PROPN B-AC -, PUNCT B-O -emtricitabine NOUN B-LF -; PUNCT B-O -ITT PROPN B-AC -, PUNCT B-O -intention NOUN B-LF -- PUNCT I-LF -to PART I-LF -- PUNCT I-LF -treat VERB I-LF -; PUNCT B-O -PP PROPN B-AC -, PUNCT B-O -per ADP B-O -- PUNCT B-O -protocol NOUN B-O -. PUNCT B-O - -People NOUN B-O -with ADP B-O -mental ADJ B-O -illnesses NOUN B-O -: PUNCT B-O -Patients NOUN B-O -under ADP B-O -psychiatric ADJ B-O -medications NOUN B-O -for ADP B-O -mental ADJ B-O -illnesses NOUN B-O -whose DET B-O -identity NOUN B-O -were AUX B-O -informed VERB B-O -by ADP B-O -Female PROPN B-LF -Community PROPN I-LF -Health PROPN I-LF -Volunteers PROPN I-LF -( PUNCT B-O -FCHVs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -PHC PROPN B-AC -health NOUN B-O -workers NOUN B-O -or CCONJ B-O -secondary ADJ B-O -health NOUN B-O -service NOUN B-O -providers NOUN B-O -. PUNCT B-O - -Wild ADJ B-LF -- PUNCT I-LF -type NOUN I-LF -( PUNCT B-O -WT PROPN B-AC -) PUNCT B-O -CD45.1 NOUN B-O -and CCONJ B-O -CD45.2 NOUN B-O -mice NOUN B-O -were AUX B-O -bred VERB B-O -and CCONJ B-O -maintained VERB B-O -in ADP B-O -conventional ADJ B-O -pathogen NOUN B-O -- PUNCT B-O -free ADJ B-O -colonies NOUN B-O -at ADP B-O -either CCONJ B-O -the DET B-O -National PROPN B-O -Institute PROPN B-O -for ADP B-O -Medical PROPN B-O -Research PROPN B-O -( PUNCT B-O -London PROPN B-O -, PUNCT B-O -United PROPN B-O -Kingdom PROPN B-O -) PUNCT B-O -or CCONJ B-O -at ADP B-O -the DET B-O -Royal PROPN B-O -Free PROPN B-O -Campus PROPN B-O -of ADP B-O -University PROPN B-O -College PROPN B-O -London PROPN B-O -. PUNCT B-O - -We PRON B-O -undertook VERB B-O -meta NOUN B-O -- PUNCT B-O -analyses NOUN B-O -using VERB B-O -RevMan PROPN B-O -5.3 NUM B-O -[ X B-O -30 NUM B-O -] X B-O -using VERB B-O -random ADJ B-O -- PUNCT B-O -effects NOUN B-O -models NOUN B-O -and CCONJ B-O -calculated VERB B-O -relative ADJ B-LF -risks NOUN I-LF -( PUNCT B-O -RRs PROPN B-AC -) PUNCT B-O -and CCONJ B-O -mean ADJ B-LF -differences NOUN I-LF -( PUNCT B-O -MDs PROPN B-AC -) PUNCT B-O -with ADP B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -intervals NOUN I-LF -( PUNCT B-O -CIs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -To PART B-O -quantify VERB B-O -time NOUN B-O -- PUNCT B-O -dependent ADJ B-O -changes NOUN B-O -in ADP B-O -synaptic ADJ B-O -gain NOUN B-O -we PRON B-O -used VERB B-O -an DET B-O -“ PUNCT B-O -Adaptation PROPN B-LF -Index PROPN I-LF -” PUNCT B-O -( PUNCT B-O -AI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -calculated VERB B-O -as ADP B-O -the DET B-O -ratio NOUN B-O -between ADP B-O -the DET B-O -peak ADJ B-O -initial ADJ B-O -response NOUN B-O -to ADP B-O -an DET B-O -increase NOUN B-O -in ADP B-O -contrast NOUN B-O -and CCONJ B-O -the DET B-O -later ADJ B-O -steady ADJ B-O -- PUNCT B-O -state NOUN B-O -response NOUN B-O -. PUNCT B-O - -During ADP B-O -the DET B-O -course NOUN B-O -of ADP B-O -this DET B-O -study NOUN B-O -, PUNCT B-O -an DET B-O -updated VERB B-O -, PUNCT B-O -larger ADJ B-O -GWAS PROPN B-AC -dataset NOUN B-O -for ADP B-O -coronary ADJ B-LF -artery NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -CAD PROPN B-AC -) PUNCT B-O -became VERB B-O -publicly ADV B-O -available ADJ B-O -( PUNCT B-O -CARDIoGRAMplusC4D PROPN B-O -Consortium PROPN B-O -, PUNCT B-O -release NOUN B-O -2015 NUM B-O -[ X B-O -41 NUM B-O -] PUNCT B-O -) PUNCT B-O -; PUNCT B-O -we PRON B-O -therefore ADV B-O -redid VERB B-O -the DET B-O -analysis NOUN B-O -for ADP B-O -CAD PROPN B-AC -using VERB B-O -the DET B-O -release NOUN B-O -2015 NUM B-O -data NOUN B-O -. PUNCT B-O - -Rate NOUN B-O -ratio NOUN B-O -( PUNCT B-O -RR NOUN B-O -) PUNCT B-O -, PUNCT B-O -95 NUM B-O -% NOUN B-O -credible ADJ B-LF -interval NOUN I-LF -( PUNCT B-O -CrI PROPN B-AC -) PUNCT B-O -in ADP B-O -brackets NOUN B-O -, PUNCT B-O -significant ADJ B-O -predictions NOUN B-O -in ADP B-O -bold NOUN B-O -. PUNCT B-O - -To PART B-O -analyze VERB B-O -the DET B-O -amount NOUN B-O -of ADP B-O -asymmetry NOUN B-O -between ADP B-O -the DET B-O -dominant ADJ B-O -and CCONJ B-O -non ADJ B-O -- ADJ B-O -dominant ADJ B-O -lower ADJ B-O -limbs NOUN B-O -, PUNCT B-O -we PRON B-O -used VERB B-O -the DET B-O -absolute ADJ B-LF -symmetry NOUN I-LF -index NOUN I-LF -( PUNCT B-O -ASI PROPN B-AC -) PUNCT B-O -and CCONJ B-O -the DET B-O -symmetry NOUN B-LF -index NOUN I-LF -( PUNCT B-O -SI PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -31–34 NUM B-O -] PUNCT B-O -. PUNCT B-O - -This DET B-O -method NOUN B-O -, PUNCT B-O -called VERB B-O -optimal ADJ B-LF -metabolic ADJ I-LF -network NOUN I-LF -identification NOUN I-LF -( PUNCT B-O -OMNI PROPN B-AC -) PUNCT B-O -, PUNCT B-O -allows VERB B-O -efficient ADJ B-O -identification NOUN B-O -of ADP B-O -the DET B-O -set NOUN B-O -of ADP B-O -reactions NOUN B-O -that PRON B-O -results VERB B-O -in ADP B-O -the DET B-O -best ADJ B-O -agreement NOUN B-O -between ADP B-O -in ADP B-O -silico NOUN B-O -predicted VERB B-O -and CCONJ B-O -experimentally ADV B-O -measured VERB B-O -flux NOUN B-O -distributions NOUN B-O -. PUNCT B-O - -We PRON B-O -then ADV B-O -removed VERB B-O -any DET B-O -variants NOUN B-O -with ADP B-O -flags NOUN B-O -“ PUNCT B-O -badRead ADJ B-O -, PUNCT B-O -” PUNCT B-O -mapping NOUN B-LF -quality NOUN I-LF -( PUNCT B-O -“ PUNCT B-O -MQ PROPN B-AC -” PUNCT B-O -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -quality NOUN B-LF -depth NOUN I-LF -( PUNCT B-O -“ PUNCT B-O -QD PROPN B-AC -” PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -After ADP B-O -fixation NOUN B-O -and CCONJ B-O -permeabilization NOUN B-O -, PUNCT B-O -the DET B-O -cells NOUN B-O -were AUX B-O -stained VERB B-O -for ADP B-O -pSHIP PROPN B-AC -and CCONJ B-O -analyzed VERB B-O -using VERB B-O -confocal ADJ B-LF -microscopy NOUN I-LF -( PUNCT B-O -CFm PROPN B-AC -) PUNCT B-O -or CCONJ B-O -flow NOUN B-O -cytometry NOUN B-O -( PUNCT B-O -A NOUN B-O -, PUNCT B-O -B NOUN B-O -and CCONJ B-O -D NOUN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -mean ADJ B-LF -fluorescence NOUN I-LF -intensity NOUN I-LF -( PUNCT B-O -MFI PROPN B-AC -) PUNCT B-O -of ADP B-O -pSHIP PROPN B-AC -was AUX B-O -generated VERB B-O -using VERB B-O -NIS PROPN B-O -- PUNCT B-O -Elements PROPN B-O -AR PROPN B-O -3.2 NUM B-O -software NOUN B-O -( PUNCT B-O -C NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Flow NOUN B-O -cytometry NOUN B-O -analysis NOUN B-O -of ADP B-O -the DET B-O -MFI PROPN B-AC -of ADP B-O -pSHIP PROPN B-AC -after ADP B-O -stimulation NOUN B-O -with ADP B-O -sAgs PROPN B-AC -( PUNCT B-O -D NOUN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -Pearson PROPN B-O -’s PART B-O -correlation NOUN B-O -coefficients NOUN B-O -between ADP B-O -BCR PROPN B-AC -and CCONJ B-O -pSHIP PROPN B-AC -staining NOUN B-O -in ADP B-O -sAg PROPN B-AC -- PUNCT B-O -stimulated VERB B-O -cells NOUN B-O -were AUX B-O -determined VERB B-O -using VERB B-O -NIS PROPN B-O -- PUNCT B-O -Elements PROPN B-O -AR PROPN B-O -3.2 NUM B-O -software NOUN B-O -( PUNCT B-O -E NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Shown VERB B-O -are AUX B-O -representative ADJ B-O -images NOUN B-O -at ADP B-O -indicated VERB B-O -times NOUN B-O -and CCONJ B-O -the DET B-O -average ADJ B-O -values NOUN B-O -( PUNCT B-O -±SD NOUN B-O -) PUNCT B-O -of ADP B-O -about ADV B-O -50 NUM B-O -cells NOUN B-O -from ADP B-O -3 NUM B-O -independent ADJ B-O -experiments NOUN B-O -. PUNCT B-O - -Furthermore ADV B-O -, PUNCT B-O -higher ADJ B-O -prevalence NOUN B-O -of ADP B-O -tumor NOUN B-LF -- PUNCT I-LF -infiltrating VERB I-LF -lymphocytes NOUN I-LF -( PUNCT B-O -TILs PROPN B-AC -) PUNCT B-O -has AUX B-O -been AUX B-O -associated VERB B-O -with ADP B-O -better ADJ B-O -prognosis NOUN B-O -[ PUNCT B-O -19–22 NUM B-O -] PUNCT B-O -, PUNCT B-O -irrespective ADV B-O -of ADP B-O -the DET B-O -chemotherapy NOUN B-O -administered VERB B-O -, PUNCT B-O -and CCONJ B-O -also ADV B-O -with ADP B-O -a DET B-O -higher ADJ B-O -rate NOUN B-O -of ADP B-O -pCR PROPN B-AC -to ADP B-O -neoadjuvant ADJ B-O -anthracycline NOUN B-O -- PUNCT B-O -based VERB B-O -chemotherapy NOUN B-O -in ADP B-O -TNBC PROPN B-AC -[ PUNCT B-O -23 NUM B-O -] PUNCT B-O -. PUNCT B-O - -To PART B-O -address VERB B-O -this DET B-O -question NOUN B-O -, PUNCT B-O -hairpin NOUN B-O -RNA NOUN B-LF -- PUNCT I-LF -induced VERB I-LF -gene NOUN I-LF -silencing NOUN I-LF -( PUNCT B-O -RNAi PROPN B-AC -) PUNCT B-O -was AUX B-O -adopted VERB B-O -. PUNCT B-O - -The DET B-O -first ADJ B-O -antimetabolite NOUN B-O -drug NOUN B-O -that PRON B-O -was AUX B-O -developed VERB B-O -to PART B-O -specifically ADV B-O -target VERB B-O -cancer NOUN B-O -cells NOUN B-O -was AUX B-O -the DET B-O -pyrimidine NOUN B-O -analogue NOUN B-O -5 NUM B-LF -- PUNCT I-LF -fluorouracil NOUN I-LF -, PUNCT B-O -5-FU PROPN B-AC -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -5 PROPN B-AC -targets VERB B-O -several ADJ B-O -cellular ADJ B-O -mechanisms NOUN B-O -through ADP B-O -its PRON B-O -activated VERB B-O -metabolites NOUN B-O -FdUMP NOUN B-O -, PUNCT B-O -FUTP PROPN B-O -and CCONJ B-O -FdUTP NOUN B-O -[ PUNCT B-O -2–3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Cb PROPN B-O -, PUNCT B-O -Coxiella PROPN B-O -burnetii NOUN B-O -; PUNCT B-O -GO PROPN B-AC -, PUNCT B-O -Gene PROPN B-LF -Ontology NOUN I-LF -; PUNCT B-O -praw NOUN B-O -, PUNCT B-O -original ADJ B-O -p NOUN B-O -- PUNCT B-O -value NOUN B-O -; PUNCT B-O -padj NOUN B-O -, PUNCT B-O -adjusted VERB B-O -p NOUN B-O -- PUNCT B-O -value NOUN B-O -according VERB B-O -to ADP B-O -the DET B-O -Benjamini PROPN B-O -- PUNCT B-O -Hochberg PROPN B-O -multiple ADJ B-O -test NOUN B-O -correction NOUN B-O -[ PUNCT B-O -43 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -conceptus NOUN B-O -was AUX B-O -dissected VERB B-O -, PUNCT B-O -and CCONJ B-O -transcriptome NOUN B-O -data NOUN B-O -were AUX B-O -generated VERB B-O -for ADP B-O -extraembryonic ADJ B-O -tissue NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -the DET B-O -endometrium NOUN B-O -was AUX B-O -dissected VERB B-O -into ADP B-O -caruncular ADJ B-O -( PUNCT B-O -gland NOUN B-O -- PUNCT B-O -free ADJ B-O -) PUNCT B-O -and CCONJ B-O -intercaruncular ADJ B-O -( PUNCT B-O -containing VERB B-O -endometrial ADJ B-O -glands NOUN B-O -) PUNCT B-O -areas NOUN B-O -, PUNCT B-O -and CCONJ B-O -transcriptome NOUN B-O -data NOUN B-O -were AUX B-O -generated VERB B-O -from ADP B-O -both DET B-O -regions NOUN B-O -of ADP B-O -the DET B-O -endometrium NOUN B-O -( PUNCT B-O -Fig NOUN B-O -1A NUM B-O -) PUNCT B-O -. PUNCT B-O - -Therefore ADV B-O -, PUNCT B-O -the DET B-O -data NOUN B-O -set NOUN B-O -analyzed VERB B-O -was AUX B-O -comprised VERB B-O -of ADP B-O -three NUM B-O -sample NOUN B-O -types NOUN B-O -collected VERB B-O -from ADP B-O -each DET B-O -pregnancy NOUN B-O -: PUNCT B-O -extraembryonic ADJ B-O -, PUNCT B-O -caruncular ADJ B-O -, PUNCT B-O -and CCONJ B-O -intercaruncular ADJ B-O -tissues NOUN B-O -( PUNCT B-O -Fig NOUN B-O -1B NUM B-O -) PUNCT B-O -. PUNCT B-O - -Alignment NOUN B-O -of ADP B-O -the DET B-O -sequences NOUN B-O -to ADP B-O -the DET B-O -B. PROPN B-O -taurus PROPN B-O -genome NOUN B-O -( PUNCT B-O -University PROPN B-LF -of ADP I-LF -Maryland PROPN I-LF -[ X B-O -UMD PROPN B-AC -] X B-O -assembly NOUN B-O -3.1 NUM B-O -) PUNCT B-O -resulted VERB B-O -into ADP B-O -an DET B-O -average NOUN B-O -of ADP B-O -22 NUM B-O -, PUNCT B-O -31.4 NUM B-O -, PUNCT B-O -and CCONJ B-O -34.6 NUM B-O -million NUM B-O -uniquely ADV B-O -mapped VERB B-O -reads NOUN B-O -for ADP B-O -extraembryonic ADJ B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -5 NUM B-O -) PUNCT B-O -, PUNCT B-O -caruncular ADJ B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -5 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -intercaruncular ADJ B-O -( PUNCT B-O -n NOUN B-O -= SYM B-O -5 NUM B-O -) PUNCT B-O -tissues NOUN B-O -, PUNCT B-O -respectively ADV B-O -. PUNCT B-O - -Hormone NOUN B-LF -therapy NOUN I-LF -( PUNCT B-O -HT PROPN B-AC -) PUNCT B-O -may AUX B-O -decrease VERB B-O -the DET B-O -risk NOUN B-O -of ADP B-O -osteoporosis NOUN B-O -and CCONJ B-O -bone NOUN B-O -fracture NOUN B-O -[ PUNCT B-O -31 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -review NOUN B-O -is AUX B-O -reported VERB B-O -according VERB B-O -to ADP B-O -the DET B-O -Preferred ADJ B-LF -Reporting PROPN I-LF -Items PROPN I-LF -for ADP I-LF -Systematic PROPN I-LF -Reviews PROPN I-LF -and CCONJ I-LF -Meta PROPN I-LF -- PROPN I-LF -Analyses PROPN I-LF -( PUNCT B-O -PRISMA PROPN B-AC -) PUNCT B-O -[ X B-O -19 X B-O -] PUNCT B-O -( PUNCT B-O -see VERB B-O -S1 PROPN B-O -Checklist PROPN B-O -) PUNCT B-O -and CCONJ B-O -the DET B-O -Guidelines PROPN B-O -for ADP B-O -Meta PROPN B-O -- PROPN B-O -Analyses PROPN B-O -and CCONJ B-O -Systematic PROPN B-O -Reviews PROPN B-O -of ADP B-O -Observational PROPN B-O -Studies.[20 PROPN B-O -] PUNCT B-O -The DET B-O -protocol NOUN B-O -was AUX B-O -published VERB B-O -in ADP B-O -advance NOUN B-O -( PUNCT B-O -ID NOUN B-O -= X B-O -CRD42015025488).