For ADP B-O
this DET B-O
purpose NOUN B-O
the DET B-O
Gothenburg PROPN B-LF
Young PROPN I-LF
Persons PROPN I-LF
Empowerment PROPN I-LF
Scale PROPN I-LF
( PUNCT B-O
GYPES PROPN B-AC
) PUNCT B-O
was AUX B-O
developed VERB B-O
. PUNCT B-O

The DET B-O
following ADJ B-O
physiological ADJ B-O
traits NOUN B-O
were AUX B-O
measured VERB B-O
: PUNCT B-O
stomatal ADJ B-LF
conductance NOUN I-LF
( PUNCT B-O
gs PROPN B-AC
, PUNCT B-O
mol NOUN B-O
H2O NOUN B-O
m-2 NOUN B-O
s-1 NOUN B-O
) PUNCT B-O
, PUNCT B-O
transpiration NOUN B-LF
rate NOUN I-LF
( PUNCT B-O
E PROPN B-AC
, PUNCT B-O
mmol NOUN B-O
H2O NOUN B-O
m-2 NOUN B-O
s-1 NOUN B-O
) PUNCT B-O
, PUNCT B-O
net ADJ B-LF
photosynthetic ADJ I-LF
rate NOUN I-LF
( PUNCT B-O
PN PROPN B-AC
, PUNCT B-O
μmol NOUN B-O
m-2 NOUN B-O
s-1 NOUN B-O
) PUNCT B-O
and CCONJ B-O
intercellular ADJ B-LF
CO2 NOUN I-LF
concentration NOUN I-LF
CO2 PROPN B-AC
( PUNCT B-O
Ci PROPN B-AC
, PUNCT B-O
μmol NOUN B-O
m-2 NOUN B-O
s-1 NOUN B-O
) PUNCT B-O
. PUNCT B-O

Minor ADJ B-O
H PROPN B-AC
antigen NOUN B-O
alloimmune ADJ B-O
responses NOUN B-O
readily ADV B-O
occur VERB B-O
in ADP B-O
the DET B-O
setting NOUN B-O
of ADP B-O
human ADJ B-LF
leukocyte NOUN I-LF
antigen NOUN I-LF
( PUNCT B-O
HLA)–matched PROPN B-AC
allogeneic ADJ B-O
solid ADJ B-O
organ NOUN B-O
and CCONJ B-O
stem NOUN B-LF
cell NOUN I-LF
transplantation NOUN I-LF
( PUNCT B-O
SCT PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
3,4 NUM B-O
] PUNCT B-O
. PUNCT B-O

EPI PROPN B-AC
= PUNCT B-O
Echo NOUN B-LF
planar NOUN I-LF
imaging NOUN I-LF
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
eNOS PROPN B-AC
- PUNCT B-O
derived VERB B-O
NO PROPN B-AC
S NOUN B-O
- PUNCT B-O
nitrosylated VERB B-O
β PUNCT B-O
- PUNCT B-O
actin NOUN B-O
on ADP B-O
Cys374 PROPN B-O
and CCONJ B-O
impaired VERB B-O
actin NOUN B-O
binding VERB B-O
to ADP B-O
profilin-1 NOUN B-LF
( PUNCT B-O
PFN1 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
as SCONJ B-O
confirmed VERB B-O
with ADP B-O
the DET B-O
transnitrosylating NOUN B-O
agent NOUN B-O
S NOUN B-LF
- PUNCT I-LF
nitroso NOUN I-LF
- PUNCT I-LF
L NOUN I-LF
- PUNCT I-LF
cysteine NOUN I-LF
( PUNCT B-O
Cys-NO PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The PROPN B-AC
importance NOUN B-O
of ADP B-O
NO PROPN B-AC
and CCONJ B-O
the DET B-O
formation NOUN B-O
of ADP B-O
PFN1 PROPN B-AC
- PUNCT B-O
actin NOUN B-O
complexes NOUN B-O
on ADP B-O
the DET B-O
regulation NOUN B-O
of ADP B-O
PKC PROPN B-AC
was AUX B-O
corroborated VERB B-O
by ADP B-O
overexpression NOUN B-O
of ADP B-O
-θPFN1- PROPN B-AC
and CCONJ B-O
actin NOUN B-O
- PUNCT B-O
binding VERB B-O
defective ADJ B-O
mutants NOUN B-O
of ADP B-O
β PUNCT B-O
- PUNCT B-O
actin NOUN B-O
( PUNCT B-O
C374S PROPN B-O
) PUNCT B-O
and CCONJ B-O
PFN1 PROPN B-AC
( PUNCT B-O
H119E PROPN B-O
) PUNCT B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
which PRON B-O
reduced VERB B-O
the DET B-O
coalescence NOUN B-O
of ADP B-O
PKC PROPN B-AC
at ADP B-O
the DET B-O
-θc-SMAC PROPN B-AC
. PUNCT B-O

These DET B-O
findings NOUN B-O
unveil VERB B-O
a DET B-O
novel ADJ B-O
NO PROPN B-AC
- PUNCT B-O
dependent ADJ B-O
mechanism NOUN B-O
by ADP B-O
which PRON B-O
the DET B-O
actin NOUN B-O
cytoskeleton NOUN B-O
controls VERB B-O
the DET B-O
organization NOUN B-O
and CCONJ B-O
activation NOUN B-O
of ADP B-O
signaling NOUN B-O
microclusters NOUN B-O
at ADP B-O
the DET B-O
IS PROPN B-AC
. PUNCT B-O

Both DET B-O
Mekk3 PROPN B-O
cKO PROPN B-AC
and CCONJ B-O
their PRON B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
( PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
littermates NOUN B-O
were AUX B-O
labeled VERB B-O
at ADP B-O
E16.5 NUM B-O
with ADP B-O
5 NUM B-LF
- PUNCT I-LF
bromo-2’-deoxyuridine NOUN I-LF
( PUNCT B-O
BrdU PROPN B-AC
) PUNCT B-O
to PART B-O
track VERB B-O
cells NOUN B-O
undergoing VERB B-O
DNA NOUN B-O
synthesis NOUN B-O
. PUNCT B-O

Recent ADJ B-O
work NOUN B-O
by ADP B-O
us PRON B-O
and CCONJ B-O
others NOUN B-O
suggests VERB B-O
that SCONJ B-O
the DET B-O
host NOUN B-O
’s PART B-O
heat NOUN B-LF
shock NOUN I-LF
protein NOUN I-LF
90 NUM I-LF
( PUNCT B-O
Hsp90 PROPN B-AC
) PUNCT B-O
chaperone NOUN B-O
can AUX B-O
modulate VERB B-O
the DET B-O
evolutionary ADJ B-O
paths NOUN B-O
traversed VERB B-O
by ADP B-O
viruses NOUN B-O
[ PUNCT B-O
18 NUM B-O
, PUNCT B-O
19 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
performed VERB B-O
a DET B-O
linear ADJ B-O
regression NOUN B-O
model NOUN B-O
of ADP B-O
the DET B-O
effect NOUN B-O
of ADP B-O
PCL PROPN B-AC
on ADP B-O
Dizziness PROPN B-LF
Handicap PROPN I-LF
Inventory PROPN I-LF
( PUNCT B-O
DHI PROPN B-AC
) PUNCT B-O
. PUNCT B-O

DHI PROPN B-AC
was AUX B-O
significantly ADV B-O
correlated VERB B-O
to ADP B-O
PCL PROPN B-AC
scores NOUN B-O
, PUNCT B-O
suggesting VERB B-O
that SCONJ B-O
Veterans NOUN B-O
with ADP B-O
more ADJ B-O
severe ADJ B-O
PTSD PROPN B-AC
symptoms NOUN B-O
also ADV B-O
had VERB B-O
more ADJ B-O
dizziness NOUN B-O
handicap NOUN B-O
as SCONJ B-O
illustrated VERB B-O
in ADP B-O
Fig NUM B-O
2 NUM B-O
( PUNCT B-O
r2 NOUN B-O
= SYM B-O
0.28 NUM B-O
, PUNCT B-O
p NOUN B-O
< SYM B-O
0.0001 NUM B-O
) PUNCT B-O
. PUNCT B-O

Correlation NOUN B-O
of ADP B-O
( PUNCT B-O
a X B-O
) PUNCT B-O
rate NOUN B-O
of ADP B-O
seed NOUN B-O
mass NOUN B-O
evolution NOUN B-O
and CCONJ B-O
( PUNCT B-O
b X B-O
) PUNCT B-O
seed NOUN B-O
mass NOUN B-O
with ADP B-O
speciation NOUN B-O
rate NOUN B-O
( PUNCT B-O
λ PUNCT B-O
) PUNCT B-O
estimated VERB B-O
by ADP B-O
using VERB B-O
R PROPN B-LF
: PUNCT I-LF
Phylogenetic PROPN I-LF
ANalyses PROPN I-LF
of ADP I-LF
DiversificAtion PROPN I-LF
( PUNCT B-O
RPANDA PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
clade NOUN B-O
- PUNCT B-O
based VERB B-O
analysis NOUN B-O
. PUNCT B-O

Typically ADV B-O
, PUNCT B-O
at ADP B-O
low ADJ B-O
inspiratory ADJ B-LF
positive ADJ I-LF
airway NOUN I-LF
pressure NOUN I-LF
( PUNCT B-O
IPAP PROPN B-AC
) PUNCT B-O
values NOUN B-O
, PUNCT B-O
short ADJ B-O
PLBD PROPN B-AC
and CCONJ B-O
low ADJ B-O
PLBP PROPN B-AC
are AUX B-O
set VERB B-O
, PUNCT B-O
at ADP B-O
higher ADJ B-O
IPAP PROPN B-AC
values NOUN B-O
, PUNCT B-O
longer ADJ B-O
PLBD PROPN B-AC
and CCONJ B-O
higher ADJ B-O
PLBP PROPN B-AC
are AUX B-O
set VERB B-O
. PUNCT B-O

When SCONJ B-O
considering VERB B-O
the DET B-O
appropriateness NOUN B-O
of ADP B-O
introducing VERB B-O
an DET B-O
ACP PROPN B-AC
protocol NOUN B-O
at ADP B-O
KCMC PROPN B-AC
, PUNCT B-O
it PRON B-O
was AUX B-O
evident ADJ B-O
that SCONJ B-O
there PRON B-O
was AUX B-O
a DET B-O
literature NOUN B-O
deficit NOUN B-O
on ADP B-O
the DET B-O
cultural ADJ B-O
views NOUN B-O
of ADP B-O
quality NOUN B-LF
of ADP I-LF
death NOUN I-LF
( PUNCT B-O
QoD PROPN B-AC
) PUNCT B-O
in ADP B-O
Tanzania PROPN B-O
but CCONJ B-O
two NUM B-O
previous ADJ B-O
studies NOUN B-O
from ADP B-O
northern ADJ B-O
Tanzania PROPN B-O
had AUX B-O
indicated VERB B-O
that SCONJ B-O
QoD PROPN B-AC
was AUX B-O
an DET B-O
existing VERB B-O
concept NOUN B-O
in ADP B-O
northern ADJ B-O
Tanzania PROPN B-O
. PUNCT B-O

Positive ADJ B-O
cells NOUN B-O
from ADP B-O
each DET B-O
specimen NOUN B-O
were AUX B-O
counted VERB B-O
from ADP B-O
a DET B-O
minimum NOUN B-O
of ADP B-O
four NUM B-O
randomly ADV B-O
selected VERB B-O
fields NOUN B-O
per ADP B-O
high ADJ B-LF
power NOUN I-LF
field NOUN I-LF
( PUNCT B-O
HPF PROPN B-AC
) PUNCT B-O
and CCONJ B-O
compared VERB B-O
with ADP B-O
the DET B-O
control NOUN B-O
by ADP B-O
calculating VERB B-O
the DET B-O
average ADJ B-O
number NOUN B-O
of ADP B-O
cells NOUN B-O
. PUNCT B-O

FSC PROPN B-O
, PUNCT B-O
Fourier PROPN B-O
Shell PROPN B-O
Correlation PROPN B-O
; PUNCT B-O
MrNV PROPN B-AC
, PUNCT B-O
M. PROPN B-O
rosenbergii PROPN B-O
nodavirus NOUN B-O
; PUNCT B-O
3D PROPN B-AC
, PUNCT B-O
three NUM B-LF
- PUNCT I-LF
dimensional ADJ I-LF
. PUNCT B-O

In ADP B-O
rodent ADJ B-O
taste NOUN B-O
cells NOUN B-O
, PUNCT B-O
expression NOUN B-O
of ADP B-O
insulin NOUN B-O
and CCONJ B-O
the DET B-O
insulin NOUN B-LF
receptor NOUN I-LF
subunit NOUN I-LF
α PUNCT I-LF
( PUNCT B-O
IRα PROPN B-AC
) PUNCT B-O
has AUX B-O
been AUX B-O
proposed VERB B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
, PUNCT B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

To PART B-O
test VERB B-O
this PRON B-O
, PUNCT B-O
we PRON B-O
exposed VERB B-O
the DET B-O
mouse NOUN B-O
intestine NOUN B-O
to ADP B-O
two NUM B-O
conditions NOUN B-O
: PUNCT B-O
1 X B-O
) PUNCT B-O
30 NUM B-O
min NOUN B-O
of ADP B-O
ischemia NOUN B-O
followed VERB B-O
by ADP B-O
30 NUM B-O
min NOUN B-O
of ADP B-O
reperfusion NOUN B-O
stress NOUN B-O
, PUNCT B-O
and CCONJ B-O
2 X B-O
) PUNCT B-O
ischemia NOUN B-LF
/ SYM I-LF
reperfusion NOUN I-LF
( PUNCT B-O
I/R PROPN B-AC
) PUNCT B-O
stress NOUN B-O
coupled VERB B-O
with ADP B-O
luminal ADJ B-O
inoculation NOUN B-O
with ADP B-O
P. NOUN B-O
aeruginosa NOUN B-O
( PUNCT B-O
I PROPN B-AC
+ CCONJ B-O
Pa PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
localization NOUN B-O
of ADP B-O
motility NOUN B-O
complexes NOUN B-O
, PUNCT B-O
and CCONJ B-O
thereby ADV B-O
the DET B-O
direction NOUN B-O
of ADP B-O
movement NOUN B-O
, PUNCT B-O
is AUX B-O
determined VERB B-O
by ADP B-O
an DET B-O
oscillatory ADJ B-O
system NOUN B-O
, PUNCT B-O
which PRON B-O
includes VERB B-O
Mutual PROPN B-LF
gliding NOUN I-LF
motility NOUN I-LF
A NOUN I-LF
( PUNCT B-O
MglA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
small ADJ B-O
Ras PROPN B-O
- PUNCT B-O
like ADJ B-O
GTPase NOUN B-O
, PUNCT B-O
and CCONJ B-O
Mutual PROPN B-LF
gliding NOUN I-LF
motility NOUN I-LF
B NOUN I-LF
( PUNCT B-O
MglB PROPN B-AC
) PUNCT B-O
, PUNCT B-O
its PRON B-O
GTPase NOUN B-LF
activating VERB I-LF
protein NOUN I-LF
( PUNCT B-O
GAP PROPN B-AC
) PUNCT B-O
as ADP B-O
major ADJ B-O
components NOUN B-O
[ X B-O
1,4,5 NUM B-O
] PUNCT B-O
. PUNCT B-O

Using VERB B-O
chemical NOUN B-O
cross NOUN B-O
- PUNCT B-O
linking NOUN B-O
/ SYM B-O
MS PROPN B-AC
, PUNCT B-O
we PRON B-O
had AUX B-O
been AUX B-O
able ADJ B-O
to PART B-O
monitor VERB B-O
conformational ADJ B-O
changes NOUN B-O
in ADP B-O
the DET B-O
ligand NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
domain NOUN I-LF
( PUNCT B-O
LBD PROPN B-AC
) PUNCT B-O
of ADP B-O
PPAR PROPN B-AC
- PUNCT B-O
α PUNCT B-O
upon SCONJ B-O
ligand NOUN B-O
binding.[8 NOUN B-O
] PUNCT B-O
Inbred ADJ B-O
line NOUN B-O
L8 PROPN B-O
was AUX B-O
about ADV B-O
the DET B-O
most ADV B-O
distant ADJ B-O
line NOUN B-O
to ADP B-O
the DET B-O
three NUM B-O
testers NOUN B-O
based VERB B-O
on ADP B-O
both DET B-O
GDs PROPN B-AC
. PUNCT B-O

As SCONJ B-O
shown VERB B-O
in ADP B-O
Fig NOUN B-O
1 NUM B-O
, PUNCT B-O
the DET B-O
genetic ADJ B-LF
distance NOUN I-LF
estimates NOUN B-O
between ADP B-O
the DET B-O
Striga PROPN B-O
resistant ADJ B-O
lines NOUN B-O
and CCONJ B-O
the DET B-O
resistant ADJ B-O
tester NOUN B-O
were AUX B-O
broader ADJ B-O
in ADP B-O
the DET B-O
range NOUN B-O
of ADP B-O
GD PROPN B-AC
values NOUN B-O
than ADP B-O
those PRON B-O
between ADP B-O
the DET B-O
Striga PROPN B-O
- PUNCT B-O
resistant ADJ B-O
and CCONJ B-O
susceptible ADJ B-O
tester NOUN B-O
, PUNCT B-O
indicating VERB B-O
the DET B-O
resistant ADJ B-O
tester NOUN B-O
was AUX B-O
considered VERB B-O
as ADP B-O
a DET B-O
suitable ADJ B-O
tester NOUN B-O
. PUNCT B-O

Cardiac ADJ B-O
inflammation NOUN B-O
induced VERB B-O
by ADP B-O
B. PROPN B-O
burgdorferi PROPN B-O
is AUX B-O
dependent ADJ B-O
on ADP B-O
the DET B-O
interaction NOUN B-O
of ADP B-O
the DET B-O
spirochete NOUN B-O
with ADP B-O
macrophages NOUN B-O
and CCONJ B-O
other ADJ B-O
cell NOUN B-O
types NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
invariant ADJ B-LF
NKT NOUN I-LF
( PUNCT B-O
iNKT PROPN B-AC
) PUNCT B-O
or CCONJ B-O
T NOUN B-O
cells NOUN B-O
[ PUNCT B-O
35 NUM B-O
] PUNCT B-O
. PUNCT B-O

Data NOUN B-O
are AUX B-O
expressed VERB B-O
as ADP B-O
mean NOUN B-O
± ADP B-O
SEM PROPN B-AC
, PUNCT B-O
n NOUN B-O
= SYM B-O
3 NUM B-O
from ADP B-O
at ADV B-O
least ADV B-O
three NUM B-O
independent ADJ B-O
experiments NOUN B-O
; PUNCT B-O
nd PROPN B-AC
: PUNCT B-O
not PART B-LF
detected VERB I-LF
or CCONJ B-O
below ADP B-O
the DET B-O
limit NOUN B-O
of ADP B-O
quantitation NOUN B-O
. PUNCT B-O

BMI NOUN B-O
: PUNCT B-O
body NOUN B-O
mass NOUN B-O
index NOUN B-O
; PUNCT B-O
CE PROPN B-AC
: PUNCT B-O
cholesteryl ADJ B-O
ester NOUN B-O
; PUNCT B-O
ELF PROPN B-AC
: PUNCT B-O
epithelial ADJ B-LF
lining NOUN I-LF
fluid NOUN I-LF
; PUNCT B-O
FEV1 PROPN B-AC
: PUNCT B-O
forced VERB B-LF
expiratory ADJ I-LF
volume NOUN I-LF
in ADP I-LF
1 NUM I-LF
second NOUN I-LF
; PUNCT B-O
FVC PROPN B-AC
: PUNCT B-O
forced VERB B-LF
vital ADJ I-LF
capacity NOUN I-LF
; PUNCT B-O
IL PROPN B-O
: PUNCT B-O
Interleukin NOUN B-O
; PUNCT B-O
LABA PROPN B-O
: PUNCT B-O
long VERB B-O
acting VERB B-O
beta NOUN B-O
agonists NOUN B-O
; PUNCT B-O
LAMA PROPN B-O
: PUNCT B-O
long VERB B-O
acting VERB B-O
muscarinic ADJ B-O
antagonists NOUN B-O
; PUNCT B-O
MCP-1 NOUN B-O
: PUNCT B-O
macrophage NOUN B-O
chemotactic ADJ B-O
protein-1 NOUN B-O
; PUNCT B-O
TG PROPN B-AC
: PUNCT B-O
triglyceride NOUN B-O
. PUNCT B-O

DEFF PROPN B-AC
: PUNCT B-O
Design NOUN B-LF
effect NOUN I-LF
; PUNCT B-O
ICC PROPN B-AC
: PUNCT B-O
Intracluster ADJ B-LF
correlation NOUN I-LF
coefficient NOUN I-LF
; PUNCT B-O
SD PROPN B-AC
: PUNCT B-O
Standard ADJ B-LF
deviation NOUN I-LF
; PUNCT B-O
IQR PROPN B-AC
: PUNCT B-O
Interquartile ADJ B-LF
range NOUN I-LF
. PUNCT B-O

The DET B-O
leading VERB B-O
causes NOUN B-O
of ADP B-O
death NOUN B-O
and CCONJ B-O
morbidity NOUN B-O
worldwide ADV B-O
are AUX B-O
noncommunicable ADJ B-LF
diseases NOUN I-LF
( PUNCT B-O
NCDs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
chronic ADJ B-O
respiratory ADJ B-O
disease NOUN B-O
, PUNCT B-O
cancer NOUN B-O
, PUNCT B-O
diabetes NOUN B-O
, PUNCT B-O
and CCONJ B-O
, PUNCT B-O
in ADP B-O
particular ADJ B-O
, PUNCT B-O
ischemic ADJ B-O
heart NOUN B-O
disease NOUN B-O
and CCONJ B-O
stroke NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
slope NOUN B-O
of ADP B-O
field NOUN B-LF
excitatory ADJ I-LF
postsynaptic ADJ I-LF
potentials NOUN I-LF
( PUNCT B-O
fEPSPs PROPN B-AC
) PUNCT B-O
( PUNCT B-O
Fig NOUN B-O
6B NUM B-O
) PUNCT B-O
was AUX B-O
measured VERB B-O
to PART B-O
monitor VERB B-O
synaptic ADJ B-O
activation NOUN B-O
of ADP B-O
the DET B-O
CA1 NOUN B-O
pyramidal ADJ B-O
neurons NOUN B-O
. PUNCT B-O

BAZ PROPN B-AC
, PUNCT B-O
BMI NOUN B-LF
- PUNCT I-LF
BMI PROPN B-AC
for ADP I-LF
- PUNCT I-LF
age NOUN I-LF
z- NOUN B-O
score NOUN B-O
; PUNCT B-O
T PROPN B-AC
, PUNCT B-O
triene NOUN B-O
- PUNCT B-O
to ADP B-O
- PUNCT B-O
tetraene NOUN B-O
These DET B-O
supercomplexes NOUN B-O
are AUX B-O
associations NOUN B-O
of ADP B-O
oxidase NOUN B-O
with ADP B-O
either CCONJ B-O
respiratory ADJ B-O
complexIII PROPN B-AC
and CCONJ B-O
cytochrome NOUN B-LF
c552 NOUN I-LF
( PUNCT B-O
Sc NOUN B-O
: PUNCT B-O
III4IV2 NUM B-O
, PUNCT B-O
Sb NOUN B-O
: PUNCT B-O
III4IV4 NUM B-O
) PUNCT B-O
or CCONJ B-O
of ADP B-O
complex PROPN B-AC
, PUNCT B-O
IIIcomplexI PROPN B-AC
and CCONJ B-O
cyt PROPN B-AC
( PUNCT B-O
Sa NOUN B-O
: PUNCT B-O
I1III4IV4 NOUN B-O
; PUNCT B-O
S1 NOUN B-O
, PUNCT B-O
S3 PROPN B-O
and CCONJ B-O
S4 PROPN B-O
Figs NOUN B-O
) PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
Ct PROPN B-AC
, PUNCT B-O
cycle NOUN B-LF
threshold NOUN I-LF
; PUNCT B-O
n NOUN B-O
/ SYM B-O
a NOUN B-O
, PUNCT B-O
not PART B-O
applicable ADJ B-O
; PUNCT B-O
N1 PROPN B-AC
, PUNCT B-O
SARS PROPN B-LF
- PUNCT I-LF
SARS PROPN B-AC
CoV-2 NOUN I-LF
nucleocapsid NOUN I-LF
gene NOUN I-LF
region NOUN I-LF
1 NUM I-LF
; PUNCT B-O
-CoV-2SARS PROPN B-AC
, PUNCT B-O
severe ADJ B-LF
acute ADJ I-LF
respiratory ADJ I-LF
syndrome NOUN I-LF
coronavirus NOUN I-LF
2 NUM I-LF
; PUNCT B-O
Unk PROPN B-O
, PUNCT B-O
Unknown ADJ B-O
To PART B-O
further ADV B-O
identify VERB B-O
significant ADJ B-O
correlations NOUN B-O
between ADP B-O
phenotypes NOUN B-O
and CCONJ B-O
GO PROPN B-AC
concepts NOUN B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
a DET B-O
GO PROPN B-AC
term NOUN B-O
finder NOUN B-O
software NOUN B-O
[ X B-O
49 X B-O
] X B-O
to ADP B-O
correlate VERB B-O
phenotypes NOUN B-O
with ADP B-O
GO PROPN B-AC
using VERB B-O
the DET B-O
Pfam PROPN B-AC
to ADP B-O
GO PROPN B-AC
mapping NOUN B-O
data NOUN B-O
from ADP B-O
the DET B-O
Gene PROPN B-LF
Ontology PROPN I-LF
Consortium PROPN B-O
. PUNCT B-O

Crude ADJ B-LF
lipid NOUN I-LF
extract NOUN I-LF
( PUNCT B-O
CLE PROPN B-AC
in ADP B-O
mg NOUN B-O
) PUNCT B-O
was AUX B-O
estimated VERB B-O
following VERB B-O
Cointet PROPN B-O
et PROPN B-O
al PROPN B-O
. PUNCT B-O

( PUNCT B-O
2019 NUM B-O
) PUNCT B-O
and CCONJ B-O
lipid NOUN B-O
content NOUN B-O
( PUNCT B-O
LC NOUN B-O
) PUNCT B-O
was AUX B-O
estimated VERB B-O
in ADP B-O
mg NOUN B-O
. PUNCT B-O

L-1 NOUN B-O
. PUNCT B-O

One NUM B-O
day NOUN B-O
after ADP B-O
the DET B-O
preparation NOUN B-O
, PUNCT B-O
slice NOUN B-O
cultures NOUN B-O
were AUX B-O
transduced VERB B-O
with ADP B-O
adeno NOUN B-LF
- NOUN I-LF
associated VERB I-LF
virus NOUN I-LF
( PUNCT B-O
AAV PROPN B-AC
) PUNCT B-O
serotype NOUN B-O
9 NUM B-O
particles NOUN B-O
encoding VERB B-O
CaMKII.iGluu NOUN B-O
. PUNCT B-O

WPRE NOUN B-O
- NOUN B-O
hGH NOUN B-O
[ PUNCT B-O
30 NUM B-O
] PUNCT B-O
. PUNCT B-O

Potato NOUN B-LF
dextrose NOUN I-LF
agar NOUN I-LF
( PUNCT B-O
PDA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
potato NOUN B-LF
dextrose NOUN I-LF
broth NOUN I-LF
( PUNCT B-O
PDB PROPN B-AC
) PUNCT B-O
were AUX B-O
purchased VERB B-O
from ADP B-O
Difco PROPN B-O
( PUNCT B-O
BD PROPN B-O
, PUNCT B-O
USA PROPN B-O
) PUNCT B-O
. PUNCT B-O

Calcium NOUN B-LF
carbonate NOUN I-LF
( PUNCT B-O
CaCO3 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
ethanol NOUN B-O
were AUX B-O
purchased VERB B-O
from ADP B-O
Systerm PROPN B-O
( PUNCT B-O
Selangor PROPN B-O
, PUNCT B-O
Malaysia PROPN B-O
) PUNCT B-O
. PUNCT B-O

Estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rates NOUN I-LF
( PUNCT B-O
eGFRs PROPN B-AC
) PUNCT B-O
were AUX B-O
calculated VERB B-O
using VERB B-O
the DET B-O
four NUM B-O
- PUNCT B-O
variable NOUN B-O
equation NOUN B-O
derived VERB B-O
from ADP B-O
the DET B-O
Modification PROPN B-LF
of ADP I-LF
Diet PROPN I-LF
in ADP I-LF
Renal PROPN I-LF
Disease PROPN I-LF
( PUNCT B-O
MDRD PROPN B-AC
) PUNCT B-O
Study PROPN B-O
. PUNCT B-O

We PRON B-O
used VERB B-O
the DET B-O
cross ADJ B-O
- PUNCT B-O
sectional ADJ B-O
data NOUN B-O
including VERB B-O
6,160 NUM B-O
oldest ADJ B-O
old ADJ B-O
( PUNCT B-O
aged ADJ B-O
80 NUM B-O
years NOUN B-O
old ADJ B-O
or CCONJ B-O
older ADJ B-O
) PUNCT B-O
from ADP B-O
the DET B-O
genetic ADJ B-O
substudy NOUN B-O
of ADP B-O
the DET B-O
Chinese PROPN B-LF
Longitudinal PROPN I-LF
Healthy PROPN I-LF
Longevity PROPN I-LF
Survey PROPN I-LF
( PUNCT B-O
CLHLS PROPN B-AC
) PUNCT B-O
which PRON B-O
is AUX B-O
a DET B-O
national ADJ B-O
wide ADJ B-O
cohort NOUN B-O
study NOUN B-O
that PRON B-O
began VERB B-O
in ADP B-O
1998 NUM B-O
with ADP B-O
follow VERB B-O
- PUNCT B-O
up ADP B-O
surveys NOUN B-O
every DET B-O
2–3 NUM B-O
years NOUN B-O
. PUNCT B-O

Surprisingly ADV B-O
, PUNCT B-O
although SCONJ B-O
IL-22 PROPN B-AC
activates VERB B-O
signal NOUN B-LF
transducer NOUN I-LF
and CCONJ I-LF
activator NOUN I-LF
of ADP I-LF
transcription NOUN I-LF
3 NUM I-LF
( PUNCT B-O
STAT3 PROPN B-AC
) PUNCT B-O
in ADP B-O
APC PROPN B-O
- PUNCT B-O
mutant ADJ B-O
cells NOUN B-O
, PUNCT B-O
STAT3 PROPN B-AC
target NOUN B-O
genes NOUN B-O
were AUX B-O
not PART B-O
induced VERB B-O
. PUNCT B-O

Hh PROPN B-AC
, PUNCT B-O
hedgehog NOUN B-LF
; PUNCT B-O
NRF2 PROPN B-AC
, PUNCT B-O
nuclear ADJ B-LF
factor NOUN I-LF
- PUNCT I-LF
erythroid NOUN I-LF
2 NUM I-LF
- PUNCT I-LF
like NOUN I-LF
2 NUM I-LF
IMCD3 PROPN B-AC
, PUNCT B-O
inner ADJ B-LF
medullary NOUN I-LF
collecting VERB I-LF
duct NOUN I-LF
; PUNCT B-O
Nb PROPN B-AC
, PUNCT B-O
nanobody NOUN B-LF
; PUNCT B-O
SMO PROPN B-O
, PUNCT B-O
Smoothened VERB B-O
. PUNCT B-O

Specifically ADV B-O
, PUNCT B-O
the DET B-O
non ADJ B-O
- ADJ B-O
HCC PROPN B-AC
participants NOUN B-O
included VERB B-O
123 NUM B-O
with ADP B-O
gastrointestinal ADJ B-O
tumour NOUN B-O
( PUNCT B-O
GIT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
73 NUM B-O
with ADP B-O
benign ADJ B-O
liver NOUN B-O
tumour NOUN B-O
( PUNCT B-O
BLT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
453 NUM B-O
with ADP B-O
liver NOUN B-O
cirrhosis NOUN B-O
, PUNCT B-O
27 NUM B-O
with ADP B-O
chronic ADJ B-LF
hepatitis NOUN I-LF
C NOUN I-LF
( PUNCT B-O
CHC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
86 NUM B-O
with ADP B-O
chronic ADJ B-LF
hepatitis NOUN I-LF
B NOUN I-LF
( PUNCT B-O
CHB PROPN B-AC
) PUNCT B-O
, PUNCT B-O
50 NUM B-O
with ADP B-O
benign ADJ B-LF
gastrointestinal ADJ I-LF
disease NOUN I-LF
( PUNCT B-O
BGID PROPN B-AC
) PUNCT B-O
and CCONJ B-O
295 NUM B-O
healthy ADJ B-O
people NOUN B-O
. PUNCT B-O

To PART B-O
generate VERB B-O
null ADJ B-O
alleles NOUN B-O
, PUNCT B-O
we PRON B-O
sought VERB B-O
to PART B-O
create VERB B-O
mutants NOUN B-O
with ADP B-O
large ADJ B-O
fragment NOUN B-O
deletions NOUN B-O
by ADP B-O
designing VERB B-O
2 NUM B-O
single ADJ B-LF
guide NOUN I-LF
RNAs NOUN I-LF
( PUNCT B-O
sgRNAs PROPN B-AC
) PUNCT B-O
within ADP B-O
or CCONJ B-O
flanking VERB B-O
the DET B-O
stem NOUN B-O
- PUNCT B-O
loop NOUN B-O
region NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1B NUM B-O
) PUNCT B-O
. PUNCT B-O

Using VERB B-O
PCR NOUN B-O
genotyping NOUN B-O
, PUNCT B-O
we PRON B-O
successfully ADV B-O
identified VERB B-O
plants NOUN B-O
carrying VERB B-O
mutations NOUN B-O
in ADP B-O
every DET B-O
MIR172 PROPN B-O
family NOUN B-O
member NOUN B-O
in ADP B-O
the DET B-O
T1 PROPN B-O
generation NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1B NUM B-O
; PUNCT B-O
S1 PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

GP PROPN B-AC
, PUNCT B-O
EBOV NOUN B-LF
envelope NOUN I-LF
EBOV PROPN B-AC
glycoprotein NOUN I-LF
. PUNCT B-O

We PRON B-O
used VERB B-O
a DET B-O
specific ADJ B-O
antibody NOUN B-O
against ADP B-O
the DET B-O
promyelocytic ADJ B-LF
leukemia NOUN I-LF
( PUNCT B-O
PML PROPN B-AC
) PUNCT B-O
protein NOUN B-O
to PART B-O
study VERB B-O
the DET B-O
fate NOUN B-O
of ADP B-O
the DET B-O
PML PROPN B-AC
nuclear ADJ B-O
bodies NOUN B-O
, PUNCT B-O
which PRON B-O
are AUX B-O
well ADV B-O
- PUNCT B-O
characterized VERB B-O
subnuclear ADJ B-O
structures NOUN B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
parallel NOUN B-O
, PUNCT B-O
the DET B-O
rate NOUN B-O
of ADP B-O
Caesarean ADJ B-LF
section NOUN I-LF
( PUNCT B-O
C-Section PROPN B-AC
) PUNCT B-O
deliveries NOUN B-O
has AUX B-O
also ADV B-O
increased VERB B-O
dramatically ADV B-O
over ADP B-O
the DET B-O
last ADJ B-O
decades NOUN B-O
. PUNCT B-O

• PUNCT B-O
RLS PROPN B-AC
diagnosis NOUN B-O
was AUX B-O
made VERB B-O
on ADP B-O
the DET B-O
diagnostic ADJ B-O
criteria NOUN B-O
of ADP B-O
the DET B-O
International PROPN B-O
Restless PROPN B-LF
Legs PROPN I-LF
Syndrome PROPN I-LF
Study PROPN B-O
Group PROPN B-O
( PUNCT B-O
2010 NUM B-O
) PUNCT B-O
. PUNCT B-O

IQR PROPN B-AC
: PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
Similarly ADV B-O
, PUNCT B-O
assessment NOUN B-O
of ADP B-O
other ADJ B-O
quantitative ADJ B-O
variables NOUN B-O
is AUX B-O
essential ADJ B-O
in ADP B-O
pre- ADJ B-O
and CCONJ B-O
post ADJ B-O
- ADJ B-O
MI PROPN B-AC
conditions NOUN B-O
which PRON B-O
primarily ADV B-O
includes VERB B-O
, PUNCT B-O
plasma NOUN B-O
glucose NOUN B-O
levels NOUN B-O
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
high ADJ B-LF
density NOUN I-LF
lipid NOUN I-LF
( PUNCT B-O
HDL PROPN B-AC
) PUNCT B-O
, PUNCT B-O
low ADJ B-LF
density NOUN I-LF
lipid NOUN I-LF
( PUNCT B-O
LDL PROPN B-AC
) PUNCT B-O
and CCONJ B-O
triglycerides NOUN B-O
levels NOUN B-O
. PUNCT B-O

Fresh ADJ B-O
IBM PROPN B-O
suspended VERB B-O
in ADP B-O
0.1 NUM B-O
% PUNCT B-O
AKRB PROPN B-AC
were AUX B-O
centrifuged VERB B-O
for ADP B-O
15 NUM B-O
min NOUN B-O
at ADP B-O
800 NUM B-O
rpm NOUN B-O
and CCONJ B-O
immediately ADV B-O
suspended VERB B-O
in ADP B-O
2ml NUM B-O
of ADP B-O
Dulbecco PROPN B-LF
's PART I-LF
Modified PROPN I-LF
Eagle PROPN I-LF
's PART I-LF
( PUNCT B-O
DMEM PROPN B-AC
) PUNCT B-O
+ SYM B-O
BSA0.1 NUM B-O
% PUNCT B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
Tem PROPN B-AC
effects NOUN B-O
on ADP B-O
LC3-II PROPN B-AC
levels NOUN B-O
were AUX B-O
also ADV B-O
preserved VERB B-O
in ADP B-O
5 NUM B-LF
' NOUN I-LF
adenosine NOUN I-LF
monophosphate NOUN I-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT B-O
AMPK PROPN B-AC
) PUNCT B-O
α1 NUM B-O
/ SYM B-O
α2 NUM B-O
double ADJ B-O
KO PROPN B-AC
MEFs PROPN B-AC
( PUNCT B-O
S6B PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

Chronic ADJ B-O
HBV PROPN B-AC
infection NOUN B-O
was AUX B-O
classified VERB B-O
according VERB B-O
to ADP B-O
the DET B-O
latest ADJ B-O
European PROPN B-LF
Association PROPN I-LF
for ADP I-LF
the DET I-LF
Study PROPN I-LF
of ADP I-LF
the DET I-LF
Liver PROPN I-LF
( PUNCT B-O
EASL PROPN B-AC
) PUNCT B-O
Clinical PROPN B-LF
Practice PROPN I-LF
Guidelines PROPN I-LF
( PUNCT B-O
CPG PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
CI PROPN B-AC
, PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
TBI PROPN B-AC
, PUNCT B-O
traumatic ADJ B-LF
brain NOUN I-LF
injury NOUN I-LF
. PUNCT B-O

This DET B-O
study NOUN B-O
is AUX B-O
reported VERB B-O
as ADP B-O
per ADP B-O
the DET B-O
CONsolidated PROPN B-LF
Standards PROPN I-LF
of ADP I-LF
Reporting PROPN I-LF
Trials PROPN I-LF
( PUNCT B-O
CONSORT PROPN B-AC
) PUNCT B-O
( PUNCT B-O
S1 PROPN B-O
CONSORT PROPN B-AC
Checklist PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
risk NOUN B-O
of ADP B-O
ID PROPN B-AC
increases VERB B-O
during ADP B-O
pregnancy NOUN B-O
due ADP B-O
to PART B-O
an DET B-O
increase NOUN B-O
in ADP B-O
maternal ADJ B-O
iron NOUN B-O
requirements NOUN B-O
to PART B-O
accommodate VERB B-O
the DET B-O
expansion NOUN B-O
of ADP B-O
maternal ADJ B-O
red ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
( PUNCT B-O
RBC PROPN B-AC
) PUNCT B-O
mass NOUN B-O
, PUNCT B-O
development NOUN B-O
of ADP B-O
the DET B-O
placenta NOUN B-O
and CCONJ B-O
fetus NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
loss NOUN B-O
of ADP B-O
blood NOUN B-O
associated VERB B-O
with ADP B-O
labor NOUN B-O
and CCONJ B-O
delivery NOUN B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
is AUX B-O
reported VERB B-O
according VERB B-O
to ADP B-O
the DET B-O
Strengthening VERB B-LF
the DET I-LF
Reporting PROPN I-LF
of ADP I-LF
Observational PROPN I-LF
Studies PROPN I-LF
in ADP I-LF
Epidemiology PROPN I-LF
( PUNCT B-O
STROBE PROPN B-AC
) PUNCT B-O
statement NOUN B-O
( PUNCT B-O
S1 PROPN B-O
STROBE PROPN B-AC
Checklist PROPN B-O
) PUNCT B-O
. PUNCT B-O

Schematic ADJ B-O
pressure NOUN B-O
curve NOUN B-O
of ADP B-O
a DET B-O
BiPAP PROPN B-AC
ventilation NOUN B-O
( PUNCT B-O
A NOUN B-O
) PUNCT B-O
compared VERB B-O
to ADP B-O
ventilation NOUN B-O
in ADP B-O
PLBV PROPN B-AC
mode NOUN B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
. PUNCT B-O

BiPAP PROPN B-AC
: PUNCT B-O
Bilevel NOUN B-LF
positive ADJ I-LF
airway NOUN I-LF
pressure NOUN I-LF
; PUNCT B-O
IPAP PROPN B-AC
: PUNCT B-O
inspiratory ADJ B-LF
positive ADJ I-LF
airway NOUN I-LF
pressure NOUN I-LF
; PUNCT B-O
EPAP PROPN B-AC
: PUNCT B-O
expiratory ADJ B-LF
positive ADJ I-LF
airway NOUN I-LF
pressure NOUN I-LF
; PUNCT B-O
PLBV PROPN B-AC
: PUNCT B-O
pursed ADJ B-LF
lips NOUN I-LF
breathing VERB I-LF
ventilation NOUN I-LF
. PUNCT B-O

Sodium PROPN B-LF
Calcium PROPN I-LF
exchangers NOUN I-LF
( PUNCT B-O
NCX PROPN B-AC
) PUNCT B-O
are AUX B-O
low ADJ B-O
affinity NOUN B-O
high ADJ B-O
capacity NOUN B-O
( PUNCT B-O
kcat NOUN B-O
2000–5000 NUM B-O
s−1 NUM B-O
) PUNCT B-O
antiporters NOUN B-O
that PRON B-O
can AUX B-O
rapidly ADV B-O
move VERB B-O
Ca2 NOUN B-O
+ NOUN B-O
ions NOUN B-O
across ADP B-O
the DET B-O
plasma NOUN B-O
membrane NOUN B-O
. PUNCT B-O

Cells NOUN B-O
were AUX B-O
left VERB B-O
to PART B-O
expand VERB B-O
for ADP B-O
3–4 NUM B-O
consecutive ADJ B-O
days NOUN B-O
to PART B-O
form VERB B-O
a DET B-O
confluent ADJ B-O
monolayer NOUN B-O
( PUNCT B-O
unless SCONJ B-O
stated VERB B-O
otherwise ADV B-O
) PUNCT B-O
before SCONJ B-O
fixation NOUN B-O
with ADP B-O
4 NUM B-O
% NOUN B-O
paraformaldehyde NOUN B-LF
( PUNCT B-O
PFA PROPN B-AC
) PUNCT B-O
was AUX B-O
performed VERB B-O
. PUNCT B-O

Moreover ADV B-O
, PUNCT B-O
HIF-2α PROPN B-AC
– PUNCT B-O
dependent ADJ B-O
up NOUN B-O
- PUNCT B-O
regulation NOUN B-O
of ADP B-O
interleukin NOUN B-LF
( PUNCT B-O
IL)-6 PROPN B-AC
in ADP B-O
FLS PROPN B-AC
stimulated VERB B-O
differentiation NOUN B-O
of ADP B-O
TH17 NOUN B-O
cells NOUN B-O
— PUNCT B-O
crucial ADJ B-O
effectors NOUN B-O
of ADP B-O
RA PROPN B-AC
pathogenesis NOUN B-O
. PUNCT B-O

We PRON B-O
tested VERB B-O
2 NUM B-O
low ADJ B-O
- PUNCT B-O
intensity NOUN B-O
versions NOUN B-O
of ADP B-O
CBT PROPN B-AC
in ADP B-O
a DET B-O
trial NOUN B-O
( PUNCT B-O
guided VERB B-O
self NOUN B-O
- PUNCT B-O
help NOUN B-O
and CCONJ B-O
supported VERB B-O
computerised ADJ B-LF
cognitive ADJ I-LF
- PUNCT I-LF
behaviour NOUN I-LF
therapy NOUN I-LF
[ PUNCT B-O
cCBT PROPN B-AC
] PUNCT B-O
) PUNCT B-O
, PUNCT B-O
testing VERB B-O
their PRON B-O
impact NOUN B-O
on ADP B-O
patients NOUN B-O
with ADP B-O
OCD PROPN B-AC
when SCONJ B-O
provided VERB B-O
prior ADV B-O
to ADP B-O
CBT PROPN B-AC
with ADP B-O
a DET B-O
therapist NOUN B-O
. PUNCT B-O

The DET B-O
pelvic ADJ B-O
inlet NOUN B-O
anterior ADJ B-LF
- PUNCT I-LF
posterior ADJ I-LF
diameter NOUN I-LF
( PUNCT B-O
APD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
also ADV B-O
called VERB B-O
the DET B-O
obstetric ADJ B-O
conjugate NOUN B-O
, PUNCT B-O
was AUX B-O
measured VERB B-O
from ADP B-O
the DET B-O
anterior ADJ B-O
cortical ADJ B-O
surface NOUN B-O
of ADP B-O
the DET B-O
sacrovertebral ADJ B-O
angel NOUN B-O
( PUNCT B-O
promontory NOUN B-O
) PUNCT B-O
to ADP B-O
the DET B-O
closest ADJ B-O
point NOUN B-O
on ADP B-O
the DET B-O
convex ADJ B-O
posterior ADJ B-O
- PUNCT B-O
superior ADJ B-O
aspect NOUN B-O
of ADP B-O
the DET B-O
pubis NOUN B-O
symphysis NOUN B-O
. PUNCT B-O

By ADP B-O
contrast NOUN B-O
, PUNCT B-O
enhanced VERB B-O
green ADJ B-O
- PUNCT B-O
fusion NOUN B-O
protein NOUN B-O
- PUNCT B-O
maximakinin NOUN B-LF
( PUNCT B-O
EGFP PROPN B-AC
- PUNCT B-O
MK PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
much ADV B-O
brighter ADJ B-O
, PUNCT B-O
nanomolar ADJ B-O
affinity NOUN B-O
agonist NOUN B-O
of ADP B-O
the DET B-O
rabbit NOUN B-O
B2R PROPN B-AC
that PRON B-O
does AUX B-O
not PART B-O
bind VERB B-O
to ADP B-O
ACE PROPN B-AC
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

Currently ADV B-O
there PRON B-O
is VERB B-O
no DET B-O
standard ADJ B-O
second ADJ B-O
- PUNCT B-O
line NOUN B-O
treatment NOUN B-O
for ADP B-O
steroid NOUN B-LF
- PUNCT I-LF
refractory ADJ I-LF
aGVHD PROPN B-AC
( PUNCT B-O
SR PROPN B-AC
- PUNCT B-O
aGVHD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Numerous ADJ B-O
strategies NOUN B-O
to PART B-O
treat VERB B-O
SR PROPN B-AC
- PUNCT B-O
aGVHD PROPN B-AC
have AUX B-O
been AUX B-O
reported VERB B-O
, PUNCT B-O
but CCONJ B-O
results NOUN B-O
have AUX B-O
been AUX B-O
disappointing ADJ B-O
with ADP B-O
varying VERB B-O
response NOUN B-O
rates NOUN B-O
and CCONJ B-O
long ADJ B-O
term NOUN B-O
overall ADJ B-LF
survival NOUN I-LF
( PUNCT B-O
OS PROPN B-AC
) PUNCT B-O
of ADP B-O
only ADV B-O
20–30 NUM B-O
% NOUN B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

Raw ADJ B-O
data NOUN B-O
for ADP B-O
panels NOUN B-O
A NOUN B-O
and CCONJ B-O
B NOUN B-O
can AUX B-O
be AUX B-O
found VERB B-O
in ADP B-O
the DET B-O
Supporting NOUN B-O
Information NOUN B-O
section NOUN B-O
S2 NOUN B-O
Data NOUN B-O
file NOUN B-O
. PUNCT B-O

fMLP PROPN B-AC
, PUNCT B-O
N NOUN B-LF
- PUNCT I-LF
formylMethionyl NOUN I-LF
- PUNCT I-LF
Leucyl NOUN I-LF
- PUNCT I-LF
Phenylalanine NOUN I-LF
; PUNCT B-O
KD PROPN B-AC
, PUNCT B-O
knockdown NOUN B-LF
; PUNCT B-O
NSshRNA PROPN B-AC
, PUNCT B-O
nonspecific ADJ B-LF
shRNA NOUN I-LF
shRNA PROPN B-AC
. PUNCT B-O

To PART B-O
determine VERB B-O
whether SCONJ B-O
this DET B-O
inflammatory ADJ B-O
response NOUN B-O
is AUX B-O
reflected VERB B-O
by ADP B-O
up NOUN B-O
- ADJ B-O
regulation NOUN B-O
of ADP B-O
pro ADJ B-O
- ADJ B-O
inflammatory ADJ B-O
markers NOUN B-O
, PUNCT B-O
we PRON B-O
performed VERB B-O
reverse ADJ B-LF
transcription NOUN I-LF
PCR NOUN I-LF
( PUNCT B-O
RT-PCR PROPN B-AC
) PUNCT B-O
on ADP B-O
larvae NOUN B-O
carrying VERB B-O
a DET B-O
transformed VERB B-O
goblet NOUN B-O
cell NOUN B-O
burden NOUN B-O
, PUNCT B-O
and CCONJ B-O
indeed ADV B-O
we PRON B-O
see VERB B-O
increased VERB B-O
levels NOUN B-O
of ADP B-O
tnfα NOUN B-O
, PUNCT B-O
cxcl1 NOUN B-O
, PUNCT B-O
il8 NOUN B-O
, PUNCT B-O
ifn1 NOUN B-O
, PUNCT B-O
and CCONJ B-O
il1β NOUN B-O
in ADP B-O
these DET B-O
larvae NOUN B-O
( PUNCT B-O
Figure NOUN B-O
S1A NOUN B-O
) PUNCT B-O
. PUNCT B-O

Moreover ADV B-O
, PUNCT B-O
if SCONJ B-O
we PRON B-O
look VERB B-O
by ADP B-O
quantitative ADJ B-LF
PCR NOUN I-LF
( PUNCT B-O
qPCR PROPN B-AC
) PUNCT B-O
at ADP B-O
levels NOUN B-O
of ADP B-O
two NUM B-O
of ADP B-O
these DET B-O
genes NOUN B-O
, PUNCT B-O
il1β NOUN B-O
and CCONJ B-O
cxcl1 NOUN B-O
, PUNCT B-O
we PRON B-O
see VERB B-O
their PRON B-O
clear ADJ B-O
induction NOUN B-O
in ADP B-O
larvae NOUN B-O
where SCONJ B-O
V12RAS NOUN B-O
expression NOUN B-O
is AUX B-O
induced VERB B-O
by ADP B-O
heat NOUN B-O
shock NOUN B-O
only ADV B-O
6 NUM B-O
h NOUN B-O
before ADP B-O
RNA NOUN B-O
extraction NOUN B-O
, PUNCT B-O
suggesting VERB B-O
that SCONJ B-O
pro ADJ B-O
- ADJ B-O
inflammatory ADJ B-O
gene NOUN B-O
expression NOUN B-O
is AUX B-O
a DET B-O
rapid ADJ B-O
response NOUN B-O
to ADP B-O
V12RAS NOUN B-O
expression NOUN B-O
( PUNCT B-O
Figure NOUN B-O
S1B NOUN B-O
) PUNCT B-O
. PUNCT B-O

Replacing VERB B-O
NNRTIs PROPN B-AC
by ADP B-O
dolutegravir PROPN B-LF
( PUNCT B-O
DTG PROPN B-AC
) PUNCT B-O
may AUX B-O
curb VERB B-O
the DET B-O
spread NOUN B-O
of ADP B-O
resistance NOUN B-O
, PUNCT B-O
but CCONJ B-O
it PRON B-O
is AUX B-O
unclear ADJ B-O
how SCONJ B-O
effective ADJ B-O
this DET B-O
switch NOUN B-O
will AUX B-O
be AUX B-O
and CCONJ B-O
which DET B-O
patient NOUN B-O
groups NOUN B-O
should AUX B-O
be AUX B-O
switched VERB B-O
from ADP B-O
NNRTI PROPN B-AC
to ADP B-O
DTG PROPN B-AC
. PUNCT B-O

Transcriptome ADJ B-O
sequencing NOUN B-O
analysis NOUN B-O
detected VERB B-O
106 NUM B-O
differentially ADV B-LF
expressed VERB I-LF
genes NOUN I-LF
( PUNCT B-O
DEGs PROPN B-AC
) PUNCT B-O
related VERB B-O
to ADP B-O
oxidative ADJ B-O
stress NOUN B-O
. PUNCT B-O

Finally ADV B-O
, PUNCT B-O
demographic ADJ B-O
information NOUN B-O
was AUX B-O
collected VERB B-O
, PUNCT B-O
including VERB B-O
the DET B-O
Integrated PROPN B-LF
Systematic PROPN I-LF
Care PROPN I-LF
for ADP I-LF
Older PROPN I-LF
People PROPN I-LF
( PUNCT B-O
ISCOPE PROPN B-AC
) PUNCT B-O
questionnaire NOUN B-O
, PUNCT B-O
to PART B-O
determine VERB B-O
complex ADJ B-O
health NOUN B-O
problems NOUN B-O
in ADP B-O
the DET B-O
participants NOUN B-O
[ PUNCT B-O
35 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
chicken NOUN B-O
appears VERB B-O
to PART B-O
lack VERB B-O
the DET B-O
ortholog NOUN B-O
for ADP B-O
the DET B-O
human ADJ B-O
GABABR PROPN B-AC
( PUNCT B-O
gamma NOUN B-LF
aminobutyric ADJ I-LF
acid NOUN I-LF
– PUNCT I-LF
binding VERB I-LF
receptor NOUN I-LF
) PUNCT B-O
1 NUM B-O
. PUNCT B-O

Mice NOUN B-O
8–10 NUM B-O
weeks NOUN B-O
old ADJ B-O
infected VERB B-O
intraperitoneally ADV B-O
with ADP B-O
102 NUM B-O
( PUNCT B-O
A&E NOUN B-O
) PUNCT B-O
, PUNCT B-O
103 NUM B-O
( PUNCT B-O
B&F NOUN B-O
) PUNCT B-O
, PUNCT B-O
104 NUM B-O
( PUNCT B-O
C&G NOUN B-O
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
106 NUM B-O
( PUNCT B-O
D&H NOUN B-O
) PUNCT B-O
plaque NOUN B-O
forming VERB B-O
units NOUN B-O
( PUNCT B-O
pfu NOUN B-O
) PUNCT B-O
Smith PROPN B-O
strain NOUN B-O
mCMV PROPN B-AC
had VERB B-O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT B-O
PBMC PROPN B-AC
) PUNCT B-O
evaluated VERB B-O
16 NUM B-O
weeks NOUN B-O
after ADP B-O
infection NOUN B-O
for ADP B-O
inflationary ADJ B-O
mCMV PROPN B-AC
- PUNCT B-O
specific ADJ B-O
T NOUN B-O
- PUNCT B-O
cells NOUN B-O
. PUNCT B-O

Error NOUN B-O
bars NOUN B-O
were AUX B-O
equal ADJ B-O
to ADP B-O
the DET B-O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
( PUNCT B-O
SEM PROPN B-AC
) PUNCT B-O
of ADP B-O
a DET B-O
subset NOUN B-O
of ADP B-O
the DET B-O
local ADJ B-O
UIs PROPN B-AC
. PUNCT B-O

The DET B-O
subset NOUN B-O
was AUX B-O
chosen VERB B-O
so SCONJ B-O
that SCONJ B-O
no DET B-O
two NUM B-O
triangles NOUN B-O
shared VERB B-O
an DET B-O
edge NOUN B-O
, PUNCT B-O
ensuring VERB B-O
that SCONJ B-O
local ADJ B-O
correlations NOUN B-O
in ADP B-O
the DET B-O
UI PROPN B-AC
did AUX B-O
not PART B-O
artificially ADV B-O
reduce VERB B-O
the DET B-O
SEM PROPN B-AC
. PUNCT B-O

The DET B-O
SEM PROPN B-AC
was AUX B-O
validated VERB B-O
using VERB B-O
a DET B-O
bootstrap NOUN B-O
simulation NOUN B-O
. PUNCT B-O

We PRON B-O
find VERB B-O
that SCONJ B-O
parasites NOUN B-O
undergoing VERB B-O
delayed VERB B-O
death NOUN B-O
exhibited VERB B-O
disrupted VERB B-O
prenylation NOUN B-O
of ADP B-O
proteins NOUN B-O
required VERB B-O
for ADP B-O
haemoglobin NOUN B-O
uptake NOUN B-O
and CCONJ B-O
the DET B-O
biogenesis NOUN B-O
of ADP B-O
the DET B-O
digestive ADJ B-LF
vacuole NOUN I-LF
( PUNCT B-O
DV PROPN B-AC
) PUNCT B-O
. PUNCT B-O

We PRON B-O
further ADV B-O
demonstrate VERB B-O
defective ADJ B-O
localisation NOUN B-O
of ADP B-O
prenylated VERB B-O
trafficking NOUN B-O
mediators NOUN B-O
, PUNCT B-O
defective ADJ B-O
uptake NOUN B-O
of ADP B-O
haemoglobin NOUN B-O
, PUNCT B-O
and CCONJ B-O
a DET B-O
disrupted VERB B-O
DV PROPN B-AC
in ADP B-O
these DET B-O
parasites NOUN B-O
. PUNCT B-O

Tuberculosis NOUN B-LF
( PUNCT B-O
TB PROPN B-AC
) PUNCT B-O
is AUX B-O
one NUM B-O
of ADP B-O
the DET B-O
leading VERB B-O
causes NOUN B-O
of ADP B-O
death NOUN B-O
from ADP B-O
infectious ADJ B-O
disease NOUN B-O
worldwide ADV B-O
, PUNCT B-O
and CCONJ B-O
it PRON B-O
kills VERB B-O
around ADV B-O
1.7 NUM B-O
million NUM B-O
people NOUN B-O
each DET B-O
year NOUN B-O
. PUNCT B-O

In ADP B-O
brief NOUN B-O
, PUNCT B-O
a DET B-O
simplified ADJ B-O
form NOUN B-O
of ADP B-O
sepsis NOUN B-LF
- PUNCT I-LF
related VERB I-LF
organ NOUN B-LF
failure NOUN I-LF
assessment NOUN I-LF
( PUNCT B-O
SOFA PROPN B-AC
) PUNCT B-O
score NOUN B-O
[ PUNCT B-O
23]-based VERB B-O
scoring NOUN B-O
system NOUN B-O
, PUNCT B-O
the DET B-O
CLIF-C PROPN B-AC
OF PROPN B-AC
score NOUN B-O
, PUNCT B-O
was AUX B-O
used VERB B-O
to PART B-O
evaluate VERB B-O
OF PROPN B-AC
. PUNCT B-O

The DET B-O
CLIF PROPN B-AC
-CACLF PROPN B-AC
score NOUN B-O
was AUX B-O
developed VERB B-O
by ADP B-O
combining VERB B-O
the DET B-O
CLIF PROPN B-AC
-COF PROPN B-AC
score NOUN B-O
and CCONJ B-O
two NUM B-O
other ADJ B-O
independent ADJ B-O
prognostic ADJ B-O
factors NOUN B-O
, PUNCT B-O
age NOUN B-O
, PUNCT B-O
and CCONJ B-O
white ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
( PUNCT B-O
WBC PROPN B-AC
) PUNCT B-O
count NOUN B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
three NUM B-O
- ADJ B-O
parameter NOUN B-O
model NOUN B-O
that PRON B-O
did AUX B-O
not PART B-O
incorporate VERB B-O
inter ADJ B-O
- ADJ B-O
item ADJ B-O
homogeneity NOUN B-O
( PUNCT B-O
as SCONJ B-O
shown VERB B-O
in ADP B-O
Figure NOUN B-O
8A NUM B-O
) PUNCT B-O
accounted VERB B-O
for ADP B-O
only ADV B-O
51 NUM B-O
% NOUN B-O
of ADP B-O
the DET B-O
variance NOUN B-O
( PUNCT B-O
r NOUN B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
had VERB B-O
an DET B-O
Akaike PROPN B-LF
information NOUN I-LF
criterion NOUN I-LF
( PUNCT B-O
AIC PROPN B-AC
) PUNCT B-O
value NOUN B-O
( PUNCT B-O
see VERB B-O
Methods NOUN B-O
) PUNCT B-O
of ADP B-O
1,010 NUM B-O
( PUNCT B-O
higher ADJ B-O
AIC PROPN B-AC
values NOUN B-O
indicate VERB B-O
worse ADJ B-O
fit NOUN B-O
[ X B-O
27 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

D13 NOUN B-O
, PUNCT B-O
diploid ADJ B-O
cycle NOUN B-O
13 NUM B-O
embryos NOUN B-O
; PUNCT B-O
eve2 PROPN B-AC
, PUNCT B-O
even ADV B-LF
skipped VERB I-LF
stripe NOUN I-LF
2 NUM I-LF
; PUNCT B-O
Frs PROPN B-AC
, PUNCT B-O
Frühstart NOUN B-LF
; PUNCT B-O
H14 NOUN B-O
, PUNCT B-O
haploid ADJ B-O
cycle NOUN B-O
14 NUM B-O
embryos NOUN B-O
; PUNCT B-O
kni PROPN B-AC
, PUNCT B-O
knirps NOUN B-LF
; PUNCT B-O
N PROPN B-AC
, PUNCT B-O
ratio NOUN B-LF
of ADP I-LF
nuclei NOUN I-LF
to ADP I-LF
cytoplasm NOUN I-LF
; PUNCT B-O
PCNA PROPN B-O
, PUNCT B-O
proliferating VERB B-O
cell NOUN B-O
nuclear ADJ B-O
antigen NOUN B-O
. PUNCT B-O

We PRON B-O
ectopically ADV B-O
expressed VERB B-O
N. PROPN B-O
crassa NOUN B-O
Puf3 PROPN B-O
protein NOUN B-O
fused VERB B-O
to ADP B-O
a DET B-O
tandem NOUN B-LF
affinity NOUN I-LF
purification NOUN I-LF
tag NOUN I-LF
( PUNCT B-O
TAP-tag PROPN B-AC
) PUNCT B-O
in ADP B-O
a DET B-O
S. PROPN B-O
cerevisiae NOUN B-O
strain NOUN B-O
missing VERB B-O
endogenous ADJ B-O
Puf PROPN B-AC
proteins NOUN B-O
, PUNCT B-O
Puf1 PROPN B-O
- PUNCT B-O
5 NUM B-O
( PUNCT B-O
derived VERB B-O
from ADP B-O
5Δpufs NOUN B-O
strain NOUN B-O
[ PUNCT B-O
47 NUM B-O
] PUNCT B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
we PRON B-O
identified VERB B-O
the DET B-O
RNAs NOUN B-O
bound VERB B-O
by ADP B-O
N. PROPN B-O
crassa NOUN B-O
Puf3 PROPN B-O
( PUNCT B-O
Materials NOUN B-O
and CCONJ B-O
Methods PROPN B-O
) PUNCT B-O
. PUNCT B-O

This DET B-O
periodicity NOUN B-O
was AUX B-O
evident ADJ B-O
when SCONJ B-O
we PRON B-O
aligned VERB B-O
all DET B-O
coding VERB B-O
regions NOUN B-O
to ADP B-O
the DET B-O
first ADJ B-O
nucleosome NOUN B-O
downstream ADV B-O
of ADP B-O
the DET B-O
TSS PROPN B-AC
and CCONJ B-O
ranked VERB B-O
all DET B-O
these DET B-O
genes NOUN B-O
by ADP B-O
a DET B-O
nucleosome NOUN B-LF
positioning NOUN I-LF
periodicity NOUN I-LF
( PUNCT B-O
NPP PROPN B-AC
) PUNCT B-O
score NOUN B-O
applied VERB B-O
to ADP B-O
the DET B-O
coding VERB B-O
region NOUN B-O
( PUNCT B-O
Figure NOUN B-O
3A NUM B-O
; PUNCT B-O
Materials NOUN B-O
and CCONJ B-O
Methods NOUN B-O
) PUNCT B-O
. PUNCT B-O

Therefore ADV B-O
, PUNCT B-O
the DET B-O
study NOUN B-O
aimed VERB B-O
to ADP B-O
suggest VERB B-O
the DET B-O
chemical ADJ B-O
composition NOUN B-O
of ADP B-O
C. PROPN B-O
obtusa PROPN B-O
leaf NOUN B-O
extract NOUN B-O
using VERB B-O
LC PROPN B-O
- PUNCT B-O
MS PROPN B-O
. PUNCT B-O

To PART B-O
assess VERB B-O
if SCONJ B-O
, PUNCT B-O
besides SCONJ B-O
the DET B-O
antioxidant ADJ B-O
activity NOUN B-O
, PUNCT B-O
C. PROPN B-O
obtusa PROPN B-O
would AUX B-O
exhibit VERB B-O
an DET B-O
anti ADJ B-O
aging ADJ B-O
effect NOUN B-O
and CCONJ B-O
which DET B-O
mechanisms NOUN B-O
would AUX B-O
be AUX B-O
involved VERB B-O
in ADP B-O
it PRON B-O
, PUNCT B-O
we PRON B-O
evaluated VERB B-O
the DET B-O
effect NOUN B-O
of ADP B-O
the DET B-O
extract NOUN B-O
on ADP B-O
keratinocytes NOUN B-O
and CCONJ B-O
fibroblasts NOUN B-O
exposed VERB B-O
to ADP B-O
UV PROPN B-AC
radiation NOUN B-O
and CCONJ B-O
analyzed VERB B-O
protein NOUN B-O
carbonyl NOUN B-O
, PUNCT B-O
collagen NOUN B-O
, PUNCT B-O
hyaluronic ADJ B-LF
acid NOUN I-LF
( PUNCT B-O
HA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
metalloproteinase-1 NOUN B-O
( PUNCT B-O
MMP-1 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
IL-1 NOUN B-O
β PUNCT B-O
and CCONJ B-O
IL-6 NOUN B-O
contents NOUN B-O
. PUNCT B-O

We PRON B-O
first ADV B-O
analyzed VERB B-O
differences NOUN B-O
between ADP B-O
wards NOUN B-O
on ADP B-O
the DET B-O
activity NOUN B-O
categories NOUN B-O
: PUNCT B-O
Direct PROPN B-LF
Patient PROPN I-LF
Care PROPN I-LF
( PUNCT B-O
DPC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Collective PROPN B-LF
Patient PROPN I-LF
Care PROPN I-LF
( PUNCT B-O
CPC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
General PROPN B-LF
Tasks PROPN I-LF
( PUNCT B-O
GT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Other ADJ B-LF
Tasks PROPN I-LF
( PUNCT B-O
OT PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Compositional ADJ B-O
analysis NOUN B-O
dictates VERB B-O
that SCONJ B-O
one NUM B-O
variable NOUN B-O
needs VERB B-O
to PART B-O
be AUX B-O
chosen VERB B-O
as ADP B-O
a DET B-O
reference NOUN B-O
variable NOUN B-O
, PUNCT B-O
to PART B-O
compare VERB B-O
the DET B-O
others NOUN B-O
against ADP B-O
. PUNCT B-O

Specifically ADV B-O
, PUNCT B-O
we PRON B-O
loaded VERB B-O
retinas NOUN B-O
using VERB B-O
the DET B-O
acetoxymethyl NOUN B-LF
ester NOUN I-LF
( PUNCT B-O
AM-ester PROPN B-AC
) PUNCT B-O
of ADP B-O
this DET B-O
dye NOUN B-O
( PUNCT B-O
see VERB B-O
Methods NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
then ADV B-O
we PRON B-O
mechanically ADV B-O
dissociated VERB B-O
individual ADJ B-O
rod NOUN B-O
photoreceptors NOUN B-O
and/or CCONJ B-O
OSs PROPN B-AC
. PUNCT B-O

We PRON B-O
viewed VERB B-O
the DET B-O
preparation NOUN B-O
using VERB B-O
IR PROPN B-AC
illumination NOUN B-O
at ADP B-O
750 NUM B-O
nm NOUN B-O
and CCONJ B-O
an DET B-O
IR PROPN B-AC
- PUNCT B-O
sensitive ADJ B-O
video NOUN B-O
camera NOUN B-O
attached VERB B-O
to ADP B-O
the DET B-O
microscope NOUN B-O
. PUNCT B-O

For ADP B-O
some DET B-O
years NOUN B-O
, PUNCT B-O
the DET B-O
maximum ADJ B-LF
relaxation NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
MRR PROPN B-AC
) PUNCT B-O
of ADP B-O
the DET B-O
inspiratory ADJ B-O
muscles NOUN B-O
has AUX B-O
been AUX B-O
used VERB B-O
as ADP B-O
an DET B-O
indirect ADJ B-O
marker NOUN B-O
of ADP B-O
fatigue NOUN B-O
and CCONJ B-O
overload NOUN B-O
of ADP B-O
the DET B-O
inspiratory ADJ B-O
muscles NOUN B-O
. PUNCT B-O

Zhang PROPN B-O
et PROPN B-O
al NOUN B-O
. PUNCT B-O

[ X B-O
16 X B-O
] X B-O
demonstrated VERB B-O
that SCONJ B-O
Shp2 PROPN B-O
controls VERB B-O
phosphorylation NOUN B-O
and CCONJ B-O
activation NOUN B-O
of ADP B-O
Src PROPN B-LF
family NOUN I-LF
kinases NOUN I-LF
( PUNCT B-O
SFKs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
in ADP B-O
that SCONJ B-O
SFK PROPN B-AC
activity NOUN B-O
is AUX B-O
reduced VERB B-O
in ADP B-O
the DET B-O
absence NOUN B-O
of ADP B-O
Shp2 PROPN B-O
, PUNCT B-O
due ADP B-O
to ADP B-O
hyperphosphorylation NOUN B-O
of ADP B-O
the DET B-O
inhibitory ADJ B-O
phosphorylation NOUN B-O
site NOUN B-O
. PUNCT B-O

PAM PROPN B-AC
, PUNCT B-O
protospacer NOUN B-LF
adjacent ADJ I-LF
motif NOUN I-LF
; PUNCT B-O
SpCas9 PROPN B-AC
, PUNCT B-O
Streptococcus NOUN B-LF
pyogenes NOUN I-LF
Cas9 PROPN I-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT B-O

Anthranilic ADJ B-LF
acid NOUN I-LF
( PUNCT B-O
AA PROPN B-AC
) PUNCT B-O
supplementation NOUN B-O
rescues VERB B-O
gut NOUN B-O
granule NOUN B-O
and CCONJ B-O
DF PROPN B-AC
. PUNCT B-O

( PUNCT B-O
A X B-O
, PUNCT B-O
B NOUN B-O
) PUNCT B-O
Incubation NOUN B-O
of ADP B-O
tdo-2(RNAi NOUN B-O
) PUNCT B-O
worms NOUN B-O
in ADP B-O
5 NUM B-O
mM PROPN B-O
AA PROPN B-AC
leads VERB B-O
to ADP B-O
gut NOUN B-O
granule NOUN B-O
fluorescence NOUN B-O
similar ADJ B-O
to ADP B-O
wild ADJ B-O
type NOUN B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Effect NOUN B-O
on ADP B-O
gut NOUN B-O
granule NOUN B-O
fluorescence NOUN B-O
of ADP B-O
incubation NOUN B-O
in ADP B-O
a DET B-O
range NOUN B-O
of ADP B-O
AA PROPN B-AC
concentrations NOUN B-O
. PUNCT B-O

5 NUM B-O
mM PROPN B-O
AA PROPN B-AC
gives VERB B-O
fluorescence NOUN B-O
levels NOUN B-O
similar ADJ B-O
to ADP B-O
wild ADJ B-O
type NOUN B-O
. PUNCT B-O

( PUNCT B-O
B NOUN B-O
) PUNCT B-O
Epifluorescence NOUN B-O
microscopy NOUN B-O
reveals VERB B-O
restoration NOUN B-O
of ADP B-O
gut NOUN B-O
granule NOUN B-O
fluorescence NOUN B-O
by ADP B-O
incubation NOUN B-O
in ADP B-O
5 NUM B-O
mM PROPN B-O
AA PROPN B-AC
. PUNCT B-O

( PUNCT B-O
C X B-O
, PUNCT B-O
D NOUN B-O
) PUNCT B-O
Incubation NOUN B-O
of ADP B-O
tdo-2(RNAi NOUN B-O
) PUNCT B-O
worms NOUN B-O
in ADP B-O
5 NUM B-O
mM PROPN B-O
AA PROPN B-AC
leads VERB B-O
to ADP B-O
DF PROPN B-AC
similar ADJ B-O
to ADP B-O
wild ADJ B-O
type NOUN B-O
. PUNCT B-O

( PUNCT B-O
C X B-O
) PUNCT B-O
Effects NOUN B-O
of ADP B-O
tdo-2(RNAi NOUN B-O
) PUNCT B-O
and CCONJ B-O
AA PROPN B-AC
supplementation NOUN B-O
on ADP B-O
peak ADJ B-O
DF PROPN B-AC
. PUNCT B-O

( PUNCT B-O
D NOUN B-O
) PUNCT B-O
Similar ADJ B-O
kinetics NOUN B-O
of ADP B-O
DF PROPN B-AC
in ADP B-O
control NOUN B-O
worms NOUN B-O
and CCONJ B-O
tdo-2(RNAi NOUN B-O
) PUNCT B-O
worms NOUN B-O
with ADP B-O
AA PROPN B-AC
- PUNCT B-O
replenished VERB B-O
gut NOUN B-O
granules NOUN B-O
, PUNCT B-O
even ADV B-O
though SCONJ B-O
only ADV B-O
the DET B-O
former ADJ B-O
can AUX B-O
synthesize VERB B-O
AA PROPN B-AC
. PUNCT B-O

Signal ADJ B-LF
transducer NOUN I-LF
and CCONJ I-LF
activator NOUN I-LF
of ADP I-LF
transcription NOUN I-LF
5b NOUN I-LF
( PUNCT B-O
STAT5b PROPN B-AC
) PUNCT B-O
is AUX B-O
one NUM B-O
of ADP B-O
seven NUM B-O
mammalian ADJ B-O
STAT PROPN B-O
transcription NOUN B-O
factors NOUN B-O
[ PUNCT B-O
1 NUM B-O
, PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

Oxidative ADJ B-O
stress NOUN B-O
refers VERB B-O
to PART B-O
the DET B-O
imbalance NOUN B-O
between ADP B-O
the DET B-O
products NOUN B-O
of ADP B-O
reactive ADJ B-LF
oxygen NOUN I-LF
species NOUN I-LF
( PUNCT B-O
ROS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
biological ADJ B-O
ability NOUN B-O
to PART B-O
detoxify VERB B-O
them PRON B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

U5 PROPN B-O
is AUX B-O
identical ADJ B-O
to ADP B-O
U3 PROPN B-O
except SCONJ B-O
that SCONJ B-O
it PRON B-O
lacks VERB B-O
the DET B-O
third ADJ B-O
randomized VERB B-O
ankyrin NOUN B-LF
repeat NOUN I-LF
( PUNCT B-O
AR PROPN B-AC
) PUNCT B-O
domain NOUN B-O
. PUNCT B-O

We PRON B-O
used VERB B-O
an DET B-O
iterative ADJ B-O
immuno ADJ B-O
- PUNCT B-O
FISH PROPN B-AC
( PUNCT B-O
fluorescence NOUN B-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
) PUNCT B-O
approach NOUN B-O
[ X B-O
41 X B-O
] X B-O
to ADP B-O
investigate VERB B-O
the DET B-O
organization NOUN B-O
of ADP B-O
the DET B-O
chromosome NOUN B-O
loops NOUN B-O
associated VERB B-O
with ADP B-O
pairs NOUN B-O
of ADP B-O
sister NOUN B-O
chromatids NOUN B-O
, PUNCT B-O
both PRON B-O
relative ADJ B-O
to ADP B-O
each DET B-O
other ADJ B-O
and CCONJ B-O
in ADP B-O
relationship NOUN B-O
to ADP B-O
the DET B-O
chromosome NOUN B-O
axis NOUN B-O
. PUNCT B-O

Historically ADV B-O
, PUNCT B-O
PJP PROPN B-AC
affects VERB B-O
mostly ADV B-O
patients NOUN B-O
with ADP B-O
human ADJ B-LF
immunodeficiency NOUN I-LF
virus NOUN I-LF
( PUNCT B-O
HIV PROPN B-AC
) PUNCT B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
prevalence NOUN B-O
of ADP B-O
patients NOUN B-O
with ADP B-O
HIV PROPN B-AC
- PUNCT B-O
related VERB B-O
PJP PROPN B-AC
has AUX B-O
decreased VERB B-O
with ADP B-O
the DET B-O
use NOUN B-O
of ADP B-O
highly ADV B-O
active ADJ B-O
antiretroviral ADJ B-O
therapy NOUN B-O
and CCONJ B-O
routine ADJ B-O
PJP PROPN B-AC
prophylaxis NOUN B-O
[ X B-O
1,2 NUM B-O
] PUNCT B-O
. PUNCT B-O

AID PROPN B-AC
, PUNCT B-O
auxin X B-LF
- PUNCT I-LF
inducible NOUN I-LF
degron PROPN I-LF
. PUNCT B-O

We PRON B-O
calculated VERB B-O
the DET B-O
GSCORR PROPN B-AC
under ADP B-O
three NUM B-O
procedures NOUN B-O
of ADP B-O
noise NOUN B-O
regression NOUN B-O
: PUNCT B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
without ADP B-O
any DET B-O
noise NOUN B-O
regression NOUN B-O
, PUNCT B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
regressors NOUN B-O
including VERB B-O
head NOUN B-O
motion NOUN B-O
and CCONJ B-O
signals NOUN B-O
from ADP B-O
the DET B-O
ventricle NOUN B-O
and CCONJ B-O
white ADJ B-O
matter NOUN B-O
as SCONJ B-O
well ADV B-O
as SCONJ B-O
their PRON B-O
first ADJ B-O
order NOUN B-O
derivatives NOUN B-O
, PUNCT B-O
( PUNCT B-O
3 X B-O
) PUNCT B-O
regressors NOUN B-O
including VERB B-O
those PRON B-O
in ADP B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
plus CCONJ B-O
the DET B-O
RVT PROPN B-AC
and CCONJ B-O
heart NOUN B-LF
rate NOUN I-LF
( PUNCT B-O
HR PROPN B-AC
) PUNCT B-O
. PUNCT B-O

If SCONJ B-O
the DET B-O
task NOUN B-O
modulation NOUN B-O
of ADP B-O
GSCORR PROPN B-AC
( PUNCT B-O
i.e. X B-O
, PUNCT B-O
ΔGSCORR NOUN B-O
) PUNCT B-O
was AUX B-O
driven VERB B-O
merely ADV B-O
by ADP B-O
noise NOUN B-O
, PUNCT B-O
then ADV B-O
its PRON B-O
spatial ADJ B-O
pattern NOUN B-O
, PUNCT B-O
as SCONJ B-O
calculated VERB B-O
without ADP B-O
noise NOUN B-O
, PUNCT B-O
should AUX B-O
show VERB B-O
low ADJ B-O
degrees NOUN B-O
of ADP B-O
spatial ADJ B-O
similarity NOUN B-O
with ADP B-O
the DET B-O
one NUM B-O
after ADP B-O
noise NOUN B-O
regression NOUN B-O
. PUNCT B-O

To PART B-O
overcome VERB B-O
the DET B-O
effects NOUN B-O
of ADP B-O
heterogeneous ADJ B-O
ELF5 PROPN B-O
induction NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1A NUM B-O
) PUNCT B-O
, PUNCT B-O
we PRON B-O
performed VERB B-O
intraductal ADJ B-O
allografts NOUN B-O
of ADP B-O
Fluorescence PROPN B-LF
- PUNCT I-LF
Activated VERB I-LF
Cell PROPN I-LF
Sorting PROPN I-LF
( PUNCT B-O
FACS)-sorted PROPN B-AC
( PUNCT B-O
Lin- PROPN B-O
and CCONJ B-O
CD24 PROPN B-O
+ PUNCT B-O
) PUNCT B-O
tumor NOUN B-O
cells NOUN B-O
that PRON B-O
were AUX B-O
either CCONJ B-O
EGFP PROPN B-O
( PUNCT B-O
ELF5 PROPN B-O
) PUNCT B-O
positive ADJ B-O
or CCONJ B-O
negative ADJ B-O
. PUNCT B-O

Recently ADV B-O
, PUNCT B-O
Anaplastic ADJ B-LF
Lymphoma PROPN I-LF
Kinase PROPN I-LF
( PUNCT B-O
ALK PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
receptor NOUN B-O
kinase NOUN B-O
involved VERB B-O
in ADP B-O
pro ADJ B-O
- ADJ B-O
survival ADJ B-O
signaling NOUN B-O
, PUNCT B-O
was AUX B-O
shown VERB B-O
to PART B-O
be AUX B-O
upregulated ADJ B-O
in ADP B-O
advanced ADJ B-O
/ SYM B-O
metastatic ADJ B-O
neuroblastomas NOUN B-O
[ PUNCT B-O
13 NUM B-O
, PUNCT B-O
14 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
the DET B-O
one NUM B-O
- PUNCT B-O
stage NOUN B-O
approach NOUN B-O
, PUNCT B-O
we PRON B-O
added VERB B-O
a DET B-O
second ADJ B-O
sensitivity NOUN B-O
analysis NOUN B-O
to PART B-O
compare VERB B-O
our PRON B-O
results NOUN B-O
against ADP B-O
those PRON B-O
of ADP B-O
a DET B-O
procedure NOUN B-O
applying VERB B-O
multiple ADJ B-O
imputation NOUN B-O
to PART B-O
include VERB B-O
all DET B-O
participants NOUN B-O
( PUNCT B-O
an DET B-O
intention NOUN B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
treat VERB I-LF
[ X B-O
ITT PROPN B-AC
] X B-O
analysis NOUN B-O
) PUNCT B-O
. PUNCT B-O

Previous ADJ B-O
work NOUN B-O
by ADP B-O
our PRON B-O
group NOUN B-O
reported VERB B-O
that SCONJ B-O
long ADJ B-O
- PUNCT B-O
term NOUN B-O
, PUNCT B-O
ambient ADJ B-O
PM PROPN B-AC
exposure NOUN B-O
induces VERB B-O
hepatic ADJ B-O
fibrosis NOUN B-O
and CCONJ B-O
increased VERB B-O
ROS NOUN B-O
production NOUN B-O
in ADP B-O
the DET B-O
liver NOUN B-O
in ADP B-O
mice NOUN B-O
; PUNCT B-O
the DET B-O
combination NOUN B-O
of ADP B-O
PM PROPN B-AC
exposure NOUN B-O
and CCONJ B-O
a DET B-O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
( PUNCT B-O
HFD PROPN B-AC
) PUNCT B-O
aggravates VERB B-O
hepatic ADJ B-O
fibrosis NOUN B-O
[ PUNCT B-O
11 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
subsidy NOUN B-O
level NOUN B-O
of ADP B-O
30 NUM B-O
% NOUN B-O
was AUX B-O
based VERB B-O
on ADP B-O
the DET B-O
subsidy NOUN B-O
level NOUN B-O
used VERB B-O
in ADP B-O
the DET B-O
US PROPN B-O
Department PROPN B-O
of ADP B-O
Agriculture PROPN B-O
’s PART B-O
( PUNCT B-O
USDA PROPN B-AC
’s PART B-O
) PUNCT B-O
Healthy PROPN B-LF
Incentives PROPN I-LF
Pilot PROPN I-LF
( PUNCT B-O
HIP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
randomized ADJ B-O
controlled ADJ B-O
trial NOUN B-O
implemented VERB B-O
among ADP B-O
Supplemental PROPN B-LF
Nutrition PROPN I-LF
Assistant PROPN I-LF
Program PROPN I-LF
( PUNCT B-O
SNAP PROPN B-AC
) PUNCT B-O
participants NOUN B-O
to PART B-O
incentivize VERB B-O
F&V PROPN B-AC
consumption NOUN B-O
[ PUNCT B-O
37 NUM B-O
] PUNCT B-O
. PUNCT B-O

This PRON B-O
is AUX B-O
of ADP B-O
particular ADJ B-O
relevance NOUN B-O
because SCONJ B-O
obesity NOUN B-O
is AUX B-O
a DET B-O
risk NOUN B-O
factor NOUN B-O
for ADP B-O
a DET B-O
number NOUN B-O
of ADP B-O
cancer NOUN B-O
types NOUN B-O
, PUNCT B-O
including VERB B-O
multiple ADJ B-LF
myeloma NOUN I-LF
( PUNCT B-O
MM PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

During ADP B-O
the DET B-O
past NOUN B-O
decade NOUN B-O
, PUNCT B-O
large ADJ B-O
- PUNCT B-O
scale NOUN B-O
implementation NOUN B-O
of ADP B-O
long ADV B-LF
- PUNCT I-LF
lasting VERB I-LF
insecticidal ADJ I-LF
nets NOUN I-LF
( PUNCT B-O
LLINs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
indoor ADJ B-LF
residual ADJ I-LF
spraying NOUN I-LF
( PUNCT B-O
IRS PROPN B-AC
) PUNCT B-O
has AUX B-O
played VERB B-O
a DET B-O
major ADJ B-O
role NOUN B-O
in ADP B-O
reducing VERB B-O
malaria NOUN B-O
morbidity NOUN B-O
and CCONJ B-O
mortality NOUN B-O
in ADP B-O
Africa PROPN B-O
south ADV B-O
of ADP B-O
the DET B-O
Sahara PROPN B-O
[ PUNCT B-O
2 NUM B-O
, PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Data NOUN B-O
represent VERB B-O
the DET B-O
concentrations NOUN B-O
of ADP B-O
cytokines NOUN B-O
IL-1α PROPN B-AC
, PUNCT B-O
IL-1β PROPN B-AC
, PUNCT B-O
IL-6 PROPN B-AC
and CCONJ B-O
IL-10 PROPN B-AC
in ADP B-O
infants NOUN B-O
with ADP B-O
confirmed VERB B-O
late ADJ B-LF
- PUNCT I-LF
onset NOUN I-LF
sepsis NOUN I-LF
( PUNCT B-O
LOS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
possible ADJ B-O
LOS PROPN B-AC
and CCONJ B-O
no DET B-O
LOS PROPN B-AC
. PUNCT B-O

The DET B-O
box NOUN B-O
plots NOUN B-O
show VERB B-O
the DET B-O
median ADJ B-O
and CCONJ B-O
interquartile ADJ B-O
range NOUN B-O
and CCONJ B-O
statistically ADV B-O
significant ADJ B-O
differences NOUN B-O
based VERB B-O
on ADP B-O
the DET B-O
Mann PROPN B-O
- PUNCT B-O
Whitney PROPN B-O
Test PROPN B-O
( PUNCT B-O
* PUNCT B-O
, PUNCT B-O
p<0.05 NUM B-O
and CCONJ B-O
* PUNCT B-O
* PUNCT B-O
, PUNCT B-O
p<0.005 NUM B-O
) PUNCT B-O
. PUNCT B-O

From ADP B-O
a DET B-O
societal ADJ B-O
perspective NOUN B-O
including VERB B-O
informal ADJ B-O
healthcare NOUN B-O
costs NOUN B-O
and CCONJ B-O
lost VERB B-O
productivity NOUN B-O
, PUNCT B-O
respective ADJ B-O
ICERs PROPN B-AC
were AUX B-O
$ SYM B-O
14,576 NUM B-O
/ SYM B-O
QALY PROPN B-AC
and CCONJ B-O
$ SYM B-O
9,497 NUM B-O
/ SYM B-O
QALY PROPN B-AC
. PUNCT B-O

Results NOUN B-O
were AUX B-O
robust ADJ B-O
in ADP B-O
probabilistic ADJ B-O
sensitivity NOUN B-O
analyses NOUN B-O
and CCONJ B-O
a DET B-O
range NOUN B-O
of ADP B-O
one NUM B-O
- PUNCT B-O
way NOUN B-O
sensitivity NOUN B-O
and CCONJ B-O
subgroup NOUN B-O
analyses NOUN B-O
, PUNCT B-O
including VERB B-O
by ADP B-O
different ADJ B-O
durations NOUN B-O
of ADP B-O
the DET B-O
intervention NOUN B-O
( PUNCT B-O
5 NUM B-O
, PUNCT B-O
10 NUM B-O
, PUNCT B-O
and CCONJ B-O
20 NUM B-O
years NOUN B-O
and CCONJ B-O
lifetime NOUN B-O
) PUNCT B-O
, PUNCT B-O
food NOUN B-O
subsidy NOUN B-O
levels NOUN B-O
( PUNCT B-O
20 NUM B-O
% PUNCT B-O
, PUNCT B-O
50 NUM B-O
% PUNCT B-O
) PUNCT B-O
, PUNCT B-O
insurance NOUN B-O
groups NOUN B-O
( PUNCT B-O
Medicare PROPN B-O
, PUNCT B-O
Medicaid PROPN B-O
, PUNCT B-O
and CCONJ B-O
dual ADJ B-O
- PUNCT B-O
eligible ADJ B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
beneficiary NOUN B-O
characteristics NOUN B-O
within ADP B-O
each DET B-O
insurance NOUN B-O
group NOUN B-O
( PUNCT B-O
age NOUN B-O
, PUNCT B-O
race NOUN B-O
/ SYM B-O
ethnicity NOUN B-O
, PUNCT B-O
education NOUN B-O
, PUNCT B-O
income NOUN B-O
, PUNCT B-O
and CCONJ B-O
Supplemental PROPN B-LF
Nutrition PROPN I-LF
Assistant PROPN I-LF
Program PROPN I-LF
[ PUNCT B-O
SNAP PROPN B-AC
] PUNCT B-O
status NOUN B-O
) PUNCT B-O
. PUNCT B-O

t NOUN B-O
: PUNCT B-O
endoscopic ADJ B-LF
papillary ADJ I-LF
balloon NOUN I-LF
dilatation NOUN I-LF
duration NOUN B-O
time NOUN B-O
, PUNCT B-O
N NOUN B-O
: PUNCT B-O
number NOUN B-O
, PUNCT B-O
BMI PROPN B-O
: PUNCT B-O
body NOUN B-O
mass NOUN B-O
index NOUN B-O
, PUNCT B-O
BW PROPN B-O
: PUNCT B-O
body NOUN B-O
weight NOUN B-O
, PUNCT B-O
CV PROPN B-O
: PUNCT B-O
cardiovascular ADJ B-O
, PUNCT B-O
CM PROPN B-O
: PUNCT B-O
chest NOUN B-O
, PUNCT B-O
DM PROPN B-O
: PUNCT B-O
diabetes NOUN B-O
mellitus NOUN B-O
, PUNCT B-O
SBP PROPN B-O
: PUNCT B-O
systolic ADJ B-O
blood NOUN B-O
pressure NOUN B-O
, PUNCT B-O
BT PROPN B-O
: PUNCT B-O
body NOUN B-O
temperature NOUN B-O
, PUNCT B-O
HR NOUN B-O
: PUNCT B-O
heart NOUN B-O
rate NOUN B-O
, PUNCT B-O
RR PROPN B-O
: PUNCT B-O
respiratory ADJ B-O
rate NOUN B-O
, PUNCT B-O
WBC PROPN B-O
: PUNCT B-O
white ADJ B-O
blood NOUN B-O
cell NOUN B-O
count NOUN B-O
, PUNCT B-O
Hb PROPN B-O
: PUNCT B-O
hemoglobin NOUN B-O
, PUNCT B-O
PLT PROPN B-O
: PUNCT B-O
platelet NOUN B-O
, PUNCT B-O
INR PROPN B-O
: PUNCT B-O
international ADJ B-O
normalized VERB B-O
ratio NOUN B-O
, PUNCT B-O
ALT PROPN B-O
: PUNCT B-O
alanine NOUN B-O
aminotransferase NOUN B-O
, PUNCT B-O
AST PROPN B-O
: PUNCT B-O
aspartate NOUN B-O
aminotransferase NOUN B-O
, PUNCT B-O
BUN PROPN B-O
: PUNCT B-O
blood NOUN B-O
urea NOUN B-O
nitrogen NOUN B-O
, PUNCT B-O
Cr PROPN B-O
: PUNCT B-O
creatinine NOUN B-O
, PUNCT B-O
ALP PROPN B-O
: PUNCT B-O
alkaline NOUN B-O
phosphatase NOUN B-O
, PUNCT B-O
rGT PROPN B-O
: PUNCT B-O
gamma NOUN B-O
- PUNCT B-O
glutamyl NOUN B-O
transpeptidase NOUN B-O
, PUNCT B-O
Amy PROPN B-O
: PUNCT B-O
amylase NOUN B-O
, PUNCT B-O
Tbili PROPN B-O
: PUNCT B-O
total NOUN B-O
bilirubin NOUN B-O
, PUNCT B-O
CRP PROPN B-O
: PUNCT B-O
c NOUN B-O
- PUNCT B-O
reactive ADJ B-O
protein NOUN B-O
, PUNCT B-O
BD PROPN B-O
: PUNCT B-O
bile NOUN B-O
duct NOUN B-O
, PUNCT B-O
CBD PROPN B-AC
: PUNCT B-O
common ADJ B-LF
bile NOUN I-LF
duct NOUN I-LF
, PUNCT B-O
PTCD PROPN B-O
: PUNCT B-O
percutaneous ADJ B-O
transhepatic ADJ B-O
cholangiography NOUN B-O
and CCONJ B-O
drainage NOUN B-O
, PUNCT B-O
PTGBD PROPN B-O
: PUNCT B-O
percutaneous ADJ B-O
transhepatic ADJ B-O
gallbladder NOUN B-O
drainage NOUN B-O
, PUNCT B-O
EST PROPN B-AC
: PUNCT B-O
endoscopic ADJ B-LF
sphincterotomy NOUN I-LF
, PUNCT B-O
EPBD PROPN B-AC
: PUNCT B-O
endoscopic ADJ B-LF
papillary ADJ I-LF
balloon NOUN I-LF
dilatation NOUN I-LF
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
analyse VERB B-O
a DET B-O
newly ADV B-O
created VERB B-O
dataset NOUN B-O
of ADP B-O
trade NOUN B-O
challenges NOUN B-O
about ADP B-O
food NOUN B-O
, PUNCT B-O
beverage NOUN B-O
, PUNCT B-O
and CCONJ B-O
tobacco NOUN B-O
regulations NOUN B-O
among ADP B-O
122 NUM B-O
World PROPN B-LF
Trade PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WTO PROPN B-AC
) PUNCT B-O
members NOUN B-O
from ADP B-O
January PROPN B-O
1 NUM B-O
, PUNCT B-O
1995 NUM B-O
to ADP B-O
December PROPN B-O
31 NUM B-O
, PUNCT B-O
2016 NUM B-O
. PUNCT B-O

Severe ADJ B-O
abdominal ADJ B-LF
aortic ADJ I-LF
calcification NOUN I-LF
( PUNCT B-O
AAC PROPN B-AC
) PUNCT B-O
is AUX B-O
associated VERB B-O
with ADP B-O
higher ADJ B-O
risk NOUN B-O
of ADP B-O
cardiovascular ADJ B-O
event NOUN B-O
and CCONJ B-O
of ADP B-O
fragility NOUN B-O
fracture NOUN B-O
. PUNCT B-O

Oxidative ADJ B-O
stress NOUN B-O
results VERB B-O
in ADP B-O
the DET B-O
generation NOUN B-O
of ADP B-O
excessive ADJ B-O
reactive ADJ B-LF
oxygen NOUN I-LF
species NOUN I-LF
( PUNCT B-O
ROS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
reactive ADJ B-LF
nitrogen NOUN I-LF
species NOUN I-LF
( PUNCT B-O
RNS PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
9–12 NUM B-O
] PUNCT B-O
, PUNCT B-O
which PRON B-O
promotes VERB B-O
the DET B-O
formation NOUN B-O
of ADP B-O
lipid NOUN B-O
peroxides NOUN B-O
and CCONJ B-O
damages VERB B-O
the DET B-O
RNA NOUN B-O
, PUNCT B-O
DNA PROPN B-O
, PUNCT B-O
and CCONJ B-O
proteins NOUN B-O
. PUNCT B-O

Further ADV B-O
, PUNCT B-O
biological ADJ B-O
samples NOUN B-O
were AUX B-O
often ADV B-O
analyzed VERB B-O
using VERB B-O
nuclear ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
spectroscopy NOUN B-O
( PUNCT B-O
NMR PROPN B-AC
) PUNCT B-O
as ADP B-O
the DET B-O
only ADJ B-O
analytical ADJ B-O
method NOUN B-O
, PUNCT B-O
data NOUN B-O
analysis NOUN B-O
was AUX B-O
mainly ADV B-O
based VERB B-O
on ADP B-O
principle ADJ B-O
component NOUN B-O
analysis NOUN B-O
( PUNCT B-O
PCA PROPN B-O
) PUNCT B-O
and CCONJ B-O
partial ADJ B-LF
least ADJ I-LF
squares NOUN I-LF
discriminant ADJ B-O
analysis NOUN B-O
( PUNCT B-O
PLS PROPN B-AC
- PUNCT B-O
DA PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
thus ADV B-O
results NOUN B-O
have AUX B-O
been AUX B-O
rather ADV B-O
descriptive ADJ B-O
[ PUNCT B-O
2 NUM B-O
, PUNCT B-O
5 NUM B-O
, PUNCT B-O
16 NUM B-O
, PUNCT B-O
18 NUM B-O
, PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

UHDRS PROPN B-AC
motor NOUN B-O
score NOUN B-O
( PUNCT B-O
A NOUN B-O
) PUNCT B-O
; PUNCT B-O
UHDRS PROPN B-AC
behavioral ADJ B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
, PUNCT B-O
IS PROPN B-AC
: PUNCT B-O
Independence PROPN B-O
Score PROPN B-O
( PUNCT B-O
C PROPN B-O
) PUNCT B-O
; PUNCT B-O
FAS PROPN B-AC
: PUNCT B-O
Functional PROPN B-LF
Assessment PROPN I-LF
Scale PROPN I-LF
( PUNCT B-O
D NOUN B-O
) PUNCT B-O
, PUNCT B-O
cognitive ADJ B-O
( PUNCT B-O
letter NOUN B-O
fluency NOUN B-O
1 NUM B-O
’ PUNCT B-O
: PUNCT B-O
at ADP B-O
1 NUM B-O
minute NOUN B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
; PUNCT B-O
letter NOUN B-O
fluency NOUN B-O
2 NUM B-O
’ PUNCT B-O
: PUNCT B-O
at ADP B-O
2 NUM B-O
minutes NOUN B-O
( PUNCT B-O
F NOUN B-O
) PUNCT B-O
; PUNCT B-O
SDMT PROPN B-AC
: PUNCT B-O
symbol NOUN B-O
digit NOUN B-O
modalities NOUN B-O
test NOUN B-O
( PUNCT B-O
G NOUN B-O
) PUNCT B-O
; PUNCT B-O
Stroop NOUN B-O
C PROPN B-O
: PUNCT B-O
Stroop NOUN B-O
color NOUN B-O
( PUNCT B-O
H NOUN B-O
) PUNCT B-O
; PUNCT B-O
Stroop NOUN B-O
W PROPN B-O
: PUNCT B-O
Stroop NOUN B-O
word NOUN B-O
( PUNCT B-O
I NOUN B-O
) PUNCT B-O
; PUNCT B-O
Stroop NOUN B-O
W PROPN B-O
/ SYM B-O
C PROPN B-O
: PUNCT B-O
Stroop NOUN B-O
interference NOUN B-O
( PUNCT B-O
J NOUN B-O
) PUNCT B-O
. PUNCT B-O

RR PROPN B-AC
, PUNCT B-O
relative ADJ B-LF
risk NOUN I-LF
. PUNCT B-O

Dpp PROPN B-AC
, PUNCT B-O
Decapentaplegic PROPN B-LF
; PUNCT B-O
GMR PROPN B-AC
, PUNCT B-O
glass NOUN B-LF
multiple ADJ I-LF
reporter NOUN I-LF
; PUNCT B-O
MF PROPN B-AC
, PUNCT B-O
morphogenetic ADJ B-LF
furrow NOUN I-LF
; PUNCT B-O
rpr PROPN B-O
, PUNCT B-O
reaper NOUN B-O
. PUNCT B-O

Since SCONJ B-O
a DET B-O
down ADJ B-O
- ADJ B-O
stream NOUN B-O
integrator NOUN B-O
of ADP B-O
metabolic ADJ B-O
alterations NOUN B-O
, PUNCT B-O
mammalian ADJ B-LF
target NOUN I-LF
of ADP I-LF
rapamycin NOUN I-LF
( PUNCT B-O
mTOR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
is AUX B-O
responsible ADJ B-O
for ADP B-O
controlling VERB B-O
the DET B-O
balance NOUN B-O
between ADP B-O
pro ADJ B-O
- ADJ B-O
inflammatory ADJ B-O
interleukin NOUN B-LF
( PUNCT B-O
IL)-12 PROPN B-AC
and CCONJ B-O
anti ADJ B-O
- ADJ B-O
inflammatory ADJ B-O
IL-10 PROPN B-AC
, PUNCT B-O
we PRON B-O
investigated VERB B-O
the DET B-O
effect NOUN B-O
of ADP B-O
upstream ADJ B-O
interference NOUN B-O
using VERB B-O
metabolic ADJ B-O
modulators NOUN B-O
on ADP B-O
the DET B-O
production NOUN B-O
of ADP B-O
pro- ADJ B-O
and CCONJ B-O
anti ADJ B-O
- ADJ B-O
inflammatory ADJ B-O
cytokines NOUN B-O
. PUNCT B-O

E NOUN B-O
: PUNCT B-O
Representative ADJ B-O
images NOUN B-O
of ADP B-O
hepatic ADJ B-O
hematoxylin NOUN B-O
and CCONJ B-O
eosin NOUN B-O
( PUNCT B-O
H&E PROPN B-O
) PUNCT B-O
, PUNCT B-O
Oil PROPN B-O
Red PROPN B-O
O NOUN B-O
and CCONJ B-O
chloroacetate NOUN B-LF
esterase NOUN I-LF
( PUNCT B-O
CAE PROPN B-AC
) PUNCT B-O
staining NOUN B-O
. PUNCT B-O

DOTS PROPN B-AC
( PUNCT B-O
directly ADV B-LF
observed VERB I-LF
treatment NOUN I-LF
, PUNCT I-LF
short ADJ I-LF
course NOUN I-LF
) PUNCT B-O
is AUX B-O
the DET B-O
internationally ADV B-O
recommended VERB B-O
control NOUN B-O
strategy NOUN B-O
for ADP B-O
TB PROPN B-AC
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Logistic ADJ B-O
regression NOUN B-O
was AUX B-O
used VERB B-O
to ADP B-O
estimate VERB B-O
the DET B-O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT B-O
OR PROPN B-AC
) PUNCT B-O
and CCONJ B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-O
interval NOUN B-O
for ADP B-O
the DET B-O
relation NOUN B-O
of ADP B-O
diabetes NOUN B-O
to ADP B-O
the DET B-O
IDE PROPN B-O
genes NOUN B-O
. PUNCT B-O

Continuous ADJ B-O
variables NOUN B-O
with ADP B-O
normal ADJ B-O
distribution NOUN B-O
are AUX B-O
reported VERB B-O
as ADP B-O
mean NOUN B-O
and CCONJ B-O
standard ADJ B-O
deviation NOUN B-O
and CCONJ B-O
compared VERB B-O
using VERB B-O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
( PUNCT B-O
ANOVA PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Variables NOUN B-O
without ADP B-O
normal ADJ B-O
distribution NOUN B-O
are AUX B-O
reported VERB B-O
as ADP B-O
median ADJ B-O
and CCONJ B-O
interquartile ADJ B-O
range NOUN B-O
( PUNCT B-O
IQR PROPN B-AC
) PUNCT B-O
and CCONJ B-O
compared VERB B-O
with ADP B-O
Kruskal PROPN B-O
- PUNCT B-O
Wallis PROPN B-O
test NOUN B-O
. PUNCT B-O

In ADP B-O
contrast NOUN B-O
, PUNCT B-O
significant ADJ B-O
progress NOUN B-O
has AUX B-O
been AUX B-O
made VERB B-O
in ADP B-O
reconstituting VERB B-O
purely ADV B-O
chemical ADJ B-O
reactions NOUN B-O
that PRON B-O
self NOUN B-O
- PUNCT B-O
organise VERB B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
the DET B-O
Belousov PROPN B-O
- PUNCT B-O
Zhabotinski PROPN B-O
reactions NOUN B-O
[ PUNCT B-O
13,14,15 NUM B-O
] PUNCT B-O
and CCONJ B-O
Turing PROPN B-O
- PUNCT B-O
type NOUN B-O
, PUNCT B-O
Meinhardt PROPN B-LF
- PUNCT I-LF
Gierer PROPN I-LF
( PUNCT B-O
M-G PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
oscillatory ADJ B-O
reactions NOUN B-O
[ PUNCT B-O
16,17,18,19,20 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
, PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
HR PROPN B-AC
, PUNCT B-O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
Ref PROPN B-O
. PUNCT B-O

, PUNCT B-O
Reference PROPN B-O
category NOUN B-O
We PRON B-O
therefore ADV B-O
aimed VERB B-O
at ADV B-O
exploring VERB B-O
the DET B-O
repertoire NOUN B-O
of ADP B-O
mRNAs NOUN B-O
bound VERB B-O
by ADP B-O
aaRSs PROPN B-AC
. PUNCT B-O

To ADP B-O
this DET B-O
end NOUN B-O
, PUNCT B-O
we PRON B-O
utilized VERB B-O
yeast NOUN B-O
strains NOUN B-O
expressing VERB B-O
endogenously ADV B-O
, PUNCT B-O
C PROPN B-O
- PUNCT B-O
terminally ADV B-O
Tandem PROPN B-LF
Affinity PROPN I-LF
Purification PROPN I-LF
( PUNCT B-O
methionyl NOUN B-LF
TAP)-tagged PROPN B-AC
- PUNCT I-LF
tRNA NOUN I-LF
synthetase NOUN I-LF
( PUNCT B-O
MetRS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
glutamyl NOUN B-LF
- PUNCT I-LF
tRNA NOUN I-LF
synthetase NOUN I-LF
( PUNCT B-O
GluRS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
valyl NOUN B-LF
- PUNCT I-LF
tRNA NOUN I-LF
synthetase NOUN I-LF
( PUNCT B-O
ValRS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
HisRS PROPN B-AC
or CCONJ B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
GFP)-tagged PROPN B-AC
HisRS PROPN B-AC
and CCONJ B-O
glutamine NOUN B-LF
- PUNCT I-LF
tRNA NOUN I-LF
synthetase NOUN I-LF
( PUNCT B-O
GlnRS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

These DET B-O
aaRSs PROPN B-AC
appeared VERB B-O
to PART B-O
be AUX B-O
associated VERB B-O
with ADP B-O
mRNA NOUN B-O
in ADP B-O
at ADV B-O
least ADV B-O
two NUM B-O
of ADP B-O
the DET B-O
yeast NOUN B-O
interactome NOUN B-O
studies NOUN B-O
( PUNCT B-O
S1 PROPN B-O
Table PROPN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
contrast NOUN B-O
to ADP B-O
other ADJ B-O
XP PROPN B-AC
patients NOUN B-O
, PUNCT B-O
those PRON B-O
with ADP B-O
the DET B-O
variant NOUN B-O
form NOUN B-O
( PUNCT B-O
XPV PROPN B-AC
) PUNCT B-O
of ADP B-O
Xeroderma PROPN B-LF
Pigmentosum PROPN I-LF
have VERB B-O
no DET B-O
defect NOUN B-O
in ADP B-O
excision NOUN B-O
repair NOUN B-O
[ PUNCT B-O
8 NUM B-O
] PUNCT B-O
, PUNCT B-O
but CCONJ B-O
are AUX B-O
deficient ADJ B-O
in ADP B-O
post ADJ B-O
- ADJ B-O
replication ADJ B-O
repair NOUN B-O
[ PUNCT B-O
23 NUM B-O
] PUNCT B-O
. PUNCT B-O

Then ADV B-O
, PUNCT B-O
we PRON B-O
selected VERB B-O
the DET B-O
compounds NOUN B-O
library NOUN B-O
which PRON B-O
included VERB B-O
those DET B-O
drug NOUN B-O
classes NOUN B-O
( PUNCT B-O
ZINC15 PROPN B-O
FDA PROPN B-O
- PUNCT B-O
approved VERB B-O
drugs NOUN B-O
) PUNCT B-O
and CCONJ B-O
carried VERB B-O
out ADP B-O
the DET B-O
virtual ADJ B-LF
screening NOUN I-LF
( PUNCT B-O
VS PROPN B-AC
) PUNCT B-O
study NOUN B-O
against ADP B-O
that DET B-O
library NOUN B-O
using VERB B-O
structures NOUN B-O
of ADP B-O
incretin NOUN B-O
receptors NOUN B-O
. PUNCT B-O

Analytical ADJ B-LF
ultracentrifugation NOUN I-LF
( PUNCT B-O
AUC PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
sedimentation NOUN B-LF
velocity NOUN I-LF
( PUNCT B-O
SV PROPN B-AC
) PUNCT B-O
mode NOUN B-O
was AUX B-O
performed VERB B-O
on ADP B-O
the DET B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
protein NOUN B-O
and CCONJ B-O
all PRON B-O
of ADP B-O
the DET B-O
mutated VERB B-O
proteins NOUN B-O
. PUNCT B-O

Virus NOUN B-O
titers NOUN B-O
were AUX B-O
determined VERB B-O
by ADP B-O
endpoint NOUN B-O
dilution NOUN B-O
assay NOUN B-O
and CCONJ B-O
calculated VERB B-O
by ADP B-O
the DET B-O
method NOUN B-O
of ADP B-O
Reed PROPN B-O
and CCONJ B-O
Muench PROPN B-O
and CCONJ B-O
expressed VERB B-O
as ADP B-O
50 NUM B-LF
% NOUN I-LF
tissue NOUN I-LF
culture NOUN I-LF
infectious ADJ I-LF
dose NOUN I-LF
( PUNCT B-O
TCID50 PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
53 NUM B-O
] PUNCT B-O
. PUNCT B-O

Examples NOUN B-O
include VERB B-O
statine NOUN B-LF
( PUNCT B-O
Sta)-containing PROPN B-AC
inhibitors NOUN B-O
and CCONJ B-O
several ADJ B-O
are AUX B-O
now ADV B-O
in ADP B-O
clinical ADJ B-O
use NOUN B-O
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

Consistently ADV B-O
, PUNCT B-O
in ADP B-O
pollen NOUN B-O
tubes NOUN B-O
tip NOUN B-O
, PUNCT B-O
ROP PROPN B-AC
/ SYM B-O
RAC PROPN B-O
proteins NOUN B-O
were AUX B-O
shown VERB B-O
to PART B-O
physically ADV B-O
associate VERB B-O
with ADP B-O
a DET B-O
phosphatidylinositol NOUN B-LF
monophosphate NOUN I-LF
kinase NOUN I-LF
( PUNCT B-O
PtdInsP-K PROPN B-AC
) PUNCT B-O
activity NOUN B-O
[ PUNCT B-O
46 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
PtdIns PROPN B-O
- PUNCT B-O
P2 PROPN B-O
, PUNCT B-O
the DET B-O
product NOUN B-O
of ADP B-O
PtdIns PROPN B-AC
, PUNCT B-O
had VERB B-O
similar ADJ B-O
distribution NOUN B-O
[ PUNCT B-O
46],[47 NUM B-O
] PUNCT B-O
. PUNCT B-O

FLPe PROPN B-O
( PUNCT B-O
Flip)-mediated NOUN B-O
recombination NOUN B-O
resulted VERB B-O
in ADP B-O
a DET B-O
continuous ADJ B-O
reading NOUN B-O
frame NOUN B-O
from ADP B-O
the DET B-O
authentic ADJ B-O
Mll2 NOUN B-O
initiating VERB B-O
codon NOUN B-O
, PUNCT B-O
through ADP B-O
eYFP NOUN B-O
and CCONJ B-O
the DET B-O
residual ADJ B-O
FRT NOUN B-O
to PART B-O
the DET B-O
second ADJ B-O
amino NOUN B-O
acid NOUN B-O
of ADP B-O
Mll2 NOUN B-O
. PUNCT B-O

( PUNCT B-O
B NOUN B-O
) PUNCT B-O
Mice NOUN B-O
carrying VERB B-O
a DET B-O
single ADJ B-O
copy NOUN B-O
of ADP B-O
Mll2 NOUN B-O
tm2 NOUN B-O
( PUNCT B-O
Mll2 NOUN B-O
tm2/+ NOUN B-O
) PUNCT B-O
were AUX B-O
intercrossed VERB B-O
to PART B-O
obtain VERB B-O
control NOUN B-O
( PUNCT B-O
Mll2 NOUN B-O
+ X B-O
/+and CCONJ B-O
Mll2 NOUN B-O
tm2/+ NOUN B-O
) PUNCT B-O
and CCONJ B-O
experimental ADJ B-O
Mll2 NOUN B-O
tm2 NOUN B-O
/ SYM B-O
tm2 NOUN B-O
mice NOUN B-O
. PUNCT B-O

( PUNCT B-O
C X B-O
) PUNCT B-O
Southern PROPN B-O
blot NOUN B-O
analysis NOUN B-O
of ADP B-O
tail NOUN B-O
genomic ADJ B-O
DNA NOUN B-O
: PUNCT B-O
a DET B-O
3.8 NUM B-O
kb NOUN B-O
band NOUN B-O
denotes VERB B-O
the DET B-O
Mll2 NOUN B-O
tm2 NOUN B-O
/ SYM B-O
tm2 NOUN B-O
allele NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
a DET B-O
3.0 NUM B-O
kb NOUN B-O
band NOUN B-O
denotes VERB B-O
the DET B-O
wild ADJ B-LF
type NOUN I-LF
( PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
allele NOUN B-O
. PUNCT B-O

Fewer ADJ B-O
falls NOUN B-O
( PUNCT B-O
incidence NOUN B-LF
rate NOUN I-LF
ratio NOUN I-LF
[ PUNCT B-O
IRR PROPN B-AC
] PUNCT B-O
: PUNCT B-O
0.65 NUM B-O
, PUNCT B-O
0.43–0.99 NUM B-O
; PUNCT B-O
P NOUN B-O
= SYM B-O
0.042 NUM B-O
) PUNCT B-O
were AUX B-O
observed VERB B-O
in ADP B-O
the DET B-O
RESPOND NOUN B-O
group NOUN B-O
compared VERB B-O
with ADP B-O
the DET B-O
control NOUN B-O
( PUNCT B-O
Table PROPN B-O
3 NUM B-O
) PUNCT B-O
. PUNCT B-O

Cancer NOUN B-O
development NOUN B-O
and CCONJ B-O
tumor NOUN B-O
growth NOUN B-O
are AUX B-O
driven VERB B-O
by ADP B-O
specific ADJ B-O
types NOUN B-O
of ADP B-O
cells NOUN B-O
— PUNCT B-O
stem NOUN B-LF
cell NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
cancer NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
SCLCCs)—which PROPN B-AC
are AUX B-O
also ADV B-O
responsible ADJ B-O
for ADP B-O
metastatic ADJ B-O
spread NOUN B-O
and CCONJ B-O
drug NOUN B-O
resistance NOUN B-O
. PUNCT B-O

Under ADP B-O
some DET B-O
conditions NOUN B-O
, PUNCT B-O
the DET B-O
C262 PROPN B-O
- PUNCT B-O
S PROPN B-AC
P NOUN B-O
ribozyme NOUN B-LF
E·S·G PROPN B-AC
ternary ADJ B-O
complex NOUN B-O
must AUX B-O
undergo VERB B-O
a DET B-O
rate NOUN B-O
- PUNCT B-O
limiting VERB B-O
conformational ADJ B-O
change NOUN B-O
en ADP B-O
route NOUN B-O
to ADP B-O
the DET B-O
chemical ADJ B-O
transition NOUN B-O
state NOUN B-O
. PUNCT B-O

To PART B-O
address VERB B-O
these DET B-O
concerns NOUN B-O
, PUNCT B-O
we PRON B-O
propose VERB B-O
a DET B-O
new ADJ B-O
generic ADJ B-O
approach NOUN B-O
for ADP B-O
estimating VERB B-O
the DET B-O
distribution NOUN B-O
of ADP B-O
incident NOUN B-O
infections NOUN B-O
acquired VERB B-O
according VERB B-O
to PART B-O
identifiable ADJ B-O
determinants NOUN B-O
of ADP B-O
risk NOUN B-O
in ADP B-O
the DET B-O
generalised VERB B-O
epidemics NOUN B-O
of ADP B-O
SSA PROPN B-AC
. PUNCT B-O

The DET B-O
objectives NOUN B-O
of ADP B-O
this DET B-O
study NOUN B-O
were AUX B-O
to PART B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
describe VERB B-O
the DET B-O
Incidence PROPN B-LF
Patterns PROPN I-LF
Model PROPN I-LF
( PUNCT B-O
IPM PROPN B-AC
) PUNCT B-O
for ADP B-O
SSA PROPN B-AC
, PUNCT B-O
( PUNCT B-O
2 X B-O
) PUNCT B-O
validate VERB B-O
and CCONJ B-O
train VERB B-O
the DET B-O
IPM PROPN B-AC
using VERB B-O
data NOUN B-O
from ADP B-O
cohort NOUN B-O
studies NOUN B-O
in ADP B-O
four NUM B-O
countries NOUN B-O
, PUNCT B-O
( PUNCT B-O
3 X B-O
) PUNCT B-O
apply VERB B-O
the DET B-O
IPM PROPN B-AC
to PART B-O
six NUM B-O
different ADJ B-O
countries NOUN B-O
to PART B-O
show VERB B-O
the DET B-O
predicted VERB B-O
distributions NOUN B-O
of ADP B-O
newly ADV B-O
acquired VERB B-O
HIV PROPN B-O
infections NOUN B-O
in ADP B-O
different ADJ B-O
population NOUN B-O
groups NOUN B-O
, PUNCT B-O
and CCONJ B-O
( PUNCT B-O
4 X B-O
) PUNCT B-O
use VERB B-O
the DET B-O
IPM PROPN B-AC
outputs NOUN B-O
to PART B-O
infer VERB B-O
the DET B-O
distributions NOUN B-O
of ADP B-O
the DET B-O
groups NOUN B-O
transmitting VERB B-O
HIV PROPN B-O
. PUNCT B-O

The DET B-O
accumulation NOUN B-O
of ADP B-O
TAG PROPN B-AC
- PUNCT B-O
containing VERB B-O
lipid NOUN B-O
droplets NOUN B-O
in ADP B-O
multiple ADJ B-O
tissues NOUN B-O
characteristic ADJ B-O
of ADP B-O
CDS PROPN B-O
has AUX B-O
been AUX B-O
linked VERB B-O
to ADP B-O
impaired ADJ B-O
lipolysis NOUN B-O
caused VERB B-O
by ADP B-O
mutations NOUN B-O
in ADP B-O
comparative ADJ B-LF
gene NOUN I-LF
identification NOUN I-LF
58 NUM I-LF
( PUNCT B-O
CGI-58 PROPN B-AC
; PUNCT B-O
also ADV B-O
called VERB B-O
ABHD5 NOUN B-O
) PUNCT B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

Hepatorenal PROPN B-LF
syndrome NOUN I-LF
( PUNCT B-O
HRS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
most ADV B-O
severe ADJ B-O
form NOUN B-O
of ADP B-O
AKI PROPN B-AC
in ADP B-O
cirrhosis NOUN B-O
, PUNCT B-O
develops VERB B-O
in ADP B-O
more ADJ B-O
than ADP B-O
50 NUM B-O
% NOUN B-O
of ADP B-O
patients NOUN B-O
with ADP B-O
cirrhosis NOUN B-O
who PRON B-O
die VERB B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

PCA PROPN B-AC
, PUNCT B-O
principal ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
. PUNCT B-O

BHIS PROPN B-AC
, PUNCT B-O
brain NOUN B-LF
heart NOUN I-LF
infusion NOUN I-LF
plus CCONJ I-LF
yeast NOUN I-LF
; PUNCT B-O
c PROPN B-AC
, PUNCT B-O
cyclic ADJ B-LF
diguanosine NOUN I-LF
monophosphate NOUN I-LF
; PUNCT B-O
cmr NOUN B-O
, PUNCT B-O
colony NOUN B-O
morphology NOUN B-O
regulators NOUN B-O
; PUNCT B-O
-di-GMPDccA PROPN B-AC
, PUNCT B-O
diguanylate NOUN B-LF
cyclase NOUN I-LF
A NOUN I-LF
; PUNCT B-O
erm PROPN B-AC
, PUNCT B-O
erythromycin NOUN B-LF
resistance NOUN I-LF
cassette NOUN I-LF
; PUNCT B-O
mut NOUN B-O
, PUNCT B-O
mutant NOUN B-O
; PUNCT B-O
R NOUN B-O
, PUNCT B-O
rough ADJ B-O
; PUNCT B-O
S NOUN B-O
, PUNCT B-O
smooth NOUN B-O
; PUNCT B-O
qPCR PROPN B-AC
, PUNCT B-O
quantitative ADJ B-LF
PCR NOUN I-LF
; PUNCT B-O
qRT PROPN B-AC
, PUNCT B-O
quantitative ADJ B-LF
real ADJ I-LF
- PUNCT I-LF
time NOUN I-LF
PCR NOUN I-LF
; PUNCT B-O
sigD NOUN B-O
, PUNCT B-O
sigma NOUN B-O
factor NOUN B-O
D PROPN B-O
gene NOUN B-O
; PUNCT B-O
-PCRTFP PROPN B-AC
, PUNCT B-O
type NOUN B-LF
IV NUM I-LF
pilus NOUN I-LF
. PUNCT B-O

Interferon PROPN B-LF
( PUNCT B-O
IFN PROPN B-AC
) PUNCT B-O
therapy NOUN B-O
has AUX B-O
been AUX B-O
proved VERB B-O
to PART B-O
achieve VERB B-O
sustained ADJ B-LF
virologic ADJ I-LF
response NOUN I-LF
( PUNCT B-O
SVR PROPN B-AC
) PUNCT B-O
in ADP B-O
patients NOUN B-O
with ADP B-O
chronic ADJ B-O
HCV PROPN B-AC
infection NOUN B-O
and CCONJ B-O
can AUX B-O
prevent VERB B-O
progression NOUN B-O
of ADP B-O
liver NOUN B-O
fibrosis NOUN B-O
. PUNCT B-O

Thus ADV B-O
, PUNCT B-O
we PRON B-O
expressed VERB B-O
carnitine NOUN B-O
palmitoyltransferase NOUN B-O
1AM PROPN B-O
( PUNCT B-O
CPT1AM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
permanently ADV B-LF
active ADJ I-LF
mutant ADJ I-LF
form NOUN I-LF
of ADP I-LF
CPT1A PROPN I-LF
CPT1A PROPN B-AC
( PUNCT B-O
the DET B-O
rate NOUN B-O
- PUNCT B-O
limiting VERB B-O
enzyme NOUN B-O
in ADP B-O
FAO PROPN B-AC
) PUNCT B-O
, PUNCT B-O
in ADP B-O
a DET B-O
rat NOUN B-O
brown ADJ B-O
adipocyte NOUN B-O
( PUNCT B-O
rBA PROPN B-AC
) PUNCT B-O
cell NOUN B-O
line NOUN B-O
through ADP B-O
adenoviral ADJ B-O
infection NOUN B-O
. PUNCT B-O

In ADP B-O
neurons NOUN B-O
, PUNCT B-O
the DET B-O
gp120 PROPN B-O
interaction NOUN B-O
with ADP B-O
CXCR4 PROPN B-AC
enhances VERB B-O
Ca2 NOUN B-O
+ NOUN B-O
-regulating VERB B-O
systems NOUN B-O
through ADP B-O
NMDA PROPN B-O
receptors NOUN B-O
( PUNCT B-O
NMDARs PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
synaptic ADJ B-O
membrane NOUN B-O
and CCONJ B-O
inositol NOUN B-O
trisphosphate NOUN B-O
receptors NOUN B-O
( PUNCT B-O
IP3Rs PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT B-O
ER PROPN B-AC
) PUNCT B-O
, PUNCT B-O
resulting VERB B-O
in ADP B-O
apoptosis NOUN B-O
[ PUNCT B-O
28–34 NUM B-O
] PUNCT B-O
. PUNCT B-O

Brain NOUN B-LF
– PUNCT I-LF
machine NOUN I-LF
interfaces NOUN I-LF
( PUNCT B-O
BMIs PROPN B-AC
) PUNCT B-O
have VERB B-O
the DET B-O
potential NOUN B-O
to PART B-O
revolutionize VERB B-O
the DET B-O
care NOUN B-O
of ADP B-O
neurologically ADV B-O
impaired ADJ B-O
patients NOUN B-O
. PUNCT B-O

Antimicrobial ADJ B-LF
peptides NOUN I-LF
( PUNCT B-O
AMPs PROPN B-AC
) PUNCT B-O
play VERB B-O
a DET B-O
key ADJ B-O
role NOUN B-O
in ADP B-O
innate ADJ B-O
immune ADJ B-O
response NOUN B-O
against ADP B-O
bacteria NOUN B-O
, PUNCT B-O
viruses NOUN B-O
, PUNCT B-O
fungi NOUN B-O
, PUNCT B-O
and CCONJ B-O
parasites NOUN B-O
[ PUNCT B-O
20,21 NUM B-O
] PUNCT B-O
. PUNCT B-O

FFR PROPN B-AC
, PUNCT B-O
fractional ADJ B-LF
flow NOUN I-LF
reserve NOUN I-LF
. PUNCT B-O

Co ADJ B-O
- PUNCT B-O
primary ADJ B-O
short- ADJ B-O
and CCONJ B-O
long ADJ B-O
- PUNCT B-O
term NOUN B-O
outcomes NOUN B-O
were AUX B-O
1 NUM B-O
- PUNCT B-O
year NOUN B-O
total ADJ B-LF
kidney NOUN I-LF
volume NOUN I-LF
( PUNCT B-O
TKV PROPN B-AC
) PUNCT B-O
( PUNCT B-O
computed ADJ B-O
tomography NOUN B-O
scan NOUN B-O
) PUNCT B-O
growth NOUN B-O
and CCONJ B-O
3 NUM B-O
- PUNCT B-O
year NOUN B-O
GFR PROPN B-AC
( PUNCT B-O
iohexol NOUN B-O
plasma NOUN B-O
clearance NOUN B-O
) PUNCT B-O
decline NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
HEI PROPN B-AC
, PUNCT B-O
Healthy PROPN B-LF
Eating PROPN I-LF
Index PROPN I-LF
; PUNCT B-O
Q NOUN B-O
, PUNCT B-O
quartile NOUN B-O
. PUNCT B-O

Indeed ADV B-O
, PUNCT B-O
discrimination NOUN B-O
of ADP B-O
the DET B-O
mother NOUN B-O
and CCONJ B-O
daughter NOUN B-O
using VERB B-O
CEP164 PROPN B-O
immunostaining NOUN B-O
showed VERB B-O
that SCONJ B-O
roots NOUN B-O
are AUX B-O
nucleated VERB B-O
symmetrically ADV B-O
on ADP B-O
both CCONJ B-O
mother NOUN B-O
and CCONJ B-O
daughter NOUN B-O
( PUNCT B-O
Fig NOUN B-O
4B NUM B-O
) PUNCT B-O
. PUNCT B-O

A DET B-O
similar ADJ B-O
comparison NOUN B-O
of ADP B-O
PCM PROPN B-AC
structure NOUN B-O
with ADP B-O
the DET B-O
PCM PROPN B-AC
resident NOUN B-O
Pericentrin PROPN B-LF
( PUNCT B-O
PCNT PROPN B-AC
) PUNCT B-O
showed VERB B-O
similarly ADV B-O
that SCONJ B-O
both CCONJ B-O
mother NOUN B-O
and CCONJ B-O
daughter NOUN B-O
centrioles NOUN B-O
individually ADV B-O
nucleate VERB B-O
PCM PROPN B-AC
when SCONJ B-O
split VERB B-O
( PUNCT B-O
Fig NOUN B-O
4C NUM B-O
) PUNCT B-O
, PUNCT B-O
something PRON B-O
also ADV B-O
evident ADJ B-O
in ADP B-O
the DET B-O
live ADJ B-O
- PUNCT B-O
cell NOUN B-O
imaging NOUN B-O
of ADP B-O
NEDD1 PROPN B-AC
- PUNCT B-O
mRuby3 PROPN B-O
( PUNCT B-O
Fig NOUN B-O
3H–3 NUM B-O
K NUM B-O
) PUNCT B-O
and CCONJ B-O
previous ADJ B-O
work NOUN B-O
[ X B-O
24,32,34 NUM B-O
] PUNCT B-O
. PUNCT B-O

Water NOUN B-O
deficit NOUN B-O
was AUX B-O
initiated VERB B-O
when SCONJ B-O
seedlings NOUN B-O
were AUX B-O
almost ADV B-O
20 NUM B-O
day NOUN B-O
- PUNCT B-O
old ADJ B-O
, PUNCT B-O
attaining VERB B-O
2–3 NUM B-O
true ADJ B-O
leaves NOUN B-O
and CCONJ B-O
it PRON B-O
was AUX B-O
applied VERB B-O
by ADP B-O
maintaining VERB B-O
the DET B-O
soil NOUN B-O
moisture NOUN B-O
at ADP B-O
40 NUM B-O
% NOUN B-O
of ADP B-O
substrate NOUN B-O
field NOUN B-LF
capacity NOUN I-LF
( PUNCT B-O
FC PROPN B-AC
) PUNCT B-O
for ADP B-O
the DET B-O
stressed VERB B-O
plants NOUN B-O
, PUNCT B-O
and CCONJ B-O
80 NUM B-O
% NOUN B-O
FC PROPN B-AC
for ADP B-O
the DET B-O
well ADV B-O
- PUNCT B-O
watered VERB B-O
plants NOUN B-O
. PUNCT B-O

It PRON B-O
would AUX B-O
be AUX B-O
worth ADJ B-O
noting VERB B-O
that PRON B-O
the DET B-O
clustered VERB B-O
lysine NOUN B-O
residues NOUN B-O
that PRON B-O
we PRON B-O
found VERB B-O
as ADP B-O
TMP195 NOUN B-O
- ADJ B-O
sensitive ADJ B-O
acetylation NOUN B-O
sites NOUN B-O
were AUX B-O
located VERB B-O
in ADP B-O
the DET B-O
N NOUN B-O
- ADJ B-O
terminal ADJ B-O
intrinsically ADV B-LF
disordered VERB I-LF
region NOUN I-LF
( PUNCT B-O
IDR PROPN B-AC
) PUNCT B-O
of ADP B-O
NCL PROPN B-AC
( PUNCT B-O
S7C PROPN B-O
Fig PROPN B-O
) PUNCT B-O
[ PUNCT B-O
87 NUM B-O
] PUNCT B-O
. PUNCT B-O

They PRON B-O
recognize VERB B-O
bacterial ADJ B-O
surface NOUN B-O
molecules NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
lipopolysaccharides NOUN B-O
( PUNCT B-O
LPS PROPN B-AC
) PUNCT B-O
from ADP B-O
the DET B-O
outer ADJ B-O
wall NOUN B-O
of ADP B-O
Gram NOUN B-O
- PUNCT B-O
negative ADJ B-O
bacteria NOUN B-O
and CCONJ B-O
flagellin NOUN B-LF
( PUNCT B-O
FLG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
a DET B-O
structural ADJ B-O
protein NOUN B-O
of ADP B-O
flagellum NOUN B-O
, PUNCT B-O
a DET B-O
bacterial ADJ B-O
locomotive NOUN B-O
organelle NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
OR PROPN B-AC
: PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
: PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
. PUNCT B-O

MOI PROPN B-AC
represents VERB B-O
the DET B-O
multiplicity NOUN B-LF
of ADP I-LF
infection NOUN I-LF
. PUNCT B-O

Both DET B-O
domains NOUN B-O
share VERB B-O
approximately ADV B-O
9 NUM B-O
% NOUN B-O
sequence NOUN B-O
identity NOUN B-O
and CCONJ B-O
can AUX B-O
be AUX B-O
superimposed VERB B-O
with ADP B-O
a DET B-O
root NOUN B-LF
mean ADJ I-LF
square ADJ I-LF
( PUNCT B-O
rms PROPN B-AC
) PUNCT B-O
deviation NOUN B-O
of ADP B-O
2.4 NUM B-O
Å NOUN B-O
using VERB B-O
101 NUM B-O
Cα NOUN B-O
- NOUN B-O
atoms NOUN B-O
out ADP B-O
of ADP B-O
153 NUM B-O
from ADP B-O
domain NOUN B-O
1 NUM B-O
, PUNCT B-O
and CCONJ B-O
201 NUM B-O
from ADP B-O
domain NOUN B-O
4 NUM B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O

The DET B-O
study NOUN B-O
was AUX B-O
carried VERB B-O
out ADP B-O
in ADP B-O
collaboration NOUN B-O
with ADP B-O
the DET B-O
Swiss PROPN B-LF
Childhood PROPN I-LF
Cancer PROPN I-LF
Registry PROPN I-LF
( PUNCT B-O
SCCR PROPN B-AC
, PUNCT B-O
www.childhoodcancerregistry.ch X B-O
) PUNCT B-O
, PUNCT B-O
which PRON B-O
, PUNCT B-O
since SCONJ B-O
1976 NUM B-O
, PUNCT B-O
has AUX B-O
included VERB B-O
all DET B-O
children NOUN B-O
and CCONJ B-O
adolescents NOUN B-O
in ADP B-O
Switzerland PROPN B-O
diagnosed VERB B-O
with ADP B-O
leukemia NOUN B-O
, PUNCT B-O
lymphoma NOUN B-O
, PUNCT B-O
central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
( PUNCT B-O
CNS PROPN B-AC
) PUNCT B-O
tumors NOUN B-O
, PUNCT B-O
malignant ADJ B-O
solid ADJ B-O
tumors NOUN B-O
and CCONJ B-O
Langerhans PROPN B-LF
cell NOUN I-LF
histiocytosis NOUN I-LF
( PUNCT B-O
LCH PROPN B-AC
) PUNCT B-O
before SCONJ B-O
they PRON B-O
were AUX B-O
21 NUM B-O
[ PUNCT B-O
17 NUM B-O
] PUNCT B-O
. PUNCT B-O

Yunnan PROPN B-O
province NOUN B-O
itself PRON B-O
has VERB B-O
a DET B-O
large ADJ B-O
population NOUN B-O
of ADP B-O
people NOUN B-LF
who PRON I-LF
inject VERB I-LF
drugs NOUN I-LF
( PUNCT B-O
PWID PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
15 NUM B-O
, PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

possibly ADV B-O
due ADP B-O
to ADP B-O
Yunnan PROPN B-O
’s PART B-O
position NOUN B-O
along ADP B-O
key ADJ B-O
heroin NOUN B-O
trafficking NOUN B-O
routes NOUN B-O
into ADP B-O
China PROPN B-O
[ PUNCT B-O
17 NUM B-O
, PUNCT B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

A3A PROPN B-AC
, PUNCT B-O
APOBEC3A. PROPN B-LF
Serial ADJ B-O
10 NUM B-O
- PUNCT B-O
fold ADJ B-O
dilution NOUN B-O
from ADP B-O
indicated VERB B-O
strains NOUN B-O
spotted VERB B-O
onto ADP B-O
media NOUN B-O
containing VERB B-O
indicated VERB B-O
hydroxyurea NOUN B-LF
( PUNCT B-O
HU PROPN B-AC
, PUNCT B-O
top ADJ B-O
panel NOUN B-O
) PUNCT B-O
or CCONJ B-O
camptothecin NOUN B-LF
( PUNCT B-O
CPT PROPN B-AC
, PUNCT B-O
bottom ADJ B-O
panel NOUN B-O
) PUNCT B-O
concentration NOUN B-O
. PUNCT B-O

The DET B-O
complete ADJ B-O
results NOUN B-O
for ADP B-O
two NUM B-O
distinct ADJ B-O
diplococci NOUN B-O
( PUNCT B-O
no NOUN B-O
. PUNCT B-O

109 NUM B-O
and CCONJ B-O
no NOUN B-O
. PUNCT B-O

110 NUM B-O
) PUNCT B-O
are AUX B-O
presented VERB B-O
in ADP B-O
Figure PROPN B-O
S3 NUM B-O
. PUNCT B-O

The DET B-O
position NOUN B-O
coordinates NOUN B-O
of ADP B-O
individual ADJ B-O
diplococci NOUN B-O
mounted VERB B-O
on ADP B-O
formvar NOUN B-O
- NOUN B-O
coated VERB B-O
gold NOUN B-O
TEM PROPN B-AC
grids NOUN B-O
were AUX B-O
determined VERB B-O
by ADP B-O
light NOUN B-LF
microscopy NOUN I-LF
( PUNCT B-O
LM PROPN B-AC
) PUNCT B-O
. PUNCT B-O

TEM PROPN B-AC
grids NOUN B-O
were AUX B-O
subsequently ADV B-O
placed VERB B-O
in ADP B-O
the DET B-O
focal ADJ B-O
plane NOUN B-O
of ADP B-O
the DET B-O
X NOUN B-O
- NOUN B-O
ray NOUN B-O
optic NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
grid NOUN B-O
markers NOUN B-O
were AUX B-O
used VERB B-O
to PART B-O
locate VERB B-O
the DET B-O
targeted VERB B-O
cells NOUN B-O
. PUNCT B-O

Because SCONJ B-O
PMNs PROPN B-AC
adhere VERB B-O
to ADP B-O
plates NOUN B-O
after ADP B-O
activation NOUN B-O
, PUNCT B-O
the DET B-O
use NOUN B-O
of ADP B-O
counting NOUN B-O
by ADP B-O
flow NOUN B-O
cytometry NOUN B-O
was AUX B-O
ineffective ADJ B-O
for ADP B-O
determining VERB B-O
viability NOUN B-O
, PUNCT B-O
and CCONJ B-O
instead ADV B-O
viability NOUN B-O
was AUX B-O
assessed VERB B-O
using VERB B-O
cytosolic ADJ B-O
mammalian ADJ B-O
- PUNCT B-O
specific ADJ B-O
lactate NOUN B-LF
dehydrogenase NOUN I-LF
( PUNCT B-O
LDH PROPN B-AC
) PUNCT B-O
detection NOUN B-O
in ADP B-O
supernatants NOUN B-O
using VERB B-O
the DET B-O
CytoTox PROPN B-O
- PUNCT B-O
One NUM B-O
homogeneous ADJ B-O
membrane NOUN B-O
integrity NOUN B-O
assay NOUN B-O
( PUNCT B-O
Promega PROPN B-O
, PUNCT B-O
Madison PROPN B-O
, PUNCT B-O
WI PROPN B-O
) PUNCT B-O
as SCONJ B-O
described VERB B-O
[ PUNCT B-O
27 NUM B-O
] PUNCT B-O
. PUNCT B-O

Data NOUN B-O
on ADP B-O
sow NOUN B-O
, PUNCT B-O
piglet NOUN B-O
, PUNCT B-O
weaner NOUN B-O
and CCONJ B-O
fattening NOUN B-O
pig NOUN B-O
holdings NOUN B-O
were AUX B-O
described VERB B-O
separately ADV B-O
, PUNCT B-O
using VERB B-O
the DET B-O
semi ADJ B-O
- ADJ B-O
annual ADJ B-O
treatment NOUN B-LF
frequency NOUN I-LF
( PUNCT B-O
TF PROPN B-AC
) PUNCT B-O
to PART B-O
measure VERB B-O
antibiotic ADJ B-O
consumption NOUN B-O
. PUNCT B-O

MHC PROPN B-AC
, PUNCT B-O
major ADJ B-LF
histocompatibility NOUN I-LF
complex NOUN I-LF
. PUNCT B-O

Many ADJ B-O
activation NOUN B-O
events NOUN B-O
downstream ADV B-O
of ADP B-O
the DET B-O
T NOUN B-LF
- PUNCT I-LF
cell NOUN I-LF
antigen NOUN I-LF
receptor NOUN I-LF
( PUNCT B-O
TCR PROPN B-AC
) PUNCT B-O
are AUX B-O
up ADV B-O
- PUNCT B-O
regulated VERB B-O
by ADP B-O
the DET B-O
nuclear ADJ B-LF
factor NOUN I-LF
of ADP I-LF
activated VERB I-LF
T NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
NFAT PROPN B-AC
) PUNCT B-O
transcription NOUN B-O
factor NOUN B-O
family NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
copy NOUN B-LF
number NOUN I-LF
variation NOUN I-LF
( PUNCT B-O
CNV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
well ADV B-O
- ADJ B-O
established VERB B-O
source NOUN B-O
of ADP B-O
inter ADJ B-O
- ADJ B-O
individual ADJ B-O
genetic ADJ B-O
variation NOUN B-O
[ X B-O
5 NUM B-O
, PUNCT B-O
13 NUM B-O
, PUNCT B-O
14 NUM B-O
] PUNCT B-O
has AUX B-O
also ADV B-O
been AUX B-O
reported VERB B-O
to PART B-O
target VERB B-O
several ADJ B-O
FcγR PROPN B-AC
genes NOUN B-O
and CCONJ B-O
can AUX B-O
alter VERB B-O
surface NOUN B-O
FcγR PROPN B-AC
protein NOUN B-O
expression NOUN B-O
and CCONJ B-O
cellular ADJ B-O
function NOUN B-O
[ X B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

Humoral ADJ B-O
allo ADJ B-O
- PUNCT B-O
immune ADJ B-O
responses NOUN B-O
mediated VERB B-O
by ADP B-O
donor NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
antibodies NOUN I-LF
( PUNCT B-O
DSA PROPN B-AC
) PUNCT B-O
is AUX B-O
now ADV B-O
well ADV B-O
recognized VERB B-O
as ADP B-O
a DET B-O
detrimental ADJ B-O
determinant NOUN B-O
of ADP B-O
graft NOUN B-O
outcome NOUN B-O
after ADP B-O
solid ADJ B-O
organ NOUN B-O
transplantation NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

USP6 PROPN B-O
transgenic VERB B-O
mice NOUN B-O
exhibited VERB B-O
enhanced ADJ B-O
learning NOUN B-O
and CCONJ B-O
memory NOUN B-O
behavior NOUN B-O
in ADP B-O
Morris PROPN B-LF
water PROPN I-LF
maze PROPN I-LF
( PUNCT B-O
MWM PROPN B-AC
) PUNCT B-O
and CCONJ B-O
novel ADJ B-LF
object NOUN I-LF
recognition NOUN I-LF
( PUNCT B-O
NOR PROPN B-AC
) PUNCT B-O
tests NOUN B-O
. PUNCT B-O

Tether NOUN B-O
proteins NOUN B-O
attach VERB B-O
the DET B-O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT B-O
ER PROPN B-AC
) PUNCT B-O
to PART B-O
other ADJ B-O
cellular ADJ B-O
membranes NOUN B-O
, PUNCT B-O
thereby ADV B-O
creating VERB B-O
contact NOUN B-O
sites NOUN B-O
that PRON B-O
are AUX B-O
proposed VERB B-O
to PART B-O
form VERB B-O
platforms NOUN B-O
for ADP B-O
regulating VERB B-O
lipid NOUN B-O
homeostasis NOUN B-O
and CCONJ B-O
facilitating VERB B-O
non ADJ B-O
- ADJ B-O
vesicular ADJ B-O
lipid NOUN B-O
exchange NOUN B-O
. PUNCT B-O

Oral ADJ B-LF
cholera NOUN I-LF
vaccine NOUN I-LF
( PUNCT B-O
OCV PROPN B-AC
) PUNCT B-O
plays VERB B-O
a DET B-O
key ADJ B-O
role NOUN B-O
in ADP B-O
reducing VERB B-O
the DET B-O
near ADJ B-O
- PUNCT B-O
term NOUN B-O
risk NOUN B-O
of ADP B-O
cholera NOUN B-O
, PUNCT B-O
although SCONJ B-O
global ADJ B-O
supplies NOUN B-O
are AUX B-O
limited ADJ B-O
. PUNCT B-O

Emitted VERB B-O
photons NOUN B-O
were AUX B-O
detected VERB B-O
with ADP B-O
a DET B-O
single ADJ B-LF
- PUNCT I-LF
photon NOUN I-LF
avalanche NOUN I-LF
diode NOUN I-LF
( PUNCT B-O
SPAD PROPN B-AC
) PUNCT B-O
detector NOUN B-O
( PUNCT B-O
SPCM PROPN B-O
CD3516H PROPN B-O
; PUNCT B-O
Excelitas PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
a DET B-O
time NOUN B-O
- PUNCT B-O
correlated VERB B-O
single ADJ B-O
- PUNCT B-O
photon NOUN B-O
counting VERB B-O
unit NOUN B-O
( PUNCT B-O
HydraHarp PROPN B-O
400 NUM B-O
; PUNCT B-O
PicoQuant PROPN B-O
) PUNCT B-O
was AUX B-O
used VERB B-O
to PART B-O
generate VERB B-O
picosecond NOUN B-O
histograms NOUN B-O
( PUNCT B-O
16 NUM B-O
ps NOUN B-O
resolution NOUN B-O
) PUNCT B-O
from ADP B-O
the DET B-O
photon NOUN B-O
arrival NOUN B-O
times NOUN B-O
. PUNCT B-O

TBB PROPN B-AC
is AUX B-O
a DET B-O
selective ADJ B-O
, PUNCT B-O
cell NOUN B-O
- PUNCT B-O
permeable ADJ B-O
, PUNCT B-O
ATP PROPN B-O
/ SYM B-O
GTP NOUN B-O
- PUNCT B-O
competitive ADJ B-O
inhibitor NOUN B-O
of ADP B-O
casein NOUN B-LF
kinase NOUN I-LF
II NUM I-LF
( PUNCT B-O
CKII PROPN B-AC
) PUNCT B-O
( PUNCT B-O
IC50 NUM B-O
= SYM B-O
900 NUM B-O
nM NOUN B-O
for ADP B-O
rat ADJ B-O
liver NOUN B-O
) PUNCT B-O
[ PUNCT B-O
124 NUM B-O
] PUNCT B-O
. PUNCT B-O

Berberine PROPN B-LF
( PUNCT B-O
BBR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
an DET B-O
isoquinoline NOUN B-O
alkaloid NOUN B-O
isolated VERB B-O
from ADP B-O
many ADJ B-O
medicinal ADJ B-O
herbs NOUN B-O
, PUNCT B-O
is AUX B-O
one NUM B-O
of ADP B-O
the DET B-O
widely ADV B-O
used VERB B-O
traditional ADJ B-O
Chinese ADJ B-O
medicines NOUN B-O
and CCONJ B-O
has AUX B-O
been AUX B-O
used VERB B-O
to PART B-O
treat VERB B-O
various ADJ B-O
infectious ADJ B-O
disorders NOUN B-O
for ADP B-O
more ADJ B-O
than ADP B-O
3,000 NUM B-O
years NOUN B-O
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

Lower ADJ B-LF
limit NOUN I-LF
of ADP I-LF
quantitation NOUN I-LF
( PUNCT B-O
LLoQ PROPN B-AC
) PUNCT B-O
and CCONJ B-O
limit NOUN B-LF
of ADP I-LF
detection NOUN I-LF
( PUNCT B-O
LoD PROPN B-AC
) PUNCT B-O
were AUX B-O
determined VERB B-O
by ADP B-O
measurement NOUN B-O
precision NOUN B-O
using VERB B-O
serial ADJ B-O
dilutions NOUN B-O
of ADP B-O
LAM PROPN B-AC
extracts NOUN B-O
obtained VERB B-O
from ADP B-O
M. PROPN B-O
bovis PROPN B-O
Bacillus PROPN B-O
Calmette PROPN B-O
- PUNCT B-O
Guérin PROPN B-O
Tokyo PROPN B-O
( PUNCT B-O
BCG PROPN B-AC
) PUNCT B-O
culture NOUN B-O
. PUNCT B-O

Before ADP B-O
dissociation NOUN B-O
of ADP B-O
C120 PROPN B-O
from ADP B-O
Z775mAG PROPN B-O
, PUNCT B-O
the DET B-O
head NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
head NOUN I-LF
distance NOUN I-LF
( PUNCT B-O
i.e. X B-O
, PUNCT B-O
the DET B-O
distance NOUN B-O
between ADP B-O
the DET B-O
centers NOUN B-O
of ADP B-O
mass NOUN B-O
of ADP B-O
ZEN-4 NOUN B-O
motor NOUN B-O
domains NOUN B-O
[ X B-O
DH-H PROPN B-AC
] PUNCT B-O
) PUNCT B-O
was AUX B-O
12 NUM B-O
± SYM B-O
3 NUM B-O
nm NOUN B-O
( PUNCT B-O
mean ADJ B-O
± SYM B-O
SD NOUN B-O
) PUNCT B-O
, PUNCT B-O
whereas SCONJ B-O
, PUNCT B-O
after ADP B-O
dissociation NOUN B-O
, PUNCT B-O
the DET B-O
mean ADJ B-O
DH PROPN B-AC
increased VERB B-O
to ADP B-O
16 NUM B-O
nm NOUN B-O
, PUNCT B-O
with ADP B-O
a DET B-O
larger ADJ B-O
standard ADJ B-O
deviation NOUN B-O
of ADP B-O
6 NUM B-O
nm NOUN B-O
( PUNCT B-O
Fig PROPN B-O
6D NUM B-O
and CCONJ B-O
6E NUM B-O
; PUNCT B-O
for ADP B-O
additional ADJ B-O
movies NOUN B-O
and CCONJ B-O
head NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
head NOUN I-LF
distance NOUN I-LF
measurements NOUN B-O
, PUNCT B-O
S11 PROPN B-O
Movie PROPN B-O
and CCONJ B-O
S4A PROPN B-O
– PUNCT B-O
S4C PROPN B-O
Fig PROPN B-O
, PUNCT B-O
respectively ADV B-O
) PUNCT B-O
. PUNCT B-O

Of ADP B-O
855,046 NUM B-O
sequences NOUN B-O
, PUNCT B-O
417,953 NUM B-O
with ADP B-O
useable ADJ B-O
reads NOUN B-O
were AUX B-O
assignable ADJ B-O
to ADP B-O
93 NUM B-O
operational ADJ B-LF
taxonomic ADJ I-LF
units NOUN I-LF
( PUNCT B-O
OTUs PROPN B-AC
) PUNCT B-O
consisting VERB B-O
of ADP B-O
80 NUM B-O
OTUs PROPN B-AC
of ADP B-O
bacteria NOUN B-O
, PUNCT B-O
12 NUM B-O
OTUs PROPN B-AC
of ADP B-O
hamster NOUN B-O
DNA NOUN B-O
, PUNCT B-O
and CCONJ B-O
one NUM B-O
OTU PROPN B-AC
of ADP B-O
plant NOUN B-O
origin NOUN B-O
. PUNCT B-O

A DET B-O
1.0 NUM B-O
m NOUN B-O
above ADP B-LF
- PUNCT I-LF
ground NOUN I-LF
biomass NOUN I-LF
( PUNCT B-O
AGBM PROPN B-AC
) PUNCT B-O
sample NOUN B-O
was AUX B-O
cut VERB B-O
from ADP B-O
the DET B-O
center NOUN B-O
row NOUN B-O
of ADP B-O
each DET B-O
plot NOUN B-O
at ADP B-O
harvest NOUN B-O
maturity NOUN B-O
( PUNCT B-O
grain NOUN B-O
moisture NOUN B-O
concentration NOUN B-O
≤ PUNCT B-O
160 NUM B-O
g NOUN B-O
kg-1 NUM B-O
) PUNCT B-O
in ADP B-O
all DET B-O
testing NOUN B-O
environments NOUN B-O
. PUNCT B-O

Cathepsin PROPN B-LF
D PROPN I-LF
( PUNCT B-O
CD PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
lysosomal ADJ B-O
protease NOUN B-O
previously ADV B-O
demonstrated VERB B-O
to PART B-O
cleave VERB B-O
α PUNCT B-O
- NOUN B-O
syn NOUN B-O
and CCONJ B-O
decrease VERB B-O
its PRON B-O
toxicity NOUN B-O
in ADP B-O
cell NOUN B-O
lines NOUN B-O
[ PUNCT B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

This PRON B-O
is AUX B-O
promising ADJ B-O
especially ADV B-O
concerning VERB B-O
cardiomyocyte NOUN B-O
damage NOUN B-O
following VERB B-O
myocardial ADJ B-LF
infarction NOUN I-LF
( PUNCT B-O
MI PROPN B-AC
) PUNCT B-O
or CCONJ B-O
heart NOUN B-O
failure NOUN B-O
in ADP B-O
CVD PROPN B-AC
patients NOUN B-O
. PUNCT B-O

Liver PROPN B-O
disease NOUN B-O
severity NOUN B-O
was AUX B-O
assessed VERB B-O
using VERB B-O
the DET B-O
Child PROPN B-LF
Pugh PROPN I-LF
Score PROPN I-LF
( PUNCT B-O
CPS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Model PROPN B-LF
for ADP I-LF
End PROPN I-LF
- PUNCT I-LF
stage NOUN I-LF
Liver PROPN I-LF
Disease PROPN I-LF
( PUNCT B-O
MELD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
medical ADJ B-O
comorbidities NOUN B-O
were AUX B-O
assessed VERB B-O
using VERB B-O
the DET B-O
Charlson PROPN B-LF
Comorbidity PROPN I-LF
Index PROPN I-LF
( PUNCT B-O
CCI PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
11 NUM B-O
] PUNCT B-O
. PUNCT B-O

An DET B-O
analysis NOUN B-O
of ADP B-O
microtubule NOUN B-LF
associated VERB I-LF
protein NOUN I-LF
2 NUM I-LF
( PUNCT B-O
MAP2)- PROPN B-AC
and CCONJ B-O
Nissl PROPN B-O
- ADJ B-O
stained VERB B-O
Ngl3−/− PROPN B-O
slices NOUN B-O
revealed VERB B-O
that SCONJ B-O
the DET B-O
gross ADJ B-O
morphology NOUN B-O
of ADP B-O
the DET B-O
Ngl3−/−(Hyb PROPN B-O
) PUNCT B-O
brain NOUN B-O
was AUX B-O
largely ADV B-O
normal ADJ B-O
, PUNCT B-O
except SCONJ B-O
for ADP B-O
an DET B-O
apparent ADJ B-O
decrease NOUN B-O
in ADP B-O
the DET B-O
size NOUN B-O
of ADP B-O
the DET B-O
thalamus NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1F NUM B-O
and CCONJ B-O
1 NUM B-O
G NOUN B-O
) PUNCT B-O
. PUNCT B-O

Levels NOUN B-O
of ADP B-O
NGL-3 PROPN B-AC
relatives NOUN B-O
( PUNCT B-O
NGL-1 PROPN B-O
and CCONJ B-O
NGL-2 PROPN B-O
) PUNCT B-O
were AUX B-O
normal ADJ B-O
in ADP B-O
the DET B-O
Ngl3−/−(Hyb PROPN B-O
) PUNCT B-O
brains NOUN B-O
( PUNCT B-O
3 NUM B-O
and CCONJ B-O
10 NUM B-O
weeks NOUN B-O
) PUNCT B-O
, PUNCT B-O
although SCONJ B-O
levels NOUN B-O
of ADP B-O
PTPδ PROPN B-AC
, PUNCT B-O
a DET B-O
trans ADJ B-O
- ADJ B-O
synaptic ADJ B-O
partner NOUN B-O
of ADP B-O
NGL-3 PROPN B-AC
, PUNCT B-O
were AUX B-O
reduced VERB B-O
( PUNCT B-O
S2 PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

IFOF PROPN B-AC
, PUNCT B-O
inferior ADJ B-LF
fronto ADJ I-LF
- PUNCT I-LF
occipital ADJ I-LF
fascicle NOUN I-LF
; PUNCT B-O
ILF PROPN B-AC
, PUNCT B-O
inferior ADJ B-LF
longitudinal ADJ I-LF
fascicle NOUN I-LF
; PUNCT B-O
ILFlat PROPN B-AC
, PUNCT B-O
inferior ADJ B-LF
longitudinal ADJ I-LF
fascicle NOUN I-LF
lateral ADJ B-O
; PUNCT B-O
ILFmed PROPN B-AC
, PUNCT B-O
inferior ADJ B-LF
longitudinal ADJ I-LF
fascicle NOUN I-LF
medial ADJ B-O
; PUNCT B-O
MdLF PROPN B-AC
, PUNCT B-O
middle ADJ B-LF
longitudinal ADJ I-LF
fascicle NOUN I-LF
; PUNCT B-O
PRIME PROPN B-O
- PUNCT B-O
DE PROPN B-O
, PUNCT B-O
Primate PROPN B-O
Data PROPN B-O
Exchange PROPN B-O
. PUNCT B-O

Recent ADJ B-O
work NOUN B-O
suggests VERB B-O
that SCONJ B-O
a DET B-O
T NOUN B-O
cell NOUN B-O
- PUNCT B-O
based VERB B-O
assay NOUN B-O
for ADP B-O
interferon NOUN B-O
gamma NOUN B-O
, PUNCT B-O
the DET B-O
enzyme NOUN B-LF
- PUNCT I-LF
linked VERB I-LF
immunosorbent ADJ I-LF
spot NOUN I-LF
test NOUN I-LF
( PUNCT B-O
ELISPOT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
has VERB B-O
promise NOUN B-O
in ADP B-O
the DET B-O
diagnosis NOUN B-O
of ADP B-O
Mycobacterium PROPN B-O
tuberculosis NOUN B-LF
infection NOUN B-O
after ADP B-O
exposure NOUN B-O
to ADP B-O
a DET B-O
known VERB B-O
tuberculosis NOUN B-LF
( PUNCT B-O
TB PROPN B-AC
) PUNCT B-O
patient NOUN B-O
[ X B-O
1–3 NUM B-O
] PUNCT B-O
. PUNCT B-O

NB PROPN B-O
: PUNCT B-O
GLIA PROPN B-AC
: PUNCT B-O
Guideline PROPN B-LF
Implementability PROPN I-LF
Appraisal PROPN I-LF
, PUNCT B-O
SD PROPN B-O
: PUNCT B-O
standard ADJ B-O
deviation NOUN B-O
, PUNCT B-O
% NOUN B-O
age NOUN B-O
score NOUN B-O
: PUNCT B-O
percentage NOUN B-O
score NOUN B-O
EF PROPN B-O
– PUNCT B-O
Ejection PROPN B-O
Fraction PROPN B-O
, PUNCT B-O
EDV PROPN B-O
– PUNCT B-O
End PROPN B-O
diastolic ADJ B-O
volume NOUN B-O
index NOUN B-O
, PUNCT B-O
ESVI PROPN B-O
– PUNCT B-O
End PROPN B-O
systolic ADJ B-O
volume NOUN B-O
index NOUN B-O
, PUNCT B-O
LV PROPN B-AC
– PUNCT B-O
left ADJ B-LF
ventricle NOUN I-LF
, PUNCT B-O
RV NOUN B-O
– PUNCT B-O
right ADJ B-O
ventricle NOUN B-O
, PUNCT B-O
SVI NOUN B-O
– PUNCT B-O
stroke NOUN B-O
volume NOUN B-O
. PUNCT B-O

The DET B-O
surface NOUN B-O
- PUNCT B-O
exposed VERB B-O
P2 NOUN B-O
subdomain NOUN B-O
( PUNCT B-O
residues NOUN B-O
279–405 NUM B-O
) PUNCT B-O
[ X B-O
17 X B-O
] PUNCT B-O
interacts VERB B-O
with ADP B-O
histoblood NOUN B-LF
group NOUN I-LF
antigens NOUN I-LF
( PUNCT B-O
HBGAs PROPN B-AC
) PUNCT B-O
expressed VERB B-O
on ADP B-O
gut ADJ B-O
epithelial ADJ B-O
cells NOUN B-O
, PUNCT B-O
facilitating VERB B-O
virus NOUN B-O
binding NOUN B-O
and CCONJ B-O
entry NOUN B-O
resulting VERB B-O
in ADP B-O
infection NOUN B-O
[ X B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

Within ADP B-O
the DET B-O
ALs PROPN B-AC
, PUNCT B-O
the DET B-O
olfactory ADJ B-O
information NOUN B-O
is AUX B-O
processed VERB B-O
by ADP B-O
a DET B-O
complex ADJ B-O
network NOUN B-O
of ADP B-O
neurons NOUN B-O
, PUNCT B-O
including VERB B-O
OSNs PROPN B-AC
, PUNCT B-O
local ADJ B-LF
interneurons NOUN I-LF
( PUNCT B-O
LNs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
projection NOUN B-LF
neurons NOUN I-LF
( PUNCT B-O
PNs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
centrifugal ADJ B-LF
neurons NOUN I-LF
( PUNCT B-O
CNs PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

Genetic ADJ B-O
- PUNCT B-O
variation NOUN B-O
studies NOUN B-O
have AUX B-O
primarily ADV B-O
been AUX B-O
focused VERB B-O
on ADP B-O
tumor NOUN B-O
somatic ADJ B-O
mutations NOUN B-O
or CCONJ B-O
on ADP B-O
germline ADJ B-O
single ADJ B-LF
- PUNCT I-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT B-O
SNPs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

AID PROPN B-AC
, PUNCT B-O
auxin NOUN B-LF
- PUNCT I-LF
inducible ADJ I-LF
degron NOUN I-LF
; PUNCT B-O
CENP PROPN B-AC
, PUNCT B-O
centromere NOUN B-LF
protein NOUN I-LF
A NOUN I-LF
; PUNCT B-O
-AFL PROPN B-AC
, PUNCT B-O
full ADJ B-LF
- PUNCT I-LF
length NOUN I-LF
; PUNCT B-O
IF PROPN B-AC
, PUNCT B-O
immunofluorescence NOUN B-LF
; PUNCT B-O
RNAi PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT B-O
WT PROPN B-O
, PUNCT B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
delineate VERB B-O
the DET B-O
complex ADJ B-O
relationship NOUN B-O
among ADP B-O
chain NOUN B-O
connectivity NOUN B-O
, PUNCT B-O
protein NOUN B-O
folding NOUN B-O
, PUNCT B-O
coupled VERB B-O
networks NOUN B-O
, PUNCT B-O
and CCONJ B-O
catalysis NOUN B-O
by ADP B-O
DHFR PROPN B-AC
, PUNCT B-O
we PRON B-O
have AUX B-O
carried VERB B-O
out ADP B-O
a DET B-O
systematic ADJ B-O
network NOUN B-O
analysis NOUN B-O
and CCONJ B-O
molecular ADJ B-LF
dynamics NOUN I-LF
( PUNCT B-O
MD PROPN B-AC
) PUNCT B-O
simulations NOUN B-O
of ADP B-O
the DET B-O
native ADJ B-O
( PUNCT B-O
closed ADJ B-O
state NOUN B-O
) PUNCT B-O
DHFR PROPN B-AC
and CCONJ B-O
19 NUM B-O
of ADP B-O
its PRON B-O
circularly ADV B-O
permuted ADJ B-O
variants NOUN B-O
. PUNCT B-O

Cervical ADJ B-O
cancer NOUN B-O
is AUX B-O
mainly ADV B-O
caused VERB B-O
by ADP B-O
sexually ADV B-O
transmitted VERB B-O
Human PROPN B-LF
Papilloma PROPN I-LF
Virus PROPN I-LF
( PUNCT B-O
HPV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
the DET B-O
most ADV B-O
common ADJ B-O
viral ADJ B-O
infection NOUN B-O
of ADP B-O
the DET B-O
female ADJ B-O
reproductive ADJ B-O
tract NOUN B-O
. PUNCT B-O

Combining VERB B-O
sensitivity NOUN B-O
and CCONJ B-O
specificity NOUN B-O
, PUNCT B-O
we PRON B-O
calculated VERB B-O
likelihood NOUN B-LF
ratios NOUN I-LF
( PUNCT B-O
LR PROPN B-AC
) PUNCT B-O
for ADP B-O
different ADJ B-O
cut VERB B-O
- PUNCT B-O
off ADP B-O
points NOUN B-O
. PUNCT B-O

MDA PROPN B-AC
levels NOUN B-O
in ADP B-O
cell NOUN B-O
lysates NOUN B-O
were AUX B-O
determined VERB B-O
by ADP B-O
high ADJ B-LF
- PUNCT I-LF
performance NOUN I-LF
liquid NOUN I-LF
chromatography NOUN I-LF
( PUNCT B-O
HPLC PROPN B-AC
) PUNCT B-O
as SCONJ B-O
shown VERB B-O
previously ADV B-O
[ X B-O
31 NUM B-O
] PUNCT B-O
. PUNCT B-O

At ADP B-O
the DET B-O
end NOUN B-O
of ADP B-O
the DET B-O
study NOUN B-O
, PUNCT B-O
CO NOUN B-O
concentration NOUN B-O
in ADP B-O
the DET B-O
exhaled VERB B-O
gas NOUN B-O
of ADP B-O
each DET B-O
participant NOUN B-O
was AUX B-O
measured VERB B-O
, PUNCT B-O
and CCONJ B-O
indoor ADJ B-O
air NOUN B-O
pollutants NOUN B-O
( PUNCT B-O
i.e. X B-O
, PUNCT B-O
SO2 NOUN B-O
, PUNCT B-O
CO NOUN B-O
, PUNCT B-O
CO2 NOUN B-O
, PUNCT B-O
NO2 NOUN B-O
, PUNCT B-O
and CCONJ B-O
particulate NOUN B-LF
matter NOUN I-LF
with ADP I-LF
an DET I-LF
aerodynamic ADJ I-LF
diameter NOUN I-LF
of ADP I-LF
10 NUM I-LF
µm NOUN I-LF
or CCONJ I-LF
less ADJ I-LF
[ PUNCT B-O
PM10 PROPN B-AC
] PUNCT B-O
) PUNCT B-O
were AUX B-O
measured VERB B-O
for ADP B-O
one NUM B-O
- PUNCT B-O
third NOUN B-O
of ADP B-O
the DET B-O
participants NOUN B-O
' PART B-O
homes NOUN B-O
, PUNCT B-O
which PRON B-O
were AUX B-O
randomly ADV B-O
selected VERB B-O
through ADP B-O
a DET B-O
systematic ADJ B-O
random ADJ B-O
process NOUN B-O
as SCONJ B-O
previously ADV B-O
described VERB B-O
for ADP B-O
the DET B-O
baseline NOUN B-O
survey NOUN B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
RNA NOUN B-LF
interference NOUN I-LF
( PUNCT B-O
RNAi PROPN B-AC
) PUNCT B-O
to PART B-O
systematically ADV B-O
investigate VERB B-O
the DET B-O
roles NOUN B-O
of ADP B-O
Acps PROPN B-AC
in ADP B-O
inducing VERB B-O
changes NOUN B-O
in ADP B-O
egg NOUN B-O
laying NOUN B-O
, PUNCT B-O
fertility NOUN B-O
, PUNCT B-O
receptivity NOUN B-O
, PUNCT B-O
and CCONJ B-O
sperm NOUN B-O
storage NOUN B-O
. PUNCT B-O

Over ADP B-O
recent ADJ B-O
years NOUN B-O
, PUNCT B-O
the DET B-O
use NOUN B-O
of ADP B-O
novel ADJ B-O
agents NOUN B-O
( PUNCT B-O
immunomodulatory ADJ B-O
drugs NOUN B-O
[ X B-O
lenalidomide NOUN B-O
, PUNCT B-O
thalidomide NOUN B-O
and CCONJ B-O
pomalidomide NOUN B-O
] PUNCT B-O
and CCONJ B-O
the DET B-O
proteasome NOUN B-O
inhibitor NOUN B-O
[ X B-O
bortezomib NOUN B-O
] PUNCT B-O
) PUNCT B-O
and CCONJ B-O
autologous ADJ B-LF
stem NOUN I-LF
cell NOUN I-LF
transplant NOUN I-LF
( PUNCT B-O
ASCT PROPN B-AC
) PUNCT B-O
in ADP B-O
patients NOUN B-O
eligible ADJ B-O
for ADP B-O
transplant NOUN B-O
has AUX B-O
improved VERB B-O
the DET B-O
outcomes NOUN B-O
of ADP B-O
patients NOUN B-O
with ADP B-O
MM PROPN B-AC
around ADP B-O
the DET B-O
world NOUN B-O
[ X B-O
2–6 NUM B-O
] PUNCT B-O
. PUNCT B-O

Apnea NOUN B-LF
- NOUN I-LF
Hypopnea NOUN I-LF
index NOUN I-LF
( PUNCT B-O
AHI PROPN B-AC
) PUNCT B-O
or CCONJ B-O
oxygen NOUN B-LF
de NOUN I-LF
- NOUN I-LF
saturation NOUN I-LF
index NOUN I-LF
( PUNCT B-O
ODI PROPN B-AC
) PUNCT B-O
were AUX B-O
also ADV B-O
independent ADJ B-O
factors NOUN B-O
of ADP B-O
DNA NOUN B-O
methylation NOUN B-O
levels NOUN B-O
of ADP B-O
the DET B-O
TLR2 NOUN B-O
promoter NOUN B-O
region NOUN B-O
, PUNCT B-O
TLR6 NOUN B-O
gene NOUN B-O
body NOUN B-O
, PUNCT B-O
and CCONJ B-O
protein NOUN B-O
expressions NOUN B-O
of ADP B-O
TLR6 NOUN B-O
( PUNCT B-O
S4 PROPN B-O
and CCONJ B-O
S5 PROPN B-O
Tables NOUN B-O
) PUNCT B-O
. PUNCT B-O

Subgroup NOUN B-O
comparisons NOUN B-O
of ADP B-O
the DET B-O
weighted VERB B-O
mean ADJ B-O
difference NOUN B-O
of ADP B-O
diastolic ADJ B-O
blood NOUN B-O
pressure NOUN B-O
between ADP B-O
South PROPN B-LF
Asians PROPN I-LF
( PUNCT B-O
SA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
European ADJ B-O
participants NOUN B-O
( PUNCT B-O
EU PROPN B-AC
) PUNCT B-O
by ADP B-O
country NOUN B-O
of ADP B-O
origin NOUN B-O
. PUNCT B-O

Quantitative ADJ B-O
measurement NOUN B-O
of ADP B-O
lipid NOUN B-O
peroxidation NOUN B-O
was AUX B-O
performed VERB B-O
in ADP B-O
cell NOUN B-O
homogenates NOUN B-O
according VERB B-O
to ADP B-O
the DET B-O
methods NOUN B-O
of ADP B-O
Tappel PROPN B-O
and CCONJ B-O
Zalkin PROPN B-O
, PUNCT B-O
1959 NUM B-O
[ PUNCT B-O
33 NUM B-O
] PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
based VERB B-O
on ADP B-O
the DET B-O
formation NOUN B-O
of ADP B-O
thiobarbituric NOUN B-LF
acid NOUN I-LF
reactive ADJ I-LF
substances NOUN I-LF
( PUNCT B-O
TBARS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
expressed VERB B-O
as ADP B-O
the DET B-O
extent NOUN B-O
of ADP B-O
malondialdehyde NOUN B-LF
( PUNCT B-O
MDA PROPN B-AC
) PUNCT B-O
production NOUN B-O
. PUNCT B-O

All DET B-O
villages NOUN B-O
were AUX B-O
Primary PROPN B-LF
Health PROPN I-LF
Care PROPN I-LF
Programme PROPN I-LF
( PUNCT B-O
PHC PROPN B-AC
) PUNCT B-O
villages NOUN B-O
and CCONJ B-O
had AUX B-O
a DET B-O
male ADJ B-O
village NOUN B-LF
health NOUN I-LF
worker NOUN I-LF
( PUNCT B-O
VHW PROPN B-AC
) PUNCT B-O
and CCONJ B-O
a DET B-O
traditional ADJ B-LF
birth NOUN I-LF
attendant NOUN I-LF
( PUNCT B-O
TBA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
both PRON B-O
of ADP B-O
whom PRON B-O
had AUX B-O
completed VERB B-O
a DET B-O
4 NUM B-O
- PUNCT B-O
week NOUN B-O
Gambian ADJ B-O
Ministry PROPN B-O
of ADP B-O
Health PROPN B-O
( PUNCT B-O
MoH PROPN B-O
) PUNCT B-O
training NOUN B-O
programme NOUN B-O
. PUNCT B-O

E10.5 PROPN B-AC
, PUNCT B-O
embryonic ADJ B-LF
day NOUN I-LF
10.5 NUM I-LF
; PUNCT B-O
E11.5 PROPN B-AC
, PUNCT B-O
embryonic ADJ B-LF
day NOUN I-LF
11.5 NUM I-LF
; PUNCT B-O
EP PROPN B-O
, PUNCT B-O
embryo NOUN B-O
proper ADJ B-O
; PUNCT B-O
HM PROPN B-O
Ripk1D325A PROPN B-O
/ SYM B-O
D325A NOUN B-O
homozygotes NOUN B-O
; PUNCT B-O
NF PROPN B-AC
, PUNCT B-O
nuclear ADJ B-LF
factor NOUN I-LF
- PUNCT I-LF
kappa NOUN I-LF
B NOUN I-LF
; PUNCT B-O
-κBWT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
; PUNCT B-O
YS NOUN B-O
, PUNCT B-O
yolk NOUN B-O
sac NOUN B-O
. PUNCT B-O

These DET B-O
PRRs PROPN B-AC
include VERB B-O
Toll NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
receptors NOUN I-LF
( PUNCT B-O
TLRs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
receptor NOUN B-LF
for ADP I-LF
advanced ADJ I-LF
glycation NOUN I-LF
end NOUN I-LF
products NOUN I-LF
( PUNCT B-O
RAGE PROPN B-AC
) PUNCT B-O
and CCONJ B-O
scavenger NOUN B-O
receptors NOUN B-O
[ PUNCT B-O
59–61 NUM B-O
] PUNCT B-O
. PUNCT B-O

B. PROPN B-O
malayi NOUN B-O
microfilaria NOUN B-O
worms NOUN B-O
were AUX B-O
purchased VERB B-O
from ADP B-O
TRS PROPN B-O
Labs PROPN B-O
( PUNCT B-O
Athens PROPN B-O
, PUNCT B-O
GA PROPN B-O
, PUNCT B-O
United PROPN B-O
States PROPN B-O
) PUNCT B-O
for ADP B-O
preparation NOUN B-O
of ADP B-O
DNA NOUN B-O
. PUNCT B-O

Because SCONJ B-O
of ADP B-O
the DET B-O
difficulties NOUN B-O
in ADP B-O
obtaining VERB B-O
purified ADJ B-O
Wolbachia PROPN B-O
DNA NOUN B-O
from ADP B-O
the DET B-O
B. PROPN B-O
malayi NOUN B-O
host NOUN B-O
, PUNCT B-O
bacterial ADJ B-LF
artificial ADJ I-LF
chromosome NOUN I-LF
( PUNCT B-O
BAC PROPN B-AC
) PUNCT B-O
libraries NOUN B-O
were AUX B-O
created VERB B-O
[ PUNCT B-O
114 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
treatment NOUN B-O
regimen NOUN B-O
developed VERB B-O
from ADP B-O
this DET B-O
dose NOUN B-O
- ADJ B-O
finding VERB B-O
study NOUN B-O
has AUX B-O
now ADV B-O
been AUX B-O
carried VERB B-O
forward ADV B-O
into ADP B-O
the DET B-O
DIABIL-2 PROPN B-O
clinical ADJ B-O
trial NOUN B-O
to PART B-O
assess VERB B-O
the DET B-O
efficacy NOUN B-O
and CCONJ B-O
safety NOUN B-O
of ADP B-O
ultra ADJ B-O
- ADJ B-O
low ADJ B-O
doses NOUN B-O
of ADP B-O
recombinant ADJ B-LF
human ADJ I-LF
IL-2 NOUN I-LF
( PUNCT B-O
rhIL-2 PROPN B-AC
) PUNCT B-O
in ADP B-O
children NOUN B-O
and CCONJ B-O
adults NOUN B-O
with ADP B-O
T1D PROPN B-AC
[ PUNCT B-O
37 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
516 NUM B-O
conceptus NOUN B-O
cells NOUN B-O
consist VERB B-O
of ADP B-O
cells NOUN B-O
of ADP B-O
EPI PROPN B-AC
, PUNCT B-O
primitive ADJ B-LF
endoderm NOUN I-LF
( PUNCT B-O
PE PROPN B-AC
) PUNCT B-O
and CCONJ B-O
TE PROPN B-AC
lineages NOUN B-O
. PUNCT B-O

In ADP B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
animals NOUN B-O
, PUNCT B-O
mutation NOUN B-O
or CCONJ B-O
RNA NOUN B-LF
interference NOUN I-LF
( PUNCT B-O
RNAi PROPN B-AC
) PUNCT B-O
of ADP B-O
individual ADJ B-O
Wnt PROPN B-O
genes NOUN B-O
did AUX B-O
not PART B-O
reduce VERB B-O
the DET B-O
normal ADJ B-O
frequency NOUN B-O
of ADP B-O
vulval ADJ B-O
fates NOUN B-O
( PUNCT B-O
Table PROPN B-O
2 NUM B-O
) PUNCT B-O
. PUNCT B-O

Beyond ADP B-O
JIA PROPN B-AC
, PUNCT B-O
our PRON B-O
approach NOUN B-O
may AUX B-O
be AUX B-O
a DET B-O
transferrable ADJ B-O
template NOUN B-O
for ADP B-O
application NOUN B-O
in ADP B-O
rheumatoid ADJ B-LF
arthritis NOUN I-LF
( PUNCT B-O
RA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
spondyloarthropathies NOUN B-O
( PUNCT B-O
SpAs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Error NOUN B-O
bars NOUN B-O
indicated VERB B-O
SEM PROPN B-O
. PUNCT B-O

AAV PROPN B-AC
, PUNCT B-O
adeno NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
virus NOUN I-LF
; PUNCT B-O
ANOVA PROPN B-AC
, PUNCT B-O
Analysis PROPN B-LF
of ADP I-LF
Variance NOUN I-LF
; PUNCT B-O
DHPG PROPN B-AC
, PUNCT B-O
( PUNCT B-O
S)-3,5 NOUN B-O
- PUNCT B-O
Dihydroxyphenylglycine NOUN B-O
; PUNCT B-O
GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
GlyR PROPN B-AC
, PUNCT B-O
glycine NOUN B-LF
receptor NOUN I-LF
; PUNCT B-O
IPSC PROPN B-AC
, PUNCT B-O
inhibitory ADJ B-LF
postsynaptic ADJ I-LF
current NOUN I-LF
; PUNCT B-O
mIPSC PROPN B-AC
, PUNCT B-O
miniature ADJ B-LF
IPSC NOUN I-LF
IPSC PROPN B-AC
; PUNCT B-O
NC PROPN B-AC
, PUNCT B-O
negative ADJ B-LF
control NOUN I-LF
shRNA NOUN I-LF
shRNA PROPN B-AC
; PUNCT B-O
RPM PROPN B-AC
, PUNCT B-O
rounds NOUN B-LF
per ADP I-LF
minute NOUN I-LF
; PUNCT B-O
shRNA PROPN B-AC
, PUNCT B-O
short ADJ B-LF
hairpin NOUN I-LF
RNA NOUN I-LF
. PUNCT B-O

The DET B-O
WHO PROPN B-O
group NOUN B-O
wanted VERB B-O
to ADP B-O
know VERB B-O
how SCONJ B-O
these DET B-O
treatments NOUN B-O
affected VERB B-O
the DET B-O
virus NOUN B-O
outside ADP B-O
the DET B-O
body NOUN B-O
( PUNCT B-O
“ PUNCT B-O
in ADP B-O
vitro X B-O
” PUNCT B-O
) PUNCT B-O
and CCONJ B-O
whether SCONJ B-O
it PRON B-O
helped VERB B-O
the DET B-O
condition NOUN B-O
of ADP B-O
patients NOUN B-O
and CCONJ B-O
reduced VERB B-O
the DET B-O
death NOUN B-O
rate NOUN B-O
, PUNCT B-O
particularly ADV B-O
in ADP B-O
those DET B-O
patients NOUN B-O
who PRON B-O
developed VERB B-O
the DET B-O
dangerous ADJ B-O
complication NOUN B-O
called VERB B-O
acute ADJ B-LF
respiratory ADJ I-LF
distress NOUN I-LF
syndrome NOUN I-LF
( PUNCT B-O
ARDS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
is AUX B-O
a DET B-O
systematic ADJ B-O
review NOUN B-O
conducted VERB B-O
in ADP B-O
response NOUN B-O
to ADP B-O
the DET B-O
WHO PROPN B-O
request NOUN B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Hippo PROPN B-O
signaling NOUN B-O
pathway NOUN B-O
, PUNCT B-O
( PUNCT B-O
B X B-O
) PUNCT B-O
Focal ADJ B-O
adhesion NOUN B-O
and CCONJ B-O
( PUNCT B-O
C X B-O
) PUNCT B-O
Cell NOUN B-LF
adhesion NOUN I-LF
molecules NOUN I-LF
( PUNCT B-O
CAMs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Fluorescence NOUN B-LF
recovery NOUN I-LF
after ADP I-LF
photobleaching NOUN I-LF
( PUNCT B-O
FRAP PROPN B-AC
) PUNCT B-O
was AUX B-O
performed VERB B-O
to PART B-O
compare VERB B-O
the DET B-O
mobility NOUN B-O
and CCONJ B-O
dynamics NOUN B-O
of ADP B-O
the DET B-O
mutant ADJ B-O
variants NOUN B-O
with ADP B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
myotilin NOUN B-O
( PUNCT B-O
Fig NOUN B-O
5A NUM B-O
) PUNCT B-O
. PUNCT B-O

Wild ADJ B-O
- PUNCT B-O
type NOUN B-O
myotilin NOUN B-O
showed VERB B-O
rapid ADJ B-O
dynamics NOUN B-O
with ADP B-O
80 NUM B-O
% NOUN B-O
fluorescence NOUN B-O
recovery NOUN B-O
after ADP B-O
300 NUM B-O
s NOUN B-O
( PUNCT B-O
median ADJ B-O
half ADJ B-O
- PUNCT B-O
time NOUN B-O
t1/2 NUM B-O
of ADP B-O
72.4 NUM B-O
s NOUN B-O
) PUNCT B-O
( PUNCT B-O
Fig NOUN B-O
5B NUM B-O
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
in ADP B-O
excellent ADJ B-O
agreement NOUN B-O
with ADP B-O
previously ADV B-O
published VERB B-O
reports NOUN B-O
[ PUNCT B-O
50,51 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
ability NOUN B-O
of ADP B-O
α PUNCT B-LF
- PUNCT I-LF
methyl NOUN I-LF
- PUNCT I-LF
p NOUN I-LF
- PUNCT I-LF
tyrosine NOUN I-LF
( PUNCT B-O
αMT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
potent ADJ B-O
irreversible ADJ B-O
inhibitor NOUN B-O
of ADP B-O
TH PROPN B-AC
[ PUNCT B-O
29,45,46 NUM B-O
] PUNCT B-O
, PUNCT B-O
to PART B-O
impede VERB B-O
production NOUN B-O
of ADP B-O
brain NOUN B-O
DA PROPN B-AC
suggests VERB B-O
a DET B-O
simple ADJ B-O
, PUNCT B-O
but CCONJ B-O
straightforward ADJ B-O
, PUNCT B-O
strategy NOUN B-O
for ADP B-O
producing VERB B-O
an DET B-O
acute ADJ B-O
PD PROPN B-AC
mouse NOUN B-O
model NOUN B-O
. PUNCT B-O

In ADP B-O
this DET B-O
context NOUN B-O
, PUNCT B-O
adult NOUN B-O
bone NOUN B-O
marrow NOUN B-O
derived VERB B-O
mesenchymal ADJ B-LF
stem NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
BM-MSCs PROPN B-AC
) PUNCT B-O
represent VERB B-O
the DET B-O
most ADV B-O
studied ADJ B-O
cell NOUN B-O
type NOUN B-O
for ADP B-O
cardiac ADJ B-O
repair NOUN B-O
due ADP B-O
to ADP B-O
their PRON B-O
unique ADJ B-O
features NOUN B-O
including VERB B-O
the DET B-O
ease NOUN B-O
in ADP B-O
their PRON B-O
isolation NOUN B-O
/ SYM B-O
expansion NOUN B-O
, PUNCT B-O
their PRON B-O
paracrine NOUN B-O
activity NOUN B-O
to ADP B-O
induce VERB B-O
neovascularization ADJ B-O
post ADJ B-O
ischemic ADJ B-O
injury NOUN B-O
and CCONJ B-O
most ADV B-O
importantly ADV B-O
due ADP B-O
to ADP B-O
their PRON B-O
immunomodulatory ADJ B-O
properties NOUN B-O
[ X B-O
1–5 NUM B-O
] PUNCT B-O
. PUNCT B-O

Arrow NOUN B-O
indicates VERB B-O
BRCA2 PROPN B-O
deficiency NOUN B-O
threshold NOUN B-O
. PUNCT B-O

( PUNCT B-O
C X B-O
) PUNCT B-O
Number NOUN B-O
of ADP B-O
silent ADJ B-O
or CCONJ B-O
non ADJ B-O
- PUNCT B-O
silent ADJ B-O
mutations NOUN B-O
, PUNCT B-O
mutation NOUN B-O
signatures NOUN B-O
, PUNCT B-O
and CCONJ B-O
BRCA PROPN B-O
deficiency NOUN B-O
in ADP B-O
TCGA PROPN B-AC
TNBCs PROPN B-AC
. PUNCT B-O

BRCA-D PROPN B-AC
, PUNCT B-O
BRCA PROPN B-LF
- PUNCT I-LF
deficient ADJ I-LF
; PUNCT B-O
BRCA PROPN B-AC
, PUNCT B-O
BRCA PROPN B-LF
- PUNCT I-LF
normal ADJ I-LF
; PUNCT B-O
CNV PROPN B-O
, PUNCT B-O
copy NOUN B-O
number NOUN B-O
variation NOUN B-O
; PUNCT B-O
MMR PROPN B-O
, PUNCT B-O
mismatch NOUN B-O
repair NOUN B-O
; PUNCT B-O
Mut PROPN B-O
, PUNCT B-O
mutation NOUN B-O
; PUNCT B-O
SNV PROPN B-O
, PUNCT B-O
single ADJ B-O
nucleotide NOUN B-O
variant NOUN B-O
; PUNCT B-O
-NTCGA PROPN B-AC
, PUNCT B-O
The PRON B-LF
Cancer PROPN I-LF
Genome PROPN I-LF
Atlas PROPN I-LF
; PUNCT B-O
TNBC PROPN B-AC
, PUNCT B-O
triple ADV B-LF
negative ADJ I-LF
breast NOUN I-LF
cancer NOUN I-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT B-O

The DET B-O
Circumplex PROPN B-LF
of ADP I-LF
Interpersonal PROPN I-LF
Problems PROPN I-LF
( PUNCT B-O
CIP PROPN B-AC
) PUNCT B-O
[ X B-O
64 X B-O
] X B-O
was AUX B-O
used VERB B-O
to PART B-O
assess VERB B-O
interpersonal ADJ B-O
personal ADJ B-O
problems NOUN B-O
. PUNCT B-O

Data NOUN B-O
can AUX B-O
be AUX B-O
made VERB B-O
available ADJ B-O
by ADP B-O
the DET B-O
Health PROPN B-LF
Informatics PROPN I-LF
Centre PROPN I-LF
, PUNCT B-O
University PROPN B-O
of ADP B-O
Dundee PROPN B-O
( PUNCT B-O
contact VERB B-O
via ADP B-O
hicsupport@dundee.ac.uk X B-O
) PUNCT B-O
with ADP B-O
the DET B-O
HIC PROPN B-AC
Safe PROPN B-O
Haven PROPN B-O
for ADP B-O
researchers NOUN B-O
who PRON B-O
meet VERB B-O
the DET B-O
criteria NOUN B-O
for ADP B-O
access NOUN B-O
to ADP B-O
confidential ADJ B-O
data NOUN B-O
and CCONJ B-O
subject ADJ B-O
to ADP B-O
a DET B-O
data NOUN B-O
access NOUN B-O
fee NOUN B-O
. PUNCT B-O

Indeed ADV B-O
, PUNCT B-O
we PRON B-O
found VERB B-O
that SCONJ B-O
sperm NOUN B-O
enter VERB B-O
preferentially ADV B-O
into ADP B-O
the DET B-O
polar ADJ B-LF
body NOUN I-LF
( PUNCT B-O
pb PROPN B-AC
) PUNCT B-O
half NOUN B-O
, PUNCT B-O
except SCONJ B-O
for ADP B-O
the DET B-O
microvilli NOUN B-O
- ADJ B-O
free ADJ B-O
area NOUN B-O
directly ADV B-O
above ADP B-O
the DET B-O
metaphase NOUN B-O
chromosomes NOUN B-O
[ PUNCT B-O
11 NUM B-O
] PUNCT B-O
, PUNCT B-O
whereas SCONJ B-O
an DET B-O
earlier ADJ B-O
study NOUN B-O
reported VERB B-O
that SCONJ B-O
more ADJ B-O
sperm NOUN B-O
enter VERB B-O
in ADP B-O
the DET B-O
“ PUNCT B-O
vegetal ADJ B-O
” PUNCT B-O
area NOUN B-O
[ PUNCT B-O
10 NUM B-O
] PUNCT B-O
. PUNCT B-O

WGV PROPN B-AC
; PUNCT B-O
weight NOUN B-LF
growth NOUN I-LF
velocity NOUN I-LF
, PUNCT B-O
SD PROPN B-AC
; PUNCT B-O
standard ADJ B-LF
deviation NOUN I-LF
, PUNCT B-O
PROM PROPN B-AC
; PUNCT B-O
preterm ADJ B-LF
rupture NOUN I-LF
of ADP I-LF
membrane NOUN I-LF
, PUNCT B-O
SGA PROPN B-AC
; PUNCT B-O
small ADJ B-LF
for ADP I-LF
gestational ADJ I-LF
age NOUN I-LF
, PUNCT B-O
AS PROPN B-AC
; PUNCT B-O
Apgar PROPN B-LF
score NOUN I-LF
, PUNCT B-O
RDS PROPN B-AC
; PUNCT B-O
respiratory ADJ B-LF
distress NOUN I-LF
syndrome NOUN I-LF
, PUNCT B-O
CLD PROPN B-AC
; PUNCT B-O
chronic ADJ B-LF
lung NOUN I-LF
disease NOUN I-LF
, PUNCT B-O
PDA PROPN B-AC
; PUNCT B-O
patent NOUN B-LF
ductus NOUN I-LF
arteriosus NOUN I-LF
, PUNCT B-O
NEC PROPN B-AC
; PUNCT B-O
necrotizing VERB B-LF
enterocolitis NOUN I-LF
, PUNCT B-O
IVH PROPN B-AC
; PUNCT B-O
intraventricular ADJ B-LF
hemorrhage NOUN I-LF
. PUNCT B-O

Other ADJ B-O
information NOUN B-O
available ADJ B-O
in ADP B-O
MMBNT PROPN B-AC
’s PART B-O
dataset NOUN B-O
includes VERB B-O
: PUNCT B-O
Donor PROPN B-O
ID PROPN B-O
, PUNCT B-O
Baby PROPN B-O
Date NOUN B-LF
of ADP I-LF
Birth PROPN I-LF
( PUNCT B-O
DOB PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Baby PROPN B-O
Term PROPN B-O
( PUNCT B-O
full ADJ B-O
term NOUN B-O
, PUNCT B-O
preterm ADJ B-O
, PUNCT B-O
or CCONJ B-O
deceased ADJ B-O
) PUNCT B-O
, PUNCT B-O
Deposit NOUN B-O
Receipt PROPN B-O
Date NOUN B-O
, PUNCT B-O
Deposit NOUN B-O
Expiration NOUN B-O
Date NOUN B-O
, PUNCT B-O
and CCONJ B-O
Deposit NOUN B-O
Volume NOUN B-O
. PUNCT B-O

The DET B-O
care NOUN B-O
provided VERB B-O
by ADP B-O
skilled ADJ B-O
health NOUN B-O
care NOUN B-O
professionals NOUN B-O
to PART B-O
pregnant ADJ B-O
women NOUN B-O
and CCONJ B-O
adolescent ADJ B-O
girls NOUN B-O
in ADP B-O
order NOUN B-O
to PART B-O
ensure VERB B-O
the DET B-O
best ADJ B-O
health NOUN B-O
conditions NOUN B-O
for ADP B-O
both CCONJ B-O
mother NOUN B-O
and CCONJ B-O
baby NOUN B-O
during ADP B-O
pregnancy NOUN B-O
is AUX B-O
considered VERB B-O
Antenatal ADJ B-LF
care NOUN I-LF
( PUNCT B-O
ANC PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Tau PROPN B-O
belongs VERB B-O
to ADP B-O
the DET B-O
class NOUN B-O
of ADP B-O
natively ADV B-O
unfolded VERB B-O
proteins NOUN B-O
, PUNCT B-O
binds VERB B-O
to ADP B-O
and CCONJ B-O
stabilizes VERB B-O
microtubules NOUN B-O
, PUNCT B-O
and CCONJ B-O
partially ADV B-O
folds VERB B-O
into ADP B-O
an DET B-O
ordered ADJ B-O
β PUNCT B-O
- NOUN B-O
structure NOUN B-O
during NOUN B-O
aggregation NOUN B-O
to ADP B-O
Alzheimer PROPN B-O
paired VERB B-LF
helical ADJ I-LF
filaments NOUN I-LF
( PUNCT B-O
PHFs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
insoluble ADJ B-O
pellet NOUN B-O
or CCONJ B-O
acid NOUN B-LF
insoluble ADJ I-LF
matrix NOUN I-LF
( PUNCT B-O
AIM PROPN B-AC
) PUNCT B-O
was AUX B-O
washed VERB B-O
with ADP B-O
MilliQ PROPN B-O
water NOUN B-O
several ADJ B-O
times NOUN B-O
. PUNCT B-O

Our PRON B-O
ongoing ADJ B-O
investigations NOUN B-O
and CCONJ B-O
recently ADV B-O
published VERB B-O
reports NOUN B-O
indicated VERB B-O
that SCONJ B-O
IV NOUN B-O
formulation NOUN B-O
of ADP B-O
HET0016 PROPN B-O
with ADP B-O
2 NUM B-LF
- PUNCT I-LF
Hydroxypropyl NOUN I-LF
Beta PROPN I-LF
Cyclodextrin PROPN I-LF
( PUNCT B-O
HPßCD PROPN B-AC
) PUNCT B-O
( PUNCT B-O
HPßCD PROPN B-AC
- PUNCT B-O
HET0016 PROPN B-O
) PUNCT B-O
, PUNCT B-O
a DET B-O
20 PROPN B-AC
synthesis NOUN B-O
inhibitor NOUN B-O
, PUNCT B-O
not PART B-O
only ADV B-O
decreased VERB B-O
the DET B-O
tumor NOUN B-O
size NOUN B-O
but CCONJ B-O
also ADV B-O
inhibited VERB B-O
the DET B-O
invasiveness NOUN B-O
of ADP B-O
these DET B-O
cancer NOUN B-O
cells NOUN B-O
in ADP B-O
animal NOUN B-O
models NOUN B-O
of ADP B-O
human ADJ B-O
glioma NOUN B-O
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
and CCONJ B-O
consistent ADJ B-O
with ADP B-O
the DET B-O
recruitment NOUN B-O
of ADP B-O
attention NOUN B-O
, PUNCT B-O
functional ADJ B-LF
MRI NOUN I-LF
( PUNCT B-O
fMRI PROPN B-AC
) PUNCT B-O
analyses NOUN B-O
of ADP B-O
late ADJ B-O
learning NOUN B-O
stages NOUN B-O
showed VERB B-O
left ADJ B-O
parietal ADJ B-O
activity NOUN B-O
within ADP B-O
a DET B-O
broad ADJ B-O
bilateral ADJ B-O
dorsal ADJ B-O
frontoparietal ADJ B-O
network NOUN B-O
. PUNCT B-O

Body NOUN B-LF
surface NOUN I-LF
area NOUN I-LF
( PUNCT B-O
BSA PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
using VERB B-O
the DET B-O
formula NOUN B-O
: PUNCT B-O
0.0001 NUM B-O
x NOUN B-O
71.84 NUM B-O
x NOUN B-O
( PUNCT B-O
weight NOUN B-O
[ PUNCT B-O
kg])0.425 NUM B-O
x NOUN B-O
( PUNCT B-O
height NOUN B-O
[ PUNCT B-O
cm])0.725 NUM B-O
. PUNCT B-O

The DET B-O
PMTCT PROPN B-LF
Effectiveness PROPN I-LF
PMTCT PROPN B-AC
in ADP I-LF
Africa PROPN I-LF
: PUNCT I-LF
Research PROPN I-LF
and CCONJ I-LF
Linkages PROPN I-LF
to ADP I-LF
Care PROPN I-LF
Study PROPN I-LF
( PUNCT B-O
PEARLStudy PROPN B-AC
) PUNCT B-O
was AUX B-O
a DET B-O
multi ADJ B-O
- ADJ B-O
country ADJ B-O
evaluation NOUN B-O
of ADP B-O
the DET B-O
effectiveness NOUN B-O
of ADP B-O
PMTCT PROPN B-AC
services NOUN B-O
at ADP B-O
the DET B-O
community NOUN B-O
and CCONJ B-O
facility NOUN B-O
level NOUN B-O
. PUNCT B-O

R NOUN B-O
- PUNCT B-O
loops NOUN B-O
can AUX B-O
recruit VERB B-O
their PRON B-O
reader NOUN B-O
( PUNCT B-O
growth NOUN B-LF
arrest NOUN I-LF
and CCONJ I-LF
DNA NOUN I-LF
damage NOUN I-LF
protein NOUN I-LF
45A NOUN I-LF
[ PUNCT B-O
GADD45A PROPN B-AC
] PUNCT B-O
) PUNCT B-O
to PART B-O
promote VERB B-O
the DET B-O
demethylation NOUN B-O
pathway NOUN B-O
at ADP B-O
promoter NOUN B-O
cytosine NOUN B-LF
- PUNCT I-LF
phosphate NOUN I-LF
- PUNCT I-LF
guanine NOUN I-LF
( PUNCT B-O
CpG PROPN B-AC
) PUNCT B-O
islands NOUN B-O
in ADP B-O
human ADJ B-O
cells NOUN B-O
[ PUNCT B-O
44 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
utilized VERB B-O
multiple ADJ B-O
publicly ADV B-O
available ADJ B-O
data NOUN B-O
sources NOUN B-O
to PART B-O
evaluate VERB B-O
the DET B-O
association NOUN B-O
between ADP B-O
introduction NOUN B-O
of ADP B-O
PMI PROPN B-AC
and CCONJ B-O
child NOUN B-O
mortality NOUN B-O
rates NOUN B-O
in ADP B-O
sub ADJ B-LF
- ADJ I-LF
Saharan ADJ I-LF
Africa PROPN I-LF
( PUNCT B-O
SSA PROPN B-AC
) PUNCT B-O
. PUNCT B-O

To PART B-O
test VERB B-O
whether SCONJ B-O
hemoglobin NOUN B-O
levels NOUN B-O
were AUX B-O
significantly ADV B-O
different ADJ B-O
between ADP B-O
the DET B-O
groups NOUN B-O
we PRON B-O
used VERB B-O
a DET B-O
mixed VERB B-O
linear ADJ B-O
model NOUN B-O
that PRON B-O
adjusts VERB B-O
for ADP B-O
repeated VERB B-O
measures NOUN B-O
over ADP B-O
the DET B-O
period NOUN B-O
of ADP B-O
observation NOUN B-O
and CCONJ B-O
also ADV B-O
adjusts VERB B-O
for ADP B-O
coinfections NOUN B-O
with ADP B-O
schistosomiasis NOUN B-O
, PUNCT B-O
lymphatic ADJ B-O
filariasis NOUN B-O
and/or CCONJ B-O
hookworm NOUN B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
height NOUN B-O
and CCONJ B-O
weight NOUN B-O
measurements NOUN B-O
( PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
[ PUNCT B-O
BMI PROPN B-AC
] PUNCT B-O
, PUNCT B-O
a DET B-O
surrogate NOUN B-O
for ADP B-O
nutritional ADJ B-O
status NOUN B-O
) PUNCT B-O
from ADP B-O
each DET B-O
follow NOUN B-O
- PUNCT B-O
up NOUN B-O
. PUNCT B-O

CD59 NOUN B-O
is AUX B-O
a DET B-O
membrane NOUN B-O
complement NOUN B-O
regulatory ADJ B-O
protein NOUN B-O
that PRON B-O
is AUX B-O
attached VERB B-O
to ADP B-O
the DET B-O
cell NOUN B-O
membrane NOUN B-O
via ADP B-O
a DET B-O
glycosylphosphatidylinositol NOUN B-LF
( PUNCT B-O
GPI PROPN B-AC
) PUNCT B-O
anchor NOUN B-O
. PUNCT B-O

Leptin NOUN B-O
receptors NOUN B-O
have AUX B-O
been AUX B-O
found VERB B-O
on ADP B-O
paraventricular ADJ B-LF
nucleus NOUN I-LF
( PUNCT B-O
PVN PROPN B-AC
) PUNCT B-O
and CCONJ B-O
lateral ADJ B-LF
hypothalamic ADJ I-LF
( PUNCT B-O
LHA PROPN B-AC
) PUNCT B-O
neurons NOUN B-O
, PUNCT B-O
implicating VERB B-O
them PRON B-O
as ADP B-O
direct ADJ B-O
targets NOUN B-O
for ADP B-O
regulation NOUN B-O
by ADP B-O
circulating VERB B-O
adiposity NOUN B-O
signals NOUN B-O
. PUNCT B-O

Cadmium NOUN B-LF
( PUNCT B-O
Cd PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
developmental ADJ B-O
toxicant NOUN B-O
that PRON B-O
induces VERB B-O
fetal ADJ B-LF
growth NOUN I-LF
restriction NOUN I-LF
( PUNCT B-O
FGR PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Placental ADJ B-O
endoplasmic ADJ B-O
reticulum NOUN B-O
( PUNCT B-O
ER PROPN B-O
) PUNCT B-O
stress NOUN B-O
is AUX B-O
associated VERB B-O
with ADP B-O
FGR PROPN B-AC
. PUNCT B-O

This DET B-O
study NOUN B-O
investigated VERB B-O
the DET B-O
effects NOUN B-O
of ADP B-O
N NOUN B-LF
- PUNCT I-LF
acetylcysteine NOUN I-LF
( PUNCT B-O
NAC PROPN B-AC
) PUNCT B-O
on ADP B-O
Cd PROPN B-AC
- PUNCT B-O
induced VERB B-O
placental ADJ B-O
ER PROPN B-AC
and CCONJ B-O
stressFGR PROPN B-AC
. PUNCT B-O

Pregnant ADJ B-O
mice NOUN B-O
were AUX B-O
intraperitoneally ADV B-O
injected VERB B-O
with ADP B-O
CdCl2 PROPN B-O
daily ADV B-O
from ADP B-O
gestational ADJ B-LF
day NOUN I-LF
( PUNCT B-O
GD)13 PROPN B-AC
to ADP B-O
GD17 NUM B-O
. PUNCT B-O

Reviewer#2 NOUN B-O
: PUNCT B-O
This DET B-O
manuscript NOUN B-O
describes VERB B-O
a DET B-O
novel ADJ B-O
matrix NOUN B-LF
- PUNCT I-LF
assisted VERB I-LF
laser NOUN I-LF
desorption NOUN I-LF
/ SYM I-LF
ionization NOUN I-LF
time NOUN I-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
flight NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT B-O
MALDI-TOF-MS PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
of ADP B-O
the DET B-O
extracted VERB B-O
peptides NOUN B-O
obtained VERB B-O
from ADP B-O
Streptococcus PROPN B-O
suis PROPN B-O
, PUNCT B-O
and CCONJ B-O
in ADP B-O
particularly ADV B-O
S. PROPN B-O
suis PROPN B-O
serotype NOUN B-O
( PUNCT B-O
SS2 NOUN B-O
) PUNCT B-O
. PUNCT B-O

Replicated VERB B-O
hybridisation NOUN B-O
to ADP B-O
genomic ADJ B-O
DNA NOUN B-O
tiling NOUN B-O
arrays NOUN B-O
generated VERB B-O
a DET B-O
dataset NOUN B-O
( PUNCT B-O
Dataset PROPN B-O
S1 PROPN B-O
) PUNCT B-O
with ADP B-O
mean ADJ B-LF
enrichments NOUN I-LF
( PUNCT B-O
Mn PROPN B-AC
) PUNCT B-O
equivalent ADJ B-O
to ADP B-O
log2 NUM B-O
3.8 NUM B-O
( PUNCT B-O
14 NUM B-O
- ADJ B-O
fold ADJ B-O
) PUNCT B-O
observed VERB B-O
. PUNCT B-O

Therefore ADV B-O
, PUNCT B-O
our PRON B-O
estimates NOUN B-O
at ADP B-O
such ADJ B-O
high ADJ B-O
thresholds NOUN B-O
might AUX B-O
be AUX B-O
approximately ADV B-O
correct ADJ B-O
; PUNCT B-O
if SCONJ B-O
so ADV B-O
, PUNCT B-O
the DET B-O
accuracy NOUN B-O
of ADP B-O
homology NOUN B-O
transfer NOUN B-O
for ADP B-O
high ADJ B-O
similarity NOUN B-O
( PUNCT B-O
HVAL PROPN B-AC
> SYM B-O
40 NUM B-O
, PUNCT B-O
Percentage NOUN B-LF
sequence NOUN I-LF
IDEntity NOUN I-LF
( PUNCT B-O
PIDE PROPN B-AC
) PUNCT B-O
> SYM B-O
70 NUM B-O
) PUNCT B-O
were AUX B-O
just ADV B-O
over ADP B-O
10 NUM B-O
% NOUN B-O
( PUNCT B-O
Figure PROPN B-O
2 NUM B-O
) PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
FGC PROPN B-AC
, PUNCT B-O
female ADJ B-LF
genital ADJ I-LF
cutting NOUN I-LF
; PUNCT B-O
MoH PROPN B-AC
, PUNCT B-O
Ministry PROPN B-LF
of ADP I-LF
Health PROPN I-LF
However ADV B-O
, PUNCT B-O
type NOUN B-O
D NOUN B-O
is AUX B-O
a DET B-O
limited ADJ B-O
and CCONJ B-O
specific ADJ B-O
aspect NOUN B-O
of ADP B-O
personality NOUN B-O
, PUNCT B-O
and CCONJ B-O
currently ADV B-O
the DET B-O
Five NUM B-LF
Factor PROPN I-LF
Model PROPN I-LF
( PUNCT B-O
FFM PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
more ADV B-O
accepted ADJ B-O
, PUNCT B-O
widely ADV B-O
used VERB B-O
and CCONJ B-O
comprehensive ADJ B-O
means NOUN B-O
of ADP B-O
categorization NOUN B-O
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
presence NOUN B-O
of ADP B-O
ITPase PROPN B-AC
deficiency NOUN B-O
was AUX B-O
not PART B-O
statistically ADV B-O
associated VERB B-O
with ADP B-O
a DET B-O
lower ADJ B-O
hazard NOUN B-LF
ratio NOUN I-LF
( PUNCT B-O
HR PROPN B-AC
) PUNCT B-O
for ADP B-O
RBV PROPN B-AC
dose NOUN B-O
reductions NOUN B-O
( PUNCT B-O
HR PROPN B-AC
0.80 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
0.35–1.71 NUM B-O
, PUNCT B-O
p NOUN B-O
= SYM B-O
0.57 NUM B-O
) PUNCT B-O
. PUNCT B-O

BMP PROPN B-AC
, PUNCT B-O
Bone PROPN B-LF
Morphogenetic PROPN I-LF
Protein PROPN I-LF
; PUNCT B-O
FISH PROPN B-AC
, PUNCT B-O
fluorescent ADJ B-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
; PUNCT B-O
hpf PROPN B-AC
, PUNCT B-O
hours NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT B-O
pSmad5 PROPN B-AC
, PUNCT B-O
phosphorylated VERB B-LF
Smad5 NOUN I-LF
; PUNCT B-O
WT PROPN B-O
, PUNCT B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
. PUNCT B-O

NF-κB PROPN B-AC
dimers NOUN B-O
are AUX B-O
sequestered VERB B-O
in ADP B-O
the DET B-O
cytoplasm NOUN B-O
by ADP B-O
an DET B-O
inhibitory ADJ B-O
protein NOUN B-O
IκBα PROPN B-O
, PUNCT B-O
which PRON B-O
masks VERB B-O
the DET B-O
conserved VERB B-O
nuclear ADJ B-LF
localization NOUN I-LF
sequence NOUN I-LF
( PUNCT B-O
NLS PROPN B-AC
) PUNCT B-O
of ADP B-O
RelA PROPN B-O
/ SYM B-O
p65 NOUN B-O
to PART B-O
prevent VERB B-O
nuclear ADJ B-O
translocation NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

AMPK PROPN B-AC
, PUNCT B-O
AMP NOUN B-O
- PUNCT B-O
activated VERB B-O
protein NOUN B-O
kinase NOUN B-O
; PUNCT B-O
AUC PROPN B-AC
, PUNCT B-O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
; PUNCT B-O
Glut2 PROPN B-AC
, PUNCT B-O
glucose NOUN B-LF
transporter NOUN I-LF
2 NUM I-LF
; PUNCT B-O
GTT PROPN B-AC
, PUNCT B-O
glucose NOUN B-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT B-O
GS PROPN B-AC
, PUNCT B-O
glycogen NOUN B-LF
synthase NOUN I-LF
; PUNCT B-O
GS PROPN B-AC
- PUNCT B-O
p641 NOUN B-O
, PUNCT B-O
phospho NOUN B-O
- PUNCT B-O
glycogen NOUN B-LF
synthase NOUN I-LF
at ADP B-O
S641 NUM B-O
; PUNCT B-O
ITT PROPN B-AC
, PUNCT B-O
insulin NOUN B-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT B-O
Oct1 PROPN B-O
, PUNCT B-O
organic ADJ B-O
cation NOUN B-O
transporter NOUN B-O
1 NUM B-O
; PUNCT B-O
pACC NOUN B-O
, PUNCT B-O
phosphorylate NOUN B-O
acetyl NOUN B-O
- PUNCT B-O
CoA NOUN B-O
carboxylase NOUN B-O
; PUNCT B-O
pAMPK PROPN B-O
, PUNCT B-O
phosphorylate NOUN B-O
5 NUM B-O
' NOUN B-O
adenosine NOUN B-O
monophosphate NOUN B-O
- PUNCT B-O
activated VERB B-O
protein NOUN B-O
kinase NOUN B-O
; PUNCT B-O
PDH PROPN B-AC
, PUNCT B-O
pyruvate NOUN B-LF
dehydrogenase NOUN I-LF
; PUNCT B-O
PDH PROPN B-AC
- PUNCT B-O
p NOUN B-O
, PUNCT B-O
phospho NOUN B-O
- PUNCT B-O
pyruvate NOUN B-LF
dehydrogenase NOUN I-LF
; PUNCT B-O
PTT PROPN B-AC
, PUNCT B-O
pyruvate NOUN B-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT B-O
PYGL PROPN B-AC
; PUNCT B-O
glycogen NOUN B-LF
phosphorylase NOUN I-LF
. PUNCT B-O

Using VERB B-O
ChIP-qPCR PROPN B-AC
, PUNCT B-O
we PRON B-O
analysed VERB B-O
levels NOUN B-O
of ADP B-O
the DET B-O
active ADJ B-O
- PUNCT B-O
promoter NOUN B-O
– PUNCT B-O
associated VERB B-O
H3K4Me3 PROPN B-AC
mark NOUN B-O
and CCONJ B-O
the DET B-O
polycomb NOUN B-LF
repressor NOUN I-LF
complex NOUN I-LF
( PUNCT B-O
PRC)-associated PROPN B-AC
repressive ADJ B-O
H3K27Me3 PROPN B-AC
mark NOUN B-O
across ADP B-O
the DET B-O
HPV18 PROPN B-O
genome NOUN B-O
. PUNCT B-O

Criteria NOUN B-O
for ADP B-O
discharge NOUN B-O
were AUX B-O
the DET B-O
absence NOUN B-O
of ADP B-O
fever NOUN B-O
and CCONJ B-O
significant ADJ B-O
symptoms NOUN B-O
for ADP B-O
four NUM B-O
consecutive ADJ B-O
days NOUN B-O
, PUNCT B-O
ability NOUN B-O
to PART B-O
feed VERB B-O
and CCONJ B-O
walk VERB B-O
independently ADV B-O
, PUNCT B-O
and CCONJ B-O
two NUM B-O
consecutive ADJ B-O
negative ADJ B-O
blood NOUN B-O
reverse ADJ B-LF
EBOV PROPN B-AC
transcription NOUN I-LF
PCR NOUN I-LF
( PUNCT B-O
RT PROPN B-AC
) PUNCT B-O
tests NOUN B-O
. PUNCT B-O

p NOUN B-LF
- NOUN I-LF
p PROPN B-AC
value NOUN I-LF
Statistical PROPN B-LF
Package PROPN I-LF
for ADP I-LF
the DET I-LF
Social PROPN I-LF
Sciences PROPN I-LF
( PUNCT B-O
SPSS PROPN B-AC
17.0 NUM B-O
) PUNCT B-O
was AUX B-O
used VERB B-O
for ADP B-O
all DET B-O
analyses NOUN B-O
. PUNCT B-O

Length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
( PUNCT B-O
LOS PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
as ADP B-O
the DET B-O
time NOUN B-O
the DET B-O
disposition NOUN B-O
was AUX B-O
set VERB B-O
to ADP B-O
admit VERB B-O
to ADP B-O
the DET B-O
time NOUN B-O
the DET B-O
subject NOUN B-O
met VERB B-O
the DET B-O
clinical ADJ B-O
criteria NOUN B-O
for ADP B-O
discharge NOUN B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
define VERB B-O
a DET B-O
putative ADJ B-O
olfactory ADJ B-O
space NOUN B-O
for ADP B-O
the DET B-O
honeybee NOUN B-O
, PUNCT B-O
we PRON B-O
performed VERB B-O
a DET B-O
principal ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT B-O
PCA PROPN B-AC
) PUNCT B-O
on ADP B-O
our PRON B-O
data NOUN B-O
to PART B-O
represent VERB B-O
in ADP B-O
a DET B-O
limited ADJ B-O
number NOUN B-O
of ADP B-O
dimensions NOUN B-O
the DET B-O
relative ADJ B-O
relationships NOUN B-O
between ADP B-O
odorants NOUN B-O
in ADP B-O
a DET B-O
16 NUM B-O
- PUNCT B-O
dimension NOUN B-O
perceptual ADJ B-O
space NOUN B-O
( PUNCT B-O
Figure PROPN B-O
6A NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
first ADJ B-O
three NUM B-O
factors NOUN B-O
represented VERB B-O
31 NUM B-O
% PUNCT B-O
, PUNCT B-O
29 NUM B-O
% PUNCT B-O
, PUNCT B-O
and CCONJ B-O
15 NUM B-O
% PUNCT B-O
of ADP B-O
overall ADJ B-O
variance NOUN B-O
in ADP B-O
the DET B-O
data NOUN B-O
( PUNCT B-O
total NOUN B-O
of ADP B-O
the DET B-O
first ADJ B-O
three NUM B-O
factors NOUN B-O
: PUNCT B-O
75 NUM B-O
% PUNCT B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
HIV PROPN B-O
epidemic NOUN B-O
is AUX B-O
rapidly ADV B-O
growing VERB B-O
among ADP B-O
men NOUN B-LF
who PRON I-LF
have VERB I-LF
sex NOUN I-LF
with ADP I-LF
men NOUN I-LF
( PUNCT B-O
MSM PROPN B-AC
) PUNCT B-O
in ADP B-O
China PROPN B-O
, PUNCT B-O
yet CCONJ B-O
HIV PROPN B-O
testing NOUN B-O
remains VERB B-O
suboptimal ADJ B-O
. PUNCT B-O

Quality NOUN B-LF
of ADP I-LF
care NOUN I-LF
was AUX B-O
assessed VERB B-O
using VERB B-O
context NOUN B-O
based VERB B-O
validated VERB B-O
indicators NOUN B-O
which PRON B-O
provide VERB B-O
a DET B-O
more ADV B-O
detailed ADJ B-O
picture NOUN B-O
of ADP B-O
the DET B-O
state NOUN B-O
of ADP B-O
QoC PROPN B-AC
in ADP B-O
the DET B-O
process NOUN B-O
of ADP B-O
childbirth NOUN B-O
. PUNCT B-O

To PART B-O
understand VERB B-O
the DET B-O
source NOUN B-O
of ADP B-O
ROS PROPN B-AC
and CCONJ B-O
to PART B-O
determine VERB B-O
the DET B-O
association NOUN B-O
of ADP B-O
AngII PROPN B-AC
signaling NOUN B-O
, PUNCT B-O
Klf5 PROPN B-AC
, PUNCT B-O
and CCONJ B-O
eIF5α NOUN B-O
with ADP B-O
NOX PROPN B-AC
expression NOUN B-O
, PUNCT B-O
mouse NOUN B-O
VSMCs PROPN B-AC
were AUX B-O
transfected VERB B-O
with ADP B-O
expression NOUN B-O
vectors NOUN B-O
for ADP B-O
Klf5 PROPN B-AC
and CCONJ B-O
eIF5α NOUN B-O
or CCONJ B-O
small ADJ B-LF
interfering VERB I-LF
RNA NOUN I-LF
( PUNCT B-O
siRNA PROPN B-AC
) PUNCT B-O
against ADP B-O
Klf5 PROPN B-AC
and CCONJ B-O
eIF5α NOUN B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
and CCONJ B-O
then ADV B-O
treated VERB B-O
with ADP B-O
Ang PROPN B-AC
for ADP B-O
0 NUM B-O
, PUNCT B-O
1 NUM B-O
, PUNCT B-O
3 NUM B-O
, PUNCT B-O
and CCONJ B-O
5 NUM B-O
days NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
expression NOUN B-O
of ADP B-O
NOX1 NOUN B-O
and CCONJ B-O
NOX4 NOUN B-O
was AUX B-O
detected VERB B-O
by ADP B-O
RT NOUN B-O
- PUNCT B-O
qPCR NOUN B-O
. PUNCT B-O

As SCONJ B-O
shown VERB B-O
in ADP B-O
S17A PROPN B-O
– PUNCT B-O
S17D PROPN B-O
Fig PROPN B-O
, PUNCT B-O
IIAng PROPN B-AC
treatment NOUN B-O
increased VERB B-O
NOX1 NOUN B-O
expression NOUN B-O
, PUNCT B-O
peaked VERB B-O
at ADP B-O
24 NUM B-O
hours NOUN B-O
after ADP B-O
treatment NOUN B-O
, PUNCT B-O
and CCONJ B-O
gradually ADV B-O
declined VERB B-O
thereafter ADV B-O
. PUNCT B-O

terminal ADJ B-LF
λz PROPN B-AC
slope NOUN I-LF
; PUNCT B-O
AUC0-∞ NOUN B-O
area NOUN B-O
under ADP B-O
the DET B-O
curve NOUN B-O
from ADP B-O
0 NUM B-O
to ADP B-O
infinitive ADJ B-O
; PUNCT B-O
mean ADJ B-LF
MTT PROPN B-AC
transit NOUN I-LF
time NOUN I-LF
; PUNCT B-O
Tmax PROPN B-AC
time NOUN B-O
at ADP B-O
maximum ADJ B-LF
concentration NOUN I-LF
; PUNCT B-O
maximum ADJ B-LF
Cmax PROPN B-AC
concentration NOUN I-LF
; PUNCT B-O
F NOUN B-O
bioavailability NOUN B-O
, PUNCT B-O
was AUX B-O
calculated VERB B-O
by ADP B-O
dividing VERB B-O
the DET B-O
ratio NOUN B-O
of ADP B-O
AUC0-∞ NOUN B-O
oral ADJ B-O
by ADP B-O
the DET B-O
dose NOUN B-O
and CCONJ B-O
by ADP B-O
ratio NOUN B-O
total ADJ B-O
PTA PROPN B-AC
AUC0-∞ NOUN B-O
IV NOUN B-O
by ADP B-O
respective ADJ B-O
dose NOUN B-O
. PUNCT B-O

The DET B-O
figure NOUN B-O
illustrates VERB B-O
ErbB PROPN B-O
signaling NOUN B-O
pathway NOUN B-O
that PRON B-O
contain VERB B-O
genes NOUN B-O
that PRON B-O
are AUX B-O
targeted VERB B-O
by ADP B-O
miRNAs PROPN B-AC
which PRON B-O
regulate VERB B-O
NMT PROPN B-AC
gene NOUN B-O
. PUNCT B-O

( PUNCT B-O
EGF PROPN B-O
, PUNCT B-O
epidermal ADJ B-O
growth NOUN B-O
factor NOUN B-O
; PUNCT B-O
TGF PROPN B-O
, PUNCT B-O
transforming VERB B-O
growth NOUN B-O
factor NOUN B-O
; PUNCT B-O
BTC PROPN B-O
, PUNCT B-O
betacellulin NOUN B-O
; PUNCT B-O
HB PROPN B-O
- PUNCT B-O
EGF PROPN B-O
, PUNCT B-O
heparin NOUN B-O
- PUNCT B-O
binding VERB B-O
epidermal ADJ B-O
growth NOUN B-O
factor NOUN B-O
( PUNCT B-O
EGF)-like PROPN B-O
growth NOUN B-O
factor NOUN B-O
; PUNCT B-O
EREG PROPN B-O
, PUNCT B-O
epiregulin NOUN B-O
; PUNCT B-O
NRG1 PROPN B-O
, PUNCT B-O
neuregulin-1 NOUN B-O
; PUNCT B-O
NRG2 PROPN B-O
, PUNCT B-O
neuregulin-2 NOUN B-O
; PUNCT B-O
NRG3 PROPN B-O
, PUNCT B-O
neuregulin-3 NOUN B-O
; PUNCT B-O
NRG4 PROPN B-O
, PUNCT B-O
neuregulin-4 NOUN B-O
; PUNCT B-O
PLCγ PROPN B-O
, PUNCT B-O
phospholipase NOUN B-O
C PROPN B-O
type NOUN B-O
gamma NOUN B-O
; PUNCT B-O
CAMK2B PROPN B-O
, PUNCT B-O
calcium NOUN B-O
/ SYM B-O
calmodulin NOUN B-O
dependent ADJ B-O
protein NOUN B-O
kinase NOUN B-O
; PUNCT B-O
PRKCB PROPN B-O
, PUNCT B-O
Protein PROPN B-O
kinase NOUN B-O
C PROPN B-O
- PUNCT B-O
beta NOUN B-O
; PUNCT B-O
STAT5 PROPN B-O
, PUNCT B-O
Signal NOUN B-O
transducer NOUN B-O
and CCONJ B-O
activator NOUN B-O
of ADP B-O
transcription NOUN B-O
5 NUM B-O
; PUNCT B-O
src PROPN B-O
, PUNCT B-O
Rous PROPN B-O
sarcoma NOUN B-O
virus NOUN B-O
gene NOUN B-O
; PUNCT B-O
CRK PROPN B-O
, PUNCT B-O
C PROPN B-O
T10 NOUN B-O
regulator NOUN B-O
of ADP B-O
a DET B-O
tyrosine NOUN B-O
kinase NOUN B-O
; PUNCT B-O
NCL PROPN B-O
, PUNCT B-O
NCK PROPN B-O
Adaptor PROPN B-O
Protein PROPN B-O
2 NUM B-O
; PUNCT B-O
PTK2 PROPN B-O
, PUNCT B-O
PTK2 PROPN B-O
protein NOUN B-O
tyrosine NOUN B-O
kinase NOUN B-O
2 NUM B-O
; PUNCT B-O
ABL2 PROPN B-O
, PUNCT B-O
V PROPN B-O
- PUNCT B-O
Abl PROPN B-O
Abelson PROPN B-O
Murine PROPN B-O
Leukemia PROPN B-O
Viral PROPN B-O
Oncogene PROPN B-O
Homolog PROPN B-O
2 NUM B-O
; PUNCT B-O
PAK2 PROPN B-O
, PUNCT B-O
P21 PROPN B-O
( PUNCT B-O
RAC1 PROPN B-O
) PUNCT B-O
Activated PROPN B-O
Kinase PROPN B-O
2 NUM B-O
; PUNCT B-O
MAP2K4 PROPN B-O
, PUNCT B-O
Mitogen PROPN B-O
- PUNCT B-O
Activated PROPN B-O
Protein PROPN B-O
Kinase PROPN B-O
Kinase PROPN B-O
4 NUM B-O
; PUNCT B-O
MAPK10 PROPN B-O
, PUNCT B-O
Mitogen PROPN B-O
- PUNCT B-O
Activated PROPN B-O
Protein PROPN B-O
Kinase PROPN B-O
10 NUM B-O
; PUNCT B-O
SOS1 PROPN B-O
, PUNCT B-O
SOS PROPN B-O
Ras PROPN B-O
/ SYM B-O
Rac NOUN B-O
Guanine NOUN B-O
Nucleotide PROPN B-O
Exchange PROPN B-O
Factor PROPN B-O
1 NUM B-O
; PUNCT B-O
Grb2 PROPN B-O
, PUNCT B-O
Growth NOUN B-O
Factor PROPN B-O
Receptor NOUN B-O
Bound PROPN B-O
Protein PROPN B-O
2 NUM B-O
; PUNCT B-O
SHC4 PROPN B-O
, PUNCT B-O
Src NOUN B-O
Homology NOUN B-O
2 NUM B-O
Domain NOUN B-O
- PUNCT B-O
Containing VERB B-O
- PUNCT B-O
Transforming VERB B-O
Protein PROPN B-O
C4 PROPN B-O
; PUNCT B-O
PIK3C4 PROPN B-O
, PUNCT B-O
Phosphatidylinositol-4,5 NOUN B-O
- PUNCT B-O
Bisphosphate NOUN B-O
3 NUM B-O
- PUNCT B-O
Kinase PROPN B-O
Catalytic PROPN B-O
Subunit PROPN B-O
; PUNCT B-O
AKT3 PROPN B-O
, PUNCT B-O
KT PROPN B-O
Serine NOUN B-O
/ SYM B-O
Threonine NOUN B-O
Kinase PROPN B-O
3 NUM B-O
; PUNCT B-O
mTOR NOUN B-O
, PUNCT B-O
Mechanistic ADJ B-O
Target NOUN B-O
Of ADP B-O
Rapamycin NOUN B-O
Kinase PROPN B-O
; PUNCT B-O
BCL2 PROPN B-O
, PUNCT B-O
BCL2 PROPN B-O
Associated ADJ B-O
Agonist NOUN B-O
Of ADP B-O
Cell NOUN B-O
Death NOUN B-O
; PUNCT B-O
GSK3B PROPN B-AC
, PUNCT B-O
Glycogen NOUN B-LF
Synthase NOUN I-LF
Kinase PROPN I-LF
3 NUM I-LF
Beta PROPN I-LF
; PUNCT B-O
CDKN1A PROPN B-O
, PUNCT B-O
Cyclin NOUN B-O
Dependent PROPN B-O
Kinase PROPN B-O
Inhibitor PROPN B-O
1A PROPN B-O
; PUNCT B-O
EIF4EBP1 PROPN B-O
, PUNCT B-O
Eukaryotic ADJ B-O
Translation NOUN B-O
Initiation PROPN B-O
Factor PROPN B-O
4E NUM B-O
Binding PROPN B-O
Protein PROPN B-O
1 NUM B-O
; PUNCT B-O
BRAF PROPN B-AC
, PUNCT B-O
B PROPN B-LF
- PUNCT I-LF
Raf PROPN I-LF
Proto PROPN I-LF
- PUNCT I-LF
Oncogene PROPN I-LF
, PUNCT B-O
Serine NOUN B-O
/ SYM B-O
Threonine NOUN B-O
Kinase PROPN B-O
; PUNCT B-O
RPS6KB1 PROPN B-O
, PUNCT B-O
Ribosomal PROPN B-O
Protein PROPN B-O
S6 PROPN B-O
Kinase PROPN B-O
B1 PROPN B-O
; PUNCT B-O
KRAS PROPN B-O
, PUNCT B-O
KRAS PROPN B-O
Proto PROPN B-O
- PUNCT B-O
Oncogene PROPN B-O
, PUNCT B-O
GTPase PROPN B-O
; PUNCT B-O
JUN PROPN B-O
, PUNCT B-O
Jun PROPN B-O
Proto PROPN B-O
- PUNCT B-O
Oncogene PROPN B-O
, PUNCT B-O
AP-1 PROPN B-O
Transcription PROPN B-O
Factor PROPN B-O
Subunit PROPN B-O
; PUNCT B-O
ELK PROPN B-O
, PUNCT B-O
ETS PROPN B-O
Transcription PROPN B-O
Factor PROPN B-O
; PUNCT B-O
Myc PROPN B-O
, PUNCT B-O
MYC PROPN B-O
Proto PROPN B-O
- PUNCT B-O
Oncogene PROPN B-O
, PUNCT B-O
BHLH PROPN B-O
Transcription PROPN B-O
Factor PROPN B-O
; PUNCT B-O
ER PROPN B-O
, PUNCT B-O
endoplasmic ADJ B-O
reticulum NOUN B-O
. PUNCT B-O

To PART B-O
determine VERB B-O
whether SCONJ B-O
such ADJ B-O
target NOUN B-O
proteins NOUN B-O
could AUX B-O
be AUX B-O
identified VERB B-O
for ADP B-O
Ginir PROPN B-AC
RNA NOUN B-O
, PUNCT B-O
we PRON B-O
followed VERB B-O
the DET B-O
approach NOUN B-O
of ADP B-O
using VERB B-O
biotin NOUN B-O
- PUNCT B-O
labelled VERB B-O
RNA NOUN B-O
affinity NOUN B-O
pull VERB B-O
- PUNCT B-O
down NOUN B-O
and CCONJ B-O
RNA NOUN B-LF
- PUNCT I-LF
immunoprecipitation NOUN I-LF
( PUNCT B-O
RIP PROPN B-AC
) PUNCT B-O
assays NOUN B-O
. PUNCT B-O

This DET B-O
hyperphosphorylation NOUN B-O
causes VERB B-O
light NOUN B-O
- PUNCT B-O
dependent ADJ B-O
retinal ADJ B-O
degeneration NOUN B-O
and CCONJ B-O
premature ADJ B-O
entrance NOUN B-O
into ADP B-O
the DET B-O
prolonged VERB B-LF
depolarizing VERB I-LF
afterpotential NOUN I-LF
( PUNCT B-O
PDA PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1–3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Sirius PROPN B-O
red ADJ B-O
staining NOUN B-O
revealed VERB B-O
significantly ADV B-O
more ADJ B-O
collagen NOUN B-O
deposition NOUN B-O
in ADP B-O
the DET B-O
F-BCA PROPN B-AC
adipose ADJ B-O
tissues NOUN B-O
, PUNCT B-O
particularly ADV B-O
around ADP B-O
the DET B-O
SVF PROPN B-AC
zones NOUN B-O
( PUNCT B-O
Fig NUM B-O
6A NUM B-O
) PUNCT B-O
. PUNCT B-O

More ADV B-O
abundant ADJ B-O
type NOUN B-LF
I NOUN I-LF
collagen NOUN I-LF
( PUNCT B-O
ColI PROPN B-AC
) PUNCT B-O
expression NOUN B-O
was AUX B-O
detected VERB B-O
in ADP B-O
the DET B-O
F PROPN B-AC
-BCASVF PROPN B-AC
cells NOUN B-O
( PUNCT B-O
Fig NUM B-O
6B NUM B-O
) PUNCT B-O
, PUNCT B-O
although SCONJ B-O
the DET B-O
mRNA NOUN B-O
levels NOUN B-O
were AUX B-O
unchanged ADJ B-O
upon SCONJ B-O
activation NOUN B-O
of ADP B-O
canonical ADJ B-O
Wnt NOUN B-O
signaling NOUN B-O
in ADP B-O
the DET B-O
FSP1 PROPN B-AC
+ NOUN B-O
fibroblasts NOUN B-O
( PUNCT B-O
Fig NUM B-O
6C NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
matrix NOUN B-LF
metalloproteinase NOUN I-LF
( PUNCT B-O
MMP PROPN B-AC
) PUNCT B-O
family NOUN B-O
is AUX B-O
primarily ADV B-O
responsible ADJ B-O
for ADP B-O
the DET B-O
degradation NOUN B-O
and CCONJ B-O
remodeling NOUN B-O
of ADP B-O
extracellular ADJ B-O
matrix NOUN B-O
[ PUNCT B-O
6,21 NUM B-O
] PUNCT B-O
. PUNCT B-O

After ADP B-O
heat NOUN B-O
antigen NOUN B-O
retrieval NOUN B-O
using VERB B-O
sodium NOUN B-O
citrate NOUN B-O
buffer NOUN B-O
, PUNCT B-O
brain NOUN B-O
sections NOUN B-O
were AUX B-O
incubated VERB B-O
with ADP B-O
blocking VERB B-O
buffer NOUN B-O
( PUNCT B-O
10 NUM B-O
% NOUN B-O
Normal PROPN B-O
Goat PROPN B-O
Serum PROPN B-O
, PUNCT B-O
1 NUM B-O
% NOUN B-O
BSA PROPN B-O
, PUNCT B-O
and CCONJ B-O
3 NUM B-O
M NOUN B-O
Glycine PROPN B-O
in ADP B-O
TBS-0.1 NUM B-O
% NOUN B-O
Triton PROPN B-O
- PUNCT B-O
X PROPN B-O
) PUNCT B-O
for ADP B-O
1 NUM B-O
hour NOUN B-O
at ADP B-O
room NOUN B-LF
temperature NOUN I-LF
( PUNCT B-O
RT PROPN B-AC
) PUNCT B-O
. PUNCT B-O

After ADP B-O
blocking VERB B-O
, PUNCT B-O
antibodies NOUN B-O
were AUX B-O
diluted VERB B-O
in ADP B-O
blocking VERB B-O
buffer NOUN B-O
and CCONJ B-O
incubated VERB B-O
overnight ADV B-O
at ADP B-O
4 NUM B-O
° NOUN B-O
C NOUN B-O
. PUNCT B-O

Healthy ADJ B-LF
controls NOUN I-LF
( PUNCT B-O
HC PROPN B-AC
): PUNCT B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
59 NUM B-O
) PUNCT B-O
21 NUM B-O
adult NOUN B-O
healthy ADJ B-LF
controls NOUN I-LF
and CCONJ B-O
38 NUM B-O
children NOUN B-O
older ADJ B-O
than ADP B-O
4 NUM B-O
were AUX B-O
included VERB B-O
in ADP B-O
Study NOUN B-O
2 NUM B-O
. PUNCT B-O

Primaquine PROPN B-LF
( PUNCT B-O
PQ PROPN B-AC
) PUNCT B-O
has AUX B-O
been AUX B-O
used VERB B-O
for ADP B-O
over ADP B-O
65 NUM B-O
years NOUN B-O
and CCONJ B-O
is AUX B-O
currently ADV B-O
the DET B-O
only ADJ B-O
widely ADV B-O
available ADJ B-O
hypnozoitocidal ADJ B-O
drug NOUN B-O
for ADP B-O
P. PROPN B-O
vivax PROPN B-O
and CCONJ B-O
P. PROPN B-O
ovale PROPN B-O
. PUNCT B-O

A DET B-O
recent ADJ B-O
report NOUN B-O
suggests VERB B-O
that SCONJ B-O
SDF-1 PROPN B-O
promotes VERB B-O
epidermal ADJ B-LF
stem NOUN I-LF
cell NOUN I-LF
( PUNCT B-O
ESC PROPN B-AC
) PUNCT B-O
migration NOUN B-O
and CCONJ B-O
accelerates VERB B-O
wound NOUN B-O
healing NOUN B-O
in ADP B-O
vivo ADV B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

Extracted VERB B-O
peptides NOUN B-O
were AUX B-O
analysed VERB B-O
by ADP B-O
liquid NOUN B-LF
chromatography NOUN I-LF
– PUNCT I-LF
tandem NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT B-O
LC–MS/MS PROPN B-AC
) PUNCT B-O
with ADP B-O
the DET B-O
Orbitrap PROPN B-O
Fusion PROPN B-O
mass NOUN B-O
spectrometer NOUN B-O
and CCONJ B-O
nanoflow NOUN B-O
- PUNCT B-O
HPLC NOUN B-O
system NOUN B-O
U3000 PROPN B-O
( PUNCT B-O
Thermo PROPN B-O
Fisher PROPN B-O
Scientific PROPN B-O
, PUNCT B-O
UK PROPN B-O
) PUNCT B-O
[ PUNCT B-O
48,50 NUM B-O
] PUNCT B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
aimed VERB B-O
to PART B-O
assess VERB B-O
the DET B-O
comparability NOUN B-O
among ADP B-O
assays NOUN B-O
using VERB B-O
freshly ADV B-O
frozen VERB B-O
human ADJ B-O
sera NOUN B-O
and CCONJ B-O
external ADJ B-LF
quality NOUN I-LF
assessment NOUN I-LF
( PUNCT B-O
EQA PROPN B-AC
) PUNCT B-O
data NOUN B-O
in ADP B-O
China PROPN B-O
. PUNCT B-O

The DET B-O
“ PUNCT B-O
gold NOUN B-O
standard NOUN B-O
” PUNCT B-O
for ADP B-O
NACT PROPN B-AC
response NOUN B-O
was AUX B-O
the DET B-O
5 NUM B-O
- PUNCT B-O
years NOUN B-O
relapse NOUN B-LF
free ADJ I-LF
survival NOUN I-LF
( PUNCT B-O
RFS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
as SCONJ B-O
it PRON B-O
provides VERB B-O
a DET B-O
reasonable ADJ B-O
threshold NOUN B-O
to ADP B-O
capture VERB B-O
all DET B-O
relapses NOUN B-O
related VERB B-O
to ADP B-O
NACT PROPN B-AC
response NOUN B-O
[ PUNCT B-O
11 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
ATP PROPN B-LF
- PUNCT I-LF
binding VERB I-LF
cassette NOUN I-LF
transporter NOUN I-LF
A1 NOUN I-LF
( PUNCT B-O
ABCA1 PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
cholesterol NOUN B-O
and CCONJ B-O
phospholipid NOUN B-O
transporter NOUN B-O
, PUNCT B-O
and CCONJ B-O
mutations NOUN B-O
in ADP B-O
ABCA1 PROPN B-AC
cause VERB B-O
Tangier PROPN B-LF
disease NOUN I-LF
( PUNCT B-O
TD PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1–3 NUM B-O
] PUNCT B-O
, PUNCT B-O
a DET B-O
rare ADJ B-O
disorder NOUN B-O
characterized VERB B-O
by ADP B-O
reduced VERB B-O
levels NOUN B-O
of ADP B-O
plasma NOUN B-O
high ADJ B-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT B-O
HDL PROPN B-AC
) PUNCT B-O
cholesterol NOUN B-O
and CCONJ B-O
increased VERB B-O
risk NOUN B-O
for ADP B-O
coronary ADJ B-O
artery NOUN B-O
disease NOUN B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
neonatal ADJ B-LF
mortality NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
NMR PROPN B-AC
) PUNCT B-O
has AUX B-O
declined VERB B-O
markedly ADV B-O
in ADP B-O
recent ADJ B-O
years NOUN B-O
in ADP B-O
Tanzania PROPN B-O
but CCONJ B-O
varies VERB B-O
widely ADV B-O
across ADP B-O
the DET B-O
country NOUN B-O
. PUNCT B-O

HSV-2 PROPN B-AC
, PUNCT B-O
herpes NOUN B-LF
simplex NOUN I-LF
virus NOUN I-LF
type NOUN I-LF
2 NUM I-LF
; PUNCT B-O
STI PROPN B-AC
, PUNCT B-O
sexually ADV B-LF
transmitted VERB I-LF
infection NOUN I-LF
. PUNCT B-O

Eight NUM B-O
databases NOUN B-O
, PUNCT B-O
PubMed PROPN B-O
, PUNCT B-O
GWAS PROPN B-AC
, PUNCT B-O
Embase PROPN B-O
, PUNCT B-O
Lochrane PROPN B-O
, PUNCT B-O
Ebsco PROPN B-O
, PUNCT B-O
CNKI PROPN B-AC
( PUNCT B-O
Chinese PROPN B-LF
National PROPN I-LF
Knowledge PROPN I-LF
Infrastructure PROPN I-LF
) PUNCT B-O
, PUNCT B-O
VIP PROPN B-AC
( PUNCT B-O
Viper PROPN B-LF
Database PROPN I-LF
) PUNCT B-O
and CCONJ B-O
ChinaInfo PROPN B-O
were AUX B-O
searched VERB B-O
, PUNCT B-O
and CCONJ B-O
a DET B-O
meta NOUN B-O
- NOUN B-O
analysis NOUN B-O
of ADP B-O
susceptibility NOUN B-O
was AUX B-O
conducted VERB B-O
between ADP B-O
SNP45 NOUN B-O
, PUNCT B-O
SNP276 NOUN B-O
polymorphisms NOUN B-O
and CCONJ B-O
T2DM PROPN B-AC
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
HWE PROPN B-AC
test NOUN B-O
was AUX B-O
conducted VERB B-O
to PART B-O
assess VERB B-O
the DET B-O
genetic ADJ B-O
balance NOUN B-O
of ADP B-O
the DET B-O
study NOUN B-O
, PUNCT B-O
evaluate VERB B-O
the DET B-O
quality NOUN B-O
of ADP B-O
Newcastle PROPN B-LF
– PUNCT I-LF
Ottawa PROPN I-LF
quality NOUN I-LF
assessment NOUN I-LF
scale NOUN I-LF
( PUNCT B-O
NOS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
establishing VERB B-O
allelic ADJ B-O
, PUNCT B-O
dominant ADJ B-O
, PUNCT B-O
recessive ADJ B-O
, PUNCT B-O
heterozygous ADJ B-O
, PUNCT B-O
and CCONJ B-O
homozygous ADJ B-O
gene NOUN B-O
models NOUN B-O
. PUNCT B-O

The DET B-O
carbohydrate NOUN B-O
composition NOUN B-O
of ADP B-O
the DET B-O
extracts NOUN B-O
was AUX B-O
analysed VERB B-O
using VERB B-O
polysaccharide NOUN B-LF
analysis NOUN I-LF
by ADP I-LF
carbohydrate NOUN I-LF
gel NOUN I-LF
electrophoresis NOUN I-LF
( PUNCT B-O
PACE PROPN B-AC
) PUNCT B-O
and CCONJ B-O
high ADJ B-O
- NOUN B-O
performance NOUN B-O
anion NOUN B-O
- NOUN B-O
exchange NOUN B-O
chromatography NOUN B-O
( PUNCT B-O
HPAEC PROPN B-O
) PUNCT B-O
. PUNCT B-O

Whether SCONJ B-O
there PRON B-O
were VERB B-O
any DET B-O
proteinaceous ADJ B-O
moieties NOUN B-O
linked VERB B-O
to ADP B-O
β PUNCT B-O
- NOUN B-O
glucan NOUN B-O
was AUX B-O
also ADV B-O
examined VERB B-O
. PUNCT B-O

Wild ADJ B-O
- PUNCT B-O
type NOUN B-O
( PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
Salmonella NOUN B-O
was AUX B-O
electroporated VERB B-O
with ADP B-O
6 NUM B-O
μM PROPN B-O
I NOUN B-O
- PUNCT B-O
switch NOUN B-O
and CCONJ B-O
recovered VERB B-O
in ADP B-O
SOC PROPN B-O
for ADP B-O
1 NUM B-O
h NOUN B-O
at ADP B-O
37 NUM B-O
° NOUN B-O
C NOUN B-O
, PUNCT B-O
followed VERB B-O
by ADP B-O
three NUM B-O
washes NOUN B-O
with ADP B-O
PBS PROPN B-O
. PUNCT B-O

Bacteria NOUN B-O
were AUX B-O
then ADV B-O
clamped VERB B-O
at ADP B-O
various ADJ B-O
pH NOUN B-O
values NOUN B-O
in ADP B-O
K+-rich NOUN B-O
buffer NOUN B-O
containing VERB B-O
40 NUM B-O
μM PROPN B-O
nigericin NOUN B-O
for ADP B-O
1 NUM B-O
h NOUN B-O
at ADP B-O
room NOUN B-LF
temperature NOUN I-LF
( PUNCT B-O
RT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
imaged VERB B-O
on ADP B-O
an DET B-O
Applied PROPN B-O
Precision PROPN B-O
Delta PROPN B-O
Vision PROPN B-O
inverted VERB B-O
wide ADJ B-O
- PUNCT B-O
field NOUN B-O
fluorescence NOUN B-O
microscope NOUN B-O
. PUNCT B-O

Protein NOUN B-O
export NOUN B-O
via ADP B-O
both DET B-O
fT3SS PROPN B-AC
and CCONJ B-O
vT3SS PROPN B-AC
is AUX B-O
primarily ADV B-O
dependent ADJ B-O
on ADP B-O
the DET B-O
proton NOUN B-LF
motive NOUN I-LF
force NOUN I-LF
( PUNCT B-O
pmf PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
5–9 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
CPM PROPN B-AC
, PUNCT B-O
counts NOUN B-LF
per ADP I-LF
minute NOUN I-LF
; PUNCT B-O
CRF PROPN B-AC
, PUNCT B-O
cardiorespiratory ADJ B-LF
fitness NOUN I-LF
; PUNCT B-O
CI PROPN B-O
, PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
. PUNCT B-O

The DET B-O
standard ADJ B-O
test NOUN B-O
for ADP B-O
infection NOUN B-O
is AUX B-O
the DET B-O
tuberculin NOUN B-LF
skin NOUN I-LF
test NOUN I-LF
( PUNCT B-O
TST PROPN B-AC
) PUNCT B-O
. PUNCT B-O

In ADP B-O
this PRON B-O
, PUNCT B-O
bacterial ADJ B-O
antigens NOUN B-O
( PUNCT B-O
proteins NOUN B-O
that PRON B-O
the DET B-O
immune ADJ B-O
system NOUN B-O
recognize VERB B-O
as ADP B-O
foreign ADJ B-O
) PUNCT B-O
are AUX B-O
injected VERB B-O
under ADP B-O
the DET B-O
skin NOUN B-O
. PUNCT B-O

No PROPN B-O
, PUNCT B-O
core NOUN B-O
number NOUN B-O
; PUNCT B-O
Dx NOUN B-O
, PUNCT B-O
diagnosis NOUN B-O
; PUNCT B-O
ILC PROPN B-AC
, PUNCT B-O
invasive ADJ B-LF
lobular ADJ I-LF
carcinoma NOUN I-LF
; PUNCT B-O
ITC PROPN B-AC
, PUNCT B-O
invasive ADJ B-LF
tubular ADJ I-LF
carcinoma NOUN I-LF
; PUNCT B-O
+ NUM B-O
, PUNCT B-O
positive ADJ B-O
; PUNCT B-O
EXP PROPN B-AC
, PUNCT B-O
expression NOUN B-LF
; PUNCT B-O
INTPN PROPN B-AC
, PUNCT B-O
interpretation NOUN B-LF
after ADP B-O
considering VERB B-O
the DET B-O
1 NUM B-O
+ NUM B-O
intensity NOUN B-O
( PUNCT B-O
2a NUM B-O
) PUNCT B-O
as ADP B-O
negative ADJ B-O
; PUNCT B-O
LC PROPN B-AC
, PUNCT B-O
lymphocyte NOUN B-LF
; PUNCT B-O
NS PROPN B-AC
, PUNCT B-O
no DET B-LF
lymphocytes NOUN B-LF
seen VERB I-LF
Ab PROPN B-AC
, PUNCT B-O
antibody NOUN B-LF
; PUNCT B-O
Iso PROPN B-O
, PUNCT B-O
Isotype PROPN B-O
control NOUN B-O
. PUNCT B-O

STAT3 PROPN B-AC
decoy NOUN B-O
was AUX B-O
loaded VERB B-O
on ADP B-O
cationic ADJ B-O
lipid NOUN B-O
microbubbles NOUN B-LF
( PUNCT B-O
STAT3 PROPN B-AC
) PUNCT B-O
or CCONJ B-O
loaded VERB B-O
on ADP B-O
liposome NOUN B-O
- PUNCT B-O
conjugated VERB B-O
lipid NOUN B-O
microbubbles NOUN B-LF
to PART B-O
form VERB B-O
-MBSTAT3 PROPN B-AC
- PUNCT B-O
loaded VERB B-O
liposome NOUN B-O
- PUNCT B-O
microbubble NOUN B-LF
complexes NOUN B-O
( PUNCT B-O
STAT3 PROPN B-AC
) PUNCT B-O
. PUNCT B-O

-LPXUTMC PROPN B-AC
treatment NOUN B-O
efficacy NOUN B-O
with ADP B-O
these DET B-O
two NUM B-O
formulations NOUN B-O
was AUX B-O
evaluated VERB B-O
in ADP B-O
vitro ADV B-O
using VERB B-O
viability NOUN B-O
and CCONJ B-O
apoptosis NOUN B-O
assays NOUN B-O
in ADP B-O
CAL33 PROPN B-O
( PUNCT B-O
human ADJ B-O
HNSCC PROPN B-AC
) PUNCT B-O
cells NOUN B-O
. PUNCT B-O

BF PROPN B-O
, PUNCT B-O
Burkina PROPN B-O
Faso PROPN B-O
; PUNCT B-O
DRC PROPN B-AC
, PUNCT B-O
Democratic PROPN B-LF
Republic PROPN I-LF
of ADP I-LF
the DET I-LF
Congo PROPN I-LF
; PUNCT B-O
EMEP PROPN B-O
, PUNCT B-O
Evaluation NOUN B-O
of ADP B-O
Medications NOUN B-O
used VERB B-O
in ADP B-O
Early PROPN B-O
Pregnancy NOUN B-O
; PUNCT B-O
GA PROPN B-O
, PUNCT B-O
gestational ADJ B-O
age NOUN B-O
; PUNCT B-O
IPTp PROPN B-AC
, PUNCT B-O
intermittent ADJ B-LF
preventive ADJ I-LF
treatment NOUN I-LF
in ADP I-LF
pregnancy NOUN I-LF
; PUNCT B-O
ITN PROPN B-O
, PUNCT B-O
insecticide NOUN B-O
- PUNCT B-O
treated VERB B-O
bed NOUN B-O
nets NOUN B-O
; PUNCT B-O
M3 PROPN B-AC
, PUNCT B-O
Maternal PROPN B-LF
Malaria NOUN I-LF
and CCONJ I-LF
Malnutrition PROPN I-LF
; PUNCT B-O
PNG PROPN B-AC
, PUNCT B-O
Papua PROPN B-LF
New PROPN I-LF
Guinea PROPN I-LF
; PUNCT B-O
STOPPAM PROPN B-O
, PUNCT B-O
Strategies NOUN B-O
to PART B-O
Prevent VERB B-O
Pregnancy NOUN B-O
- PUNCT B-O
Associated VERB B-O
Malaria NOUN B-O
. PUNCT B-O

The DET B-O
prognostic ADJ B-O
values NOUN B-O
of ADP B-O
left ADJ B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
( PUNCT B-O
LVEF PROPN B-AC
) PUNCT B-O
during ADP B-O
heart NOUN B-LF
failure NOUN I-LF
( PUNCT B-O
HF PROPN B-AC
) PUNCT B-O
with ADP B-O
acute ADJ B-O
decompensation NOUN B-O
or CCONJ B-O
after ADP B-O
optimal ADJ B-O
treatment NOUN B-O
have AUX B-O
not PART B-O
been AUX B-O
extensively ADV B-O
studied VERB B-O
. PUNCT B-O

( PUNCT B-O
Photo- ADJ B-O
) PUNCT B-O
chemical ADJ B-O
cross ADJ B-O
- ADJ B-O
linking ADJ B-O
combined VERB B-O
with ADP B-O
mass NOUN B-LF
spectrometry NOUN I-LF
( PUNCT B-O
MS PROPN B-AC
) PUNCT B-O
has AUX B-O
evolved VERB B-O
as ADP B-O
an DET B-O
alternative ADJ B-O
method NOUN B-O
to PART B-O
obtain VERB B-O
low ADJ B-O
- ADJ B-O
resolution NOUN B-O
three NUM B-O
- ADJ B-O
dimensional ADJ B-O
( PUNCT B-O
3D ADJ B-O
) PUNCT B-O
structural ADJ B-O
information NOUN B-O
of ADP B-O
proteins NOUN B-O
and CCONJ B-O
protein NOUN B-O
complexes.[1–9 NUM B-O
] PUNCT B-O
The DET B-O
cross ADJ B-O
- ADJ B-O
linking ADJ B-O
/ SYM B-O
MS PROPN B-AC
approach NOUN B-O
allows VERB B-O
deriving VERB B-O
structural ADJ B-O
information NOUN B-O
by ADP B-O
covalently ADV B-O
connecting VERB B-O
pairs NOUN B-O
of ADP B-O
functional ADJ B-O
groups NOUN B-O
in ADP B-O
the DET B-O
protein(s NOUN B-O
) PUNCT B-O
under ADP B-O
investigation NOUN B-O
. PUNCT B-O

The DET B-O
widespread ADJ B-O
presence NOUN B-O
of ADP B-O
overweight NOUN B-O
and CCONJ B-O
obesity NOUN B-O
increases VERB B-O
with ADP B-O
every DET B-O
decade NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
number NOUN B-O
of ADP B-O
people NOUN B-O
with ADP B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
> ADP B-O
30 NUM B-O
kg NOUN B-O
/ SYM B-O
m2 NOUN B-O
has AUX B-O
doubled VERB B-O
in ADP B-O
the DET B-O
last ADJ B-O
30 NUM B-O
years NOUN B-O
. PUNCT B-O