[21 NUM B-O -] PUNCT B-O -Eligibility NOUN B-O -criteria NOUN B-O -were AUX B-O -defined VERB B-O -in ADP B-O -relation NOUN B-O -to ADP B-O -PICOS PROPN B-AC -( PUNCT B-O -participants NOUN B-LF -, PUNCT I-LF -interventions NOUN I-LF -, PUNCT I-LF -comparisons NOUN I-LF -, PUNCT I-LF -outcomes NOUN I-LF -, PUNCT I-LF -and CCONJ I-LF -study NOUN I-LF -design NOUN I-LF -) PUNCT B-O -as SCONJ B-O -recommended VERB B-O -by ADP B-O -PRISMA PROPN B-AC -. PUNCT B-O - -In ADP B-O -this DET B-O -study NOUN B-O -, PUNCT B-O -we PRON B-O -assembled VERB B-O -a DET B-O -large ADJ B-O -array NOUN B-O -of ADP B-O -variables NOUN B-O -from ADP B-O -4 NUM B-O -components NOUN B-O -within ADP B-O -HRS PROPN B-AC -, PUNCT B-O -including VERB B-O -the DET B-O -core NOUN B-O -survey NOUN B-O -( PUNCT B-O -1996–2016 NUM B-O -) PUNCT B-O -, PUNCT B-O -the DET B-O -newly ADV B-O -released VERB B-O -2015 NUM B-O -Life PROPN B-LF -History PROPN I-LF -Mail PROPN I-LF -Survey PROPN I-LF -( PUNCT B-O -LHMS PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -Enhanced PROPN B-LF -Face PROPN I-LF -- PUNCT I-LF -To ADP I-LF -- PUNCT I-LF -Face PROPN I-LF -( PUNCT B-O -EFTF PROPN B-AC -) PUNCT B-O -interview NOUN B-O -( PUNCT B-O -2006–2016 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -2016 NUM B-O -Venous PROPN B-LF -Blood PROPN I-LF -Study PROPN I-LF -( PUNCT B-O -VBS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -A DET B-O -description NOUN B-O -of ADP B-O -the DET B-O -4 NUM B-O -data NOUN B-O -sources NOUN B-O -can AUX B-O -be AUX B-O -found VERB B-O -in ADP B-O -S1 PROPN B-O -Appendix PROPN B-O -and CCONJ B-O -elsewhere ADV B-O -[ PUNCT B-O -31 NUM B-O -] PUNCT B-O -. PUNCT B-O - -A DET B-O -plot NOUN B-O -of ADP B-O -the DET B-O -total ADJ B-O -median ADJ B-LF -p-Stat5 PROPN B-AC -fluorescence NOUN I-LF -intensity NOUN I-LF -( PUNCT B-O -MFI PROPN B-AC -) PUNCT B-O -versus ADP B-O -Epo PROPN B-AC -concentration NOUN B-O -has VERB B-O -Michaelian ADJ B-O -kinetics NOUN B-O -with ADP B-O -a DET B-O -Hill PROPN B-LF -coefficient NOUN I-LF -( PUNCT B-O -nH PROPN B-AC -) PUNCT B-O -of ADP B-O -1 NUM B-O -( PUNCT B-O -lower ADJ B-O -left ADJ B-O -panel NOUN B-O -, PUNCT B-O -please INTJ B-O -note VERB B-O -a DET B-O -log NOUN B-O -scale NOUN B-O -was AUX B-O -used VERB B-O -for ADP B-O -the DET B-O -x NOUN B-O -- NOUN B-O -axis NOUN B-O -) PUNCT B-O -. PUNCT B-O - -A X B-O -: PUNCT B-O -Flow NOUN B-O -cytometry NOUN B-O -of ADP B-O -patient ADJ B-O -P3 NOUN B-O -peripheral ADJ B-LF -blood NOUN I-LF -mononuclear ADJ I-LF -cells NOUN I-LF -( PUNCT B-O -PBMC PROPN B-AC -) PUNCT B-O -( PUNCT B-O -left ADJ B-O -column NOUN B-O -) PUNCT B-O -followed VERB B-O -by ADP B-O -cell NOUN B-O -sorting NOUN B-O -of ADP B-O -TCRVβ22 NOUN B-O -+ ADJ B-O -tumor NOUN B-O -cells NOUN B-O -( PUNCT B-O -median ADJ B-O -column NOUN B-O -) PUNCT B-O -and CCONJ B-O -non ADJ B-O -- ADJ B-O -TCRVβ22 NOUN B-O -+ ADJ B-O -cells NOUN B-O -( PUNCT B-O -right ADJ B-O -column NOUN B-O -) PUNCT B-O -. PUNCT B-O - -STAT2 PROPN B-O -is AUX B-O -the DET B-O -quintessential ADJ B-O -transcription NOUN B-O -factor NOUN B-O -for ADP B-O -type NOUN B-O -1 NUM B-O -interferons NOUN B-LF -( PUNCT B-O -IFNs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -where SCONJ B-O -it PRON B-O -functions VERB B-O -as ADP B-O -a DET B-O -heterodimer NOUN B-O -with ADP B-O -STAT1 PROPN B-O -. PUNCT B-O - -However ADV B-O -, PUNCT B-O -the DET B-O -human ADJ B-O -and CCONJ B-O -murine ADJ B-O -STAT2 PROPN B-O -- PUNCT B-O -deficient ADJ B-O -phenotypes NOUN B-O -suggest VERB B-O -important ADJ B-O -additional ADJ B-O -and CCONJ B-O -currently ADV B-O -unidentified ADJ B-O -type NOUN B-O -1 NUM B-O -IFN PROPN B-AC -- PUNCT B-O -independent ADJ B-O -activities NOUN B-O -. PUNCT B-O - -We PRON B-O -performed VERB B-O -the DET B-O -present ADJ B-O -exclusive ADJ B-O -study NOUN B-O -to PART B-O -investigate VERB B-O -the DET B-O -associations NOUN B-O -between ADP B-O -a DET B-O -total NOUN B-O -of ADP B-O -9 NUM B-O -static ADJ B-O -and CCONJ B-O -14 NUM B-O -dynamic ADJ B-O -lactate NOUN B-O -indices NOUN B-O -during ADP B-O -the DET B-O -first ADJ B-O -24h NUM B-O -of ADP B-O -an DET B-O -intensive ADJ B-LF -care NOUN I-LF -unit NOUN I-LF -( PUNCT B-O -ICU PROPN B-AC -) PUNCT B-O -and CCONJ B-O -in ADP B-O -- PUNCT B-O -hospital NOUN B-O -mortality NOUN B-O -in ADP B-O -unselected ADJ B-O -ICU PROPN B-AC -patients NOUN B-O -. PUNCT B-O - -Since SCONJ B-O -selective ADJ B-O -serotonin NOUN B-O -reuptake NOUN B-O -inhibitors NOUN B-O -( PUNCT B-O -SSRIs PROPN B-O -) PUNCT B-O -such ADJ B-O -as ADP B-O -fluvoxamine NOUN B-O -and CCONJ B-O -sertraline NOUN B-O -are AUX B-O -potent ADJ B-O -σ1R NOUN B-O -ligands NOUN B-O -, PUNCT B-O -we PRON B-O -recently ADV B-O -focused VERB B-O -on ADP B-O -cardioprotective ADJ B-O -mechanisms NOUN B-O -of ADP B-O -SSRI PROPN B-O -through ADP B-O -the DET B-O -σ1R NOUN B-O -in ADP B-O -heart NOUN B-O -failure NOUN B-O -models NOUN B-O -using VERB B-O -transverse ADJ B-LF -aortic ADJ I-LF -constriction NOUN I-LF -( PUNCT B-O -TAC PROPN B-AC -) PUNCT B-O -mice NOUN B-O -and CCONJ B-O -ovariectomised ADJ B-O -rats NOUN B-O -[ PUNCT B-O -5–7 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Here ADV B-O -, PUNCT B-O -we PRON B-O -used VERB B-O -unilateral ADJ B-O -and CCONJ B-O -bilateral ADJ B-O -reversible ADJ B-O -inactivation NOUN B-O -of ADP B-O -the DET B-O -frontal ADJ B-LF -eye NOUN I-LF -fields NOUN I-LF -( PUNCT B-O -FEF PROPN B-AC -) PUNCT B-O -to PART B-O -identify VERB B-O -a DET B-O -cortical ADJ B-O -drive NOUN B-O -for ADP B-O -microsaccades NOUN B-O -. PUNCT B-O - -Ten NUM B-O -- PUNCT B-O -week NOUN B-O -- PUNCT B-O -old ADJ B-O -C57BL/6 PROPN B-O -male ADJ B-O -mice NOUN B-O -( PUNCT B-O -purchased VERB B-O -from ADP B-O -Taconic PROPN B-O -, PUNCT B-O -Ry PROPN B-O -, PUNCT B-O -Denmark PROPN B-O -, PUNCT B-O -and CCONJ B-O -allowed VERB B-O -one NUM B-O -week NOUN B-O -of ADP B-O -acclimatization NOUN B-O -on ADP B-O -chow NOUN B-O -diet NOUN B-O -before ADP B-O -study NOUN B-O -start NOUN B-O -) PUNCT B-O -were AUX B-O -fed VERB B-O -either CCONJ B-O -a DET B-O -high ADJ B-O -fat NOUN B-O -control NOUN B-O -diet NOUN B-O -( PUNCT B-O -HFD PROPN B-AC -, PUNCT B-O -n NOUN B-O -= SYM B-O -9 NUM B-O -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -a DET B-O -high ADJ B-LF -fat NOUN I-LF -diet NOUN I-LF -containing VERB B-O -0.75 NUM B-O -% NOUN B-O -TTA PROPN B-AC -( PUNCT B-O -n NOUN B-O -= SYM B-O -9 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -water NOUN B-O -ad X B-O -libitum X B-O -for ADP B-O -6 NUM B-O -weeks NOUN B-O -. PUNCT B-O - -Furthermore ADV B-O -, PUNCT B-O -rates NOUN B-O -of ADP B-O -new ADJ B-O -hepatitis NOUN B-LF -C PROPN I-LF -virus NOUN I-LF -( PUNCT B-O -HCV PROPN B-AC -) PUNCT B-O -infection NOUN B-O -are AUX B-O -on ADP B-O -the DET B-O -rise NOUN B-O -due ADP B-O -to ADP B-O -the DET B-O -ongoing ADJ B-O -epidemic NOUN B-O -of ADP B-O -injection NOUN B-O -drug NOUN B-O -use NOUN B-O -. PUNCT B-O - -It PRON B-O -was AUX B-O -found VERB B-O -that SCONJ B-O -an DET B-O -increase NOUN B-O -in ADP B-O -the DET B-O -optical ADJ B-LF -density NOUN I-LF -( PUNCT B-O -OD PROPN B-AC -) PUNCT B-O -of ADP B-O -the DET B-O -formazan NOUN B-O -dye NOUN B-O -directly ADV B-O -correlates VERB B-O -with ADP B-O -the DET B-O -metabolic ADJ B-O -activity NOUN B-O -of ADP B-O -the DET B-O -cells NOUN B-O -following VERB B-O -exposure NOUN B-O -to ADP B-O -either CCONJ B-O -Pt PROPN B-AC -or CCONJ B-O --DissPt PROPN B-AC -. PUNCT B-O - -For ADP B-O -measurement NOUN B-O -of ADP B-O -the DET B-O -formazan NOUN B-O -dye NOUN B-O -intensities NOUN B-O -, PUNCT B-O -the DET B-O -cell NOUN B-O -culture NOUN B-O -medium NOUN B-O -was AUX B-O -exchanged VERB B-O -with ADP B-O -those PRON B-O -containing VERB B-O -WST-1 NOUN B-O -solution NOUN B-O -at ADP B-O -the DET B-O -final ADJ B-O -concentration NOUN B-O -of ADP B-O -1 NUM B-O -mg NOUN B-O -/ SYM B-O -ml NOUN B-O -. PUNCT B-O - -Further ADV B-O -, PUNCT B-O -1,377 NUM B-O -of ADP B-O -these DET B-O -windows NOUN B-O -overlapped VERB B-O -with ADP B-O -the DET B-O -transcription NOUN B-O -start NOUN B-O -site NOUN B-O -or CCONJ B-O -gene NOUN B-O -body NOUN B-O -of ADP B-O -766 NUM B-O -independent ADJ B-O -genes NOUN B-O -in ADP B-O -Suz12 PROPN B-AC -- PUNCT B-O -deleted VERB B-O -basal ADJ B-O -organoids NOUN B-O -( PUNCT B-O -referred VERB B-O -to ADP B-O -as ADP B-O -differentially ADV B-LF -accessible ADJ I-LF -[ X B-O -DA PROPN B-AC -] X B-O -genes NOUN B-O -from ADP B-O -hereon ADV B-O -) PUNCT B-O -. PUNCT B-O - -Biopharmaceutical ADJ B-LF -products NOUN I-LF -( PUNCT B-O -BPs PROPN B-AC -) PUNCT B-O -are AUX B-O -widely ADV B-O -used VERB B-O -to PART B-O -treat VERB B-O -autoimmune ADJ B-O -diseases NOUN B-O -, PUNCT B-O -but CCONJ B-O -immunogenicity NOUN B-O -limits VERB B-O -their PRON B-O -efficacy NOUN B-O -for ADP B-O -an DET B-O -important ADJ B-O -proportion NOUN B-O -of ADP B-O -patients NOUN B-O -. PUNCT B-O - -ATc PROPN B-AC -, PUNCT B-O -anhydrotetracycline NOUN B-LF -; PUNCT B-O -GCaMP6 PROPN B-AC -, PUNCT B-O -GFP NOUN B-LF -- PUNCT I-LF -GFP PROPN B-AC -Calmodulin NOUN I-LF -- PUNCT I-LF -M13 NOUN I-LF -- PUNCT I-LF -peptide-6 NOUN I-LF -. PUNCT B-O - -To ADP B-O -this DET B-O -day NOUN B-O -, PUNCT B-O -vertebrate ADJ B-O -prion NOUN B-LF -proteins NOUN I-LF -exhibit VERB B-O -profound ADJ B-O -sequence NOUN B-O -similarities NOUN B-O -to ADP B-O -the DET B-O -subbranch NOUN B-O -of ADP B-O -ZIP PROPN B-O -zinc NOUN B-O -transporters NOUN B-O -comprising VERB B-O -ZIP5 NUM B-O -, PUNCT B-O -ZIP6 PROPN B-O -and CCONJ B-O -ZIP10 NOUN B-O -[ PUNCT B-O -2 NUM B-O -, PUNCT B-O -3 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -highly ADV B-O -similar ADJ B-O -defects NOUN B-O -in ADP B-O -the DET B-O -execution NOUN B-O -of ADP B-O -a DET B-O -morphogenetic ADJ B-O -program NOUN B-O -, PUNCT B-O -known VERB B-O -as ADP B-O -epithelial ADJ B-LF -- PUNCT I-LF -to ADP I-LF -- PUNCT I-LF -mesenchymal ADJ I-LF -transition NOUN I-LF -( PUNCT B-O -EMT PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -4 NUM B-O -] PUNCT B-O -, PUNCT B-O -have AUX B-O -been AUX B-O -reported VERB B-O -for ADP B-O -zebrafish NOUN B-O -embryos NOUN B-O -deficient ADJ B-O -in ADP B-O -ZIP6 PROPN B-O -[ PUNCT B-O -5 NUM B-O -] PUNCT B-O -or CCONJ B-O -PrP PROPN B-AC -[ PUNCT B-O -6 NUM B-O -] PUNCT B-O -. PUNCT B-O - -On ADP B-O -17 NUM B-O -days NOUN B-LF -of ADP I-LF -gestation NOUN I-LF -( PUNCT B-O -17-DG PROPN B-AC -) PUNCT B-O -, PUNCT B-O -the DET B-O -dams NOUN B-O -were AUX B-O -anesthetized VERB B-O -by ADP B-O -ketamine NOUN B-O -( PUNCT B-O -75mg NUM B-O -/ SYM B-O -kg NOUN B-O -) PUNCT B-O -and CCONJ B-O -xylazine NOUN B-O -( PUNCT B-O -10mg NUM B-O -/ SYM B-O -kg NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -uterus NOUN B-O -was AUX B-O -exposed VERB B-O -. PUNCT B-O - -All DET B-O -patients NOUN B-O -with ADP B-O -IVF PROPN B-AC -received VERB B-O -an DET B-O -implantable ADJ B-LF -cardioverter ADJ I-LF -defibrillator NOUN I-LF -( PUNCT B-O -ICD PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Patients NOUN B-O -took VERB B-O -oral ADJ B-O -antiarrhythmic ADJ B-O -agents NOUN B-O -during ADP B-O -the DET B-O -follow NOUN B-O -- ADJ B-O -up ADP B-O -period NOUN B-O -, PUNCT B-O -including VERB B-O -amiodarone NOUN B-O -, PUNCT B-O -flecainide NOUN B-O -, PUNCT B-O -propafenone NOUN B-O -, PUNCT B-O -beta NOUN B-O -- ADJ B-O -blockers NOUN B-O -( PUNCT B-O -BB PROPN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -calcium NOUN B-O -channel NOUN B-O -blocker NOUN B-O -( PUNCT B-O -CCB PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Many ADJ B-O -patients NOUN B-O -did AUX B-O -n’t PART B-O -take VERB B-O -medications NOUN B-O -and CCONJ B-O -the DET B-O -patients NOUN B-O -who PRON B-O -had AUX B-O -received VERB B-O -medication NOUN B-O -mostly ADV B-O -took VERB B-O -beta NOUN B-O -- ADJ B-O -blockers NOUN B-O -: PUNCT B-O -20 NUM B-O -patients NOUN B-O -in ADP B-O -the DET B-O -f PROPN B-AC -group NOUN B-O -[ PUNCT B-O -no DET B-O -medications NOUN B-O -( PUNCT B-O -7 NUM B-O -) PUNCT B-O -, PUNCT B-O -BB PROPN B-O -( PUNCT B-O -5 NUM B-O -) PUNCT B-O -, PUNCT B-O -CCB PROPN B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -, PUNCT B-O -amiodarone NOUN B-O -( PUNCT B-O -1 NUM B-O -) PUNCT B-O -, PUNCT B-O -CCB PROPN B-O -+ CCONJ B-O -BB PROPN B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -, PUNCT B-O -amiodarone NOUN B-O -+ CCONJ B-O -BB PROPN B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -flecanide NOUN B-O -+ CCONJ B-O -BB PROPN B-O -( PUNCT B-O -1 NUM B-O -) PUNCT B-O -] PUNCT B-O -, PUNCT B-O -35 NUM B-O -patients NOUN B-O -in ADP B-O -the DET B-O -J PROPN B-O -wave PROPN B-O -group NOUN B-O -[ PUNCT B-O -no DET B-O -medications NOUN B-O -( PUNCT B-O -15 NUM B-O -) PUNCT B-O -, PUNCT B-O -BB PROPN B-O -( PUNCT B-O -13 NUM B-O -) PUNCT B-O -, PUNCT B-O -CCB PROPN B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -, PUNCT B-O -amiodarone NOUN B-O -( PUNCT B-O -2 NUM B-O -) PUNCT B-O -, PUNCT B-O -CCB PROPN B-O -+ CCONJ B-O -BB PROPN B-O -( PUNCT B-O -1 NUM B-O -) PUNCT B-O -, PUNCT B-O -propafenone NOUN B-O -( PUNCT B-O -1 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -propafenone NOUN B-O -+ CCONJ B-O -BB PROPN B-O -( PUNCT B-O -1 NUM B-O -) PUNCT B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -26 NUM B-O -patients NOUN B-O -in ADP B-O -the DET B-O -normal ADJ B-O --QRSECG PROPN B-AC -group NOUN B-O -[ PUNCT B-O -no DET B-O -medications NOUN B-O -( PUNCT B-O -16 NUM B-O -) PUNCT B-O -, PUNCT B-O -BB PROPN B-O -( PUNCT B-O -9 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -amiodarone NOUN B-O -( PUNCT B-O -1 NUM B-O -) PUNCT B-O -] PUNCT B-O -. PUNCT B-O - -Although SCONJ B-O -adjuvant ADJ B-LF -platinum NOUN I-LF -- ADJ I-LF -based VERB I-LF -chemotherapy NOUN I-LF -( PUNCT B-O -AC PROPN B-AC -) PUNCT B-O -has AUX B-O -been AUX B-O -shown VERB B-O -to PART B-O -improve VERB B-O -survival NOUN B-O -of ADP B-O -patients NOUN B-O -with ADP B-O -completely ADV B-O -resected VERB B-O -stage NOUN B-O -II NUM B-O -and CCONJ B-O -stage NOUN B-O -IIIA NUM B-O -non ADJ B-LF -- ADJ I-LF -small ADJ I-LF -cell NOUN I-LF -lung NOUN I-LF -cancer NOUN I-LF -( PUNCT B-O -NSCLC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -its PRON B-O -effect NOUN B-O -is AUX B-O -limited ADJ B-O -. PUNCT B-O - -The DET B-O -DSX PROPN B-O -transgenic ADJ B-O -line NOUN B-O -[ X B-O -12 X B-O -] X B-O -that PRON B-O -expresses VERB B-O -GFP PROPN B-AC -( PUNCT B-O -green NOUN B-O -) PUNCT B-O -under ADP B-O -the DET B-O -β PUNCT B-O -- NOUN B-O -tubulin NOUN B-O -promoter NOUN B-O -in ADP B-O -the DET B-O -meiotic ADJ B-O -stages NOUN B-O -starting VERB B-O -from ADP B-O -spermatocytes NOUN B-O -but CCONJ B-O -not PART B-O -in ADP B-O -the DET B-O -mitotic ADJ B-O -germline NOUN B-LF -stem NOUN I-LF -cells NOUN I-LF -( PUNCT B-O -GSC PROPN B-AC -) PUNCT B-O -and CCONJ B-O -spermatogonia NOUN B-O -. PUNCT B-O - -MS PROPN B-AC -, PUNCT B-O -multiple ADJ B-LF -sclerosis NOUN I-LF -; PUNCT B-O -PMD PROPN B-AC -, PUNCT B-O -postmortem ADJ B-LF -delay NOUN I-LF -. PUNCT B-O - -A DET B-O -common ADJ B-O -limitation NOUN B-O -of ADP B-O -SE PROPN B-AC -recording NOUN B-O -is AUX B-O -the DET B-O -lack NOUN B-O -of ADP B-O -true ADJ B-O -monophasic ADJ B-O -shapes NOUN B-O -of ADP B-O -recorded VERB B-O -CAPs PROPN B-AC -due ADJ B-O -to ADP B-O -propagation NOUN B-O -of ADP B-O -action NOUN B-O -potentials NOUN B-O -within ADP B-O -the DET B-O -SE PROPN B-AC -portion NOUN B-O -of ADP B-O -axons NOUN B-O -, PUNCT B-O -resulting VERB B-O -in ADP B-O -different ADJ B-O -degrees NOUN B-O -of ADP B-O -biphasicity NOUN B-O -depending VERB B-O -on ADP B-O -preservation NOUN B-O -of ADP B-O -conduction NOUN B-O -properties NOUN B-O -of ADP B-O -distinct ADJ B-O -types NOUN B-O -of ADP B-O -axons NOUN B-O -within ADP B-O -the DET B-O -SE PROPN B-AC -. PUNCT B-O - -As ADP B-O -in ADP B-O -any DET B-O -SE PROPN B-AC -- PUNCT B-O -recorded VERB B-O -CAPs PROPN B-AC -, PUNCT B-O -the DET B-O -signals NOUN B-O -propagating VERB B-O -within ADP B-O -the DET B-O -suction NOUN B-LF -electrode NOUN I-LF -portion NOUN B-O -of ADP B-O -axons NOUN B-O -may AUX B-O -create VERB B-O -a DET B-O -time NOUN B-O -- PUNCT B-O -shifted VERB B-O -signal NOUN B-O -of ADP B-O -opposite ADJ B-O -polarity NOUN B-O -affecting VERB B-O -the DET B-O -peaks NOUN B-O -and CCONJ B-O -valleys NOUN B-O -of ADP B-O -recorded VERB B-O -signals NOUN B-O -, PUNCT B-O -being AUX B-O -more ADV B-O -pronounced ADJ B-O -in ADP B-O -slower ADV B-O -conducting VERB B-O -components NOUN B-O -( PUNCT B-O -seen VERB B-O -to ADP B-O -different ADJ B-O -extent NOUN B-O -in ADP B-O -Figs NOUN B-O -2–9 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Healthcare NOUN B-LF -- PUNCT I-LF -associated VERB I-LF -infections NOUN I-LF -( PUNCT B-O -HAIs PROPN B-AC -) PUNCT B-O -are AUX B-O -associated VERB B-O -with ADP B-O -increased VERB B-O -morbidity NOUN B-O -and CCONJ B-O -mortality NOUN B-O -and CCONJ B-O -excess ADJ B-O -costs NOUN B-O -, PUNCT B-O -and CCONJ B-O -because SCONJ B-O -a DET B-O -significant ADJ B-O -proportion NOUN B-O -of ADP B-O -them PRON B-O -are AUX B-O -preventable ADJ B-O -, PUNCT B-O -they PRON B-O -are AUX B-O -considered VERB B-O -to PART B-O -be AUX B-O -a DET B-O -marker NOUN B-O -of ADP B-O -quality NOUN B-O -of ADP B-O -patient NOUN B-O -care NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Randomised ADJ B-LF -controlled VERB I-LF -trials NOUN I-LF -( PUNCT B-O -RCTs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -longitudinal ADJ B-O -cohort NOUN B-O -, PUNCT B-O -and CCONJ B-O -cross ADJ B-O -- ADJ B-O -sectional ADJ B-O -studies NOUN B-O -were AUX B-O -considered VERB B-O -for ADP B-O -inclusion NOUN B-O -, PUNCT B-O -whereas SCONJ B-O -retrospective ADJ B-O -registry NOUN B-O -reviews NOUN B-O -, PUNCT B-O -medical ADJ B-O -records NOUN B-O -audits NOUN B-O -, PUNCT B-O -and CCONJ B-O -qualitative ADJ B-O -studies NOUN B-O -were AUX B-O -excluded VERB B-O -. PUNCT B-O - -These DET B-O -results NOUN B-O -are AUX B-O -not PART B-O -from ADP B-O -data NOUN B-O -collected VERB B-O -in ADP B-O -a DET B-O -centralised ADJ B-O -laboratory NOUN B-O -, PUNCT B-O -and CCONJ B-O -different ADJ B-O -multiplex NOUN B-O -polymerase NOUN B-LF -chain NOUN I-LF -reaction NOUN I-LF -( PUNCT B-O -PCR PROPN B-AC -) PUNCT B-O -panels NOUN B-O -for ADP B-O -detecting VERB B-O -viruses NOUN B-O -were AUX B-O -used VERB B-O -in ADP B-O -the DET B-O -respective ADJ B-O -laboratories NOUN B-O -[ PUNCT B-O -19 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Open ADJ B-LF -access NOUN I-LF -( PUNCT B-O -OA PROPN B-AC -) PUNCT B-O -to ADP B-O -the DET B-O -scientific ADJ B-O -literature NOUN B-O -means VERB B-O -the DET B-O -removal NOUN B-O -of ADP B-O -barriers NOUN B-O -( PUNCT B-O -including VERB B-O -price NOUN B-O -barriers NOUN B-O -) PUNCT B-O -from ADP B-O -accessing VERB B-O -scholarly ADJ B-O -work NOUN B-O -. PUNCT B-O - -f X B-O -- X B-O -forward NOUN B-O -; PUNCT B-O -r NOUN B-O -- X B-O -reverse NOUN B-O -; PUNCT B-O -Ta NOUN B-O -– PUNCT B-O -Annealing NOUN B-O -temperature NOUN B-O -, PUNCT B-O -RE- NOUN B-O -restriction NOUN B-O -Enzyme PROPN B-O -, PUNCT B-O -AS PROPN B-AC -- X B-O -Allele PROPN B-LF -Specific PROPN I-LF -Ref PROPN B-O -- X B-O -reference NOUN B-O -We PRON B-O -also ADV B-O -collected VERB B-O -measures NOUN B-O -of ADP B-O -inhibitory ADJ B-O -control NOUN B-O -and CCONJ B-O -working VERB B-O -memory NOUN B-O -using VERB B-O -the DET B-O -pencil NOUN B-LF -tapping NOUN I-LF -task NOUN I-LF -( PUNCT B-O -PTT PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -29 X B-O -] PUNCT B-O -and CCONJ B-O -of ADP B-O -pre ADJ B-O -- PUNCT B-O -academic ADJ B-O -skills NOUN B-O -using VERB B-O -a DET B-O -subset NOUN B-O -of ADP B-O -age NOUN B-O -- PUNCT B-O -appropriate ADJ B-O -items NOUN B-O -from ADP B-O -the DET B-O -Daberon PROPN B-LF -Screening PROPN I-LF -for ADP I-LF -School PROPN I-LF -Readiness PROPN I-LF -– PUNCT I-LF -Second PROPN I-LF -Edition PROPN I-LF -( PUNCT B-O -Daberon-2 PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -30 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Acute ADJ B-LF -respiratory ADJ I-LF -infection NOUN I-LF -( PUNCT B-O -ARI PROPN B-AC -) PUNCT B-O -and CCONJ B-O -diarrhoea NOUN B-O -are AUX B-O -the DET B-O -leading VERB B-O -causes NOUN B-O -of ADP B-O -childhood NOUN B-O -morbidity NOUN B-O -and CCONJ B-O -mortality NOUN B-O -in ADP B-O -Ethiopia PROPN B-O -. PUNCT B-O - -Clinical ADJ B-O -outcomes NOUN B-O -and CCONJ B-O -the DET B-O -proportion NOUN B-O -of ADP B-O -justified ADJ B-O -use NOUN B-O -of ADP B-O -personal ADJ B-O -nursing NOUN B-O -care NOUN B-O -were AUX B-O -evaluated VERB B-O -using VERB B-O -a DET B-O -statistical ADJ B-O -technique NOUN B-O -known VERB B-O -as ADP B-O -Generalized PROPN B-LF -Pairwise PROPN I-LF -Comparisons PROPN I-LF -( PUNCT B-O -GPC PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -46 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Within ADP B-O -the DET B-O -control NOUN B-O -group NOUN B-O -CRMP-5 PROPN B-AC -was AUX B-O -verified VERB B-O -with ADP B-O -a DET B-O -label NOUN B-LF -- PUNCT I-LF -free ADJ I-LF -quantification NOUN I-LF -intensity NOUN I-LF -( PUNCT B-O -LFQI PROPN B-AC -) PUNCT B-O -of ADP B-O -1.93x109 NUM B-O -. PUNCT B-O - -Notably ADV B-O -, PUNCT B-O -although SCONJ B-O -it PRON B-O -has AUX B-O -previously ADV B-O -been AUX B-O -hypothesized VERB B-O -that SCONJ B-O -the DET B-O -hormonal ADJ B-O -drivers NOUN B-O -of ADP B-O -PD PROPN B-AC -would AUX B-O -result VERB B-O -in ADP B-O -it PRON B-O -being AUX B-O -a DET B-O -stronger ADJ B-O -risk NOUN B-O -marker NOUN B-O -for ADP B-O -oestrogen NOUN B-LF -receptor NOUN I-LF -( PUNCT B-O -ER)–positive PROPN B-AC -than ADP B-O -ER PROPN B-AC -- PUNCT B-O -negative ADJ B-O -breast NOUN B-O -cancer NOUN B-O -, PUNCT B-O -a DET B-O -large ADJ B-O -differential NOUN B-O -in ADP B-O -the DET B-O -MD PROPN B-AC -- PUNCT B-O -breast NOUN B-O -cancer NOUN B-O -association NOUN B-O -by ADP B-O -tumour NOUN B-O -subtype NOUN B-O -does AUX B-O -not PART B-O -appear VERB B-O -to PART B-O -be AUX B-O -present ADJ B-O -[ PUNCT B-O -23 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Interleukins NOUN B-LF -( PUNCT B-O -ILs PROPN B-AC -) PUNCT B-O -are AUX B-O -a DET B-O -group NOUN B-O -of ADP B-O -cytokines NOUN B-O -that PRON B-O -are AUX B-O -involved VERB B-O -in ADP B-O -the DET B-O -communication NOUN B-O -between ADP B-O -immune ADJ B-O -and CCONJ B-O -inflammatory ADJ B-O -cells NOUN B-O -, PUNCT B-O -and CCONJ B-O -38 NUM B-O -ILs PROPN B-AC -have AUX B-O -been AUX B-O -identified VERB B-O -thus ADV B-O -far ADV B-O -. PUNCT B-O - -There PRON B-O -are VERB B-O -different ADJ B-O -types NOUN B-O -of ADP B-O -medication NOUN B-O -reviews NOUN B-O -, PUNCT B-O -ranging VERB B-O -from ADP B-O -a DET B-O -prescription NOUN B-O -review NOUN B-O -( PUNCT B-O -which PRON B-O -is AUX B-O -basically ADV B-O -an DET B-O -evaluation NOUN B-O -of ADP B-O -the DET B-O -list NOUN B-O -of ADP B-O -prescribed VERB B-O -medicines NOUN B-O -) PUNCT B-O -to ADP B-O -a DET B-O -clinical ADJ B-LF -medication NOUN I-LF -review NOUN I-LF -( PUNCT B-O -CMR PROPN B-AC -; PUNCT B-O -with ADP B-O -the DET B-O -availability NOUN B-O -of ADP B-O -all DET B-O -clinical ADJ B-O -data NOUN B-O -and CCONJ B-O -an DET B-O -extensive ADJ B-O -patient NOUN B-O -interview NOUN B-O -) PUNCT B-O -[ PUNCT B-O -3 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Sural ADJ B-LF -sensory ADJ I-LF -nerve NOUN I-LF -amplitude NOUN I-LF -( PUNCT B-O -SSNamp PROPN B-AC -) PUNCT B-O -, PUNCT B-O -sural ADJ B-LF -sensory ADJ I-LF -nerve NOUN I-LF -conduction NOUN I-LF -velocity NOUN I-LF -( PUNCT B-O -SSNCV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -peroneal ADJ B-LF -motor NOUN I-LF -nerve NOUN I-LF -amplitude NOUN I-LF -( PUNCT B-O -PMNamp PROPN B-AC -) PUNCT B-O -and CCONJ B-O -peroneal ADJ B-LF -motor NOUN I-LF -nerve NOUN I-LF -conduction NOUN I-LF -velocity NOUN I-LF -( PUNCT B-O -PMNCV PROPN B-AC -) PUNCT B-O -were AUX B-O -assessed VERB B-O -using VERB B-O -a DET B-O -Dantec PROPN B-O -“ PUNCT B-O -Keypoint PROPN B-O -” PUNCT B-O -system NOUN B-O -( PUNCT B-O -Dantec PROPN B-O -Dynamics PROPN B-O -Ltd PROPN B-O -, PUNCT B-O -Bristol PROPN B-O -, PUNCT B-O -UK PROPN B-O -) PUNCT B-O -. PUNCT B-O - -DF PROPN B-AC -, PUNCT B-O -dorsal ADJ B-LF -funiculus NOUN I-LF -; PUNCT B-O -dVL PROPN B-AC -, PUNCT B-O -dorsal ADJ B-LF -ventricular ADJ I-LF -layer NOUN I-LF -; PUNCT B-O -NKX6.1 NOUN B-O -, PUNCT B-O -NK6 NOUN B-O -homeobox NOUN B-O -1 NUM B-O -; PUNCT B-O -SOX2 PROPN B-O -, PUNCT B-O -SRY NOUN B-O -- PUNCT B-O -related VERB B-O -HMG NOUN B-O -- PUNCT B-O -box NOUN B-O -2 NUM B-O -; PUNCT B-O -VF PROPN B-AC -, PUNCT B-O -ventral ADJ B-LF -funiculus NOUN I-LF -; PUNCT B-O -VL PROPN B-AC -, PUNCT B-O -ventricular ADJ B-LF -layer NOUN I-LF -; PUNCT B-O -vVL PROPN B-AC -, PUNCT B-O -ventral ADJ B-LF -ventricular ADJ B-LF -layer NOUN I-LF -; PUNCT B-O -( PUNCT B-O -+ PUNCT B-O -) PUNCT B-O -, PUNCT B-O -expressing NOUN B-O -. PUNCT B-O - -Powers PROPN B-O -et PROPN B-O -al NOUN B-O -. PUNCT B-O - -estimated VERB B-O -that SCONJ B-O -the DET B-O -fraction NOUN B-LF -of ADP I-LF -HIV PROPN I-LF -incidence NOUN I-LF -attributable ADJ I-LF -to PART I-LF -transmission NOUN I-LF -from ADP I-LF -acutely ADV I-LF -infected VERB I-LF -individuals NOUN I-LF -( PUNCT B-O -AFacute PROPN B-AC -) PUNCT B-O -was AUX B-O -40 NUM B-O -% NOUN B-O -[ PUNCT B-O -19 NUM B-O -] PUNCT B-O -, PUNCT B-O -while SCONJ B-O -Williams PROPN B-O -et PROPN B-O -al NOUN B-O -. PUNCT B-O - -argued VERB B-O -that SCONJ B-O -AFacute PROPN B-AC -was AUX B-O -more ADV B-O -likely ADJ B-O -to PART B-O -be AUX B-O -2%–4 NUM B-O -% NOUN B-O -[ PUNCT B-O -44 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Is AUX B-O -six NUM B-LF -- PUNCT I-LF -minute NOUN I-LF -- PUNCT I-LF -walk NOUN I-LF -distance NOUN I-LF -" PUNCT B-O -6MWD PROPN B-AC -” PUNCT B-O -? PUNCT B-O -Is AUX B-O -six NUM B-LF -- PUNCT I-LF -minute NOUN I-LF -- PUNCT I-LF -walk NOUN I-LF -test NOUN I-LF -" PUNCT B-O -6MWT PROPN B-AC -” PUNCT B-O -? PUNCT B-O -( PUNCT B-O -Line NOUN B-O -55 NUM B-O -) PUNCT B-O -Response NOUN B-O -: PUNCT B-O -We PRON B-O -have AUX B-O -revised VERB B-O -the DET B-O -abbreviations NOUN B-O -in ADP B-O -the DET B-O -manuscript NOUN B-O -. PUNCT B-O - -The DET B-O -primary ADJ B-O -trial NOUN B-O -outcome NOUN B-O -was AUX B-O -a DET B-O -composite ADJ B-O -endpoint NOUN B-O -of ADP B-O -women NOUN B-O -’s PART B-O -retention NOUN B-O -in ADP B-O -ART PROPN B-AC -care NOUN B-O -and CCONJ B-O -viral ADJ B-LF -suppression NOUN I-LF -( PUNCT B-O -VS PROPN B-AC -) PUNCT B-O -( PUNCT B-O -viral ADJ B-O -load NOUN B-O -< ADP B-O -50 NUM B-O -copies NOUN B-O -/ SYM B-O -ml NOUN B-O -) PUNCT B-O -at ADP B-O -12 NUM B-O -months NOUN B-O -postpartum ADV B-O -; PUNCT B-O -secondary ADJ B-O -outcomes NOUN B-O -included VERB B-O -duration NOUN B-O -of ADP B-O -any PRON B-O -and CCONJ B-O -exclusive ADJ B-O -breastfeeding NOUN B-O -, PUNCT B-O -mother NOUN B-O -- PUNCT B-O -to ADP B-O -- PUNCT B-O -child NOUN B-O -HIV PROPN B-O -transmission NOUN B-O -, PUNCT B-O -and CCONJ B-O -infant NOUN B-O -mortality NOUN B-O -. PUNCT B-O - -The DET B-O -MSIS-29 PROPN B-AC -consists VERB B-O -of ADP B-O -29 NUM B-O -questions NOUN B-O -answered VERB B-O -on ADP B-O -a DET B-O -5 NUM B-O -- PUNCT B-O -point NOUN B-O -Likert PROPN B-O -scale NOUN B-O -, PUNCT B-O -giving VERB B-O -2 NUM B-O -scores NOUN B-O -: PUNCT B-O -the DET B-O -MSIS-29 PROPN B-LF -physical ADJ I-LF -MSIS-29 PROPN B-AC -( PUNCT B-O -MSIS-29 PROPN B-AC -) PUNCT B-O -score NOUN B-O -( PUNCT B-O -questions NOUN B-O -1–20 NUM B-O -; PUNCT B-O -therefore ADV B-O -score NOUN B-O -range NOUN B-O -20–100 NUM B-O -) PUNCT B-O -and CCONJ B-O -the DET B-O -MSIS-29 PROPN B-LF -psychological ADJ I-LF --PHYSMSIS-29 PROPN B-AC -( PUNCT B-O -MSIS-29 PROPN B-AC -) PUNCT B-O -score NOUN B-O -( PUNCT B-O -questions NOUN B-O -21–29 NUM B-O -; PUNCT B-O -therefore ADV B-O -score NOUN B-O -range NOUN B-O -9–45 NUM B-O -) PUNCT B-O -[ PUNCT B-O -14,26 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Metabolic ADJ B-LF -syndrome NOUN I-LF -( PUNCT B-O -MetS PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -cluster NOUN B-O -of ADP B-O -risk NOUN B-O -factors NOUN B-O -that PRON B-O -encompasses VERB B-O -metabolic ADJ B-O -, PUNCT B-O -vascular ADJ B-O -, PUNCT B-O -and CCONJ B-O -inflammatory ADJ B-O -indicators NOUN B-O -. PUNCT B-O - -Portal ADJ B-LF -Venous ADJ I-LF -Thrombosis NOUN I-LF -( PUNCT B-O -PVT PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -common ADJ B-O -complication NOUN B-O -of ADP B-O -Hepatocellular ADJ B-LF -Carcinoma PROPN I-LF -( PUNCT B-O -HCC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -assessed VERB B-O -as ADP B-O -adverse ADJ B-O -prognostic ADJ B-O -factor NOUN B-O -and CCONJ B-O -parameter NOUN B-O -of ADP B-O -tumor NOUN B-O -aggressiveness NOUN B-O -together ADV B-O -with ADP B-O -tumor NOUN B-O -size NOUN B-O -, PUNCT B-O -multifocality NOUN B-O -and CCONJ B-O -Alpha NOUN B-LF -- PUNCT I-LF -fetoprotein NOUN I-LF -( PUNCT B-O -AFP PROPN B-AC -) PUNCT B-O -levels NOUN B-O -[ PUNCT B-O -1,2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -These DET B-O -estimates NOUN B-O -do AUX B-O -not PART B-O -account VERB B-O -for ADP B-O -immunity NOUN B-O -resulting VERB B-O -from ADP B-O -transmission NOUN B-O -of ADP B-O -OPV PROPN B-AC -among ADP B-O -contacts NOUN B-O -of ADP B-O -vaccinated VERB B-O -children NOUN B-O -, PUNCT B-O -maternally ADV B-O -derived VERB B-O -antibodies NOUN B-O -, PUNCT B-O -or CCONJ B-O -naturally ADV B-O -acquired VERB B-O -immunity NOUN B-O -following VERB B-O -exposure NOUN B-O -to ADP B-O -cVDPV2 PROPN B-AC -. PUNCT B-O - -In ADP B-O -Nigeria PROPN B-O -, PUNCT B-O -receipt NOUN B-O -of ADP B-O -tOPV PROPN B-AC -through ADP B-O -RI PROPN B-AC -was AUX B-O -inferred VERB B-O -from ADP B-O -district NOUN B-O -- PUNCT B-O -level NOUN B-O -coverage NOUN B-O -with ADP B-O -three NUM B-O -doses NOUN B-O -of ADP B-O -diphtheria NOUN B-O -- PUNCT B-O -tetanus NOUN B-O -- PUNCT B-O -pertussis NOUN B-O -( PUNCT B-O -DTP3 PROPN B-O -) PUNCT B-O -vaccine NOUN B-O -at ADP B-O -the DET B-O -age NOUN B-O -of ADP B-O -12 NUM B-O -mo NOUN B-O -or CCONJ B-O -later ADV B-O -estimated VERB B-O -from ADP B-O -Demographic PROPN B-LF -and CCONJ I-LF -Health PROPN I-LF -Surveys PROPN I-LF -( PUNCT B-O -DHS PROPN B-AC -) PUNCT B-O -data NOUN B-O -( PUNCT B-O -estimates NOUN B-O -are AUX B-O -derived VERB B-O -in ADP B-O -[ PUNCT B-O -22 NUM B-O -] PUNCT B-O -) PUNCT B-O -. PUNCT B-O - -Coxsackievirus PROPN B-LF -B PROPN I-LF -( PUNCT B-O -CVB PROPN B-AC -) PUNCT B-O -belongs VERB B-O -to ADP B-O -the DET B-O -Enterovirus NOUN B-O -B PROPN B-O -species NOUN B-O -of ADP B-O -the DET B-O -Picornaviridae PROPN B-O -family NOUN B-O -and CCONJ B-O -has AUX B-O -been AUX B-O -associated VERB B-O -with ADP B-O -a DET B-O -wide ADJ B-O -range NOUN B-O -of ADP B-O -diseases NOUN B-O -from ADP B-O -mild ADJ B-O -respiratory ADJ B-O -infections NOUN B-O -to ADP B-O -more ADV B-O -severe ADJ B-O -infections NOUN B-O -of ADP B-O -the DET B-O -central ADJ B-O -nervous ADJ B-O -system NOUN B-O -, PUNCT B-O -heart NOUN B-O -and CCONJ B-O -pancreas NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -order NOUN B-O -to PART B-O -systematically ADV B-O -investigate VERB B-O -the DET B-O -influence NOUN B-O -of ADP B-O -potentially ADV B-O -functional ADJ B-O -coding VERB B-O -polymorphisms NOUN B-O -in ADP B-O -the DET B-O -NLR PROPN B-O -genes NOUN B-O -on ADP B-O -sporadic ADJ B-O -CRC PROPN B-AC -risk NOUN B-O -and CCONJ B-O -survival NOUN B-O -, PUNCT B-O -we PRON B-O -conducted VERB B-O -a DET B-O -case NOUN B-O -- ADJ B-O -control NOUN B-O -study NOUN B-O -with ADP B-O -replications NOUN B-O -in ADP B-O -2 NUM B-O -large ADJ B-O -genome NOUN B-O -- ADJ B-O -wide ADJ B-O -association NOUN B-O -studies NOUN B-O -( PUNCT B-O -GWASs PROPN B-O -) PUNCT B-O -, PUNCT B-O -covering VERB B-O -the DET B-O -majority NOUN B-O -of ADP B-O -known VERB B-O -non ADJ B-LF -- ADJ I-LF -synonymous ADJ I-LF -single ADJ I-LF -nucleotide NOUN I-LF -polymorphisms NOUN I-LF -( PUNCT B-O -nsSNPs PROPN B-AC -) PUNCT B-O -in ADP B-O -21 NUM B-O -genes NOUN B-O -across ADP B-O -different ADJ B-O -NLR PROPN B-O -signalling NOUN B-O -pathways NOUN B-O -. PUNCT B-O - -Progress NOUN B-LF -variables NOUN I-LF -( PUNCT B-O -PVs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -akin ADJ B-O -to ADP B-O -reaction NOUN B-O -coordinates NOUN B-O -, PUNCT B-O -for ADP B-O -all DET B-O -free ADJ B-O -- PUNCT B-O -energy NOUN B-O -molecular ADJ B-O -dynamics NOUN B-O -calculations NOUN B-O -were AUX B-O -chosen VERB B-O -as ADP B-O -the DET B-O -location NOUN B-O -on ADP B-O -the DET B-O -z NOUN B-O -axis NOUN B-O -of ADP B-O -the DET B-O -center NOUN B-O -of ADP B-O -mass NOUN B-O -of ADP B-O -the DET B-O -small ADJ B-O -- PUNCT B-O -molecule(s NOUN B-O -) PUNCT B-O -of ADP B-O -interest NOUN B-O -. PUNCT B-O - -Non ADJ B-LF -- ADJ I-LF -alcoholic ADJ I-LF -fatty ADJ I-LF -liver NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -NAFLD PROPN B-AC -) PUNCT B-O -is AUX B-O -defined VERB B-O -as ADP B-O -the DET B-O -accumulation NOUN B-O -of ADP B-O -excess ADJ B-O -, PUNCT B-O -microscopically ADV B-O -visible ADJ B-O -lipid NOUN B-O -in ADP B-O -hepatocytes NOUN B-O -in ADP B-O -the DET B-O -absence NOUN B-O -of ADP B-O -excessive ADJ B-O -alcohol NOUN B-O -consumption NOUN B-O -and CCONJ B-O -is AUX B-O -now ADV B-O -the DET B-O -most ADV B-O -common ADJ B-O -chronic ADJ B-O -liver NOUN B-O -disease NOUN B-O -in ADP B-O -developed VERB B-O -countries NOUN B-O -[ PUNCT B-O -1 NUM B-O -, PUNCT B-O -2 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -current ADJ B-O -prequalified ADJ B-O -oral ADJ B-LF -cholera NOUN I-LF -vaccines NOUN I-LF -( PUNCT B-O -OCVs PROPN B-AC -) PUNCT B-O -provide VERB B-O -over ADP B-O -80 NUM B-O -% NOUN B-O -( PUNCT B-O -direct ADJ B-O -) PUNCT B-O -protection NOUN B-O -in ADP B-O -the DET B-O -first ADJ B-O -6 NUM B-O -mo NOUN B-O -after ADP B-O -vaccination NOUN B-O -[ PUNCT B-O -2–4 NUM B-O -] PUNCT B-O -, PUNCT B-O -with ADP B-O -protection NOUN B-O -of ADP B-O -up ADP B-O -to PART B-O -65 NUM B-O -% NOUN B-O -for ADP B-O -5 NUM B-O -y NOUN B-O -estimated VERB B-O -in ADP B-O -an DET B-O -endemic ADJ B-O -setting NOUN B-O -[ PUNCT B-O -5 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -volatile ADJ B-LF -fatty ADJ I-LF -acids NOUN I-LF -( PUNCT B-O -VFAs PROPN B-AC -) PUNCT B-O -in ADP B-O -HARs PROPN B-AC -and CCONJ B-O -BRs PROPN B-AC -were AUX B-O -measured VERB B-O -acetic ADJ B-O -, PUNCT B-O -propionate NOUN B-O -, PUNCT B-O -iso ADJ B-O -- PUNCT B-O -butyric ADJ B-O -, PUNCT B-O -butyric ADJ B-O -, PUNCT B-O -valeric ADJ B-O -and CCONJ B-O -iso ADJ B-O -- PUNCT B-O -valeric ADJ B-O -acid NOUN B-O -by ADP B-O -GC PROPN B-O -( PUNCT B-O -GC-2001 PROPN B-O -, PUNCT B-O -Shimadzu PROPN B-O -, PUNCT B-O -Japan PROPN B-O -) PUNCT B-O -equipped VERB B-O -with ADP B-O -hydrogen NOUN B-O -flame NOUN B-O -ionization NOUN B-O -detector NOUN B-O -( PUNCT B-O -FID PROPN B-O -) PUNCT B-O -using VERB B-O -Nitrogen PROPN B-O -as ADP B-O -a DET B-O -carrier NOUN B-O -gas NOUN B-O -in ADP B-O -a DET B-O -quartz NOUN B-O -capillary NOUN B-O -column NOUN B-O -( PUNCT B-O -30 NUM B-O -m×0.32 NUM B-O -mm×D×0.25 NUM B-O -μm NOUN B-O -; PUNCT B-O -Stabilwax PROPN B-O -- PUNCT B-O -DA PROPN B-O -, PUNCT B-O -RESTEK PROPN B-O -, PUNCT B-O -USA PROPN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -GC PROPN B-O -was AUX B-O -operated VERB B-O -when SCONJ B-O -the DET B-O -injection NOUN B-O -port NOUN B-O -and CCONJ B-O -detector NOUN B-O -temperatures NOUN B-O -were AUX B-O -220 NUM B-O -° NUM B-O -C NOUN B-O -and CCONJ B-O -230 NUM B-O -° NUM B-O -C NOUN B-O -, PUNCT B-O -respectively ADV B-O -. PUNCT B-O - -Concurrently ADV B-O -, PUNCT B-O -Ca2 NOUN B-O -+ NOUN B-O -binding VERB B-O -to ADP B-O -another DET B-O -synaptic ADJ B-O -vesicle NOUN B-O -associated VERB B-O -protein NOUN B-O -, PUNCT B-O -Synaptotagmin PROPN B-LF -1 NUM I-LF -( PUNCT B-O -Syt1 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -triggers VERB B-O -the DET B-O -migration NOUN B-O -of ADP B-O -synaptic ADJ B-O -vesicles NOUN B-O -towards ADP B-O -the DET B-O -plasma NOUN B-O -membrane NOUN B-O -, PUNCT B-O -with ADP B-O -Syt1 PROPN B-AC -mediating VERB B-O -the DET B-O -docking NOUN B-O -, PUNCT B-O -fusion NOUN B-O -and CCONJ B-O -exocytosis NOUN B-O -of ADP B-O -the DET B-O -readily ADV B-O -releasable ADJ B-O -synaptic ADJ B-O -vesicles NOUN B-O -at ADP B-O -the DET B-O -synaptic ADJ B-O -cleft NOUN B-O -[ PUNCT B-O -30–32 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Light NOUN B-O -induced VERB B-O -c NOUN B-O -- PUNCT B-O -Fos NOUN B-O -immunoreactivity NOUN B-O -in ADP B-O -the DET B-O -suprachiasmatic ADJ B-O -nuclei NOUN B-O -( PUNCT B-O -SCN PROPN B-AC -) PUNCT B-O -and CCONJ B-O -in ADP B-O -sleep NOUN B-O -- PUNCT B-O -active ADJ B-O -ventrolateral ADJ B-LF -preoptic ADJ I-LF -( PUNCT B-O -VLPO PROPN B-AC -) PUNCT B-O -neurons NOUN B-O -was AUX B-O -importantly ADV B-O -reduced VERB B-O -in ADP B-O -Opn4−/− PROPN B-O -mice NOUN B-O -, PUNCT B-O -implicating VERB B-O -both DET B-O -sleep NOUN B-O -- PUNCT B-O -regulatory ADJ B-O -structures NOUN B-O -in ADP B-O -the DET B-O -melanopsin NOUN B-O -- PUNCT B-O -mediated VERB B-O -effects NOUN B-O -of ADP B-O -light NOUN B-O -. PUNCT B-O - -SDS PROPN B-O -- ADJ B-O -PAGE PROPN B-O -under ADP B-O -reducing VERB B-O -conditions NOUN B-O -of ADP B-O -antithrombin ADJ B-O -in ADP B-O -complex NOUN B-O -with ADP B-O -FXa PROPN B-O -upon SCONJ B-O -activation NOUN B-O -with ADP B-O -low ADJ B-LF -molecular ADJ I-LF -weight NOUN I-LF -heparin NOUN I-LF -( PUNCT B-O -LMWH PROPN B-AC -) PUNCT B-O -, PUNCT B-O -active ADJ B-O -heparanase NOUN B-O -( PUNCT B-O -HPSE PROPN B-O -) PUNCT B-O -, PUNCT B-O -10 NUM B-O -- ADJ B-O -fold ADJ B-O -concentrated ADJ B-O -medium NOUN B-O -of ADP B-O -cells NOUN B-O -transfected VERB B-O -with ADP B-O -proheparanase NOUN B-O -( PUNCT B-O -mProHPSE PROPN B-O -) PUNCT B-O -; PUNCT B-O -10 NUM B-O -- ADJ B-O -fold ADJ B-O -concentrated ADJ B-O -medium NOUN B-O -of ADP B-O -cells NOUN B-O -transfected VERB B-O -with ADP B-O -an DET B-O -empty ADJ B-O -plasmid NOUN B-O -but CCONJ B-O -supplemented VERB B-O -with ADP B-O -active ADJ B-O -heparanase NOUN B-O -( PUNCT B-O -mHPSE PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Detection NOUN B-O -was AUX B-O -done VERB B-O -by ADP B-O -western ADJ B-O -blot NOUN B-O -using VERB B-O -an DET B-O -anti ADJ B-O -- ADJ B-O -antithrombin ADJ B-O -antibody NOUN B-O -. PUNCT B-O - -Treating VERB B-O -hyperglycemia NOUN B-O -in ADP B-O -previously ADV B-O -non ADJ B-O -- PUNCT B-O -diabetic ADJ B-O -individuals NOUN B-O -with ADP B-O -exogenous ADJ B-O -insulin NOUN B-O -immediately ADV B-O -after ADP B-O -kidney NOUN B-O -transplantation NOUN B-O -reduced VERB B-O -the DET B-O -odds NOUN B-O -of ADP B-O -developing VERB B-O -Posttransplantation PROPN B-LF -Diabetes PROPN I-LF -Mellitus PROPN I-LF -( PUNCT B-O -PTDM PROPN B-AC -) PUNCT B-O -in ADP B-O -our PRON B-O -previous ADJ B-O -proof NOUN B-O -- PUNCT B-O -of ADP B-O -- PUNCT B-O -concept NOUN B-O -clinical ADJ B-O -trial NOUN B-O -. PUNCT B-O - -Our PRON B-O -dataset NOUN B-O -comprised VERB B-O -40 NUM B-O -acylcarnitines NOUN B-O -, PUNCT B-O -34 NUM B-O -lipids NOUN B-O -( PUNCT B-O -14 NUM B-O -lysophospholipids NOUN B-O -, PUNCT B-O -10 NUM B-O -sphingolipids NOUN B-O -, PUNCT B-O -and CCONJ B-O -10 NUM B-O -phosphatidylcholines NOUN B-O -) PUNCT B-O -, PUNCT B-O -24 NUM B-O -amino ADJ B-O -acids NOUN B-O -, PUNCT B-O -16 NUM B-O -organic ADJ B-O -acids NOUN B-O -, PUNCT B-O -12 NUM B-O -biogenic ADJ B-O -amines NOUN B-O -, PUNCT B-O -and CCONJ B-O -4 NUM B-O -metabolites NOUN B-O -classified VERB B-O -as ADP B-O -‘ PUNCT B-O -other ADJ B-O -’ PUNCT B-O -( PUNCT B-O -creatine NOUN B-O -, PUNCT B-O -choline NOUN B-O -, PUNCT B-O -trimethylamine NOUN B-LF -N NOUN I-LF -- PUNCT I-LF -oxide NOUN I-LF -[ PUNCT B-O -TMAO PROPN B-AC -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -glucose NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Brazil PROPN B-O -’s PART B-O -considerable ADJ B-O -investments NOUN B-O -in ADP B-O -social ADJ B-O -protection NOUN B-O -policies NOUN B-O -over ADP B-O -the DET B-O -last ADJ B-O -two NUM B-O -decades NOUN B-O -include VERB B-O -the DET B-O -rollout NOUN B-O -of ADP B-O -conditional ADJ B-O -cash NOUN B-O -transfers NOUN B-O -under ADP B-O -the DET B-O -Bolsa PROPN B-O -Família PROPN B-O -programme NOUN B-O -and CCONJ B-O -a DET B-O -commitment NOUN B-O -to ADP B-O -UHC PROPN B-AC -with ADP B-O -the DET B-O -expansion NOUN B-O -of ADP B-O -PHC PROPN B-AC -through ADP B-O -the DET B-O -Estratégia PROPN B-LF -de ADP I-LF -Saúde PROPN I-LF -da PROPN I-LF -Família PROPN I-LF -( PUNCT B-O -ESF PROPN B-AC -) PUNCT B-O -( PUNCT B-O -family NOUN B-O -health NOUN B-O -strategy NOUN B-O -) PUNCT B-O -[ PUNCT B-O -14,15 NUM B-O -] PUNCT B-O -. PUNCT B-O - -For ADP B-O -comparison NOUN B-O -to ADP B-O -the DET B-O -Global PROPN B-LF -Lipids PROPN I-LF -Genetics PROPN I-LF -Consortium PROPN I-LF -( PUNCT B-O -GLGC PROPN B-AC -) PUNCT B-O -lipid NOUN B-O -panel NOUN B-O -and CCONJ B-O -extension NOUN B-O -to ADP B-O -other ADJ B-O -lipoproteins NOUN B-O -, PUNCT B-O -we PRON B-O -also ADV B-O -included VERB B-O -the DET B-O -2019 NUM B-O -release NOUN B-O -of ADP B-O -the DET B-O -Neale PROPN B-O -Lab PROPN B-O -UKB PROPN B-AC -GWAS PROPN B-AC -( PUNCT B-O -automated ADJ B-O -diastolic ADJ B-O -and CCONJ B-O -systolic ADJ B-O -blood NOUN B-LF -pressure NOUN I-LF -( PUNCT B-O -BP PROPN B-AC -) PUNCT B-O -measurement NOUN B-O -) PUNCT B-O -and CCONJ B-O -their PRON B-O -biochemistry NOUN B-O -panel NOUN B-O -( PUNCT B-O -HDL PROPN B-AC -, PUNCT B-O --CLDL PROPN B-AC -direct ADJ B-O -, PUNCT B-O --CTRG PROPN B-AC -, PUNCT B-O -apolipoprotein NOUN B-LF -A NOUN I-LF -( PUNCT B-O -ApoA PROPN B-AC -) PUNCT B-O -, PUNCT B-O -ApoB PROPN B-AC -, PUNCT B-O -and CCONJ B-O -lipoprotein NOUN B-O -A NOUN B-O -) PUNCT B-O -[ PUNCT B-O -36 NUM B-O -] PUNCT B-O -. PUNCT B-O - -CH PROPN B-AC -, PUNCT B-O -chronic ADJ B-LF -hepatitis NOUN I-LF -; PUNCT B-O -LC PROPN B-AC -, PUNCT B-O -liver NOUN B-O -cirrhotic ADJ B-O -; PUNCT B-O -HCC PROPN B-AC -, PUNCT B-O -hepatocellular ADJ B-LF -carcinoma NOUN I-LF -; PUNCT B-O -SNP PROPN B-AC -, PUNCT B-O -single ADJ B-LF -nucleotide NOUN I-LF -polymorphism NOUN I-LF -; PUNCT B-O -HWE PROPN B-AC -, PUNCT B-O -Hardy PROPN B-LF -- PUNCT I-LF -Weinberg PROPN I-LF -Equilibrium PROPN I-LF -; PUNCT B-O -Del PROPN B-O -, PUNCT B-O -deletion NOUN B-O -; PUNCT B-O -ID NOUN B-O -, PUNCT B-O -insertion NOUN B-O -+ SYM B-O -deletion NOUN B-O -; PUNCT B-O -Ht PROPN B-AC -, PUNCT B-O -haplotype NOUN B-LF -. PUNCT B-O - -Foam NOUN B-O -cell NOUN B-O -formation NOUN B-O -is AUX B-O -regulated VERB B-O -by ADP B-O -several ADJ B-O -factors NOUN B-O -: NOUN B-O -1 NUM B-O -) PUNCT B-O -scavenger NOUN B-O -receptors NOUN B-O -, PUNCT B-O -such ADJ B-O -as ADP B-O -CD36 PROPN B-AC -and CCONJ B-O -lectin NOUN B-O -- NOUN B-O -like ADJ B-O -ox- NOUN B-O -low ADJ B-LF -- NOUN I-LF -density NOUN I-LF -lipoprotein NOUN I-LF -( PUNCT B-O -LDL PROPN B-AC -) PUNCT B-O -receptor-1 NOUN B-O -( PUNCT B-O -Lox-1 PROPN B-AC -) PUNCT B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -, PUNCT B-O -2 X B-O -) PUNCT B-O -acyl NOUN B-O -- NOUN B-O -coenzyme NOUN B-O -A NOUN B-O -: NOUN B-O -cholesterol NOUN B-O -acyltransferase NOUN B-O -1 NUM B-O -( PUNCT B-O -ACAT1 PROPN B-O -) PUNCT B-O -, PUNCT B-O -a DET B-O -rate NOUN B-O -- NOUN B-O -limiting VERB B-O -enzyme NOUN B-O -for ADP B-O -the DET B-O -esterification NOUN B-O -of ADP B-O -cholesterol NOUN B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -3 X B-O -) PUNCT B-O -free ADJ B-O -- NOUN B-O -cholesterol NOUN B-O -efflux NOUN B-O -mediated VERB B-O -by ADP B-O -ATP PROPN B-O -- NOUN B-O -binding VERB B-O -cassette NOUN B-O -transporter NOUN B-O -A1 NOUN B-O -( PUNCT B-O -ABCA1 PROPN B-O -) PUNCT B-O -and CCONJ B-O -ATP PROPN B-O -- NOUN B-O -binding VERB B-O -cassette NOUN B-O -sub NOUN B-O -- NOUN B-O -family NOUN B-O -G NOUN B-O -member NOUN B-O -1 NUM B-O -( PUNCT B-O -ABCG1 PROPN B-O -) PUNCT B-O -[ PUNCT B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Events NOUN B-O -corresponding VERB B-O -to PART B-O -γδ PUNCT B-O -T NOUN B-O -( PUNCT B-O -green ADJ B-O -) PUNCT B-O -, PUNCT B-O -invariant ADJ B-O -natural ADJ B-O -killer NOUN B-O -T NOUN B-O -( PUNCT B-O -iNKT PROPN B-AC -) PUNCT B-O -( PUNCT B-O -red ADJ B-O -) PUNCT B-O -, PUNCT B-O -MAIT PROPN B-AC -( PUNCT B-O -blue ADJ B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -conventional ADJ B-O -T NOUN B-O -( PUNCT B-O -Tconv PROPN B-AC -) PUNCT B-O -( PUNCT B-O -cyan NOUN B-O -) PUNCT B-O -cells NOUN B-O -were AUX B-O -superimposed VERB B-O -to PART B-O -generate VERB B-O -a DET B-O -dot NOUN B-O -plot NOUN B-O -( PUNCT B-O -B NOUN B-O -) PUNCT B-O -. PUNCT B-O - -The DET B-O -frequency NOUN B-O -of ADP B-O -IFN PROPN B-AC -- NOUN B-O -γ+ NOUN B-O -cells NOUN B-O -and CCONJ B-O -the DET B-O -mean ADJ B-LF -fluorescence NOUN I-LF -intensity NOUN I-LF -( PUNCT B-O -MFI PROPN B-AC -) PUNCT B-O -of ADP B-O -IFN PROPN B-AC -- NOUN B-O -γ PUNCT B-O -staining NOUN B-O -were AUX B-O -determined VERB B-O -in ADP B-O -7 NUM B-O -donors NOUN B-O -, PUNCT B-O -each PRON B-O -of ADP B-O -whom PRON B-O -is AUX B-O -represented VERB B-O -by ADP B-O -a DET B-O -circle NOUN B-O -( PUNCT B-O -C NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Five NUM B-O -subpopulations NOUN B-O -were AUX B-O -defined VERB B-O -among ADP B-O -SEB PROPN B-AC -- NOUN B-O -stimulated VERB B-O -CD3 NOUN B-O -+ NOUN B-O -cells NOUN B-O -based VERB B-O -on ADP B-O -their PRON B-O -co NOUN B-O -- NOUN B-O -expression NOUN B-O -of ADP B-O -CD161 NOUN B-O -and CCONJ B-O -Vα7.2 NOUN B-O -, PUNCT B-O -or CCONJ B-O -lack NOUN B-O -thereof ADV B-O -. PUNCT B-O - -Receiver NOUN B-O -- PUNCT B-O -operating VERB B-O -characteristic ADJ B-O -( PUNCT B-O -ROC PROPN B-AC -) PUNCT B-O -curves NOUN B-O -were AUX B-O -constructed VERB B-O -to PART B-O -calculate VERB B-O -the DET B-O -best ADJ B-O -cutoff NOUN B-O -values NOUN B-O -, PUNCT B-O -including VERB B-O -the DET B-O -area NOUN B-O -under ADP B-O -the DET B-O -curve NOUN B-O -( PUNCT B-O -AUC PROPN B-AC -) PUNCT B-O -, PUNCT B-O -positive ADJ B-LF -predictive ADJ I-LF -value NOUN I-LF -( PUNCT B-O -PPV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -negative ADJ B-LF -predictive ADJ I-LF -value NOUN I-LF -( PUNCT B-O -NPV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -accuracy NOUN B-O -for ADP B-O -discriminating VERB B-O -H. NOUN B-O -pylori NOUN B-O -positivity NOUN B-O -, PUNCT B-O -chronic ADJ B-O -gastritis NOUN B-O -, PUNCT B-O -and CCONJ B-O -atrophic ADJ B-O -gastritis NOUN B-O -. PUNCT B-O - -To ADP B-O -that DET B-O -end NOUN B-O -, PUNCT B-O -the DET B-LF -Cancer PROPN I-LF -Genome PROPN I-LF -Atlas PROPN I-LF -( PUNCT B-O -TCGA PROPN B-AC -) PUNCT B-O -was AUX B-O -used VERB B-O -to PART B-O -identify VERB B-O -samples NOUN B-O -from ADP B-O -LUSC PROPN B-AC -( PUNCT B-O -lung ADJ B-LF -squamous ADJ I-LF -cell NOUN I-LF -carcinoma NOUN I-LF -) PUNCT B-O -and CCONJ B-O -LUAC PROPN B-AC -( PUNCT B-O -lung ADJ B-LF -adenocarcinoma NOUN I-LF -) PUNCT B-O -patients NOUN B-O -for ADP B-O -which PRON B-O -clinical ADJ B-O -follow VERB B-O -- PUNCT B-O -up ADP B-O -data NOUN B-O -was AUX B-O -available ADJ B-O -. PUNCT B-O - -STROBE PROPN B-AC -, PUNCT B-O -Strengthening VERB B-LF -the DET I-LF -Reporting NOUN I-LF -of ADP I-LF -Observational ADJ I-LF -Studies NOUN I-LF -in ADP I-LF -Epidemiology NOUN I-LF -. PUNCT B-O - -All DET B-O -these DET B-O -13 NUM B-O -genes NOUN B-O -are AUX B-O -co ADJ B-O -- ADJ B-O -DE PROPN B-AC -in ADP B-O -acute ADJ B-LF -megakaryoblastic ADJ I-LF -leukemia NOUN I-LF -( PUNCT B-O -AMKL PROPN B-AC -) PUNCT B-O -and CCONJ B-O -acute ADJ B-LF -myeloid ADJ I-LF -leukemia NOUN I-LF -( PUNCT B-O -AML PROPN B-AC -) PUNCT B-O -mononuclear ADJ B-O -cells NOUN B-O -. PUNCT B-O - -Gi PROPN B-AC -, PUNCT B-O -nucleus NOUN B-LF -gigantocellularis NOUN I-LF -; PUNCT B-O -DR PROPN B-AC -, PUNCT B-O -dorsal ADJ B-LF -raphé NOUN I-LF -; PUNCT B-O -LC PROPN B-AC -, PUNCT B-O -locus NOUN B-LF -coeruleus NOUN I-LF -; PUNCT B-O -LDT PROPN B-AC -, PUNCT B-O -laterodorsal ADJ B-LF -tegmental ADJ I-LF -nucleus NOUN I-LF -; PUNCT B-O -PC PROPN B-AC -, PUNCT B-O -nucleus NOUN B-LF -pontis NOUN I-LF -caudalis NOUN I-LF -; PUNCT B-O -PO PROPN B-AC -, PUNCT B-O -nucleus NOUN B-LF -pontis NOUN I-LF -oralis ADJ I-LF -; PUNCT B-O -SubLC PROPN B-AC -, PUNCT B-O -subcoeruleus NOUN B-LF -PM2.5 PROPN B-AC -, PUNCT B-O -particulate NOUN B-LF -matter NOUN I-LF -with ADP I-LF -an DET I-LF -aerodynamic ADJ I-LF -diameter NOUN I-LF -less ADJ I-LF -than ADP I-LF -or CCONJ I-LF -equal ADJ I-LF -to ADP I-LF -2.5 NUM I-LF -μm NOUN I-LF -or CCONJ I-LF -fine ADJ I-LF -particulate NOUN I-LF -matter NOUN I-LF -; PUNCT B-O -YLL PROPN B-AC -, PUNCT B-O -years NOUN B-LF -of ADP I-LF -life NOUN I-LF -lost VERB I-LF -. PUNCT B-O - -Inflammation NOUN B-O -is AUX B-O -an DET B-O -important ADJ B-O -factor NOUN B-O -in ADP B-O -the DET B-O -pathogenesis NOUN B-O -of ADP B-O -calcific ADJ B-O -aortic ADJ B-LF -stenosis NOUN I-LF -( PUNCT B-O -AS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -We PRON B-O -aimed VERB B-O -to ADP B-O -evaluate VERB B-O -the DET B-O -association NOUN B-O -between ADP B-O -an DET B-O -inflammatory ADJ B-O -marker NOUN B-O -, PUNCT B-O -neutrophil NOUN B-LF -- PUNCT I-LF -to ADP I-LF -- PUNCT I-LF -lymphocyte NOUN I-LF -ratio NOUN I-LF -( PUNCT B-O -NLR PROPN B-AC -) PUNCT B-O -and CCONJ B-O -major ADJ B-LF -adverse ADJ I-LF -cardiovascular ADJ I-LF -events NOUN I-LF -( PUNCT B-O -MACE PROPN B-AC -) PUNCT B-O -in ADP B-O -patients NOUN B-O -with ADP B-O -severe ADJ B-O -calcific ADJ B-O -AS PROPN B-AC -. PUNCT B-O - -Nuclei NOUN B-O -were AUX B-O -stained VERB B-O -by ADP B-O -4',6 NUM B-LF -- PUNCT I-LF -diamidino-2 NOUN I-LF -- PUNCT I-LF -phenylindole NOUN I-LF -( PUNCT B-O -DAPI PROPN B-AC -) PUNCT B-O -( PUNCT B-O -Sigma PROPN B-O -- PUNCT B-O -Aldrich PROPN B-O -, PUNCT B-O -Lyon PROPN B-O -, PUNCT B-O -France PROPN B-O -) PUNCT B-O -, PUNCT B-O -used VERB B-O -at ADP B-O -a DET B-O -1:2000 NUM B-O -dilution NOUN B-O -in ADP B-O -Mowiol PROPN B-O -mounting NOUN B-O -medium NOUN B-O -( PUNCT B-O -2.4 NUM B-O -g NOUN B-O -Mowiol PROPN B-O -4–88 NUM B-O -from ADP B-O -Sigma PROPN B-O -- PUNCT B-O -Aldrich PROPN B-O -, PUNCT B-O -6 NUM B-O -g NOUN B-O -glycerol NOUN B-O -, PUNCT B-O -6 NUM B-O -mL NOUN B-O -distilled VERB B-O -water NOUN B-O -, PUNCT B-O -12 NUM B-O -mL NOUN B-O -0.2 NUM B-O -M NOUN B-O -Tris NOUN B-O -- PUNCT B-O -Cl NOUN B-O -buffer NOUN B-O -· PUNCT B-O -pH NOUN B-O -8.5 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Here ADV B-O -, PUNCT B-O -we PRON B-O -use VERB B-O -cryo NOUN B-LF -- PUNCT I-LF -electron NOUN I-LF -microscopy NOUN I-LF -( PUNCT B-O -cryoEM PROPN B-AC -) PUNCT B-O -to ADP B-O -decipher VERB B-O -the DET B-O -mechanism NOUN B-O -of ADP B-O -action NOUN B-O -of ADP B-O -a DET B-O -potent ADJ B-O -HA PROPN B-AC -head NOUN B-O -- PUNCT B-O -directed VERB B-O -monoclonal ADJ B-LF -antibody NOUN I-LF -( PUNCT B-O -mAb PROPN B-AC -) PUNCT B-O -bound VERB B-O -to ADP B-O -an DET B-O -influenza NOUN B-O -H7 PROPN B-O -HA PROPN B-AC -. PUNCT B-O - -The DET B-O -epitope NOUN B-O -of ADP B-O -the DET B-O -antibody NOUN B-O -is AUX B-O -not PART B-O -solvent NOUN B-O -accessible ADJ B-O -in ADP B-O -the DET B-O -compact ADJ B-O -, PUNCT B-O -prefusion NOUN B-O -conformation NOUN B-O -that PRON B-O -typifies VERB B-O -all DET B-O -HA PROPN B-AC -structures NOUN B-O -to ADP B-O -date NOUN B-O -. PUNCT