Effect NOUN B-O
of ADP B-O
mitoCCCP PROPN B-AC
and CCONJ B-O
CCCP PROPN B-AC
on ADP B-O
the DET B-O
pH NOUN B-O
gradient NOUN B-O
across ADP B-O
the DET B-O
membranes NOUN B-O
of ADP B-O
submitochondrial ADJ B-LF
particles NOUN I-LF
( PUNCT B-O
SMP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
as SCONJ B-O
measured VERB B-O
by ADP B-O
ACMA PROPN B-AC
( PUNCT B-O
0.5 NUM B-O
μg NOUN B-O
/ SYM B-O
ml NOUN B-O
) PUNCT B-O
fluorescence NOUN B-O
. PUNCT B-O

Within ADP B-O
the DET B-O
DOT PROPN B-AC
- PUNCT B-O
group NOUN B-O
, PUNCT B-O
SVR12 PROPN B-O
was AUX B-O
achieved VERB B-O
in ADP B-O
99.1 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
: PUNCT B-O
95.0–100 NUM B-O
; PUNCT B-O
n NOUN B-O
= SYM B-O
109/110 NUM B-O
) PUNCT B-O
with ADP B-O
one NUM B-O
patient NOUN B-O
experiencing VERB B-O
treatment NOUN B-O
failure NOUN B-O
, PUNCT B-O
while SCONJ B-O
n NOUN B-O
= SYM B-O
12/122 NUM B-O
( PUNCT B-O
9.8 NUM B-O
% NOUN B-O
) PUNCT B-O
patients NOUN B-O
were AUX B-O
excluded VERB B-O
due ADP B-O
to ADP B-O
loss NOUN B-O
of ADP B-O
follow NOUN B-LF
- PUNCT I-LF
up NOUN I-LF
( PUNCT B-O
FU PROPN B-AC
) PUNCT B-O
. PUNCT B-O

5 NUM B-O
patients NOUN B-O
showed VERB B-O
HCV PROPN B-AC
reinfection NOUN B-O
after ADP B-O
achieving VERB B-O
SVR12 PROPN B-O
. PUNCT B-O

We PRON B-O
assumed VERB B-O
that PRON B-O
lung NOUN B-O
tissues NOUN B-O
are AUX B-O
protected VERB B-O
from ADP B-O
overactive ADJ B-O
immune ADJ B-O
cells NOUN B-O
by ADP B-O
the DET B-O
same ADJ B-O
hypoxia NOUN B-O
- PUNCT B-O
driven VERB B-O
mechanism NOUN B-O
and CCONJ B-O
immunosuppressive ADJ B-O
adenosine NOUN B-LF
A2A NOUN I-LF
receptor NOUN I-LF
( PUNCT B-O
A2AR)-mediated PROPN B-AC
mechanism NOUN B-O
that PRON B-O
was AUX B-O
recently ADV B-O
shown VERB B-O
to PART B-O
play VERB B-O
a DET B-O
critical ADJ B-O
role NOUN B-O
in ADP B-O
the DET B-O
down NOUN B-O
- PUNCT B-O
regulation NOUN B-O
of ADP B-O
inflammation NOUN B-O
and CCONJ B-O
tissue NOUN B-O
damage NOUN B-O
in ADP B-O
different ADJ B-O
models NOUN B-O
[ PUNCT B-O
4–7 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
FDR PROPN B-AC
) PUNCT B-O
was AUX B-O
controlled VERB B-O
by ADP B-O
adjusting VERB B-O
the DET B-O
p NOUN B-O
value NOUN B-O
using VERB B-O
the DET B-O
Benjamini PROPN B-O
- PUNCT B-O
Hochberg PROPN B-O
algorithm NOUN B-O
. PUNCT B-O

We PRON B-O
used VERB B-O
the DET B-O
three NUM B-O
Ethiopian ADJ B-LF
demographic ADJ I-LF
and CCONJ I-LF
health NOUN I-LF
surveys NOUN I-LF
( PUNCT B-O
EDHSs PROPN B-AC
) PUNCT B-O
( PUNCT B-O
2005 NUM B-O
, PUNCT B-O
2011 NUM B-O
, PUNCT B-O
and CCONJ B-O
2016 NUM B-O
) PUNCT B-O
data NOUN B-O
, PUNCT B-O
which PRON B-O
are AUX B-O
the DET B-O
nationally ADV B-O
representative ADJ B-O
surveys NOUN B-O
performed VERB B-O
in ADP B-O
Ethiopia PROPN B-O
. PUNCT B-O

Acquiring VERB B-O
and CCONJ B-O
sharing VERB B-O
large ADJ B-O
amounts NOUN B-O
of ADP B-O
neuroimaging NOUN B-O
data NOUN B-O
have AUX B-O
recently ADV B-O
become VERB B-O
critical ADJ B-O
for ADP B-O
bridging VERB B-O
the DET B-O
gap NOUN B-O
between ADP B-O
basic ADJ B-O
neuroscience NOUN B-O
research NOUN B-O
and CCONJ B-O
clinical ADJ B-O
applications NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
the DET B-O
diagnosis NOUN B-O
and CCONJ B-O
treatment NOUN B-O
of ADP B-O
psychiatric ADJ B-O
disorders NOUN B-O
( PUNCT B-O
Human PROPN B-LF
Connectome PROPN I-LF
Project PROPN I-LF
[ PUNCT B-O
HCP PROPN B-AC
] PUNCT B-O
[ PUNCT B-O
1 X B-O
] PUNCT B-O
[ PUNCT B-O
http://www.humanconnectomeproject.org/ X B-O
] PUNCT B-O
; PUNCT B-O
Human PROPN B-O
Brain PROPN B-O
Project PROPN B-O
[ PUNCT B-O
https://www.humanbrainproject.eu/en/ X B-O
] PUNCT B-O
; PUNCT B-O
UK PROPN B-O
Biobank PROPN B-O
[ PUNCT B-O
http://www.ukbiobank.ac.uk/ X B-O
] PUNCT B-O
; PUNCT B-O
and CCONJ B-O
Strategic PROPN B-LF
Research PROPN I-LF
Program PROPN I-LF
for ADP I-LF
Brain PROPN I-LF
Sciences PROPN I-LF
[ PUNCT B-O
SRPBS PROPN B-AC
] PUNCT B-O
[ PUNCT B-O
2 X B-O
] PUNCT B-O
[ PUNCT B-O
https://bicr.atr.jp/decnefpro/ X B-O
] PUNCT B-O
) PUNCT B-O
[ PUNCT B-O
3–5 NUM B-O
] PUNCT B-O
. PUNCT B-O

Analysis NOUN B-O
of ADP B-O
the DET B-O
molecular ADJ B-LF
dynamics NOUN I-LF
( PUNCT B-O
MD PROPN B-AC
) PUNCT B-O
trajectories NOUN B-O
and CCONJ B-O
binding VERB B-O
free ADJ B-O
energy NOUN B-O
components NOUN B-O
shed VERB B-O
light NOUN B-O
into ADP B-O
understanding VERB B-O
the DET B-O
mechanism NOUN B-O
of ADP B-O
the DET B-O
binding VERB B-O
specificity NOUN B-O
of ADP B-O
the DET B-O
Abl PROPN B-O
SH3 PROPN B-AC
domain NOUN B-O
. PUNCT B-O

HCVcc PROPN B-AC
was AUX B-O
produced VERB B-O
and CCONJ B-O
50 NUM B-LF
% NOUN I-LF
tissue NOUN I-LF
culture NOUN I-LF
infective ADJ I-LF
dose NOUN I-LF
( PUNCT B-O
TCID50 PROPN B-AC
) PUNCT B-O
determined VERB B-O
as SCONJ B-O
described VERB B-O
[ PUNCT B-O
37 NUM B-O
] PUNCT B-O
. PUNCT B-O

Data NOUN B-O
are AUX B-O
presented VERB B-O
with ADP B-O
counts NOUN B-O
unless SCONJ B-O
otherwise ADV B-O
stated VERB B-O
. PUNCT B-O

95%CI PROPN B-AC
: PUNCT B-O
95 NUM B-LF
% NOUN I-LF
confidence NOUN I-LF
interval NOUN I-LF
; PUNCT B-O
BSI PROPN B-AC
: PUNCT B-O
Bronchiectasis PROPN B-LF
Severity PROPN I-LF
Index PROPN I-LF
. PUNCT B-O

To PART B-O
separate VERB B-O
the DET B-O
active ADJ B-O
compounds NOUN B-O
, PUNCT B-O
preparative ADJ B-LF
high ADJ I-LF
performance NOUN I-LF
liquid NOUN I-LF
chromatography NOUN I-LF
( PUNCT B-O
PHPLC PROPN B-AC
) PUNCT B-O
was AUX B-O
conducted VERB B-O
on ADP B-O
a DET B-O
Waters PROPN B-O
2545 NUM B-O
series NOUN B-O
instrument NOUN B-O
( PUNCT B-O
Waters PROPN B-O
, PUNCT B-O
USA PROPN B-O
) PUNCT B-O
equipped VERB B-O
with ADP B-O
a DET B-O
OBD PROPN B-O
- PUNCT B-O
C18 NUM B-O
column NOUN B-O
( PUNCT B-O
19 NUM B-O
mm NOUN B-O
×150 NUM B-O
mm NOUN B-O
, PUNCT B-O
10 NUM B-O
μm NOUN B-O
, PUNCT B-O
Waters PROPN B-O
, PUNCT B-O
USA PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
mobile ADJ B-O
phase NOUN B-O
used VERB B-O
for ADP B-O
PHPLC PROPN B-AC
was AUX B-O
methanol NOUN B-O
/ SYM B-O
H2O NOUN B-O
( PUNCT B-O
1:4 NOUN B-O
, PUNCT B-O
v NOUN B-O
/ SYM B-O
v NOUN B-O
) PUNCT B-O
, PUNCT B-O
applied VERB B-O
with ADP B-O
a DET B-O
flow NOUN B-O
rate NOUN B-O
of ADP B-O
8 NUM B-O
mL NOUN B-O
/ SYM B-O
min NOUN B-O
, PUNCT B-O
and CCONJ B-O
ultraviolet ADJ B-O
detection NOUN B-O
was AUX B-O
a DET B-O
210 NUM B-O
nm NOUN B-O
. PUNCT B-O

Enhanced VERB B-O
mean ADJ B-O
intensity NOUN B-O
images NOUN B-O
are AUX B-O
shown VERB B-O
to ADP B-O
demonstrate VERB B-O
the DET B-O
alignment NOUN B-O
procedure NOUN B-O
between ADP B-O
a DET B-O
recording NOUN B-O
in ADP B-O
Iso PROPN B-AC
( PUNCT B-O
A NOUN B-O
) PUNCT B-O
and CCONJ B-O
one NUM B-O
during ADP B-O
wakefulness NOUN B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
C NOUN B-O
) PUNCT B-O
Mean ADJ B-O
intensity NOUN B-O
image NOUN B-O
of ADP B-O
the DET B-O
awake ADJ B-O
recording NOUN B-O
aligned VERB B-O
to ADP B-O
the DET B-O
anesthesia NOUN B-O
condition NOUN B-O
. PUNCT B-O

( PUNCT B-O
D NOUN B-O
) PUNCT B-O
Overlaid VERB B-O
, PUNCT B-O
enhanced VERB B-O
mean ADJ B-O
intensity NOUN B-O
images NOUN B-O
before ADP B-O
and CCONJ B-O
after SCONJ B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
the DET B-O
alignment NOUN B-O
algorithm NOUN B-O
was AUX B-O
applied VERB B-O
. PUNCT B-O

( PUNCT B-O
F NOUN B-O
) PUNCT B-O
ROIs PROPN B-AC
of ADP B-O
active ADJ B-O
neurons NOUN B-O
during ADP B-O
wakefulness NOUN B-O
( PUNCT B-O
pink NOUN B-O
) PUNCT B-O
, PUNCT B-O
Iso PROPN B-AC
anesthesia NOUN B-O
( PUNCT B-O
cyan NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
their PRON B-O
overlap NOUN B-O
( PUNCT B-O
black NOUN B-O
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
G NOUN B-O
– PUNCT B-O
I NOUN B-O
) PUNCT B-O
Magnified VERB B-O
views NOUN B-O
of ADP B-O
a DET B-O
randomly ADV B-O
selected VERB B-O
sections NOUN B-O
from ADP B-O
panels NOUN B-O
( PUNCT B-O
D)–(F NOUN B-O
) PUNCT B-O
. PUNCT B-O

Iso PROPN B-AC
, PUNCT B-O
isoflurane NOUN B-LF
; PUNCT B-O
ROI PROPN B-AC
, PUNCT B-O
region NOUN B-LF
of ADP I-LF
interest NOUN I-LF
. PUNCT B-O

For ADP B-O
example NOUN B-O
, PUNCT B-O
the DET B-O
depletion NOUN B-O
of ADP B-O
CpG NOUN B-O
dinucleotides NOUN B-O
in ADP B-O
vertebrate NOUN B-O
- PUNCT B-O
infecting VERB B-O
RNA NOUN B-O
virus NOUN B-O
genomes NOUN B-O
may AUX B-O
have AUX B-O
arisen VERB B-O
to PART B-O
evade VERB B-O
zinc NOUN B-LF
- PUNCT I-LF
finger NOUN I-LF
antiviral ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
ZAP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
an DET B-O
interferon NOUN B-LF
- PUNCT I-LF
stimulated VERB I-LF
gene NOUN I-LF
( PUNCT B-O
ISG PROPN B-AC
) PUNCT B-O
that PRON B-O
initiates VERB B-O
the DET B-O
degradation NOUN B-O
of ADP B-O
CpG NOUN B-O
- PUNCT B-O
rich ADJ B-O
RNA NOUN B-O
molecules NOUN B-O
[ PUNCT B-O
12 NUM B-O
] PUNCT B-O
. PUNCT B-O

All DET B-O
participants NOUN B-O
in ADP B-O
the DET B-O
training NOUN B-O
program NOUN B-O
were AUX B-O
key ADJ B-O
persons NOUN B-O
, PUNCT B-O
recruited VERB B-O
among ADP B-O
93 NUM B-O
eligible ADJ B-O
baggage NOUN B-O
handlers NOUN B-O
identified VERB B-O
to ADP B-O
have VERB B-O
key ADJ B-O
roles NOUN B-O
in ADP B-O
the DET B-O
company NOUN B-O
( PUNCT B-O
Table NOUN B-O
1 NUM B-O
) PUNCT B-O
, PUNCT B-O
i.e. X B-O
safety NOUN B-LF
officers NOUN I-LF
( PUNCT B-O
SO PROPN B-AC
) PUNCT B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
16 NUM B-O
) PUNCT B-O
, PUNCT B-O
instructors NOUN B-O
teaching VERB B-O
the DET B-O
use NOUN B-O
of ADP B-O
technical ADJ B-O
devices NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
26 NUM B-O
) PUNCT B-O
, PUNCT B-O
coordinators NOUN B-O
allocating VERB B-O
tasks NOUN B-O
to ADP B-O
baggage NOUN B-O
handlers NOUN B-O
during ADP B-O
the DET B-O
shift NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
42 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
managers NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
9 NUM B-O
) PUNCT B-O
. PUNCT B-O

ChIP PROPN B-O
, PUNCT B-O
chromatin NOUN B-O
immunoprecipitation NOUN B-O
; PUNCT B-O
CREB PROPN B-AC
, PUNCT B-O
cAMP NOUN B-LF
responsive ADJ I-LF
element NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT B-O
DHS PROPN B-AC
, PUNCT B-O
DNase NOUN B-LF
hypersensitive ADJ I-LF
site NOUN I-LF
; PUNCT B-O
FDR PROPN B-AC
, PUNCT B-O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
; PUNCT B-O
FOXO1 PROPN B-AC
, PUNCT B-O
Forkhead PROPN B-LF
box NOUN I-LF
O1 NOUN I-LF
; PUNCT B-O
GR PROPN B-AC
, PUNCT B-O
glucocorticoid NOUN B-LF
receptor NOUN I-LF
; PUNCT B-O
H3K27Ac PROPN B-O
, PUNCT B-O
Histone NOUN B-O
3 NUM B-O
lysine NOUN B-O
27 NUM B-O
acetylation NOUN B-O
; PUNCT B-O
ROC PROPN B-AC
, PUNCT B-O
receiver NOUN B-LF
operating NOUN I-LF
characteristic NOUN I-LF
; PUNCT B-O
TSS PROPN B-AC
, PUNCT B-O
transcription NOUN B-LF
start NOUN I-LF
site NOUN I-LF
. PUNCT B-O

In ADP B-O
the DET B-O
Mexican ADJ B-O
cohort NOUN B-O
, PUNCT B-O
the DET B-O
fibrotic ADJ B-O
non ADJ B-O
- NOUN B-O
IPF PROPN B-AC
group NOUN B-O
consisted VERB B-O
of ADP B-O
patients NOUN B-O
with ADP B-O
Rheumatoid PROPN B-LF
Arthritis PROPN I-LF
interstitial ADJ B-LF
lung NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
RA PROPN B-AC
-ILD PROPN B-AC
n NOUN B-O
= SYM B-O
18 NUM B-O
) PUNCT B-O
, PUNCT B-O
Sjögren PROPN B-O
Syndrome PROPN B-O
interstitial ADJ B-LF
lung NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
SS NOUN B-O
- NOUN B-O
ILD PROPN B-AC
n NOUN B-O
= SYM B-O
5 NUM B-O
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
chronic ADJ B-LF
hypersensitivity ADJ I-LF
pneumonitis NOUN I-LF
( PUNCT B-O
cHP PROPN B-AC
n NOUN B-O
= SYM B-O
46 NUM B-O
) PUNCT B-O
. PUNCT B-O

BChl PROPN B-AC
, PUNCT B-O
bacteriochlorophyll NOUN B-LF
; PUNCT B-O
CD PROPN B-AC
, PUNCT B-O
circular ADJ B-LF
dichroism NOUN I-LF
; PUNCT B-O
LD PROPN B-AC
, PUNCT B-O
linear ADJ B-LF
dichroism NOUN I-LF
; PUNCT B-O
LH1 PROPN B-AC
, PUNCT B-O
light NOUN B-LF
- PUNCT I-LF
harvesting NOUN I-LF
complex NOUN I-LF
1 NUM I-LF
; PUNCT B-O
mdeg NOUN B-O
, PUNCT B-O
millidegree NOUN B-O
; PUNCT B-O
NIR PROPN B-AC
, PUNCT B-O
near ADJ B-LF
infrared ADJ I-LF
region NOUN I-LF
; PUNCT B-O
rel NOUN B-O
. PUNCT B-O

u. PROPN B-O
, PUNCT B-O
relative ADJ B-O
units NOUN B-O
. PUNCT B-O

MPoRT PROPN B-AC
parameters NOUN B-O
, PUNCT B-O
including VERB B-O
variable ADJ B-O
description NOUN B-O
, PUNCT B-O
derivation NOUN B-O
and CCONJ B-O
calibration NOUN B-O
are AUX B-O
available ADJ B-O
as ADP B-O
Predictive PROPN B-LF
Modelling PROPN I-LF
Markup PROPN I-LF
Language NOUN I-LF
( PUNCT B-O
PMML PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Lime PROPN B-O
questionnaire NOUN B-O
files NOUN B-O
( PUNCT B-O
See VERB B-O
: PUNCT B-O
S2 PROPN B-O
Text PROPN B-O
, PUNCT B-O
S3 PROPN B-O
Text PROPN B-O
, PUNCT B-O
https://github.com/Ottawa-mHealth/predictive-algorithms X B-O
) PUNCT B-O
[ PUNCT B-O
41,42 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
components NOUN B-O
related VERB B-O
to ADP B-O
blood NOUN B-LF
pressure NOUN I-LF
and CCONJ B-O
the DET B-O
metabolism NOUN B-O
of ADP B-O
glucose NOUN B-O
— PUNCT B-O
high ADJ B-O
- PUNCT B-O
normal ADJ B-O
BP PROPN B-AC
, PUNCT B-O
DM2 PROPN B-AC
, PUNCT B-O
hypertension NOUN B-O
and CCONJ B-O
impaired ADJ B-O
fasting VERB B-O
glucose NOUN B-O
— PUNCT B-O
were AUX B-O
, PUNCT B-O
in ADP B-O
this DET B-O
order NOUN B-O
, PUNCT B-O
those PRON B-O
that PRON B-O
, PUNCT B-O
when SCONJ B-O
they PRON B-O
appear VERB B-O
first ADV B-O
, PUNCT B-O
determine VERB B-O
having VERB B-O
a DET B-O
first ADV B-O
episode NOUN B-O
of ADP B-O
MS PROPN B-AC
, PUNCT B-O
whereas SCONJ B-O
the DET B-O
components NOUN B-O
related VERB B-O
to ADP B-O
dyslipidaemia NOUN B-O
were AUX B-O
associated VERB B-O
with ADP B-O
a DET B-O
lower ADJ B-O
risk NOUN B-O
when SCONJ B-O
they PRON B-O
appear VERB B-O
first ADV B-O
. PUNCT B-O

SIS PROPN B-AC
- PUNCT B-O
ECM PROPN B-AC
; PUNCT B-O
Small ADJ B-LF
intestinal ADJ I-LF
submucosa NOUN I-LF
- PUNCT B-O
extra ADJ B-LF
cellular ADJ I-LF
matrix NOUN I-LF
, PUNCT B-O
TE PROPN B-AC
; PUNCT B-O
Tissue NOUN B-LF
engineering NOUN I-LF
. PUNCT B-O

Among ADP B-O
women NOUN B-O
, PUNCT B-O
food NOUN B-O
insufficiency NOUN B-O
was AUX B-O
associated VERB B-O
with ADP B-O
approximately ADV B-O
70 NUM B-O
% NOUN B-O
higher ADJ B-O
odds NOUN B-O
of ADP B-O
inconsistent ADJ B-O
condom NOUN B-O
use NOUN B-O
with ADP B-O
a DET B-O
nonprimary ADJ B-O
partner NOUN B-O
after ADP B-O
adjusting VERB B-O
for ADP B-O
other ADJ B-O
covariates NOUN B-O
in ADP B-O
a DET B-O
multivariate ADJ B-O
model NOUN B-O
( PUNCT B-O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
[ X B-O
AOR PROPN B-AC
] X B-O
1.73 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
[ X B-O
CI PROPN B-AC
] X B-O
1.27–2.36 NUM B-O
) PUNCT B-O
( PUNCT B-O
Table PROPN B-O
2 NUM B-O
) PUNCT B-O
. PUNCT B-O

ASA PROPN B-AC
, PUNCT B-O
American PROPN B-LF
Society PROPN I-LF
of ADP I-LF
Anaesthesiologists PROPN I-LF
; PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
OKS PROPN B-AC
, PUNCT B-O
Oxford PROPN B-LF
Knee PROPN I-LF
Score PROPN I-LF
; PUNCT B-O
TKR PROPN B-AC
, PUNCT B-O
total ADJ B-LF
knee NOUN I-LF
replacement NOUN I-LF
. PUNCT B-O

Manuscript NOUN B-O
, PUNCT B-O
page NOUN B-O
5 NUM B-O
, PUNCT B-O
line NOUN B-O
70 NUM B-O
- PUNCT B-O
76 NUM B-O
: PUNCT B-O
In ADP B-O
our PRON B-O
previous ADJ B-O
work NOUN B-O
, PUNCT B-O
we PRON B-O
integrated VERB B-O
EBV NOUN B-LF
- PUNCT I-LF
EBV PROPN B-AC
encoded VERB I-LF
small ADJ I-LF
RNA NOUN I-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
( PUNCT B-O
EBER PROPN B-AC
) PUNCT B-O
, PUNCT B-O
immunohistochemistry NOUN B-O
of ADP B-O
DNA NOUN B-O
mismatch NOUN B-O
proteins NOUN B-O
( PUNCT B-O
-ISHMMR PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Lauren NOUN B-O
histotyping NOUN B-O
to ADP B-O
design VERB B-O
a DET B-O
practical ADJ B-O
-IHCGC PROPN B-AC
subtyping NOUN B-O
algorithm NOUN B-O
, PUNCT B-O
parallel ADJ B-O
to ADP B-O
the DET B-O
TCGA PROPN B-AC
classification NOUN B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
2002–2016 NUM B-O
Nationwide PROPN B-LF
Inpatient PROPN I-LF
Sample PROPN I-LF
( PUNCT B-O
NIS PROPN B-AC
) PUNCT B-O
was AUX B-O
analyzed VERB B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
have AUX B-O
performed VERB B-O
flat ADJ B-O
panel NOUN B-O
- PUNCT B-O
based VERB B-O
volume NOUN B-O
computed VERB B-O
tomography NOUN B-O
( PUNCT B-O
fpVCT PROPN B-AC
) PUNCT B-O
for ADP B-O
rapid ADJ B-O
high ADJ B-O
- PUNCT B-O
resolution NOUN B-O
imaging NOUN B-O
of ADP B-O
bone NOUN B-O
structures NOUN B-O
in ADP B-O
combination NOUN B-O
with ADP B-O
artificial ADJ B-LF
neuronal ADJ I-LF
networks NOUN I-LF
( PUNCT B-O
ANNs PROPN B-AC
) PUNCT B-O
that PRON B-O
are AUX B-O
complex ADJ B-O
nonlinear ADJ B-O
computational ADJ B-O
models NOUN B-O
, PUNCT B-O
designed VERB B-O
much ADV B-O
like ADP B-O
the DET B-O
neuronal ADJ B-O
organization NOUN B-O
of ADP B-O
a DET B-O
brain NOUN B-O
[ X B-O
10–15 NUM B-O
] PUNCT B-O
. PUNCT B-O

Physical ADJ B-O
exercise NOUN B-O
has VERB B-O
a DET B-O
neuromodulatory ADJ B-O
effect NOUN B-O
on ADP B-O
the DET B-O
central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
( PUNCT B-O
CNS PROPN B-AC
) PUNCT B-O
partially ADV B-O
by ADP B-O
modifying VERB B-O
expression NOUN B-O
of ADP B-O
neuropeptides NOUN B-O
produced VERB B-O
and CCONJ B-O
secreted VERB B-O
by ADP B-O
neurons NOUN B-O
and CCONJ B-O
glial ADJ B-O
cells NOUN B-O
, PUNCT B-O
among ADP B-O
which PRON B-O
the DET B-O
best ADV B-O
examined VERB B-O
are AUX B-O
brain NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
neurotrophic ADJ I-LF
factor NOUN I-LF
( PUNCT B-O
BDNF PROPN B-AC
) PUNCT B-O
and CCONJ B-O
glial ADJ B-LF
cell NOUN I-LF
line NOUN I-LF
- PUNCT I-LF
derived VERB I-LF
neurotrophic ADJ I-LF
factor NOUN I-LF
( PUNCT B-O
GDNF PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Because SCONJ B-O
both DET B-O
neurotrophins NOUN B-O
can AUX B-O
cross VERB B-O
the DET B-O
brain NOUN B-O
- PUNCT B-O
blood NOUN B-O
barrier NOUN B-O
( PUNCT B-O
BBB PROPN B-AC
) PUNCT B-O
, PUNCT B-O
their PRON B-O
blood NOUN B-O
levels NOUN B-O
indirectly ADV B-O
reflect VERB B-O
their PRON B-O
production NOUN B-O
in ADP B-O
the DET B-O
CNS PROPN B-AC
. PUNCT B-O

Moreover ADV B-O
, PUNCT B-O
both DET B-O
neuropeptides NOUN B-O
are AUX B-O
involved VERB B-O
in ADP B-O
modulation NOUN B-O
of ADP B-O
dopaminergic ADJ B-O
and CCONJ B-O
serotoninergic ADJ B-O
system NOUN B-O
function NOUN B-O
. PUNCT B-O

Trypsin NOUN B-O
- PUNCT B-O
EDTA PROPN B-O
( PUNCT B-O
0.05 NUM B-O
% NOUN B-O
) PUNCT B-O
was AUX B-O
prepared VERB B-O
by ADP B-O
diluting VERB B-O
trypsin NOUN B-O
- PUNCT B-O
EDTA PROPN B-O
( PUNCT B-O
0.5 NUM B-O
% NOUN B-O
) PUNCT B-O
in ADP B-O
phosphate NOUN B-LF
- PUNCT I-LF
buffered VERB I-LF
saline NOUN I-LF
( PUNCT B-O
PBS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

All DET B-O
cell NOUN B-O
culture NOUN B-O
materials NOUN B-O
were AUX B-O
obtained VERB B-O
from ADP B-O
Gibco PROPN B-O
( PUNCT B-O
Life PROPN B-O
Technologies PROPN B-O
, PUNCT B-O
Breda PROPN B-O
, PUNCT B-O
The DET B-O
Netherlands PROPN B-O
) PUNCT B-O
. PUNCT B-O

Despite SCONJ B-O
the DET B-O
significance NOUN B-O
of ADP B-O
insertions NOUN B-LF
and CCONJ I-LF
deletions NOUN I-LF
( PUNCT B-O
indels PROPN B-AC
) PUNCT B-O
for ADP B-O
human ADJ B-O
genetic ADJ B-O
disease NOUN B-O
[ PUNCT B-O
1 X B-O
] PUNCT B-O
and CCONJ B-O
genome NOUN B-O
evolution NOUN B-O
[ PUNCT B-O
2–5 NUM B-O
] PUNCT B-O
, PUNCT B-O
the DET B-O
mechanisms NOUN B-O
of ADP B-O
their PRON B-O
mutagenesis NOUN B-O
are AUX B-O
not PART B-O
completely ADV B-O
understood VERB B-O
. PUNCT B-O

Further ADJ B-O
kinetic ADJ B-O
studies NOUN B-O
allow VERB B-O
the DET B-O
first ADJ B-O
snapshot NOUN B-O
on ADP B-O
how SCONJ B-O
silver NOUN B-LF
kills VERB B-O
E. PROPN B-O
coli NOUN B-O
to PART B-O
be AUX B-O
captured VERB B-O
at ADP B-O
the DET B-O
molecular ADJ B-O
level NOUN B-O
( PUNCT B-O
Fig PROPN B-O
4C NUM B-O
) PUNCT B-O
. PUNCT B-O

Ag+ PROPN B-AC
, PUNCT B-O
once ADV B-O
uptaken VERB B-O
inside ADP B-O
E. PROPN B-O
coli NOUN B-O
cell NOUN B-O
, PUNCT B-O
primarily ADV B-O
targets VERB B-O
glycolysis NOUN B-O
and CCONJ B-O
the DET B-O
oxidative ADJ B-O
branch NOUN B-O
of ADP B-O
the DET B-O
TCA PROPN B-AC
cycle NOUN B-O
( PUNCT B-O
or CCONJ B-O
pyruvate NOUN B-O
cycle NOUN B-O
) PUNCT B-O
via ADP B-O
functional ADJ B-O
disruption NOUN B-O
of ADP B-O
the DET B-O
key ADJ B-O
enzymes NOUN B-O
, PUNCT B-O
followed VERB B-O
by ADP B-O
adaptive ADJ B-O
glyoxylate NOUN B-O
cycle NOUN B-O
, PUNCT B-O
and CCONJ B-O
then ADV B-O
abolishes VERB B-O
bacterial ADJ B-O
oxidative ADJ B-O
defense NOUN B-O
capability NOUN B-O
through ADP B-O
binding NOUN B-O
and CCONJ B-O
inactivation NOUN B-O
of ADP B-O
key ADJ B-O
antioxidant ADJ B-O
enzymes NOUN B-O
. PUNCT B-O

Second X B-O
, PUNCT B-O
we PRON B-O
defined VERB B-O
people NOUN B-O
receiving VERB B-O
long ADJ B-O
- PUNCT B-O
term NOUN B-O
opioid NOUN B-LF
pain NOUN I-LF
therapy NOUN I-LF
( PUNCT B-O
OPT PROPN B-AC
) PUNCT B-O
as ADP B-O
those PRON B-O
who PRON B-O
had VERB B-O
90 NUM B-O
unique ADJ B-O
days NOUN B-O
of ADP B-O
therapy NOUN B-O
with ADP B-O
opioids NOUN B-O
indicated VERB B-O
to ADP B-O
treat VERB B-O
pain NOUN B-O
in ADP B-O
the DET B-O
100 NUM B-O
days NOUN B-O
prior ADV B-O
to ADP B-O
or CCONJ B-O
including VERB B-O
enrolment NOUN B-O
termination NOUN B-O
. PUNCT B-O

Despite SCONJ B-O
more ADJ B-O
than ADP B-O
two NUM B-O
decades NOUN B-O
of ADP B-O
research NOUN B-O
on ADP B-O
adherence NOUN B-O
to ADP B-O
antiretroviral ADJ B-LF
therapy NOUN I-LF
( PUNCT B-O
ART PROPN B-AC
) PUNCT B-O
and CCONJ B-O
more ADJ B-O
than ADP B-O
17 NUM B-O
million NUM B-O
HIV PROPN B-O
- PUNCT B-O
positive ADJ B-O
individuals NOUN B-O
on ADP B-O
treatment NOUN B-O
, PUNCT B-O
adherence NOUN B-O
to ADP B-O
ART PROPN B-AC
remains VERB B-O
a DET B-O
major ADJ B-O
challenge NOUN B-O
. PUNCT B-O

To PART B-O
further ADV B-O
evaluate VERB B-O
the DET B-O
inhibitory ADJ B-O
effects NOUN B-O
of ADP B-O
these DET B-O
two NUM B-O
compounds NOUN B-O
on ADP B-O
bacterial ADJ B-O
growth NOUN B-O
, PUNCT B-O
the DET B-O
compounds NOUN B-O
were AUX B-O
supplemented VERB B-O
into ADP B-O
the DET B-O
culture NOUN B-O
medium NOUN B-O
of ADP B-O
H. NOUN B-O
pylori PROPN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
pH NOUN B-O
of ADP B-O
brucella NOUN B-O
broth NOUN B-O
medium NOUN B-O
was AUX B-O
then ADV B-O
adjusted VERB B-O
to ADP B-O
5.0 NUM B-O
with ADP B-O
sterile ADJ B-O
dilute ADJ B-O
hydrochloric ADJ B-LF
acid NOUN I-LF
( PUNCT B-O
HCl PROPN B-AC
) PUNCT B-O
; PUNCT B-O
inoculum NOUN B-O
was AUX B-O
added VERB B-O
to ADP B-O
an DET B-O
initial ADJ B-O
optical ADJ B-O
density NOUN B-O
at ADP B-O
600 NUM B-O
nm NOUN B-O
( PUNCT B-O
OD600 NUM B-O
) PUNCT B-O
of ADP B-O
ca X B-O
. PUNCT B-O

0.1 NUM B-O
. PUNCT B-O

The DET B-O
authors NOUN B-O
, PUNCT B-O
in ADP B-O
a DET B-O
previous ADJ B-O
article NOUN B-O
“ PUNCT B-O
Recommendation NOUN B-O
for ADP B-O
ISTH PROPN B-O
/ SYM B-O
SSC PROPN B-O
Criterion NOUN B-O
2015 NUM B-O
for ADP B-O
autoimmune ADJ B-LF
acquired VERB I-LF
factor NOUN I-LF
XIII/13 NUM I-LF
deficiency NOUN I-LF
” PUNCT B-O
( PUNCT B-O
Thromb PROPN B-O
Haemost PROPN B-O
2016 NUM B-O
; PUNCT B-O
116:772 NUM B-O
- NUM B-O
774 NUM B-O
) PUNCT B-O
refer VERB B-O
to ADP B-O
this DET B-O
deficiency NOUN B-O
as ADP B-O
AAXIII/13D PROPN B-AC
instead ADV B-O
of ADP B-O
AiF13D. NOUN B-O
Children NOUN B-O
were AUX B-O
defined VERB B-O
as ADP B-O
being AUX B-O
lost VERB B-LF
to PART I-LF
follow NOUN I-LF
- PUNCT I-LF
up ADP I-LF
( PUNCT B-O
LTFU PROPN B-AC
) PUNCT B-O
and CCONJ B-O
were AUX B-O
censored VERB B-O
if SCONJ B-O
they PRON B-O
had VERB B-O
no DET B-O
contact NOUN B-O
with ADP B-O
their PRON B-O
health NOUN B-O
care NOUN B-O
facility NOUN B-O
for ADP B-O
9 NUM B-O
mo NOUN B-O
before ADP B-O
database NOUN B-O
closure NOUN B-O
( PUNCT B-O
visits NOUN B-O
are AUX B-O
scheduled VERB B-O
up ADP B-O
to PART B-O
6 NUM B-O
mo NOUN B-O
apart ADV B-O
and CCONJ B-O
clinic NOUN B-O
visits NOUN B-O
being AUX B-O
delayed VERB B-O
for ADP B-O
up ADP B-O
to PART B-O
3 NUM B-O
mo NOUN B-O
are AUX B-O
possible ADJ B-O
) PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
DDD PROPN B-AC
, PUNCT B-O
defined VERB B-LF
daily ADJ I-LF
dose NOUN I-LF
. PUNCT B-O

NP PROPN B-AC
, PUNCT B-O
normal ADJ B-LF
pregnancy NOUN I-LF
group NOUN B-O
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
observational ADJ B-O
studies NOUN B-O
of ADP B-O
ITN PROPN B-AC
use NOUN B-O
have AUX B-O
consistently ADV B-O
shown VERB B-O
findings NOUN B-O
similar ADJ B-O
to ADP B-O
those PRON B-O
of ADP B-O
randomized VERB B-LF
controlled VERB I-LF
trials NOUN I-LF
( PUNCT B-O
RCTs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
suggesting VERB B-O
that SCONJ B-O
within ADP B-O
specific ADJ B-O
communities NOUN B-O
confounding VERB B-O
is AUX B-O
not PART B-O
pronounced VERB B-O
[ PUNCT B-O
29 NUM B-O
] PUNCT B-O
. PUNCT B-O

On ADP B-O
the DET B-O
other ADJ B-O
hand NOUN B-O
, PUNCT B-O
5-HT PROPN B-AC
concentration NOUN B-O
was AUX B-O
significantly ADV B-O
decreased VERB B-O
in ADP B-O
the DET B-O
platelets NOUN B-O
in ADP B-O
patients NOUN B-O
with ADP B-O
AD PROPN B-AC
[ X B-O
54 X B-O
] PUNCT B-O
and CCONJ B-O
selective ADJ B-O
serotonin NOUN B-LF
reuptake NOUN B-O
inhibitors NOUN B-O
improve VERB B-O
decreased VERB B-O
cognitive ADJ B-O
performance NOUN B-O
and CCONJ B-O
BPSD PROPN B-AC
seen VERB B-O
in ADP B-O
patients NOUN B-O
with ADP B-O
AD PROPN B-AC
[ X B-O
55 NUM B-O
, PUNCT B-O
56 NUM B-O
] PUNCT B-O
. PUNCT B-O

Pre X B-O
= PUNCT B-O
Precision NOUN B-O
score NOUN B-O
, PUNCT B-O
Rec NOUN B-O
= PUNCT B-O
Recall NOUN B-O
score NOUN B-O
, PUNCT B-O
F1 PROPN B-AC
= PUNCT B-O
F1 NOUN B-LF
- PUNCT I-LF
F1 PROPN B-AC
score NOUN I-LF
, PUNCT B-O
AUC PROPN B-AC
= PUNCT B-O
AUC PROPN B-AC
score NOUN B-O
, PUNCT B-O
and CCONJ B-O
A(i NOUN B-O
) PUNCT B-O
= PUNCT B-O
{ PUNCT B-O
Prei NOUN B-O
, PUNCT B-O
Reci PROPN B-O
, PUNCT B-O
F1i X B-O
, PUNCT B-O
AUCi PROPN B-O
} PUNCT B-O
; PUNCT B-O
w(i NOUN B-O
) PUNCT B-O
is AUX B-O
the DET B-O
weight NOUN B-O
generated VERB B-O
for ADP B-O
the DET B-O
ith PROPN B-O
base NOUN B-O
learner NOUN B-O
to PART B-O
compute VERB B-O
the DET B-O
ensemble NOUN B-O
, PUNCT B-O
pj(i NOUN B-O
) PUNCT B-O
is AUX B-O
the DET B-O
probability NOUN B-O
score NOUN B-O
for ADP B-O
the DET B-O
jth ADJ B-O
sample NOUN B-O
by ADP B-O
the DET B-O
ith PROPN B-O
classifier NOUN B-O
, PUNCT B-O
and CCONJ B-O
ensj NOUN B-O
is AUX B-O
the DET B-O
fused VERB B-O
probability NOUN B-O
score NOUN B-O
for ADP B-O
the DET B-O
jth ADJ B-O
sample NOUN B-O
; PUNCT B-O
and CCONJ B-O
the DET B-O
argmax NOUN B-O
function NOUN B-O
returns VERB B-O
the DET B-O
position NOUN B-O
having VERB B-O
the DET B-O
highest ADJ B-O
value NOUN B-O
in ADP B-O
a DET B-O
1D ADJ B-O
array NOUN B-O
, PUNCT B-O
i.e. X B-O
, PUNCT B-O
in ADP B-O
this DET B-O
case NOUN B-O
it PRON B-O
generates VERB B-O
the DET B-O
predicted VERB B-O
class NOUN B-O
of ADP B-O
the DET B-O
sample NOUN B-O
. PUNCT B-O

This PRON B-O
indicates VERB B-O
that SCONJ B-O
a DET B-O
Chromosome NOUN B-O
4 NUM B-O
bivalent ADJ B-O
experiences VERB B-O
on ADP B-O
average ADJ B-O
1.76 NUM B-O
CO PROPN B-AC
in ADP B-O
male ADJ B-LF
meiosis NOUN B-O
, PUNCT B-O
but CCONJ B-O
only ADV B-O
1.05 NUM B-O
CO PROPN B-AC
in ADP B-O
female ADJ B-LF
meiosis NOUN B-O
( PUNCT B-O
M PROPN B-AC
/ SYM B-O
F PROPN B-AC
ratio NOUN B-O
1.68 NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
results NOUN B-O
in ADP B-O
this DET B-O
section NOUN B-O
were AUX B-O
confirmed VERB B-O
by ADP B-O
NCBI PROPN B-O
’s PART B-O
Conserved PROPN B-LF
Domain PROPN I-LF
Database PROPN I-LF
( PUNCT B-O
CDD PROPN B-AC
) PUNCT B-O
[ X B-O
93 X B-O
] X B-O
matches NOUN B-O
obtained VERB B-O
using VERB B-O
rpsblast PROPN B-O
with ADP B-O
composition NOUN B-O
- PUNCT B-O
based VERB B-O
statistics NOUN B-O
and CCONJ B-O
masking VERB B-O
low ADJ B-O
- PUNCT B-O
information NOUN B-O
regions NOUN B-O
. PUNCT B-O

A X B-O
range NOUN B-O
of ADP B-O
virulence NOUN B-O
assays NOUN B-O
were AUX B-O
performed VERB B-O
on ADP B-O
a DET B-O
subset NOUN B-O
of ADP B-O
10 NUM B-O
high- ADJ B-O
and CCONJ B-O
10 NUM B-O
low ADJ B-O
- PUNCT B-O
toxicity NOUN B-O
isolates NOUN B-O
from ADP B-O
the DET B-O
USA300 PROPN B-O
collection NOUN B-O
to PART B-O
identify VERB B-O
the DET B-O
biological ADJ B-O
feature NOUN B-O
that PRON B-O
explains VERB B-O
the DET B-O
observed VERB B-O
inverse ADJ B-O
correlation NOUN B-O
between ADP B-O
toxicity NOUN B-O
and CCONJ B-O
disease NOUN B-O
severity NOUN B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
The DET B-O
toxicity NOUN B-O
of ADP B-O
the DET B-O
subset NOUN B-O
of ADP B-O
isolates NOUN B-O
is AUX B-O
provided VERB B-O
for ADP B-O
comparison NOUN B-O
. PUNCT B-O

( PUNCT B-O
B NOUN B-O
) PUNCT B-O
The DET B-O
ability NOUN B-O
of ADP B-O
the DET B-O
bacteria NOUN B-O
to PART B-O
invade VERB B-O
EA.hy926 NOUN B-O
endothelial ADJ B-O
cells NOUN B-O
. PUNCT B-O

( PUNCT B-O
C X B-O
) PUNCT B-O
The DET B-O
ability NOUN B-O
of ADP B-O
the DET B-O
bacteria NOUN B-O
to PART B-O
induce VERB B-O
the DET B-O
release NOUN B-O
of ADP B-O
neutrophil NOUN B-LF
extracellular ADJ I-LF
traps NOUN I-LF
( PUNCT B-O
NETs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
D X B-O
) PUNCT B-O
The DET B-O
release NOUN B-O
of ADP B-O
proteases NOUN B-O
by ADP B-O
the DET B-O
bacteria NOUN B-O
. PUNCT B-O

( PUNCT B-O
E X B-O
) PUNCT B-O
Resistance NOUN B-O
of ADP B-O
the DET B-O
bacteria NOUN B-O
to PART B-O
human ADJ B-O
neutrophil NOUN B-O
defensin-1 NOUN B-O
. PUNCT B-O

( PUNCT B-O
F X B-O
) PUNCT B-O
The DET B-O
ability NOUN B-O
of ADP B-O
the DET B-O
bacteria NOUN B-O
to PART B-O
form VERB B-O
biofilms NOUN B-O
. PUNCT B-O

Although SCONJ B-O
the DET B-O
percentage NOUN B-O
of ADP B-O
women NOUN B-O
attending VERB B-O
Focused PROPN B-LF
Antenatal PROPN I-LF
Care PROPN I-LF
( PUNCT B-O
FANC PROPN B-AC
) PUNCT B-O
for ADP B-O
at ADP B-O
least ADV B-O
once ADV B-O
generally ADV B-O
tends VERB B-O
to PART B-O
be AUX B-O
satisfactory ADJ B-O
even ADV B-O
in ADP B-O
low ADJ B-O
- PUNCT B-O
income NOUN B-O
countries NOUN B-O
, PUNCT B-O
maternal ADJ B-O
and CCONJ B-O
neonatal ADJ B-O
mortality NOUN B-O
remain VERB B-O
high ADJ B-O
. PUNCT B-O

Cycloheximide NOUN B-O
was AUX B-O
added VERB B-O
at ADP B-O
time NOUN B-O
= CCONJ B-O
0 NUM B-O
and CCONJ B-O
the DET B-O
amount NOUN B-O
of ADP B-O
Gal80 NOUN B-O
protein NOUN B-O
remaining VERB B-O
in ADP B-O
the DET B-O
cells NOUN B-O
after ADP B-O
the DET B-O
indicated VERB B-O
number NOUN B-O
of ADP B-O
hours NOUN B-O
was AUX B-O
determined VERB B-O
by ADP B-O
Western ADJ B-O
blot NOUN B-O
with ADP B-O
the DET B-O
help NOUN B-O
of ADP B-O
an DET B-O
anti ADJ B-O
- ADJ B-O
hemagglutinin ADJ B-LF
( PUNCT B-O
HA PROPN B-AC
) PUNCT B-O
antibody NOUN B-O
( PUNCT B-O
upper ADJ B-O
panels NOUN B-O
) PUNCT B-O
. PUNCT B-O

Dpp PROPN B-AC
, PUNCT B-O
Decapentaplegic PROPN B-LF
; PUNCT B-O
Hh PROPN B-AC
, PUNCT B-O
Hedgehog PROPN B-LF
. PUNCT B-O

The DET B-O
most ADV B-O
common ADJ B-O
alternative ADJ B-O
infectious ADJ B-LF
disease NOUN I-LF
( PUNCT B-O
ID)—diagnoses PROPN B-AC
were AUX B-O
pneumonia NOUN B-O
( PUNCT B-O
n NOUN B-O
= PUNCT B-O
30 NUM B-O
) PUNCT B-O
, PUNCT B-O
infection NOUN B-O
of ADP B-O
totally ADV B-O
implantable ADJ B-O
venous ADJ B-O
access NOUN B-O
device NOUN B-O
( PUNCT B-O
port NOUN B-O
, PUNCT B-O
n NOUN B-O
= PUNCT B-O
9 NUM B-O
) PUNCT B-O
, PUNCT B-O
skin NOUN B-LF
and CCONJ I-LF
soft ADJ I-LF
tissue NOUN I-LF
infection NOUN I-LF
( PUNCT B-O
SSTI PROPN B-AC
, PUNCT B-O
n NOUN B-O
= PUNCT B-O
9 NUM B-O
) PUNCT B-O
and CCONJ B-O
influenza NOUN B-O
( PUNCT B-O
n NOUN B-O
= PUNCT B-O
4 NUM B-O
) PUNCT B-O
. PUNCT B-O

Lysates NOUN B-O
derived VERB B-O
from ADP B-O
virions NOUN B-O
containing VERB B-O
HA PROPN B-O
- PUNCT B-O
tagged VERB B-O
A3G PROPN B-AC
were AUX B-O
size NOUN B-O
- PUNCT B-O
fractionated VERB B-O
by ADP B-O
fast ADJ B-LF
protein NOUN I-LF
liquid NOUN I-LF
chromatography NOUN I-LF
( PUNCT B-O
FPLC PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Each DET B-O
fraction NOUN B-O
was AUX B-O
then ADV B-O
analyzed VERB B-O
by ADP B-O
SDS PROPN B-O
- PUNCT B-O
PAGE PROPN B-O
and CCONJ B-O
immunoblotting VERB B-O
with ADP B-O
anti ADJ B-O
- PUNCT B-O
HA PROPN B-O
monoclonal ADJ B-O
antibodies NOUN B-O
( PUNCT B-O
Figure PROPN B-O
3A NUM B-O
) PUNCT B-O
. PUNCT B-O

Surprisingly ADV B-O
, PUNCT B-O
virion NOUN B-O
- PUNCT B-O
incorporated VERB B-O
HA PROPN B-O
- PUNCT B-O
A3 PROPN B-AC
was AUX B-O
detected VERB B-O
almost ADV B-O
exclusively ADV B-O
in ADP B-O
the DET B-O
GHMM PROPN B-AC
region NOUN B-O
, PUNCT B-O
eluting VERB B-O
in ADP B-O
the DET B-O
void ADJ B-O
volume NOUN B-O
of ADP B-O
the DET B-O
Superose PROPN B-O
6 NUM B-O
column NOUN B-O
( PUNCT B-O
Figure PROPN B-O
3A NUM B-O
) PUNCT B-O
. PUNCT B-O

This DET B-O
result NOUN B-O
was AUX B-O
not PART B-O
due ADJ B-O
to ADP B-O
incomplete ADJ B-O
lysis NOUN B-O
of ADP B-O
the DET B-O
virion NOUN B-O
cores NOUN B-O
since SCONJ B-O
the DET B-O
p24 NOUN B-O
viral ADJ B-O
capsid NOUN B-LF
( PUNCT B-O
p24 NOUN B-O
- PUNCT B-O
CA PROPN B-AC
) PUNCT B-O
was AUX B-O
detected VERB B-O
only ADV B-O
in ADP B-O
the DET B-O
expected VERB B-O
LMM PROPN B-AC
fractions NOUN B-O
. PUNCT B-O

Inward ADJ B-LF
rectifier NOUN I-LF
potassium NOUN I-LF
current NOUN I-LF
( PUNCT B-O
IK1 PROPN B-AC
) PUNCT B-O
was AUX B-O
measured VERB B-O
by ADP B-O
determining VERB B-O
the DET B-O
steady ADJ B-O
- PUNCT B-O
state NOUN B-O
current NOUN B-O
at ADP B-O
the DET B-O
end NOUN B-O
of ADP B-O
300 NUM B-O
ms NOUN B-O
long ADJ B-O
pulses NOUN B-O
clamped VERB B-O
to ADP B-O
potentials NOUN B-O
ranging VERB B-O
from ADP B-O
-80 NUM B-O
to ADP B-O
0 NUM B-O
mV. NOUN B-O
FFS PROPN B-AC
, PUNCT B-O
Medicare PROPN B-LF
fee NOUN I-LF
- PUNCT I-LF
for ADP I-LF
- PUNCT I-LF
service NOUN I-LF
; PUNCT B-O
IPTW PROPN B-AC
, PUNCT B-O
inverse ADJ B-LF
probability NOUN I-LF
of ADP I-LF
treatment NOUN I-LF
weighting NOUN I-LF
; PUNCT B-O
MA PROPN B-AC
, PUNCT B-O
Medicare PROPN B-LF
Advantage PROPN I-LF
; PUNCT B-O
SNF PROPN B-AC
, PUNCT B-O
skilled ADJ B-LF
nursing NOUN I-LF
facility NOUN I-LF
. PUNCT B-O

Weak ADJ B-O
CGIs PROPN B-AC
may AUX B-O
be AUX B-O
depleted VERB B-O
because SCONJ B-O
they PRON B-O
are AUX B-O
heavily ADV B-O
methylated VERB B-O
and CCONJ B-O
therefore ADV B-O
not PART B-O
enriched VERB B-O
by ADP B-O
CAP PROPN B-AC
. PUNCT B-O

Indeed ADV B-O
, PUNCT B-O
22 NUM B-O
methylated VERB B-O
weak ADJ B-O
CpG NOUN B-LF
islands NOUN I-LF
[ X B-O
14 X B-O
] X B-O
were AUX B-O
not PART B-O
detected VERB B-O
in ADP B-O
our PRON B-O
library NOUN B-O
. PUNCT B-O

Thus ADV B-O
, PUNCT B-O
it PRON B-O
is AUX B-O
necessary ADJ B-O
to PART B-O
test VERB B-O
our PRON B-O
hypothesis NOUN B-O
that SCONJ B-O
the DET B-O
treatment NOUN B-O
of ADP B-O
stroke NOUN B-O
with ADP B-O
BMSC PROPN B-AC
has AUX B-O
therapeutic ADJ B-O
efficacy NOUN B-O
in ADP B-O
the DET B-O
most ADV B-O
common ADJ B-O
form NOUN B-O
of ADP B-O
diabetes NOUN B-O
, PUNCT B-O
type NOUN B-LF
2 NUM I-LF
diabetes NOUN I-LF
mellitus NOUN I-LF
( PUNCT B-O
T2DM PROPN B-AC
) PUNCT B-O
. PUNCT B-O

T2DM PROPN B-AC
was AUX B-O
induced VERB B-O
in ADP B-O
adult ADJ B-O
male ADJ B-O
Wistar PROPN B-O
rats NOUN B-O
by ADP B-O
administration NOUN B-O
of ADP B-O
a DET B-O
high ADJ B-O
fat NOUN B-O
diet NOUN B-O
in ADP B-O
combination NOUN B-O
with ADP B-O
a DET B-O
single ADJ B-O
intraperitoneal ADJ B-O
injection NOUN B-O
( PUNCT B-O
35mg NUM B-O
/ SYM B-O
kg NOUN B-O
) PUNCT B-O
of ADP B-O
streptozotocin NOUN B-O
. PUNCT B-O

There PRON B-O
are AUX B-O
eight NUM B-O
mammalian ADJ B-O
IAPs NOUN B-O
. PUNCT B-O

Some DET B-O
IAPs NOUN B-O
also ADV B-O
contain VERB B-O
a DET B-O
RING NOUN B-O
motif NOUN B-O
that PRON B-O
confers VERB B-O
ubiquitin NOUN B-O
protein NOUN B-O
ligase NOUN B-O
( PUNCT B-O
E3 NOUN B-O
) PUNCT B-O
activity NOUN B-O
. PUNCT B-O

c NOUN B-O
- PUNCT B-O
IAP1 PROPN B-O
and CCONJ B-O
c NOUN B-O
- PUNCT B-O
IAP2 PROPN B-O
are AUX B-O
such ADJ B-O
RING NOUN B-O
- PUNCT B-O
containing VERB B-O
proteins NOUN B-O
that PRON B-O
bind VERB B-O
caspase-7 NOUN B-O
or CCONJ B-O
-9 NUM B-O
but CCONJ B-O
, PUNCT B-O
unlike ADP B-O
XIAP PROPN B-O
, PUNCT B-O
do AUX B-O
not PART B-O
inhibit VERB B-O
their PRON B-O
enzymatic ADJ B-O
activities NOUN B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

c NOUN B-O
- PUNCT B-O
IAP1 PROPN B-O
and CCONJ B-O
c NOUN B-O
- PUNCT B-O
IAP2 PROPN B-O
also ADV B-O
bind VERB B-O
the DET B-O
adaptor NOUN B-O
protein NOUN B-O
TNF PROPN B-LF
Receptor PROPN I-LF
Associated PROPN I-LF
Factor PROPN I-LF
2 NUM I-LF
( PUNCT B-O
TRAF2 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
are AUX B-O
components NOUN B-O
of ADP B-O
the DET B-O
Tumor PROPN B-LF
Necrosis PROPN I-LF
Factor PROPN I-LF
Receptor PROPN I-LF
1 NUM I-LF
( PUNCT B-O
TNF-R1 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
2 NUM B-O
signaling NOUN B-O
complexes NOUN B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Fig NOUN B-O
1A–1C NOUN B-O
shows VERB B-O
that SCONJ B-O
hearts NOUN B-O
exposed VERB B-O
to ADP B-O
40 NUM B-O
minutes NOUN B-O
of ADP B-O
ischemia NOUN B-O
and CCONJ B-O
60 NUM B-O
minutes NOUN B-O
of ADP B-O
reperfusion NOUN B-O
( PUNCT B-O
I/R PROPN B-AC
) PUNCT B-O
suffered VERB B-O
a DET B-O
significant ADJ B-O
decrease NOUN B-O
in ADP B-O
the DET B-O
left ADJ B-LF
ventricular ADJ I-LF
developed VERB I-LF
pressure NOUN I-LF
( PUNCT B-O
LVDP PROPN B-AC
) PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
in ADP B-O
the DET B-O
positive ADJ B-O
and CCONJ B-O
negative ADJ B-O
maximum ADJ B-O
derivative NOUN B-LF
of ADP I-LF
left ADJ I-LF
ventricular ADJ I-LF
pressure NOUN I-LF
( PUNCT B-O
±dP NOUN B-O
) PUNCT B-O
, PUNCT B-O
indicating VERB B-O
significant ADJ B-O
loss NOUN B-O
in ADP B-O
heart NOUN B-O
function NOUN B-O
. PUNCT B-O

CK-666 PROPN B-AC
, PUNCT B-O
Arp2/3 NOUN B-LF
complex NOUN I-LF
Arp2/3 PROPN B-AC
inhibitor NOUN I-LF
I. NOUN I-LF
Data NOUN B-O
are AUX B-O
shown VERB B-O
as ADP B-O
mean NOUN B-O
± ADJ B-O
SEM NOUN B-O
. PUNCT B-O

AAV PROPN B-O
, PUNCT B-O
adeno NOUN B-O
- PUNCT B-O
associated VERB B-O
virus NOUN B-O
; PUNCT B-O
ARC PROPN B-AC
, PUNCT B-O
arcuate ADJ B-LF
nucleus NOUN I-LF
of ADP I-LF
the DET I-LF
hypothalamus NOUN I-LF
; PUNCT B-O
cap NOUN B-O
, PUNCT B-O
capsaicin NOUN B-O
; PUNCT B-O
CNO PROPN B-AC
, PUNCT B-O
clozapine NOUN B-LF
- PUNCT I-LF
N NOUN I-LF
- PUNCT I-LF
oxide NOUN I-LF
; PUNCT B-O
Cre PROPN B-AC
, PUNCT B-O
Cre PROPN B-LF
recombinase NOUN I-LF
Cre PROPN B-AC
; PUNCT B-O
DREADD PROPN B-AC
, PUNCT B-O
designer NOUN B-LF
receptor NOUN I-LF
exclusively ADV I-LF
activated VERB I-LF
by ADP I-LF
designer NOUN I-LF
drugs NOUN I-LF
; PUNCT B-O
hSyn PROPN B-AC
, PUNCT B-O
human ADJ B-LF
synapsin NOUN I-LF
I NUM I-LF
promoter NOUN I-LF
; PUNCT B-O
i.p NOUN B-O
. PUNCT B-O

, PUNCT B-O
Intraperitoneal NOUN B-O
; PUNCT B-O
mCherry PROPN B-AC
, PUNCT B-O
monomeric ADJ B-LF
cherry NOUN I-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
MC3/4 PROPN B-O
, PUNCT B-O
melanocortin NOUN B-O
3/4 NUM B-O
; PUNCT B-O
POMC PROPN B-AC
, PUNCT B-O
proopiomelanocortin NOUN B-LF
; PUNCT B-O
RTX PROPN B-AC
, PUNCT B-O
resiniferatoxin NOUN B-LF
; PUNCT B-O
sal NOUN B-O
, PUNCT B-O
saline NOUN B-O
; PUNCT B-O
TRPV1 PROPN B-AC
, PUNCT B-O
transient ADJ B-LF
receptor NOUN I-LF
potential ADJ I-LF
vanilloid NOUN I-LF
1 NUM I-LF
receptor NOUN I-LF
. PUNCT B-O

Targeted VERB B-LF
radionuclide NOUN I-LF
therapy NOUN I-LF
( PUNCT B-O
TRNT PROPN B-AC
) PUNCT B-O
with ADP B-O
alpha NOUN B-O
particles NOUN B-O
is AUX B-O
thus ADV B-O
complementary ADJ B-O
to ADP B-O
TRNT PROPN B-AC
with ADP B-O
beta NOUN B-O
particles NOUN B-O
, PUNCT B-O
whose DET B-O
millimetric ADJ B-O
path NOUN B-O
is AUX B-O
better ADV B-O
suited ADJ B-O
to ADP B-O
bulky ADJ B-O
tumour NOUN B-O
treatment NOUN B-O
. PUNCT B-O

One NUM B-O
part NOUN B-O
is AUX B-O
called VERB B-O
GP PROPN B-AC
( PUNCT B-O
which PRON B-O
stands VERB B-O
for ADP B-O
glycoprotein NOUN B-LF
) PUNCT B-O
and CCONJ B-O
is AUX B-O
from ADP B-O
the DET B-O
outer ADJ B-O
coat NOUN B-O
of ADP B-O
the DET B-O
virus NOUN B-O
; PUNCT B-O
the DET B-O
other ADJ B-O
, PUNCT B-O
NP PROPN B-AC
( PUNCT B-O
nucleoprotein NOUN B-LF
) PUNCT B-O
, PUNCT B-O
is AUX B-O
from ADP B-O
its PRON B-O
inside NOUN B-O
. PUNCT B-O

Bioreactors NOUN B-O
were AUX B-O
filled VERB B-O
with ADP B-O
different ADJ B-O
mixtures NOUN B-O
of ADP B-O
WAS PROPN B-AC
substrate NOUN B-O
and CCONJ B-O
a DET B-O
co NOUN B-O
- NOUN B-O
substrate NOUN B-O
( PUNCT B-O
FW PROPN B-AC
or CCONJ B-O
GG PROPN B-AC
) PUNCT B-O
prepared VERB B-O
in ADP B-O
different ADJ B-O
proportions NOUN B-O
of ADP B-O
grams NOUN B-O
of ADP B-O
chemical ADJ B-LF
oxygen NOUN I-LF
demand NOUN I-LF
( PUNCT B-O
COD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

These DET B-O
proportions NOUN B-O
consisted VERB B-O
of ADP B-O
0/100 NUM B-O
, PUNCT B-O
25/75 NUM B-O
, PUNCT B-O
50/50 NUM B-O
, PUNCT B-O
75/25 NUM B-O
, PUNCT B-O
and CCONJ B-O
100/0 NUM B-O
gCOD NOUN B-O
WAS PROPN B-AC
/ SYM B-O
gCOD NOUN B-O
co NOUN B-O
- NOUN B-O
substrate NOUN B-O
. PUNCT B-O

We PRON B-O
appraised VERB B-O
the DET B-O
certainty NOUN B-O
of ADP B-O
the DET B-O
key ADJ B-O
elements NOUN B-O
according VERB B-O
to ADP B-O
the DET B-O
Grading PROPN B-LF
of ADP I-LF
Recommendations PROPN I-LF
Assessment PROPN I-LF
, PUNCT I-LF
Development PROPN I-LF
and CCONJ I-LF
Evaluation PROPN I-LF
( PUNCT B-O
GRADE PROPN B-AC
) PUNCT B-O
tool NOUN B-O
[ PUNCT B-O
29–31 NUM B-O
] X B-O
( PUNCT B-O
S3 PROPN B-O
Table NOUN B-O
) PUNCT B-O
. PUNCT B-O

H PROPN B-AC
’s PART B-O
Byproduct NOUN B-LF
B PROPN B-AC
is AUX B-O
required VERB B-O
by ADP B-O
Manufacturer NOUN B-LF
FISH PROPN B-AC
, PUNCT B-O
fluorescence NOUN B-LF
in ADP I-LF
situ ADJ I-LF
hybridization NOUN I-LF
; PUNCT B-O
SIM PROPN B-AC
, PUNCT B-O
structured ADJ B-LF
illumination NOUN I-LF
microscopy NOUN I-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
type NOUN I-LF
. PUNCT B-O

AMP NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT B-O
AMPK PROPN B-AC
) PUNCT B-O
is AUX B-O
an DET B-O
evolutionarily ADV B-O
- PUNCT B-O
conserved VERB B-O
fuel NOUN B-O
- PUNCT B-O
sensitive ADJ B-O
serine NOUN B-O
/ SYM B-O
threonine NOUN B-O
protein NOUN B-O
kinase NOUN B-O
and CCONJ B-O
cellular ADJ B-O
nutrient NOUN B-O
sensor NOUN B-O
implicated VERB B-O
in ADP B-O
the DET B-O
regulation NOUN B-O
of ADP B-O
energy NOUN B-O
homeostasis NOUN B-O
[ PUNCT B-O
19 X B-O
] PUNCT B-O
[ PUNCT B-O
20 NUM B-O
] PUNCT B-O
. PUNCT B-O

Such ADJ B-O
measurement NOUN B-O
results VERB B-O
in ADP B-O
various ADJ B-O
coupling NOUN B-O
metrics NOUN B-O
, PUNCT B-O
which PRON B-O
can AUX B-O
be AUX B-O
considered VERB B-O
as ADP B-O
assessor NOUN B-O
of ADP B-O
design NOUN B-O
stability NOUN B-O
of ADP B-O
classes NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
Coupling NOUN B-LF
Between ADP I-LF
Object PROPN I-LF
( PUNCT B-O
CBO PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Response NOUN B-LF
For ADP I-LF
a DET I-LF
Class NOUN I-LF
( PUNCT B-O
RFC PROPN B-AC
) PUNCT B-O
from ADP B-O
Chidamber PROPN B-O
and CCONJ B-O
Kemerer PROPN B-O
’s PART B-O
metrics NOUN B-O
suit VERB B-O
[ PUNCT B-O
9 NUM B-O
, PUNCT B-O
11 NUM B-O
] PUNCT B-O
, PUNCT B-O
Data PROPN B-LF
Abstraction NOUN I-LF
Coupling NOUN I-LF
( PUNCT B-O
DAC PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Measure NOUN B-LF
of ADP I-LF
Aggregation NOUN I-LF
( PUNCT B-O
MOA PROPN B-AC
) PUNCT B-O
from ADP B-O
QMOOD PROPN B-O
[ PUNCT B-O
10 NUM B-O
] PUNCT B-O
and CCONJ B-O
Message NOUN B-LF
Passing NOUN I-LF
Coupling NOUN I-LF
( PUNCT B-O
MPC PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
12 NUM B-O
] PUNCT B-O
. PUNCT B-O

Peripheral ADJ B-O
blood NOUN B-O
mononuclear ADJ B-O
cells NOUN B-O
from ADP B-O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
( PUNCT B-O
ICU PROPN B-AC
) PUNCT B-O
patients NOUN B-O
with ADP B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
30 NUM B-O
) PUNCT B-O
and CCONJ B-O
without ADP B-O
sepsis NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
10 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
healthy ADJ B-O
volunteers NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
15 NUM B-O
) PUNCT B-O
were AUX B-O
isolated VERB B-O
using VERB B-O
Ficoll PROPN B-O
density NOUN B-O
gradient NOUN B-O
centrifugation NOUN B-O
. PUNCT B-O

The DET B-O
data NOUN B-O
were AUX B-O
then ADV B-O
separated VERB B-O
into ADP B-O
local ADJ B-LF
field NOUN I-LF
potentials NOUN I-LF
( PUNCT B-O
LFPs PROPN B-AC
; PUNCT B-O
1–150 NUM B-O
Hz NOUN B-O
) PUNCT B-O
and CCONJ B-O
isolated VERB B-O
single ADJ B-O
- PUNCT B-O
unit NOUN B-O
activity NOUN B-O
( PUNCT B-O
0.5–10 NUM B-O
kHz NOUN B-O
) PUNCT B-O
. PUNCT B-O

Prostate ADJ B-LF
cancer NOUN I-LF
( PUNCT B-O
PCa PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
most ADV B-O
common ADJ B-O
malignancy NOUN B-O
in ADP B-O
men NOUN B-O
and CCONJ B-O
is AUX B-O
the DET B-O
second ADJ B-O
leading VERB B-O
cause NOUN B-O
of ADP B-O
cancer NOUN B-O
deaths NOUN B-O
worldwide ADV B-O
. PUNCT B-O

Whereas SCONJ B-O
the DET B-O
impact NOUN B-O
of ADP B-O
the DET B-O
G PROPN B-O
allele NOUN B-O
on ADP B-O
the DET B-O
liver NOUN B-O
fibrosis NOUN B-O
progression NOUN B-O
in ADP B-O
chronic ADJ B-O
hepatitis NOUN B-O
C PROPN B-O
seems VERB B-O
to PART B-O
be AUX B-O
well ADV B-O
known VERB B-O
, PUNCT B-O
its PRON B-O
impact NOUN B-O
on ADP B-O
chronic ADJ B-LF
liver NOUN I-LF
failure NOUN I-LF
( PUNCT B-O
CLF PROPN B-AC
) PUNCT B-O
progression NOUN B-O
and CCONJ B-O
the DET B-O
need NOUN B-O
of ADP B-O
LT PROPN B-AC
has AUX B-O
not PART B-O
been AUX B-O
described VERB B-O
so ADV B-O
far ADV B-O
. PUNCT B-O

First ADV B-O
, PUNCT B-O
S PROPN B-AC
forms VERB B-O
Watson PROPN B-O
– PUNCT B-O
Crick PROPN B-O
base NOUN B-O
pairs NOUN B-O
with ADP B-O
the DET B-O
ribozyme NOUN B-LF
's PART B-O
internal ADJ B-O
guide NOUN B-O
sequence NOUN B-O
( PUNCT B-O
see VERB B-O
Figure PROPN B-O
2A NUM B-O
) PUNCT B-O
to PART B-O
give VERB B-O
the DET B-O
open ADJ B-O
complex NOUN B-O
( PUNCT B-O
In ADP B-O
total NOUN B-O
, PUNCT B-O
these DET B-O
US PROPN B-O
healthcare NOUN B-O
- PUNCT B-O
related VERB B-O
emissions NOUN B-O
result VERB B-O
in ADP B-O
an DET B-O
estimated VERB B-O
annual ADJ B-O
loss NOUN B-O
of ADP B-O
614,000 NUM B-O
disability NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
years NOUN I-LF
( PUNCT B-O
DALYs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
only ADJ B-O
such ADJ B-O
national ADJ B-O
damage NOUN B-O
estimate NOUN B-O
to ADP B-O
date NOUN B-O
[ PUNCT B-O
7,24 NUM B-O
] PUNCT B-O
. PUNCT B-O

For ADP B-O
example NOUN B-O
, PUNCT B-O
one NUM B-O
pair NOUN B-O
from ADP B-O
this DET B-O
region NOUN B-O
is AUX B-O
shown VERB B-O
to ADP B-O
be AUX B-O
expressed VERB B-O
from ADP B-O
chromosome NOUN B-O
8q24.21 NUM B-O
, PUNCT B-O
and CCONJ B-O
it PRON B-O
forms VERB B-O
a DET B-O
stable ADJ B-O
ndsRNA PROPN B-AC
molecule NOUN B-O
( PUNCT B-O
nds-2a NOUN B-O
) PUNCT B-O
that PRON B-O
binds VERB B-O
to ADP B-O
regulator NOUN B-LF
of ADP I-LF
chromosome NOUN I-LF
condensation NOUN I-LF
1 NUM I-LF
( PUNCT B-O
RCC1 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
ras NOUN B-LF
- PUNCT I-LF
related VERB I-LF
nuclear ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
RAN PROPN B-AC
) PUNCT B-O
and CCONJ B-O
through ADP B-O
the DET B-O
latter ADJ B-O
, PUNCT B-O
with ADP B-O
the DET B-O
mitotic ADJ B-O
RANGAP1 NOUN B-O
- PUNCT B-O
SUMO1 NOUN B-O
- PUNCT B-O
RANBP2 NOUN B-O
complex NOUN B-O
[ PUNCT B-O
64 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
gene NOUN B-O
expression NOUN B-O
of ADP B-O
FA PROPN B-AC
synthase NOUN B-O
( PUNCT B-O
FASN PROPN B-AC
) PUNCT B-O
, PUNCT B-O
lipoprotein NOUN B-LF
lipase NOUN I-LF
( PUNCT B-O
LPL PROPN B-AC
) PUNCT B-O
, PUNCT B-O
stearoyl NOUN B-O
- PUNCT B-O
CoA NOUN B-O
desaturase NOUN B-O
( PUNCT B-O
SCD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
FA PROPN B-AC
desaturase NOUN B-O
1 NUM B-O
( PUNCT B-O
FADS1 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
FA PROPN B-AC
elongase NOUN B-O
5 NUM B-O
( PUNCT B-O
ELOVL5 PROPN B-AC
) PUNCT B-O
were AUX B-O
measured VERB B-O
in ADP B-O
muscle NOUN B-O
. PUNCT B-O

Interactions NOUN B-O
of ADP B-O
MYPT1 PROPN B-AC
and CCONJ B-O
its PRON B-O
mutants NOUN B-O
with ADP B-O
SNAP-25 PROPN B-AC
were AUX B-O
analysed VERB B-O
by ADP B-O
surface NOUN B-LF
plasmon NOUN I-LF
resonance NOUN I-LF
( PUNCT B-O
SPR PROPN B-AC
) PUNCT B-O
using VERB B-O
a DET B-O
Biacore PROPN B-O
3000 NUM B-O
instrument NOUN B-O
( PUNCT B-O
GE PROPN B-O
Healthcare PROPN B-O
, PUNCT B-O
Little PROPN B-O
Chalfont PROPN B-O
, PUNCT B-O
UK PROPN B-O
) PUNCT B-O
. PUNCT B-O

Anti NOUN B-O
- PUNCT B-O
GST PROPN B-O
was AUX B-O
coupled VERB B-O
on ADP B-O
the DET B-O
surface NOUN B-O
of ADP B-O
a DET B-O
CM5 PROPN B-O
chip NOUN B-O
by ADP B-O
amine NOUN B-O
- PUNCT B-O
coupling NOUN B-O
, PUNCT B-O
then ADV B-O
full ADJ B-O
- PUNCT B-O
length ADJ B-O
GST PROPN B-O
- PUNCT B-O
MYPT1WT NOUN B-O
or CCONJ B-O
its PRON B-O
C NOUN B-O
- PUNCT B-O
terminal NOUN B-O
fragment NOUN B-O
( PUNCT B-O
GST PROPN B-O
- PUNCT B-O
MYPT1667–1004 PROPN B-O
) PUNCT B-O
was AUX B-O
captured VERB B-O
on ADP B-O
the DET B-O
surface NOUN B-O
. PUNCT B-O

Our PRON B-O
estimates NOUN B-O
( PUNCT B-O
black ADJ B-O
) PUNCT B-O
of ADP B-O
the DET B-O
excess ADJ B-LF
hazard NOUN I-LF
- PUNCT I-LF
months NOUN I-LF
attributable ADJ I-LF
to ADP I-LF
the DET I-LF
acute ADJ I-LF
phase NOUN I-LF
( PUNCT B-O
EHMacute PROPN B-AC
) PUNCT B-O
based VERB B-O
on ADP B-O
( PUNCT B-O
A NOUN B-O
) PUNCT B-O
viral ADJ B-O
load NOUN B-O
trajectories NOUN B-O
( PUNCT B-O
Fig NOUN B-O
. PUNCT B-O

2 NUM B-O
) PUNCT B-O
and CCONJ B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
our PRON B-O
fit NOUN B-O
of ADP B-O
a DET B-O
couples NOUN B-O
transmission NOUN B-O
model NOUN B-O
to ADP B-O
the DET B-O
Rakai PROPN B-O
retrospective ADJ B-O
cohort NOUN B-O
. PUNCT B-O

These PRON B-O
comprise VERB B-O
: PUNCT B-O
release NOUN B-O
from ADP B-O
chaperones NOUN B-O
and CCONJ B-O
co NOUN B-O
- PUNCT B-O
chaperones NOUN B-O
, PUNCT B-O
trimerization NOUN B-O
via ADP B-O
an DET B-O
unmasked ADJ B-O
coiled VERB B-O
- PUNCT B-O
coil NOUN B-O
domain NOUN B-O
, PUNCT B-O
binding NOUN B-O
to ADP B-O
its PRON B-O
cognate NOUN B-O
DNA NOUN B-O
sequences NOUN B-O
in ADP B-O
regulatory ADJ B-O
regions NOUN B-O
of ADP B-O
target NOUN B-O
genes NOUN B-O
, PUNCT B-O
and CCONJ B-O
stimulation NOUN B-O
of ADP B-O
the DET B-O
transactivation NOUN B-O
potential NOUN B-O
via ADP B-O
the DET B-O
calcium NOUN B-LF
/ SYM I-LF
calmodulin NOUN I-LF
- PUNCT I-LF
dependent ADJ I-LF
kinase NOUN I-LF
II NUM I-LF
( PUNCT B-O
CAMKII)-mediated PROPN B-AC
phosphorylation NOUN B-O
of ADP B-O
a DET B-O
serine NOUN B-O
residue NOUN B-O
within ADP B-O
the DET B-O
HSF1 PROPN B-O
regulatory ADJ B-O
domain NOUN B-O
[ PUNCT B-O
38 NUM B-O
] PUNCT B-O
. PUNCT B-O

Patients NOUN B-O
with ADP B-O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
( PUNCT B-O
HCC PROPN B-AC
) PUNCT B-O
submitted VERB B-O
to ADP B-O
orthotopic ADJ B-LF
liver NOUN I-LF
transplantation NOUN I-LF
( PUNCT B-O
OLT PROPN B-AC
) PUNCT B-O
have VERB B-O
a DET B-O
variable ADJ B-O
5 NUM B-O
- PUNCT B-O
year NOUN B-O
survival NOUN B-O
rate NOUN B-O
limited VERB B-O
mostly ADV B-O
by ADP B-O
tumor NOUN B-O
recurrence NOUN B-O
. PUNCT B-O

All DET B-O
data NOUN B-O
in ADP B-O
this DET B-O
study NOUN B-O
are AUX B-O
computed VERB B-O
with ADP B-O
their PRON B-O
95 NUM B-O
% NOUN B-O
uncertainty NOUN B-LF
intervals NOUN I-LF
( PUNCT B-O
UIs PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
13–17 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
oxidative ADJ B-O
fluorescent ADJ B-O
dye NOUN B-O
, PUNCT B-O
DHE PROPN B-AC
, PUNCT B-O
was AUX B-O
freely ADV B-O
permeable ADJ B-O
to ADP B-O
cells NOUN B-O
, PUNCT B-O
and CCONJ B-O
in ADP B-O
the DET B-O
presence NOUN B-O
of ADP B-O
O2- NOUN B-O
was AUX B-O
oxidized VERB B-O
to ADP B-O
ethidium NOUN B-LF
bromide NOUN I-LF
( PUNCT B-O
EtBr PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
was AUX B-O
trapped VERB B-O
by ADP B-O
intercalation NOUN B-O
with ADP B-O
DNA PROPN B-O
. PUNCT B-O

EtBr PROPN B-AC
was AUX B-O
excited VERB B-O
at ADP B-O
488 NUM B-O
nm NOUN B-O
with ADP B-O
an DET B-O
emission NOUN B-O
spectrum NOUN B-O
of ADP B-O
610 NUM B-O
nm NOUN B-O
. PUNCT B-O

The DET B-O
physiological ADJ B-O
factors NOUN B-O
which PRON B-O
affect VERB B-O
left ADJ B-LF
ventricular ADJ I-LF
( PUNCT B-O
LV PROPN B-AC
) PUNCT B-O
long ADJ B-O
- PUNCT B-O
axis NOUN B-O
function NOUN B-O
are AUX B-O
not PART B-O
fully ADV B-O
defined VERB B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
AM PROPN B-AC
, PUNCT B-O
acute ADJ B-LF
malnutrition NOUN I-LF
; PUNCT B-O
BCC PROPN B-AC
, PUNCT B-O
behavior NOUN B-LF
change NOUN I-LF
communication NOUN I-LF
; PUNCT B-O
CMAM PROPN B-AC
, PUNCT B-O
community NOUN B-O
management NOUN B-O
of ADP B-O
AM PROPN B-AC
; PUNCT B-O
CNS PROPN B-AC
, PUNCT B-O
well ADJ B-O
- PUNCT B-O
baby NOUN B-O
consultation NOUN B-O
; PUNCT B-O
MAM PROPN B-AC
, PUNCT B-O
moderate ADJ B-O
AM PROPN B-AC
; PUNCT B-O
MUAC PROPN B-AC
, PUNCT B-O
mid ADJ B-LF
- PUNCT I-LF
upper ADJ I-LF
arm NOUN I-LF
circumference NOUN I-LF
; PUNCT B-O
SAM PROPN B-AC
, PUNCT B-O
severe ADJ B-O
AM PROPN B-AC
; PUNCT B-O
SQ PROPN B-AC
, PUNCT B-O
small ADJ B-O
- PUNCT B-O
quantity NOUN B-O
lipid NOUN B-O
- PUNCT B-O
based VERB B-O
nutrition NOUN B-O
supplement NOUN B-O
; PUNCT B-O
-LNSWLZ PROPN B-AC
, PUNCT B-O
weight NOUN B-LF
- PUNCT I-LF
for ADP I-LF
- PUNCT I-LF
length NOUN I-LF
z NOUN I-LF
- PUNCT I-LF
score NOUN I-LF
A DET B-O
candidate NOUN B-O
target NOUN B-O
pathway NOUN B-O
is AUX B-O
quorum NOUN B-LF
sensing NOUN I-LF
( PUNCT B-O
QS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
many ADJ B-O
bacterial ADJ B-O
pathogens NOUN B-O
use VERB B-O
to PART B-O
coordinately ADV B-O
regulate VERB B-O
virulence NOUN B-O
determinants NOUN B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
understand VERB B-O
how SCONJ B-O
p84 NOUN B-O
could AUX B-O
mask VERB B-O
Ser582 NOUN B-O
phosphorylation NOUN B-O
, PUNCT B-O
and CCONJ B-O
to PART B-O
map VERB B-O
the DET B-O
p110γ NOUN B-O
- PUNCT B-O
p84 NOUN B-O
contact NOUN B-O
interface NOUN B-O
, PUNCT B-O
hydrogen NOUN B-LF
deuterium NOUN I-LF
exchange NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT B-O
HDX-MS PROPN B-AC
) PUNCT B-O
was AUX B-O
used VERB B-O
. PUNCT B-O

In ADP B-O
more ADJ B-O
than ADP B-O
400 NUM B-O
studies NOUN B-O
compiled VERB B-O
in ADP B-O
the DET B-O
GWAS PROPN B-AC
catalog NOUN B-O
[ PUNCT B-O
108 NUM B-O
] PUNCT B-O
, PUNCT B-O
only ADV B-O
a DET B-O
small ADJ B-O
minority NOUN B-O
of ADP B-O
the DET B-O
trait NOUN B-LF
/ SYM I-LF
disease NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
SNPs NOUN I-LF
( PUNCT B-O
TASs PROPN B-AC
) NOUN B-O
occur VERB B-O
in ADP B-O
protein NOUN B-O
- PUNCT B-O
coding VERB B-O
regions NOUN B-O
; PUNCT B-O
the DET B-O
large ADJ B-O
majority NOUN B-O
( PUNCT B-O
89 NUM B-O
% NOUN B-O
) NOUN B-O
are AUX B-O
in ADP B-O
noncoding ADJ B-O
regions NOUN B-O
. PUNCT B-O

Statistical ADJ B-O
comparisons NOUN B-O
were AUX B-O
performed VERB B-O
with ADP B-O
a DET B-O
2 NUM B-O
- PUNCT B-O
way NOUN B-O
ANOVA NOUN B-O
using VERB B-O
time NOUN B-O
and CCONJ B-O
genotype NOUN B-O
as ADP B-O
factors NOUN B-O
, PUNCT B-O
followed VERB B-O
by ADP B-O
post ADJ B-O
hoc ADJ B-O
pairwise ADJ B-O
comparisons NOUN B-O
at ADP B-O
each DET B-O
time NOUN B-O
point NOUN B-O
to ADP B-O
obtain VERB B-O
nominal ADJ B-O
p NOUN B-O
- PUNCT B-O
values NOUN B-O
, PUNCT B-O
which PRON B-O
were AUX B-O
subjected VERB B-O
to ADP B-O
a DET B-O
Tukey PROPN B-O
correction NOUN B-O
for ADP B-O
multiple ADJ B-O
comparisons NOUN B-O
( PUNCT B-O
S1 PROPN B-O
Data PROPN B-O
, PUNCT B-O
Sheet PROPN B-O
1 NUM B-O
G PROPN B-O
) PUNCT B-O
. PUNCT B-O