B-O - -Matrix NOUN B-LF -effects NOUN I-LF -( PUNCT B-O -ME PROPN B-AC -) PUNCT B-O -, PUNCT B-O -extraction NOUN B-O -recoveries NOUN B-O -( PUNCT B-O -ER PROPN B-AC -) PUNCT B-O -and CCONJ B-O -process NOUN B-O -efficiencies NOUN B-O -( PUNCT B-O -PE PROPN B-AC -) PUNCT B-O -for ADP B-O -PBTZ169 PROPN B-O -, PUNCT B-O -five NUM B-O -active ADJ B-O -metabolites NOUN B-O -and CCONJ B-O -internal ADJ B-O -standards NOUN B-O -were AUX B-O -quantitatively ADV B-O -assessed VERB B-O -according VERB B-O -to ADP B-O -Matuszeswski PROPN B-O -’s PART B-O -procedures NOUN B-O -as ADP B-O -well ADV B-O -as ADP B-O -to ADP B-O -the DET B-O -recommendations NOUN B-O -of ADP B-O -the DET B-O -EMEA PROPN B-AC -/ SYM B-O -FDA PROPN B-AC -[ X B-O -27 NUM B-O -, PUNCT B-O -28 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Among ADP B-O -these DET B-O -measures NOUN B-O -are AUX B-O -years NOUN B-O -of ADP B-O -life NOUN B-O -lost VERB B-O -( PUNCT B-O -YLLs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -quantifies VERB B-O -the DET B-O -number NOUN B-O -of ADP B-O -years NOUN B-O -of ADP B-O -life NOUN B-O -lost VERB B-O -because SCONJ B-O -the DET B-O -person NOUN B-O -dies VERB B-O -prematurely ADV B-O -due ADP B-O -to ADP B-O -a DET B-O -disease NOUN B-O -or CCONJ B-O -injury NOUN B-O -; PUNCT B-O -years NOUN B-O -lived VERB B-O -with ADP B-O -disability NOUN B-O -( PUNCT B-O -YLDs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -quantifies VERB B-O -the DET B-O -healthy ADJ B-O -time NOUN B-O -lost VERB B-O -by ADP B-O -a DET B-O -person NOUN B-O -living VERB B-O -with ADP B-O -a DET B-O -disability NOUN B-O -caused VERB B-O -by ADP B-O -a DET B-O -disease NOUN B-O -or CCONJ B-O -injury NOUN B-O -; PUNCT B-O -and CCONJ B-O -disability NOUN B-LF -- PUNCT I-LF -adjusted VERB I-LF -life NOUN I-LF -years NOUN I-LF -( PUNCT B-O -DALYs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -a DET B-O -summary NOUN B-O -measure NOUN B-O -that PRON B-O -is AUX B-O -the DET B-O -sum NOUN B-O -of ADP B-O -YLLs PROPN B-AC -and CCONJ B-O -YLDs PROPN B-AC -[ PUNCT B-O -17 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Irrespective ADV B-O -of ADP B-O -familial ADJ B-O -relationship NOUN B-O -, PUNCT B-O -adults NOUN B-O -who PRON B-O -resided VERB B-O -with ADP B-O -another DET B-O -adult NOUN B-O -with ADP B-O -any DET B-O -chronic ADJ B-O -condition NOUN B-O -had VERB B-O -29 NUM B-O -% NOUN B-O -higher ADJ B-O -adjusted ADJ B-O -relative ADJ B-O -odds NOUN B-O -of ADP B-O -having VERB B-O -1 NUM B-O -or CCONJ B-O -more ADJ B-O -chronic ADJ B-O -conditions NOUN B-O -themselves PRON B-O -( PUNCT B-O -adjusted ADJ B-LF -odds NOUN I-LF -ratio NOUN I-LF -[ X B-O -aOR PROPN B-AC -] X B-O -= SYM B-O -1.29 NUM B-O -; PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval NOUN I-LF -[ X B-O -95 NUM B-O -% NOUN B-O -CI PROPN B-AC -] X B-O -1.10–1.50 NUM B-O -) PUNCT B-O -. PUNCT B-O - -LJD PROPN B-O -was AUX B-O -the DET B-O -Chairman PROPN B-O -of ADP B-O -the DET B-O -National PROPN B-O -Patient PROPN B-O -Safety PROPN B-O -Agency PROPN B-O -( PUNCT B-O -NPSA PROPN B-O -) PUNCT B-O -( PUNCT B-O -2010–2012 NUM B-O -) PUNCT B-O -and CCONJ B-O -is AUX B-O -currently ADV B-O -involved ADJ B-O -in ADP B-O -the DET B-O -programme NOUN B-O -of ADP B-O -research NOUN B-O -associated VERB B-O -with ADP B-O -the DET B-O -National PROPN B-LF -Reporting PROPN I-LF -and CCONJ I-LF -Learning PROPN I-LF -System PROPN I-LF -( PUNCT B-O -NRLS PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -He PRON B-O -is AUX B-O -also ADV B-O -the DET B-O -World PROPN B-O -Health PROPN B-O -Organization PROPN B-O -'s PART B-O -Patient PROPN B-O -Safety PROPN B-O -Envoy PROPN B-O -. PUNCT B-O - -Many ADJ B-O -additional ADJ B-O -milestones NOUN B-O -have AUX B-O -been AUX B-O -reached VERB B-O -, PUNCT B-O -including VERB B-O -the DET B-O -last ADJ B-O -naturally ADV B-O -occurring VERB B-O -isolation NOUN B-O -of ADP B-O -serotype-2 NOUN B-O -WPV PROPN B-AC -in ADP B-O -1999 NUM B-O -, PUNCT B-O -the DET B-O -last ADJ B-O -reported VERB B-O -case NOUN B-O -of ADP B-O -poliomyelitis NOUN B-O -associated VERB B-O -with ADP B-O -serotype-3 NOUN B-O -in ADP B-O -2012 NUM B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -absence NOUN B-O -of ADP B-O -any DET B-O -reported VERB B-O -wild ADJ B-LF -poliovirus NOUN I-LF -type NOUN I-LF -1 NUM I-LF -( PUNCT B-O -WPV1 PROPN B-AC -) PUNCT B-O -cases NOUN B-O -in ADP B-O -Africa PROPN B-O -outside ADP B-O -of ADP B-O -Borno PROPN B-O -, PUNCT B-O -Nigeria PROPN B-O -( PUNCT B-O -which PRON B-O -reported VERB B-O -4 NUM B-O -WPV1 PROPN B-AC -cases NOUN B-O -with ADP B-O -a DET B-O -date NOUN B-O -of ADP B-O -onset NOUN B-O -in ADP B-O -July PROPN B-O -– PUNCT B-O -August PROPN B-O -2016 NUM B-O -and CCONJ B-O -remains VERB B-O -a DET B-O -challenge NOUN B-O -because SCONJ B-O -of ADP B-O -issues NOUN B-O -with ADP B-O -security NOUN B-O -, PUNCT B-O -inaccessibility NOUN B-O -, PUNCT B-O -and CCONJ B-O -weak ADJ B-O -surveillance NOUN B-O -) PUNCT B-O -, PUNCT B-O -since SCONJ B-O -August PROPN B-O -2014 NUM B-O -( PUNCT B-O -in ADP B-O -Somalia PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Ex ADJ B-LF -- ADJ I-LF -vivo ADJ I-LF -lung NOUN I-LF -perfusion NOUN I-LF -( PUNCT B-O -EVLP PROPN B-AC -) PUNCT B-O -is AUX B-O -an DET B-O -emerging VERB B-O -technique NOUN B-O -promising VERB B-O -an DET B-O -expansion NOUN B-O -of ADP B-O -the DET B-O -donor NOUN B-O -pool NOUN B-O -and CCONJ B-O -improvements NOUN B-O -in ADP B-O -the DET B-O -outcome NOUN B-O -after ADP B-O -lung NOUN B-O -transplantation NOUN B-O -. PUNCT B-O - -These DET B-O -results NOUN B-O -contrast VERB B-O -to ADP B-O -the DET B-O -prevalent ADJ B-O -thought NOUN B-O -that SCONJ B-O -oxygen NOUN B-O -- PUNCT B-O -reactive ADJ B-O -Hbs PROPN B-AC -( PUNCT B-O -HbII NOUN B-O -and CCONJ B-O -HbIII NOUN B-O -) PUNCT B-O -are AUX B-O -widely ADV B-O -distributed VERB B-O -and CCONJ B-O -that SCONJ B-O -the DET B-O -sulfide NOUN B-O -- PUNCT B-O -reactive ADJ B-O -hemoglobin NOUN B-LF -( PUNCT B-O -HbI NOUN B-O -) PUNCT B-O -is AUX B-O -only ADV B-O -present ADJ B-O -in ADP B-O -the DET B-O -tissue NOUN B-O -where SCONJ B-O -the DET B-O -endosymbiont NOUN B-O -is AUX B-O -located VERB B-O -[ X B-O -1 NUM B-O -] PUNCT B-O -. PUNCT B-O - -CTRL PROPN B-O -, PUNCT B-O -control NOUN B-O -; PUNCT B-O -EXC PROPN B-O -, PUNCT B-O -excised VERB B-O -; PUNCT B-O -hpi PROPN B-O -, PUNCT B-O -hours NOUN B-O -post NOUN B-O -invasion NOUN B-O -; PUNCT B-O -INT PROPN B-O -, PUNCT B-O -integration NOUN B-O -; PUNCT B-O -n.s PROPN B-O -. PUNCT B-O - -, PUNCT B-O -not PART B-O -significant ADJ B-O -by ADP B-O -unpaired ADJ B-O -t NOUN B-O -test NOUN B-O -( PUNCT B-O -p NOUN B-O -- PUNCT B-O -value NOUN B-O -= SYM B-O -0.9895 NUM B-O -) PUNCT B-O -; PUNCT B-O -PDEβ PROPN B-AC -, PUNCT B-O -phosphodiesterase NOUN B-LF -β PUNCT I-LF -; PUNCT B-O -PfPDEβ PROPN B-AC -, PUNCT B-O -Plasmodium NOUN B-LF -falciparum NOUN I-LF -phosphodiesterase NOUN B-LF -β PUNCT I-LF -; PUNCT B-O -RAP PROPN B-AC -, PUNCT B-O -rapamycin NOUN B-LF -; PUNCT B-O -RFU PROPN B-O -, PUNCT B-O -relative ADJ B-O -fluorescence NOUN B-O -unit NOUN B-O -. PUNCT B-O - -Additionally ADV B-O -, PUNCT B-O -participants NOUN B-O -reported VERB B-O -that SCONJ B-O -most ADJ B-O -of ADP B-O -the DET B-O -current ADJ B-O -priority NOUN B-O -initiatives NOUN B-O -such ADJ B-O -as ADP B-O -Clean PROPN B-LF -and CCONJ I-LF -Safe PROPN I-LF -Health PROPN I-LF -Facility PROPN I-LF -( PUNCT B-O -CASH PROPN B-AC -) PUNCT B-O -, PUNCT B-O -quality NOUN B-O -movement NOUN B-O -, PUNCT B-O -and CCONJ B-O -Compassionate PROPN B-LF -, PUNCT I-LF -Respectful PROPN I-LF -, PUNCT I-LF -and CCONJ I-LF -Caring PROPN I-LF -( PUNCT B-O -CRC PROPN B-AC -) PUNCT B-O -by ADP B-O -the DET B-O -Federal PROPN B-O -Minstry PROPN B-O -of ADP B-O -Health PROPN B-O -( PUNCT B-O -FMOH PROPN B-O -) PUNCT B-O -could AUX B-O -well ADV B-O -be AUX B-O -complemented VERB B-O -by ADP B-O -the DET B-O -intents NOUN B-O -of ADP B-O -the DET B-O -current ADJ B-O -guideline NOUN B-O -. PUNCT B-O - -These DET B-O -cases NOUN B-O -have AUX B-O -deserved VERB B-O -the DET B-O -designation NOUN B-O -of ADP B-O -GT PROPN B-AC -- PUNCT B-O -like ADJ B-O -syndrome NOUN B-O -( PUNCT B-O -GTLS PROPN B-AC -) PUNCT B-O -or CCONJ B-O -ITGA2B PROPN B-LF -/ SYM I-LF -ITGA2B PROPN B-AC -ITGB3 PROPN I-LF -- PUNCT I-LF -ITGB3 PROPN B-AC -related VERB I-LF -thrombocytopenia NOUN I-LF -( PUNCT B-O -ITGA2B PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -The DET B-O -first ADJ B-O -description NOUN B-O -dates VERB B-O -to ADP B-O -the DET B-O -1990s NOUN B-O -[ PUNCT B-O -14,15 NUM B-O -] PUNCT B-O -, PUNCT B-O -and CCONJ B-O -, PUNCT B-O -along ADP B-O -the DET B-O -recent ADJ B-O -years NOUN B-O -, PUNCT B-O -the DET B-O -disease NOUN B-O -has AUX B-O -been AUX B-O -characterized VERB B-O -, PUNCT B-O -with ADP B-O -only ADV B-O -a DET B-O -few ADJ B-O -variants NOUN B-O -being AUX B-O -described VERB B-O -in ADP B-O -the DET B-O -/ITGB3-RTITGA2B PROPN B-AC -and CCONJ B-O -ITGB3 PROPN B-AC -genes NOUN B-O -. PUNCT B-O - -Another DET B-O -well ADV B-O -- PUNCT B-O -characterized VERB B-O -CTL PROPN B-AC -epitope NOUN B-O -, PUNCT B-O -from ADP B-O -Sendai PROPN B-LF -virus NOUN I-LF -nucleoprotein NOUN I-LF -( PUNCT B-O -SV PROPN B-AC -) PUNCT B-O -, PUNCT B-O -was AUX B-O -investigated VERB B-O -to PART B-O -provide VERB B-O -further ADJ B-O -evidence NOUN B-O -that SCONJ B-O --NPTAP PROPN B-AC -over NOUN B-O -- PUNCT B-O -expression NOUN B-O -can AUX B-O -augment VERB B-O -antiviral ADJ B-O -responses NOUN B-O -. PUNCT B-O - -Importantly ADV B-O -, PUNCT B-O -caspase-4 NOUN B-O -can AUX B-O -be AUX B-O -activated VERB B-O -by ADP B-O -increased VERB B-O -intracellular ADJ B-O -Ca2 NOUN B-O -+ NOUN B-O -level NOUN B-O -, PUNCT B-O -for ADP B-O -example NOUN B-O -, PUNCT B-O -ER PROPN B-AC -Ca2 NOUN B-O -+ NOUN B-O -release NOUN B-O -mediated VERB B-O -by ADP B-O -transmembrane NOUN B-LF -protein NOUN I-LF -173 NUM I-LF -( PUNCT B-O -TMEM173 PROPN B-AC -) PUNCT B-O -( PUNCT B-O -also ADV B-O -known VERB B-O -as ADP B-O -stimulator NOUN B-LF -of ADP I-LF -interferon NOUN I-LF -genes NOUN I-LF -( PUNCT B-O -STING PROPN B-AC -) PUNCT B-O -) PUNCT B-O -[ X B-O -56 X B-O -] PUNCT B-O -or CCONJ B-O -the DET B-O -SERCA PROPN B-AC -inhibitor NOUN B-O -thapsigargin NOUN B-O -[ X B-O -57 X B-O -] PUNCT B-O -. PUNCT B-O - -KO PROPN B-AC -, PUNCT B-O -knockout NOUN B-LF -; PUNCT B-O -mDia1 PROPN B-O -, PUNCT B-O -mammalian ADJ B-O -diaphanous ADJ B-O -homolog1 NOUN B-O -; PUNCT B-O -mDia3 PROPN B-O -, PUNCT B-O -mammalian ADJ B-O -diaphanous ADJ B-O -homolog3 NOUN B-O -; PUNCT B-O -WT PROPN B-AC -, PUNCT B-O -wild ADJ B-LF -- PUNCT I-LF -type NOUN I-LF -. PUNCT B-O - -Detection NOUN B-O -was AUX B-O -carried VERB B-O -out ADP B-O -in ADP B-O -multiple ADJ B-LF -reactions NOUN I-LF -monitoring NOUN I-LF -( PUNCT B-O -MRM PROPN B-AC -) PUNCT B-O -mode NOUN B-O -. PUNCT B-O - -A DET B-O -significant ADJ B-O -independent ADJ B-O -association NOUN B-O -was AUX B-O -found VERB B-O -between ADP B-O -serum ADJ B-O -CysC PROPN B-AC -and CCONJ B-O -GDM PROPN B-AC -in ADP B-O -the DET B-O -binary ADJ B-O -logistic ADJ B-O -regression NOUN B-O -analysis NOUN B-O -after SCONJ B-O -adjusted VERB B-O -for ADP B-O -age NOUN B-O -, PUNCT B-O -BMI PROPN B-AC -, PUNCT B-O -SP PROPN B-AC -, PUNCT B-O -DP PROPN B-AC -, PUNCT B-O -HbA1c PROPN B-AC -, PUNCT B-O -UA PROPN B-AC -, PUNCT B-O -TG PROPN B-AC -and CCONJ B-O -HOMA PROPN B-AC -ratio NOUN I-LF -( PUNCT B-O --IR[oddsOR PROPN B-AC -) PUNCT B-O -, PUNCT B-O -14.269 NUM B-O -; PUNCT B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval(CI NOUN I-LF -) PUNCT B-O -, PUNCT B-O -4.977–40.908 NUM B-O -, PUNCT B-O -P<0.001 NUM B-O -] PUNCT B-O -. PUNCT B-O - -Clinical ADJ B-O -investigators NOUN B-O -, PUNCT B-O -IRBs PROPN B-AC -, PUNCT B-O -data NOUN B-O -safety NOUN B-O -and CCONJ B-O -monitoring NOUN B-O -boards NOUN B-O -, PUNCT B-O -and CCONJ B-O -regulatory ADJ B-O -agencies NOUN B-O -( PUNCT B-O -e.g. X B-O -, PUNCT B-O -the DET B-O -European PROPN B-LF -Medicines PROPN I-LF -Agency PROPN I-LF -[ PUNCT B-O -EMA PROPN B-AC -] PUNCT B-O -and CCONJ B-O -the DET B-O -Food PROPN B-LF -and CCONJ I-LF -Drug PROPN I-LF -Administration PROPN I-LF -[ PUNCT B-O -FDA PROPN B-AC -] PUNCT B-O -) PUNCT B-O -are AUX B-O -all PRON B-O -charged VERB B-O -with ADP B-O -risk NOUN B-O -– PUNCT B-O -benefit NOUN B-O -assessment NOUN B-O -. PUNCT B-O - -RNA-seq PROPN B-AC -, PUNCT B-O -RNA NOUN B-LF -sequencing NOUN I-LF -. PUNCT B-O - -Parenteral ADJ B-O -nutrition NOUN B-O -can AUX B-O -be AUX B-O -provided VERB B-O -independently ADV B-O -( PUNCT B-O -total ADJ B-LF -parenteral ADJ I-LF -nutrition NOUN I-LF -, PUNCT B-O -TPN PROPN B-AC -) PUNCT B-O -, PUNCT B-O -or CCONJ B-O -be AUX B-O -combined VERB B-O -with ADP B-O -enteral ADJ B-O -nutrition NOUN B-O -. PUNCT B-O - -Studies NOUN B-O -in ADP B-O -Drosophila PROPN B-O -have AUX B-O -identified VERB B-O -conserved ADJ B-O -polarity NOUN B-O -factors NOUN B-O -that PRON B-O -define VERB B-O -the DET B-O -apical ADJ B-O -( PUNCT B-O -Crumbs PROPN B-O -, PUNCT B-O -Stardust PROPN B-O -, PUNCT B-O -Par-6 PROPN B-O -, PUNCT B-O -atypical ADJ B-LF -protein NOUN I-LF -kinase NOUN I-LF -C PROPN I-LF -[ X B-O -aPKC PROPN B-AC -] PUNCT B-O -) PUNCT B-O -, PUNCT B-O -junctional ADJ B-O -( PUNCT B-O -Bazooka PROPN B-LF -[ X B-O -Baz]/Par-3 PROPN B-AC -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -basolateral ADJ B-O -( PUNCT B-O -Scribbled VERB B-LF -[ X B-O -Scrib PROPN B-AC -] PUNCT B-O -, PUNCT B-O -Discs NOUN B-LF -large ADJ I-LF -[ X B-O -Dlg PROPN B-AC -] PUNCT B-O -, PUNCT B-O -Lethal ADJ B-O -[ X B-O -2 X B-O -] PUNCT B-O -giant ADJ B-O -larvae NOUN B-O -[ X B-O -Lgl PROPN B-AC -] PUNCT B-O -) PUNCT B-O -domains NOUN B-O -of ADP B-O -epithelial ADJ B-O -cells NOUN B-O -. PUNCT B-O - -The DET B-O -prevalence NOUN B-O -of ADP B-O -alcohol NOUN B-LF -use NOUN I-LF -disorder NOUN I-LF -( PUNCT B-O -AUD PROPN B-AC -) PUNCT B-O -was AUX B-O -14.2 NUM B-O -% PUNCT B-O -. PUNCT B-O - -In ADP B-O -addition NOUN B-O -, PUNCT B-O -wtBMMΦ PROPN B-AC -and CCONJ B-O -wtBMDCs PROPN B-AC -secrete VERB B-O -IFNα PROPN B-O -after ADP B-O -MNV-1 PROPN B-AC -- PUNCT B-O -infection NOUN B-O -, PUNCT B-O -as SCONJ B-O -determined VERB B-O -by ADP B-O -IFNα PROPN B-O -enzyme NOUN B-LF -- PUNCT I-LF -linked VERB I-LF -immunosorbent ADJ I-LF -assay NOUN I-LF -( PUNCT B-O -ELISA PROPN B-AC -) PUNCT B-O -( PUNCT B-O -data NOUN B-O -not PART B-O -shown VERB B-O -) PUNCT B-O -. PUNCT B-O - -Resource NOUN B-LF -utilization NOUN I-LF -groups NOUN I-LF -( PUNCT B-O -RUGs PROPN B-AC -) PUNCT B-O -were AUX B-O -introduced VERB B-O -as ADP B-O -the DET B-O -way NOUN B-O -per X B-O -diem X B-O -prospective ADJ B-O -payments NOUN B-O -are AUX B-O -set VERB B-O -for ADP B-O -Medicare PROPN B-O -- PUNCT B-O -reimbursed VERB B-O -SNF PROPN B-AC -care NOUN B-O -, PUNCT B-O -classifying VERB B-O -patients NOUN B-O -into ADP B-O -reimbursement NOUN B-O -categories NOUN B-O -based VERB B-O -on ADP B-O -rehabilitation NOUN B-O -service NOUN B-O -use NOUN B-O -: PUNCT B-O -ultra ADJ B-O -( PUNCT B-O -720 NUM B-O -+ NUM B-O -minutes NOUN B-O -/ SYM B-O -week NOUN B-O -) PUNCT B-O -, PUNCT B-O -very ADV B-O -high ADJ B-O -( PUNCT B-O -500–719 NUM B-O -) PUNCT B-O -, PUNCT B-O -high ADJ B-O -( PUNCT B-O -325–499 NUM B-O -) PUNCT B-O -, PUNCT B-O -medium ADJ B-O -( PUNCT B-O -150–324 NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -low ADJ B-O -( PUNCT B-O -45–149 NUM B-O -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -each DET B-O -country NOUN B-O -we PRON B-O -sought VERB B-O -published VERB B-O -and CCONJ B-O -unpublished ADJ B-O -documents NOUN B-O -( PUNCT B-O -situation NOUN B-O -reports NOUN B-O -, PUNCT B-O -official ADJ B-O -statistics NOUN B-O -, PUNCT B-O -evaluation NOUN B-O -reports NOUN B-O -, PUNCT B-O -technical ADJ B-O -documents NOUN B-O -, PUNCT B-O -guidelines NOUN B-O -for ADP B-O -victim NOUN B-O -identification NOUN B-O -, PUNCT B-O -and CCONJ B-O -public ADJ B-O -health NOUN B-O -reports NOUN B-O -) PUNCT B-O -from ADP B-O -national ADJ B-O -ministries NOUN B-O -of ADP B-O -health NOUN B-O -and CCONJ B-O -government NOUN B-O -offices NOUN B-O -, PUNCT B-O -the DET B-O -World PROPN B-LF -Health PROPN I-LF -Organization PROPN I-LF -( PUNCT B-O -WHO PROPN B-AC -) PUNCT B-O -, PUNCT B-O -non ADJ B-O -- ADJ B-O -governmental ADJ B-O -organisations NOUN B-O -, PUNCT B-O -and CCONJ B-O -voluntary ADJ B-O -groups NOUN B-O -. PUNCT B-O - -Immunofluorescence NOUN B-O -with ADP B-O -antibodies NOUN B-O -to ADP B-O -the DET B-O -myelin NOUN B-O -protein NOUN B-O -, PUNCT B-O -myelin NOUN B-LF -oligodendrocyte NOUN I-LF -glycoprotein NOUN I-LF -( PUNCT B-O -MOG PROPN B-AC -) PUNCT B-O -, PUNCT B-O -confirmed VERB B-O -the DET B-O -myelin NOUN B-O -integrity NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1A NUM B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -HLA PROPN B-O -- ADJ B-O -DR PROPN B-O -( PUNCT B-O -MHC PROPN B-O -class NOUN B-O -II NUM B-O -) PUNCT B-O -antibodies NOUN B-O -confirmed VERB B-O -the DET B-O -presence NOUN B-O -of ADP B-O -microglia NOUN B-O -with ADP B-O -an DET B-O -activated VERB B-O -morphology NOUN B-O -( PUNCT B-O -thicker ADJ B-O -and CCONJ B-O -shorter ADJ B-O -processes NOUN B-O -) PUNCT B-O -( PUNCT B-O -Fig PROPN B-O -1B NUM B-O -) PUNCT B-O -. PUNCT B-O - -Immunofluorescence NOUN B-O -for ADP B-O -Caspr1 PROPN B-O -localised VERB B-O -at ADP B-O -the DET B-O -paranodes NOUN B-O -demonstrated VERB B-O -that SCONJ B-O -Caspr1 PROPN B-O -- ADJ B-O -stained VERB B-O -paranodes NOUN B-O -( PUNCT B-O -2.8 NUM B-O -± SYM B-O -1.1 NUM B-O -μm NOUN B-O -) PUNCT B-O -were AUX B-O -significantly ADV B-O -21.7 NUM B-O -% NOUN B-O -longer ADJ B-O -on ADP B-O -average ADJ B-O -in ADP B-O -the DET B-O -MS PROPN B-AC -NAWM PROPN B-AC -tissue NOUN B-O -than ADP B-O -in ADP B-O -the DET B-O -non ADJ B-O -- ADJ B-O -neurological ADJ B-O -control NOUN B-O -tissue NOUN B-O -( PUNCT B-O -2.3 NUM B-O -± SYM B-O -0.8μm NUM B-O -, PUNCT B-O -Fig PROPN B-O -1C–1 NUM B-O -G PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Furthermore ADV B-O -, PUNCT B-O -43 NUM B-O -% NOUN B-O -of ADP B-O -the DET B-O -paranodes NOUN B-O -in ADP B-O -the DET B-O -MS PROPN B-AC -tissue NOUN B-O -were AUX B-O -longer ADJ B-O -than ADP B-O -the DET B-O -75 NUM B-O -% NOUN B-O -percentile NOUN B-O -of ADP B-O -the DET B-O -control NOUN B-O -group NOUN B-O -( PUNCT B-O -2.7 NUM B-O -μm NOUN B-O -) PUNCT B-O -, PUNCT B-O -and CCONJ B-O -11.14 NUM B-O -% NOUN B-O -were AUX B-O -longer ADJ B-O -than ADP B-O -4 NUM B-O -μm NOUN B-O -, PUNCT B-O -compared VERB B-O -to ADP B-O -the DET B-O -4.1 NUM B-O -% NOUN B-O -in ADP B-O -the DET B-O -non ADJ B-O -- ADJ B-O -neurological ADJ B-O -controls NOUN B-O -( PUNCT B-O -Fig PROPN B-O -1 NUM B-O -G PROPN B-O -) PUNCT B-O -. PUNCT B-O - -There PRON B-O -was VERB B-O -little ADJ B-O -difference NOUN B-O -between ADP B-O -the DET B-O -2 NUM B-O -brain NOUN B-O -areas NOUN B-O -examined VERB B-O -; PUNCT B-O -the DET B-O -paranodal ADJ B-O -lengths NOUN B-O -in ADP B-O -the DET B-O -cerebral ADJ B-O -peduncles NOUN B-O -of ADP B-O -the DET B-O -mesencephalon NOUN B-O -were AUX B-O -2.81 NUM B-O -± SYM B-O -0.019 NUM B-O -μm NOUN B-O -long ADJ B-O -, PUNCT B-O -and CCONJ B-O -12 NUM B-O -% NOUN B-O -of ADP B-O -them PRON B-O -were AUX B-O -> ADP B-O -4 NUM B-O -μm NOUN B-O -, PUNCT B-O -compared VERB B-O -to ADP B-O -those PRON B-O -in ADP B-O -the DET B-O -precentral ADJ B-O -gyrus NOUN B-O -, PUNCT B-O -which PRON B-O -were AUX B-O -2.79 NUM B-O -± SYM B-O -0.017 NUM B-O -μm NOUN B-O -long ADJ B-O -, PUNCT B-O -and CCONJ B-O -10 NUM B-O -% NOUN B-O -of ADP B-O -them PRON B-O -were AUX B-O -> ADP B-O -4 NUM B-O -μm NOUN B-O -( PUNCT B-O -S1 PROPN B-O -Fig PROPN B-O -) PUNCT B-O -. PUNCT B-O - -Class NOUN B-O -B NOUN B-O -enzymes NOUN B-O -are AUX B-O -zinc NOUN B-O -dependent ADJ B-O -metallo NOUN B-LF -- PUNCT I-LF -β PUNCT I-LF -- PUNCT I-LF -lactamases NOUN I-LF -( PUNCT B-O -MBLs PROPN B-AC -) PUNCT B-O -, PUNCT B-O -which PRON B-O -require VERB B-O -one NUM B-O -or CCONJ B-O -two NUM B-O -Zn2 NOUN B-O -+ NOUN B-O -in ADP B-O -their PRON B-O -active ADJ B-O -site NOUN B-O -for ADP B-O -catalysis NOUN B-O -[ PUNCT B-O -3 NUM B-O -, PUNCT B-O -4 NUM B-O -] PUNCT B-O -. PUNCT B-O - -In ADP B-O -the DET B-O -present ADJ B-O -study NOUN B-O -, PUNCT B-O -we PRON B-O -chose VERB B-O -to PART B-O -investigate VERB B-O -this PRON B-O -using VERB B-O -two NUM B-O -different ADJ B-O -kinds NOUN B-O -of ADP B-O -spatial ADJ B-O -memory NOUN B-O -tests NOUN B-O -: PUNCT B-O -the DET B-O -spontaneous ADJ B-LF -place NOUN I-LF -recognition NOUN I-LF -( PUNCT B-O -SPR PROPN B-AC -) PUNCT B-O -test NOUN B-O -and CCONJ B-O -the DET B-O -delay NOUN B-LF -- PUNCT I-LF -interposed VERB I-LF -radial ADJ I-LF -arm NOUN I-LF -maze NOUN I-LF -( PUNCT B-O -dRAM PROPN B-AC -) PUNCT B-O -task NOUN B-O -. PUNCT B-O - -For ADP B-O -EM PROPN B-AC -studies NOUN B-O -, PUNCT B-O -MRC5 PROPN B-O -cells NOUN B-O -were AUX B-O -infected VERB B-O -at ADP B-O -an DET B-O -m.o.i NOUN B-O -. PUNCT B-O - -of ADP B-O -5 NUM B-O -as SCONJ B-O -described VERB B-O -above ADV B-O -and CCONJ B-O -fixed VERB B-O -in ADP B-O -situ NOUN B-O -by ADP B-O -incubation NOUN B-O -for ADP B-O -48 NUM B-O -h NOUN B-O -in ADP B-O -4 NUM B-O -% NOUN B-O -PFA NOUN B-O -and CCONJ B-O -1 NUM B-O -% NOUN B-O -glutaraldehyde NOUN B-O -in ADP B-O -0.1 NUM B-O -M PROPN B-O -phosphate NOUN B-O -buffer NOUN B-O -( PUNCT B-O -pH NOUN B-O -7.2 NUM B-O -) PUNCT B-O -; PUNCT B-O -they PRON B-O -were AUX B-O -then ADV B-O -post VERB B-O -- VERB B-O -fixed VERB B-O -by ADP B-O -incubation NOUN B-O -for ADP B-O -1 NUM B-O -h NOUN B-O -with ADP B-O -2 NUM B-O -% NOUN B-O -osmium NOUN B-O -tetroxide NOUN B-O -( PUNCT B-O -Electron PROPN B-LF -Microscopy PROPN I-LF -Science PROPN B-O -, PUNCT B-O -http://www.emsdiasum.com X B-O -) PUNCT B-O -. PUNCT B-O - -Timely ADV B-O -and CCONJ B-O -an PRON B-O -accurate ADJ B-O -risk NOUN B-O -stratification NOUN B-O -of ADP B-O -patients NOUN B-O -in ADP B-O -the DET B-O -emergency NOUN B-LF -department NOUN I-LF -( PUNCT B-O -ED PROPN B-AC -) PUNCT B-O -supports VERB B-O -the DET B-O -clinician NOUN B-O -in ADP B-O -reducing VERB B-O -time NOUN B-O -to ADP B-O -effective ADJ B-O -treatment NOUN B-O -— PUNCT B-O -a DET B-O -key ADJ B-O -predictor NOUN B-O -for ADP B-O -patient NOUN B-O -outcome NOUN B-O -. PUNCT B-O - -HL PROPN B-AC -: PUNCT B-O -hyperlipidemia NOUN B-LF -Statistical ADJ B-O -analyses NOUN B-O -were AUX B-O -performed VERB B-O -using VERB B-O -logistic ADJ B-O -regression NOUN B-O -and CCONJ B-O -results NOUN B-O -were AUX B-O -reported VERB B-O -as ADP B-O -odds NOUN B-LF -ratio NOUN I-LF -( PUNCT B-O -OR PROPN B-AC -) PUNCT B-O -and CCONJ B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-O -interval NOUN B-O -( PUNCT B-O -95 NUM B-O -% NOUN B-O -CI NOUN B-O -) PUNCT B-O -. PUNCT B-O - -HBV PROPN B-AC -, PUNCT B-O -hepatitis NOUN B-LF -B PROPN I-LF -virus NOUN I-LF -; PUNCT B-O -HDV PROPN B-AC -, PUNCT B-O -hepatitis NOUN B-LF -D PROPN I-LF -virus NOUN I-LF -. PUNCT B-O - -Each DET B-O -green ADJ B-O -dot NOUN B-O -represents VERB B-O -a DET B-O -metabolic ADJ B-O -trait NOUN B-O -and CCONJ B-O -the DET B-O -positions NOUN B-O -of ADP B-O -the DET B-O -dots NOUN B-O -are AUX B-O -determined VERB B-O -by ADP B-O -difference NOUN B-O -in ADP B-O -mean ADJ B-O -offspring NOUN B-O -metabolite NOUN B-O -( PUNCT B-O -in ADP B-O -SD NOUN B-O -units NOUN B-O -) PUNCT B-O -for ADP B-O -each DET B-O -increase NOUN B-O -of ADP B-O -1 NUM B-O -- NOUN B-O -SD NOUN B-O -maternal ADJ B-O -body NOUN B-LF -mass NOUN I-LF -index NOUN I-LF -( PUNCT B-O -BMI PROPN B-AC -) PUNCT B-O -( PUNCT B-O -x NOUN B-O -- NOUN B-O -axis NOUN B-O -) PUNCT B-O -and CCONJ B-O -difference NOUN B-O -in ADP B-O -mean ADJ B-O -offspring NOUN B-O -metabolite NOUN B-O -( PUNCT B-O -in ADP B-O -SD NOUN B-O -units NOUN B-O -) PUNCT B-O -for ADP B-O -each DET B-O -increase NOUN B-O -in ADP B-O -1 NUM B-O -- NOUN B-O -SD NOUN B-O -paternal ADJ B-O -BMI PROPN B-AC -( PUNCT B-O -y NOUN B-O -- NOUN B-O -axis NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Acute ADJ B-LF -gastroenteritis NOUN I-LF -( PUNCT B-O -AGE PROPN B-AC -) PUNCT B-O -is AUX B-O -a DET B-O -common ADJ B-O -condition NOUN B-O -that PRON B-O -imposes VERB B-O -a DET B-O -significant ADJ B-O -burden NOUN B-O -on ADP B-O -communities NOUN B-O -and CCONJ B-O -healthcare NOUN B-O -systems NOUN B-O -worldwide ADV B-O -. PUNCT B-O - -We PRON B-O -developed VERB B-O -and CCONJ B-O -validated VERB B-O -a DET B-O -computational ADJ B-O -model NOUN B-O -of ADP B-O -signal NOUN B-LF -transducer NOUN I-LF -and CCONJ I-LF -activator NOUN I-LF -of ADP I-LF -transcription-3 NOUN I-LF -( PUNCT B-O -Stat3 PROPN B-AC -) PUNCT B-O -pathway NOUN B-O -kinetics NOUN B-O -, PUNCT B-O -a DET B-O -signaling NOUN B-O -network NOUN B-O -involved VERB B-O -in ADP B-O -embryonic ADJ B-O -stem NOUN B-O -cell NOUN B-O -( PUNCT B-O -ESC PROPN B-AC -) PUNCT B-O -self NOUN B-O -- PUNCT B-O -renewal NOUN B-O -. PUNCT B-O - -Electrophoretic ADJ B-LF -mobility NOUN I-LF -shift NOUN I-LF -assays NOUN I-LF -( PUNCT B-O -EMSAs PROPN B-AC -) PUNCT B-O -were AUX B-O -performed VERB B-O -using VERB B-O -the DET B-O -Lightshift PROPN B-O -chemi NOUN B-O -- PUNCT B-O -luminescence NOUN B-O -EMSA PROPN B-AC -kit NOUN B-O -( PUNCT B-O -Pierce PROPN B-O -) PUNCT B-O -according VERB B-O -to ADP B-O -the DET B-O -manufacturer NOUN B-O -’s PART B-O -instructions NOUN B-O -described VERB B-O -in ADP B-O -[ X B-O -65 NUM B-O -] PUNCT B-O -. PUNCT B-O - -The DET B-O -average NOUN B-O -of ADP B-O -3 NUM B-O -blood NOUN B-LF -pressures NOUN I-LF -( PUNCT B-O -BP PROPN B-AC -) PUNCT B-O -taken VERB B-O -5 NUM B-O -minutes NOUN B-O -apart ADV B-O -were AUX B-O -used VERB B-O -. PUNCT B-O - -Almost ADV B-O -all PRON B-O -women NOUN B-O -recruited