AMPK PROPN B-AC
, PUNCT B-O
adenosine NOUN B-LF
monophosphate NOUN I-LF
regulated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
; PUNCT B-O
DTS PROPN B-AC
, PUNCT B-O
developmentally ADV B-LF
timed VERB I-LF
sleep NOUN I-LF
; PUNCT B-O
L1 PROPN B-AC
stage NOUN B-O
, PUNCT B-O
first ADJ B-LF
larval ADJ I-LF
stage NOUN I-LF
; PUNCT B-O
ns PROPN B-AC
, PUNCT B-O
not PART B-LF
significant ADJ I-LF
; PUNCT B-O
p PROPN B-AC
-AMPK PROPN B-AC
, PUNCT B-O
phosphorylated VERB B-LF
AMPK NOUN I-LF
AMPK PROPN B-AC
; PUNCT B-O
SIS PROPN B-AC
, PUNCT B-O
stress NOUN B-LF
- PUNCT I-LF
induced VERB I-LF
sleep NOUN I-LF
; PUNCT B-O
UVC PROPN B-AC
, PUNCT B-O
ultraviolet ADJ B-LF
C NOUN I-LF
; PUNCT B-O
WT PROPN B-O
, PUNCT B-O
wild ADJ B-O
type NOUN B-O
. PUNCT B-O

Logistic ADJ B-O
regression NOUN B-O
analysis NOUN B-O
showed VERB B-O
that SCONJ B-O
the DET B-O
independent ADJ B-O
factors NOUN B-O
associated VERB B-O
with ADP B-O
mortality NOUN B-O
were AUX B-O
postoperative ADJ B-O
lactate ADJ B-O
level NOUN B-O
( PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
[ X B-O
OR PROPN B-AC
] X B-O
1.926 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
[ X B-O
CI PROPN B-AC
] X B-O
1.101–3.089 NUM B-O
, PUNCT B-O
p NOUN B-O
= SYM B-O
0.007 NUM B-O
) PUNCT B-O
, PUNCT B-O
postoperative ADJ B-O
sequential ADJ B-O
organ NOUN B-O
failure NOUN B-O
assessment NOUN B-O
score NOUN B-O
( PUNCT B-O
OR PROPN B-AC
1.593 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
1.160–2.187 NUM B-O
, PUNCT B-O
p NOUN B-O
= SYM B-O
0.004 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
DNI PROPN B-AC
on ADP B-O
POD1 PROPN B-O
( PUNCT B-O
OR PROPN B-AC
1.118 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
1.028–1.215 NUM B-O
, PUNCT B-O
p NOUN B-O
= SYM B-O
0.009 NUM B-O
) PUNCT B-O
. PUNCT B-O

Missing VERB B-O
values NOUN B-O
in ADP B-O
NSDUH PROPN B-AC
are AUX B-O
imputed VERB B-O
by ADP B-O
SAMHSA PROPN B-AC
prior ADV B-O
to ADP B-O
release NOUN B-O
of ADP B-O
the DET B-O
dataset NOUN B-O
using VERB B-O
a DET B-O
predictive ADJ B-LF
mean ADJ I-LF
neighborhood NOUN I-LF
( PUNCT B-O
PMN PROPN B-AC
) PUNCT B-O
and CCONJ B-O
a DET B-O
modified VERB B-O
PMN PROPN B-AC
as SCONJ B-O
detailed VERB B-O
in ADP B-O
the DET B-O
NSDUH PROPN B-AC
codebook NOUN B-O
[ PUNCT B-O
26 NUM B-O
] PUNCT B-O
. PUNCT B-O

Mutation NOUN B-O
of ADP B-O
serine NOUN B-LF
( PUNCT B-O
S PROPN B-AC
) PUNCT B-O
424 NUM B-O
to ADP B-O
alanine NOUN B-LF
( PUNCT B-O
A PROPN B-AC
) PUNCT B-O
( PUNCT B-O
mimics NOUN B-O
dephosphorylation NOUN B-O
) PUNCT B-O
inhibits VERB B-O
HDAC3 PROPN B-AC
enzyme NOUN B-O
activity NOUN B-O
without ADP B-O
affecting VERB B-O
its PRON B-O
expression NOUN B-O
or CCONJ B-O
subcellular ADJ B-O
localization NOUN B-O
[ PUNCT B-O
38 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
data NOUN B-O
from ADP B-O
the DET B-O
fatty ADJ B-O
acid NOUN B-O
compositions NOUN B-O
were AUX B-O
used VERB B-O
to ADP B-O
investigate VERB B-O
the DET B-O
nutritional ADJ B-O
lipid NOUN B-O
quality NOUN B-O
indices NOUN B-O
from ADP B-O
the DET B-O
five NUM B-O
evaluated VERB B-O
freshwater NOUN B-O
fish NOUN B-O
species NOUN B-O
through ADP B-O
three NUM B-O
important ADJ B-O
indicators NOUN B-O
, PUNCT B-O
namely ADV B-O
, PUNCT B-O
index NOUN B-LF
of ADP I-LF
atherogenicity NOUN I-LF
( PUNCT B-O
IA PROPN B-AC
) X B-O
and CCONJ B-O
index NOUN B-LF
of ADP I-LF
thrombogenicity NOUN I-LF
( PUNCT B-O
IT PROPN B-AC
) X B-O
, PUNCT B-O
according VERB B-O
to ADP B-O
Ulbricht PROPN B-O
and CCONJ B-O
Southgate PROPN B-O
[ X B-O
37 NUM B-O
] PUNCT B-O
with ADP B-O
modifications NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
hypocholesterolemic ADJ B-LF
/ SYM I-LF
hypercholesterolemic ADJ I-LF
ratio NOUN I-LF
( PUNCT B-O
h PROPN B-AC
) X B-O
according VERB B-O
to ADP B-O
Santos PROPN B-O
- PUNCT B-O
Silva PROPN B-O
, PUNCT B-O
Bessa PROPN B-O
, PUNCT B-O
and CCONJ B-O
Santos PROPN B-O
- PUNCT B-O
Silva PROPN B-O
[ X B-O
38 NUM B-O
] PUNCT B-O
, PUNCT B-O
as SCONJ B-O
follows VERB B-O
: PUNCT B-O
/HIA=(4×C14:0+C16:0)/(∑MUFA+∑(n–6)+∑(n–3))IT=(C14:0+C16:0+C18:0)/(0.5×∑MUFA+0.5×∑(n–6)+3×∑(n–3)+100×∑(n–3)/∑(n–6))h PROPN B-AC
+ X B-O
16:0 NUM B-O
) X B-O
A DET B-O
retrospective ADJ B-O
cross ADJ B-O
- ADJ B-O
sectional ADJ B-O
study NOUN B-O
was AUX B-O
conducted VERB B-O
on ADP B-O
medical ADJ B-O
records NOUN B-O
of ADP B-O
patients NOUN B-O
admitted VERB B-O
from ADP B-O
August PROPN B-O
1 NUM B-O
, PUNCT B-O
2013‒July NUM B-O
31 NUM B-O
, PUNCT B-O
2018 NUM B-O
in ADP B-O
Ayder PROPN B-LF
Comprehensive PROPN I-LF
Specialized PROPN I-LF
Hospital PROPN I-LF
( PUNCT B-O
ACSH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
found VERB B-O
in ADP B-O
Mekelle PROPN B-O
, PUNCT B-O
the DET B-O
capital NOUN B-O
city NOUN B-O
of ADP B-O
Tigray PROPN B-O
regional ADJ B-O
state NOUN B-O
, PUNCT B-O
783 NUM B-O
Kilometers NOUN B-O
away ADV B-O
from ADP B-O
Addis PROPN B-O
Ababa PROPN B-O
, PUNCT B-O
Ethiopia PROPN B-O
. PUNCT B-O

U2OS PROPN B-O
reporter NOUN B-O
cell NOUN B-O
lines NOUN B-O
specifically ADV B-O
designed VERB B-O
to PART B-O
repair NOUN B-O
DNA NOUN B-O
damage NOUN B-O
through ADP B-O
nonhomologous ADJ B-LF
end NOUN I-LF
joining NOUN I-LF
( PUNCT B-O
NHEJ PROPN B-AC
) PUNCT B-O
and CCONJ B-O
homology NOUN B-LF
- PUNCT I-LF
directed VERB I-LF
repair NOUN I-LF
( PUNCT B-O
HDR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
were AUX B-O
transfected VERB B-O
with ADP B-O
nonspecific ADJ B-O
control NOUN B-O
( PUNCT B-O
si PROPN B-AC
) PUNCT B-O
or CCONJ B-O
-NCSam68 PROPN B-AC
- PUNCT B-O
specific ADJ B-O
( PUNCT B-O
si NOUN B-O
- PUNCT B-O
Sam68 PROPN B-AC
) PUNCT B-O
small ADJ B-O
interference NOUN B-O
RNA NOUN B-O
, PUNCT B-O
together ADV B-O
with ADP B-O
( PUNCT B-O
+ PUNCT B-O
) PUNCT B-O
or CCONJ B-O
without ADP B-O
( PUNCT B-O
− PUNCT B-O
) PUNCT B-O
I NOUN B-O
- PUNCT B-O
SceI PROPN B-O
plasmid NOUN B-O
, PUNCT B-O
or CCONJ B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
GFP PROPN B-AC
) PUNCT B-O
control NOUN B-O
. PUNCT B-O

The DET B-O
carboxysome NOUN B-O
is AUX B-O
a DET B-O
bacterial ADJ B-O
organelle NOUN B-O
that PRON B-O
functions VERB B-O
to PART B-O
enhance VERB B-O
the DET B-O
efficiency NOUN B-O
of ADP B-O
CO2 NOUN B-O
fixation NOUN B-O
by ADP B-O
encapsulating VERB B-O
the DET B-O
enzymes NOUN B-O
ribulose NOUN B-LF
bisphosphate NOUN I-LF
carboxylase NOUN I-LF
/ SYM I-LF
oxygenase NOUN I-LF
( PUNCT B-O
RuBisCO PROPN B-AC
) PUNCT B-O
and CCONJ B-O
carbonic ADJ B-O
anhydrase NOUN B-O
. PUNCT B-O

The DET B-O
following ADJ B-O
ELISA PROPN B-O
kits NOUN B-O
were AUX B-O
used VERB B-O
: PUNCT B-O
LRG1 PROPN B-AC
ELISA PROPN B-O
kit NOUN B-O
( PUNCT B-O
Cosmic PROPN B-O
Corporation PROPN B-O
, PUNCT B-O
Tokyo PROPN B-O
, PUNCT B-O
Japan PROPN B-O
, PUNCT B-O
product NOUN B-O
number NOUN B-O
; PUNCT B-O
T131C100 NUM B-O
) PUNCT B-O
and CCONJ B-O
Human PROPN B-O
Total PROPN B-O
Angiotensinogen PROPN B-LF
( PUNCT B-O
AGT PROPN B-AC
) PUNCT B-O
Assay PROPN B-O
Kit PROPN B-O
( PUNCT B-O
Immuno PROPN B-O
- PUNCT B-O
Biological PROPN B-O
Laboratories PROPN B-O
, PUNCT B-O
Gunma PROPN B-O
, PUNCT B-O
Japan PROPN B-O
, PUNCT B-O
product NOUN B-O
number NOUN B-O
; PUNCT B-O
27412 NUM B-O
) PUNCT B-O
. PUNCT B-O

We PRON B-O
prospectively ADV B-O
collected VERB B-O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT B-O
PBMCs PROPN B-AC
) PUNCT B-O
by ADP B-O
leukapheresis NOUN B-O
from ADP B-O
a DET B-O
55 NUM B-O
- PUNCT B-O
year NOUN B-O
- PUNCT B-O
old ADJ B-O
man NOUN B-O
with ADP B-O
chronic ADJ B-O
HIV PROPN B-O
infection NOUN B-O
before ADP B-O
and CCONJ B-O
after ADP B-O
allo-SCT PROPN B-AC
to PART B-O
measure VERB B-O
the DET B-O
size NOUN B-O
of ADP B-O
the DET B-O
HIV-1 PROPN B-O
reservoir NOUN B-O
and CCONJ B-O
characterize VERB B-O
viral ADJ B-O
phylogeny NOUN B-O
and CCONJ B-O
phenotypic ADJ B-O
changes NOUN B-O
in ADP B-O
immune ADJ B-O
cells NOUN B-O
. PUNCT B-O

Outcome NOUN B-O
measures NOUN B-O
were AUX B-O
deaths NOUN B-O
, PUNCT B-O
along ADP B-O
with ADP B-O
nonfatal ADJ B-O
myocardial ADJ B-LF
infarction NOUN I-LF
( PUNCT B-O
MI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
stroke NOUN B-O
, PUNCT B-O
congestive ADJ B-LF
heart NOUN I-LF
failure NOUN I-LF
( PUNCT B-O
CHF PROPN B-AC
) PUNCT B-O
, PUNCT B-O
transient ADJ B-LF
ischemic ADJ I-LF
attack NOUN I-LF
( PUNCT B-O
TIA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
antihypertensive ADJ B-O
treatment NOUN B-O
recorded VERB B-O
from ADP B-O
structured VERB B-O
interviews NOUN B-O
at ADP B-O
scheduled VERB B-O
intervals NOUN B-O
. PUNCT B-O

At ADP B-O
GW PROPN B-O
15–26 NUM B-O
, PUNCT B-O
a DET B-O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT B-O
SD PROPN B-AC
) PUNCT B-O
increase NOUN B-O
in ADP B-O
total ADJ B-O
n-3 NOUN B-O
PUFAs PROPN B-AC
and CCONJ B-O
individual ADJ B-O
n-3 NOUN B-O
DPA PROPN B-AC
was AUX B-O
associated VERB B-O
with ADP B-O
a DET B-O
36 NUM B-O
% NOUN B-O
( PUNCT B-O
adjusted VERB B-O
odds NOUN B-O
ratio NOUN B-O
0.64 NUM B-O
; PUNCT B-O
95 NUM B-O
% NOUN B-O
CI NOUN B-O
0.42–0.96 NUM B-O
; PUNCT B-O
P NOUN B-O
= SYM B-O
0.042 NUM B-O
) PUNCT B-O
and CCONJ B-O
33 NUM B-O
% NOUN B-O
( PUNCT B-O
0.67 NUM B-O
; PUNCT B-O
95 NUM B-O
% NOUN B-O
CI NOUN B-O
0.45–0.99 NUM B-O
; PUNCT B-O
P NOUN B-O
= SYM B-O
0.047 NUM B-O
) PUNCT B-O
lower ADJ B-O
risk NOUN B-O
of ADP B-O
GDM PROPN B-AC
, PUNCT B-O
respectively ADV B-O
; PUNCT B-O
however ADV B-O
, PUNCT B-O
the DET B-O
significance NOUN B-O
did AUX B-O
not PART B-O
persist VERB B-O
after ADP B-O
post X B-O
hoc X B-O
false ADJ B-O
- PUNCT B-O
discovery NOUN B-O
rate NOUN B-O
( PUNCT B-O
FDR PROPN B-AC
) PUNCT B-O
correction NOUN B-O
( PUNCT B-O
FDR PROPN B-AC
- PUNCT B-O
corrected VERB B-O
P NOUN B-O
values NOUN B-O
> SYM B-O
0.05 NUM B-O
) PUNCT B-O
. PUNCT B-O

Terminal ADJ B-O
hypertrophic ADJ B-O
differentiation NOUN B-O
is AUX B-O
accompanied VERB B-O
by ADP B-O
a DET B-O
massive ADJ B-O
increase NOUN B-O
in ADP B-O
cell NOUN B-O
volume NOUN B-O
and CCONJ B-O
expression NOUN B-O
of ADP B-O
alkaline ADJ B-LF
phosphatase NOUN I-LF
( PUNCT B-O
ALP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
an DET B-O
enzyme NOUN B-O
required VERB B-O
for ADP B-O
mineralization NOUN B-O
of ADP B-O
cartilage NOUN B-O
[ PUNCT B-O
20 NUM B-O
] PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
the DET B-O
first ADJ B-O
step NOUN B-O
in ADP B-O
cartilage NOUN B-O
remodeling NOUN B-O
. PUNCT B-O

We PRON B-O
next ADV B-O
asked VERB B-O
whether SCONJ B-O
the DET B-O
surface NOUN B-O
polarization NOUN B-O
of ADP B-O
other ADJ B-O
axonal ADJ B-O
membrane NOUN B-O
proteins NOUN B-O
was AUX B-O
affected VERB B-O
in ADP B-O
the DET B-O
absence NOUN B-O
of ADP B-O
SorCS1 PROPN B-AC
. PUNCT B-O

The DET B-O
cell NOUN B-O
adhesion NOUN B-O
molecules NOUN B-O
neuron NOUN B-LF
- PUNCT I-LF
glia NOUN I-LF
cell NOUN I-LF
adhesion NOUN I-LF
molecule NOUN I-LF
L1 NOUN I-LF
( PUNCT B-O
L1/NgCAM PROPN B-AC
) PUNCT B-O
and CCONJ B-O
contactin NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
2 NUM I-LF
( PUNCT B-O
Caspr2 PROPN B-AC
) PUNCT B-O
are AUX B-O
both PRON B-O
targeted VERB B-O
to ADP B-O
the DET B-O
axonal ADJ B-O
surface NOUN B-O
but CCONJ B-O
via ADP B-O
distinct ADJ B-O
trafficking NOUN B-O
routes NOUN B-O
. PUNCT B-O

These DET B-O
CRMs PROPN B-AC
act VERB B-O
as ADP B-O
neurogenic ADJ B-LF
ectoderm NOUN I-LF
enhancers NOUN I-LF
( PUNCT B-O
NEEs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
function VERB B-O
to PART B-O
drive VERB B-O
gene NOUN B-O
expression NOUN B-O
in ADP B-O
the DET B-O
early ADJ B-O
embryonic ADJ B-O
neuroectoderm NOUN B-O
before SCONJ B-O
gastrulation NOUN B-O
has AUX B-O
commenced VERB B-O
[ PUNCT B-O
36 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
autoxidation NOUN B-O
of ADP B-O
intracellular ADJ B-O
oxyHb NOUN B-O
and CCONJ B-O
downstream ADJ B-O
free ADJ B-O
radical NOUN B-O
formation NOUN B-O
is AUX B-O
prevented VERB B-O
mainly ADV B-O
by ADP B-O
superoxide NOUN B-LF
dismutase NOUN I-LF
( PUNCT B-O
SOD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
catalase NOUN B-O
and CCONJ B-O
glutathione NOUN B-LF
peroxidase NOUN I-LF
( PUNCT B-O
GPx PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
18,19 NUM B-O
] PUNCT B-O
. PUNCT B-O

This DET B-O
paper NOUN B-O
examines VERB B-O
whether SCONJ B-O
practices NOUN B-O
regarding VERB B-O
consent NOUN B-O
, PUNCT B-O
confidentiality NOUN B-O
, PUNCT B-O
and CCONJ B-O
referral NOUN B-O
vary VERB B-O
depending VERB B-O
on ADP B-O
whether SCONJ B-O
testing NOUN B-O
is AUX B-O
provided VERB B-O
through ADP B-O
voluntary ADJ B-LF
counseling NOUN I-LF
and CCONJ I-LF
testing NOUN I-LF
( PUNCT B-O
VCT PROPN B-AC
) PUNCT B-O
or CCONJ B-O
provider NOUN B-O
- PUNCT B-O
initiated VERB B-O
testing NOUN B-O
. PUNCT B-O

Mice NOUN B-O
that PRON B-O
need VERB B-O
to ADP B-O
be AUX B-O
perfused VERB B-O
with ADP B-O
PBS PROPN B-AC
and/or CCONJ B-O
4 NUM B-O
% NOUN B-O
paraformaldehyde NOUN B-LF
( PUNCT B-O
PFA PROPN B-AC
) PUNCT B-O
prior ADV B-O
to ADP B-O
tissue NOUN B-O
harvest NOUN B-O
were AUX B-O
anesthetized VERB B-O
with ADP B-O
a DET B-O
combination NOUN B-O
of ADP B-O
ketamine NOUN B-O
( PUNCT B-O
20 NUM B-O
mg NOUN B-O
/ SYM B-O
kg NOUN B-O
body NOUN B-O
weight NOUN B-O
) PUNCT B-O
and CCONJ B-O
xylazine NOUN B-O
( PUNCT B-O
2 NUM B-O
mg NOUN B-O
/ SYM B-O
kg NOUN B-O
body NOUN B-O
weight NOUN B-O
) PUNCT B-O
. PUNCT B-O

Mild ADJ B-LF
cognitive ADJ I-LF
impairment NOUN I-LF
( PUNCT B-O
MCI PROPN B-AC
) PUNCT B-O
refers VERB B-O
to ADP B-O
a DET B-O
transitional ADJ B-O
zone NOUN B-O
between ADP B-O
normal ADJ B-O
ageing NOUN B-O
and CCONJ B-O
dementia NOUN B-O
. PUNCT B-O

Quantitative ADJ B-O
data NOUN B-O
were AUX B-O
to ADP B-O
analyze VERB B-O
completeness NOUN B-O
and CCONJ B-O
timeliness NOUN B-O
of ADP B-O
surveillance NOUN B-O
system NOUN B-O
performance NOUN B-O
from ADP B-O
national ADJ B-O
District PROPN B-LF
Health PROPN I-LF
Information PROPN I-LF
System PROPN I-LF
2 NUM I-LF
( PUNCT B-O
DHIS2 PROPN B-AC
) PUNCT B-O
during ADP B-O
October PROPN B-O
2014 NUM B-O
to ADP B-O
September PROPN B-O
2016 NUM B-O
. PUNCT B-O

Importantly ADV B-O
, PUNCT B-O
the DET B-O
mice NOUN B-O
are AUX B-O
resistant ADJ B-O
to ADP B-O
the DET B-O
autoimmune ADJ B-O
disease NOUN B-O
models NOUN B-O
collagen NOUN B-O
- PUNCT B-O
induced VERB B-O
arthritis NOUN B-O
and CCONJ B-O
experimental ADJ B-LF
autoimmune ADJ I-LF
encephalomyelitis NOUN I-LF
( PUNCT B-O
EAE PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
20 NUM B-O
] PUNCT B-O
, PUNCT B-O
have VERB B-O
less ADV B-O
aggressive ADJ B-O
Kras PROPN B-O
- PUNCT B-O
induced VERB B-O
inflammatory ADJ B-O
pancreatic ADJ B-O
cancer NOUN B-O
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
fail VERB B-O
to ADP B-O
mount VERB B-O
an DET B-O
effective ADJ B-O
IL-17A PROPN B-AC
- PUNCT B-O
dependent ADJ B-O
immune ADJ B-O
response NOUN B-O
to ADP B-O
Citrobacter PROPN B-O
rodentium NOUN B-O
infection NOUN B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
surgically ADV B-O
removed VERB B-O
tissue NOUN B-O
was AUX B-O
cut VERB B-O
to PART B-O
smaller ADJ B-O
pieces NOUN B-O
with ADP B-O
scissors NOUN B-O
under ADP B-O
sterile ADJ B-O
conditions NOUN B-O
, PUNCT B-O
and CCONJ B-O
then ADV B-O
incubated VERB B-O
for ADP B-O
15 NUM B-O
min NOUN B-O
at ADP B-O
room NOUN B-LF
temperature NOUN I-LF
( PUNCT B-O
RT PROPN B-AC
) PUNCT B-O
in ADP B-O
dithiothreitol PROPN B-O
: PUNCT B-O
Hank´s PART B-O
balanced ADJ B-O
salt NOUN B-O
solution NOUN B-O
( PUNCT B-O
HBSS PROPN B-O
) PUNCT B-O
( PUNCT B-O
Biosera PROPN B-O
, PUNCT B-O
Nuaille PROPN B-O
, PUNCT B-O
France PROPN B-O
) PUNCT B-O
mix NOUN B-O
( PUNCT B-O
1:9 NUM B-O
v NOUN B-O
/ SYM B-O
v NOUN B-O
) PUNCT B-O
, PUNCT B-O
in ADP B-O
order NOUN B-O
to PART B-O
remove VERB B-O
potential ADJ B-O
contamination NOUN B-O
. PUNCT B-O

OR PROPN B-AC
, PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
ref NOUN B-O
. PUNCT B-O

, PUNCT B-O
reference NOUN B-O
; PUNCT B-O
R1 NOUN B-O
, PUNCT B-O
positive ADJ B-O
; PUNCT B-O
R0 NOUN B-O
, PUNCT B-O
negative ADJ B-O
resection NOUN B-O
margins NOUN B-O
Malondialdehyde NOUN B-LF
acetaldehyde NOUN I-LF
- PUNCT B-O
modified VERB B-O
LDL PROPN B-AC
( PUNCT B-O
MAA PROPN B-AC
- PUNCT B-O
LDL PROPN B-AC
) PUNCT B-O
and CCONJ B-O
copper NOUN B-O
- PUNCT B-O
oxidized VERB B-O
LDL PROPN B-AC
( PUNCT B-O
CuOx-LDL PROPN B-AC
) PUNCT B-O
were AUX B-O
prepared VERB B-O
as SCONJ B-O
described VERB B-O
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

Then ADV B-O
, PUNCT B-O
the DET B-O
specimens NOUN B-O
were AUX B-O
washed VERB B-O
twice ADV B-O
with ADP B-O
stain NOUN B-O
buffer NOUN B-O
and CCONJ B-O
subsequently ADV B-O
mounted VERB B-O
with ADP B-O
fluoroGel PROPN B-O
mounting NOUN B-O
medium NOUN B-O
( PUNCT B-O
GeneTex PROPN B-O
, PUNCT B-O
Inc PROPN B-O
, PUNCT B-O
Irvine PROPN B-O
, PUNCT B-O
CA PROPN B-O
) PUNCT B-O
. PUNCT B-O

Stained VERB B-O
specimens NOUN B-O
were AUX B-O
examined VERB B-O
and CCONJ B-O
captured VERB B-O
with ADP B-O
Leica PROPN B-O
TCS PROPN B-O
SPII PROPN B-O
confocal ADJ B-LF
laser NOUN I-LF
scanning VERB I-LF
microscopy NOUN I-LF
system NOUN B-O
( PUNCT B-O
CLSM PROPN B-AC
, PUNCT B-O
; PUNCT B-O
Leica PROPN B-O
Microsystem PROPN B-O
, PUNCT B-O
GmbH PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
with ADP B-O
LAS PROPN B-O
AF PROPN B-O
Lite PROPN B-O
software NOUN B-O
( PUNCT B-O
Leica PROPN B-O
Microsystems PROPN B-O
, PUNCT B-O
Mannheim PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
. PUNCT B-O

HEK PROPN B-AC
, PUNCT B-O
human ADJ B-LF
embryonic ADJ I-LF
kidney NOUN I-LF
cell NOUN I-LF
; PUNCT B-O
ns PROPN B-O
, PUNCT B-O
not PART B-O
significant ADJ B-O
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
type NOUN I-LF
. PUNCT B-O

Malondialdehyde NOUN B-LF
( PUNCT B-O
MDA PROPN B-AC
) PUNCT B-O
content NOUN B-O
was AUX B-O
measured VERB B-O
by ADP B-O
the DET B-O
procedures NOUN B-O
described VERB B-O
by ADP B-O
Wang PROPN B-O
et PROPN B-O
al NOUN B-O
. PUNCT B-O

[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

Ischaemia NOUN B-O
- PUNCT B-O
reperfusion NOUN B-O
injury NOUN B-O
in ADP B-O
kidney NOUN B-O
transplantation NOUN B-O
leads VERB B-O
to ADP B-O
delayed VERB B-LF
graft NOUN I-LF
function NOUN I-LF
( PUNCT B-O
DGF PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
associated VERB B-O
with ADP B-O
reduced VERB B-O
long ADJ B-O
term NOUN B-O
graft NOUN B-O
function NOUN B-O
. PUNCT B-O

Opaque NOUN B-O
a DET B-O
and CCONJ B-O
α PUNCT B-O
cells NOUN B-O
secrete VERB B-O
a DET B-O
sex NOUN B-O
- PUNCT B-O
specific ADJ B-O
pheromone NOUN B-O
and CCONJ B-O
induce VERB B-O
the DET B-O
formation NOUN B-O
of ADP B-O
mating NOUN B-O
projections NOUN B-O
in ADP B-O
cells NOUN B-O
with ADP B-O
an DET B-O
opposite ADJ B-O
Mating NOUN B-LF
type NOUN I-LF
locus NOUN I-LF
( PUNCT B-O
MTL PROPN B-AC
) PUNCT B-O
type NOUN B-O
, PUNCT B-O
thus ADV B-O
initiating VERB B-O
cell NOUN B-O
fusion NOUN B-O
and CCONJ B-O
mating NOUN B-O
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

Heart NOUN B-LF
rate NOUN I-LF
( PUNCT B-O
HR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
velocity NOUN B-O
, PUNCT B-O
left ADJ B-LF
ventricle NOUN I-LF
( PUNCT B-O
LV PROPN B-AC
) PUNCT B-O
mass NOUN B-O
, PUNCT B-O
LV PROPN B-LF
internal ADJ I-LF
LV PROPN B-AC
diameter NOUN I-LF
at ADP I-LF
end NOUN I-LF
- PUNCT I-LF
diastole NOUN I-LF
( PUNCT B-O
LVID PROPN B-AC
) PUNCT B-O
, PUNCT B-O
LV PROPN B-LF
posterior ADJ I-LF
,dLV PROPN B-AC
wall NOUN I-LF
thickness NOUN I-LF
at ADP I-LF
end NOUN I-LF
- PUNCT I-LF
diastole NOUN I-LF
( PUNCT B-O
LVPW PROPN B-AC
) PUNCT B-O
, PUNCT B-O
LV PROPN B-LF
anterior ADJ I-LF
,dLV PROPN B-AC
wall NOUN I-LF
thickness NOUN I-LF
at ADP I-LF
end NOUN I-LF
- PUNCT I-LF
diastole NOUN I-LF
( PUNCT B-O
LVAW PROPN B-AC
) PUNCT B-O
, PUNCT B-O
ejection NOUN B-LF
fraction NOUN I-LF
( PUNCT B-O
,dEF PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
fractional ADJ B-LF
shortening NOUN I-LF
( PUNCT B-O
FS PROPN B-AC
) PUNCT B-O
of ADP B-O
the DET B-O
LV PROPN B-AC
were AUX B-O
measured VERB B-O
. PUNCT B-O

The DET B-O
generation NOUN B-O
of ADP B-O
type NOUN B-LF
2 NUM I-LF
( PUNCT B-O
Th2 PROPN B-AC
) PUNCT B-O
cytokines NOUN B-O
, PUNCT B-O
particularly ADV B-O
interleukins NOUN B-LF
( PUNCT B-O
IL)-13 PROPN B-AC
and CCONJ B-O
IL-4 PROPN B-AC
, PUNCT B-O
is AUX B-O
associated VERB B-O
with ADP B-O
parasite NOUN B-O
expulsion NOUN B-O
through ADP B-O
increased VERB B-O
epithelial ADJ B-O
cell NOUN B-O
turnover NOUN B-O
, PUNCT B-O
mucus NOUN B-O
production NOUN B-O
, PUNCT B-O
and CCONJ B-O
muscle NOUN B-O
hypercontractility NOUN B-O
[ PUNCT B-O
28 NUM B-O
] PUNCT B-O
. PUNCT B-O

Photographs NOUN B-O
showing VERB B-O
double ADJ B-O
- PUNCT B-O
labeling NOUN B-O
for ADP B-O
galanin NOUN B-LF
receptor NOUN I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT B-O
GalR2 PROPN B-AC
) PUNCT B-O
( PUNCT B-O
A PROPN B-O
, PUNCT B-O
D PROPN B-O
) PUNCT B-O
, PUNCT B-O
NF200 PROPN B-O
( PUNCT B-O
B NOUN B-O
, PUNCT B-O
E NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
merged VERB B-O
images NOUN B-O
( PUNCT B-O
C PROPN B-O
, PUNCT B-O
F PROPN B-O
) PUNCT B-O
in ADP B-O
dorsal ADJ B-LF
root NOUN I-LF
ganglion NOUN I-LF
( PUNCT B-O
DRG PROPN B-AC
) PUNCT B-O
neurons NOUN B-O
of ADP B-O
the DET B-O
naïve ADJ B-O
( PUNCT B-O
A PROPN B-O
- PUNCT B-O
C PROPN B-O
) PUNCT B-O
and CCONJ B-O
chronic ADJ B-O
constriction NOUN B-O
injury NOUN B-O
1 NUM B-O
week NOUN B-O
( PUNCT B-O
CCI1W PROPN B-O
) PUNCT B-O
( PUNCT B-O
D PROPN B-O
- PUNCT B-O
F PROPN B-O
) PUNCT B-O
groups NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
PRS PROPN B-AC
, PUNCT B-O
postreperfusion NOUN B-LF
syndrome NOUN I-LF
; PUNCT B-O
PS PROPN B-O
, PUNCT B-O
propensity NOUN B-O
score NOUN B-O
. PUNCT B-O

ABR PROPN B-AC
, PUNCT B-O
auditory ADJ B-LF
brainstem NOUN I-LF
response NOUN I-LF
; PUNCT B-O
DFNA PROPN B-O
, PUNCT B-O
non ADJ B-O
- ADJ B-O
syndromic ADJ B-O
deafness NOUN B-O
with ADP B-O
dominant ADJ B-O
inheritance NOUN B-O
; PUNCT B-O
DFNB PROPN B-O
, PUNCT B-O
non ADJ B-O
- ADJ B-O
syndromic ADJ B-O
deafness NOUN B-O
with ADP B-O
recessive ADJ B-O
inheritance NOUN B-O
; PUNCT B-O
DFNX PROPN B-O
, PUNCT B-O
non ADJ B-O
- ADJ B-O
syndromic ADJ B-O
deafness NOUN B-O
with ADP B-O
X NOUN B-O
- ADJ B-O
linked VERB B-O
inheritance NOUN B-O
; PUNCT B-O
Hemi PROPN B-O
, PUNCT B-O
hemizygote NOUN B-O
; PUNCT B-O
Het PROPN B-O
, PUNCT B-O
heterozygote NOUN B-O
; PUNCT B-O
Hom PROPN B-O
, PUNCT B-O
homozygote NOUN B-O
; PUNCT B-O
MGP PROPN B-AC
, PUNCT B-O
Mouse PROPN B-LF
Genetics PROPN I-LF
Project PROPN I-LF
; PUNCT B-O
tm PROPN B-AC
, PUNCT B-O
targeted VERB B-LF
mutation NOUN I-LF
. PUNCT B-O

Phosphatidylcholine NOUN B-O
( PUNCT B-O
PC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
phosphatidic NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
PA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
cholesterol NOUN B-O
( PUNCT B-O
CH NOUN B-O
) PUNCT B-O
( PUNCT B-O
Avanti PROPN B-O
Polar PROPN B-O
Lipids PROPN B-O
, PUNCT B-O
Alabaster PROPN B-O
, PUNCT B-O
AL PROPN B-O
) PUNCT B-O
were AUX B-O
dissolved VERB B-O
in ADP B-O
chloroform NOUN B-O
under ADP B-O
argon NOUN B-O
, PUNCT B-O
mixed VERB B-O
in ADP B-O
3:1:1 NUM B-O
proportion NOUN B-O
, PUNCT B-O
respectively ADV B-O
( PUNCT B-O
w NOUN B-O
/ SYM B-O
w NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
chloroform NOUN B-O
was AUX B-O
evaporated VERB B-O
. PUNCT B-O

Prior ADV B-O
to ADP B-O
data NOUN B-O
collection NOUN B-O
, PUNCT B-O
a DET B-O
two NUM B-O
- NOUN B-O
day NOUN B-O
intensive ADJ B-O
training NOUN B-O
was AUX B-O
given VERB B-O
to ADP B-O
data NOUN B-O
collectors NOUN B-O
( PUNCT B-O
physiotherapist NOUN B-O
) PUNCT B-O
by ADP B-O
the DET B-O
principal ADJ B-O
investigator NOUN B-O
( PUNCT B-O
KS PROPN B-O
) PUNCT B-O
and CCONJ B-O
clinical ADJ B-O
neurologist NOUN B-O
of ADP B-O
UOGH PROPN B-O
following VERB B-O
which PRON B-O
a DET B-O
pre NOUN B-O
- NOUN B-O
test NOUN B-O
of ADP B-O
data NOUN B-O
collection NOUN B-O
was AUX B-O
carried VERB B-O
out ADP B-O
with ADP B-O
15 NUM B-O
PLHIV PROPN B-AC
. PUNCT B-O

Brief ADJ B-O
peripheral ADJ B-O
neuropathy NOUN B-O
screening NOUN B-O
tool NOUN B-O
validated VERB B-O
by ADP B-O
the DET B-O
AIDS PROPN B-LF
Clinical PROPN I-LF
trial PROPN I-LF
Group PROPN I-LF
( PUNCT B-O
ACTG PROPN B-AC
) PUNCT B-O
[ X B-O
20 X B-O
] X B-O
was AUX B-O
administered VERB B-O
by ADP B-O
a DET B-O
trained VERB B-O
physiotherapist NOUN B-O
. PUNCT B-O

The DET B-O
objective NOUN B-O
of ADP B-O
this DET B-O
study NOUN B-O
was AUX B-O
to ADP B-O
assess VERB B-O
whether SCONJ B-O
SAM PROPN B-AC
treatment NOUN B-O
delivered VERB B-O
by ADP B-O
CHWs PROPN B-AC
close ADJ B-O
to ADP B-O
families NOUN B-O
’ PUNCT B-O
locations NOUN B-O
may AUX B-O
improve VERB B-O
the DET B-O
early ADJ B-O
identification NOUN B-O
of ADP B-O
cases NOUN B-O
compared VERB B-O
to ADP B-O
outpatient NOUN B-O
treatment NOUN B-O
at ADP B-O
health NOUN B-LF
facilities NOUN I-LF
( PUNCT B-O
HFs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
with ADP B-O
a DET B-O
decreased VERB B-O
number NOUN B-O
complicated ADJ B-O
cases NOUN B-O
referred VERB B-O
to ADP B-O
stabilization NOUN B-O
centers NOUN B-O
, PUNCT B-O
increased VERB B-O
anthropometric ADJ B-O
measurements NOUN B-O
at ADP B-O
admission NOUN B-O
( PUNCT B-O
closer ADJ B-O
to ADP B-O
the DET B-O
admission NOUN B-O
threshold NOUN B-O
) PUNCT B-O
and CCONJ B-O
similarity NOUN B-O
in ADP B-O
clinical ADJ B-O
outcomes NOUN B-O
( PUNCT B-O
cure NOUN B-O
, PUNCT B-O
death NOUN B-O
, PUNCT B-O
and CCONJ B-O
default NOUN B-O
) PUNCT B-O
. PUNCT B-O

Patients NOUN B-O
are AUX B-O
triaged VERB B-O
to ADP B-O
three NUM B-O
sections NOUN B-O
of ADP B-O
the DET B-O
ED PROPN B-AC
( PUNCT B-O
High ADJ B-O
Acuity NOUN B-O
, PUNCT B-O
Low ADJ B-O
Acuity NOUN B-O
and CCONJ B-O
Pediatrics NOUN B-O
) PUNCT B-O
based VERB B-O
on ADP B-O
the DET B-O
Emergency PROPN B-LF
Severity PROPN I-LF
Index PROPN I-LF
( PUNCT B-O
ESI PROPN B-AC
) PUNCT B-O
and CCONJ B-O
age NOUN B-O
. PUNCT B-O

AP1 PROPN B-AC
, PUNCT B-O
activator NOUN B-LF
protein NOUN I-LF
1 NUM I-LF
; PUNCT B-O
bHLH PROPN B-O
, PUNCT B-O
basic ADJ B-O
helix NOUN B-O
- PUNCT B-O
loop NOUN B-O
- PUNCT B-O
helix NOUN B-O
; PUNCT B-O
ChIP PROPN B-AC
, PUNCT B-O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
and CCONJ I-LF
sequencing NOUN I-LF
; PUNCT B-O
-SeqdnIκBα PROPN B-AC
, PUNCT B-O
dominant ADJ B-O
negative ADJ B-O
NFKB PROPN B-O
inhibitor NOUN B-O
alpha NOUN B-O
; PUNCT B-O
FDR PROPN B-AC
, PUNCT B-O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
; PUNCT B-O
GO PROPN B-AC
, PUNCT B-O
Gene PROPN B-LF
Ontology PROPN I-LF
; PUNCT B-O
NF PROPN B-AC
, PUNCT B-O
nuclear ADJ B-LF
factor NOUN I-LF
kappa NOUN I-LF
B NOUN I-LF
; PUNCT B-O
PPARG PROPN B-O
, PUNCT B-O
peroxisome NOUN B-O
proliferator NOUN B-O
– PUNCT B-O
activated VERB B-O
receptor NOUN B-O
gamma NOUN B-O
; PUNCT B-O
-κBRNA PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT B-O
SOX8 PROPN B-O
, PUNCT B-O
SRY NOUN B-O
- PUNCT B-O
box NOUN B-O
8 NUM B-O
; PUNCT B-O
-SeqTet PROPN B-AC
, PUNCT B-O
tetracycline NOUN B-LF
. PUNCT B-O

Antibodies NOUN B-O
were AUX B-O
used VERB B-O
at ADP B-O
dilutions NOUN B-O
recommended VERB B-O
by ADP B-O
the DET B-O
manufacturers NOUN B-O
. PUNCT B-O

1 NUM B-O
- PUNCT B-O
methyl-4 NOUN B-O
- PUNCT B-O
phenylpyridinium NOUN B-O
( PUNCT B-O
MPP+ NOUN B-O
) PUNCT B-O
, PUNCT B-O
adenosine NOUN B-LF
- PUNCT I-LF
triphosphate NOUN I-LF
( PUNCT B-O
ATP PROPN B-AC
) PUNCT B-O
were AUX B-O
obtained VERB B-O
from ADP B-O
Sigma PROPN B-O
- PUNCT B-O
Aldrich PROPN B-O
. PUNCT B-O

Another DET B-O
example NOUN B-O
is AUX B-O
the DET B-O
World PROPN B-O
Bank PROPN B-O
and CCONJ B-O
UNICEF PROPN B-O
– PUNCT B-O
funded VERB B-O
Child PROPN B-LF
Survival PROPN I-LF
and CCONJ I-LF
Safe PROPN I-LF
Motherhood PROPN I-LF
( PUNCT B-O
CSSM PROPN B-AC
) PUNCT B-O
Program PROPN B-O
, PUNCT B-O
which PRON B-O
was AUX B-O
implemented VERB B-O
from ADP B-O
1992–93 NUM B-O
to ADP B-O
1997–98 NUM B-O
and CCONJ B-O
later ADV B-O
merged VERB B-O
into ADP B-O
the DET B-O
Reproductive PROPN B-LF
and CCONJ I-LF
Child PROPN I-LF
Health PROPN I-LF
( PUNCT B-O
RCH PROPN B-AC
) PUNCT B-O
program NOUN B-O
in ADP B-O
1997–98 NUM B-O
( PUNCT B-O
http://mohfw.nic.in/dofw%20website/Child%20healthrti.pdf X B-O
) PUNCT B-O
. PUNCT B-O

Following VERB B-O
24 NUM B-O
h NOUN B-O
to ADP B-O
48h NUM B-O
of ADP B-O
transfection NOUN B-O
( PUNCT B-O
Lipofectamine PROPN B-O
2000 NUM B-O
, PUNCT B-O
Invitrogen PROPN B-O
) PUNCT B-O
of ADP B-O
3μg ADP B-O
of ADP B-O
expression NOUN B-O
plasmid(s NOUN B-O
) PUNCT B-O
, PUNCT B-O
100 NUM B-O
mm NOUN B-O
diameter NOUN B-O
plates NOUN B-O
of ADP B-O
HEK293 NOUN B-O
T NOUN B-O
cells NOUN B-O
were AUX B-O
washed VERB B-O
in ADP B-O
cold ADJ B-O
PBS PROPN B-O
, PUNCT B-O
lysed VERB B-O
in ADP B-O
1ml NUM B-O
of ADP B-O
TX100 PROPN B-AC
lysis NOUN B-O
buffer NOUN B-O
containing VERB B-O
Tris PROPN B-O
50mM PROPN B-O
PH:7.5 NUM B-O
, PUNCT B-O
NaCl PROPN B-O
150 NUM B-O
mM NOUN B-O
1 NUM B-O
% NOUN B-O
of ADP B-O
Triton PROPN B-LF
X100 NUM I-LF
and CCONJ B-O
a DET B-O
complete ADJ B-O
protease NOUN B-O
inhibitor NOUN B-O
cocktail NOUN B-O
( PUNCT B-O
Roche PROPN B-O
) PUNCT B-O
. PUNCT B-O

Baseline ADJ B-O
categorical ADJ B-O
data NOUN B-O
are AUX B-O
presented VERB B-O
as ADP B-O
frequency NOUN B-O
( PUNCT B-O
percent NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
continuous ADJ B-O
data NOUN B-O
are AUX B-O
presented VERB B-O
as ADP B-O
median NOUN B-O
( PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
[ X B-O
IQR PROPN B-AC
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
the DET B-O
present ADJ B-O
study NOUN B-O
, PUNCT B-O
we PRON B-O
have AUX B-O
examined VERB B-O
the DET B-O
possibility NOUN B-O
that SCONJ B-O
the DET B-O
Fat1 PROPN B-AC
cadherin NOUN B-O
, PUNCT B-O
a DET B-O
planar NOUN B-LF
cell NOUN I-LF
polarity NOUN I-LF
( PUNCT B-O
PCP PROPN B-AC
) PUNCT B-O
molecule NOUN B-O
involved VERB B-O
in ADP B-O
tissue NOUN B-O
morphogenesis NOUN B-O
, PUNCT B-O
could AUX B-O
contribute VERB B-O
to PART B-O
coordinate NOUN B-O
muscular ADJ B-O
and CCONJ B-O
neuronal ADJ B-O
morphogenesis NOUN B-O
. PUNCT B-O

TheRe PROPN B-AC
is AUX B-O
calculated VERB B-O
by ADP B-O
: PUNCT B-O
Re PROPN B-AC
= ADP B-O
uwdbνw(18 NUM B-O
) PUNCT B-O
where SCONJ B-O
uw PROPN B-AC
( PUNCT B-O
m PROPN B-AC
/ NOUN B-O
s PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
velocity NOUN B-O
of ADP B-O
water NOUN B-O
, PUNCT B-O
db PROPN B-AC
( PUNCT B-O
m PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
diameter NOUN B-O
of ADP B-O
heat NOUN B-O
exchange NOUN B-O
borehole NOUN B-O
, PUNCT B-O
and CCONJ B-O
νw PROPN B-AC
( PUNCT B-O
m2 PROPN B-AC
/ NOUN B-O
s PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
dynamic ADJ B-LF
viscosity NOUN I-LF
of ADP I-LF
water NOUN I-LF
. PUNCT B-O

Similarly ADV B-O
, PUNCT B-O
this DET B-O
study NOUN B-O
found VERB B-O
HIV PROPN B-AC
testing NOUN B-O
as SCONJ B-O
part NOUN B-O
of ADP B-O
the DET B-O
requirements NOUN B-O
of ADP B-O
focused VERB B-O
antenatal ADJ B-LF
care NOUN I-LF
package NOUN B-O
to PART B-O
be AUX B-O
a DET B-O
barrier NOUN B-O
for SCONJ B-O
both DET B-O
men NOUN B-O
and CCONJ B-O
women NOUN B-O
to PART B-O
attend VERB B-O
at ADP B-O
ANC PROPN B-AC
. PUNCT B-O

It PRON B-O
was AUX B-O
noted VERB B-O
that SCONJ B-O
men NOUN B-O
felt VERB B-O
obligated ADJ B-O
to PART B-O
attend VERB B-O
ANC PROPN B-AC
with ADP B-O
their PRON B-O
partners NOUN B-O
on ADP B-O
the DET B-O
first ADJ B-O
ANC PROPN B-AC
visit NOUN B-O
so SCONJ B-O
that SCONJ B-O
their PRON B-O
partners NOUN B-O
may AUX B-O
not PART B-O
be AUX B-O
denied VERB B-O
services NOUN B-O
when SCONJ B-O
unaccompanied ADJ B-O
, PUNCT B-O
even ADV B-O
as SCONJ B-O
some PRON B-O
dreaded VERB B-O
HIV PROPN B-AC
testing NOUN B-O
. PUNCT B-O

As SCONJ B-O
the DET B-O
Thai ADJ B-O
Ministry PROPN B-LF
of ADP I-LF
Public PROPN I-LF
Health PROPN I-LF
( PUNCT B-O
MoPH PROPN B-AC
) NOUN B-O
policy NOUN B-O
requires VERB B-O
insecticide NOUN B-O
spraying NOUN B-O
both CCONJ B-O
upon SCONJ B-O
identification NOUN B-O
of ADP B-O
a DET B-O
dengue NOUN B-O
case NOUN B-O
and CCONJ B-O
7 NUM B-O
d NOUN B-O
later ADV B-O
, NOUN B-O
the DET B-O
study NOUN B-O
team NOUN B-O
provided VERB B-O
the DET B-O
initial ADJ B-O
spraying NOUN B-O
and CCONJ B-O
the DET B-O
Thai ADJ B-O
MoPH PROPN B-AC
provided VERB B-O
the DET B-O
day NOUN B-O
7 NUM B-O
spraying NOUN B-O
( PUNCT B-O
deltamethrin NOUN B-O
or CCONJ B-O
permethrin NOUN B-O
10 NUM B-O
% NOUN B-O
) NOUN B-O
, NOUN B-O
regardless ADV B-O
of ADP B-O
the DET B-O
dengue NOUN B-O
PCR PROPN B-AC
status NOUN B-O
of ADP B-O
the DET B-O
index NOUN B-O
case NOUN B-O
for ADP B-O
that DET B-O
cluster NOUN B-O
. PUNCT B-O

EM PROPN B-O
, PUNCT B-O
electron NOUN B-O
microscopy NOUN B-O
; PUNCT B-O
Fab PROPN B-AC
, PUNCT B-O
fragment NOUN B-LF
antigen NOUN I-LF
binding VERB I-LF
; PUNCT B-O
HA PROPN B-AC
, PUNCT B-O
hemagglutinin NOUN B-LF
; PUNCT B-O
nsEM PROPN B-AC
, PUNCT B-O
negative ADJ B-O
- PUNCT B-O
stain NOUN B-O
EM PROPN B-O
; PUNCT B-O
PDB PROPN B-AC
, PUNCT B-O
Protein PROPN B-LF
Data PROPN I-LF
Bank PROPN I-LF
. PUNCT B-O

FI PROPN B-AC
, PUNCT B-O
RpfF NOUN B-LF
interaction NOUN I-LF
RpfF PROPN B-AC
; PUNCT B-O
PAS PROPN B-AC
, PUNCT B-O
Per PROPN B-LF
- PUNCT I-LF
Arnt PROPN I-LF
- PUNCT I-LF
Sim PROPN I-LF
; PUNCT B-O
RpfF PROPN B-AC
, PUNCT B-O
regulation NOUN B-LF
of ADP I-LF
pathogenicity NOUN I-LF
factor NOUN I-LF
F PROPN I-LF
; PUNCT B-O
RpfR PROPN B-AC
, PUNCT B-O
regulation NOUN B-LF
of ADP I-LF
pathogenicity NOUN I-LF
factor NOUN I-LF
R NOUN I-LF
; PUNCT B-O
SUMO PROPN B-AC
, PUNCT B-O
small ADJ B-LF
ubiquitin NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
modifier NOUN I-LF
. PUNCT B-O

Effect NOUN B-O
of ADP B-O
non ADJ B-O
- ADJ B-O
Darcy ADJ B-O
flow NOUN B-O
can AUX B-O
be PROPN B-AC
considered VERB B-O
by ADP B-O
adjusting VERB B-O
the DET B-O
slip NOUN B-LF
coefficient NOUN I-LF
which PRON B-O
appereas VERB B-O
in ADP B-O
Eq NOUN B-O
( PUNCT B-O
30 NUM B-O
) PUNCT B-O
. PUNCT B-O

To PART B-O
observe VERB B-O
the DET B-O
location NOUN B-O
of ADP B-O
P. PROPN B-O
berghei PROPN B-O
proteins NOUN B-O
, PUNCT B-O
the DET B-O
C NOUN B-O
- PUNCT B-O
terminus NOUN B-O
of ADP B-O
the DET B-O
gene NOUN B-O
was AUX B-O
tagged VERB B-O
with ADP B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
GFP PROPN B-AC
) PUNCT B-O
sequence NOUN B-O
by ADP B-O
single ADJ B-O
crossover NOUN B-O
homologous ADJ B-O
recombination NOUN B-O
. PUNCT B-O

Gestational ADJ B-LF
diabetes NOUN I-LF
mellitus NOUN I-LF
( PUNCT B-O
GDM PROPN B-AC
) PUNCT B-O
is AUX B-O
defined VERB B-O
as ADP B-O
any DET B-O
degree NOUN B-O
of ADP B-O
glucose NOUN B-O
intolerance NOUN B-O
with ADP B-O
onset NOUN B-O
or CCONJ B-O
first ADJ B-O
recognition NOUN B-O
during ADP B-O
pregnancy NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Furthermore ADV B-O
induction NOUN B-O
of ADP B-O
diabetes NOUN B-O
type NOUN B-O
1 NUM B-O
induced VERB B-O
a DET B-O
decrease NOUN B-O
in ADP B-O
major ADJ B-O
angiogenic ADJ B-O
growth NOUN B-O
factor NOUN B-O
in ADP B-O
the DET B-O
skeletal ADJ B-O
muscle NOUN B-O
capillary ADJ B-O
bed NOUN B-O
of ADP B-O
mice.[6 NOUN B-O
] PUNCT B-O
In ADP B-O
a DET B-O
chicken NOUN B-O
model NOUN B-O
of ADP B-O
neoangiogenesis NOUN B-O
, PUNCT B-O
hyperglycemia NOUN B-O
was AUX B-O
shown VERB B-O
to ADP B-O
impair VERB B-O
angiogenesis NOUN B-O
through ADP B-O
induction NOUN B-O
of ADP B-O
apoptosis NOUN B-O
and CCONJ B-O
decreases VERB B-O
proliferation NOUN B-O
of ADP B-O
endothelial ADJ B-O
cells.[7 NOUN B-O
] PUNCT B-O
In ADP B-O
a DET B-O
diabetic ADJ B-O
mouse NOUN B-O
model NOUN B-O
with ADP B-O
hindlimb NOUN B-O
- ADJ B-O
induced VERB B-O
ischemia NOUN B-O
, PUNCT B-O
restoration NOUN B-O
of ADP B-O
perfusion NOUN B-O
in ADP B-O
the DET B-O
ischemic ADJ B-O
limb NOUN B-O
was AUX B-O
impaired VERB B-O
and CCONJ B-O
capillary ADJ B-O
density NOUN B-O
reduced.[8 VERB B-O
] PUNCT B-O
Goligorsky PROPN B-O
and CCONJ B-O
colleagues NOUN B-O
demonstrated VERB B-O
an DET B-O
angiogenic ADJ B-O
switch NOUN B-O
during ADP B-O
natural ADJ B-O
history NOUN B-O
of ADP B-O
type NOUN B-LF
2 NUM I-LF
diabetes NOUN I-LF
mellitus NOUN I-LF
( PUNCT B-O
T2DM PROPN B-AC
) PUNCT B-O
from ADP B-O
pro ADJ B-O
- ADJ B-O
angiogenic ADJ B-O
phenotype NOUN B-O
at ADP B-O
the DET B-O
early ADJ B-O
pre ADJ B-O
- ADJ B-O
diabetic ADJ B-O
stages NOUN B-O
to ADP B-O
the DET B-O
profound ADJ B-O
inhibition NOUN B-O
of ADP B-O
ex ADJ B-O
- ADJ B-O
vivo ADJ B-O
angiogenesis NOUN B-O
and CCONJ B-O
microvascular ADJ B-O
rarefaction NOUN B-O
in ADP B-O
the DET B-O
kidneys NOUN B-O
of ADP B-O
obese ADJ B-O
zucker PROPN B-O
diabetic ADJ B-O
fat ADJ B-O
rats.[5 NOUN B-O
] PUNCT B-O
Peritubular ADJ B-O
capillary ADJ B-O
rarefaction NOUN B-O
is VERB B-O
a DET B-O
major ADJ B-O
hallmark NOUN B-O
of ADP B-O
chronic ADJ B-O
kidney NOUN B-O
disease NOUN B-O
and CCONJ B-O
predicts VERB B-O
renal ADJ B-O
outcome NOUN B-O
in ADP B-O
diabetic ADJ B-O
nephropathy.[9 NOUN B-O
] PUNCT B-O
There PRON B-O
is VERB B-O
evidence NOUN B-O
from ADP B-O
animal NOUN B-O
models NOUN B-O
that SCONJ B-O
endothelial ADJ B-O
dysfunction NOUN B-O
, PUNCT B-O
oxidative ADJ B-O
stress NOUN B-O
, PUNCT B-O
interstitial ADJ B-O
hypoxia NOUN B-O
due ADP B-O
to ADP B-O
arteriolar ADJ B-O
vasoconstriction NOUN B-O
and CCONJ B-O
pericyte NOUN B-O
detachment NOUN B-O
from ADP B-O
the DET B-O
vasculature NOUN B-O
are AUX B-O
involved VERB B-O
in ADP B-O
this DET B-O
pathophysiological ADJ B-O
process.[9 NOUN B-O
] PUNCT B-O
Initially ADV B-O
thought VERB B-O
to PART B-O
be AUX B-O
absent ADJ B-O
in ADP B-O
mammals NOUN B-O
, PUNCT B-O
small ADJ B-O
quantities NOUN B-O
of ADP B-O
α PUNCT B-O
- PUNCT B-O
linked VERB B-O
monoglycosylceramides NOUN B-O
( PUNCT B-O
e.g. X B-O
, PUNCT B-O
α PUNCT B-LF
- PUNCT I-LF
galactosylceramide NOUN I-LF
[ PUNCT B-O
α-GalCer PROPN B-AC
] PUNCT B-O
) PUNCT B-O
that PRON B-O
may AUX B-O
act VERB B-O
as ADP B-O
iNKT PROPN B-AC
cell NOUN B-O
self NOUN B-O
- PUNCT B-O
Ags PROPN B-AC
have AUX B-O
been AUX B-O
identified VERB B-O
[ PUNCT B-O
14 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
effect NOUN B-O
size NOUN B-O
for ADP B-O
the DET B-O
primary ADJ B-O
and CCONJ B-O
secondary ADJ B-O
outcomes NOUN B-O
was AUX B-O
evaluated VERB B-O
as ADP B-O
the DET B-O
standardized ADJ B-LF
mean NOUN I-LF
difference NOUN I-LF
( PUNCT B-O
SMD PROPN B-AC
) PUNCT B-O
in ADP B-O
testing VERB B-O
frequency NOUN B-O
between ADP B-O
intervention NOUN B-O
and CCONJ B-O
control NOUN B-O
arms NOUN B-O
. PUNCT B-O

Activation NOUN B-O
of ADP B-O
MET PROPN B-AC
signaling NOUN B-O
cascade NOUN B-O
by ADP B-O
its PRON B-O
ligand NOUN B-O
HGF PROPN B-O
results VERB B-O
in ADP B-O
colony NOUN B-O
dispersal NOUN B-O
, PUNCT B-O
epithelial ADJ B-LF
- PUNCT I-LF
mesenchymal NOUN I-LF
transition NOUN I-LF
( PUNCT B-O
EMT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
increased VERB B-O
motility NOUN B-O
[ PUNCT B-O
40 NUM B-O
] PUNCT B-O
. PUNCT B-O

When SCONJ B-O
DCs PROPN B-AC
mature VERB B-O
, PUNCT B-O
they PRON B-O
synthesize VERB B-O
high ADJ B-O
levels NOUN B-O
of ADP B-O
NO PROPN B-AC
, PUNCT B-O
interleukin NOUN B-LF
( PUNCT B-O
IL PROPN B-AC
) PUNCT B-O
12 NUM B-O
, PUNCT B-O
and CCONJ B-O
RANTES PROPN B-AC
, PUNCT B-O
and CCONJ B-O
express VERB B-O
more ADV B-O
costimulatory ADJ B-O
molecules NOUN B-O
such ADJ B-O
as ADP B-O
CD86 PROPN B-O
and CCONJ B-O
major ADJ B-LF
histocompatibility NOUN I-LF
complex NOUN I-LF
( PUNCT B-O
MHC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
all PRON B-O
of ADP B-O
which PRON B-O
can AUX B-O
induce VERB B-O
T NOUN B-O
cells NOUN B-O
to ADP B-O
become VERB B-O
fully ADV B-O
activated ADJ B-O
to ADP B-O
initial ADJ B-O
immune ADJ B-O
response NOUN B-O
[ PUNCT B-O
19 NUM B-O
] PUNCT B-O
. PUNCT B-O

Clot NOUN B-O
formation NOUN B-O
inside ADP B-O
one NUM B-O
of ADP B-O
the DET B-O
veins NOUN B-O
deep ADJ B-O
in ADP B-O
the DET B-O
body NOUN B-O
( PUNCT B-O
usually ADV B-O
in ADP B-O
a DET B-O
leg NOUN B-O
) PUNCT B-O
is AUX B-O
called VERB B-O
deep ADJ B-LF
vein NOUN I-LF
thrombosis NOUN I-LF
( PUNCT B-O
DVT PROPN B-AC
) PUNCT B-O
. PUNCT B-O

DVT PROPN B-AC
, PUNCT B-O
which PRON B-O
can AUX B-O
cause VERB B-O
pain NOUN B-O
, PUNCT B-O
swelling NOUN B-O
, PUNCT B-O
and CCONJ B-O
redness NOUN B-O
in ADP B-O
the DET B-O
affected VERB B-O
limb NOUN B-O
, PUNCT B-O
is AUX B-O
treated VERB B-O
with ADP B-O
anticoagulants NOUN B-O
, PUNCT B-O
drugs NOUN B-O
that PRON B-O
stop VERB B-O
the DET B-O
clot NOUN B-O
growing VERB B-O
. PUNCT B-O

This DET B-O
complex NOUN B-O
is AUX B-O
mainly ADV B-O
composed VERB B-O
of ADP B-O
four NUM B-O
subunits NOUN B-O
: PUNCT B-O
a DET B-O
heterodimer NOUN B-O
of ADP B-O
two NUM B-O
structural ADJ B-LF
maintenance NOUN I-LF
of ADP I-LF
chromosome NOUN I-LF
proteins NOUN I-LF
( PUNCT B-O
SMC1 PROPN B-O
and CCONJ B-O
SMC3 PROPN B-O
) PUNCT B-O
, PUNCT B-O
associated VERB B-O
with ADP B-O
two NUM B-O
non ADJ B-O
- ADJ B-O
SMC PROPN B-AC
components NOUN B-O
corresponding VERB B-O
to ADP B-O
sister NOUN B-O
chromatid NOUN B-O
cohesion NOUN B-O
proteins NOUN B-O
( PUNCT B-O
SCC1 PROPN B-O
and CCONJ B-O
SCC3 PROPN B-O
) PUNCT B-O
[ X B-O
3–6 NUM B-O
] PUNCT B-O
; PUNCT B-O
and CCONJ B-O
for ADP B-O
review NOUN B-O
see VERB B-O
[ X B-O
7,8 NUM B-O
] PUNCT B-O
. PUNCT B-O

Using VERB B-O
liquid NOUN B-LF
chromatography NOUN I-LF
high ADJ I-LF
- PUNCT I-LF
resolution NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT B-O
LC-HR-MS/MS PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
, PUNCT B-O
we PRON B-O
discovered VERB B-O
1,360 NUM B-O
differentially ADV B-O
expressed VERB B-O
proteins NOUN B-O
in ADP B-O
CLL PROPN B-AC
patients NOUN B-O
compared VERB B-O
to PART B-O
healthy ADJ B-O
donors NOUN B-O
, PUNCT B-O
several ADJ B-O
of ADP B-O
which PRON B-O
had AUX B-O
been AUX B-O
previously ADV B-O
reported VERB B-O
to PART B-O
be AUX B-O
associated VERB B-O
with ADP B-O
cancer NOUN B-O
, PUNCT B-O
yet CCONJ B-O
four NUM B-O
of ADP B-O
which PRON B-O
were AUX B-O
identified VERB B-O
as ADP B-O
being AUX B-O
associated VERB B-O
with ADP B-O
any DET B-O
cancer NOUN B-O
, PUNCT B-O
including VERB B-O
CLL PROPN B-AC
, PUNCT B-O
for ADP B-O
the DET B-O
first ADJ B-O
time NOUN B-O
. PUNCT B-O

Similar ADJ B-O
improvements NOUN B-O
in ADP B-O
systolic ADJ B-O
and CCONJ B-O
diastolic ADJ B-O
BP PROPN B-AC
to ADP B-O
those PRON B-O
observed VERB B-O
in ADP B-O
this DET B-O
trial NOUN B-O
of ADP B-O
3.3 NUM B-O
and CCONJ B-O
1.4 NUM B-O
mmHg NOUN B-O
were AUX B-O
reported VERB B-O
in ADP B-O
the DET B-O
Heart PROPN B-LF
Outcome PROPN I-LF
Prevention PROPN I-LF
Evaluation PROPN I-LF
( PUNCT B-O
HOPE PROPN B-AC
) PUNCT B-O
study NOUN B-O
and CCONJ B-O
were AUX B-O
associated VERB B-O
with ADP B-O
a DET B-O
22 NUM B-O
% NOUN B-O
reduction NOUN B-O
in ADP B-O
relative ADJ B-O
risk NOUN B-O
of ADP B-O
cardiovascular ADJ B-O
mortality NOUN B-O
, PUNCT B-O
myocardial ADJ B-O
infarction NOUN B-O
, PUNCT B-O
or CCONJ B-O
stroke NOUN B-O
[ PUNCT B-O
23 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
expression NOUN B-O
of ADP B-O
the DET B-O
major ADJ B-O
inflammatory ADJ B-O
cytokines NOUN B-O
, PUNCT B-O
IL-6 PROPN B-AC
, PUNCT B-O
IL-1β NOUN B-O
and CCONJ B-O
TNF PROPN B-AC
, PUNCT B-O
in ADP B-O
spinal ADJ B-O
cords NOUN B-O
of ADP B-O
these DET B-O
SOD1 NOUN B-O
transgenic ADJ B-LF
( PUNCT B-O
-αTG PROPN B-AC
) PUNCT B-O
mice NOUN B-O
were AUX B-O
assessed VERB B-O
by ADP B-O
real ADJ B-O
time NOUN B-O
PCR NOUN B-O
. PUNCT B-O

Mice NOUN B-O
were AUX B-O
then ADV B-O
crossed VERB B-O
with ADP B-O
IL-6(-/- PROPN B-AC
) PUNCT B-O
mice NOUN B-O
to PART B-O
generate VERB B-O
SOD1TG NOUN B-O
/ SYM B-O
IL-6(-/- PROPN B-AC
) PUNCT B-O
mice NOUN B-O
. PUNCT B-O

In ADP B-O
female ADJ B-O
mouse NOUN B-LF
embryo NOUN I-LF
fibroblasts NOUN I-LF
( PUNCT B-O
MEFs PROPN B-AC
) PUNCT B-O
exhibiting VERB B-O
DD NOUN B-O
signals NOUN B-O
for ADP B-O
Pgk1 NOUN B-O
, PUNCT B-O
the DET B-O
distribution NOUN B-O
of ADP B-O
D PROPN B-AC
/ SYM B-O
D PROPN B-AC
intensity NOUN B-O
ratios NOUN B-O
centered VERB B-O
around ADP B-O
1 NUM B-O
( PUNCT B-O
Figure PROPN B-O
1E NUM B-O
) PUNCT B-O
, PUNCT B-O
demonstrating VERB B-O
that SCONJ B-O
two NUM B-O
replicated VERB B-O
alleles NOUN B-O
display VERB B-O
equal ADJ B-O
signal NOUN B-O
intensities NOUN B-O
. PUNCT B-O

There PRON B-O
is VERB B-O
no DET B-O
dignity NOUN B-O
… PUNCT B-O
. PUNCT B-O

” PUNCT B-O
Account NOUN B-O
told VERB B-O
by ADP B-O
a DET B-O
16 NUM B-O
- PUNCT B-O
year NOUN B-O
- PUNCT B-O
old ADJ B-O
Sudanese ADJ B-O
boy NOUN B-O
to ADP B-O
Médecins PROPN B-LF
Sans PROPN I-LF
Frontières PROPN I-LF
( PUNCT B-O
MSF PROPN B-AC
) PUNCT B-O
staff NOUN B-O
, PUNCT B-O
after ADP B-O
being AUX B-O
rescued VERB B-O
on ADP B-O
the DET B-O
Mediterranean PROPN B-O
Sea PROPN B-O
in ADP B-O
August PROPN B-O
2019 NUM B-O
. PUNCT B-O

To PART B-O
examine VERB B-O
and CCONJ B-O
compare VERB B-O
changes NOUN B-O
in ADP B-O
strength NOUN B-O
and CCONJ B-O
physical ADJ B-O
function NOUN B-O
from ADP B-O
pre- ADJ B-O
to ADP B-O
post ADJ B-O
- ADJ B-O
diagnosis NOUN B-O
among ADP B-O
men NOUN B-O
with ADP B-O
prostate NOUN B-LF
cancer ADJ I-LF
( PUNCT B-O
PC PROPN B-AC
, PUNCT B-O
[ X B-O
cases NOUN B-O
] PUNCT B-O
) PUNCT B-O
and CCONJ B-O
matched VERB B-O
non ADJ B-O
- ADJ B-O
cancer ADJ B-O
controls NOUN B-O
identified VERB B-O
from ADP B-O
the DET B-O
Health PROPN B-O
, PUNCT B-O
Aging PROPN B-O
and CCONJ B-O
Body PROPN B-O
Composition PROPN B-O
( PUNCT B-O
HealthABC PROPN B-AC
) PUNCT B-O
study NOUN B-O
. PUNCT B-O

The DET B-O
specific ADJ B-O
expression NOUN B-O
of ADP B-O
desatF NOUN B-O
in ADP B-O
D. PROPN B-O
melanogaster NOUN B-O
females NOUN B-O
was AUX B-O
due ADJ B-O
to ADP B-O
a DET B-O
special ADJ B-O
cis ADJ B-LF
- PUNCT I-LF
regulatory ADJ I-LF
element NOUN I-LF
( PUNCT B-O
CRE PROPN B-AC
) PUNCT B-O
located VERB B-O
upstream ADV B-O
of ADP B-O
desatF NOUN B-O
in ADP B-O
D. PROPN B-O
melanogaster NOUN B-O
; PUNCT B-O
the DET B-O
CRE PROPN B-AC
presented VERB B-O
a DET B-O
doublesex PROPN B-O
protein NOUN B-O
( PUNCT B-O
Doublesx PROPN B-LF
, PUNCT B-O
Dsx PROPN B-AC
) PUNCT B-O
binding NOUN B-O
site NOUN B-O
that PRON B-O
could AUX B-O
be AUX B-O
recognized VERB B-O
by ADP B-O
the DET B-O
female NOUN B-O
- PUNCT B-O
specific ADJ B-O
isoform NOUN B-O
of ADP B-O
Dsx PROPN B-AC
( PUNCT B-O
Dsx PROPN B-AC
- PUNCT B-O
F PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
binding NOUN B-O
of ADP B-O
Dsx PROPN B-AC
- PUNCT B-O
F PROPN B-O
activated VERB B-O
the DET B-O
transcription NOUN B-O
of ADP B-O
desatF NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
male NOUN B-O
- PUNCT B-O
specific ADJ B-O
Dsx PROPN B-AC
showed VERB B-O
no DET B-O
regulatory ADJ B-O
activity NOUN B-O
, PUNCT B-O
resulting VERB B-O
in ADP B-O
sexual ADJ B-O
dimorphism NOUN B-O
of ADP B-O
desatF NOUN B-O
expression NOUN B-O
[ PUNCT B-O
42 NUM B-O
] PUNCT B-O
. PUNCT B-O

DEG PROPN B-AC
, PUNCT B-O
differentially ADV B-LF
expressed VERB I-LF
gene NOUN I-LF
; PUNCT B-O
IL-4 PROPN B-AC
, PUNCT B-O
interleukin-4 NOUN B-LF
. PUNCT B-O

This PRON B-O
included VERB B-O
the DET B-O
integration NOUN B-O
of ADP B-O
principles NOUN B-O
from ADP B-O
Self PROPN B-LF
- PUNCT I-LF
Determination PROPN I-LF
Theory PROPN I-LF
( PUNCT B-O
SDT PROPN B-AC
) PUNCT B-O
as ADP B-O
a DET B-O
means NOUN B-O
to PART B-O
strengthen VERB B-O
the DET B-O
quality NOUN B-O
, PUNCT B-O
quantity NOUN B-O
, PUNCT B-O
and CCONJ B-O
longevity NOUN B-O
of ADP B-O
motivation NOUN B-O
to PART B-O
change VERB B-O
health NOUN B-O
behaviours NOUN B-O
[ PUNCT B-O
25 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
PAM2 PROPN B-O
Off PROPN B-O
- PUNCT B-O
Target NOUN B-O
# NOUN B-O
2 NUM B-O
template NOUN B-O
( PUNCT B-O
accession NOUN B-O
XM_021073251.1 NOUN B-O
) PUNCT B-O
is AUX B-O
predicted VERB B-O
to ADP B-O
encode VERB B-O
for ADP B-O
an DET B-O
mRNA NOUN B-O
transcript NOUN B-O
for ADP B-O
aminoadipate NOUN B-LF
aminotransferase NOUN I-LF
( PUNCT B-O
AADAT PROPN B-AC
) PUNCT B-O
. PUNCT B-O

AADAT PROPN B-AC
is AUX B-O
an DET B-O
enzyme NOUN B-O
found VERB B-O
primarily ADV B-O
in ADP B-O
the DET B-O
brain NOUN B-O
and CCONJ B-O
known VERB B-O
to ADP B-O
catalyze VERB B-O
the DET B-O
transamination NOUN B-O
of ADP B-O
kynurenine NOUN B-O
to ADP B-O
kynurenic NOUN B-O
acid NOUN B-O
; PUNCT B-O
AADAT PROPN B-AC
is AUX B-O
also ADV B-O
responsible ADJ B-O
for ADP B-O
the DET B-O
transamination NOUN B-O
of ADP B-O
aminoapidate NOUN B-O
to ADP B-O
alpha NOUN B-O
- PUNCT B-O
oxoadipate[17 NOUN B-O
] PUNCT B-O
. PUNCT B-O

DIC PROPN B-AC
, PUNCT B-O
differential ADJ B-LF
interference NOUN I-LF
contrast NOUN I-LF
; PUNCT B-O
EXP1 PROPN B-AC
, PUNCT B-O
exported VERB B-LF
protein NOUN I-LF
1 NUM I-LF
; PUNCT B-O
HA PROPN B-O
, PUNCT B-O
triple ADJ B-O
hemagglutinin NOUN B-O
tag NOUN B-O
; PUNCT B-O
KAHRP PROPN B-AC
, PUNCT B-O
knob NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
histidine NOUN I-LF
- PUNCT I-LF
rich ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
pA NOUN B-O
, PUNCT B-O
Picoampere NOUN B-O
; PUNCT B-O
PSAC PROPN B-AC
, PUNCT B-O
parasite NOUN B-LF
surface NOUN I-LF
anion NOUN I-LF
channel NOUN I-LF
; PUNCT B-O
PVM PROPN B-AC
, PUNCT B-O
parasitophorous ADJ B-LF
vacuolar ADJ I-LF
membrane NOUN I-LF
; PUNCT B-O
RBC PROPN B-AC
, PUNCT B-O
red ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
; PUNCT B-O
SBP1 PROPN B-AC
, PUNCT B-O
skeleton NOUN B-LF
binding VERB I-LF
protein NOUN I-LF
1 NUM I-LF
. PUNCT B-O

However ADV B-O
, PUNCT B-O
insufficient ADJ B-O
information NOUN B-O
is AUX B-O
available ADJ B-O
on ADP B-O
the DET B-O
effects NOUN B-O
of ADP B-O
fluoride NOUN B-O
on ADP B-O
human ADJ B-LF
embryonic ADJ I-LF
stem NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
hESCs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
a DET B-O
novel ADJ B-O
in ADP B-O
vitro X B-O
humanized VERB B-O
model NOUN B-O
for ADP B-O
analyzing VERB B-O
the DET B-O
embryotoxicities NOUN B-O
of ADP B-O
chemical ADJ B-O
compounds NOUN B-O
. PUNCT B-O

The DET B-O
first ADJ B-O
source NOUN B-O
is AUX B-O
the DET B-O
Human PROPN B-LF
Mortality PROPN I-LF
Database PROPN I-LF
( PUNCT B-O
HMD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
consists VERB B-O
of ADP B-O
high ADJ B-O
- PUNCT B-O
quality NOUN B-O
life NOUN B-O
tables NOUN B-O
mostly ADV B-O
from ADP B-O
Western ADJ B-O
countries NOUN B-O
. PUNCT B-O

CsINV5 PROPN B-AC
expression NOUN B-O
in ADP B-O
cultivar NOUN B-O
SCZ PROPN B-AC
increased VERB B-O
by ADP B-O
three NUM B-O
folds NOUN B-O
at ADP B-O
CA2 NOUN B-O
compared VERB B-O
with ADP B-O
less ADJ B-O
than ADP B-O
one NUM B-O
fold NOUN B-O
in ADP B-O
YH9 PROPN B-AC
( PUNCT B-O
Fig NOUN B-O
6B NUM B-O
) PUNCT B-O
. PUNCT B-O

Raffinose NOUN B-LF
synthase NOUN I-LF
gene NOUN I-LF
CsRS2 PROPN B-AC
, PUNCT B-O
responsible ADJ B-O
for ADP B-O
synthesizing NOUN B-O
of ADP B-O
raffinose NOUN B-O
, PUNCT B-O
expression NOUN B-O
was AUX B-O
also ADV B-O
increased VERB B-O
during ADP B-O
CA PROPN B-AC
in ADP B-O
variety NOUN B-O
SCZ PROPN B-AC
and CCONJ B-O
then ADV B-O
decreased VERB B-O
following VERB B-O
DA PROPN B-AC
, PUNCT B-O
while SCONJ B-O
it PRON B-O
had VERB B-O
no DET B-O
distinct ADJ B-O
changes NOUN B-O
during ADP B-O
CA PROPN B-AC
in ADP B-O
YH9 PROPN B-AC
( PUNCT B-O
Fig NOUN B-O
6B NUM B-O
) PUNCT B-O
. PUNCT B-O

This PRON B-O
suggested VERB B-O
that SCONJ B-O
the DET B-O
genes NOUN B-O
responsible ADJ B-O
for ADP B-O
sucrose NOUN B-O
and CCONJ B-O
raffinose NOUN B-O
accumulation NOUN B-O
acted VERB B-O
positively ADV B-O
to PART B-O
regulate VERB B-O
the DET B-O
corresponding VERB B-O
sugar NOUN B-O
accumulation NOUN B-O
in ADP B-O
cold ADJ B-O
treatment NOUN B-O
. PUNCT B-O

We PRON B-O
did AUX B-O
not PART B-O
observe VERB B-O
any DET B-O
association NOUN B-O
between ADP B-O
the DET B-O
grandmother NOUN B-O
’s PART B-O
smoking NOUN B-O
during ADP B-O
her PRON B-O
pregnancy NOUN B-O
and CCONJ B-O
unilateral ADJ B-O
retinoblastoma NOUN B-O
risk NOUN B-O
in ADP B-O
the DET B-O
grandchild NOUN B-O
( PUNCT B-O
OR PROPN B-AC
, PUNCT B-O
1.1 NUM B-O
; PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
, PUNCT B-O
0.5–2.1 NUM B-O
) PUNCT B-O
with ADP B-O
a DET B-O
slightly ADV B-O
increased VERB B-O
risk NOUN B-O
estimate NOUN B-O
for ADP B-O
bilateral ADJ B-O
retinoblastoma NOUN B-O
development NOUN B-O
, PUNCT B-O
but CCONJ B-O
confidence NOUN B-LF
intervals NOUN I-LF
crossed VERB B-O
the DET B-O
null ADJ B-O
( PUNCT B-O
OR PROPN B-AC
, PUNCT B-O
1.3 NUM B-O
; PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
, PUNCT B-O
0.5–3.1 NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
Poisson PROPN B-LF
generalized ADJ I-LF
likelihood NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
GLR PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
for ADP B-O
each DET B-O
window NOUN B-O
of ADP B-O
observed VERB B-O
and CCONJ B-O
expected VERB B-O
number NOUN B-O
of ADP B-O
cases NOUN B-O
in SCONJ B-O
order NOUN B-O
to PART B-O
identify VERB B-O
statistically ADV B-O
significant ADJ B-O
high ADJ B-O
risk NOUN B-O
periods NOUN B-O
. PUNCT B-O

We PRON B-O
experimentally ADV B-O
addressed VERB B-O
this DET B-O
issue NOUN B-O
by ADP B-O
studying VERB B-O
the DET B-O
maternal ADJ B-O
transmission NOUN B-O
of ADP B-O
random ADJ B-O
mtDNA PROPN B-AC
mutations NOUN B-O
in ADP B-O
mtDNA PROPN B-AC
mutator NOUN B-O
mice NOUN B-O
expressing VERB B-O
a DET B-O
proofreading NOUN B-O
- PUNCT B-O
deficient VERB B-O
mitochondrial ADJ B-LF
DNA NOUN I-LF
polymerase NOUN B-O
. PUNCT B-O

SE PROPN B-O
: PUNCT B-O
standard ADJ B-O
error NOUN B-O
, PUNCT B-O
CI PROPN B-O
: PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
, PUNCT B-O
ANC PROPN B-AC
: PUNCT B-O
antenatal ADJ B-LF
care NOUN I-LF
, PUNCT B-O
SHP PROPN B-O
: PUNCT B-O
skilled ADJ B-O
health NOUN B-O
professionals NOUN B-O
Dichotomous ADJ B-O
events NOUN B-O
or CCONJ B-O
odds NOUN B-LF
ratios NOUN I-LF
( PUNCT B-O
ORs PROPN B-AC
) PUNCT B-O
of ADP B-O
suicide NOUN B-O
, PUNCT B-O
suicide NOUN B-O
attempt NOUN B-O
, PUNCT B-O
and CCONJ B-O
suicidal ADJ B-O
ideation NOUN B-O
were AUX B-O
analyzed VERB B-O
using VERB B-O
multilevel ADJ B-O
meta NOUN B-O
- NOUN B-O
analyses NOUN B-O
to PART B-O
accommodate VERB B-O
the DET B-O
non NOUN B-O
- NOUN B-O
independence NOUN B-O
of ADP B-O
effect NOUN B-O
sizes NOUN B-O
. PUNCT B-O

DON PROPN B-AC
, PUNCT B-O
6 NUM B-LF
- PUNCT I-LF
Diazo-5 NOUN I-LF
- PUNCT I-LF
oxo NOUN I-LF
- PUNCT I-LF
L NOUN I-LF
- PUNCT I-LF
norleucine NOUN I-LF
; PUNCT B-O
IHC PROPN B-AC
, PUNCT B-O
immunohistochemistry NOUN B-LF
; PUNCT B-O
MEF PROPN B-AC
, PUNCT B-O
mouse NOUN B-LF
embryonic ADJ I-LF
fibroblast NOUN I-LF
. PUNCT B-O

We PRON B-O
observed VERB B-O
a DET B-O
significant ADJ B-O
drop NOUN B-O
in ADP B-O
the DET B-O
level NOUN B-O
of ADP B-O
postoperative ADJ B-LF
sVEGFR1 PROPN B-O
than ADP B-O
that PRON B-O
of ADP B-O
the DET B-O
preoperative ADJ B-LF
( PUNCT B-O
median ADJ B-O
sVEGFR1 PROPN B-O
: PUNCT B-O
PREOP PROPN B-AC
, PUNCT B-O
189.6 NUM B-O
pg NOUN B-O
/ SYM B-O
ml NOUN B-O
; PUNCT B-O
POST PROPN B-AC
, PUNCT B-O
124.3 NUM B-O
pg NOUN B-O
/ SYM B-O
ml NOUN B-O
; PUNCT B-O
P NOUN B-O
< SYM B-O
0.0001 NUM B-O
; PUNCT B-O
Fig NUM B-O
5A NUM B-O
) PUNCT B-O
. PUNCT B-O

Unlike ADP B-O
sVEGFR1 PROPN B-O
, PUNCT B-O
we PRON B-O
did AUX B-O
not PART B-O
observe VERB B-O
significant ADJ B-O
difference NOUN B-O
in ADP B-O
the DET B-O
level NOUN B-O
of ADP B-O
serum NOUN B-O
sVEGFR2 NOUN B-O
between ADP B-O
the DET B-O
two NUM B-O
events NOUN B-O
( PUNCT B-O
median ADJ B-O
sVEGFR2 NOUN B-O
: PUNCT B-O
OPPRE PROPN B-AC
, PUNCT B-O
7773 NUM B-O
pg NOUN B-O
/ SYM B-O
ml NOUN B-O
; PUNCT B-O
OPPOST PROPN B-AC
, PUNCT B-O
8306 NUM B-O
pg NOUN B-O
/ SYM B-O
ml NOUN B-O
; PUNCT B-O
P NOUN B-O
= SYM B-O
0.976 NUM B-O
; PUNCT B-O
Fig NUM B-O
5B NUM B-O
) PUNCT B-O
. PUNCT B-O

No DET B-O
direct ADJ B-O
association NOUN B-O
between ADP B-O
soluble ADJ B-O
VEGF PROPN B-O
receptors NOUN B-O
and CCONJ B-O
OPIPVEGF-A PROPN B-AC
was AUX B-O
noted VERB B-O
. PUNCT B-O

For ADP B-O
mortality NOUN B-O
, PUNCT B-O
we PRON B-O
examined VERB B-O
deaths NOUN B-O
from ADP B-O
respiratory ADJ B-LF
and CCONJ I-LF
circulatory ADJ I-LF
( PUNCT B-O
R&C PROPN B-AC
) PUNCT B-O
conditions NOUN B-O
as ADP B-O
a DET B-O
more ADV B-O
specific ADJ B-O
outcome NOUN B-O
for ADP B-O
influenza NOUN B-O
. PUNCT B-O

Although SCONJ B-O
the DET B-O
Preferred PROPN B-LF
Reporting PROPN I-LF
Items PROPN I-LF
for ADP I-LF
Systematic ADJ I-LF
reviews NOUN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PUNCT I-LF
Analyses PROPN I-LF
( PUNCT B-O
PRISMA PROPN B-AC
) PUNCT B-O
guidelines NOUN B-O
have AUX B-O
been AUX B-O
critical ADJ B-O
to ADP B-O
the DET B-O
proper ADJ B-O
reporting VERB B-O
of ADP B-O
systematic ADJ B-O
reviews NOUN B-O
[ PUNCT B-O
7,8 NUM B-O
] PUNCT B-O
, PUNCT B-O
they PRON B-O
lack VERB B-O
specificity NOUN B-O
for ADP B-O
reporting VERB B-O
systematic ADJ B-O
reviews NOUN B-O
of ADP B-O
preclinical ADJ B-O
research NOUN B-O
. PUNCT B-O

Differing VERB B-O
in ADP B-O
allele NOUN B-O
frequency NOUN B-O
across ADP B-O
three NUM B-O
population NOUN B-O
comparisons NOUN B-O
and CCONJ B-O
associated VERB B-O
with ADP B-O
the DET B-O
abundance NOUN B-O
of ADP B-O
Clostridiales NOUN B-O
, NOUN B-O
the DET B-O
genetic ADJ B-O
variant NOUN B-O
rs7587067 NOUN B-O
has VERB B-O
a DET B-O
significantly ADV B-O
higher ADJ B-O
frequency NOUN B-O
in ADP B-O
African ADJ B-O
( PUNCT B-O
minor ADJ B-LF
allele NOUN I-LF
frequency NOUN I-LF
[ X B-O
MAF PROPN B-AC
] X B-O
= PUNCT B-O
0.802 NUM B-O
) PUNCT B-O
versus ADP B-O
East ADJ B-O
Asian ADJ B-O
( PUNCT B-O
MAF PROPN B-AC
= PUNCT B-O
0.190 NUM B-O
, NOUN B-O
FST PROPN B-AC
= PUNCT B-O
0.54 NUM B-O
, NOUN B-O
Chromosome NOUN B-O
= PUNCT B-O
98.7 NUM B-O
% PUNCT B-O
, NOUN B-O
Genome NOUN B-O
- PUNCT B-O
Wide ADJ B-O
= PUNCT B-O
98.9 NUM B-O
% PUNCT B-O
) PUNCT B-O
, NOUN B-O
admixed ADJ B-O
American PROPN B-O
( PUNCT B-O
MAF PROPN B-AC
= PUNCT B-O
0.278 NUM B-O
, NOUN B-O
FST PROPN B-AC
= PUNCT B-O
0.44 NUM B-O
, NOUN B-O
Chromosome NOUN B-O
= PUNCT B-O
99.0 NUM B-O
% PUNCT B-O
, NOUN B-O
Genome NOUN B-O
- PUNCT B-O
Wide ADJ B-O
= PUNCT B-O
99.1 NUM B-O
% PUNCT B-O
) PUNCT B-O
, NOUN B-O
and CCONJ B-O
European ADJ B-O
populations NOUN B-O
( PUNCT B-O
MAF PROPN B-AC
= PUNCT B-O
0.267 NUM B-O
, NOUN B-O
FST PROPN B-AC
= PUNCT B-O
0.45 NUM B-O
, NOUN B-O
Chromosome NOUN B-O
= PUNCT B-O
98.7.3 NUM B-O
% PUNCT B-O
, NOUN B-O
Genome NOUN B-O
- PUNCT B-O
Wide ADJ B-O
= PUNCT B-O
98.7 NUM B-O
% PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Utilizing VERB B-O
2 NUM B-O
bulk ADJ B-O
RNA-Seq PROPN B-AC
datasets NOUN B-O
( PUNCT B-O
GSE63142 NUM B-O
and CCONJ B-O
GSE130499 PROPN B-O
) PUNCT B-O
of ADP B-O
asthma NOUN B-O
patients NOUN B-O
compared VERB B-O
to ADP B-O
healthy ADJ B-O
controls NOUN B-O
, PUNCT B-O
we PRON B-O
identified VERB B-O
that SCONJ B-O
IRAK3 PROPN B-O
and CCONJ B-O
ADRB2 PROPN B-O
had VERB B-O
significantly ADV B-O
elevated VERB B-O
expression NOUN B-O
( PUNCT B-O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
[ X B-O
FDR PROPN B-AC
] X B-O
< ADP B-O
0.05 NUM B-O
) PUNCT B-O
in ADP B-O
asthma NOUN B-O
patients NOUN B-O
. PUNCT B-O

As ADP B-O
a DET B-O
robust ADJ B-O
fiduciary ADJ B-O
marker NOUN B-O
for ADP B-O
CCPs PROPN B-AC
, PUNCT B-O
clathrin PROPN B-LF
light PROPN I-LF
chain NOUN I-LF
a DET I-LF
( PUNCT B-O
CLCa PROPN B-AC
) PUNCT B-O
carrying VERB B-O
an DET B-O
N NOUN B-O
- PUNCT B-O
terminal ADJ B-O
SNAP PROPN B-O
- PUNCT B-O
fusion NOUN B-O
tag NOUN B-O
was AUX B-O
stably ADV B-O
introduced VERB B-O
in ADP B-O
parallel ADJ B-O
into ADP B-O
both DET B-O
cell NOUN B-O
lines NOUN B-O
via ADP B-O
a DET B-O
lentiviral ADJ B-O
vector NOUN B-O
with ADP B-O
puromycin NOUN B-O
selection NOUN B-O
of ADP B-O
SNAP PROPN B-O
- PUNCT B-O
CLCa PROPN B-AC
expressing VERB B-O
cells NOUN B-O
. PUNCT B-O

From ADP B-O
S6 PROPN B-O
Fig NOUN B-O
, PUNCT B-O
it PRON B-O
can AUX B-O
also ADV B-O
be AUX B-O
seen VERB B-O
that SCONJ B-O
upon SCONJ B-O
binding VERB B-O
to ADP B-O
dabrafenib NOUN B-O
, PUNCT B-O
radius NOUN B-LF
of ADP I-LF
gyration NOUN I-LF
value NOUN B-O
( PUNCT B-O
Rg PROPN B-AC
) PUNCT B-O
significantly ADV B-O
decreased VERB B-O
. PUNCT B-O

CHD PROPN B-AC
, PUNCT B-O
coronary ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
; PUNCT B-O
FMD PROPN B-AC
, PUNCT B-O
flow NOUN B-LF
- PUNCT I-LF
mediated VERB I-LF
dilation NOUN I-LF
; PUNCT B-O
HCAEC PROPN B-AC
, PUNCT B-O
human ADJ B-LF
coronary ADJ I-LF
artery NOUN I-LF
endothelial ADJ I-LF
cell NOUN I-LF
; PUNCT B-O
PCNA PROPN B-O
, PUNCT B-O
proliferating VERB B-O
cell NOUN B-O
nuclear ADJ B-O
antigen NOUN B-O
. PUNCT B-O

Previous ADJ B-O
connectivity NOUN B-O
studies NOUN B-O
using VERB B-O
EEG PROPN B-AC
have AUX B-O
found VERB B-O
synchronized VERB B-O
beta NOUN B-O
frequency NOUN B-O
oscillations NOUN B-O
in ADP B-O
the DET B-O
basal ADJ B-LF
ganglia NOUN I-LF
( PUNCT B-O
BG PROPN B-AC
) PUNCT B-O
including VERB B-O
cortical ADJ B-O
- PUNCT B-O
thalamic ADJ B-O
, PUNCT B-O
EGP NOUN B-O
/ SYM B-O
IGP NOUN B-O
- PUNCT B-O
thalamic ADJ B-O
, PUNCT B-O
cortical ADJ B-O
- PUNCT B-O
striatal ADJ B-O
, PUNCT B-O
striatal ADJ B-O
- PUNCT B-O
EGP NOUN B-O
/ SYM B-O
IGP NOUN B-O
and CCONJ B-O
cortical ADJ B-O
- PUNCT B-O
SN NOUN B-O
pars NOUN B-O
reticulata NOUN B-O
connections NOUN B-O
[ X B-O
68 NUM B-O
, PUNCT B-O
69 NUM B-O
] PUNCT B-O
indicating VERB B-O
increased VERB B-O
functional ADJ B-O
coupling NOUN B-O
between ADP B-O
these DET B-O
brain NOUN B-O
structures NOUN B-O
in ADP B-O
6-OHDA PROPN B-AC
rats NOUN B-O
. PUNCT B-O

DIC PROPN B-AC
, PUNCT B-O
differential ADJ B-LF
interference NOUN I-LF
contrast NOUN I-LF
; PUNCT B-O
dsRNA PROPN B-AC
, PUNCT B-O
double ADJ B-LF
- PUNCT I-LF
stranded ADJ I-LF
RNA NOUN I-LF
; PUNCT B-O
GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
Oo NOUN B-O
, PUNCT B-O
oocyte NOUN B-O
; PUNCT B-O
Sp NOUN B-O
, PUNCT B-O
sperm NOUN B-O
; PUNCT B-O
RNAi PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT B-O
RT PROPN B-AC
, PUNCT B-O
Reverse ADJ B-LF
transcription NOUN I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
. PUNCT B-O

Population NOUN B-O
density NOUN B-O
is AUX B-O
measured VERB B-O
using VERB B-O
light NOUN B-O
scattering NOUN B-O
( PUNCT B-O
optical ADJ B-LF
density NOUN I-LF
[ PUNCT B-O
OD PROPN B-AC
] PUNCT B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
drug NOUN B-O
concentration NOUN B-O
can AUX B-O
be AUX B-O
adjusted VERB B-O
in ADP B-O
real ADJ B-O
time NOUN B-O
in ADP B-O
response NOUN B-O
to ADP B-O
population NOUN B-O
dynamics NOUN B-O
or CCONJ B-O
predetermined VERB B-O
protocols NOUN B-O
( PUNCT B-O
S1 NUM B-O
Fig NOUN B-O
) PUNCT B-O
. PUNCT B-O

Esophageal ADJ B-LF
adenocarcinoma NOUN I-LF
( PUNCT B-O
EAC PROPN B-AC
) PUNCT B-O
is AUX B-O
predominantly ADV B-O
a DET B-O
disease NOUN B-O
of ADP B-O
the DET B-O
distal ADJ B-O
esophagus NOUN B-O
and CCONJ B-O
gastroesophageal ADJ B-O
junction NOUN B-O
. PUNCT B-O

Atherosclerosis NOUN B-O
is AUX B-O
the DET B-O
major ADJ B-O
cause NOUN B-O
for ADP B-O
developing VERB B-O
vascular ADJ B-O
events NOUN B-O
[ PUNCT B-O
2,13–18 NUM B-O
] PUNCT B-O
including VERB B-O
ischemic ADJ B-O
heart NOUN B-O
disease NOUN B-O
, PUNCT B-O
heart NOUN B-O
failure NOUN B-O
, PUNCT B-O
stroke NOUN B-O
, PUNCT B-O
and CCONJ B-O
peripheral ADJ B-LF
arterial ADJ I-LF
occlusive ADJ I-LF
disease NOUN I-LF
( PUNCT B-O
PAOD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

A DET B-O
genetic ADJ B-O
manipulation NOUN B-O
study NOUN B-O
comparing VERB B-O
double ADJ B-O
( PUNCT B-O
apolipoprotein NOUN B-O
E NOUN B-O
and CCONJ B-O
eNOS PROPN B-AC
) PUNCT B-O
knockout NOUN B-O
with ADP B-O
single ADJ B-O
( PUNCT B-O
apolipoprotein NOUN B-O
E NOUN B-O
) PUNCT B-O
knockout NOUN B-O
model NOUN B-O
demonstrate VERB B-O
that SCONJ B-O
eNOS PROPN B-AC
deficiency NOUN B-O
increases VERB B-O
atherosclerosis NOUN B-O
in ADP B-O
Western ADJ B-O
- PUNCT B-O
type NOUN B-O
diet NOUN B-O
- PUNCT B-O
fed VERB B-O
single ADJ B-O
( PUNCT B-O
apolipoprotein NOUN B-O
E NOUN B-O
) PUNCT B-O
knockout NOUN B-O
mice NOUN B-O
and CCONJ B-O
introduces VERB B-O
an DET B-O
array NOUN B-O
of ADP B-O
cardiovascular ADJ B-O
complications NOUN B-O
, PUNCT B-O
including VERB B-O
myocardial ADJ B-O
infarction NOUN B-O
, PUNCT B-O
heart NOUN B-O
failure NOUN B-O
, PUNCT B-O
and CCONJ B-O
spontaneous ADJ B-O
aortic ADJ B-O
aneurysm NOUN B-O
and CCONJ B-O
dissection NOUN B-O
[ PUNCT B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

Five NUM B-O
different ADJ B-O
tissues NOUN B-O
and CCONJ B-O
organs NOUN B-O
of ADP B-O
P. NOUN B-O
tepidariorum NOUN B-O
– PUNCT B-O
the DET B-O
midgut NOUN B-LF
glands NOUN I-LF
with ADP I-LF
midgut NOUN I-LF
( PUNCT B-O
MG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
neuroendocrine ADJ B-LF
and CCONJ I-LF
nervous ADJ I-LF
system NOUN I-LF
( PUNCT B-O
NS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
ovaries NOUN B-LF
( PUNCT B-O
OV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
hindgut NOUN B-LF
( PUNCT B-O
HG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
integument NOUN B-LF
( PUNCT B-O
INT)–were PROPN B-AC
used VERB B-O
for ADP B-O
the DET B-O
analysis NOUN B-O
. PUNCT B-O

SDMA PROPN B-AC
concentrations NOUN B-O
were AUX B-O
determined VERB B-O
using VERB B-O
liquid NOUN B-LF
chromatography NOUN I-LF
- PUNCT I-LF
mass NOUN I-LF
spectroscopy NOUN I-LF
( PUNCT B-O
LC-MS PROPN B-AC
) PUNCT B-O
as SCONJ B-O
previously ADV B-O
described VERB B-O
[ PUNCT B-O
6 NUM B-O
] PUNCT B-O
. PUNCT B-O

BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
HR PROPN B-AC
, PUNCT B-O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
SD PROPN B-AC
, PUNCT B-O
standard ADJ B-LF
deviation NOUN I-LF
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
RE PROPN B-AC
-ZINB PROPN B-AC
, PUNCT B-O
random ADJ B-LF
- PUNCT I-LF
effects NOUN I-LF
zero NUM B-LF
- PUNCT I-LF
inflated VERB I-LF
negative ADJ I-LF
binomial NOUN I-LF
; PUNCT B-O
IRR PROPN B-AC
, PUNCT B-O
incidence NOUN B-LF
rate NOUN I-LF
ratio NOUN I-LF
; PUNCT B-O
CI NOUN B-O
, PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
; PUNCT B-O
OR PROPN B-AC
, PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
LLIN PROPN B-AC
, PUNCT B-O
long ADV B-LF
- PUNCT I-LF
lasting VERB I-LF
insecticidal ADJ I-LF
bed NOUN I-LF
net NOUN I-LF
; PUNCT B-O
IRS PROPN B-AC
, PUNCT B-O
indoor ADJ B-LF
residual ADJ I-LF
spraying NOUN I-LF
. PUNCT B-O

Trajectories NOUN B-O
of ADP B-O
HAQ PROPN B-AC
scores NOUN B-O
over ADP B-O
follow NOUN B-O
- PUNCT B-O
up NOUN B-O
were AUX B-O
assessed VERB B-O
using VERB B-O
latent ADJ B-LF
class NOUN I-LF
growth NOUN I-LF
models NOUN I-LF
( PUNCT B-O
LCGMs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
multivariate ADJ B-O
logistic ADJ B-O
regression NOUN B-O
model NOUN B-O
was AUX B-O
fit ADJ B-O
to PART B-O
determine VERB B-O
the DET B-O
association NOUN B-O
between ADP B-O
the DET B-O
patient NOUN B-O
specific ADJ B-O
factors NOUN B-O
and CCONJ B-O
the DET B-O
occurrence NOUN B-O
of ADP B-O
the DET B-O
different ADJ B-O
types NOUN B-O
of ADP B-O
DTPs PROPN B-AC
. PUNCT B-O

Comparison NOUN B-O
of ADP B-O
factors NOUN B-O
contributing VERB B-O
for ADP B-O
drug NOUN B-LF
therapy NOUN I-LF
problems NOUN I-LF
were AUX B-O
shown VERB B-O
using VERB B-O
odd ADJ B-O
ratios NOUN B-O
. PUNCT B-O

Because SCONJ B-O
loss NOUN B-O
of ADP B-O
CG6866 NOUN B-O
function NOUN B-O
de VERB B-O
- PUNCT B-O
silences VERB B-O
both CCONJ B-O
endogenous ADJ B-O
silencing NOUN B-O
and CCONJ B-O
reporter NOUN B-O
expression NOUN B-O
in ADP B-O
vivo ADV B-O
( PUNCT B-O
below ADV B-O
) PUNCT B-O
, PUNCT B-O
we PRON B-O
named VERB B-O
the DET B-O
gene NOUN B-O
loquacious ADJ B-O
( PUNCT B-O
loqs PROPN B-O
) PUNCT B-O
. PUNCT B-O

loqs PROPN B-O
is AUX B-O
located VERB B-O
on ADP B-O
the DET B-O
left ADJ B-O
arm NOUN B-O
of ADP B-O
Chromosome NOUN B-O
2 NUM B-O
at ADP B-O
polytene NOUN B-O
band NOUN B-O
34B9 NUM B-O
. PUNCT B-O

loqs PROPN B-O
produces VERB B-O
at ADP B-O
least ADV B-O
three NUM B-O
different ADJ B-O
mRNA NOUN B-O
isoforms NOUN B-O
through ADP B-O
alternative ADJ B-O
splicing NOUN B-O
( PUNCT B-O
Figure PROPN B-O
1B NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
shortest ADJ B-O
transcript NOUN B-O
, PUNCT B-O
loqs PROPN B-O
RNA NOUN B-LF
splice NOUN I-LF
variant NOUN I-LF
A PROPN I-LF
( PUNCT B-O
RA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
encodes VERB B-O
a DET B-O
419 NUM B-O
- PUNCT B-O
amino NOUN B-O
- PUNCT B-O
acid NOUN B-O
protein NOUN B-O
, PUNCT B-O
Loqs PROPN B-O
protein NOUN B-LF
isoform NOUN I-LF
A PROPN I-LF
( PUNCT B-O
PA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
with ADP B-O
a DET B-O
predicted VERB B-O
molecular ADJ B-O
mass NOUN B-O
of ADP B-O
45 NUM B-O
kDa NOUN B-O
. PUNCT B-O

The DET B-O
transcript NOUN B-O
loqs PROPN B-O
RNA NOUN B-LF
splice NOUN I-LF
variant NOUN I-LF
B PROPN I-LF
( PUNCT B-O
RB PROPN B-AC
) PUNCT B-O
contains VERB B-O
one NUM B-O
additional ADJ B-O
exon NOUN B-O
and CCONJ B-O
encodes VERB B-O
a DET B-O
protein NOUN B-O
of ADP B-O
465 NUM B-O
amino NOUN B-O
acids NOUN B-O
, PUNCT B-O
Loqs PROPN B-O
protein NOUN B-LF
isoform NOUN I-LF
B PROPN I-LF
( PUNCT B-O
PB PROPN B-AC
) PUNCT B-O
, PUNCT B-O
with ADP B-O
a DET B-O
predicted VERB B-O
molecular ADJ B-O
mass NOUN B-O
of ADP B-O
50 NUM B-O
kDa NOUN B-O
. PUNCT B-O

These DET B-O
two NUM B-O
mRNA NOUN B-O
species NOUN B-O
were AUX B-O
identified VERB B-O
as ADP B-O
cDNAs NOUN B-O
in ADP B-O
the DET B-O
Drosophila PROPN B-O
genome NOUN B-O
sequencing NOUN B-O
project NOUN B-O
and CCONJ B-O
annotated VERB B-O
in ADP B-O
FlyBase PROPN B-O
[ X B-O
38 NUM B-O
] X B-O
among ADP B-O
the DET B-O
Drosophila PROPN B-O
proteins NOUN B-O
that PRON B-O
contain VERB B-O
dsRBDs PROPN B-AC
. PUNCT B-O

Using VERB B-O
non ADJ B-O
- PUNCT B-O
quantitative ADJ B-O
RT NOUN B-O
- PUNCT B-O
PCR NOUN B-O
, PUNCT B-O
we PRON B-O
detected VERB B-O
a DET B-O
third ADJ B-O
splice NOUN B-O
variant NOUN B-O
, PUNCT B-O
loqs PROPN B-O
RNA NOUN B-LF
splice NOUN I-LF
variant NOUN I-LF
C PROPN I-LF
( PUNCT B-O
RC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
in ADP B-O
which PRON B-O
an DET B-O
alternative ADJ B-O
splice NOUN B-O
acceptor NOUN B-O
site NOUN B-O
for ADP B-O
exon NOUN B-O
4 NUM B-O
is AUX B-O
used VERB B-O
( PUNCT B-O
Figure PROPN B-O
1B NUM B-O
, PUNCT B-O
C PROPN B-O
, PUNCT B-O
and CCONJ B-O
D NOUN B-O
) PUNCT B-O
. PUNCT B-O

Use NOUN B-O
of ADP B-O
the DET B-O
alternative ADJ B-O
splice NOUN B-O
site NOUN B-O
creates VERB B-O
a DET B-O
5′-extended ADJ B-O
fourth ADJ B-O
exon NOUN B-O
and CCONJ B-O
changes VERB B-O
the DET B-O
reading NOUN B-O
frame NOUN B-O
, PUNCT B-O
resulting VERB B-O
in ADP B-O
a DET B-O
truncated VERB B-O
protein NOUN B-O
, PUNCT B-O
Loqs PROPN B-O
protein NOUN B-LF
isoform NOUN I-LF
C PROPN I-LF
( PUNCT B-O
PC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
383 NUM B-O
amino NOUN B-O
acids NOUN B-O
long ADJ B-O
( PUNCT B-O
Figure PROPN B-O
1C NUM B-O
) PUNCT B-O
. PUNCT B-O

Loqs PROPN B-O
PC PROPN B-AC
has VERB B-O
a DET B-O
predicted VERB B-O
molecular ADJ B-O
mass NOUN B-O
of ADP B-O
41 NUM B-O
kDa NOUN B-O
and CCONJ B-O
lacks VERB B-O
the DET B-O
entire ADJ B-O
third ADJ B-O
dsRBD PROPN B-AC
of ADP B-O
Loqs PROPN B-O
PA PROPN B-AC
and CCONJ B-O
PB PROPN B-AC
( PUNCT B-O
Figure PROPN B-O
1B NUM B-O
) PUNCT B-O
. PUNCT B-O

loqs PROPN B-O
RA PROPN B-AC
is AUX B-O
the DET B-O
predominant ADJ B-O
mRNA NOUN B-O
species NOUN B-O
in ADP B-O
dissected ADJ B-O
testes NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
loqs PROPN B-O
RB PROPN B-AC
is AUX B-O
the DET B-O
most ADV B-O
abundant ADJ B-O
species NOUN B-O
in ADP B-O
ovaries NOUN B-O
. PUNCT B-O

Autotaxin PROPN B-LF
( PUNCT B-O
ATX PROPN B-AC
) PUNCT B-O
has VERB B-O
a DET B-O
profibrotic ADJ B-O
effect NOUN B-O
resulting VERB B-O
from ADP B-O
lysophosphatidic ADJ B-O
acid NOUN B-O
activity NOUN B-O
. PUNCT B-O

Only ADV B-O
markers NOUN B-O
with ADP B-O
known VERB B-O
map NOUN B-O
positions NOUN B-O
were AUX B-O
used VERB B-O
to PART B-O
perform VERB B-O
linkage NOUN B-LF
disequilibrium NOUN I-LF
( PUNCT B-O
LD PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
with ADP B-O
TASSEL PROPN B-O
3.0 NUM B-O
[ PUNCT B-O
37 NUM B-O
] PUNCT B-O
. PUNCT B-O

Response NOUN B-O
: PUNCT B-O
Sucrose NOUN B-O
in ADP B-O
full ADJ B-O
form NOUN B-O
in ADP B-O
heading NOUN B-O
or CCONJ B-O
subheadings NOUN B-O
has AUX B-O
been AUX B-O
mentioned VERB B-O
, PUNCT B-O
and CCONJ B-O
“ PUNCT B-O
Determination PROPN B-O
of ADP B-O
Chl PROPN B-AC
Precursors NOUN B-O
” PUNCT B-O
has AUX B-O
been AUX B-O
replaced VERB B-O
by ADP B-O
“ PUNCT B-O
Determination PROPN B-O
of ADP B-O
Chlorophyll PROPN B-LF
Precursors NOUN B-O
” PUNCT B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
was AUX B-O
approved VERB B-O
by ADP B-O
the DET B-O
institutional ADJ B-O
review NOUN B-O
boards NOUN B-O
of ADP B-O
Kyoto PROPN B-LF
Prefectural PROPN I-LF
University PROPN I-LF
of ADP I-LF
Medicine PROPN I-LF
( PUNCT B-O
KPUM PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
National PROPN B-O
Institute PROPN B-O
of ADP B-O
Health PROPN B-O
Sciences PROPN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
ITH PROPN B-AC
( PUNCT B-O
intra ADJ B-LF
- PUNCT I-LF
tumour ADJ I-LF
heterogeneity NOUN I-LF
) PUNCT B-O
, PUNCT B-O
OC PROPN B-AC
( PUNCT B-O
ovarian ADJ B-O
carcinoma NOUN B-O
) PUNCT B-O
, PUNCT B-O
BRCA PROPN B-AC
( PUNCT B-O
breast ADJ B-LF
cancer NOUN I-LF
invasive ADJ I-LF
carcinoma NOUN I-LF
) PUNCT B-O
. PUNCT B-O

Data NOUN B-O
are AUX B-O
available ADJ B-O
from ADP B-O
the DET B-O
Ethical PROPN B-O
Review PROPN B-O
Committee PROPN B-O
and/or CCONJ B-O
Research PROPN B-O
Administration PROPN B-O
of ADP B-O
International PROPN B-LF
Centre PROPN I-LF
for ADP I-LF
Diarrhoeal PROPN I-LF
Disease PROPN I-LF
Research PROPN I-LF
, X I-LF
Bangladesh PROPN I-LF
( PUNCT B-O
icddr,b PROPN B-AC
) PUNCT B-O
for ADP B-O
researchers NOUN B-O
who PRON B-O
meet VERB B-O
the DET B-O
criteria NOUN B-O
for ADP B-O
access NOUN B-O
to ADP B-O
confidential ADJ B-O
data NOUN B-O
. PUNCT B-O

Results NOUN B-O
are AUX B-O
presented VERB B-O
as ADP B-O
adjusted VERB B-LF
odds NOUN I-LF
ratios NOUN I-LF
( PUNCT B-O
aOR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
) PUNCT B-O
and CCONJ B-O
their PRON B-O
p NOUN B-O
- PUNCT B-O
values NOUN B-O
. PUNCT B-O

( PUNCT B-O
A X B-O
) PUNCT B-O
Gene NOUN B-O
induction NOUN B-O
determined VERB B-O
by ADP B-O
qRT-PCR PROPN B-AC
with ADP B-O
parental ADJ B-O
( PUNCT B-O
S2-/- PROPN B-O
) PUNCT B-O
and CCONJ B-O
stably ADV B-O
STAT2 PROPN B-O
- PUNCT B-O
reconstituted VERB B-O
( PUNCT B-O
S2 PROPN B-O
WT PROPN B-AC
or CCONJ B-O
S2 PROPN B-O
L82A NOUN B-O
) PUNCT B-O
human ADJ B-O
U6A PROPN B-O
cells NOUN B-O
after ADP B-O
treatment NOUN B-O
with ADP B-O
IFN PROPN B-AC
- PUNCT B-O
β PUNCT B-O
( PUNCT B-O
500 NUM B-O
U NOUN B-O
/ NOUN B-O
ml NOUN B-O
) PUNCT B-O
for ADP B-O
4 NUM B-O
h. NOUN B-O
( PUNCT B-O
B X B-O
) PUNCT B-O
STAT1 PROPN B-O
- PUNCT B-O
CFP PROPN B-AC
and CCONJ B-O
YFP PROPN B-AC
- PUNCT B-O
tagged VERB B-O
wild ADJ B-LF
type NOUN I-LF
( PUNCT B-O
top ADJ B-O
panels NOUN B-O
) PUNCT B-O
or CCONJ B-O
L82A NOUN B-O
mutated VERB B-O
STAT2 PROPN B-O
( PUNCT B-O
bottom ADJ B-O
panels NOUN B-O
) PUNCT B-O
were AUX B-O
co VERB B-O
- PUNCT B-O
expressed VERB B-O
in ADP B-O
HeLa PROPN B-O
cells NOUN B-O
and CCONJ B-O
their PRON B-O
subcellular ADJ B-O
localization NOUN B-O
was AUX B-O
observed VERB B-O
by ADP B-O
deconvolution NOUN B-O
microscopy NOUN B-O
after ADP B-O
1 NUM B-O
h NOUN B-O
in ADP B-O
the DET B-O
presence NOUN B-O
of ADP B-O
IFN PROPN B-AC
- PUNCT B-O
β PUNCT B-O
. PUNCT B-O

1Treatments NOUN B-O
: PUNCT B-O
CON PROPN B-AC
= PUNCT B-O
Piglets NOUN B-O
drenched VERB B-O
with ADP B-O
2 NUM B-O
mL NOUN B-O
tap NOUN B-O
water NOUN B-O
until ADP B-O
d NOUN B-O
7 NUM B-O
; PUNCT B-O
T1 NOUN B-O
= PUNCT B-O
Piglets NOUN B-O
drenched VERB B-O
with ADP B-O
1 NUM B-O
g NOUN B-O
short ADJ B-LF
- PUNCT I-LF
chain NOUN I-LF
fructo NOUN I-LF
- PUNCT I-LF
oligosaccharides NOUN I-LF
( PUNCT B-O
scFOS PROPN B-AC
, PUNCT B-O
Profeed PROPN B-O
P95 PROPN B-O
, PUNCT B-O
Beghin PROPN B-O
- PUNCT B-O
Meiji PROPN B-O
) PUNCT B-O
dissolved VERB B-O
in ADP B-O
2 NUM B-O
mL NOUN B-O
tap NOUN B-O
water NOUN B-O
until ADP B-O
d NOUN B-O
7 NUM B-O
; PUNCT B-O
T2 NOUN B-O
= PUNCT B-O
Piglets NOUN B-O
drenched VERB B-O
with ADP B-O
1 NUM B-O
g NOUN B-O
scFOS PROPN B-AC
dissolved VERB B-O
in ADP B-O
2 NUM B-O
mL NOUN B-O
tap NOUN B-O
water NOUN B-O
until ADP B-O
d NOUN B-O
21.5 NUM B-O
( PUNCT B-O
weaning NOUN B-O
age NOUN B-O
) PUNCT B-O
. PUNCT B-O

Safety NOUN B-O
assessments NOUN B-O
were AUX B-O
performed VERB B-O
in ADP B-O
a DET B-O
standardized ADJ B-O
method NOUN B-O
at ADP B-O
each DET B-O
study NOUN B-O
visit NOUN B-O
and CCONJ B-O
included VERB B-O
the DET B-O
evaluation NOUN B-O
of ADP B-O
adverse ADJ B-LF
events NOUN I-LF
( PUNCT B-O
AEs PROPN B-AC
): PUNCT B-O
serious ADJ B-O
AEs PROPN B-AC
( PUNCT B-O
SAEs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
severe ADJ B-O
AEs PROPN B-AC
, PUNCT B-O
treatment NOUN B-O
- PUNCT B-O
related VERB B-O
AEs PROPN B-AC
, PUNCT B-O
procedure NOUN B-O
- PUNCT B-O
related VERB B-O
AEs PROPN B-AC
( PUNCT B-O
i.e. X B-O
The DET B-O
second ADJ B-O
objective NOUN B-O
was AUX B-O
to PART B-O
evaluate VERB B-O
the DET B-O
utility NOUN B-O
of ADP B-O
‘ PUNCT B-O
TB PROPN B-AC
Transport NOUN B-O
’ PUNCT B-O
( PUNCT B-O
containing VERB B-O
Trans-Filter PROPN B-AC
) PUNCT B-O
and CCONJ B-O
‘ PUNCT B-O
TB PROPN B-AC
DNA NOUN B-O
Extraction NOUN B-O
’ PUNCT B-O
kits NOUN B-O
for ADP B-O
sputum NOUN B-O
transport NOUN B-O
, PUNCT B-O
tuberculosis NOUN B-LF
M.tuberculosis PROPN B-AC
DNA NOUN B-O
isolation NOUN B-O
and CCONJ B-O
Mol-DST PROPN B-AC
assay NOUN B-O
, PUNCT B-O
taking VERB B-O
phenotypic ADJ B-O
DST NOUN B-O
as ADP B-O
the DET B-O
reference NOUN B-O
standard NOUN B-O
. PUNCT B-O

We PRON B-O
here ADV B-O
show VERB B-O
that SCONJ B-O
cell NOUN B-O
- PUNCT B-O
type NOUN B-O
– AUX B-O
specific ADJ B-O
reduction NOUN B-O
of ADP B-O
cyclin NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
kinase NOUN I-LF
5 NUM I-LF
( PUNCT B-O
cdk5 PROPN B-AC
) PUNCT B-O
activity NOUN B-O
in ADP B-O
newborn ADJ B-O
neurons NOUN B-O
results VERB B-O
in ADP B-O
impaired VERB B-O
neuronal ADJ B-O
migration NOUN B-O
and CCONJ B-O
leads VERB B-O
to ADP B-O
the DET B-O
extension NOUN B-O
of ADP B-O
incorrectly ADV B-O
targeted VERB B-O
neuronal ADJ B-O
processes NOUN B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
we PRON B-O
performed VERB B-O
disuccinimidyl NOUN B-LF
sulfoxide NOUN I-LF
( PUNCT B-O
DSSO PROPN B-AC
: PUNCT B-O
a DET B-O
mass NOUN B-LF
spectrometry NOUN I-LF
- PUNCT B-O
cleavable ADJ B-O
crosslinker NOUN B-O
) PUNCT B-O
crosslinking NOUN B-O
of ADP B-O
kindlin-3 NOUN B-O
monomer NOUN B-O
and CCONJ B-O
trimer NOUN B-O
followed VERB B-O
by ADP B-O
analytical ADJ B-O
gel NOUN B-O
filtration NOUN B-O
and CCONJ B-O
mass NOUN B-LF
spectrometry NOUN I-LF
( PUNCT B-O
MS PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
ART PROPN B-AC
, PUNCT B-O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
, PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
HAZ PROPN B-AC
, PUNCT B-O
WHO PROPN B-AC
height NOUN B-O
- PUNCT B-O
for ADP B-O
- PUNCT B-O
age NOUN B-O
Z NOUN B-O
- PUNCT B-O
score NOUN B-O
; PUNCT B-O
IQR PROPN B-AC
, PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
; PUNCT B-O
LTFU PROPN B-AC
, PUNCT B-O
loss NOUN B-O
to PART B-O
follow VERB B-O
- PUNCT B-O
up ADP B-O
. PUNCT B-O

Since SCONJ B-O
fructose NOUN B-O
metabolism NOUN B-O
is VERB B-O
insulin NOUN B-O
- PUNCT B-O
independent ADJ B-O
[ PUNCT B-O
2 X B-O
] PUNCT B-O
, PUNCT B-O
there PRON B-O
is VERB B-O
less ADJ B-O
uptake NOUN B-O
and CCONJ B-O
catabolism NOUN B-O
of ADP B-O
triglyceride NOUN B-LF
( PUNCT B-O
TG)-rich PROPN B-AC
lipoproteins NOUN B-O
by ADP B-O
tissues NOUN B-O
, PUNCT B-O
ultimately ADV B-O
resulting VERB B-O
in ADP B-O
increased VERB B-O
postprandial ADJ B-O
plasma NOUN B-O
TG PROPN B-AC
levels NOUN B-O
[ PUNCT B-O
8 NUM B-O
] PUNCT B-O
. PUNCT B-O

CONSORT PROPN B-AC
has AUX B-O
been AUX B-O
endorsed VERB B-O
by ADP B-O
the DET B-O
World PROPN B-LF
Association PROPN I-LF
of ADP I-LF
Medical PROPN I-LF
Editors PROPN I-LF
( PUNCT B-O
WAME PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
International PROPN B-LF
Committee PROPN I-LF
of ADP I-LF
Medical PROPN I-LF
Journal PROPN I-LF
Editors PROPN I-LF
( PUNCT B-O
ICMJE PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
Council PROPN B-LF
of ADP I-LF
Science PROPN I-LF
Editors PROPN I-LF
( PUNCT B-O
CSE PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Currently ADV B-O
, PUNCT B-O
however ADV B-O
, PUNCT B-O
the DET B-O
CONSORT PROPN B-AC
Statement PROPN B-O
provides VERB B-O
limited ADJ B-O
guidance NOUN B-O
about ADP B-O
preparing VERB B-O
abstracts NOUN B-O
and CCONJ B-O
, PUNCT B-O
while SCONJ B-O
it PRON B-O
encourages VERB B-O
the DET B-O
use NOUN B-O
of ADP B-O
a DET B-O
structured ADJ B-O
format NOUN B-O
, PUNCT B-O
this PRON B-O
is AUX B-O
not PART B-O
a DET B-O
formal ADJ B-O
requirement NOUN B-O
. PUNCT B-O

To PART B-O
correlate VERB B-O
responsiveness NOUN B-O
of ADP B-O
ccRCC PROPN B-AC
cell NOUN B-O
lines NOUN B-O
to ADP B-O
established VERB B-O
forms NOUN B-O
of ADP B-O
treatments NOUN B-O
with ADP B-O
extent NOUN B-O
of ADP B-O
genomic ADJ B-O
aberrations NOUN B-O
, PUNCT B-O
we PRON B-O
analyzed VERB B-O
a DET B-O
subset NOUN B-O
of ADP B-O
malignant ADJ B-O
clear ADJ B-O
cell NOUN B-O
renal ADJ B-O
cell NOUN B-O
lines NOUN B-O
, PUNCT B-O
via ADP B-O
The DET B-LF
Cancer PROPN I-LF
Genome PROPN I-LF
Atlas PROPN I-LF
( PUNCT B-O
TCGA PROPN B-AC
: PUNCT B-O
[ X B-O
28 NUM B-O
, PUNCT B-O
29 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Data NOUN B-O
are AUX B-O
means NOUN B-O
± SYM B-O
s.d NOUN B-O
. PUNCT B-O

( PUNCT B-O
* PUNCT B-O
p NOUN B-O
= X B-O
0.06 NUM B-O
, PUNCT B-O
* PUNCT B-O
* PUNCT B-O
p NOUN B-O
= X B-O
0.0012 NUM B-O
, PUNCT B-O
* PUNCT B-O
* PUNCT B-O
* PUNCT B-O
p NOUN B-O
= X B-O
0.0005 NUM B-O
) PUNCT B-O
. PUNCT B-O

β PUNCT B-O
- PUNCT B-O
Galactosidase NOUN B-O
( PUNCT B-O
puc-lacZ PROPN B-AC
) PUNCT B-O
, PUNCT B-O
purple ADJ B-O
; PUNCT B-O
Ptc PROPN B-AC
, PUNCT B-O
green NOUN B-O
; PUNCT B-O
DAPI NOUN B-O
, PUNCT B-O
turquoise NOUN B-O
; PUNCT B-O
En PROPN B-AC
, PUNCT B-O
red NOUN B-O
. PUNCT B-O

( PUNCT B-O
A NOUN B-O
– PUNCT B-O
C PROPN B-O
) PUNCT B-O
( PUNCT B-O
right ADJ B-O
panels NOUN B-O
) PUNCT B-O
Scheme NOUN B-O
of ADP B-O
the DET B-O
phenotype NOUN B-O
and CCONJ B-O
expression NOUN B-O
patterns NOUN B-O
of ADP B-O
Wg PROPN B-AC
and CCONJ B-O
En PROPN B-AC
; PUNCT B-O
PS PROPN B-AC
is AUX B-O
for ADP B-O
parasegment NOUN B-LF
boundary NOUN B-O
and CCONJ B-O
S PROPN B-O
for ADP B-O
segment NOUN B-O
boundary NOUN B-O
. PUNCT B-O

( PUNCT B-O
D X B-O
) PUNCT B-O
Model NOUN B-O
of ADP B-O
JNK PROPN B-O
induced VERB B-O
reprogramming NOUN B-O
at ADP B-O
the DET B-O
segment NOUN B-O
boundary NOUN B-O
and CCONJ B-O
Wg PROPN B-AC
inhibition NOUN B-O
at ADP B-O
the DET B-O
parasegment NOUN B-LF
boundary NOUN B-O
. PUNCT B-O

More ADV B-O
recently ADV B-O
, PUNCT B-O
several ADJ B-O
PCP PROPN B-AC
pathway NOUN B-O
components NOUN B-O
, PUNCT B-O
like ADP B-O
the DET B-O
Wnt NOUN B-O
receptor NOUN B-O
Frizzled PROPN B-LF
( PUNCT B-O
Fz PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Flamingo PROPN B-LF
( PUNCT B-O
Fmi PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Strabismus PROPN B-O
( PUNCT B-O
Stbm PROPN B-O
or CCONJ B-O
Vang PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
Dsh PROPN B-AC
, PUNCT B-O
have AUX B-O
been AUX B-O
shown VERB B-O
to PART B-O
play VERB B-O
a DET B-O
role NOUN B-O
in ADP B-O
the DET B-O
correct ADJ B-O
targeting NOUN B-O
and CCONJ B-O
bifurcation NOUN B-O
of ADP B-O
MB PROPN B-AC
axons NOUN B-O
[ PUNCT B-O
4],[30],[31 NUM B-O
] PUNCT B-O
. PUNCT B-O

Error NOUN B-O
bars NOUN B-O
denote VERB B-O
standard ADJ B-LF
errors NOUN I-LF
of ADP I-LF
means NOUN I-LF
( PUNCT B-O
SEM PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Underlying VERB B-O
data NOUN B-O
can AUX B-O
be AUX B-O
found VERB B-O
in ADP B-O
S1 PROPN B-O
Data PROPN B-O
. PUNCT B-O

Thus ADV B-O
, PUNCT B-O
we PRON B-O
here ADV B-O
decided VERB B-O
to PART B-O
perform VERB B-O
all DET B-O
reactions NOUN B-O
in ADP B-O
DMSO NOUN B-O
- PUNCT B-O
free ADJ B-O
aqueous ADJ B-O
buffers NOUN B-O
using VERB B-O
N NOUN B-LF
, PUNCT I-LF
N NOUN I-LF
, PUNCT I-LF
N’,N’,N”-pentamethyldiethylenetriamine NOUN I-LF
( PUNCT B-O
PMDETA PROPN B-AC
) PUNCT B-O
as ADP B-O
a DET B-O
Cu NOUN B-O
( PUNCT B-O
I NOUN B-O
) PUNCT B-O
stabilizing VERB B-O
agent NOUN B-O
for ADP B-O
the DET B-O
conjugation NOUN B-O
of ADP B-O
the DET B-O
RNA NOUN B-O
aptamer NOUN B-O
Gint4.T PROPN B-O
to PART B-O
MP PROPN B-AC
. PUNCT B-O

The DET B-O
advantage NOUN B-O
of ADP B-O
PMDETA PROPN B-AC
is AUX B-O
its PRON B-O
water NOUN B-O
solubility NOUN B-O
and CCONJ B-O
ease NOUN B-O
to PART B-O
separate VERB B-O
from ADP B-O
the DET B-O
reaction NOUN B-O
mixture NOUN B-O
upon SCONJ B-O
purification NOUN B-O
of ADP B-O
the DET B-O
conjugate NOUN B-O
[ PUNCT B-O
27 NUM B-O
] PUNCT B-O
. PUNCT B-O

Human ADJ B-LF
papillomavirus NOUN I-LF
( PUNCT B-O
HPV PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
name NOUN B-O
of ADP B-O
a DET B-O
group NOUN B-O
of ADP B-O
viruses NOUN B-O
that PRON B-O
includes VERB B-O
more ADJ B-O
than ADP B-O
100 NUM B-O
different ADJ B-O
strains NOUN B-O
or CCONJ B-O
types NOUN B-O
; PUNCT B-O
more ADJ B-O
than ADP B-O
30 NUM B-O
of ADP B-O
these DET B-O
viruses NOUN B-O
are AUX B-O
sexually ADV B-O
transmitted VERB B-O
. PUNCT B-O

From ADP B-O
those DET B-O
predictive ADJ B-O
models NOUN B-O
the DET B-O
performance NOUN B-O
( PUNCT B-O
i.e. X B-O
, PUNCT B-O
ROCAUC PROPN B-AC
; PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
, PUNCT B-O
CI PROPN B-AC
) PUNCT B-O
for ADP B-O
classifying VERB B-O
the DET B-O
input NOUN B-O
phenotypic ADJ B-O
groups NOUN B-O
( PUNCT B-O
e.g. X B-O
, PUNCT B-O
cases NOUN B-O
versus ADP B-O
controls NOUN B-O
) PUNCT B-O
are AUX B-O
provided VERB B-O
. PUNCT B-O

Flow NOUN B-O
cytometry NOUN B-O
analysis NOUN B-O
of ADP B-O
uterine ADJ B-O
implantation NOUN B-O
sites NOUN B-O
following VERB B-O
removal NOUN B-O
of ADP B-O
the DET B-O
placenta NOUN B-O
/ SYM B-O
embryo NOUN B-O
demonstrated VERB B-O
that SCONJ B-O
the DET B-O
percentage NOUN B-O
of ADP B-O
BM PROPN B-AC
- NOUN B-O
derived VERB B-O
GFP+ PROPN B-AC
cells NOUN B-O
in ADP B-O
the DET B-O
implantation NOUN B-O
site NOUN B-O
increased VERB B-O
as SCONJ B-O
pregnancy NOUN B-O
progressed VERB B-O
to ADP B-O
mid NOUN B-O
- NOUN B-O
gestation NOUN B-O
; PUNCT B-O
it PRON B-O
increased VERB B-O
significantly ADV B-O
on ADP B-O
the DET B-O
day NOUN B-O
of ADP B-O
implantation NOUN B-O
( PUNCT B-O
E5.5 NUM B-O
) PUNCT B-O
( PUNCT B-O
15.8 NUM B-O
% NOUN B-O
) PUNCT B-O
as SCONJ B-O
compared VERB B-O
with ADP B-O
the DET B-O
nonpregnant ADJ B-O
state NOUN B-O
( PUNCT B-O
9.2 NUM B-O
% NOUN B-O
) PUNCT B-O
, PUNCT B-O
peaking VERB B-O
on ADP B-O
E9.5 NUM B-O
( PUNCT B-O
24.1 NUM B-O
% NOUN B-O
) PUNCT B-O
, PUNCT B-O
followed VERB B-O
by ADP B-O
a DET B-O
gradual ADJ B-O
decrease NOUN B-O
on ADP B-O
E13.5 NUM B-O
( PUNCT B-O
16.7 NUM B-O
% NOUN B-O
) PUNCT B-O
and CCONJ B-O
peripartum NOUN B-O
( PUNCT B-O
E17.5 NUM B-O
) PUNCT B-O
( PUNCT B-O
13.1 NUM B-O
% NOUN B-O
) PUNCT B-O
( PUNCT B-O
Fig NOUN B-O
1D NUM B-O
and CCONJ B-O
1F NUM B-O
) PUNCT B-O
. PUNCT B-O

As SCONJ B-O
the DET B-O
observed VERB B-O
increase NOUN B-O
in ADP B-O
GFP+ PROPN B-AC
cells NOUN B-O
in ADP B-O
the DET B-O
decidua NOUN B-O
during ADP B-O
pregnancy NOUN B-O
could AUX B-O
be AUX B-O
due ADJ B-O
to ADP B-O
local ADJ B-O
proliferation NOUN B-O
of ADP B-O
BMDCs PROPN B-AC
and CCONJ B-O
not PART B-O
only ADV B-O
to ADP B-O
increased VERB B-O
recruitment NOUN B-O
, PUNCT B-O
we PRON B-O
assessed VERB B-O
cell NOUN B-O
proliferation NOUN B-O
using VERB B-O
proliferating VERB B-LF
cell NOUN I-LF
nuclear ADJ I-LF
antigen NOUN I-LF
( PUNCT B-O
PCNA PROPN B-AC
) PUNCT B-O
staining NOUN B-O
. PUNCT B-O

To PART B-O
characterize VERB B-O
its PRON B-O
carbohydrate NOUN B-O
utilization NOUN B-O
capabilities NOUN B-O
, PUNCT B-O
we PRON B-O
defined VERB B-O
its PRON B-O
growth NOUN B-O
in ADP B-O
minimal ADJ B-LF
medium NOUN I-LF
( PUNCT B-O
MM PROPN B-AC
) PUNCT B-O
supplemented VERB B-O
with ADP B-O
one NUM B-O
of ADP B-O
46 NUM B-O
different ADJ B-O
carbohydrates NOUN B-O
[ PUNCT B-O
25 NUM B-O
] PUNCT B-O
. PUNCT B-O

Col-0 PROPN B-AC
, PUNCT B-O
Columbia-0 PROPN B-LF
; PUNCT B-O
CTL1 PROPN B-AC
, PUNCT B-O
choline NOUN B-LF
transporter NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
1 NUM I-LF
; PUNCT B-O
GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
FM4 PROPN B-AC
, PUNCT B-O
N-(3 NOUN B-LF
- PUNCT I-LF
Triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium NOUN I-LF
dibromide NOUN I-LF
; PUNCT B-O
-64NRAMP1 PROPN B-AC
, PUNCT B-O
natural ADJ B-LF
resistance NOUN I-LF
- PUNCT I-LF
associated VERB I-LF
macrophage NOUN I-LF
protein NOUN I-LF
1 NUM I-LF
; PUNCT B-O
PDCB PROPN B-AC
, PUNCT B-O
plasmodesmata NOUN B-LF
callose NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT B-O
sic1 PROPN B-AC
, PUNCT B-O
significant ADJ B-LF
ionome NOUN I-LF
changes NOUN I-LF
1 NUM I-LF
. PUNCT B-O

Line NOUN B-O
156 NUM B-O
: PUNCT B-O
‘ PUNCT B-O
Clustering VERB B-O
bootstrapping NOUN B-O
was AUX B-O
performed VERB B-O
to PART B-O
evaluate VERB B-O
the DET B-O
significance NOUN B-O
of ADP B-O
patient NOUN B-O
- NOUN B-O
specific ADJ B-O
clusters NOUN B-O
using VERB B-O
the DET B-O
pvclust NOUN B-O
R NOUN B-O
package NOUN B-O
( PUNCT B-O
1000 NUM B-O
repetitions NOUN B-O
) PUNCT B-O
and CCONJ B-O
significance NOUN B-O
were AUX B-O
estimated VERB B-O
by ADP B-O
Approximately ADV B-LF
Unbiased ADJ I-LF
( PUNCT B-O
AU PROPN B-AC
) PUNCT B-O
p NOUN B-O
- NOUN B-O
values NOUN B-O
: PUNCT B-O
Clusters NOUN B-O
were AUX B-O
considered VERB B-O
significant ADJ B-O
for ADP B-O
AU PROPN B-AC
values NOUN B-O
≥95 NUM B-O
, PUNCT B-O
which PRON B-O
indicates VERB B-O
a DET B-O
significance NOUN B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
≤0.05 NUM B-O
[ PUNCT B-O
30 NUM B-O
] PUNCT B-O
. PUNCT B-O

’ PUNCT B-O
B X B-O
, PUNCT B-O
Anti ADJ B-O
- ADJ B-O
FXIII PROPN B-AC
autoantibody NOUN B-O
levels NOUN B-O
measured VERB B-O
using VERB B-O
ICT PROPN B-AC
( PUNCT B-O
arbitrary ADJ B-LF
unit NOUN I-LF
; PUNCT B-O
AU PROPN B-AC
) PUNCT B-O
as SCONJ B-O
described VERB B-O
in ADP B-O
“ PUNCT B-O
Materials PROPN B-O
and CCONJ B-O
Methods PROPN B-O
” PUNCT B-O
in ADP B-O
reference NOUN B-O
allele NOUN B-O
( PUNCT B-O
T NOUN B-O
/ SYM B-O
T NOUN B-O
) PUNCT B-O
, PUNCT B-O
heterozygous ADJ B-O
allele NOUN B-O
( PUNCT B-O
T NOUN B-O
/ SYM B-O
C NOUN B-O
) PUNCT B-O
and CCONJ B-O
homozygous ADJ B-O
allele NOUN B-O
( PUNCT B-O
C NOUN B-O
/ SYM B-O
C NOUN B-O
) PUNCT B-O
at ADP B-O
chromosome NOUN B-O
6 NUM B-O
; PUNCT B-O
32363816 NUM B-O
in ADP B-O
BTNL2 NOUN B-O
( PUNCT B-O
rs2076530 NOUN B-O
) PUNCT B-O
. PUNCT B-O

Moreover ADV B-O
, PUNCT B-O
Tau PROPN B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
also ADV B-O
known VERB B-O
as ADP B-O
microtubule NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
tau NOUN I-LF
( PUNCT B-O
Mapt PROPN B-AC
) PUNCT B-O
, PUNCT B-O
is AUX B-O
abundant ADJ B-O
in ADP B-O
neurons NOUN B-O
and CCONJ B-O
plays VERB B-O
a DET B-O
critical ADJ B-O
role NOUN B-O
in ADP B-O
neurodegenerative ADJ B-O
diseases NOUN B-O
. PUNCT B-O

HDN PROPN B-AC
, PUNCT B-O
human NOUN B-LF
- PUNCT I-LF
baited VERB I-LF
double ADJ I-LF
net NOUN I-LF
trap NOUN B-O
; PUNCT B-O
HLC PROPN B-AC
, PUNCT B-O
human NOUN B-O
landing NOUN B-O
catch NOUN B-O
method NOUN B-O
. PUNCT B-O

The DET B-O
therapeutic ADJ B-O
strategies NOUN B-O
for ADP B-O
RA PROPN B-AC
have AUX B-O
developed VERB B-O
remarkably ADV B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
treat VERB B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
target NOUN I-LF
( PUNCT B-O
T2 PROPN B-AC
) PUNCT B-O
strategy NOUN B-O
described VERB B-O
in ADP B-O
the DET B-O
European PROPN B-LF
League PROPN I-LF
Against ADP I-LF
Rheumatism PROPN I-LF
( PUNCT B-O
TEULAR PROPN B-AC
) PUNCT B-O
recommendations NOUN B-O
is AUX B-O
to PART B-O
aim VERB B-O
for ADP B-O
remission NOUN B-O
or CCONJ B-O
low ADJ B-LF
disease NOUN I-LF
activity NOUN I-LF
( PUNCT B-O
LDA PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Fluid NOUN B-LF
- PUNCT I-LF
attenuated VERB I-LF
inversion NOUN I-LF
recovery NOUN I-LF
( PUNCT B-O
FLAIR PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
principle ADJ B-O
imaging NOUN B-O
sequence NOUN B-O
for ADP B-O
assessment NOUN B-O
of ADP B-O
growth NOUN B-O
of ADP B-O
low ADJ B-O
- PUNCT B-O
grade NOUN B-O
gliomas NOUN B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
the DET B-O
present ADJ B-O
study NOUN B-O
, PUNCT B-O
by ADP B-O
generating VERB B-O
new ADJ B-O
recombinant ADJ B-O
chromosomes NOUN B-LF
, PUNCT B-O
we PRON B-O
have AUX B-O
been AUX B-O
able ADJ B-O
to PART B-O
locate VERB B-O
the DET B-O
genetic ADJ B-O
element NOUN B-O
responsible ADJ B-O
for ADP B-O
Psmb9 NOUN B-O
activity NOUN B-O
within ADP B-O
6.7 NUM B-O
Mb NOUN B-O
on ADP B-O
Chr PROPN B-AC
17 NUM B-O
. PUNCT B-O

We PRON B-O
found VERB B-O
that SCONJ B-O
each DET B-O
point NOUN B-O
increase NOUN B-O
in ADP B-O
QFPC PROPN B-AC
, PUNCT B-O
including VERB B-O
increasing VERB B-O
quality NOUN B-O
of ADP B-O
counselling NOUN B-O
, PUNCT B-O
is AUX B-O
associated VERB B-O
with ADP B-O
higher ADJ B-O
odds NOUN B-O
of ADP B-O
clients NOUN B-O
selecting VERB B-O
an DET B-O
intrauterine ADJ B-LF
device NOUN I-LF
( PUNCT B-O
IUD PROPN B-AC
) PUNCT B-O
( PUNCT B-O
aRR:1.03 PROPN B-AC
; PUNCT B-O
95 NUM B-O
% NOUN B-O
CI:1.01–1.05 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
sterilization NOUN B-O
( PUNCT B-O
aRR:1.06 PROPN B-AC
; PUNCT B-O
95 NUM B-O
% NOUN B-O
CI:1.03–1.08 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
compared VERB B-O
to ADP B-O
no DET B-O
method NOUN B-O
selected VERB B-O
. PUNCT B-O

The DET B-O
aim NOUN B-O
of ADP B-O
the DET B-O
present ADJ B-O
study NOUN B-O
was AUX B-O
to PART B-O
investigate VERB B-O
the DET B-O
association NOUN B-O
between ADP B-O
the DET B-O
functional ADJ B-O
ITPA PROPN B-AC
variants NOUN B-O
and CCONJ B-O
hematological ADJ B-O
side NOUN B-O
effects NOUN B-O
during ADP B-O
antiviral ADJ B-O
therapy NOUN B-O
with ADP B-O
pegylated ADJ B-LF
interferon NOUN I-LF
( PUNCT B-O
PegIFN PROPN B-AC
) PUNCT B-O
and CCONJ B-O
RBV PROPN B-AC
. PUNCT B-O

Ressing PROPN B-O
, PUNCT B-O
Leiden PROPN B-O
University PROPN B-O
Medical PROPN B-O
Center PROPN B-O
, PUNCT B-O
the DET B-O
Netherlands PROPN B-O
[ PUNCT B-O
35 NUM B-O
] PUNCT B-O
) PUNCT B-O
were AUX B-O
cultured VERB B-O
in ADP B-O
Roswell PROPN B-LF
Park PROPN I-LF
Memorial PROPN I-LF
Institute PROPN I-LF
( PUNCT B-O
RPMI PROPN B-AC
) PUNCT B-O
medium NOUN B-O
( PUNCT B-O
Gibco PROPN B-O
) PUNCT B-O
supplemented VERB B-O
with ADP B-O
10 NUM B-O
% NOUN B-O
( PUNCT B-O
v NOUN B-O
/ SYM B-O
v NOUN B-O
) PUNCT B-O
FBS PROPN B-AC
, PUNCT B-O
2 NUM B-O
mM PROPN B-O
GlutaMAX PROPN B-O
, PUNCT B-O
1 NUM B-O
% NOUN B-O
( PUNCT B-O
v NOUN B-O
/ SYM B-O
v NOUN B-O
) PUNCT B-O
Pen PROPN B-O
- PUNCT B-O
Strep PROPN B-O
, PUNCT B-O
and CCONJ B-O
0.3 NUM B-O
mg NOUN B-O
/ SYM B-O
mL NOUN B-O
hygromycin NOUN B-O
B. NOUN B-O
A DET B-O
new ADJ B-O
release NOUN B-O
of ADP B-O
XPDF PROPN B-AC
( PUNCT B-O
a DET B-LF
PDF NOUN I-LF
viewer NOUN I-LF
for ADP I-LF
X PROPN I-LF
; PUNCT B-O
http://www.foolabs.com/xpdf/ X B-O
) PUNCT B-O
eases VERB B-O
this DET B-O
problem NOUN B-O
considerably ADV B-O
( PUNCT B-O
see VERB B-O
Materials PROPN B-O
and CCONJ B-O
Methods PROPN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
rodent NOUN B-O
models NOUN B-O
of ADP B-O
chronic ADJ B-O
inflammatory ADJ B-O
and CCONJ B-O
neuropathic ADJ B-O
pain NOUN B-O
, PUNCT B-O
there PRON B-O
is VERB B-O
a DET B-O
male NOUN B-O
- PUNCT B-O
specific ADJ B-O
activation NOUN B-O
of ADP B-O
microglial ADJ B-O
signaling NOUN B-O
in ADP B-O
the DET B-O
spinal ADJ B-O
cord NOUN B-O
, PUNCT B-O
which PRON B-O
includes VERB B-O
the DET B-O
up NOUN B-O
- PUNCT B-O
regulation NOUN B-O
of ADP B-O
P2X4 NOUN B-O
receptors NOUN B-O
[ PUNCT B-O
38 NUM B-O
] PUNCT B-O
, PUNCT B-O
phosphorylation NOUN B-O
of ADP B-O
p38−mitogen NOUN B-O
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT B-O
MAPK PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
39 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
subsequent ADJ B-O
synthesis NOUN B-O
and CCONJ B-O
release NOUN B-O
of ADP B-O
BDNF PROPN B-AC
[ PUNCT B-O
20 NUM B-O
] PUNCT B-O
. PUNCT B-O

This DET B-O
newly ADV B-O
evolved VERB B-O
cell NOUN B-O
type NOUN B-O
is AUX B-O
rigidly ADV B-O
specified VERB B-O
early ADV B-O
in ADP B-O
development NOUN B-O
through ADP B-O
the DET B-O
activity NOUN B-O
of ADP B-O
localized VERB B-O
maternal ADJ B-O
factors NOUN B-O
and CCONJ B-O
deploys VERB B-O
a DET B-O
well ADV B-O
- PUNCT B-O
characterized VERB B-O
gene NOUN B-LF
regulatory ADJ I-LF
network NOUN I-LF
( PUNCT B-O
GRN PROPN B-AC
) PUNCT B-O
that PRON B-O
controls VERB B-O
the DET B-O
morphogenetic ADJ B-O
behaviors NOUN B-O
and CCONJ B-O
biomineral NOUN B-O
- PUNCT B-O
forming VERB B-O
properties NOUN B-O
of ADP B-O
PMCs PROPN B-AC
[ X B-O
1–3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Calreticulin NOUN B-LF
( PUNCT B-O
CRT PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
multifunctional ADJ B-O
stress NOUN B-O
- PUNCT B-O
response NOUN B-O
chaperone NOUN B-O
residing VERB B-O
mainly ADV B-O
in ADP B-O
the DET B-O
lumen NOUN B-O
of ADP B-O
the DET B-O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT B-O
ER PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
cell NOUN B-O
with ADP B-O
the DET B-O
ability NOUN B-O
to PART B-O
control VERB B-O
proper ADJ B-O
protein NOUN B-O
folding NOUN B-O
and CCONJ B-O
regulate VERB B-O
cellular ADJ B-O
adhesion NOUN B-O
[ PUNCT B-O
1–6 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
have AUX B-O
previously ADV B-O
reported VERB B-O
that SCONJ B-O
the DET B-O
structure NOUN B-O
and CCONJ B-O
composition NOUN B-O
of ADP B-O
HF PROPN B-AC
- PUNCT B-O
released VERB B-O
secondary ADJ B-LF
cell NOUN I-LF
wall NOUN I-LF
polysaccharides NOUN I-LF
( PUNCT B-O
HF PROPN B-AC
) PUNCT B-O
from ADP B-O
Ba PROPN B-O
vegetative ADJ B-O
cells NOUN B-O
are AUX B-O
not PART B-O
dependent ADJ B-O
on ADP B-O
plasmid NOUN B-O
content NOUN B-O
[ X B-O
11 NUM B-O
] PUNCT B-O
, PUNCT B-O
are AUX B-O
specific ADJ B-O
for ADP B-O
Ba PROPN B-O
and CCONJ B-O
antigenic ADJ B-O
[ X B-O
12–14 NUM B-O
] PUNCT B-O
. PUNCT B-O

PDCD10 PROPN B-AC
complexes NOUN B-O
with ADP B-O
CCM1 PROPN B-O
( PUNCT B-O
Krev PROPN B-LF
/ SYM I-LF
Rap1 PROPN I-LF
Interacting PROPN I-LF
Trapped PROPN I-LF
1 NUM I-LF
[ PUNCT B-O
KRIT1 PROPN B-AC
] PUNCT B-O
) PUNCT B-O
and CCONJ B-O
CCM2 PROPN B-O
( PUNCT B-O
osmosensing VERB B-LF
scaffold NOUN I-LF
for ADP I-LF
mitogen NOUN I-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
kinase NOUN I-LF
kinase-3 NOUN I-LF
[ PUNCT B-O
OSM PROPN B-AC
] PUNCT B-O
) PUNCT B-O
to PART B-O
control VERB B-O
the DET B-O
onset NOUN B-O
of ADP B-O
a DET B-O
detrimental ADJ B-O
disease NOUN B-O
named VERB B-O
CCM PROPN B-AC
. PUNCT B-O

CCM PROPN B-AC
is AUX B-O
characterized VERB B-O
by ADP B-O
vascular ADJ B-O
lesions NOUN B-O
in ADP B-O
the DET B-O
central ADJ B-O
nervous ADJ B-O
system NOUN B-O
[ PUNCT B-O
14 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
Simes PROPN B-O
multiple ADJ B-O
- NOUN B-O
test NOUN B-O
procedure NOUN B-O
was AUX B-O
used VERB B-O
for ADP B-O
controlling VERB B-O
the DET B-O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
FDR PROPN B-AC
) PUNCT B-O
. PUNCT B-O

SNP PROPN B-AC
rs848 NUM B-O
in ADP B-O
the DET B-O
IL13 NUM B-O
gene NOUN B-O
region NOUN B-O
( PUNCT B-O
IL5 NOUN B-O
/ SYM B-O
RAD50 NOUN B-O
/ SYM B-O
IL13 NUM B-O
/ SYM B-O
IL4 NUM B-O
) PUNCT B-O
was AUX B-O
associated VERB B-O
with ADP B-O
STS PROPN B-AC
( PUNCT B-O
TG NOUN B-O
/ SYM B-O
GG NOUN B-O
vs ADP B-O
TT PROPN B-O
genotype NOUN B-O
: PUNCT B-O
uncorrected ADJ B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
= SYM B-O
0.00006 NUM B-O
, PUNCT B-O
FDR PROPN B-AC
- NOUN B-O
corrected VERB B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
= SYM B-O
0.04 NUM B-O
) PUNCT B-O
, PUNCT B-O
whereas SCONJ B-O
rs20541 NOUN B-O
in ADP B-O
the DET B-O
same ADJ B-O
gene NOUN B-O
region NOUN B-O
, PUNCT B-O
in ADP B-O
linkage NOUN B-O
disequilibrium NOUN B-O
with ADP B-O
rs848 NUM B-O
( PUNCT B-O
r2 NOUN B-O
= SYM B-O
0.94 NUM B-O
) PUNCT B-O
in ADP B-O
our PRON B-O
sample NOUN B-O
, PUNCT B-O
did AUX B-O
not PART B-O
reach VERB B-O
the DET B-O
statistical ADJ B-O
significance NOUN B-O
after ADP B-O
adjusting VERB B-O
for ADP B-O
multiple ADJ B-O
testing NOUN B-O
( PUNCT B-O
TC NOUN B-O
/ SYM B-O
CC NOUN B-O
vs ADP B-O
TT PROPN B-O
: PUNCT B-O
uncorrected ADJ B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
= SYM B-O
0.0003 NUM B-O
, PUNCT B-O
FDR PROPN B-AC
- NOUN B-O
corrected VERB B-O
p NOUN B-O
- NOUN B-O
value NOUN B-O
= SYM B-O
0.09 NUM B-O
) PUNCT B-O
. PUNCT B-O

Eukaryotic ADJ B-O
genomes NOUN B-O
contain VERB B-O
large ADJ B-O
quantities NOUN B-O
of ADP B-O
transposable ADJ B-LF
elements NOUN I-LF
( PUNCT B-O
TEs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
short ADJ B-O
self NOUN B-O
- PUNCT B-O
replicating VERB B-O
DNA NOUN B-O
sequences NOUN B-O
that PRON B-O
can AUX B-O
move VERB B-O
within ADP B-O
the DET B-O
genome NOUN B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
criteria NOUN B-O
aPL PROPN B-AC
( PUNCT B-O
aCL PROPN B-AC
and CCONJ B-O
aβ2-GPI PROPN B-AC
IgG NOUN B-O
and CCONJ B-O
IgM NOUN B-O
) PUNCT B-O
were AUX B-O
determined VERB B-O
with SCONJ B-O
four NUM B-O
well ADV B-O
- PUNCT B-O
established VERB B-O
immunoassay NOUN B-O
systems NOUN B-O
in ADP B-O
all PRON B-O
included VERB B-O
sera NOUN B-O
: PUNCT B-O
ALE PROPN B-AC
, PUNCT B-O
ACU PROPN B-AC
, PUNCT B-O
UniCAP PROPN B-LF
250 NUM I-LF
( PUNCT B-O
UNI PROPN B-AC
) PUNCT B-O
from ADP B-O
Thermo PROPN B-O
Fisher PROPN B-O
Scientific PROPN B-O
( PUNCT B-O
Freiburg PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
AESKULISA PROPN B-LF
( PUNCT B-O
AES PROPN B-AC
) PUNCT B-O
from ADP B-O
Aesku.diagnostics PROPN B-O
( PUNCT B-O
Wendelsheim PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
. PUNCT B-O

First ADV B-O
, PUNCT B-O
during ADP B-O
data NOUN B-O
preprocessing NOUN B-O
, PUNCT B-O
we PRON B-O
removed VERB B-O
oculomotor NOUN B-O
artefacts NOUN B-O
via ADP B-O
independent ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT B-O
ICA PROPN B-AC
) PUNCT B-O
( PUNCT B-O
see VERB B-O
S1 PROPN B-O
Text NOUN B-O
) PUNCT B-O
; PUNCT B-O
second X B-O
, PUNCT B-O
we PRON B-O
have AUX B-O
only ADV B-O
reported VERB B-O
data NOUN B-O
in ADP B-O
this DET B-O
paper NOUN B-O
from ADP B-O
two NUM B-O
channels NOUN B-O
near ADP B-O
the DET B-O
vertex NOUN B-O
— PUNCT B-O
C3 NOUN B-O
and CCONJ B-O
C4 NOUN B-O
, PUNCT B-O
which PRON B-O
show VERB B-O
the DET B-O
least ADJ B-O
contamination NOUN B-O
by ADP B-O
muscle NOUN B-O
and CCONJ B-O
motion NOUN B-O
artefacts NOUN B-O
. PUNCT B-O

( PUNCT B-O
See VERB B-O
S5 PROPN B-O
and CCONJ B-O
S6 PROPN B-O
Figs NOUN B-O
for ADP B-O
comparable ADJ B-O
plots NOUN B-O
of ADP B-O
anterior ADJ B-O
and CCONJ B-O
posterior ADJ B-O
midline NOUN B-O
groups NOUN B-O
. PUNCT B-O

) PUNCT B-O
Third X B-O
, PUNCT B-O
the DET B-O
cross ADJ B-O
- NOUN B-O
correlation NOUN B-O
analysis NOUN B-O
across ADP B-O
different ADJ B-O
frequencies NOUN B-O
( PUNCT B-O
Fig NOUN B-O
2A NUM B-O
) PUNCT B-O
indicated VERB B-O
that SCONJ B-O
relationships NOUN B-O
were AUX B-O
specific ADJ B-O
to ADP B-O
the DET B-O
theta NOUN B-O
band NOUN B-O
. PUNCT B-O

Prostate ADJ B-LF
- PUNCT I-LF
Specific ADJ I-LF
Antigen NOUN I-LF
( PUNCT I-LF
PSA PROPN I-LF
In ADP B-O
principle NOUN B-O
, PUNCT B-O
it PRON B-O
can AUX B-O
occur VERB B-O
via ADP B-O
any DET B-O
1 NUM B-O
of ADP B-O
3 NUM B-O
mechanisms NOUN B-O
of ADP B-O
homologous ADJ B-LF
recombination NOUN I-LF
( PUNCT B-O
HR PROPN B-AC
): PUNCT B-O
canonical ADJ B-O
DSB PROPN B-LF
repair NOUN I-LF
DSB PROPN B-AC
( PUNCT B-O
DSBR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
synthesis NOUN B-LF
- PUNCT I-LF
dependent ADJ I-LF
strand NOUN I-LF
annealing NOUN I-LF
( PUNCT B-O
SDSA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
break NOUN B-LF
- PUNCT I-LF
induced VERB I-LF
replication NOUN I-LF
( PUNCT B-O
BIR PROPN B-AC
) PUNCT B-O
( PUNCT B-O
reviewed VERB B-O
in ADP B-O
[ X B-O
21,22 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Coverage NOUN B-O
estimates NOUN B-O
are AUX B-O
generally ADV B-O
obtained VERB B-O
from ADP B-O
routine ADJ B-O
population NOUN B-O
- PUNCT B-O
based VERB B-O
household NOUN B-O
surveys NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
the DET B-O
Demographic PROPN B-O
and CCONJ B-O
Health PROPN B-O
Surveys PROPN B-O
( PUNCT B-O
DHS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
Multiple PROPN B-LF
Indicator PROPN I-LF
Cluster PROPN I-LF
Surveys PROPN I-LF
( PUNCT B-O
MICS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
primarily ADV B-O
through ADP B-O
self NOUN B-O
- PUNCT B-O
reporting NOUN B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
named VERB B-O
these PRON B-O
long ADJ B-O
expressed VERB B-LF
noncoding NOUN I-LF
regions NOUN I-LF
( PUNCT B-O
ENORs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
clinical ADJ B-O
implication NOUN B-O
of ADP B-O
AF PROPN B-AC
is AUX B-O
that SCONJ B-O
it PRON B-O
is AUX B-O
associated VERB B-O
with ADP B-O
an DET B-O
increased VERB B-O
risk NOUN B-O
of ADP B-O
stroke NOUN B-O
, PUNCT B-O
heart NOUN B-LF
failure NOUN I-LF
( PUNCT B-O
HF PROPN B-AC
) PUNCT B-O
, PUNCT B-O
myocardial ADJ B-LF
infarction NOUN I-LF
( PUNCT B-O
MI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
death NOUN B-O
[ X B-O
2,4 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
primary ADJ B-O
endpoint NOUN B-O
was AUX B-O
clinical ADJ B-O
benefit NOUN B-O
( PUNCT B-O
defined VERB B-O
as ADP B-O
stable ADJ B-LF
disease NOUN I-LF
[ PUNCT B-O
SD PROPN B-AC
] PUNCT B-O
for ADP B-O
≥6 NUM B-O
mo NOUN B-O
, PUNCT B-O
partial ADJ B-LF
response NOUN I-LF
[ PUNCT B-O
PR PROPN B-AC
] PUNCT B-O
, PUNCT B-O
or CCONJ B-O
complete ADJ B-LF
response NOUN I-LF
[ PUNCT B-O
CR PROPN B-AC
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

True ADJ B-LF
skill NOUN I-LF
statistic NOUN I-LF
( PUNCT B-O
TSS PROPN B-AC
) PUNCT B-O
was AUX B-O
used VERB B-O
as ADP B-O
a DET B-O
measure NOUN B-O
of ADP B-O
the DET B-O
model NOUN B-O
quality NOUN B-O
, PUNCT B-O
since SCONJ B-O
it PRON B-O
was AUX B-O
a DET B-O
default ADJ B-O
measure NOUN B-O
in ADP B-O
BIOMOD PROPN B-O
2.1.37 NUM B-O
[ PUNCT B-O
52 NUM B-O
] PUNCT B-O
. PUNCT B-O

A DET B-O
971 NUM B-O
- PUNCT B-O
bp PROPN B-AC
probe NOUN B-O
revealed VERB B-O
DNA NOUN B-O
rearrangements NOUN B-O
, PUNCT B-O
refining VERB B-O
the DET B-O
breakpoint NOUN B-O
to ADP B-O
a DET B-O
4.7 NUM B-O
- PUNCT B-O
kilobase NOUN B-LF
( PUNCT B-O
kb PROPN B-AC
) PUNCT B-O
interval NOUN B-O
on ADP B-O
the DET B-O
Celera PROPN B-O
scaffold NOUN B-O
sequence NOUN B-O
or CCONJ B-O
a DET B-O
4.0 NUM B-O
- PUNCT B-O
kb PROPN B-AC
interval NOUN B-O
corresponding VERB B-O
to ADP B-O
nucleotides NOUN B-O
57269–61233 NUM B-O
of ADP B-O
BAC PROPN B-AC
AC117479 NUM B-O
( PUNCT B-O
Figure NOUN B-O
1B NUM B-O
and CCONJ B-O
1D NOUN B-O
) PUNCT B-O
. PUNCT B-O

Surprisingly ADV B-O
, PUNCT B-O
the DET B-O
translocation NOUN B-O
breakpoint NOUN B-O
localized VERB B-O
within ADP B-O
the DET B-O
ortholog NOUN B-O
of ADP B-O
the DET B-O
Drosophila PROPN B-O
roundabout NOUN B-O
( PUNCT B-O
robo NOUN B-O
) PUNCT B-O
gene NOUN B-O
, PUNCT B-O
ROBO1 NOUN B-O
, PUNCT B-O
alternatively ADV B-O
spliced VERB B-O
and CCONJ B-O
also ADV B-O
named VERB B-O
DUTT1 PROPN B-O
( PUNCT B-O
Deleted VERB B-O
in ADP B-O
U PROPN B-O
Twenty PROPN B-O
Twenty PROPN B-O
) PUNCT B-O
, PUNCT B-O
disrupts VERB B-O
ROBO1 NOUN B-O
between ADP B-O
exons NOUN B-O
1 NUM B-O
and CCONJ B-O
2 NUM B-O
. PUNCT B-O

Known VERB B-O
risk NOUN B-O
factors NOUN B-O
for ADP B-O
mild ADJ B-O
CI PROPN B-AC
include VERB B-O
increased VERB B-O
age NOUN B-O
and CCONJ B-O
genetic ADJ B-O
susceptibility NOUN B-O
[ X B-O
1 NUM B-O
, PUNCT B-O
17 NUM B-O
] X B-O
while SCONJ B-O
cardiovascular ADJ B-O
disease NOUN B-O
( PUNCT B-O
high ADJ B-O
blood NOUN B-O
pressure NOUN B-O
and CCONJ B-O
stroke NOUN B-O
) PUNCT B-O
, PUNCT B-O
diabetes NOUN B-O
, PUNCT B-O
depression NOUN B-O
/ SYM B-O
anxiety NOUN B-O
, PUNCT B-O
tobacco NOUN B-O
smoking NOUN B-O
and CCONJ B-O
social ADJ B-O
factors NOUN B-O
( PUNCT B-O
e.g. X B-O
, PUNCT B-O
lack NOUN B-O
of ADP B-O
relationships NOUN B-O
with ADP B-O
others NOUN B-O
and CCONJ B-O
a DET B-O
community NOUN B-O
, PUNCT B-O
lack NOUN B-O
of ADP B-O
physical ADJ B-O
activity NOUN B-O
, PUNCT B-O
and CCONJ B-O
low ADJ B-O
socio ADJ B-LF
- ADJ I-LF
economic ADJ I-LF
status NOUN I-LF
( PUNCT B-O
SES PROPN B-AC
) PUNCT B-O
) PUNCT B-O
[ X B-O
1 NUM B-O
, PUNCT B-O
17 NUM B-O
, PUNCT B-O
18 NUM B-O
] X B-O
are AUX B-O
reported VERB B-O
as ADP B-O
possible ADJ B-O
risk NOUN B-O
factors NOUN B-O
. PUNCT B-O

DN PROPN B-AC
, PUNCT B-O
dominant NOUN B-LF
- PUNCT I-LF
negative ADJ I-LF
; PUNCT B-O
EC PROPN B-AC
, PUNCT B-O
endothelial ADJ B-LF
cell NOUN I-LF
; PUNCT B-O
GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
hpf PROPN B-AC
, PUNCT B-O
hours NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT B-O
HS PROPN B-AC
, PUNCT B-O
heat NOUN B-LF
shock NOUN I-LF
; PUNCT B-O
HSPC PROPN B-AC
, PUNCT B-O
hematopoietic ADJ B-LF
stem NOUN I-LF
and CCONJ I-LF
progenitor NOUN I-LF
cell NOUN I-LF
; PUNCT B-O
NICD PROPN B-AC
, PUNCT B-O
Notch PROPN B-LF
intracellular ADJ I-LF
domain NOUN I-LF
; PUNCT B-O
n.s NOUN B-O
. PUNCT B-O

, PUNCT B-O
nonsignificant ADJ B-O
; PUNCT B-O
qRT PROPN B-AC
, PUNCT B-O
quantitative ADJ B-LF
reverse ADJ I-LF
- PUNCT I-LF
transcription ADJ I-LF
PCR NOUN I-LF
; PUNCT B-O
WB PROPN B-O
, PUNCT B-O
western ADJ B-O
blot NOUN B-O
; PUNCT B-O
-PCRWISH PROPN B-AC
, PUNCT B-O
whole ADJ B-LF
- PUNCT I-LF
mount NOUN I-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
When SCONJ B-O
we PRON B-O
assessed VERB B-O
the DET B-O
presence NOUN B-O
of ADP B-O
inflammation NOUN B-O
in ADP B-O
the DET B-O
CNS PROPN B-AC
of ADP B-O
Nlrx1−/− PROPN B-O
2D2 PROPN B-O
spEAE PROPN B-AC
mice NOUN B-O
, PUNCT B-O
we PRON B-O
found VERB B-O
that SCONJ B-O
the DET B-O
lack NOUN B-O
of ADP B-O
NLRX1 PROPN B-AC
did AUX B-O
not PART B-O
affect VERB B-O
the DET B-O
expression NOUN B-O
of ADP B-O
glial ADJ B-LF
fibrillary NOUN I-LF
acidic ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
GFAP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
ionized VERB B-LF
calcium NOUN I-LF
binding VERB I-LF
adaptor NOUN I-LF
molecule NOUN I-LF
1(Iba1 PROPN I-LF
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
myelin NOUN B-LF
basic ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
MBP PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
spinal ADJ B-O
cords NOUN B-O
of ADP B-O
healthy ADJ B-O
Nlrx1−/− PROPN B-O
2D2 PROPN B-O
mice NOUN B-O
( PUNCT B-O
S1A PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

Our PRON B-O
method NOUN B-O
was AUX B-O
highly ADV B-O
predictive ADJ B-O
of ADP B-O
transcription NOUN B-LF
start NOUN I-LF
sites NOUN I-LF
( PUNCT B-O
TSSs PROPN B-AC
) PUNCT B-O
in ADP B-O
S. PROPN B-O
cerevisiae NOUN B-O
[ X B-O
50]—the X B-O
NFR PROPN B-O
boundary NOUN B-O
closest ADJ B-O
to PART B-O
the DET B-O
5′ NUM B-O
end NOUN B-O
of ADP B-O
the DET B-O
gene NOUN B-O
was AUX B-O
able ADJ B-O
to PART B-O
predict VERB B-O
84 NUM B-O
% NOUN B-O
of ADP B-O
TSSs PROPN B-AC
within ADP B-O
50 NUM B-O
bp NOUN B-O
. PUNCT B-O