VERB B-O -in ADP B-O -both DET B-O -study NOUN B-O -groups NOUN B-O -used VERB B-O -their PRON B-O -allocated VERB B-O -study NOUN B-O -treatment NOUN B-O -( PUNCT B-O -381 NUM B-O -[ X B-O -95.7 NUM B-O -% NOUN B-O -] PUNCT B-O -in ADP B-O -the DET B-O -progesterone NOUN B-O -group NOUN B-O -and CCONJ B-O -359 NUM B-O -[ X B-O -92.3 NUM B-O -% NOUN B-O -] PUNCT B-O -in ADP B-O -the DET B-O -placebo NOUN B-O -group NOUN B-O -) PUNCT B-O -, PUNCT B-O -with ADP B-O -similar ADJ B-O -median ADJ B-O -days NOUN B-O -of ADP B-O -use NOUN B-O -in ADP B-O -both DET B-O -study NOUN B-O -groups NOUN B-O -( PUNCT B-O -51.0 NUM B-O -days NOUN B-O -[ X B-O -interquartile ADJ B-LF -range NOUN I-LF -( PUNCT B-O -IQR PROPN B-AC -) PUNCT B-O -28.0–69.0 NUM B-O -] PUNCT B-O -in ADP B-O -the DET B-O -progesterone NOUN B-O -group NOUN B-O -versus ADP B-O -52.0 NUM B-O -days NOUN B-O -[ X B-O -IQR PROPN B-AC -27.0–76.0 NUM B-O -] PUNCT B-O -in ADP B-O -the DET B-O -placebo NOUN B-O -group NOUN B-O -) PUNCT B-O -( PUNCT B-O -Table PROPN B-O -1 NUM B-O -) PUNCT B-O -. PUNCT B-O - -As SCONJ B-O -shown VERB B-O -in ADP B-O -S5 NUM B-O -Fig PROPN B-O -, PUNCT B-O -and CCONJ B-O -consistent ADJ B-O -with ADP B-O -our PRON B-O -previous ADJ B-O -results NOUN B-O -, PUNCT B-O -ectopic ADJ B-O -induction NOUN B-O -of ADP B-O -all DET B-O -three NUM B-O -Su(H NOUN B-O -) PUNCT B-O -mutants NOUN B-O -in ADP B-O -the DET B-O -eye NOUN B-O -imaginal ADJ B-O -discs NOUN B-O -effects VERB B-O -eye NOUN B-O -morphology NOUN B-O -indistinguishable ADJ B-O -from ADP B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -Su(H NOUN B-O -) PUNCT B-O -, PUNCT B-O -but CCONJ B-O -the DET B-O -triple ADJ B-O -mutants NOUN B-O -Su(H)LLL PROPN B-AC -/ NOUN B-O -AAA NOUN B-O -and CCONJ B-O -Su(H)LLF PROPN B-AC -/ NOUN B-O -AAA NOUN B-O -retain VERB B-O -little ADJ B-O -to PART B-O -no PRON B-O -binding NOUN B-O -of ADP B-O -Hairless PROPN B-LF -in ADP B-O -vivo ADJ B-O -. PUNCT B-O - -This PRON B-O -is AUX B-O -fully ADV B-O -restored VERB B-O -in ADP B-O -Dble::R6/2 PROPN B-O -mice NOUN B-O -at ADP B-O -12 NUM B-O -wk NOUN B-O -of ADP B-O -age NOUN B-O -. PUNCT B-O - -( PUNCT B-O -K NOUN B-O -) PUNCT B-O -Representative ADJ B-O -traces NOUN B-O -of ADP B-O -miniature ADJ B-LF -EPSCs NOUN I-LF -EPSCs PROPN B-AC -( PUNCT B-O -mEPSCs PROPN B-AC -) PUNCT B-O -at ADP B-O -8 NUM B-O -wk NOUN B-O -. PUNCT B-O - -Status NOUN B-O -of ADP B-O -promoter NOUN B-O -region NOUN B-O -methylation NOUN B-O -of ADP B-O -O6 NOUN B-O -- PUNCT B-O -methylguanine NOUN B-O -DNA NOUN B-O -methyltransferase NOUN B-O -( PUNCT B-O -MGMT PROPN B-AC -) PUNCT B-O -and CCONJ B-O -Isocitrate NOUN B-LF -dehydrogenase NOUN I-LF -1 NUM B-O -and CCONJ B-O -2 NUM B-O -( PUNCT B-O -IDH PROPN B-AC -1/2 NUM B-O -) PUNCT B-O -mutations NOUN B-O -were AUX B-O -also ADV B-O -assessed VERB B-O -. PUNCT B-O - -The DET B-O -included VERB B-O -literature NOUN B-O -fulfilled VERB B-O -the DET B-O -following ADJ B-O -criteria NOUN B-O -: PUNCT B-O -( PUNCT B-O -1 X B-O -) PUNCT B-O -The DET B-O -case NOUN B-O -- PUNCT B-O -control NOUN B-O -studies NOUN B-O -or CCONJ B-O -cohort NOUN B-O -designs NOUN B-O -on ADP B-O -the DET B-O -correlation NOUN B-O -between ADP B-O -the DET B-O -polymorphism NOUN B-O -of ADP B-O -ADIPOQ NOUN B-O -gene NOUN B-O -rs2241766 NOUN B-O -or CCONJ B-O -rs1501299 NOUN B-O -and CCONJ B-O -T2DM PROPN B-AC -. PUNCT B-O - -( PUNCT B-O -2 X B-O -) PUNCT B-O -The DET B-O -genotype NOUN B-O -distribution NOUN B-O -conformed VERB B-O -to ADP B-O -the DET B-O -HWE PROPN B-AC -( PUNCT B-O -Hardy PROPN B-LF -- PUNCT I-LF -Weinberg PROPN I-LF -Equilibrium PROPN I-LF -) PUNCT B-O -balance NOUN B-O -in ADP B-O -the DET B-O -control NOUN B-O -population NOUN B-O -. PUNCT B-O - -( PUNCT B-O -3 X B-O -) PUNCT B-O -The DET B-O -genotype NOUN B-O -frequency NOUN B-O -, PUNCT B-O -the DET B-O -odds NOUN B-LF -ratio NOUN I-LF -( PUNCT B-O -OR PROPN B-AC -) PUNCT B-O -value NOUN B-O -, PUNCT B-O -or CCONJ B-O -95 NUM B-O -% NOUN B-O -confidence NOUN B-LF -interval NOUN I-LF -( PUNCT B-O -CI PROPN B-AC -) PUNCT B-O -were AUX B-O -directly ADV B-O -given VERB B-O -in ADP B-O -the DET B-O -literature NOUN B-O -. PUNCT B-O - -( PUNCT B-O -4 X B-O -) PUNCT B-O -The DET B-O -language NOUN B-O -of ADP B-O -the DET B-O -literature NOUN B-O -was AUX B-O -Chinese PROPN B-O -or CCONJ B-O -English PROPN B-O -. PUNCT B-O - -( PUNCT B-O -5 X B-O -) PUNCT B-O -For ADP B-O -multiple ADJ B-O -studies NOUN B-O -of ADP B-O -the DET B-O -same ADJ B-O -author NOUN B-O -, PUNCT B-O -the DET B-O -latest ADJ B-O -study NOUN B-O -or CCONJ B-O -that SCONJ B-O -with ADP B-O -sufficient ADJ B-O -data NOUN B-O -was AUX B-O -selected VERB B-O -. PUNCT B-O - -The DET B-O -median ADJ B-O -age NOUN B-O -was AUX B-O -45 NUM B-O -years NOUN B-O -( PUNCT B-O -interquartile ADJ B-LF -range NOUN I-LF -( PUNCT B-O -IQR PROPN B-AC -) PUNCT B-O -38–54 NUM B-O -) PUNCT B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -MACEs PROPN B-AC -: PUNCT B-O -major ADJ B-LF -adverse ADJ I-LF -cardiac ADJ I-LF -events NOUN I-LF -, PUNCT B-O -MI PROPN B-O -: PUNCT B-O -myocardial ADJ B-O -infarction NOUN B-O -, PUNCT B-O -TLR NOUN B-O -: PUNCT B-O -target NOUN B-O -lesion NOUN B-O -revascularization NOUN B-O -, PUNCT B-O -TVR NOUN B-O -: PUNCT B-O -target NOUN B-O -vessel NOUN B-O -revascularization NOUN B-O -, PUNCT B-O -ST NOUN B-O -: PUNCT B-O -stent NOUN B-O -thrombosis NOUN B-O -. PUNCT B-O - -Abbreviations NOUN B-O -: PUNCT B-O -ER PROPN B-AC -, PUNCT B-O -estrogen NOUN B-LF -receptor NOUN I-LF -; PUNCT B-O -PR PROPN B-AC -, PUNCT B-O -progesterone NOUN B-LF -receptor NOUN I-LF -; PUNCT B-O -HER2 PROPN B-O -, PUNCT B-O -Human PROPN B-O -epidermal ADJ B-O -growth NOUN B-O -factor NOUN B-O -receptor NOUN B-O -2 NUM B-O -; PUNCT B-O -FSH PROPN B-O -, PUNCT B-O -follicle NOUN B-O -stimulating VERB B-O -hormone NOUN B-O -; PUNCT B-O -AST PROPN B-AC -, PUNCT B-O -aspartate NOUN B-LF -aminotransferase NOUN I-LF -; PUNCT B-O -ALT PROPN B-AC -, PUNCT B-O -alanine NOUN B-LF -aminotransferase NOUN I-LF -; PUNCT B-O -HDL PROPN B-O -, PUNCT B-O -high ADJ B-O -- PUNCT B-O -density NOUN B-O -lipoprotein NOUN B-O -; PUNCT B-O -LDL NOUN B-O -, PUNCT B-O -low ADJ B-O -- PUNCT B-O -density NOUN B-O -lipoprotein NOUN B-O -; PUNCT B-O -NFS PROPN B-O -, PUNCT B-O -nonalcoholic ADJ B-O -fatty ADJ B-O -liver NOUN B-O -disease NOUN B-O -fibrosis NOUN B-O -score NOUN B-O -; PUNCT B-O -FIB-4 NOUN B-O -, PUNCT B-O -fibrosis-4 NOUN B-O -; PUNCT B-O -CT PROPN B-AC -, PUNCT B-O -computed VERB B-LF -tomography NOUN I-LF -. PUNCT B-O - -Worldwide ADV B-O -, PUNCT B-O -HPVs PROPN B-AC -are AUX B-O -known VERB B-O -to PART B-O -be AUX B-O -one NUM B-O -of ADP B-O -the DET B-O -most ADV B-O -common ADJ B-O -Sexually ADV B-LF -Transmitted VERB I-LF -Infections NOUN I-LF -( PUNCT B-O -STIs PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -Diet NOUN B-O -was AUX B-O -assessed VERB B-O -using VERB B-O -the DET B-O -FAST PROPN B-AC -( PUNCT B-O -Food PROPN B-LF -Assessment PROPN I-LF -in ADP I-LF -Schools PROPN I-LF -Tool PROPN I-LF -) PUNCT B-O -food NOUN B-O -diary NOUN B-O -method NOUN B-O -, PUNCT B-O -a DET B-O -method NOUN B-O -validated VERB B-O -for ADP B-O -use NOUN B-O -in ADP B-O -young ADJ B-O -children NOUN B-O -[ PUNCT B-O -14 NUM B-O -] PUNCT B-O -. PUNCT B-O - -BMI PROPN B-AC -was AUX B-O -also ADV B-O -determined VERB B-O -according VERB B-O -to PART B-O -the DET B-O -International PROPN B-O -Obesity PROPN B-O -Task PROPN B-O -Force PROPN B-O -( PUNCT B-O -IOTF PROPN B-AC -) PUNCT B-O -and CCONJ B-O -World PROPN B-LF -Health PROPN I-LF -Organization PROPN I-LF -( PUNCT B-O -WHO PROPN B-AC -) PUNCT B-O -criteria NOUN B-O -: PUNCT B-O -Thin ADJ B-O -< NUM B-O -5th ADJ B-O -centiles NOUN B-O -; PUNCT B-O -normal ADJ B-O -5th ADJ B-O -to PART B-O -< NUM B-O -85th ADJ B-O -centiles NOUN B-O -; PUNCT B-O -overweight ADJ B-O -85th ADJ B-O -to PART B-O -< NUM B-O -95th ADJ B-O -centiles NOUN B-O -; PUNCT B-O -obese ADJ B-O -95th ADJ B-O -to PART B-O -< NUM B-O -98th ADJ B-O -centiles NOUN B-O -; PUNCT B-O -and CCONJ B-O -extremely ADV B-O -- ADJ B-O -obese ADJ B-O -≥98th ADJ B-O -centiles NOUN B-O -[ PUNCT B-O -13 NUM B-O -] PUNCT B-O -. PUNCT B-O - -ECRL PROPN B-O -, PUNCT B-O -extensor NOUN B-O -carpi X B-O -radialis X B-O -longus X B-O -; PUNCT B-O -EEG PROPN B-AC -, PUNCT B-O -electroencephalography NOUN B-LF -; PUNCT B-O -EMG PROPN B-AC -, PUNCT B-O -electromyography NOUN B-LF -. PUNCT B-O - -Plasma NOUN B-O -interleukin-6 NOUN B-LF -( PUNCT B-O -IL-6 PROPN B-AC -) PUNCT B-O -levels NOUN B-O -were AUX B-O -quantitated VERB B-O -using VERB B-O -the DET B-O -MILLIPLEX PROPN B-O -® PROPN B-O -MAP PROPN B-O -Human PROPN B-O -High ADJ B-O -Sensitivity PROPN B-O -T PROPN B-O -Cell PROPN B-O -Magnetic PROPN B-O -Bead PROPN B-O -Panel PROPN B-O -immunoassay NOUN B-O -( PUNCT B-O -Merck PROPN B-O -KGaA PROPN B-O -, PUNCT B-O -Darmstadt PROPN B-O -, PUNCT B-O -Germany PROPN B-O -) PUNCT B-O -. PUNCT B-O - -After ADP B-O -staining VERB B-O -polytene NOUN B-O -chromosomes NOUN B-O -from ADP B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -larvae NOUN B-O -with ADP B-O -antibodies NOUN B-O -against ADP B-O -ISWI PROPN B-AC -and CCONJ B-O -the DET B-O -elongating VERB B-O -form NOUN B-O -of ADP B-O -Pol PROPN B-AC -( PUNCT B-O -Pol PROPN B-O -IIoser2 PROPN B-O -) PUNCT B-O -, PUNCT B-O -the DET B-O -positions NOUN B-O -of ADP B-O -potential ADJ B-O -target NOUN B-O -genes NOUN B-O -were AUX B-O -identified VERB B-O -by ADP B-O -fluorescent ADJ B-LF -in ADP I-LF -situ NOUN I-LF -hybridization NOUN I-LF -( PUNCT B-O -IIFISH PROPN B-AC -; PUNCT B-O -Figure PROPN B-O -3C NUM B-O -and CCONJ B-O -3D NOUN B-O -) PUNCT B-O -. PUNCT B-O - -For ADP B-O -these DET B-O -experiments NOUN B-O -, PUNCT B-O -we PRON B-O -selected VERB B-O -genes NOUN B-O -that PRON B-O -exhibited VERB B-O -at ADP B-O -least ADJ B-O -a DET B-O -2.5 ADJ B-O -- PUNCT B-O -fold ADJ B-O -change NOUN B-O -in ADP B-O -gene NOUN B-O -expression NOUN B-O -in ADP B-O -Iswi PROPN B-O -mutant ADJ B-O -versus ADP B-O -wild ADJ B-O -- PUNCT B-O -type NOUN B-O -male NOUN B-O -larvae NOUN B-O -. PUNCT B-O - -This PRON B-O -resulted VERB B-O -in ADP B-O -excluding VERB B-O -an DET B-O -average ADJ B-O -number NOUN B-O -of ADP B-O -voxels NOUN B-O -equal ADJ B-O -to ADP B-O -16.2 NUM B-O -% NOUN B-O -of ADP B-O -the DET B-O -region NOUN B-LF -EVC PROPN B-AC -of ADP I-LF -interest NOUN I-LF -( PUNCT B-O -ROI PROPN B-AC -; PUNCT B-O -range NOUN B-O -7.23%–31.55 NUM B-O -% NOUN B-O -across ADP B-O -participants NOUN B-O -) PUNCT B-O -. PUNCT B-O - -Tissue NOUN B-O -advanced ADJ B-LF -glycation NOUN I-LF -end NOUN I-LF -product NOUN I-LF -( PUNCT B-O -AGE PROPN B-AC -) PUNCT B-O -accumulation NOUN B-O -has AUX B-O -been AUX B-O -proposed VERB B-O -as ADP B-O -a DET B-O -marker NOUN B-O -of ADP B-O -cumulative ADJ B-O -metabolic ADJ B-O -stress NOUN B-O -that PRON B-O -can AUX B-O -be AUX B-O -assessed VERB B-O -noninvasively ADV B-O -by ADP B-O -measurement NOUN B-O -of ADP B-O -skin NOUN B-LF -autofluorescence NOUN I-LF -( PUNCT B-O -SAF PROPN B-AC -) PUNCT B-O -. PUNCT B-O - -In ADP B-O -persons NOUN B-O -on ADP B-O -haemodialysis NOUN B-O -, PUNCT B-O -SAF PROPN B-AC -is AUX B-O -an DET B-O -independent ADJ B-O -risk NOUN B-O -factor NOUN B-O -for ADP B-O -cardiovascular ADJ B-LF -events NOUN I-LF -( PUNCT B-O -CVEs PROPN B-AC -) PUNCT B-O -and CCONJ B-O -all DET B-LF -- PUNCT I-LF -cause NOUN I-LF -mortality NOUN I-LF -( PUNCT B-O -ACM PROPN B-AC -) PUNCT B-O -, PUNCT B-O -but CCONJ B-O -data NOUN B-O -at ADP B-O -earlier ADJ B-O -stages NOUN B-O -of ADP B-O -chronic ADJ B-LF -kidney NOUN I-LF -disease NOUN I-LF -( PUNCT B-O -CKD PROPN B-AC -) PUNCT B-O -are AUX B-O -inconclusive ADJ B-O -. PUNCT B-O - -If SCONJ B-O -the DET B-O -systolic ADJ B-LF -blood NOUN I-LF -pressure NOUN I-LF -( PUNCT B-O -SBP PROPN B-AC -) PUNCT B-O -or CCONJ B-O -diastolic ADJ B-LF -blood NOUN I-LF -pressure NOUN I-LF -( PUNCT B-O -DBP PROPN B-AC -) PUNCT B-O -exceeded VERB B-O -140 NUM B-O -mmHg NOUN B-O -or CCONJ B-O -90 NUM B-O -mmHg NOUN B-O -, PUNCT B-O -respectively ADV B-O -, PUNCT B-O -the DET B-O -measurement NOUN B-O -was AUX B-O -repeated VERB B-O -after ADP B-O -5 NUM B-O -min NOUN B-O -, PUNCT B-O -and CCONJ B-O -the DET B-O -results NOUN B-O -were AUX B-O -averaged VERB B-O -. PUNCT B-O - -The DET B-O -largest ADJ B-O -cluster NOUN B-O -( PUNCT B-O -# PUNCT B-O -0 NUM B-O -) PUNCT B-O -has VERB B-O -16 NUM B-O -members NOUN B-O -, PUNCT B-O -a DET B-O -silhouette NOUN B-O -value NOUN B-O -of ADP B-O -0.789 NUM B-O -and CCONJ B-O -is AUX B-O -labeled VERB B-O -as ADP B-O -carcinogenic ADJ B-O -aristolochic ADJ B-O -acid NOUN B-O -by ADP B-O -LLR PROPN B-AC -( PUNCT B-O -log ADJ B-LF -- PUNCT I-LF -likelihood NOUN I-LF -ratio NOUN I-LF -) PUNCT B-O -. PUNCT B-O - -As SCONJ B-O -shown VERB B-O -in ADP B-O -Figure NOUN B-O -1B NUM B-O -, PUNCT B-O -quantitative ADJ B-O -PCR NOUN B-O -experiments NOUN B-O -demonstrated VERB B-O -that SCONJ B-O -β PUNCT B-O