Several ADJ B-O
lines NOUN B-O
of ADP B-O
evidence NOUN B-O
suggest VERB B-O
that SCONJ B-O
histone NOUN B-O
variants NOUN B-O
and CCONJ B-O
their PRON B-O
covalent ADJ B-O
post ADJ B-LF
- ADJ I-LF
translational ADJ I-LF
modifications NOUN I-LF
( PUNCT B-O
PTMs PROPN B-AC
) PUNCT B-O
play VERB B-O
a DET B-O
key ADJ B-O
role NOUN B-O
in ADP B-O
developmental ADJ B-O
processes NOUN B-O
such ADJ B-O
as ADP B-O
the DET B-O
initiation NOUN B-O
and CCONJ B-O
maintenance NOUN B-O
of ADP B-O
pericentric ADJ B-O
heterochromatin NOUN B-O
, PUNCT B-O
X NOUN B-O
chromosome NOUN B-O
inactivation NOUN B-O
, PUNCT B-O
and CCONJ B-O
germ NOUN B-O
cell NOUN B-O
differentiation NOUN B-O
[ PUNCT B-O
4 NUM B-O
, PUNCT B-O
11 NUM B-O
] PUNCT B-O
. PUNCT B-O

Regarding VERB B-O
the DET B-O
biological ADJ B-O
aspect NOUN B-O
, PUNCT B-O
carbon NOUN B-O
ion NOUN B-O
beams NOUN B-O
have VERB B-O
an DET B-O
estimated VERB B-O
2–3 NUM B-O
- NOUN B-O
fold ADJ B-O
higher ADJ B-O
relative ADJ B-LF
biological ADJ I-LF
effectiveness NOUN I-LF
( PUNCT B-O
RBE PROPN B-AC
) PUNCT B-O
than ADP B-O
X NOUN B-O
- NOUN B-O
rays NOUN B-O
[ PUNCT B-O
8 NUM B-O
, PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
determine VERB B-O
the DET B-O
mechanical ADJ B-O
properties NOUN B-O
of ADP B-O
the DET B-O
bone NOUN B-O
material NOUN B-O
, PUNCT B-O
the DET B-O
fourth ADJ B-O
caudal ADJ B-O
vertebrae NOUN B-O
of ADP B-O
6 NUM B-O
medaka NOUN B-O
( PUNCT B-O
3 NUM B-O
controls NOUN B-O
and CCONJ B-O
3 NUM B-O
swim NOUN B-O
- PUNCT B-O
trained VERB B-O
fish NOUN B-O
) PUNCT B-O
and CCONJ B-O
6 NUM B-O
zebrafish NOUN B-O
( PUNCT B-O
3 NUM B-O
controls NOUN B-O
and CCONJ B-O
3 NUM B-O
swim NOUN B-O
- PUNCT B-O
trained VERB B-O
fish NOUN B-O
) PUNCT B-O
were AUX B-O
dehydrated VERB B-O
with ADP B-O
increasing VERB B-O
concentrations NOUN B-O
of ADP B-O
ethanol NOUN B-O
and CCONJ B-O
embedded VERB B-O
for ADP B-O
8 NUM B-O
hours NOUN B-O
in ADP B-O
polymethylmethacrylate NOUN B-LF
( PUNCT B-O
PMMA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
was AUX B-O
polymerized VERB B-O
in ADP B-O
an DET B-O
oven NOUN B-O
at ADP B-O
60 NUM B-O
° NOUN B-O
C NOUN B-O
. PUNCT B-O

As SCONJ B-O
earlier ADV B-O
reported VERB B-O
, PUNCT B-O
Ace PROPN B-AC
protein NOUN B-O
had AUX B-O
been AUX B-O
modelled VERB B-O
using VERB B-O
a DET B-O
template NOUN B-O
structure NOUN B-O
, PUNCT B-O
zhaoermiatoxin NOUN B-O
from ADP B-O
Zhaoermia PROPN B-O
mangshanensis NOUN B-O
[ PUNCT B-O
Protein PROPN B-LF
Data PROPN I-LF
Bank PROPN I-LF
( PUNCT B-O
PDB PROPN B-AC
) NOUN B-O
entry NOUN B-O
2PH4 NOUN B-O
] PUNCT B-O
, PUNCT B-O
a DET B-O
dimeric ADJ B-O
toxin NOUN B-O
which PRON B-O
showed VERB B-O
reasonable ADJ B-O
sequence NOUN B-O
similarity NOUN B-O
( PUNCT B-O
45 NUM B-O
% NOUN B-O
) NOUN B-O
with ADP B-O
the DET B-O
target NOUN B-O
[ PUNCT B-O
7 NUM B-O
] PUNCT B-O
. PUNCT B-O

Both DET B-O
trials NOUN B-O
recruited VERB B-O
postally ADV B-O
from ADP B-O
primary ADJ B-O
care NOUN B-O
and CCONJ B-O
delivered VERB B-O
12 NUM B-O
- PUNCT B-O
week NOUN B-O
pedometer NOUN B-O
- PUNCT B-O
based VERB B-O
walking NOUN B-O
interventions NOUN B-O
incorporating VERB B-O
behaviour NOUN B-LF
change NOUN I-LF
techniques NOUN I-LF
( PUNCT B-O
BCTs PROPN B-AC
) PUNCT B-O
through ADP B-O
dedicated ADJ B-O
practice NOUN B-O
nurse NOUN B-O
PA PROPN B-AC
consultations NOUN B-O
( PUNCT B-O
3 NUM B-O
in ADP B-O
PACE PROPN B-AC
, PUNCT B-O
4 NUM B-O
in ADP B-O
-UPPACE PROPN B-AC
) PUNCT B-O
or CCONJ B-O
by ADP B-O
post NOUN B-O
( PUNCT B-O
-LiftPACE PROPN B-AC
only ADV B-O
) PUNCT B-O
. PUNCT B-O

DAS28-ESR PROPN B-AC
, PUNCT B-O
Disease PROPN B-LF
Activity PROPN I-LF
Score–28 NUM I-LF
with ADP I-LF
erythrocyte NOUN I-LF
sedimentation NOUN I-LF
rate NOUN I-LF
; PUNCT B-O
Early ADJ B-O
, PUNCT B-O
early ADJ B-O
treatment NOUN B-O
; PUNCT B-O
HAQ PROPN B-AC
, PUNCT B-O
Health PROPN B-LF
Assessment PROPN I-LF
Questionnaire NOUN I-LF
; PUNCT B-O
NSAID PROPN B-O
, PUNCT B-O
nonsteroidal ADJ B-O
anti ADJ B-O
- PUNCT B-O
inflammatory ADJ B-O
drug NOUN B-O
; PUNCT B-O
MTX PROPN B-O
, PUNCT B-O
methotrexate NOUN B-O
; PUNCT B-O
noMTX PROPN B-O
, PUNCT B-O
no DET B-O
methotrexate NOUN B-O
; PUNCT B-O
RA PROPN B-AC
, PUNCT B-O
rheumatoid ADJ B-LF
arthritis NOUN I-LF
; PUNCT B-O
SDFR PROPN B-AC
, PUNCT B-O
sustained VERB B-LF
DMARD NOUN I-LF
- PUNCT I-LF
DMARD PROPN B-AC
free ADJ I-LF
remission NOUN I-LF
; PUNCT B-O
T2 PROPN B-O
T PROPN B-O
, PUNCT B-O
treat VERB B-O
- PUNCT B-O
to ADP B-O
- PUNCT B-O
target NOUN B-O
. PUNCT B-O

Behavioral ADJ B-O
factors NOUN B-O
defined VERB B-O
by ADP B-O
the DET B-O
Kenya PROPN B-O
PrEP PROPN B-AC
guidelines NOUN B-O
to PART B-O
indicate VERB B-O
a DET B-O
substantial ADJ B-O
ongoing ADJ B-O
risk NOUN B-O
of ADP B-O
acquiring VERB B-O
HIV PROPN B-O
include VERB B-O
the DET B-O
following VERB B-O
: PUNCT B-O
( PUNCT B-O
a DET B-O
) PUNCT B-O
inconsistent ADJ B-O
or CCONJ B-O
no PRON B-O
condom NOUN B-O
use NOUN B-O
in ADP B-O
the DET B-O
last ADJ B-O
6 NUM B-O
months NOUN B-O
; PUNCT B-O
( PUNCT B-O
b X B-O
) PUNCT B-O
having VERB B-O
a DET B-O
high ADJ B-O
- PUNCT B-O
risk NOUN B-O
sex NOUN B-O
partner(s NOUN B-O
) PUNCT B-O
of ADP B-O
unknown ADJ B-O
HIV PROPN B-O
status NOUN B-O
; PUNCT B-O
( PUNCT B-O
c X B-O
) PUNCT B-O
engaging VERB B-O
in ADP B-O
transactional ADJ B-O
sex NOUN B-O
; PUNCT B-O
( PUNCT B-O
d X B-O
) PUNCT B-O
history NOUN B-O
of ADP B-O
ongoing ADJ B-O
intimate ADJ B-LF
partner NOUN I-LF
violence NOUN I-LF
( PUNCT B-O
IPV PROPN B-AC
) PUNCT B-O
and CCONJ B-O
gender NOUN B-LF
- PUNCT I-LF
based VERB I-LF
violence NOUN I-LF
( PUNCT B-O
GBV PROPN B-AC
) PUNCT B-O
; PUNCT B-O
( PUNCT B-O
e X B-O
) PUNCT B-O
recent ADJ B-O
bacterial ADJ B-O
STIs PROPN B-AC
, PUNCT B-O
self NOUN B-O
- PUNCT B-O
reported VERB B-O
or CCONJ B-O
etiologically ADV B-O
diagnosed VERB B-O
; PUNCT B-O
( PUNCT B-O
f X B-O
) PUNCT B-O
recurrent ADJ B-O
use NOUN B-O
of ADP B-O
postexposure ADJ B-O
prophylaxis NOUN B-O
; PUNCT B-O
( PUNCT B-O
g X B-O
) PUNCT B-O
recurrent ADJ B-O
sex NOUN B-O
under ADP B-O
the DET B-O
influence NOUN B-O
of ADP B-O
alcohol NOUN B-O
and/or CCONJ B-O
recreational ADJ B-O
drugs NOUN B-O
; PUNCT B-O
( PUNCT B-O
h X B-O
) PUNCT B-O
injection NOUN B-O
drug NOUN B-O
use NOUN B-O
with ADP B-O
shared VERB B-O
needles NOUN B-O
and/or CCONJ B-O
syringes NOUN B-O
; PUNCT B-O
and CCONJ B-O
( PUNCT B-O
i X B-O
) PUNCT B-O
having VERB B-O
an DET B-O
HIV PROPN B-O
- PUNCT B-O
positive ADJ B-O
partner NOUN B-O
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

One NUM B-O
recent ADJ B-O
study NOUN B-O
found VERB B-O
that SCONJ B-O
healthy ADJ B-O
lifestyle NOUN B-O
profiles NOUN B-O
were AUX B-O
associated VERB B-O
with ADP B-O
lower ADJ B-O
risks NOUN B-O
of ADP B-O
dementia NOUN B-O
only ADV B-O
among ADP B-O
apolipoprotein NOUN B-LF
E PROPN I-LF
( PUNCT B-O
APOE PROPN B-AC
) PUNCT B-O
ε4 NUM B-O
noncarriers NOUN B-O
, PUNCT B-O
but CCONJ B-O
not PART B-O
among ADP B-O
carriers NOUN B-O
. PUNCT B-O

HIV PROPN B-AC
/ SYM B-O
AIDS PROPN B-AC
predisposes VERB B-O
for ADP B-O
Mycobacterium NOUN B-O
tuberculosis NOUN B-LF
( PUNCT B-O
MTB NOUN B-O
) PUNCT B-O
infection NOUN B-O
and CCONJ B-O
increases VERB B-O
the DET B-O
rate NOUN B-O
of ADP B-O
recurrent ADJ B-O
TB PROPN B-AC
as ADP B-O
well ADV B-O
as ADP B-O
of ADP B-O
rapid ADJ B-O
progress NOUN B-O
to ADP B-O
active ADJ B-O
TB PROPN B-AC
among ADP B-O
individuals NOUN B-O
with ADP B-O
recently ADV B-O
acquired VERB B-O
infection NOUN B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

These DET B-O
properties NOUN B-O
of ADP B-O
the DET B-O
IVs PROPN B-AC
are AUX B-O
discussed VERB B-O
in ADP B-O
more ADJ B-O
detail NOUN B-O
in ADP B-O
the DET B-O
section NOUN B-O
, PUNCT B-O
Assumptions NOUN B-O
and CCONJ B-O
Limitations NOUN B-O
of ADP B-O
Instrumental ADJ B-LF
Variables NOUN I-LF
in ADP B-O
Text PROPN B-O
S1 NUM B-O
. PUNCT B-O

CDS PROPN B-AC
, PUNCT B-O
coding NOUN B-LF
sequence NOUN I-LF
; PUNCT B-O
TE PROPN B-AC
, PUNCT B-O
transposable ADJ B-LF
element NOUN I-LF
. PUNCT B-O

On ADP B-O
exposure NOUN B-O
to ADP B-O
stress NOUN B-O
condition NOUN B-O
these DET B-O
defence NOUN B-O
systems NOUN B-O
are AUX B-O
activated VERB B-O
both CCONJ B-O
enzymatically ADV B-O
( PUNCT B-O
ascorbate NOUN B-O
peroxidase NOUN B-O
, PUNCT B-O
catalase NOUN B-O
, PUNCT B-O
superoxide NOUN B-O
dismutase NOUN B-O
and CCONJ B-O
peroxidase NOUN B-O
) PUNCT B-O
and CCONJ B-O
non ADV B-O
- ADV B-O
enzymatically ADV B-O
( PUNCT B-O
secondary ADJ B-O
metabolites NOUN B-O
) PUNCT B-O
scavenging VERB B-O
the DET B-O
reactive ADJ B-LF
oxygen NOUN I-LF
species NOUN I-LF
( PUNCT B-O
ROS PROPN B-AC
) PUNCT B-O
formed VERB B-O
as ADP B-O
result NOUN B-O
of ADP B-O
stress NOUN B-O
condition NOUN B-O
[ PUNCT B-O
76 NUM B-O
] PUNCT B-O
. PUNCT B-O

EV PROPN B-AC
, PUNCT B-O
extracellular ADJ B-LF
vesicle NOUN I-LF
; PUNCT B-O
LPS PROPN B-AC
, PUNCT B-O
lipopolysaccharide NOUN B-LF
. PUNCT B-O

Pseudohyphal ADJ B-O
growth NOUN B-O
requires VERB B-O
the DET B-O
initiation NOUN B-O
of ADP B-O
polarised ADJ B-O
growth NOUN B-O
for ADP B-O
cellular ADJ B-O
elongation NOUN B-O
and CCONJ B-O
is AUX B-O
under ADP B-O
the DET B-O
control NOUN B-O
of ADP B-O
two NUM B-O
signaling NOUN B-O
pathways NOUN B-O
: PUNCT B-O
a DET B-O
cyclic ADJ B-LF
adenosine NOUN I-LF
monophosphate NOUN I-LF
( PUNCT B-O
kinase NOUN I-LF
cAMP)/protein PROPN B-AC
A NOUN I-LF
( PUNCT B-O
PKA PROPN B-AC
) PUNCT B-O
pathway NOUN B-O
and CCONJ B-O
a DET B-O
mitogen NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT B-O
MAPK PROPN B-AC
) PUNCT B-O
cascade NOUN B-O
. PUNCT B-O

Half NOUN B-O
of ADP B-O
the DET B-O
digest NOUN B-O
( PUNCT B-O
500 NUM B-O
µl NOUN B-O
) PUNCT B-O
was AUX B-O
loaded VERB B-O
on ADP B-O
a DET B-O
strong ADJ B-LF
anion NOUN I-LF
exchange NOUN I-LF
( PUNCT B-O
SAX PROPN B-AC
) PUNCT B-O
column NOUN B-O
( PUNCT B-O
SAX PROPN B-AC
- PUNCT B-O
Zirchrom PROPN B-O
2.1 NUM B-O
mm NOUN B-O
I.D.×150 NOUN B-O
mm NOUN B-O
length NOUN B-O
; PUNCT B-O
3 NUM B-O
µm NOUN B-O
particles NOUN B-O
, PUNCT B-O
ZirChrom PROPN B-O
Separations PROPN B-O
, PUNCT B-O
Anoka PROPN B-O
, PUNCT B-O
MN PROPN B-O
, PUNCT B-O
USA PROPN B-O
) PUNCT B-O
after ADP B-O
which PRON B-O
a DET B-O
binary ADJ B-O
solvent NOUN B-O
gradient NOUN B-O
was AUX B-O
applied VERB B-O
to ADP B-O
fractionate NOUN B-O
peptides NOUN B-O
. PUNCT B-O

The DET B-O
host NOUN B-O
- PUNCT B-O
encoded VERB B-O
glycophosphatidylinositol NOUN B-O
anchored VERB B-O
prion NOUN B-O
protein NOUN B-O
, PUNCT B-O
PrPC PROPN B-O
, PUNCT B-O
is AUX B-O
essential ADJ B-O
for ADP B-O
the DET B-O
development NOUN B-O
of ADP B-O
TSE PROPN B-AC
disease NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
a DET B-O
common ADJ B-O
feature NOUN B-O
of ADP B-O
these DET B-O
diseases NOUN B-O
is AUX B-O
the DET B-O
accumulation NOUN B-O
of ADP B-O
PrPSc PROPN B-O
in ADP B-O
the DET B-O
brain NOUN B-O
, PUNCT B-O
an DET B-O
abnormal ADJ B-O
form NOUN B-O
of ADP B-O
PrPC PROPN B-O
, PUNCT B-O
which PRON B-O
displays VERB B-O
partial ADJ B-O
resistance NOUN B-O
to ADP B-O
proteinase NOUN B-LF
K PROPN I-LF
( PUNCT B-O
PK PROPN B-AC
) PUNCT B-O
digestion NOUN B-O
. PUNCT B-O

Lung NOUN B-O
adenocarcinomas NOUN B-O
from ADP B-O
patients NOUN B-O
who PRON B-O
respond VERB B-O
to ADP B-O
the DET B-O
tyrosine NOUN B-O
kinase NOUN B-O
inhibitors NOUN B-O
gefitinib PROPN B-O
( PUNCT B-O
Iressa PROPN B-O
) PUNCT B-O
or CCONJ B-O
erlotinib PROPN B-O
( PUNCT B-O
Tarceva PROPN B-O
) PUNCT B-O
usually ADV B-O
harbor VERB B-O
somatic ADJ B-O
gain NOUN B-O
- PUNCT B-O
of ADP B-O
- PUNCT B-O
function NOUN B-O
mutations NOUN B-O
in ADP B-O
exons NOUN B-O
encoding VERB B-O
the DET B-O
kinase NOUN B-O
domain NOUN B-O
of ADP B-O
the DET B-O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
receptor NOUN I-LF
( PUNCT B-O
EGFR PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Despite SCONJ B-O
initial ADJ B-O
responses NOUN B-O
, PUNCT B-O
patients NOUN B-O
eventually ADV B-O
progress VERB B-O
by ADP B-O
unknown ADJ B-O
mechanisms NOUN B-O
of ADP B-O
“ PUNCT B-O
acquired VERB B-O
” PUNCT B-O
resistance NOUN B-O
. PUNCT B-O

A DET B-O
total NOUN B-O
of ADP B-O
1,045 NUM B-O
genes NOUN B-O
( PUNCT B-O
551 NUM B-O
up ADV B-O
- PUNCT B-O
regulated VERB B-O
and CCONJ B-O
494 NUM B-O
down ADV B-O
- PUNCT B-O
regulated VERB B-O
) PUNCT B-O
were AUX B-O
DE PROPN B-AC
in ADP B-O
the DET B-O
FPC PROPN B-AC
/ SYM B-O
CC PROPN B-AC
( PUNCT B-O
region NOUN B-O
1 NUM B-O
, PUNCT B-O
S1 NUM B-O
Table PROPN B-O
) PUNCT B-O
, PUNCT B-O
644 NUM B-O
genes NOUN B-O
( PUNCT B-O
492 NUM B-O
up ADV B-O
- PUNCT B-O
regulated VERB B-O
and CCONJ B-O
152 NUM B-O
down ADV B-O
- PUNCT B-O
regulated VERB B-O
) PUNCT B-O
in ADP B-O
the DET B-O
HP PROPN B-AC
( PUNCT B-O
region NOUN B-O
2 NUM B-O
, PUNCT B-O
S2 NUM B-O
Table PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
1,137 NUM B-O
( PUNCT B-O
526 NUM B-O
up ADV B-O
- PUNCT B-O
regulated VERB B-O
and CCONJ B-O
611 NUM B-O
downregulated ADJ B-O
) PUNCT B-O
in ADP B-O
the DET B-O
RB PROPN B-AC
( PUNCT B-O
region NOUN B-O
3 NUM B-O
, PUNCT B-O
S3 PROPN B-O
Table PROPN B-O
) PUNCT B-O
( PUNCT B-O
Fig NOUN B-O
1A NUM B-O
) PUNCT B-O
. PUNCT B-O

Gene NOUN B-O
set NOUN B-O
enrichment NOUN B-O
analysis NOUN B-O
( PUNCT B-O
using VERB B-O
DAVID PROPN B-O
, PUNCT B-O
see VERB B-O
Methods NOUN B-O
) PUNCT B-O
showed VERB B-O
significant ADJ B-O
differences NOUN B-O
between ADP B-O
the DET B-O
regions NOUN B-O
, PUNCT B-O
i.e. X B-O
, PUNCT B-O
DE PROPN B-AC
genes NOUN B-O
from ADP B-O
each PRON B-O
of ADP B-O
the DET B-O
three NUM B-O
regions NOUN B-O
were AUX B-O
present ADJ B-O
in ADP B-O
overlapping VERB B-O
but CCONJ B-O
not PART B-O
identical ADJ B-O
Kyoto PROPN B-LF
Encyclopedia PROPN I-LF
of ADP I-LF
genes NOUN I-LF
and CCONJ I-LF
genomes NOUN I-LF
( PUNCT B-O
KEGG PROPN B-AC
) PUNCT B-O
pathways NOUN B-O
( PUNCT B-O
S4 PROPN B-O
Table PROPN B-O
) PUNCT B-O
. PUNCT B-O

NSE PROPN B-AC
, PUNCT B-O
neuron NOUN B-LF
specific ADJ I-LF
enolase NOUN I-LF
. PUNCT B-O

In ADP B-O
a DET B-O
next ADJ B-O
step NOUN B-O
we PRON B-O
further ADV B-O
quantified VERB B-O
the DET B-O
voltage NOUN B-O
firing NOUN B-O
threshold NOUN B-O
( PUNCT B-O
-28 NUM B-O
– PUNCT B-O
-49 NUM B-O
mV NOUN B-O
) PUNCT B-O
, PUNCT B-O
the DET B-O
maximum ADJ B-O
firing NOUN B-O
frequency NOUN B-O
( PUNCT B-O
10–202 NUM B-O
Hz NOUN B-O
) PUNCT B-O
in ADP B-O
response NOUN B-O
to ADP B-O
a DET B-O
100 NUM B-O
pA NOUN B-O
step NOUN B-O
, PUNCT B-O
the DET B-O
amplitude NOUN B-O
of ADP B-O
both CCONJ B-O
spontaneous ADJ B-O
( PUNCT B-O
18–80 NUM B-O
mV NOUN B-O
) PUNCT B-O
and CCONJ B-O
evoked VERB B-O
action NOUN B-O
potentials NOUN B-O
( PUNCT B-O
17–76 NUM B-O
mV NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
amplitude NOUN B-O
( PUNCT B-O
0–18 NUM B-O
mV NOUN B-O
) PUNCT B-O
and CCONJ B-O
time NOUN B-O
point NOUN B-O
of ADP B-O
the DET B-O
fast ADJ B-LF
after ADP I-LF
- PUNCT I-LF
hyperpolarization NOUN I-LF
peak NOUN I-LF
( PUNCT B-O
fAHP PROPN B-AC
) PUNCT B-O
following VERB B-O
a DET B-O
spike NOUN B-O
( PUNCT B-O
0,2–3,8 NUM B-O
ms NOUN B-O
) PUNCT B-O
. PUNCT B-O

Fluorescence NOUN B-LF
correlation NOUN I-LF
spectroscopy NOUN I-LF
( PUNCT B-O
FCS PROPN B-AC
) PUNCT B-O
measurements NOUN B-O
were AUX B-O
carried VERB B-O
out ADP B-O
with ADP B-O
a DET B-O
home NOUN B-O
- PUNCT B-O
made VERB B-O
FCS PROPN B-AC
setup NOUN B-O
[ X B-O
56,57 X B-O
] X B-O
including VERB B-O
an DET B-O
Olympus PROPN B-O
IMT-2 PROPN B-O
inverted ADJ B-O
microscope NOUN B-O
with ADP B-O
a DET B-O
40x NUM B-O
, PUNCT B-O
NA NOUN B-O
1.2 NUM B-O
water NOUN B-O
immersion NOUN B-O
objective NOUN B-O
( PUNCT B-O
Carl PROPN B-O
Zeiss PROPN B-O
, PUNCT B-O
Jena PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
. PUNCT B-O

Given VERB B-O
clinicians NOUN B-O
’ PUNCT B-O
frequent ADJ B-O
concerns NOUN B-O
about ADP B-O
unfavourable ADJ B-O
outcomes NOUN B-O
, PUNCT B-O
Intensive PROPN B-LF
Care PROPN I-LF
Unit PROPN I-LF
( PUNCT B-O
ICU PROPN B-AC
) PUNCT B-O
triage NOUN B-O
decisions NOUN B-O
in ADP B-O
acutely ADV B-O
ill ADJ B-O
cancer NOUN B-O
patients NOUN B-O
can AUX B-O
be AUX B-O
difficult ADJ B-O
, PUNCT B-O
as SCONJ B-O
clinicians NOUN B-O
may AUX B-O
have VERB B-O
doubts NOUN B-O
about ADP B-O
the DET B-O
appropriateness NOUN B-O
of ADP B-O
an DET B-O
ICU PROPN B-AC
admission NOUN B-O
. PUNCT B-O

While SCONJ B-O
Categories NOUN B-O
I NUM B-O
and CCONJ B-O
II NUM B-O
are AUX B-O
integrated VERB B-O
in ADP B-O
the DET B-O
swing NOUN B-O
equation NOUN B-O
, PUNCT B-O
the DET B-O
admittance NOUN B-LF
matrix NOUN I-LF
Y PROPN B-AC
is AUX B-O
modified VERB B-O
to PART B-O
incorporate VERB B-O
Categories NOUN B-O
III NUM B-O
and CCONJ B-O
IV NUM B-O
in ADP B-O
terms NOUN B-O
of ADP B-O
the DET B-O
voltage NOUN B-O
– PUNCT B-O
current NOUN B-O
relationship NOUN B-O
. PUNCT B-O

Further ADJ B-O
cryogenic ADJ B-LF
electron NOUN I-LF
microscopy NOUN I-LF
( PUNCT B-O
cryo-EM PROPN B-AC
) PUNCT B-O
maps NOUN B-O
of ADP B-O
the DET B-O
CsgG PROPN B-O
- PUNCT B-O
CsgE PROPN B-O
complex NOUN B-O
indicate VERB B-O
that SCONJ B-O
CsgE PROPN B-O
could AUX B-O
oligomerize VERB B-O
to PART B-O
form VERB B-O
nonamers NOUN B-O
in ADP B-O
the DET B-O
periplasm NOUN B-O
, PUNCT B-O
“ PUNCT B-O
capping VERB B-O
” PUNCT B-O
the DET B-O
periplasmic ADJ B-O
side NOUN B-O
of ADP B-O
the DET B-O
CsgG PROPN B-O
channel NOUN B-O
[ PUNCT B-O
26,27 NUM B-O
] PUNCT B-O
. PUNCT B-O

To PART B-O
produce VERB B-O
LEGO PROPN B-AC
libraries NOUN B-O
, PUNCT B-O
we PRON B-O
designed VERB B-O
a DET B-O
set NOUN B-O
of ADP B-O
oligonucleotide NOUN B-O
adapters NOUN B-O
A NOUN B-O
, PUNCT B-O
B NOUN B-O
, PUNCT B-O
and CCONJ B-O
C NOUN B-O
( PUNCT B-O
Figures NOUN B-O
A NOUN B-O
, PUNCT B-O
B NOUN B-O
in ADP B-O
S1 NUM B-O
Fig NOUN B-O
) PUNCT B-O
that PRON B-O
allow VERB B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
highly ADV B-O
optimized VERB B-O
PCR NOUN B-O
- PUNCT B-O
based VERB B-O
Suppression PROPN B-LF
Subtractive PROPN I-LF
Hybridization PROPN I-LF
( PUNCT B-O
SSH PROPN B-AC
) PUNCT B-O
of ADP B-O
two NUM B-O
transcriptomes NOUN B-O
[ X B-O
7 X B-O
] X B-O
to PART B-O
selectively ADV B-O
amplify VERB B-O
cDNA NOUN B-O
sequences NOUN B-O
from ADP B-O
repressed VERB B-O
polyadenylated VERB B-O
transcripts NOUN B-O
( PUNCT B-O
see VERB B-O
for ADP B-O
schematic ADJ B-O
design NOUN B-O
Figures NOUN B-O
C NOUN B-O
, PUNCT B-O
D NOUN B-O
in ADP B-O
S1 NUM B-O
Fig NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
( PUNCT B-O
2 X B-O
) PUNCT B-O
subsequent ADJ B-O
enzymatic ADJ B-O
processing NOUN B-O
of ADP B-O
selected VERB B-O
cDNA NOUN B-O
sequences NOUN B-O
into ADP B-O
a DET B-O
library NOUN B-O
of ADP B-O
pRETRO PROPN B-O
Super PROPN B-O
shRNA NOUN B-O
vectors NOUN B-O
for ADP B-O
screening NOUN B-O
( PUNCT B-O
Figure PROPN B-O
I NUM B-O
in ADP B-O
S1 NUM B-O
Fig NOUN B-O
) PUNCT B-O
. PUNCT B-O

* PUNCT B-O
As ADP B-O
compared VERB B-O
with ADP B-O
female NOUN B-O
; PUNCT B-O
Ref NOUN B-O
: PUNCT B-O
reference NOUN B-O
category NOUN B-O
; PUNCT B-O
reduced VERB B-O
staff NOUN B-O
: PUNCT B-O
weekend NOUN B-O
and CCONJ B-O
public ADJ B-O
holydays NOUN B-O
admissions NOUN B-O
; PUNCT B-O
RRT PROPN B-AC
: PUNCT B-O
renal ADJ B-LF
replacement NOUN I-LF
therapy NOUN I-LF
; PUNCT B-O
“ PUNCT B-O
SAMU PROPN B-O
” PUNCT B-O
: PUNCT B-O
Service PROPN B-O
d’Aide PROPN B-O
Médicale PROPN B-O
Urgente PROPN B-O
: PUNCT B-O
mobile ADJ B-O
emergency NOUN B-O
team NOUN B-O
. PUNCT B-O

CTRL PROPN B-O
, PUNCT B-O
control NOUN B-O
group NOUN B-O
; PUNCT B-O
ECD PROPN B-AC
, PUNCT B-O
early ADJ B-LF
child NOUN I-LF
development NOUN I-LF
; PUNCT B-O
EI PROPN B-O
, PUNCT B-O
Educación PROPN B-O
Inicial PROPN B-O
; PUNCT B-O
ICDS PROPN B-O
, PUNCT B-O
Integrated PROPN B-O
Child PROPN B-O
Development PROPN B-O
Services PROPN B-O
; PUNCT B-O
INT PROPN B-O
, PUNCT B-O
intervention NOUN B-O
group NOUN B-O
; PUNCT B-O
RCT PROPN B-O
, PUNCT B-O
randomized VERB B-O
controlled ADJ B-O
trial NOUN B-O
; PUNCT B-O
RFS PROPN B-O
, PUNCT B-O
Responsive PROPN B-O
Feeding PROPN B-O
and CCONJ B-O
Stimulation PROPN B-O
; PUNCT B-O
VIP PROPN B-O
, PUNCT B-O
Video PROPN B-O
Interaction PROPN B-O
Project PROPN B-O
; PUNCT B-O
VIPP PROPN B-O
, PUNCT B-O
video NOUN B-O
- PUNCT B-O
feedback NOUN B-O
intervention NOUN B-O
to PART B-O
promote VERB B-O
positive ADJ B-O
parenting NOUN B-O
; PUNCT B-O
Of ADP B-O
the DET B-O
49,717 NUM B-O
individuals NOUN B-O
enrolled VERB B-O
in ADP B-O
the DET B-O
D:A:D PROPN B-AC
study NOUN B-O
, PUNCT B-O
27,215 NUM B-O
( PUNCT B-O
55 NUM B-O
% PUNCT B-O
) PUNCT B-O
had VERB B-O
the DET B-O
required VERB B-O
complete ADJ B-O
covariate NOUN B-O
data NOUN B-O
after ADP B-O
1 NUM B-O
January PROPN B-O
2004 NUM B-O
and CCONJ B-O
were AUX B-O
included VERB B-O
in ADP B-O
this DET B-O
analysis NOUN B-O
, PUNCT B-O
contributing VERB B-O
202,034 NUM B-O
person NOUN B-LF
- PUNCT I-LF
years NOUN I-LF
( PUNCT B-O
pyrs PROPN B-AC
) PUNCT B-O
of ADP B-O
follow NOUN B-O
- PUNCT B-O
up NOUN B-O
. PUNCT B-O

We PRON B-O
calculated VERB B-O
the DET B-O
sensitivity NOUN B-O
, PUNCT B-O
specificity NOUN B-O
and CCONJ B-O
accuracy NOUN B-O
of ADP B-O
our PRON B-O
algorithm NOUN B-O
to PART B-O
detect VERB B-O
VVA PROPN B-AC
after ADP B-O
finding VERB B-O
an DET B-O
optimal ADJ B-O
DCVV PROPN B-AC
cut NOUN B-O
- PUNCT B-O
off NOUN B-O
using VERB B-O
Receiver PROPN B-LF
Operating PROPN I-LF
Characteristics NOUN I-LF
( PUNCT B-O
ROC PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Youden PROPN B-O
- PUNCT B-O
Index PROPN B-O
( PUNCT B-O
J NOUN B-O
) PUNCT B-O
. PUNCT B-O

A DET B-O
ROC PROPN B-AC
curve NOUN B-O
was AUX B-O
generated VERB B-O
using VERB B-O
SPSS PROPN B-O
. PUNCT B-O

For ADP B-O
all DET B-O
statistical ADJ B-O
analyses NOUN B-O
, PUNCT B-O
the DET B-O
level NOUN B-O
of ADP B-O
significance NOUN B-O
was AUX B-O
set VERB B-O
at ADP B-O
p NOUN B-O
< ADP B-O
0.05 NUM B-O
( PUNCT B-O
two NUM B-O
- PUNCT B-O
tailed VERB B-O
) PUNCT B-O
. PUNCT B-O

Deletion NOUN B-O
of ADP B-O
kinases NOUN B-O
regulated VERB B-O
by ADP B-O
Ras PROPN B-O
such ADJ B-O
as ADP B-O
extracellular ADJ B-LF
signal NOUN I-LF
regulated VERB I-LF
kinase NOUN I-LF
( PUNCT B-O
ERK PROPN B-AC
) PUNCT B-O
, PUNCT B-O
glycogen NOUN B-O
synthase NOUN B-O
kinase NOUN B-O
( PUNCT B-O
GSK-3 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
mammalian ADJ B-LF
target NOUN I-LF
of ADP I-LF
rapamycin NOUN I-LF
( PUNCT B-O
mTOR PROPN B-AC
) PUNCT B-O
in ADP B-O
discrete ADJ B-O
populations NOUN B-O
of ADP B-O
MSNs PROPN B-AC
also ADV B-O
affects VERB B-O
motor NOUN B-O
activity NOUN B-O
and/or CCONJ B-O
responses NOUN B-O
to ADP B-O
psychostimulants NOUN B-O
[ PUNCT B-O
28–30 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
similar ADJ B-O
effects NOUN B-O
are AUX B-O
observed VERB B-O
upon SCONJ B-O
changes NOUN B-O
in ADP B-O
Ras PROPN B-O
activity NOUN B-O
[ PUNCT B-O
31,32 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
some DET B-O
organisms NOUN B-O
, PUNCT B-O
additional ADJ B-O
γ PUNCT B-LF
- PUNCT I-LF
tubulin NOUN I-LF
complex NOUN I-LF
proteins NOUN I-LF
( PUNCT B-O
GCPs PROPN B-AC
) PUNCT B-O
combine VERB B-O
with ADP B-O
the DET B-O
γ PROPN B-AC
to PART B-O
form VERB B-O
the DET B-O
larger ADJ B-O
γ PUNCT B-LF
- PUNCT I-LF
tubulin NOUN I-LF
ring NOUN I-LF
complex NOUN I-LF
( PUNCT B-O
-TuSCγ PROPN B-AC
) PUNCT B-O
; PUNCT B-O
organisms NOUN B-O
lacking VERB B-O
these DET B-O
additional ADJ B-O
-TuRCGCPs PROPN B-AC
are AUX B-O
thought VERB B-O
to PART B-O
oligomerize VERB B-O
γ PROPN B-AC
into ADP B-O
similar ADJ B-O
ring NOUN B-O
complexes NOUN B-O
[ PUNCT B-O
12,13 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
data NOUN B-O
was AUX B-O
normalized VERB B-O
to ADP B-O
the DET B-O
H/L PROPN B-AC
( PUNCT B-O
Heavy ADJ B-LF
/ SYM I-LF
Light NOUN I-LF
) PUNCT B-O
ratio NOUN B-O
of ADP B-O
the DET B-O
Pwp2p NOUN B-O
bait NOUN B-O
to ADP B-O
correct VERB B-O
for ADP B-O
the DET B-O
reduced VERB B-O
purification NOUN B-O
( PUNCT B-O
the DET B-O
H PROPN B-AC
ratio NOUN B-O
of ADP B-O
Pwp2p NOUN B-O
was AUX B-O
set VERB B-O
to ADP B-O
1 NUM B-O
) PUNCT B-O
. PUNCT B-O

Weight NOUN B-O
and CCONJ B-O
height NOUN B-O
were AUX B-O
measured VERB B-O
by ADP B-O
trained VERB B-O
professionals NOUN B-O
to ADP B-O
standardised ADJ B-O
protocols NOUN B-O
, PUNCT B-O
and CCONJ B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
as ADP B-O
weight NOUN B-O
divided VERB B-O
by ADP B-O
squared VERB B-O
height NOUN B-O
( PUNCT B-O
kg NOUN B-O
/ SYM B-O
m2 NOUN B-O
) PUNCT B-O
. PUNCT B-O

95 NUM B-O
% NOUN B-O
CI NOUN B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-O
interval NOUN B-O
; PUNCT B-O
HR PROPN B-AC
, PUNCT B-O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
PSA PROPN B-AC
, PUNCT B-O
prostate NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
antigen NOUN I-LF
; PUNCT B-O
pT NOUN B-O
, PUNCT B-O
pathological ADJ B-O
staging NOUN B-O
of ADP B-O
the DET B-O
primary ADJ B-O
tumor NOUN B-O
; PUNCT B-O
RP PROPN B-AC
, PUNCT B-O
radical ADJ B-LF
prostatectomy NOUN I-LF
. PUNCT B-O

Recent ADJ B-O
studies NOUN B-O
suggest VERB B-O
that SCONJ B-O
necroptosis NOUN B-O
is AUX B-O
mediated VERB B-O
by ADP B-O
receptor NOUN B-LF
interacting VERB I-LF
protein NOUN I-LF
3 NUM I-LF
( PUNCT B-O
RIP3)[7 PROPN B-AC
, PUNCT B-O
8 NUM B-O
] PUNCT B-O
. PUNCT B-O

SNP PROPN B-AC
: PUNCT B-O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphism NOUN I-LF
; PUNCT B-O
CTEPH PROPN B-AC
: PUNCT B-O
chronic ADJ B-LF
thromboembolic ADJ I-LF
pulmonary ADJ I-LF
hypertension NOUN I-LF
; PUNCT B-O
PE PROPN B-AC
: PUNCT B-O
pulmonary ADJ B-O
embolism NOUN B-O
; PUNCT B-O
PAH PROPN B-AC
: PUNCT B-O
pulmonary ADJ B-LF
arterial ADJ I-LF
hypertension NOUN I-LF
. PUNCT B-O

We PRON B-O
simulated VERB B-O
populations NOUN B-O
using VERB B-O
an DET B-O
agent NOUN B-LF
- PUNCT I-LF
based VERB I-LF
model NOUN I-LF
( PUNCT B-O
ABM PROPN B-AC
) PUNCT B-O
and CCONJ B-O
sampled VERB B-O
them PRON B-O
monthly ADV B-O
for ADP B-O
25 NUM B-O
years NOUN B-O
with ADP B-O
a DET B-O
total NOUN B-O
of ADP B-O
300 NUM B-O
time NOUN B-O
points NOUN B-O
, PUNCT B-O
where SCONJ B-O
each DET B-O
time NOUN B-O
point NOUN B-O
is AUX B-O
a DET B-O
snapshot NOUN B-O
of ADP B-O
changes NOUN B-O
accumulated VERB B-O
in ADP B-O
the DET B-O
parasite NOUN B-O
population NOUN B-O
during ADP B-O
a DET B-O
30 NUM B-O
- PUNCT B-O
day NOUN B-O
period NOUN B-O
. PUNCT B-O

An DET B-O
analysis NOUN B-O
of ADP B-O
the DET B-O
putative ADJ B-O
cis ADJ B-O
- ADJ B-O
regulatory ADJ B-O
elements NOUN B-O
that SCONJ B-O
were AUX B-O
present ADJ B-O
in ADP B-O
the DET B-O
promoter NOUN B-O
sequences NOUN B-O
of ADP B-O
aquaporin NOUN B-O
genes NOUN B-O
belonging VERB B-O
to ADP B-O
TIP PROPN B-AC
subfamily NOUN B-O
led VERB B-O
to ADP B-O
the DET B-O
conclusion NOUN B-O
that SCONJ B-O
their PRON B-O
expression NOUN B-O
may AUX B-O
be AUX B-O
regulated VERB B-O
in ADP B-O
response NOUN B-O
to ADP B-O
hormones NOUN B-O
such ADJ B-O
as SCONJ B-O
abscisic NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
ABA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
methyl NOUN B-LF
jasmonate NOUN I-LF
( PUNCT B-O
MeJA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
auxin NOUN B-O
and CCONJ B-O
gibberellin NOUN B-O
( PUNCT B-O
GA PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
presence NOUN B-O
of ADP B-O
ABRE PROPN B-O
in ADP B-O
the DET B-O
investigated VERB B-O
promoters NOUN B-O
suggests VERB B-O
a DET B-O
possible ADJ B-O
role NOUN B-O
of ADP B-O
ABA PROPN B-AC
in ADP B-O
the DET B-O
control NOUN B-O
of ADP B-O
HvTIP PROPN B-O
expression NOUN B-O
as SCONJ B-O
has AUX B-O
already ADV B-O
been AUX B-O
reported VERB B-O
for ADP B-O
some DET B-O
TIP PROPN B-AC
genes NOUN B-O
in ADP B-O
barley NOUN B-O
. PUNCT B-O

CS PROPN B-AC
, PUNCT B-O
cesarean ADJ B-LF
section NOUN I-LF
; PUNCT B-O
HELLP PROPN B-AC
, PUNCT B-O
hemolysis NOUN B-O
, PUNCT B-O
elevated ADJ B-O
liver NOUN B-O
enzymes NOUN B-O
, PUNCT B-O
low ADJ B-O
platelet NOUN B-O
count NOUN B-O
. PUNCT B-O

We PRON B-O
assessed VERB B-O
the DET B-O
efficiency NOUN B-O
of ADP B-O
gene NOUN B-O
discovery NOUN B-O
by ADP B-O
calculating VERB B-O
the DET B-O
percentage NOUN B-O
of ADP B-O
known VERB B-O
genes NOUN B-O
tagged VERB B-O
as ADP B-O
a DET B-O
function NOUN B-O
of ADP B-O
read VERB B-O
number NOUN B-O
for ADP B-O
MF PROPN B-AC
and CCONJ B-O
compared VERB B-O
this DET B-O
value NOUN B-O
to ADP B-O
the DET B-O
rate NOUN B-O
of ADP B-O
gene NOUN B-O
discovery NOUN B-O
obtained VERB B-O
by ADP B-O
expressed VERB B-LF
sequence NOUN I-LF
tags NOUN I-LF
( PUNCT B-O
ESTs PROPN B-AC
) PUNCT B-O
for ADP B-O
sorghum NOUN B-O
( PUNCT B-O
Figure PROPN B-O
2 NUM B-O
) PUNCT B-O
. PUNCT B-O

Alternative ADJ B-O
, PUNCT B-O
community NOUN B-O
- PUNCT B-O
based VERB B-O
approaches NOUN B-O
are AUX B-O
required VERB B-O
to PART B-O
meet VERB B-O
the DET B-O
Joint PROPN B-LF
United PROPN I-LF
Nations PROPN I-LF
Programme PROPN I-LF
on ADP I-LF
HIV PROPN I-LF
/ SYM I-LF
AIDS PROPN I-LF
( PUNCT B-O
UNAIDS PROPN B-AC
) PUNCT B-O
target NOUN B-O
of ADP B-O
diagnosing VERB B-O
90 NUM B-O
% NOUN B-O
of ADP B-O
those PRON B-O
living VERB B-O
with ADP B-O
HIV PROPN B-O
by ADP B-O
2020 NUM B-O
in ADP B-O
this DET B-O
age NOUN B-O
group NOUN B-O
. PUNCT B-O

Baht PROPN B-O
can AUX B-O
be AUX B-O
converted VERB B-O
to ADP B-O
$ SYM B-O
US PROPN B-O
by ADP B-O
dividing VERB B-O
by ADP B-O
31.16 NUM B-O
; PUNCT B-O
T1MI PROPN B-AC
, PUNCT B-O
type NOUN B-O
1 NUM B-O
myocardial ADJ B-LF
infarction NOUN I-LF
; PUNCT B-O
ASCVD PROPN B-AC
, PUNCT B-O
atherosclerotic ADJ B-LF
cardiovascular ADJ I-LF
disease NOUN I-LF
; PUNCT B-O
QALY PROPN B-AC
, PUNCT B-O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
- PUNCT I-LF
year NOUN I-LF
; PUNCT B-O
ICER PROPN B-AC
, PUNCT B-O
incremental ADJ B-LF
cost NOUN I-LF
- PUNCT I-LF
effectiveness NOUN I-LF
ratio NOUN I-LF
; PUNCT B-O
Rama PROPN B-AC
, PUNCT B-O
Ramathibodi PROPN B-LF
- PUNCT I-LF
Electricity PROPN I-LF
Generating PROPN I-LF
Authority PROPN I-LF
of ADP I-LF
Thailand PROPN I-LF
. PUNCT B-O

Since SCONJ B-O
histone NOUN B-O
acetylation NOUN B-O
is AUX B-O
controlled VERB B-O
by ADP B-O
the DET B-O
balance NOUN B-O
of ADP B-O
histone NOUN B-LF
acetyltransferases NOUN I-LF
( PUNCT B-O
HATs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
deacetylases NOUN B-O
( PUNCT B-O
HDACs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
we PRON B-O
next ADV B-O
asked VERB B-O
whether SCONJ B-O
blocking VERB B-O
HDAC PROPN B-AC
function NOUN B-O
would AUX B-O
reactivate VERB B-O
IFN PROPN B-AC
- PUNCT B-O
λ PUNCT B-O
receptor NOUN B-O
expression NOUN B-O
in ADP B-O
nonresponsive ADJ B-O
cells NOUN B-O
. PUNCT B-O

In ADP B-O
the DET B-O
present ADJ B-O
study NOUN B-O
, PUNCT B-O
we PRON B-O
investigated VERB B-O
the DET B-O
effect NOUN B-O
of ADP B-O
a DET B-O
sub ADJ B-O
- PUNCT B-O
chronic ADJ B-O
treatment NOUN B-O
with ADP B-O
local ADJ B-LF
cryotherapy NOUN I-LF
( PUNCT B-O
LC PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
widely ADV B-O
- PUNCT B-O
used VERB B-O
rat NOUN B-O
model NOUN B-O
of ADP B-O
adjuvant NOUN B-LF
- PUNCT I-LF
induced VERB I-LF
arthritis NOUN I-LF
( PUNCT B-O
AIA PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Two NUM B-O
modalities NOUN B-O
of ADP B-O
cryotherapy NOUN B-O
were AUX B-O
compared VERB B-O
: PUNCT B-O
local ADJ B-O
ice NOUN B-O
and CCONJ B-O
cold ADJ B-O
spray NOUN B-O
application NOUN B-O
. PUNCT B-O

HRs PROPN B-AC
were AUX B-O
adjusted VERB B-O
for ADP B-O
age NOUN B-O
, PUNCT B-O
sex NOUN B-O
, PUNCT B-O
total ADJ B-O
energy NOUN B-O
intake NOUN B-O
, PUNCT B-O
education NOUN B-O
, PUNCT B-O
physical ADJ B-O
activity NOUN B-O
, PUNCT B-O
smoking NOUN B-O
status NOUN B-O
, PUNCT B-O
alcohol NOUN B-O
intake NOUN B-O
, PUNCT B-O
and CCONJ B-O
BMI PROPN B-AC
. PUNCT B-O

BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
HR PROPN B-AC
, PUNCT B-O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
MetS PROPN B-AC
, PUNCT B-O
metabolic ADJ B-LF
syndrome NOUN I-LF
; PUNCT B-O
uPDI PROPN B-AC
, PUNCT B-O
unhealthful ADJ B-LF
plant NOUN I-LF
- PUNCT I-LF
based VERB I-LF
diet NOUN I-LF
index NOUN I-LF
. PUNCT B-O

CHW PROPN B-AC
, PUNCT B-O
community NOUN B-LF
health NOUN I-LF
worker NOUN I-LF
; PUNCT B-O
DV PROPN B-O
, PUNCT B-O
drug NOUN B-O
vendor NOUN B-O
/ SYM B-O
shop NOUN B-O
; PUNCT B-O
HP PROPN B-O
, PUNCT B-O
healthcare NOUN B-O
provider NOUN B-O
; PUNCT B-O
MA PROPN B-O
, PUNCT B-O
medical ADJ B-O
assistant NOUN B-O
; PUNCT B-O
MD PROPN B-O
, PUNCT B-O
medical ADJ B-O
doctor NOUN B-O
; PUNCT B-O
NA PROPN B-O
, PUNCT B-O
not PART B-O
reported VERB B-O
by ADP B-O
study NOUN B-O
authors NOUN B-O
; PUNCT B-O
pharm NOUN B-O
, PUNCT B-O
pharmacist NOUN B-O
( PUNCT B-O
trained VERB B-O
) PUNCT B-O
; PUNCT B-O
PSI PROPN B-O
, PUNCT B-O
Population PROPN B-O
Services PROPN B-O
International PROPN B-O
Research PROPN B-O
and CCONJ B-O
Metrics PROPN B-O
; PUNCT B-O
PW PROPN B-O
, PUNCT B-O
pregnant ADJ B-O
women NOUN B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
was AUX B-O
undertaken VERB B-O
in ADP B-O
Kenyatta PROPN B-LF
National PROPN I-LF
Hospital PROPN I-LF
( PUNCT B-O
KNH PROPN B-AC
) PUNCT B-O
-the DET B-O
largest ADJ B-O
public ADJ B-O
tertiary ADJ B-O
referral NOUN B-O
centre NOUN B-O
in ADP B-O
East PROPN B-O
& CCONJ B-O
Central PROPN B-O
Africa PROPN B-O
— PUNCT B-O
to PART B-O
help AUX B-O
bridge VERB B-O
existing VERB B-O
AMR PROPN B-AC
knowledge NOUN B-O
and CCONJ B-O
practice NOUN B-O
gaps NOUN B-O
. PUNCT B-O

We PRON B-O
extracted VERB B-O
individuals NOUN B-O
’ PUNCT B-O
demographic ADJ B-O
and CCONJ B-O
residential ADJ B-O
information NOUN B-O
, PUNCT B-O
including VERB B-O
age NOUN B-O
, PUNCT B-O
sex NOUN B-O
, PUNCT B-O
residence NOUN B-O
, PUNCT B-O
income NOUN B-O
quintile NOUN B-O
, PUNCT B-O
and CCONJ B-O
whether SCONJ B-O
the DET B-O
individual NOUN B-O
was AUX B-O
resident NOUN B-O
of ADP B-O
a DET B-O
long ADJ B-LF
- PUNCT I-LF
term NOUN I-LF
care NOUN I-LF
( PUNCT B-O
LTC PROPN B-AC
) PUNCT B-O
facility NOUN B-O
90 NUM B-O
days NOUN B-O
prior ADV B-O
to ADP B-O
the DET B-O
testing NOUN B-O
date NOUN B-O
from ADP B-O
the DET B-O
database NOUN B-O
. PUNCT B-O

The DET B-O
studied VERB B-O
responses NOUN B-O
( PUNCT B-O
dependent ADJ B-O
variables NOUN B-O
) PUNCT B-O
were AUX B-O
the DET B-O
dissolution NOUN B-LF
efficiency NOUN I-LF
% NOUN B-O
at ADP B-O
10 NUM B-O
min PROPN B-AC
( PUNCT B-O
Y1 PROPN B-O
: PUNCT B-O
DE PROPN B-AC
( PUNCT B-O
10 NUM B-O
min PROPN B-AC
) PUNCT B-O
% NOUN B-O
) PUNCT B-O
, PUNCT B-O
the DET B-O
dissolution NOUN B-LF
efficiency NOUN I-LF
% NOUN B-O
at ADP B-O
30 NUM B-O
min PROPN B-AC
( PUNCT B-O
Y2 PROPN B-O
: PUNCT B-O
DE PROPN B-AC
( PUNCT B-O
30 NUM B-O
min PROPN B-AC
) PUNCT B-O
% NOUN B-O
) PUNCT B-O
, PUNCT B-O
the DET B-O
mean ADJ B-LF
dissolution NOUN I-LF
time NOUN I-LF
( PUNCT B-O
Y3 NOUN B-O
: PUNCT B-O
MDT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
disintegration NOUN B-LF
time NOUN I-LF
( PUNCT B-O
Y4 PROPN B-O
: PUNCT B-O
DT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
wetting NOUN B-LF
time NOUN I-LF
( PUNCT B-O
Y5 NOUN B-O
: PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Responses NOUN B-O
of ADP B-O
the DET B-O
prepared VERB B-O
ODTs PROPN B-AC
are AUX B-O
listed VERB B-O
in ADP B-O
Table NOUN B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
in ADP B-O
S1 PROPN B-O
File PROPN B-O
. PUNCT B-O

This PRON B-O
is AUX B-O
in ADP B-O
contrast NOUN B-O
to ADP B-O
the DET B-O
traditional ADJ B-O
physician NOUN B-O
- PUNCT B-O
assessed VERB B-O
Expanded PROPN B-LF
Disability PROPN I-LF
Status PROPN I-LF
Scale PROPN I-LF
( PUNCT B-O
EDSS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
the DET B-O
primary ADJ B-O
outcome NOUN B-O
favoured VERB B-O
in ADP B-O
most ADJ B-O
MS PROPN B-AC
trials NOUN B-O
despite SCONJ B-O
several ADJ B-O
well ADV B-O
- PUNCT B-O
documented VERB B-O
limitations NOUN B-O
, PUNCT B-O
including VERB B-O
poor ADJ B-O
interrater NOUN B-O
and CCONJ B-O
intrarater ADJ B-O
reliability NOUN B-O
and CCONJ B-O
a DET B-O
limited ADJ B-O
sensitivity NOUN B-O
to ADP B-O
change NOUN B-O
over ADP B-O
the DET B-O
time NOUN B-O
frame NOUN B-O
of ADP B-O
2–3 NUM B-O
years NOUN B-O
, PUNCT B-O
especially ADV B-O
in ADP B-O
progressive ADJ B-O
MS PROPN B-AC
[ PUNCT B-O
16–20 NUM B-O
] PUNCT B-O
. PUNCT B-O

Compared VERB B-O
with ADP B-O
LPS PROPN B-AC
alone ADV B-O
, PUNCT B-O
at ADP B-O
Vm PROPN B-AC
values NOUN B-O
negative ADJ B-O
from ADP B-O
the DET B-O
reversal NOUN B-LF
NCX PROPN B-AC
potential NOUN I-LF
( PUNCT B-O
Erev PROPN B-AC
) PUNCT B-O
, PUNCT B-O
additional ADJ B-O
HS PROPN B-AC
exposure NOUN B-O
enhanced VERB B-O
NCX PROPN B-AC
inward ADJ B-O
current NOUN B-O
( PUNCT B-O
Fig PROPN B-O
4C NUM B-O
) PUNCT B-O
. PUNCT B-O

Altogether ADV B-O
, PUNCT B-O
this PRON B-O
suggests VERB B-O
that SCONJ B-O
NCX PROPN B-AC
mediates VERB B-O
Na+ NOUN B-O
entry NOUN B-O
. PUNCT B-O

The DET B-O
location NOUN B-O
of ADP B-O
weaker ADJ B-O
lipid NOUN B-O
binding VERB B-O
sites NOUN B-O
is AUX B-O
therefore ADV B-O
usually ADV B-O
observed VERB B-O
using VERB B-O
classical ADJ B-O
molecular ADJ B-LF
dynamics NOUN I-LF
( PUNCT B-O
MD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

A DET B-O
planned VERB B-O
individual ADJ B-LF
participant NOUN I-LF
data NOUN I-LF
( PUNCT B-O
IPD PROPN B-AC
) PUNCT B-O
meta NOUN B-O
- NOUN B-O
analysis NOUN B-O
( PUNCT B-O
PROSPERO PROPN B-O
CRD42017072683 NUM B-O
) PUNCT B-O
may AUX B-O
prove VERB B-O
helpful ADJ B-O
to PART B-O
further ADV B-O
explore VERB B-O
possible ADJ B-O
sex NOUN B-O
differences NOUN B-O
in ADP B-O
the DET B-O
effects NOUN B-O
of ADP B-O
macronutrient NOUN B-O
supplements NOUN B-O
in ADP B-O
human ADJ B-O
infants NOUN B-O
born VERB B-O
small ADJ B-O
. PUNCT B-O

We PRON B-O
used VERB B-O
a DET B-O
novel ADJ B-O
in ADP B-O
vitro X B-O
assay NOUN B-O
( PUNCT B-O
for ADP B-O
gamma NOUN B-LF
- NOUN I-LF
interferon NOUN I-LF
[ PUNCT B-O
IFN-γ PROPN B-AC
] PUNCT B-O
) PUNCT B-O
release NOUN B-O
to PART B-O
establish VERB B-O
LTBI PROPN B-AC
and CCONJ B-O
a DET B-O
questionnaire NOUN B-O
to PART B-O
address VERB B-O
risk NOUN B-O
factors NOUN B-O
. PUNCT B-O

Fenland PROPN B-O
Study PROPN B-O
participants NOUN B-O
undergo VERB B-O
a DET B-O
health NOUN B-O
assessment NOUN B-O
, PUNCT B-O
and CCONJ B-O
blood NOUN B-O
samples NOUN B-O
are AUX B-O
collected VERB B-O
for ADP B-O
the DET B-O
genotyping NOUN B-O
of ADP B-O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT B-O
SNPs PROPN B-AC
) PUNCT B-O
associated VERB B-O
with ADP B-O
type NOUN B-O
2 NUM B-O
diabetes NOUN B-O
. PUNCT B-O

The DET B-O
ratio NOUN B-LF
of ADP I-LF
nonsynonymous ADJ I-LF
to PART I-LF
synonymous ADJ I-LF
substitutions NOUN I-LF
( PUNCT B-O
dN/dS PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
in ADP B-O
phylogenetic ADJ B-LF
analysis NOUN I-LF
by ADP I-LF
maximum ADJ I-LF
likelihood NOUN I-LF
( PUNCT B-O
PAML PROPN B-AC
) PUNCT B-O
software NOUN B-O
[ X B-O
39 X B-O
] X B-O
using VERB B-O
a DET B-O
two NUM B-O
- PUNCT B-O
ratio NOUN B-O
maximum ADJ B-O
- PUNCT B-O
likelihood NOUN B-O
analysis NOUN B-O
between ADP B-O
the DET B-O
human ADJ B-LF
haplotype NOUN I-LF
's PART I-LF
most ADV I-LF
recent ADJ I-LF
common ADJ I-LF
ancestor NOUN I-LF
( PUNCT B-O
HH PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
human ADJ B-O
- PUNCT B-O
chimpanzee NOUN B-O
-MRCAMRCA PROPN B-AC
( PUNCT B-O
Figure PROPN B-O
5B NUM B-O
) PUNCT B-O
. PUNCT B-O

This DET B-O
measurement NOUN B-O
, PUNCT B-O
which PRON B-O
only ADV B-O
evaluates VERB B-O
fixed VERB B-O
changes NOUN B-O
, PUNCT B-O
is AUX B-O
used VERB B-O
to PART B-O
determine VERB B-O
selective ADJ B-O
pressures NOUN B-O
in ADP B-O
a DET B-O
coding VERB B-O
region NOUN B-O
, PUNCT B-O
where SCONJ B-O
values NOUN B-O
> ADP B-O
1 NUM B-O
suggest VERB B-O
positive ADJ B-O
selection NOUN B-O
, PUNCT B-O
while SCONJ B-O
values NOUN B-O
< ADP B-O
1 NUM B-O
indicate VERB B-O
purifying VERB B-O
selection NOUN B-O
. PUNCT B-O

Fig NOUN B-O
5 NUM B-O
shows VERB B-O
immunohistochemistry NOUN B-LF
( PUNCT B-O
IHC PROPN B-AC
) PUNCT B-O
results NOUN B-O
in ADP B-O
benign ADJ B-O
prostate NOUN B-O
tissue NOUN B-O
and CCONJ B-O
prostate NOUN B-O
adenocarcinoma NOUN B-O
according VERB B-O
to ADP B-O
pT NOUN B-O
stage NOUN B-O
and CCONJ B-O
Gleason PROPN B-O
score NOUN B-O
. PUNCT B-O

Among ADP B-O
the DET B-O
approximately ADV B-O
70 NUM B-O
members NOUN B-O
in ADP B-O
the DET B-O
TRIM PROPN B-AC
family NOUN B-O
, PUNCT B-O
TRIM59 PROPN B-O
stood VERB B-O
out ADP B-O
as ADP B-O
one NUM B-O
of ADP B-O
the DET B-O
most ADV B-O
differentially ADV B-O
expressed VERB B-O
genes NOUN B-O
, PUNCT B-O
with ADP B-O
its PRON B-O
expression NOUN B-O
ubiquitously ADV B-O
up ADV B-O
- ADJ B-O
regulated VERB B-O
by ADP B-O
1.6- NUM B-O
to PART B-O
6.3 NUM B-O
- ADJ B-O
fold NOUN B-O
in ADP B-O
12 NUM B-O
analyzed VERB B-O
cancer NOUN B-O
types NOUN B-O
compared VERB B-O
with ADP B-O
the DET B-O
adjacent ADJ B-O
normal ADJ B-O
tissues NOUN B-O
( PUNCT B-O
Figs PROPN B-O
1A NOUN B-O
and CCONJ B-O
S1A PROPN B-O
) PUNCT B-O
. PUNCT B-O

Particularly ADV B-O
, PUNCT B-O
in ADP B-O
breast NOUN B-LF
invasive ADJ I-LF
carcinoma NOUN I-LF
( PUNCT B-O
BRCA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
TRIM59 PROPN B-O
mRNA NOUN B-O
level NOUN B-O
was AUX B-O
significantly ADV B-O
increased VERB B-O
in ADP B-O
tumor NOUN B-O
sites NOUN B-O
( PUNCT B-O
red ADJ B-O
plot NOUN B-O
) PUNCT B-O
compared VERB B-O
with ADP B-O
its PRON B-O
expression NOUN B-O
in ADP B-O
normal ADJ B-O
adjacent ADJ B-O
tissues NOUN B-O
( PUNCT B-O
blue ADJ B-O
plot NOUN B-O
; PUNCT B-O
fold NOUN B-O
change NOUN B-O
= SYM B-O
4.03 NUM B-O
, PUNCT B-O
P NOUN B-O
value NOUN B-O
= SYM B-O
2.9 NUM B-O
× PUNCT B-O
10−28 NUM B-O
; PUNCT B-O
S1A PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
analyses NOUN B-O
of ADP B-O
frailty NOUN B-O
categories NOUN B-O
, PUNCT B-O
only ADV B-O
the DET B-O
G-8 PROPN B-LF
Geriatric PROPN I-LF
Screening PROPN I-LF
Tool PROPN I-LF
( PUNCT B-O
G8 PROPN B-AC
) PUNCT B-O
score NOUN B-O
added VERB B-O
statistically ADV B-O
significant ADJ B-O
predictive ADJ B-O
value NOUN B-O
( PUNCT B-O
delta NOUN B-O
C NOUN B-O
: PUNCT B-O
1.6 NUM B-O
[ PUNCT B-O
95 NUM B-O
% NOUN B-O
CI NOUN B-O
: PUNCT B-O
0.4–2.8 NUM B-O
] PUNCT B-O
) PUNCT B-O
( PUNCT B-O
S10 PROPN B-O
Table PROPN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
March PROPN B-O
2016 NUM B-O
, PUNCT B-O
HRSA PROPN B-AC
awarded VERB B-O
$ SYM B-O
94 NUM B-O
million NUM B-O
through ADP B-O
the DET B-O
Substance PROPN B-LF
Abuse PROPN I-LF
Service PROPN I-LF
Expansion PROPN I-LF
( PUNCT B-O
SASE PROPN B-AC
) PUNCT B-O
supplemental ADJ B-O
grants NOUN B-O
to ADP B-O
271 NUM B-O
or CCONJ B-O
20 NUM B-O
% NOUN B-O
of ADP B-O
HCs PROPN B-AC
, PUNCT B-O
with ADP B-O
supplementary ADJ B-O
funding NOUN B-O
ranging VERB B-O
from ADP B-O
$ SYM B-O
217,000 NUM B-O
to ADP B-O
$ SYM B-O
406,000 NUM B-O
. PUNCT B-O

FisB PROPN B-AC
, PUNCT B-O
fission NOUN B-LF
protein NOUN I-LF
B. NOUN I-LF
Consistent ADJ B-O
with ADP B-O
this PRON B-O
, PUNCT B-O
ICP47 PROPN B-O
protects VERB B-O
HSV PROPN B-AC
- PUNCT B-O
infected VERB B-O
human ADJ B-O
fibroblasts NOUN B-O
from ADP B-O
destruction NOUN B-O
by ADP B-O
cytotoxic ADJ B-LF
T PROPN I-LF
lymphocytes NOUN I-LF
( PUNCT B-O
CTLs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
while SCONJ B-O
murine ADJ B-O
fibroblasts NOUN B-O
are AUX B-O
not PART B-O
protected VERB B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

These DET B-O
data NOUN B-O
were AUX B-O
then ADV B-O
analyzed VERB B-O
via ADP B-O
a DET B-O
one NUM B-O
- PUNCT B-O
way NOUN B-O
repeated VERB B-O
measures NOUN B-O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
( PUNCT B-O
ANOVA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
with ADP B-O
Fisher PROPN B-O
’s PART B-O
post X B-O
hoc X B-O
analysis NOUN B-O
of ADP B-O
each DET B-O
experimental ADJ B-O
treatment NOUN B-O
group NOUN B-O
compared VERB B-O
to ADP B-O
vehicle NOUN B-O
following VERB B-O
a DET B-O
significant ADJ B-O
ANOVA PROPN B-AC
( PUNCT B-O
P NOUN B-O
< ADP B-O
0.05 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
plotted VERB B-O
as ADP B-O
a DET B-O
mean NOUN B-O
± ADJ B-O
S.E.M. NOUN B-O
for ADP B-O
the DET B-O
group NOUN B-O
. PUNCT B-O

We PRON B-O
have AUX B-O
also ADV B-O
challenged VERB B-O
our PRON B-O
whole ADJ B-O
blood NOUN B-O
samples NOUN B-O
with ADP B-O
either CCONJ B-O
intact ADJ B-O
bacterial ADJ B-O
( PUNCT B-O
E.coli PROPN B-AC
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
virus NOUN B-O
( PUNCT B-O
HSV-1 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
rather ADV B-O
than ADP B-O
specific ADJ B-O
Toll NOUN B-LF
like ADP I-LF
receptor NOUN I-LF
( PUNCT B-O
TLR PROPN B-AC
) PUNCT B-O
agonists NOUN B-O
like ADP B-O
lipopolysaccharide NOUN B-LF
( PUNCT B-O
LPS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
since SCONJ B-O
we PRON B-O
considered VERB B-O
intact ADJ B-O
pathogens NOUN B-O
more ADV B-O
representative ADJ B-O
of ADP B-O
in X B-O
vivo X B-O
infections NOUN B-O
. PUNCT B-O

* PUNCT B-O
Value NOUN B-O
of ADP B-O
% NOUN B-O
DNA NOUN B-LF
repair NOUN I-LF
capacity NOUN I-LF
( PUNCT B-O
DRC PROPN B-AC
) PUNCT B-O
measured VERB B-O
in ADP B-O
lymphocytes NOUN B-O
expressed VERB B-O
as ADP B-O
mean NOUN B-O
( PUNCT B-O
X NOUN B-O
¯ NOUN B-O
) PUNCT B-O
, PUNCT B-O
± NOUN B-O
1 NUM B-O
standard ADJ B-O
deviation NOUN B-O
( PUNCT B-O
SD NOUN B-O
) PUNCT B-O
and CCONJ B-O
median ADJ B-O
values NOUN B-O
including VERB B-O
percentile NOUN B-O
25 NUM B-O
( PUNCT B-O
P25 NUM B-O
) PUNCT B-O
and CCONJ B-O
percentile NOUN B-O
75 NUM B-O
( PUNCT B-O
P75 NUM B-O
) PUNCT B-O
. PUNCT B-O

Those DET B-O
incident NOUN B-O
cases NOUN B-O
with ADP B-O
sequelae NOUN B-O
( PUNCT B-O
or CCONJ B-O
diseased ADJ B-O
individuals NOUN B-O
) PUNCT B-O
were AUX B-O
assigned VERB B-O
years NOUN B-LF
of ADP I-LF
life NOUN I-LF
lost VERB I-LF
( PUNCT B-O
YLLs PROPN B-AC
) PUNCT B-O
if SCONJ B-O
fatal ADJ B-O
or CCONJ B-O
years NOUN B-LF
lived VERB I-LF
with ADP I-LF
disability NOUN I-LF
( PUNCT B-O
YLDs PROPN B-AC
) PUNCT B-O
with ADP B-O
a DET B-O
disability NOUN B-LF
weight NOUN I-LF
( PUNCT B-O
DW PROPN B-AC
) PUNCT B-O
that PRON B-O
depended VERB B-O
on ADP B-O
the DET B-O
severity NOUN B-O
of ADP B-O
the DET B-O
disease NOUN B-O
. PUNCT B-O

Nutrient NOUN B-O
intake NOUN B-O
stimulates VERB B-O
production NOUN B-O
of ADP B-O
circulating VERB B-O
Drosophila PROPN B-LF
insulin NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
peptides NOUN I-LF
( PUNCT B-O
Dilps PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
activate VERB B-O
the DET B-O
insulin NOUN B-O
/ SYM B-O
IGF-1 PROPN B-AC
receptor NOUN B-O
( PUNCT B-O
InR PROPN B-O
) PUNCT B-O
, PUNCT B-O
leading VERB B-O
to ADP B-O
the DET B-O
recruitment NOUN B-O
of ADP B-O
the DET B-O
phosphatidyl NOUN B-LF
inositol-3 NOUN I-LF
- PUNCT I-LF
kinase NOUN I-LF
( PUNCT B-O
PI3K PROPN B-AC
— PUNCT B-O
composed VERB B-O
of ADP B-O
two NUM B-O
subunits NOUN B-O
, PUNCT B-O
p60 NOUN B-O
and CCONJ B-O
p110 NOUN B-O
) PUNCT B-O
, PUNCT B-O
which PRON B-O
coverts VERB B-O
phosphatidyl NOUN B-LF
inositol NOUN I-LF
phosphate NOUN I-LF
( PUNCT B-O
PIP)2 PROPN B-AC
to ADP B-O
PIP3 PROPN B-O
at ADP B-O
the DET B-O
plasma NOUN B-O
membrane NOUN B-O
of ADP B-O
signal NOUN B-O
- PUNCT B-O
receiving VERB B-O
cells NOUN B-O
( PUNCT B-O
a DET B-O
process NOUN B-O
antagonised VERB B-O
by ADP B-O
the DET B-O
phosphatase NOUN B-LF
and CCONJ I-LF
tensin NOUN I-LF
homolog NOUN I-LF
PTEN PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
3 NUM B-O
, PUNCT B-O
20–30 NUM B-O
] PUNCT B-O
. PUNCT B-O

AMR PROPN B-AC
, PUNCT B-O
asthma NOUN B-LF
medication NOUN I-LF
ratio NOUN I-LF
; PUNCT B-O
CI PROPN B-O
, PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
; PUNCT B-O
GAM PROPN B-AC
, PUNCT B-O
generalised ADJ B-LF
additive ADJ I-LF
model NOUN I-LF
; PUNCT B-O
WIMD PROPN B-AC
, PUNCT B-O
Welsh PROPN B-LF
Index PROPN I-LF
of ADP I-LF
Multiple PROPN I-LF
Deprivation PROPN I-LF
. PUNCT B-O

ALT PROPN B-AC
serum NOUN B-O
concentration NOUN B-O
was AUX B-O
analyzed VERB B-O
as SCONJ B-O
categorical ADJ B-O
variable NOUN B-O
in ADP B-O
this DET B-O
model NOUN B-O
, PUNCT B-O
as SCONJ B-O
indicated VERB B-O
. PUNCT B-O

w PROPN B-O
, PUNCT B-O
women NOUN B-O
; PUNCT B-O
m PROPN B-O
, PUNCT B-O
men NOUN B-O
; PUNCT B-O
ALT PROPN B-AC
, PUNCT B-O
alanine NOUN B-LF
aminotransferase NOUN I-LF
; PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
γGT PROPN B-O
, PUNCT B-O
γ PUNCT B-O
- PUNCT B-O
glutamyl NOUN B-O
transferase NOUN B-O
; PUNCT B-O
IFN PROPN B-AC
, PUNCT B-O
interferon NOUN B-LF
; PUNCT B-O
INR PROPN B-AC
, PUNCT B-O
international ADJ B-LF
normalized ADJ I-LF
ratio NOUN I-LF
; PUNCT B-O
IFN PROPN B-AC
, PUNCT B-O
interferon NOUN B-LF
; PUNCT B-O
ULN PROPN B-AC
, PUNCT B-O
upper ADJ B-LF
limit NOUN I-LF
of ADP I-LF
normal ADJ I-LF
. PUNCT B-O

In ADP B-O
spite NOUN B-O
of ADP B-O
the DET B-O
considerable ADJ B-O
body NOUN B-O
of ADP B-O
research NOUN B-O
on ADP B-O
NDDs PROPN B-AC
such ADJ B-O
as ADP B-O
Alzheimer PROPN B-LF
’s PART I-LF
disease NOUN I-LF
( PUNCT B-O
AD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
amyotrophic ADJ B-LF
lateral ADJ I-LF
sclerosis NOUN I-LF
( PUNCT B-O
ALS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Huntington PROPN B-LF
’s PART I-LF
disease NOUN I-LF
( PUNCT B-O
HD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
multiple ADJ B-LF
sclerosis NOUN I-LF
( PUNCT B-O
MS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Parkinson PROPN B-LF
’s PART I-LF
disease NOUN I-LF
( PUNCT B-O
PD PROPN B-AC
) PUNCT B-O
and CCONJ B-O
schizophrenia NOUN B-LF
( PUNCT B-O
SCHIZ PROPN B-AC
) PUNCT B-O
, PUNCT B-O
effective ADJ B-O
treatment NOUN B-O
for ADP B-O
preventing VERB B-O
the DET B-O
progressive ADJ B-O
neuronal ADJ B-O
loss NOUN B-O
is AUX B-O
yet ADV B-O
to PART B-O
be AUX B-O
available ADJ B-O
[ PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

LAM PROPN B-AC
, PUNCT B-O
lipoarabinomannan NOUN B-LF
assay NOUN I-LF
; PUNCT B-O
TB PROPN B-AC
, PUNCT B-O
tuberculosis NOUN B-LF
; PUNCT B-O
Xpert PROPN B-AC
, PUNCT B-O
Xpert PROPN B-LF
MTB PROPN I-LF
Xpert PROPN B-AC
/ SYM I-LF
MTB PROPN B-AC
RIF PROPN I-LF
assay NOUN I-LF
. PUNCT B-O

“ PUNCT B-O
… PUNCT B-O
any DET B-O
work NOUN B-O
[ X B-O
done VERB B-O
] X B-O
PA PROPN B-AC
[ X B-O
posteroanterior ADJ B-LF
] X B-O
, PUNCT B-O
especially ADV B-O
chests NOUN B-O
, PUNCT B-O
I PRON B-O
always ADV B-O
like ADP B-O
to PART B-O
have AUX B-O
a DET B-O
[ X B-O
radiopaque ADJ B-O
] X B-O
marker NOUN B-O
on ADP B-O
, PUNCT B-O
or CCONJ B-O
sinuses NOUN B-O
or CCONJ B-O
skulls NOUN B-O
because SCONJ B-O
if SCONJ B-O
you PRON B-O
do AUX B-O
get VERB B-O
dextrocardia NOUN B-O
or CCONJ B-O
something PRON B-O
like ADP B-O
that SCONJ B-O
… PUNCT B-O
you PRON B-O
can AUX B-O
stand VERB B-O
in ADP B-O
front NOUN B-O
of ADP B-O
the DET B-O
… PUNCT B-O
film NOUN B-O
[ X B-O
detector NOUN B-O
] X B-O
where SCONJ B-O
your PRON B-O
marker NOUN B-O
was AUX B-O
and CCONJ B-O
check VERB B-O
, PUNCT B-O
was AUX B-O
it PRON B-O
a DET B-O
left NOUN B-O
or CCONJ B-O
right NOUN B-O
and CCONJ B-O
then ADV B-O
double ADV B-O
check VERB B-O
yourself PRON B-O
that SCONJ B-O
you PRON B-O
have AUX B-O
actually ADV B-O
labelled VERB B-O
it PRON B-O
correctly ADV B-O
. PUNCT B-O

Fluorescence NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
cell NOUN I-LF
sorting NOUN I-LF
( PUNCT B-O
FACS PROPN B-AC
) PUNCT B-O
sorting NOUN B-O
to PART B-O
enrich VERB B-O
for ADP B-O
glioma NOUN B-O
stem NOUN B-O
cells NOUN B-O
has AUX B-O
relied VERB B-O
on ADP B-O
the DET B-O
presence NOUN B-O
of ADP B-O
the DET B-O
glycosylated VERB B-O
form NOUN B-O
of ADP B-O
the DET B-O
cell NOUN B-O
surface NOUN B-O
marker NOUN B-O
CD133 NOUN B-O
( PUNCT B-O
Prominin-1 NOUN B-O
): PUNCT B-O
a DET B-O
protein NOUN B-O
whose DET B-O
role NOUN B-O
in ADP B-O
tumorigenesis NOUN B-O
and CCONJ B-O
glioma NOUN B-O
biology NOUN B-O
remains VERB B-O
unclear ADJ B-O
[ PUNCT B-O
27 NUM B-O
] PUNCT B-O
. PUNCT B-O

Among ADP B-O
the DET B-O
methodologies NOUN B-O
used VERB B-O
to ADP B-O
ascertain VERB B-O
cause NOUN B-LF
of ADP I-LF
death NOUN I-LF
( PUNCT B-O
CoD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
those PRON B-O
derived VERB B-O
from ADP B-O
the DET B-O
verbal ADJ B-O
autopsy NOUN B-O
lack VERB B-O
specificity NOUN B-O
with ADP B-O
regard NOUN B-O
to ADP B-O
most ADJ B-O
biological ADJ B-O
causes NOUN B-O
of ADP B-O
death NOUN B-O
. PUNCT B-O

EASI PROPN B-AC
, PUNCT B-O
Eczema PROPN B-LF
Area PROPN I-LF
and CCONJ I-LF
Severity PROPN I-LF
Index PROPN I-LF
. PUNCT B-O

We PRON B-O
found VERB B-O
biological ADJ B-O
factors NOUN B-O
including VERB B-O
girls NOUN B-O
experiencing VERB B-O
early ADJ B-O
menarche NOUN B-O
, PUNCT B-O
having VERB B-O
lighter ADJ B-O
periods NOUN B-O
, PUNCT B-O
and CCONJ B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
; PUNCT B-O
household NOUN B-O
level NOUN B-O
factors NOUN B-O
including VERB B-O
being AUX B-O
unhappy ADJ B-O
at ADP B-O
home NOUN B-O
, PUNCT B-O
being AUX B-O
orphaned VERB B-O
, PUNCT B-O
and CCONJ B-O
coming VERB B-O
from ADP B-O
poorer ADJ B-O
households NOUN B-O
; PUNCT B-O
and CCONJ B-O
social ADJ B-O
factors NOUN B-O
including VERB B-O
experiencing VERB B-O
harassment NOUN B-O
for ADP B-O
sex NOUN B-O
both PRON B-O
in ADP B-O
and CCONJ B-O
out ADP B-O
of ADP B-O
school NOUN B-O
or CCONJ B-O
being AUX B-O
touched VERB B-O
indecently ADV B-O
were AUX B-O
significantly ADV B-O
associated VERB B-O
with ADP B-O
girls NOUN B-O
’ PUNCT B-O
sexual ADJ B-O
and CCONJ B-O
reproductive ADJ B-O
harms NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
pregnancy NOUN B-O
, PUNCT B-O
HSV-2 PROPN B-AC
, PUNCT B-O
and/or CCONJ B-O
HIV PROPN B-O
. PUNCT B-O

L1 PROPN B-O
, PUNCT B-O
L2 PROPN B-O
, PUNCT B-O
L3 PROPN B-O
= PUNCT B-O
Languages NOUN B-O
1–3 NUM B-O
. PUNCT B-O

fMRI PROPN B-AC
, PUNCT B-O
functional ADJ B-LF
MRI NOUN I-LF
; PUNCT B-O
lPL PROPN B-AC
, PUNCT B-O
left ADJ B-LF
parietal ADJ I-LF
lobe NOUN I-LF
; PUNCT B-O
POz PROPN B-AC
, PUNCT B-O
midline ADJ B-LF
posterior ADJ I-LF
location NOUN I-LF
according VERB I-LF
to ADP I-LF
the DET I-LF
10–20 NUM I-LF
system NOUN I-LF
electrode NOUN I-LF
location NOUN I-LF
; PUNCT B-O
rTMS PROPN B-AC
, PUNCT B-O
repetitive ADJ B-LF
transcranial ADJ I-LF
magnetic ADJ I-LF
stimulation NOUN I-LF
. PUNCT B-O

SFM PROPN B-AC
shows VERB B-O
result NOUN B-O
of ADP B-O
serum NOUN B-LF
free ADJ I-LF
medium NOUN I-LF
alone ADV B-O
( PUNCT B-O
baseline NOUN B-O
control NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
thalamus NOUN B-O
expression NOUN B-O
domain NOUN B-O
of ADP B-O
lhx9 NOUN B-O
overlaps VERB B-O
with ADP B-O
the DET B-O
pattern NOUN B-O
of ADP B-O
id2a NOUN B-O
in ADP B-O
the DET B-O
medial ADJ B-O
part NOUN B-O
of ADP B-O
the DET B-O
mantle NOUN B-LF
zone NOUN I-LF
( PUNCT B-O
g NOUN B-O
, PUNCT B-O
g′ NOUN B-O
, PUNCT B-O
black ADJ B-O
bar NOUN B-O
) PUNCT B-O
. PUNCT B-O

lef1 NOUN B-O
as ADP B-O
a DET B-O
marker NOUN B-O
of ADP B-O
post ADJ B-O
- NOUN B-O
mitotic ADJ B-O
thalamic ADJ B-O
neurons NOUN B-O
shows VERB B-O
co NOUN B-O
- NOUN B-O
expression NOUN B-O
with ADP B-O
lhx9 NOUN B-O
in ADP B-O
the DET B-O
MZ PROPN B-AC
( PUNCT B-O
i NOUN B-O
, PUNCT B-O
i′ NOUN B-O
; PUNCT B-O
black ADJ B-O
bar NOUN B-O
) PUNCT B-O
. PUNCT B-O

Two NUM B-O
- PUNCT B-O
month NOUN B-O
- PUNCT B-O
old ADJ B-O
Thy1 PROPN B-O
- PUNCT B-O
YFP PROPN B-AC
transgenic VERB B-O
mice NOUN B-O
expressing VERB B-O
yellow ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
YFP PROPN B-AC
) PUNCT B-O
in ADP B-O
layer NOUN B-LF
5 NUM I-LF
( PUNCT B-O
L5 PROPN B-AC
) PUNCT B-O
pyramidal ADJ B-O
neurons NOUN B-O
were AUX B-O
repeatedly ADV B-O
imaged VERB B-O
before ADP B-O
and CCONJ B-O
1 NUM B-O
to ADP B-O
4 NUM B-O
weeks NOUN B-O
after ADP B-O
peripheral ADJ B-O
nerve NOUN B-O
injury NOUN B-O
( PUNCT B-O
Fig NOUN B-O
3A NUM B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
the DET B-O
region NOUN B-O
of ADP B-O
S1 PROPN B-AC
corresponding VERB B-O
to ADP B-O
the DET B-O
SNI PROPN B-AC
surgery NOUN B-O
side NOUN B-O
, PUNCT B-O
we PRON B-O
found VERB B-O
a DET B-O
significant ADJ B-O
increase NOUN B-O
in ADP B-O
the DET B-O
elimination NOUN B-O
and CCONJ B-O
formation NOUN B-O
rates NOUN B-O
of ADP B-O
dendritic ADJ B-O
spines NOUN B-O
( PUNCT B-O
Fig NOUN B-O
3B NUM B-O
and CCONJ B-O
3C NUM B-O
) PUNCT B-O
. PUNCT B-O

Within ADP B-O
the DET B-O
first ADJ B-O
week NOUN B-O
after ADP B-O
surgery NOUN B-O
, PUNCT B-O
7.7 NUM B-O
± SYM B-O
0.6 NUM B-O
% NOUN B-O
of ADP B-O
dendritic ADJ B-O
spines NOUN B-O
were AUX B-O
eliminated VERB B-O
and CCONJ B-O
8.1 NUM B-O
± SYM B-O
0.5 NUM B-O
% NOUN B-O
were AUX B-O
formed VERB B-O
in ADP B-O
sham ADJ B-O
mice NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
11.4 NUM B-O
± SYM B-O
1.1 NUM B-O
% NOUN B-O
and CCONJ B-O
11.9 NUM B-O
± SYM B-O
1.1 NUM B-O
% NOUN B-O
of ADP B-O
dendritic ADJ B-O
spines NOUN B-O
were AUX B-O
eliminated VERB B-O
and CCONJ B-O
formed VERB B-O
in ADP B-O
SNI PROPN B-AC
mice NOUN B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O

Inhibitor-2 NOUN B-LF
( PUNCT B-O
I-2 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
highly ADV B-O
conserved ADJ B-O
protein NOUN B-O
, PUNCT B-O
interacts VERB B-O
with ADP B-O
the DET B-O
catalytic ADJ B-O
subunit NOUN B-O
of ADP B-O
protein NOUN B-LF
phosphatase NOUN I-LF
1 NUM I-LF
( PUNCT B-O
PP1 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
inhibits VERB B-O
its PRON B-O
catalytic ADJ B-O
activity NOUN B-O
in ADP B-O
vitro ADV B-O
[ PUNCT B-O
33 NUM B-O
] PUNCT B-O
. PUNCT B-O

HR NOUN B-O
, PUNCT B-O
Heart NOUN B-O
Rate NOUN B-O
; PUNCT B-O
SBP PROPN B-O
, PUNCT B-O
Systolic ADJ B-O
Blood NOUN B-O
Pressure NOUN B-O
; PUNCT B-O
DBP NOUN B-O
, PUNCT B-O
Diastolic ADJ B-O
Blood NOUN B-O
Pressure NOUN B-O
; PUNCT B-O
PP NOUN B-O
, PUNCT B-O
Pulse NOUN B-O
Pressure NOUN B-O
; PUNCT B-O
FFR PROPN B-AC
, PUNCT B-O
Fractional ADJ B-LF
Flow PROPN I-LF
reserve NOUN I-LF
; PUNCT B-O
CFVR PROPN B-AC
, PUNCT B-O
Coronary ADJ B-LF
Flow PROPN I-LF
Velocity PROPN I-LF
Reserve PROPN I-LF
; PUNCT B-O
sFCW PROPN B-AC
, PUNCT B-O
systolic ADJ B-LF
Forward ADJ I-LF
travelling VERB I-LF
Compression NOUN I-LF
Wave PROPN I-LF
; PUNCT B-O
dBEW PROPN B-AC
, PUNCT B-O
diastolic ADJ B-LF
Backward ADJ I-LF
travelling VERB I-LF
Expansion NOUN I-LF
Wave PROPN I-LF
( PUNCT B-O
Table PROPN B-O
C PROPN B-O
) PUNCT B-O
. PUNCT B-O

Univariate ADJ B-O
linear ADJ B-O
regression NOUN B-O
analyses NOUN B-O
of ADP B-O
baseline ADJ B-O
( PUNCT B-O
pre ADJ B-O
- ADJ B-O
PCI PROPN B-AC
) PUNCT B-O
sFCW PROPN B-AC
and CCONJ B-O
dBEW PROPN B-AC
cumulative ADJ B-O
intensity NOUN B-O
with ADP B-O
baseline ADJ B-O
haemodynamic ADJ B-O
and CCONJ B-O
patient ADJ B-O
variables NOUN B-O
. PUNCT B-O

FRET PROPN B-AC
, PUNCT B-O
Förster PROPN B-LF
resonance NOUN I-LF
energy NOUN I-LF
transfer NOUN I-LF
; PUNCT B-O
GP PROPN B-AC
, PUNCT B-O
EBOV NOUN B-LF
envelope NOUN I-LF
EBOV PROPN B-AC
glycoprotein NOUN I-LF
; PUNCT B-O
GPΔmuc PROPN B-AC
, PUNCT B-O
GP PROPN B-LF
with ADP I-LF
GP PROPN B-AC
the DET I-LF
mucin NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
domain NOUN I-LF
deleted VERB I-LF
; PUNCT B-O
MD PROPN B-AC
, PUNCT B-O
molecular ADJ B-LF
dynamics NOUN I-LF
. PUNCT B-O

The DET B-O
apparent ADJ B-LF
digestibility NOUN I-LF
coefficients NOUN I-LF
( PUNCT B-O
ADCs PROPN B-AC
) PUNCT B-O
of ADP B-O
DM PROPN B-AC
, PUNCT B-O
protein NOUN B-O
, PUNCT B-O
lipid NOUN B-O
, PUNCT B-O
ash NOUN B-O
and CCONJ B-O
energy NOUN B-O
were AUX B-O
calculated VERB B-O
using VERB B-O
the DET B-O
following VERB B-O
equation NOUN B-O
[ X B-O
25 NUM B-O
] PUNCT B-O
: PUNCT B-O
ADCnutrientorenergy=[1−(Markerfeed×NutrientfaecesMarkerfaeces×Nutrientfeed)]×100(1 X B-O
) PUNCT B-O
ADCdry ADJ B-O
matter=[1−(MarkerfeedMarkerfaeces)]×100(2 X B-O
) PUNCT B-O
where SCONJ B-O
Markerfeed PROPN B-O
and CCONJ B-O
Markerfaeces NOUN B-O
are AUX B-O
the DET B-O
contents NOUN B-O
of ADP B-O
the DET B-O
marker NOUN B-O
( PUNCT B-O
% PUNCT B-O
dry ADJ B-LF
matter NOUN I-LF
) PUNCT B-O
in ADP B-O
the DET B-O
feed NOUN B-O
and CCONJ B-O
faeces NOUN B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
and CCONJ B-O
Nutrientfeed PROPN B-O
and CCONJ B-O
Nutrientfaeces PROPN B-O
are AUX B-O
the DET B-O
nutrient NOUN B-O
contents NOUN B-O
( PUNCT B-O
% PUNCT B-O
dry ADJ B-LF
matter NOUN I-LF
) PUNCT B-O
in ADP B-O
the DET B-O
feed NOUN B-O
and CCONJ B-O
faeces NOUN B-O
. PUNCT B-O

Excess ADJ B-LF
lung NOUN I-LF
weight NOUN I-LF
( PUNCT B-O
ELW PROPN B-AC
) PUNCT B-O
showed VERB B-O
highly ADV B-O
significant ADJ B-O
correlation NOUN B-O
with ADP B-O
parameters NOUN B-O
describing VERB B-O
inflation NOUN B-O
( PUNCT B-O
inflated VERB B-O
lung NOUN B-O
tissue NOUN B-O
[ X B-O
% X B-O
] X B-O
p NOUN B-O
= SYM B-O
0.0001 NUM B-O
r NOUN B-O
= SYM B-O
-0.65 NUM B-O
) PUNCT B-O
, PUNCT B-O
haemodynamics NOUN B-O
( PUNCT B-O
SOFA_cv NOUN B-O
mean NOUN B-O
p NOUN B-O
= SYM B-O
0.03 NUM B-O
r NOUN B-O
= SYM B-O
0.41 NUM B-O
) PUNCT B-O
and CCONJ B-O
applied VERB B-O
ventilation NOUN B-O
pressures NOUN B-O
( PUNCT B-O
PEEP PROPN B-AC
[ X B-O
mmHg X B-O
] X B-O
p NOUN B-O
= SYM B-O
0.05 NUM B-O
r NOUN B-O
= SYM B-O
0.37 NUM B-O
) PUNCT B-O
. PUNCT B-O

To PART B-O
do VERB B-O
so ADV B-O
we PRON B-O
apply VERB B-O
descriptive ADJ B-O
statistics NOUN B-O
and CCONJ B-O
conduct VERB B-O
logistic ADJ B-O
and CCONJ B-O
multinomial ADJ B-O
regressions NOUN B-O
using VERB B-O
data NOUN B-O
from ADP B-O
the DET B-O
Service PROPN B-LF
Provision PROPN I-LF
Assessment PROPN I-LF
( PUNCT B-O
SPA PROPN B-AC
) PUNCT B-O
of ADP B-O
the DET B-O
Demographic PROPN B-LF
and CCONJ I-LF
Health PROPN I-LF
Surveys PROPN I-LF
( PUNCT B-O
DHS PROPN B-AC
) PUNCT B-O
for ADP B-O
all DET B-O
health NOUN B-O
facilities NOUN B-O
in ADP B-O
Malawi PROPN B-O
in ADP B-O
2013/2014 NUM B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
CABG PROPN B-AC
, PUNCT B-O
coronary ADJ B-LF
artery NOUN I-LF
bypass NOUN I-LF
grift NOUN I-LF
; PUNCT B-O
PTCA PROPN B-AC
, PUNCT B-O
percutaneous ADJ B-LF
transluminal ADJ I-LF
coronary ADJ I-LF
angioplasty NOUN I-LF
; PUNCT B-O
ACE PROPN B-AC
: PUNCT B-O
Angiotensin NOUN B-LF
converting VERB I-LF
enzyme NOUN I-LF
. PUNCT B-O

Consignments NOUN B-O
with ADP B-O
one NUM B-O
or CCONJ B-O
more ADJ B-O
“ PUNCT B-O
POS PROPN B-AC
” PUNCT B-O
samples NOUN B-O
were AUX B-O
classified VERB B-O
as ADP B-O
OJD PROPN B-AC
“ PUNCT B-O
Positive ADJ B-LF
” PUNCT B-O
. PUNCT B-O

GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
RNAi PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
interference NOUN I-LF
; PUNCT B-O
TOR PROPN B-AC
, PUNCT B-O
Target NOUN B-LF
of ADP I-LF
Rapamycin PROPN I-LF
; PUNCT B-O
tub NOUN B-O
. PUNCT B-O

Gal4 NOUN B-O
, PUNCT B-O
tubulin NOUN B-O
. PUNCT B-O

Gal4 NOUN B-O
; PUNCT B-O
UAS PROPN B-AC
, PUNCT B-O
Upstream PROPN B-LF
activator NOUN I-LF
sequence NOUN I-LF
; PUNCT B-O
Yki PROPN B-AC
, PUNCT B-O
Yorkie PROPN B-LF
. PUNCT B-O

The DET B-O
Italian ADJ B-LF
Liver PROPN I-LF
Cancer PROPN I-LF
( PUNCT B-O
ITA.LI.CA PROPN B-AC
) PUNCT B-O
dataset NOUN B-O
, PUNCT B-O
including VERB B-O
more ADJ B-O
than ADP B-O
5,000 NUM B-O
Italian ADJ B-O
HCC PROPN B-AC
patients NOUN B-O
prospectively ADV B-O
enrolled VERB B-O
from ADP B-O
1 NUM B-O
January PROPN B-O
1987 NUM B-O
to ADP B-O
31 NUM B-O
March PROPN B-O
2012 NUM B-O
, PUNCT B-O
was AUX B-O
used VERB B-O
for ADP B-O
the DET B-O
training NOUN B-O
and CCONJ B-O
internal ADJ B-O
validation NOUN B-O
sets NOUN B-O
. PUNCT B-O

Schisandra PROPN B-LF
chinensis PROPN I-LF
( PUNCT B-O
SC PROPN B-AC
) PUNCT B-O
has VERB B-O
a DET B-O
long ADJ B-O
history NOUN B-O
as ADP B-O
a DET B-O
medicinal ADJ B-O
herb NOUN B-O
and CCONJ B-O
is AUX B-O
a DET B-O
traditional ADJ B-O
component NOUN B-O
in ADP B-O
oriental ADJ B-O
medicines NOUN B-O
[ PUNCT B-O
19,20 NUM B-O
] PUNCT B-O
. PUNCT B-O

Astrocytes NOUN B-LF
aged VERB I-LF
seven NUM I-LF
days NOUN I-LF
( PUNCT B-O
E7 PROPN B-AC
) PUNCT B-O
showed VERB B-O
increased VERB B-O
proliferation NOUN B-O
and CCONJ B-O
diminished ADJ B-O
differentiation NOUN B-O
, PUNCT B-O
while SCONJ B-O
21 NUM B-O
- PUNCT B-O
day NOUN B-O
- PUNCT B-O
old ADJ B-O
( PUNCT B-O
E21 PROPN B-AC
) PUNCT B-O
astrocytes NOUN B-O
depicted VERB B-O
reversed VERB B-O
effects NOUN B-O
. PUNCT B-O

ARE PROPN B-AC
, PUNCT B-O
antioxidant ADJ B-LF
response NOUN I-LF
element NOUN I-LF
; PUNCT B-O
IHC PROPN B-O
, PUNCT B-O
immunohistochemical NOUN B-O
; PUNCT B-O
MEF PROPN B-AC
, PUNCT B-O
mouse NOUN B-LF
embryonic ADJ I-LF
fibroblast NOUN I-LF
; PUNCT B-O
NRF2 PROPN B-AC
, PUNCT B-O
nuclear ADJ B-LF
factor NOUN I-LF
- PUNCT I-LF
erythroid NOUN I-LF
2 NUM I-LF
- PUNCT I-LF
like ADJ I-LF
2 NUM I-LF
; PUNCT B-O
PTCH1 PROPN B-AC
, PUNCT B-O
Patched VERB B-LF
1 NUM I-LF
Reviewer NOUN B-O
# NOUN B-O
3 NUM B-O
: PUNCT B-O
In ADP B-O
this DET B-O
randomized ADJ B-O
controlled VERB B-O
trial NOUN B-O
, PUNCT B-O
the DET B-O
Vienna PROPN B-LF
Prediction PROPN I-LF
Model PROPN I-LF
( PUNCT B-O
VPM PROPN B-AC
) PUNCT B-O
was AUX B-O
tested VERB B-O
to ADP B-O
determine VERB B-O
whether SCONJ B-O
implementing VERB B-O
the DET B-O
model NOUN B-O
would AUX B-O
reduce VERB B-O
recurrence NOUN B-O
risk NOUN B-O
. PUNCT B-O

883 NUM B-O
patients NOUN B-O
were AUX B-O
randomised VERB B-O
to ADP B-O
using VERB B-O
the DET B-O
VPM PROPN B-AC
compared VERB B-O
with ADP B-O
usual ADJ B-O
care NOUN B-O
. PUNCT B-O

While SCONJ B-O
various ADJ B-O
cytokines NOUN B-O
and CCONJ B-O
growth NOUN B-O
factors NOUN B-O
are AUX B-O
considered VERB B-O
to ADP B-O
contribute VERB B-O
to ADP B-O
skin NOUN B-O
fibroblast NOUN B-O
activation NOUN B-O
in ADP B-O
scleroderma NOUN B-O
, PUNCT B-O
transforming VERB B-LF
growth NOUN I-LF
factor NOUN I-LF
- PUNCT I-LF
β PUNCT I-LF
( PUNCT B-O
TGF-β PROPN B-AC
) PUNCT B-O
plays VERB B-O
an DET B-O
important ADJ B-O
role NOUN B-O
in ADP B-O
the DET B-O
fibrotic ADJ B-O
reaction NOUN B-O
of ADP B-O
scleroderma NOUN B-O
pathology NOUN B-O
[ X B-O
5 NUM B-O
, PUNCT B-O
6 NUM B-O
] PUNCT B-O
. PUNCT B-O

Additionally ADV B-O
, PUNCT B-O
the DET B-O
latest ADJ B-O
2020 NUM B-O
ESC PROPN B-O
Acute ADJ B-O
Coronary ADJ B-O
Syndromes PROPN B-O
( PUNCT B-O
ACS PROPN B-O
) PUNCT B-O
in ADP B-O
Patients NOUN B-O
Presenting VERB B-O
without ADP B-O
Persistent ADJ B-O
ST ADJ B-O
- PUNCT B-O
Segment PROPN B-O
Elevation PROPN B-O
( PUNCT B-O
Management NOUN B-O
of ADP B-O
) PUNCT B-O
Guidelines PROPN B-O
recommend VERB B-O
complete ADJ B-O
revascularization NOUN B-O
in ADP B-O
non ADJ B-O
- PUNCT B-O
ST ADJ B-O
- PUNCT B-O
elevation ADJ B-O
acute ADJ B-O
coronary ADJ B-O
syndrome NOUN B-O
( PUNCT B-O
NSTE PROPN B-O
- PUNCT B-O
ACS PROPN B-O
) PUNCT B-O
patients NOUN B-O
without ADP B-O
cardiogenic ADJ B-O
shock NOUN B-O
and CCONJ B-O
with ADP B-O
MV PROPN B-O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
CAD PROPN B-AC
) PUNCT B-O
but CCONJ B-O
offer VERB B-O
no DET B-O
recommendations NOUN B-O
for ADP B-O
patients NOUN B-O
with ADP B-O
severe ADJ B-O
LVSD NOUN B-O
[ PUNCT B-O
12 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
have AUX B-O
previously ADV B-O
described VERB B-O
the DET B-O
presence NOUN B-O
of ADP B-O
the DET B-O
complement NOUN B-O
- PUNCT B-O
regulating VERB B-O
protein NOUN B-O
salivary ADJ B-LF
scavenger NOUN I-LF
and CCONJ I-LF
agglutinin NOUN I-LF
( PUNCT B-O
SALSA PROPN B-AC
) PUNCT B-O
in ADP B-O
amniotic ADJ B-O
fluid NOUN B-O
. PUNCT B-O

Their PRON B-O
serum NOUN B-O
samples NOUN B-O
were AUX B-O
extracted VERB B-O
from ADP B-O
a DET B-O
population NOUN B-O
- PUNCT B-O
representative ADJ B-O
biobank NOUN B-O
, PUNCT B-O
the DET B-O
Finnish PROPN B-LF
Maternity PROPN I-LF
Cohort PROPN I-LF
( PUNCT B-O
FMC PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
18,21 NUM B-O
] PUNCT B-O
. PUNCT B-O

Previous ADJ B-O
studies NOUN B-O
of ADP B-O
ischemia NOUN B-LF
- ADJ I-LF
reperfusion NOUN I-LF
injury NOUN I-LF
( PUNCT B-O
IRI PROPN B-AC
) PUNCT B-O
in ADP B-O
hearts NOUN B-O
from ADP B-O
mice NOUN B-O
with ADP B-O
cardiac NOUN B-O
- ADJ B-O
restricted VERB B-O
overexpression NOUN B-O
of ADP B-O
CCN2 PROPN B-O
have AUX B-O
shown VERB B-O
that SCONJ B-O
CCN2 PROPN B-O
increases VERB B-O
tolerance NOUN B-O
towards ADP B-O
IRI PROPN B-AC
. PUNCT B-O

The DET B-O
objectives NOUN B-O
of ADP B-O
this DET B-O
study NOUN B-O
were AUX B-O
to PART B-O
investigate VERB B-O
to PART B-O
what DET B-O
extent NOUN B-O
post ADJ B-O
- ADJ B-O
ischemic ADJ B-O
administration NOUN B-O
of ADP B-O
recombinant ADJ B-O
human ADJ B-O
CCN2 PROPN B-O
( PUNCT B-O
rhCCN2 PROPN B-AC
) PUNCT B-O
would AUX B-O
limit VERB B-O
infarct ADJ B-O
size NOUN B-O
and CCONJ B-O
improve VERB B-O
functional ADJ B-O
recovery NOUN B-O
and CCONJ B-O
what DET B-O
signaling NOUN B-O
pathways NOUN B-O
are AUX B-O
involved VERB B-O
. PUNCT B-O

Type NOUN B-O
I NUM B-O
methanotrophs NOUN B-O
( PUNCT B-O
including VERB B-O
Methylococcus PROPN B-O
) PUNCT B-O
, PUNCT B-O
which PRON B-O
are AUX B-O
all PRON B-O
members NOUN B-O
of ADP B-O
the DET B-O
Gammaproteobacteria NOUN B-O
, PUNCT B-O
utilize VERB B-O
ribulose NOUN B-LF
monophosphate NOUN I-LF
( PUNCT B-O
RuMP PROPN B-AC
) PUNCT B-O
as ADP B-O
the DET B-O
primary ADJ B-O
pathway NOUN B-O
for ADP B-O
formaldehyde NOUN B-O
assimilation NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
those PRON B-O
of ADP B-O
type NOUN B-O
II NUM B-O
, PUNCT B-O
which PRON B-O
are AUX B-O
all PRON B-O
Alphaproteobacteria NOUN B-O
, PUNCT B-O
use VERB B-O
the DET B-O
serine ADJ B-O
pathway NOUN B-O
( PUNCT B-O
Hanson PROPN B-O
and CCONJ B-O
Hanson PROPN B-O
1996 NUM B-O
) PUNCT B-O
. PUNCT B-O

For ADP B-O
SNP PROPN B-AC
validation NOUN B-O
statistics NOUN B-O
using VERB B-O
a DET B-O
Markov PROPN B-O
chain NOUN B-O
method NOUN B-O
, PUNCT B-O
the DET B-O
selected VERB B-O
SNP PROPN B-AC
markers NOUN B-O
were AUX B-O
further ADV B-O
examined VERB B-O
by ADP B-O
testing VERB B-O
the DET B-O
deviation NOUN B-O
from ADP B-O
Hardy PROPN B-LF
Weinberg PROPN I-LF
equilibrium NOUN I-LF
( PUNCT B-O
HWE PROPN B-AC
) PUNCT B-O
for ADP B-O
each DET B-O
SNP PROPN B-AC
locus NOUN B-O
( PUNCT B-O
S62 PROPN B-O
Table NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
for ADP B-O
each DET B-O
breed NOUN B-O
population NOUN B-O
( PUNCT B-O
S63 PROPN B-O
Table NOUN B-O
) PUNCT B-O
. PUNCT B-O

Those DET B-O
individuals NOUN B-O
who PRON B-O
participated VERB B-O
in ADP B-O
an DET B-O
external ADJ B-LF
quality NOUN I-LF
assurance NOUN I-LF
( PUNCT B-O
EQA PROPN B-AC
) PUNCT B-O
program NOUN B-O
accounted VERB B-O
for ADP B-O
36(60 NUM B-O
% NOUN B-O
) PUNCT B-O
( PUNCT B-O
Table NOUN B-O
1 NUM B-O
) PUNCT B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
the DET B-O
Swedish ADJ B-O
study NOUN B-O
of ADP B-O
Rai PROPN B-O
et PROPN B-O
al.[11 X B-O
] X B-O
reported VERB B-O
a DET B-O
clear ADJ B-O
increase NOUN B-O
in ADP B-O
prevalence NOUN B-O
in ADP B-O
the DET B-O
most ADV B-O
deprived ADJ B-O
backgrounds NOUN B-O
even ADV B-O
after ADP B-O
taking VERB B-O
into ADP B-O
account NOUN B-O
other ADJ B-O
associated VERB B-O
factors NOUN B-O
and CCONJ B-O
for ADP B-O
all DET B-O
cases NOUN B-O
of ADP B-O
ASD PROPN B-AC
studied VERB B-O
i.e. X B-O
with ADP B-O
or CCONJ B-O
without ADP B-O
associated VERB B-O
intellectual ADJ B-LF
disability NOUN I-LF
( PUNCT B-O
ID PROPN B-AC
) PUNCT B-O
. PUNCT B-O

A DET B-O
comparison NOUN B-O
of ADP B-O
comorbidities NOUN B-O
recorded VERB B-O
through ADP B-O
HES PROPN B-AC
with ADP B-O
those PRON B-O
from ADP B-O
primary ADJ B-O
care NOUN B-O
records NOUN B-O
( PUNCT B-O
clinical ADJ B-LF
practice NOUN I-LF
research NOUN I-LF
database NOUN I-LF
, PUNCT B-O
CPRD PROPN B-AC
) PUNCT B-O
found VERB B-O
that SCONJ B-O
CPRD PROPN B-AC
recorded VERB B-O
more ADJ B-O
comorbidity NOUN B-O
than ADP B-O
HES PROPN B-AC
, PUNCT B-O
but CCONJ B-O
this PRON B-O
did AUX B-O
not PART B-O
adversely ADV B-O
affect VERB B-O
their PRON B-O
models NOUN B-O
of ADP B-O
mortality NOUN B-O
risk NOUN B-O
after ADP B-O
gastrointestinal ADJ B-O
bleeding NOUN B-O
or CCONJ B-O
diabetes NOUN B-O
[ PUNCT B-O
24 NUM B-O
] PUNCT B-O
. PUNCT B-O

In SCONJ B-O
order NOUN B-O
to PART B-O
examine VERB B-O
whether SCONJ B-O
ID PROPN B-AC
is AUX B-O
related VERB B-O
with ADP B-O
children NOUN B-O
with ADP B-O
hypothyroidism NOUN B-O
or CCONJ B-O
with ADP B-O
low ADJ B-O
income NOUN B-O
, PUNCT B-O
multivariable ADJ B-O
analyses NOUN B-O
were AUX B-O
performed VERB B-O
using VERB B-O
Cox PROPN B-O
proportional ADJ B-O
hazards NOUN B-O
models NOUN B-O
to PART B-O
calculate VERB B-O
adjusted VERB B-O
hazard NOUN B-LF
ratios NOUN I-LF
( PUNCT B-O
HRs PROPN B-AC
) PUNCT B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
intervals NOUN I-LF
[ PUNCT B-O
CIs PROPN B-AC
] PUNCT B-O
) PUNCT B-O
as ADP B-O
an DET B-O
estimate NOUN B-O
of ADP B-O
the DET B-O
relative ADJ B-O
rate NOUN B-O
of ADP B-O
ID PROPN B-AC
. PUNCT B-O

The DET B-O
proportionality NOUN B-O
assumption NOUN B-O
was AUX B-O
tested VERB B-O
by ADP B-O
plotting VERB B-O
Schoenfeld PROPN B-O
- PUNCT B-O
like ADJ B-O
residuals NOUN B-O
. PUNCT B-O

This DET B-O
pathway NOUN B-O
directly ADV B-O
controls VERB B-O
the DET B-O
expression NOUN B-O
of ADP B-O
many ADJ B-O
cell NOUN B-O
- PUNCT B-O
cycle NOUN B-O
genes NOUN B-O
and CCONJ B-O
plays VERB B-O
a DET B-O
key ADJ B-O
role NOUN B-O
in ADP B-O
embryonic ADJ B-LF
stem NOUN I-LF
cell NOUN I-LF
( PUNCT B-O
ESC PROPN B-AC
) PUNCT B-O
self NOUN B-O
- PUNCT B-O
renewal NOUN B-O
[ PUNCT B-O
37–39,54,55 NUM B-O
] PUNCT B-O
. PUNCT B-O

Data NOUN B-O
are AUX B-O
presented VERB B-O
as ADP B-O
mean ADJ B-LF
fluorescence NOUN I-LF
intensity NOUN I-LF
( PUNCT B-O
MFI PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
MFI PROPN B-AC
was AUX B-O
determined VERB B-O
by ADP B-O
FlowJo PROPN B-O
Software PROPN B-O
( PUNCT B-O
TreeStar PROPN B-O
, PUNCT B-O
Ashland PROPN B-O
, PUNCT B-O
OR PROPN B-O
, PUNCT B-O
USA PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
line NOUN B-O
in ADP B-O
the DET B-O
middle NOUN B-O
represents VERB B-O
the DET B-O
median ADJ B-O
value NOUN B-O
. PUNCT B-O

One NUM B-O
such ADJ B-O
insecticide NOUN B-O
is AUX B-O
pyriproxyfen NOUN B-LF
( PUNCT B-O
PPF PROPN B-AC
) PUNCT B-O
, PUNCT B-O
an DET B-O
insect NOUN B-O
juvenile ADJ B-O
hormone NOUN B-O
analogue NOUN B-O
that PRON B-O
kills VERB B-O
mosquito NOUN B-O
juveniles NOUN B-O
at ADP B-O
minute ADJ B-O
doses NOUN B-O
and CCONJ B-O
can AUX B-O
safely ADV B-O
be AUX B-O
used VERB B-O
even ADV B-O
in ADP B-O
drinking NOUN B-O
water NOUN B-O
[ PUNCT B-O
3,27,28 NUM B-O
] PUNCT B-O
. PUNCT B-O

Of ADP B-O
the DET B-O
22 NUM B-O
studies NOUN B-O
providing VERB B-O
results NOUN B-O
from ADP B-O
human ADJ B-LF
immunodeficiency NOUN I-LF
virus NOUN I-LF
( PUNCT B-O
HIV)-testing PROPN B-AC
, PUNCT B-O
12 NUM B-O
( PUNCT B-O
55 NUM B-O
% PUNCT B-O
) PUNCT B-O
reported VERB B-O
HIV PROPN B-AC
prevalence NOUN B-O
greater ADJ B-O
than ADP B-O
50%[39,40,42,43,45–49,55,59 NUM B-O
] PUNCT B-O
. PUNCT B-O

To PART B-O
investigate VERB B-O
whether SCONJ B-O
spz5 PROPN B-O
has VERB B-O
neurotrophic ADJ B-O
function NOUN B-O
we PRON B-O
first ADV B-O
visualised VERB B-O
its PRON B-O
expression NOUN B-O
pattern NOUN B-O
. PUNCT B-O

spz5 PROPN B-O
is AUX B-O
expressed VERB B-O
at ADP B-O
the DET B-O
embryonic ADJ B-O
CNS PROPN B-AC
midline NOUN B-O
( PUNCT B-O
Figure PROPN B-O
8C NUM B-O
) PUNCT B-O
, PUNCT B-O
in ADP B-O
muscles NOUN B-O
( PUNCT B-O
Figure PROPN B-O
9A NUM B-O
) PUNCT B-O
, PUNCT B-O
in ADP B-O
the DET B-O
epidermis NOUN B-O
( PUNCT B-O
unpublished ADJ B-O
data NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
in ADP B-O
the DET B-O
embryonic ADJ B-O
head NOUN B-O
peripheral ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
( PUNCT B-O
PNS PROPN B-AC
) PUNCT B-O
( PUNCT B-O
unpublished ADJ B-O
data NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
drug NOUN B-O
was AUX B-O
applied VERB B-O
to ADP B-O
the DET B-O
skin NOUN B-O
daily ADV B-O
for ADP B-O
5 NUM B-O
days NOUN B-LF
( PUNCT B-O
5 NUM B-O
d PROPN B-AC
) PUNCT B-O
or CCONJ B-O
for ADP B-O
12 NUM B-O
days NOUN B-LF
( PUNCT B-O
1 NUM B-O
, PUNCT B-O
2 NUM B-O
, PUNCT B-O
3 NUM B-O
, PUNCT B-O
4 NUM B-O
, PUNCT B-O
5 NUM B-O
, PUNCT B-O
8 NUM B-O
, PUNCT B-O
9 NUM B-O
, PUNCT B-O
10 NUM B-O
, PUNCT B-O
11 NUM B-O
, PUNCT B-O
12th ADJ B-O
day NOUN B-LF
) PUNCT B-O
( PUNCT B-O
12d NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
routing NOUN B-O
of ADP B-O
DNA NOUN B-O
through ADP B-O
the DET B-O
double ADJ B-O
hexamers NOUN B-O
is AUX B-O
unclear ADJ B-O
, PUNCT B-O
and CCONJ B-O
none NOUN B-O
of ADP B-O
the DET B-O
high ADJ B-O
- PUNCT B-O
resolution NOUN B-O
structures NOUN B-O
of ADP B-O
T-ag PROPN B-AC
to ADP B-O
date NOUN B-O
have AUX B-O
included VERB B-O
DNA NOUN B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
the DET B-O
recent ADJ B-O
structure NOUN B-O
of ADP B-O
the DET B-O
BPV PROPN B-AC
initiator NOUN B-O
E1 NOUN B-O
helicase NOUN B-O
domain NOUN B-O
shows VERB B-O
that SCONJ B-O
E1 NOUN B-O
forms VERB B-O
a DET B-O
hexameric ADJ B-O
ring NOUN B-O
which PRON B-O
contains VERB B-O
single ADJ B-LF
- PUNCT I-LF
stranded ADJ I-LF
DNA NOUN I-LF
( PUNCT B-O
ssDNA PROPN B-AC
) PUNCT B-O
within ADP B-O
its PRON B-O
central ADJ B-O
channel NOUN B-O
[ PUNCT B-O
20 NUM B-O
] PUNCT B-O
. PUNCT B-O

“ PUNCT B-O
Rabbit PROPN B-O
ear NOUN B-O
” PUNCT B-O
protrusions NOUN B-O
emanating VERB B-O
from ADP B-O
the DET B-O
dodecameric ADJ B-O
T PROPN B-AC
complex NOUN B-O
have AUX B-O
been AUX B-O
observed VERB B-O
on ADP B-O
electron NOUN B-O
microscopy NOUN B-O
, PUNCT B-O
and CCONJ B-O
these DET B-O
protrusions NOUN B-O
have AUX B-O
been AUX B-O
attributed VERB B-O
to ADP B-O
-agssDNA PROPN B-AC
coated VERB B-O
by ADP B-O
RPA PROPN B-AC
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
tested VERB B-O
nonactivated ADJ B-O
and CCONJ B-O
PHA PROPN B-O
- PUNCT B-O
activated VERB B-O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT B-O
PBMCs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
purified VERB B-O
cell NOUN B-O
subsets NOUN B-O
, PUNCT B-O
including VERB B-O
CD14 NOUN B-O
+ NOUN B-O
monocytes NOUN B-O
, PUNCT B-O
activated VERB B-O
CD4 NOUN B-O
+ NOUN B-O
T NOUN B-O
cells NOUN B-O
, PUNCT B-O
immature ADJ B-O
and CCONJ B-O
mature ADJ B-O
monocyte NOUN B-O
- PUNCT B-O
derived VERB B-O
dendritic ADJ B-LF
cells NOUN I-LF
( PUNCT B-O
DCs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

LASSO PROPN B-AC
= PUNCT B-O
least ADJ B-LF
absolute ADJ I-LF
shrinkage NOUN I-LF
and CCONJ I-LF
selection NOUN I-LF
operator NOUN I-LF
. PUNCT B-O

Parent(s)/legal NOUN B-O
authorized ADJ B-O
representatives NOUN B-O
also ADV B-O
provided VERB B-O
current ADJ B-O
inhaled VERB B-LF
corticosteroid NOUN I-LF
( PUNCT B-O
ICS PROPN B-AC
) PUNCT B-O
controller NOUN B-O
medication NOUN B-O
( PUNCT B-O
Asmanex PROPN B-O
® PUNCT B-O
, PUNCT B-O
Flovent PROPN B-O
® PUNCT B-O
, PUNCT B-O
Qvar PROPN B-O
® PUNCT B-O
, PUNCT B-O
Pulmicort PROPN B-O
® PUNCT B-O
, PUNCT B-O
Advair PROPN B-O
® PUNCT B-O
, PUNCT B-O
Dulera PROPN B-O
® PUNCT B-O
, PUNCT B-O
Symbicort PROPN B-O
® PUNCT B-O
, PUNCT B-O
etc X B-O
. PUNCT B-O

) PUNCT B-O
. PUNCT B-O

For ADP B-O
transmission NOUN B-LF
electron NOUN I-LF
microscopy NOUN I-LF
( PUNCT B-O
TEM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
specimens NOUN B-O
were AUX B-O
then ADV B-O
washed VERB B-O
3×20 NUM B-O
min NOUN B-O
in ADP B-O
the DET B-O
same ADJ B-O
buffer NOUN B-O
as SCONJ B-O
used VERB B-O
for ADP B-O
fixation NOUN B-O
, PUNCT B-O
and CCONJ B-O
post VERB B-O
- VERB B-O
fixed VERB B-O
in ADP B-O
1–2 NUM B-O
% NOUN B-O
osmium NOUN B-O
tetroxide NOUN B-O
( PUNCT B-O
OsO4 NOUN B-O
) PUNCT B-O
in ADP B-O
the DET B-O
same ADJ B-O
buffer NOUN B-O
for ADP B-O
1–3 NUM B-O
h. NOUN B-O
According VERB B-O
to ADP B-O
projection NOUN B-O
of ADP B-O
Central PROPN B-LF
Statistics PROPN I-LF
Agency PROPN I-LF
( PUNCT B-O
CSA PROPN B-AC
) PUNCT B-O
of ADP B-O
Ethiopia PROPN B-O
, PUNCT B-O
in ADP B-O
the DET B-O
year NOUN B-O
2014 NUM B-O
its PRON B-O
population NOUN B-O
was AUX B-O
about ADP B-O
3.2 NUM B-O
million NUM B-O
[ PUNCT B-O
17 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
Major ADJ B-O
Adverse PROPN B-O
Cardiovascular PROPN B-O
Events PROPN B-O
calculator NOUN B-O
( PUNCT B-O
CRCRTR-MACE PROPN B-AC
) PUNCT B-O
estimates VERB B-O
the DET B-O
burden NOUN B-O
of ADP B-O
cardiovascular ADJ B-O
risk NOUN B-O
in ADP B-O
renal ADJ B-LF
transplant NOUN I-LF
recipients NOUN I-LF
( PUNCT B-O
RTR PROPN B-AC
) PUNCT B-O
. NOUN B-O
Our PRON B-O
recent ADJ B-O
study NOUN B-O
of ADP B-O
95 NUM B-O
RTR PROPN B-AC
reported VERB B-O
the DET B-O
7 NUM B-O
- PUNCT B-O
year NOUN B-O
median ADJ B-O
risk NOUN B-O
of ADP B-O
cardiovascular ADJ B-O
events NOUN B-O
( PUNCT B-O
CVE PROPN B-O
) PUNCT B-O
to ADP B-O
be AUX B-O
9.97 NUM B-O
% NOUN B-O
, PUNCT B-O
ranging VERB B-O
from ADP B-O
1.93 NUM B-O
to ADP B-O
84.27 NUM B-O
% NOUN B-O
. NOUN B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
DHQ PROPN B-AC
, PUNCT B-O
Diet PROPN B-LF
History PROPN I-LF
Questionnaire PROPN I-LF
. PUNCT B-O

The DET B-O
main ADJ B-O
outcome NOUN B-O
variable NOUN B-O
was AUX B-O
the DET B-O
nutritional ADJ B-O
status NOUN B-O
of ADP B-O
reproductive ADJ B-O
age NOUN B-O
women NOUN B-O
, PUNCT B-O
measured VERB B-O
using VERB B-O
the DET B-O
WHO PROPN B-AC
adult NOUN B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
classification NOUN B-O
[ PUNCT B-O
13 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
used VERB B-O
by ADP B-O
the DET B-O
Tanzanian PROPN B-O
National PROPN B-O
Bureau PROPN B-O
of ADP B-O
Statistics PROPN B-O
and CCONJ B-O
ICF PROPN B-AC
International PROPN B-O
[ PUNCT B-O
24 NUM B-O
] PUNCT B-O
. PUNCT B-O

Using VERB B-O
rat ADJ B-O
insulinoma NOUN B-O
INS-1 NOUN B-O
832/3 NUM B-O
cells NOUN B-O
engineered VERB B-O
by ADP B-O
clustered VERB B-LF
regularly ADV I-LF
interspaced VERB I-LF
short ADJ I-LF
palindromic ADJ I-LF
repeat NOUN I-LF
( PUNCT B-O
- PUNCT I-LF
CRISPR)/CRISPR PROPN B-AC
associated VERB I-LF
9 NUM I-LF
( PUNCT B-O
Cas9 PROPN B-AC
) PUNCT B-O
to PART B-O
delete VERB B-O
endogenous ADJ B-O
GLP-1R PROPN B-AC
[ X B-O
40 X B-O
] X B-O
stably ADV B-O
expressing VERB B-O
human ADJ B-O
SNAP PROPN B-O
- PUNCT B-O
GLP-1R PROPN B-AC
( PUNCT B-O
INS-1 NOUN B-O
832/3 NUM B-O
GLP-1R−/− PROPN B-AC
SNAP PROPN B-O
- PUNCT B-O
GLP-1R PROPN B-AC
cells NOUN B-O
) PUNCT B-O
, PUNCT B-O
we PRON B-O
detected VERB B-O
a DET B-O
rapid ADJ B-O
increase NOUN B-O
in ADP B-O
TR PROPN B-AC
-FRET PROPN B-AC
with ADP B-O
exendin-4 NOUN B-O
, PUNCT B-O
which PRON B-O
reached VERB B-O
a DET B-O
maximum NOUN B-O
within ADP B-O
10 NUM B-O
min NOUN B-O
( PUNCT B-O
Fig NOUN B-O
1D NUM B-O
) PUNCT B-O
. PUNCT B-O

IRR PROPN B-AC
, PUNCT B-O
incidence NOUN B-LF
rate NOUN I-LF
ratio NOUN I-LF
To PART B-O
cytologically ADV B-O
characterize VERB B-O
the DET B-O
genetic ADJ B-O
constitution NOUN B-O
of ADP B-O
5113 NUM B-O
, PUNCT B-O
root NOUN B-O
cells NOUN B-O
and CCONJ B-O
pollen NOUN B-LF
mother NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
PMCs PROPN B-AC
) PUNCT B-O
were AUX B-O
used VERB B-O
( PUNCT B-O
Fig NUM B-O
1 NUM B-O
and CCONJ B-O
Table PROPN B-O
1 NUM B-O
) PUNCT B-O
. PUNCT B-O

Two NUM B-O
tissue NOUN B-O
- PUNCT B-O
specific ADJ B-O
DNase NOUN B-LF
l NOUN I-LF
hypersensitive ADJ I-LF
sites NOUN I-LF
( PUNCT B-O
DHS PROPN B-AC
) PUNCT B-O
in ADP B-O
this DET B-O
part NOUN B-O
of ADP B-O
the DET B-O
locus NOUN B-O
correspond VERB B-O
to ADP B-O
a DET B-O
promoter NOUN B-O
associated VERB B-O
with ADP B-O
DQ52 PROPN B-O
and CCONJ B-O
the DET B-O
intronic ADJ B-O
enhancer NOUN B-O
Eμ PROPN B-O
. PUNCT B-O

A DET B-O
cluster NOUN B-O
of ADP B-O
three NUM B-O
DHSs PROPN B-AC
was AUX B-O
recently ADV B-O
identified VERB B-O
just ADV B-O
5′ NUM B-O
of ADP B-O
DFL16.1 NUM B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
to PART B-O
diabetes NOUN B-LF
mellitus NOUN I-LF
( PUNCT B-O
DM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
established VERB B-O
as ADP B-O
one NUM B-O
of ADP B-O
the DET B-O
most ADV B-O
significant ADJ B-O
risk NOUN B-O
factors NOUN B-O
of ADP B-O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
CAD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
prediabetic ADJ B-O
conditions NOUN B-O
such ADJ B-O
as ADP B-O
impaired ADJ B-LF
glucose NOUN I-LF
tolerance NOUN I-LF
( PUNCT B-O
IGT PROPN B-AC
) PUNCT B-O
have AUX B-O
been AUX B-O
also ADV B-O
reported VERB B-O
to PART B-O
increase VERB B-O
the DET B-O
risk NOUN B-O
of ADP B-O
cardiovascular ADJ B-O
events NOUN B-O
and CCONJ B-O
affect VERB B-O
mortality NOUN B-O
rates NOUN B-O
[ PUNCT B-O
1 NUM B-O
, PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

GLM PROPN B-O
, PUNCT B-O
generalized ADJ B-O
linear ADJ B-O
model NOUN B-O
; PUNCT B-O
HCV PROPN B-AC
, PUNCT B-O
hepatitis NOUN B-LF
C PROPN I-LF
virus NOUN I-LF
; PUNCT B-O
HR PROPN B-AC
, PUNCT B-O
hazard NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
ITT PROPN B-AC
, PUNCT B-O
intention NOUN B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
treat VERB I-LF
; PUNCT B-O
OR PROPN B-AC
, PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
PP NOUN B-O
, PUNCT B-O
per ADP B-O
protocol NOUN B-O
; PUNCT B-O
SAE NOUN B-O
, PUNCT B-O
severe ADJ B-O
adverse ADJ B-O
event NOUN B-O
; PUNCT B-O
SVR PROPN B-AC
, PUNCT B-O
sustained ADJ B-LF
virologic ADJ I-LF
response NOUN I-LF
. PUNCT B-O

AC PROPN B-AC
, PUNCT B-O
adenylate NOUN B-LF
cyclase NOUN I-LF
catalytic ADJ I-LF
domain NOUN I-LF
; PUNCT B-O
CaM PROPN B-AC
, PUNCT B-O
calmodulin NOUN B-LF
. PUNCT B-O

ASE PROPN B-AC
, PUNCT B-O
allele NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
expression NOUN I-LF
; PUNCT B-O
BDNF PROPN B-AC
, PUNCT B-O
brain NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
neurotrophic ADJ I-LF
factor NOUN I-LF
; PUNCT B-O
F1 PROPN B-AC
, PUNCT B-O
first ADJ B-LF
- PUNCT I-LF
generation NOUN I-LF
; PUNCT B-O
OF PROPN B-AC
, PUNCT B-O
owl NOUN B-LF
finch NOUN I-LF
; PUNCT B-O
OZ PROPN B-AC
, PUNCT B-O
F1 PROPN B-AC
hybrid ADJ B-O
offspring NOUN B-O
between ADP B-O
OF PROPN B-AC
♀ PUNCT B-O
and CCONJ B-O
ZF PROPN B-AC
♂ PUNCT B-O
; PUNCT B-O
RA PROPN B-AC
, PUNCT B-O
robust ADJ B-LF
nucleus NOUN I-LF
of ADP I-LF
the DET I-LF
arcopallium NOUN I-LF
; PUNCT B-O
RPKM PROPN B-AC
, PUNCT B-O
reads NOUN B-LF
per ADP I-LF
kilobase NOUN I-LF
of ADP I-LF
transcript NOUN I-LF
per ADP I-LF
million NUM I-LF
reads NOUN I-LF
mapped VERB I-LF
; PUNCT B-O
ZF PROPN B-AC
, PUNCT B-O
zebra NOUN B-LF
finch NOUN I-LF
; PUNCT B-O
ZO PROPN B-AC
, PUNCT B-O
F1 PROPN B-AC
hybrid ADJ B-O
offspring NOUN B-O
between ADP B-O
ZF PROPN B-AC
♀ PUNCT B-O
and CCONJ B-O
OF PROPN B-AC
♂ PUNCT B-O
. PUNCT B-O

Recently ADV B-O
, PUNCT B-O
data NOUN B-O
from ADP B-O
the DET B-O
British PROPN B-O
Cardiac PROPN B-O
Intervention PROPN B-O
Society PROPN B-O
( PUNCT B-O
BCIS PROPN B-O
) PUNCT B-O
PCI PROPN B-AC
database NOUN B-O
[ X B-O
9 NUM B-O
] X B-O
and CCONJ B-O
Korea PROPN B-O
Acute PROPN B-O
Myocardial PROPN B-O
Infarction PROPN B-O
Registry PROPN B-O
[ X B-O
10 NUM B-O
, PUNCT B-O
11 NUM B-O
] X B-O
showed VERB B-O
significantly ADV B-O
lower ADJ B-O
cumulative ADJ B-O
mortality NOUN B-O
rates NOUN B-O
in ADP B-O
patients NOUN B-O
who PRON B-O
underwent VERB B-O
multivessel NOUN B-O
( PUNCT B-O
MV)-PCI NOUN B-O
than ADP B-O
in ADP B-O
those PRON B-O
who PRON B-O
underwent VERB B-O
infarct NOUN B-LF
- PUNCT I-LF
related VERB I-LF
artery NOUN I-LF
( PUNCT B-O
IRA)-only PROPN B-AC
PCI PROPN B-AC
, PUNCT B-O
demonstrating VERB B-O
that SCONJ B-O
LVSD PROPN B-O
is AUX B-O
a DET B-O
strong ADJ B-O
predictor NOUN B-O
of ADP B-O
all DET B-O
- PUNCT B-O
cause NOUN B-O
mortality NOUN B-O
. PUNCT B-O

Phosphoglycerate NOUN B-LF
kinase NOUN I-LF
( PUNCT B-O
PGK1 PROPN B-AC
) PUNCT B-O
catalyzes VERB B-O
the DET B-O
reversible ADJ B-O
phosphotransfer NOUN B-O
reaction NOUN B-O
from ADP B-O
1 NUM B-LF
, PUNCT I-LF
3 NUM I-LF
- PUNCT I-LF
bisphosphoglycerate NOUN I-LF
( PUNCT B-O
1,3-BPG PROPN B-AC
) PUNCT B-O
to PART B-O
ADP PROPN B-O
to PART B-O
form VERB B-O
3 NUM B-LF
- PUNCT I-LF
phosphoglycerate NOUN I-LF
( PUNCT B-O
3 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
ATP NOUN B-O
. PUNCT B-O

By ADP B-O
controlling VERB B-O
ATP NOUN B-O
and CCONJ B-O
-PG3 PROPN B-AC
levels NOUN B-O
, PUNCT B-O
-PGPGK1 PROPN B-AC
plays VERB B-O
an DET B-O
important ADJ B-O
role NOUN B-O
in ADP B-O
coordinating VERB B-O
energy NOUN B-O
production NOUN B-O
with ADP B-O
biosynthesis NOUN B-O
and CCONJ B-O
redox NOUN B-O
balance NOUN B-O
. PUNCT B-O

CeMM PROPN B-AC
, PUNCT B-O
C. PROPN B-O
elegans PROPN B-O
maintenance NOUN B-O
medium NOUN B-O
; PUNCT B-O
hlh-30 PROPN B-AC
, PUNCT B-O
basic ADJ B-LF
helix NOUN I-LF
– PUNCT I-LF
loop NOUN I-LF
– PUNCT I-LF
helix NOUN I-LF
transcription NOUN I-LF
factor NOUN I-LF
30 NUM I-LF
; PUNCT B-O
hlh-30(lf PROPN B-AC
) PUNCT B-O
, PUNCT B-O
loss NOUN B-O
- PUNCT B-O
of ADP B-O
- PUNCT B-O
function NOUN B-O
tm1978 PROPN B-AC
mutation NOUN B-O
hlh-30 PROPN B-AC
; PUNCT B-O
nhr-31 NOUN B-O
, PUNCT B-O
nuclear ADJ B-O
hormone NOUN B-O
receptor NOUN B-O
31 NUM B-O
; PUNCT B-O
nhr-31(oe NOUN B-O
) PUNCT B-O
, PUNCT B-O
overexpressed VERB B-O
nhr-31 NOUN B-O
; PUNCT B-O
SEM PROPN B-AC
, PUNCT B-O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
. PUNCT B-O

Nucleotide NOUN B-LF
- NOUN I-LF
binding VERB I-LF
leucine NOUN I-LF
- NOUN I-LF
rich ADJ I-LF
repeat NOUN I-LF
receptors NOUN I-LF
( PUNCT B-O
NLRs PROPN B-AC
) PUNCT B-O
are AUX B-O
key ADJ B-O
players NOUN B-O
in ADP B-O
this DET B-O
process NOUN B-O
and CCONJ B-O
perceive VERB B-O
the DET B-O
occurrence NOUN B-O
of ADP B-O
nonself NOUN B-O
- NOUN B-O
activities NOUN B-O
or CCONJ B-O
foreign ADJ B-O
molecules NOUN B-O
. PUNCT B-O

All DET B-O
imaging NOUN B-O
experiments NOUN B-O
with ADP B-O
the DET B-O
exception NOUN B-O
of ADP B-O
those PRON B-O
depicted VERB B-O
in ADP B-O
Fig NOUN B-O
1B–1E NUM B-O
and CCONJ B-O
Fig NOUN B-O
B NOUN B-O
in ADP B-O
S1 NOUN B-O
Fig NOUN B-O
were AUX B-O
performed VERB B-O
at ADP B-O
30 NUM B-O
° NOUN B-O
C NOUN B-O
on ADP B-O
a DET B-O
Nikon PROPN B-O
Eclipse PROPN B-O
Ti PROPN B-O
inverted ADJ B-O
microscope NOUN B-O
equipped VERB B-O
with ADP B-O
a DET B-O
motorized VERB B-O
laser NOUN B-O
total ADJ B-LF
internal ADJ I-LF
reflection NOUN I-LF
fluorescence NOUN I-LF
( PUNCT B-O
TIRF PROPN B-AC
) PUNCT B-O
illumination NOUN B-O
unit NOUN B-O
, PUNCT B-O
a DET B-O
Borealis PROPN B-O
beam NOUN B-O
conditioning NOUN B-O
unit NOUN B-O
( PUNCT B-O
Andor PROPN B-O
) PUNCT B-O
, PUNCT B-O
a DET B-O
CSU PROPN B-O
- PUNCT B-O
W1 PROPN B-O
Yokugawa PROPN B-O
spinning VERB B-O
disk NOUN B-O
( PUNCT B-O
Andor PROPN B-O
; PUNCT B-O
Belfast PROPN B-O
, PUNCT B-O
Northern PROPN B-O
Ireland PROPN B-O
) PUNCT B-O
, PUNCT B-O
a DET B-O
60X PROPN B-O
PlanApo PROPN B-O
TIRF PROPN B-AC
1.49 NUM B-O
numerical ADJ B-LF
aperture NOUN I-LF
( PUNCT B-O
NA PROPN B-AC
) PUNCT B-O
objective NOUN B-O
( PUNCT B-O
Nikon PROPN B-O
; PUNCT B-O
Toyko PROPN B-O
, PUNCT B-O
Japan PROPN B-O
) PUNCT B-O
, PUNCT B-O
an DET B-O
iXon PROPN B-O
Ultra PROPN B-O
EMCCD PROPN B-O
camera NOUN B-O
( PUNCT B-O
Andor PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
a DET B-O
laser NOUN B-O
merge NOUN B-O
module NOUN B-O
( PUNCT B-O
LMM5 PROPN B-O
, PUNCT B-O
Spectral PROPN B-O
Applied PROPN B-O
Research PROPN B-O
; PUNCT B-O
Exton PROPN B-O
, PUNCT B-O
PA PROPN B-O
) PUNCT B-O
equipped VERB B-O
with ADP B-O
405 NUM B-O
, PUNCT B-O
440 NUM B-O
, PUNCT B-O
488 NUM B-O
, PUNCT B-O
and CCONJ B-O
561 NUM B-O
- PUNCT B-O
nm NOUN B-O
laser NOUN B-O
lines NOUN B-O
. PUNCT B-O

Four NUM B-O
irrigation NOUN B-O
systems NOUN B-O
were AUX B-O
examined VERB B-O
in ADP B-O
this DET B-O
study NOUN B-O
: PUNCT B-O
furrow NOUN B-LF
irrigation NOUN I-LF
( PUNCT B-O
FI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
micro NOUN B-LF
- NOUN I-LF
sprinkler NOUN I-LF
irrigation NOUN I-LF
( PUNCT B-O
MS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
plastic NOUN B-O
film NOUN B-O
mulching NOUN B-O
( PUNCT B-O
PF PROPN B-AC
) PUNCT B-O
and CCONJ B-O
plastic NOUN B-O
film NOUN B-O
mulching NOUN B-O
combined VERB B-O
with ADP B-O
micro NOUN B-LF
- NOUN I-LF
sprinkler NOUN I-LF
irrigation NOUN I-LF
( PUNCT B-O
PF+MS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Of ADP B-O
these PRON B-O
, PUNCT B-O
FI PROPN B-AC
is AUX B-O
the DET B-O
local ADJ B-O
irrigation NOUN B-O
method NOUN B-O
widely ADV B-O
used VERB B-O
by ADP B-O
the DET B-O
local ADJ B-O
farmers NOUN B-O
and CCONJ B-O
thus ADV B-O
we PRON B-O
treated VERB B-O
FI PROPN B-AC
as ADP B-O
the DET B-O
control NOUN B-O
. PUNCT B-O

ADC PROPN B-AC
, PUNCT B-O
Apparent ADJ B-LF
Diffusion NOUN I-LF
Coefficient PROPN I-LF
; PUNCT B-O
IPca PROPN B-AC
, PUNCT B-O
insignificant ADJ B-LF
prostate NOUN I-LF
cancer NOUN I-LF
; PUNCT B-O
CSPca PROPN B-AC
, PUNCT B-O
clinically ADV B-LF
significant ADJ I-LF
prostate NOUN I-LF
cancer NOUN I-LF
. PUNCT B-O

We PRON B-O
investigated VERB B-O
557 NUM B-O
women NOUN B-O
, PUNCT B-O
recruited VERB B-O
between ADP B-O
2009 NUM B-O
and CCONJ B-O
2014 NUM B-O
from ADP B-O
the DET B-O
UK PROPN B-LF
Pregnancies PROPN I-LF
Better PROPN I-LF
Eating PROPN I-LF
and CCONJ I-LF
Activity PROPN I-LF
Trial PROPN I-LF
( PUNCT B-O
UPBEAT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
randomised ADJ B-LF
controlled VERB I-LF
trial NOUN I-LF
( PUNCT B-O
RCT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
of ADP B-O
a DET B-O
lifestyle NOUN B-O
intervention NOUN B-O
( PUNCT B-O
low ADJ B-O
glycaemic ADJ B-LF
index NOUN I-LF
( PUNCT B-O
GI PROPN B-AC
) PUNCT B-O
diet NOUN B-O
plus CCONJ B-O
physical ADJ B-O
activity NOUN B-O
) PUNCT B-O
in ADP B-O
pregnant ADJ B-O
women NOUN B-O
with ADP B-O
obesity NOUN B-O
( PUNCT B-O
294 NUM B-O
contol NOUN B-O
, PUNCT B-O
263 NUM B-O
intervention NOUN B-O
) PUNCT B-O
. PUNCT B-O

Epidemiological ADJ B-O
studies NOUN B-O
that PRON B-O
were AUX B-O
to PART B-O
be AUX B-O
included VERB B-O
in ADP B-O
the DET B-O
current ADJ B-O
meta NOUN B-O
- PUNCT B-O
analysis NOUN B-O
studies NOUN B-O
should AUX B-O
meet VERB B-O
the DET B-O
following ADJ B-O
criteria NOUN B-O
: PUNCT B-O
1 X B-O
) PUNCT B-O
was AUX B-O
a DET B-O
population- NOUN B-O
or CCONJ B-O
hospital NOUN B-O
- PUNCT B-O
based VERB B-O
, PUNCT B-O
case NOUN B-O
- PUNCT B-O
control NOUN B-O
study NOUN B-O
or CCONJ B-O
a DET B-O
prospective ADJ B-O
or CCONJ B-O
retrospective ADJ B-O
cohort NOUN B-O
study NOUN B-O
; PUNCT B-O
2 X B-O
) PUNCT B-O
provided VERB B-O
the DET B-O
coffee NOUN B-O
intake NOUN B-O
level NOUN B-O
category NOUN B-O
and CCONJ B-O
the DET B-O
corresponding ADJ B-O
relative ADJ B-LF
risk NOUN I-LF
( PUNCT B-O
RR PROPN B-AC
) PUNCT B-O
or CCONJ B-O
the DET B-O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT B-O
OR PROPN B-AC
) PUNCT B-O
estimates NOUN B-O
and CCONJ B-O
their PRON B-O
confidential ADJ B-O
intervals NOUN B-O
( PUNCT B-O
95%CIs PROPN B-AC
) PUNCT B-O
for ADP B-O
MM PROPN B-AC
; PUNCT B-O
3 X B-O
) PUNCT B-O
not PART B-O
overlapped VERB B-O
participants NOUN B-O
with ADP B-O
other ADJ B-O
included VERB B-O
studies NOUN B-O
. PUNCT B-O

Univariate ADJ B-O
and CCONJ B-O
multivariate ADJ B-O
Cox PROPN B-O
proportion NOUN B-O
hazard NOUN B-O
regression NOUN B-O
models NOUN B-O
were AUX B-O
used VERB B-O
to PART B-O
examine VERB B-O
the DET B-O
effect NOUN B-O
of ADP B-O
HCV PROPN B-AC
infection NOUN B-O
on ADP B-O
cataract NOUN B-O
risk NOUN B-O
through ADP B-O
hazard NOUN B-LF
ratios NOUN I-LF
( PUNCT B-O
HRs PROPN B-AC
) PUNCT B-O
with ADP B-O
their PRON B-O
respective ADJ B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT B-O
CIs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

HI PROPN B-AC
, PUNCT B-O
haemagglutination NOUN B-LF
inhibition NOUN I-LF
; PUNCT B-O
MCMC PROPN B-AC
, PUNCT B-O
Markov PROPN B-LF
chain NOUN I-LF
Monte PROPN I-LF
Carlo PROPN I-LF
. PUNCT B-O

Cav3 PROPN B-AC
, PUNCT B-O
Caveolin-3 PROPN B-LF
; PUNCT B-O
CM PROPN B-AC
, PUNCT B-O
cardiomyocyte NOUN B-LF
; PUNCT B-O
Ct PROPN B-AC
, PUNCT B-O
cycle NOUN B-LF
threshold NOUN I-LF
value NOUN I-LF
; PUNCT B-O
HSA PROPN B-AC
, PUNCT B-O
heat NOUN B-LF
stable ADJ I-LF
antigen NOUN I-LF
; PUNCT B-O
P PROPN B-AC
, PUNCT B-O
postnatal ADJ B-LF
day NOUN I-LF
; PUNCT B-O
qRT PROPN B-AC
, PUNCT B-O
quantitative ADJ B-LF
real ADJ I-LF
time NOUN I-LF
polymerase NOUN I-LF
chain NOUN I-LF
reaction NOUN I-LF
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
fluorescence NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
cell NOUN I-LF
sorting NOUN I-LF
( PUNCT B-O
FACS PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
of ADP B-O
cell NOUN B-O
cycle NOUN B-O
showed VERB B-O
that SCONJ B-O
ATX-3 PROPN B-AC
deletion NOUN B-O
resulted VERB B-O
in ADP B-O
an DET B-O
increased VERB B-O
proportion NOUN B-O
of ADP B-O
cells NOUN B-O
in ADP B-O
G2 NOUN B-O
/ SYM B-O
M NOUN B-O
phase NOUN B-O
( PUNCT B-O
Fig PROPN B-O
4F NUM B-O
) PUNCT B-O
. PUNCT B-O

Without ADP B-O
p53 NOUN B-O
and CCONJ B-O
ATX-3 PROPN B-AC
double ADJ B-O
KO PROPN B-AC
MEF PROPN B-AC
cells NOUN B-O
in ADP B-O
hand NOUN B-O
, PUNCT B-O
we PRON B-O
examined VERB B-O
the DET B-O
p53 NOUN B-O
- PUNCT B-O
dependence NOUN B-O
of ADP B-O
this DET B-O
effect NOUN B-O
by ADP B-O
using VERB B-O
ATX-3 PROPN B-AC
stably ADV B-O
knocked VERB B-O
down ADP B-O
HCT116 NOUN B-O
p53+/+ NOUN B-O
and CCONJ B-O
HCT116 NOUN B-O
p53-/- NOUN B-O
cells NOUN B-O
. PUNCT B-O

In ADP B-O
Latin PROPN B-LF
America PROPN I-LF
( PUNCT B-O
LA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
proportion NOUN B-O
of ADP B-O
BC PROPN B-AC
in ADP B-O
women NOUN B-O
younger ADJ B-O
than ADP B-O
45 NUM B-O
years NOUN B-O
is AUX B-O
nearly ADV B-O
twice DET B-O
the DET B-O
proportion NOUN B-O
in ADP B-O
developed VERB B-O
countries NOUN B-O
, PUNCT B-O
a DET B-O
difference NOUN B-O
that PRON B-O
is AUX B-O
only ADV B-O
partly ADV B-O
explained VERB B-O
by ADP B-O
population NOUN B-O
age NOUN B-O
structure NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
mHAI PROPN B-AC
, PUNCT B-O
modified ADJ B-LF
hepatic ADJ I-LF
activity NOUN I-LF
index NOUN I-LF
; PUNCT B-O
T2 NOUN B-O
, PUNCT B-O
T2 NOUN B-O
- PUNCT B-O
weighted VERB B-O
image NOUN B-O
; PUNCT B-O
CE PROPN B-AC
, PUNCT B-O
contrast NOUN B-O
- PUNCT B-O
enhancement NOUN B-O
; PUNCT B-O
RLE PROPN B-AC
, PUNCT B-O
relative ADJ B-LF
liver NOUN I-LF
enhancement NOUN I-LF
, PUNCT B-O
OR PROPN B-AC
, PUNCT B-O
Odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
β PUNCT B-O
, PUNCT B-O
regression NOUN B-O
coefficient NOUN B-O
; PUNCT B-O
pvp NOUN B-O
, PUNCT B-O
portal NOUN B-O
venous ADJ B-O
phase NOUN B-O
; PUNCT B-O
dp NOUN B-O
, PUNCT B-O
delayed VERB B-O
- PUNCT B-O
phase NOUN B-O
. PUNCT B-O

Although SCONJ B-O
patients NOUN B-O
supported VERB B-O
with ADP B-O
a DET B-O
Continuous PROPN B-O
- PUNCT B-O
Flow PROPN B-O
Left PROPN B-LF
Ventricular PROPN I-LF
Assist PROPN I-LF
Device PROPN I-LF
( PUNCT B-O
CF-LVAD PROPN B-AC
) PUNCT B-O
are AUX B-O
hemodynamically ADV B-O
stable ADJ B-O
, PUNCT B-O
their PRON B-O
exercise NOUN B-O
capacity NOUN B-O
is AUX B-O
limited ADJ B-O
. PUNCT B-O

MAD PROPN B-AC
: PUNCT B-O
median ADJ B-LF
absolute ADJ I-LF
deviation NOUN I-LF
, PUNCT B-O
NOTFront PROPN B-AC
: PUNCT B-O
percentage NOUN B-O
of ADP B-O
misclassified VERB B-O
DMUs PROPN B-AC
, PUNCT B-O
PU20 NUM B-O
% NOUN B-O
: PUNCT B-O
percentage NOUN B-O
of ADP B-O
underestimation NOUN B-O
, PUNCT B-O
PO20 NUM B-O
% NOUN B-O
: PUNCT B-O
percentage NOUN B-O
of ADP B-O
overestimation NOUN B-O
, PUNCT B-O
rs NOUN B-O
: PUNCT B-O
Spearman PROPN B-O
’s PART B-O
rank NOUN B-O
correlation NOUN B-O
. PUNCT B-O

CLANS PROPN B-AC
, PUNCT B-O
cluster NOUN B-LF
analysis NOUN I-LF
of ADP I-LF
sequences NOUN I-LF
; PUNCT B-O
MPP PROPN B-AC
, PUNCT B-O
mitochondrial ADJ B-O
processing NOUN B-O
peptide NOUN B-O
; PUNCT B-O
PreP PROPN B-AC
, PUNCT B-O
presequence NOUN B-LF
protease NOUN I-LF
; PUNCT B-O
SPP PROPN B-AC
, PUNCT B-O
stromal NOUN B-LF
processing NOUN I-LF
peptidase NOUN I-LF
. PUNCT B-O

Washed VERB B-O
rod NOUN B-O
outer ADJ B-O
segment NOUN B-O
membranes NOUN B-O
prepared VERB B-O
from ADP B-O
fresh ADJ B-O
bovine ADJ B-O
retinas NOUN B-O
[ X B-O
36 X B-O
] PUNCT B-O
and CCONJ B-O
cell NOUN B-O
membranes NOUN B-O
of ADP B-O
TE671 PROPN B-O
cells NOUN B-O
infected VERB B-O
with ADP B-O
either CCONJ B-O
EF1α NOUN B-O
- PUNCT B-O
GC1 PROPN B-AC
- PUNCT B-O
IRES PROPN B-AC
- PUNCT B-O
eGFP NOUN B-O
or CCONJ B-O
EF1α NOUN B-O
- PUNCT B-O
eGFP NOUN B-O
virus NOUN B-O
were AUX B-O
reconstituted VERB B-O
with ADP B-O
recombinant ADJ B-O
guanylate NOUN B-LF
cyclase NOUN I-LF
activating VERB I-LF
protein–1 NOUN I-LF
( PUNCT B-O
GCAP1 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
assayed VERB B-O
for ADP B-O
GC1 PROPN B-AC
activity NOUN B-O
as SCONJ B-O
previously ADV B-O
described VERB B-O
[ X B-O
37 X B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
Multiple PROPN B-LF
Sclerosis PROPN I-LF
Impact PROPN I-LF
Scale–29 PROPN I-LF
( PUNCT B-O
MSIS-29 PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
PRO PROPN B-AC
that PRON B-O
attempts VERB B-O
to PART B-O
assess VERB B-O
both CCONJ B-O
physical ADJ B-O
and CCONJ B-O
psychological ADJ B-O
quality NOUN B-O
of ADP B-O
life NOUN B-O
in ADP B-O
multiple ADJ B-LF
sclerosis NOUN I-LF
( PUNCT B-O
MS PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
14 NUM B-O
] PUNCT B-O
. PUNCT B-O

By ADP B-O
comparing VERB B-O
the DET B-O
gene NOUN B-O
expression NOUN B-O
ratio NOUN B-O
between ADP B-O
the DET B-O
two NUM B-O
species NOUN B-O
and CCONJ B-O
the DET B-O
allele NOUN B-LF
- ADJ I-LF
specific ADJ I-LF
expression NOUN I-LF
( PUNCT B-O
ASE PROPN B-AC
) PUNCT B-O
ratio NOUN B-O
in ADP B-O
the DET B-O
F1 PROPN B-AC
hybrids NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1D NUM B-O
) PUNCT B-O
, PUNCT B-O
we PRON B-O
assessed VERB B-O
the DET B-O
total ADJ B-O
number NOUN B-O
of ADP B-O
genes NOUN B-O
whose DET B-O
expression NOUN B-O
differs VERB B-O
by ADP B-O
divergence NOUN B-O
in ADP B-O
cis- ADJ B-O
versus ADP B-O
trans ADJ B-O
- ADJ B-O
transcriptional ADJ B-O
regulation NOUN B-O
between ADP B-O
the DET B-O
two NUM B-O
species NOUN B-O
. PUNCT B-O

Ins PROPN B-O
= PUNCT B-O
inositol NOUN B-O
peak NOUN B-O
, PUNCT B-O
Cho PROPN B-AC
= PUNCT B-O
choline NOUN B-LF
peak NOUN B-O
, PUNCT B-O
Cr PROPN B-AC
= PUNCT B-O
creatine NOUN B-LF
/ SYM I-LF
phosphocreatine NOUN I-LF
peak NOUN B-O
, PUNCT B-O
Glx PROPN B-AC
= PUNCT B-O
glutamate NOUN B-O
/ SYM B-O
glutamine NOUN B-O
peaks NOUN B-O
, PUNCT B-O
NAA PROPN B-AC
= PUNCT B-O
N NOUN B-O
- PUNCT B-O
acetyl NOUN B-O
- PUNCT B-O
aspartate NOUN B-O
peak NOUN B-O
. PUNCT B-O

In ADP B-O
model NOUN B-O
A NOUN B-O
, PUNCT B-O
participants NOUN B-O
< ADP B-O
30 NUM B-O
years NOUN B-O
old ADJ B-O
were AUX B-O
more ADV B-O
likely ADJ B-O
to PART B-O
have VERB B-O
good ADJ B-O
SRH PROPN B-AC
( PUNCT B-O
Odds NOUN B-LF
Ratio NOUN I-LF
( PUNCT B-O
OR PROPN B-AC
) PUNCT B-O
= SYM B-O
2.022 NUM B-O
) PUNCT B-O
than ADP B-O
participants NOUN B-O
> ADP B-O
50 NUM B-O
. PUNCT B-O

AbSensitivity PROPN B-O
( PUNCT B-O
Antibiotic ADJ B-O
sensitivity NOUN B-O
) PUNCT B-O
, PUNCT B-O
Ca PROPN B-AC
- PUNCT B-O
Solub PROPN B-O
( PUNCT B-O
Calcium NOUN B-LF
solubilization NOUN B-O
) PUNCT B-O
, PUNCT B-O
Zn PROPN B-AC
- PUNCT B-O
Solub PROPN B-O
( PUNCT B-O
Zinc NOUN B-LF
solubilization NOUN B-O
) PUNCT B-O
, PUNCT B-O
K PROPN B-AC
- PUNCT B-O
Solub PROPN B-O
( PUNCT B-O
potassium NOUN B-LF
solubilization NOUN B-O
) PUNCT B-O
, PUNCT B-O
Mg PROPN B-AC
- PUNCT B-O
Solub PROPN B-O
( PUNCT B-O
magnesium NOUN B-LF
solubilization NOUN B-O
) PUNCT B-O
, PUNCT B-O
P PROPN B-AC
- PUNCT B-O
Solub PROPN B-O
( PUNCT B-O
phosphorus NOUN B-LF
solubilization NOUN B-O
) PUNCT B-O
. PUNCT B-O

During ADP B-O
the DET B-O
consultation NOUN B-O
, PUNCT B-O
clinical ADJ B-O
signs NOUN B-O
of ADP B-O
a DET B-O
relevant ADJ B-O
focused ADJ B-O
examination NOUN B-O
were AUX B-O
also ADV B-O
recorded VERB B-O
( PUNCT B-O
vital ADJ B-O
and CCONJ B-O
danger NOUN B-O
signs NOUN B-O
, PUNCT B-O
temperature NOUN B-O
, PUNCT B-O
respiratory ADJ B-O
rate NOUN B-O
, PUNCT B-O
malnutrition NOUN B-O
assessment NOUN B-O
, PUNCT B-O
etc X B-O
. PUNCT B-O

) PUNCT B-O
along ADP B-O
with ADP B-O
laboratory NOUN B-O
tests NOUN B-O
recommended VERB B-O
by ADP B-O
the DET B-O
app NOUN B-O
( PUNCT B-O
mRDT PROPN B-AC
, PUNCT B-O
C NOUN B-LF
- PUNCT I-LF
reactive ADJ I-LF
protein NOUN I-LF
[ PUNCT B-O
CRP PROPN B-AC
] PUNCT B-O
, PUNCT B-O
hemoglobin NOUN B-O
, PUNCT B-O
urinary ADJ B-O
dipstick NOUN B-O
, PUNCT B-O
etc X B-O
. PUNCT B-O

) PUNCT B-O
. PUNCT B-O

Pre NOUN B-LF
- PUNCT I-LF
eclampsia NOUN I-LF
( PUNCT B-O
PE PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
common ADJ B-O
pregnancy NOUN B-O
- PUNCT B-O
related VERB B-O
complication NOUN B-O
affecting VERB B-O
3 NUM B-O
% NOUN B-O
of ADP B-O
all DET B-O
pregnancies NOUN B-O
. PUNCT B-O

Other ADJ B-O
liver NOUN B-O
reserve NOUN B-O
markers NOUN B-O
, PUNCT B-O
fibrosis NOUN B-LF
index NOUN I-LF
based VERB I-LF
on ADP I-LF
4 NUM I-LF
factors NOUN I-LF
( PUNCT B-O
FIB-4 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
platelet NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
APRI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
have AUX B-O
also ADV B-O
been AUX B-O
proposed VERB B-O
to PART B-O
assess VERB B-O
liver NOUN B-O
dysfunction NOUN B-O
[ PUNCT B-O
16 NUM B-O
, PUNCT B-O
17 NUM B-O
] PUNCT B-O
. PUNCT B-O

District NOUN B-O
and CCONJ B-O
health NOUN B-O
centre NOUN B-O
heads NOUN B-O
, PUNCT B-O
neglected VERB B-O
tropical ADJ B-O
diseases NOUN B-O
( PUNCT B-O
NTD NOUN B-O
) PUNCT B-O
focal ADJ B-O
persons NOUN B-O
and CCONJ B-O
integrated VERB B-LF
eye NOUN I-LF
care NOUN I-LF
workers NOUN I-LF
( PUNCT B-O
IECWs PROPN B-AC
) PUNCT B-O
were AUX B-O
involved VERB B-O
in ADP B-O
the DET B-O
key ADJ B-O
informant NOUN B-O
in ADP B-O
- PUNCT B-O
depth NOUN B-O
interview NOUN B-O
. PUNCT B-O

ART PROPN B-AC
, PUNCT B-O
artemisinin PROPN B-LF
; PUNCT B-O
IC50 PROPN B-AC
, PUNCT B-O
concentration NOUN B-O
of ADP B-O
half ADJ B-O
- PUNCT B-O
maximal ADJ B-O
inhibition NOUN B-O
. PUNCT B-O

n NOUN B-O
= VERB B-O
number NOUN B-O
of ADP B-O
cases NOUN B-O
; PUNCT B-O
OR PROPN B-AC
= VERB B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
= VERB B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
IQR PROPN B-AC
= VERB B-O
interquartile ADJ B-LF
range NOUN I-LF
; PUNCT B-O
HIV PROPN B-AC
= VERB B-O
human ADJ B-LF
immunodeficiency NOUN I-LF
virus NOUN I-LF
; PUNCT B-O
TB PROPN B-AC
= VERB B-O
tuberculosis NOUN B-LF
; PUNCT B-O
pre PROPN B-AC
= VERB B-O
resistance NOUN B-O
to ADP B-O
one NUM B-O
or CCONJ B-O
more ADJ B-O
second ADJ B-O
- PUNCT B-O
line NOUN B-O
injectable ADJ B-O
drugs NOUN B-O
; PUNCT B-O
-XDRSLID-TBpre PROPN B-AC
= VERB B-O
resistance NOUN B-O
to ADP B-O
one NUM B-O
or CCONJ B-O
more ADJ B-O
fluoroquinolones NOUN B-O
. PUNCT B-O

SMC PROPN B-AC
, PUNCT B-O
seasonal ADJ B-LF
malaria NOUN I-LF
chemoprevention NOUN I-LF
. PUNCT B-O

In ADP B-O
the DET B-O
present ADJ B-O
experimental ADJ B-O
setting NOUN B-O
, PUNCT B-O
adult ADJ B-O
male ADJ B-O
C57BL PROPN B-O
/ SYM B-O
N6 NUM B-O
mice NOUN B-O
were AUX B-O
either CCONJ B-O
flown VERB B-O
aboard ADV B-O
the DET B-O
BION PROPN B-O
- PUNCT B-O
M1 PROPN B-O
biosatellite NOUN B-O
for ADP B-O
30 NUM B-O
days NOUN B-O
on ADP B-O
orbit NOUN B-O
( PUNCT B-O
BION PROPN B-O
- PUNCT B-O
flown VERB B-O
= PUNCT B-O
BF PROPN B-AC
) PUNCT B-O
or CCONJ B-O
housed VERB B-O
as SCONJ B-O
sex- NOUN B-O
and CCONJ B-O
age NOUN B-O
- PUNCT B-O
matched VERB B-O
cohorts NOUN B-O
( PUNCT B-O
n NOUN B-O
= PUNCT B-O
5 NUM B-O
each PRON B-O
) PUNCT B-O
in ADP B-O
a DET B-O
replicate ADJ B-O
flight NOUN B-O
habitat NOUN B-O
on ADP B-O
Earth PROPN B-O
( PUNCT B-O
BION PROPN B-O
- PUNCT B-O
ground NOUN B-O
= PUNCT B-O
BG PROPN B-AC
) PUNCT B-O
as SCONJ B-O
reference NOUN B-O
flight NOUN B-LF
control NOUN I-LF
, PUNCT B-O
and CCONJ B-O
in ADP B-O
standard ADJ B-O
animal NOUN B-O
cages NOUN B-O
concomitant ADJ B-O
to ADP B-O
the DET B-O
duration NOUN B-O
of ADP B-O
the DET B-O
biosatellite NOUN B-O
flight NOUN B-O
( PUNCT B-O
flight NOUN B-LF
control NOUN I-LF
= PUNCT B-O
FC PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Mice NOUN B-O
flown VERB B-O
aboard ADV B-O
of ADP B-O
the DET B-O
biosatellite NOUN B-O
were AUX B-O
in ADP B-O
good ADJ B-O
condition NOUN B-O
after ADP B-O
landing NOUN B-O
, PUNCT B-O
as SCONJ B-O
previously ADV B-O
reported VERB B-O
by ADP B-O
Andreev PROPN B-O
- PUNCT B-O
Andrievskiy PROPN B-O
[ PUNCT B-O
17 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
this DET B-O
study NOUN B-O
, PUNCT B-O
we PRON B-O
sought VERB B-O
to PART B-O
test VERB B-O
whether SCONJ B-O
elevated ADJ B-O
levels NOUN B-O
of ADP B-O
Arc PROPN B-O
interfere VERB B-O
with ADP B-O
brain NOUN B-LF
- PUNCT I-LF
derived VERB I-LF
neurotrophic ADJ I-LF
factor NOUN I-LF
( PUNCT B-O
BDNF PROPN B-AC
) PUNCT B-O
TrkB PROPN B-O
receptor NOUN B-O
signaling NOUN B-O
, PUNCT B-O
which PRON B-O
is AUX B-O
known VERB B-O
to PART B-O
be AUX B-O
essential ADJ B-O
for ADP B-O
both CCONJ B-O
the DET B-O
induction NOUN B-O
and CCONJ B-O
maintenance NOUN B-O
of ADP B-O
LTP PROPN B-AC
. PUNCT B-O

We PRON B-O
report VERB B-O
that SCONJ B-O
TrkB PROPN B-O
signaling NOUN B-O
in ADP B-O
the DET B-O
AS PROPN B-AC
mouse NOUN B-O
is AUX B-O
defective ADJ B-O
, PUNCT B-O
and CCONJ B-O
show VERB B-O
that SCONJ B-O
reduction NOUN B-O
of ADP B-O
Arc PROPN B-O
expression NOUN B-O
to PART B-O
control VERB B-O
levels NOUN B-O
rescues VERB B-O
the DET B-O
signaling NOUN B-O
deficits NOUN B-O
. PUNCT B-O

One NUM B-O
key NOUN B-O
molecule NOUN B-O
in ADP B-O
this DET B-O
process NOUN B-O
is AUX B-O
an DET B-O
enzyme NOUN B-O
named VERB B-O
D NOUN B-LF
- NOUN I-LF
aminoacyl NOUN I-LF
- NOUN I-LF
tRNA NOUN I-LF
deacylase NOUN I-LF
( PUNCT B-O
DTD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
hydrolyses VERB B-O
D NOUN B-O
- NOUN B-O
amino NOUN B-O
acids NOUN B-O
attached VERB B-O
to ADP B-O
tRNA NOUN B-O
molecules NOUN B-O
( PUNCT B-O
a DET B-O
D NOUN B-O
- NOUN B-O
aminoacyl NOUN B-O
- NOUN B-O
tRNA NOUN B-O
) PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
show VERB B-O
that SCONJ B-O
besides SCONJ B-O
acting VERB B-O
on ADP B-O
D NOUN B-O
- NOUN B-O
aminoacyl NOUN B-O
- NOUN B-O
tRNA NOUN B-O
, PUNCT B-O
DTD PROPN B-AC
also ADV B-O
efficiently ADV B-O
hydrolyses VERB B-O
the DET B-O
achiral ADJ B-O
glycine NOUN B-O
attached VERB B-O
to ADP B-O
tRNA NOUN B-O
— PUNCT B-O
glycyl NOUN B-O
- NOUN B-O
tRNA(Gly)—as NOUN B-O
DTD PROPN B-AC
’s PART B-O
active ADJ B-O
site NOUN B-O
pocket NOUN B-O
can AUX B-O
not PART B-O
discriminate VERB B-O
between ADP B-O
D NOUN B-O
- NOUN B-O
amino NOUN B-O
acids NOUN B-O
and CCONJ B-O
glycine NOUN B-O
. PUNCT B-O

SVR PROPN B-AC
response NOUN B-O
rates NOUN B-O
were AUX B-O
calculated VERB B-O
using VERB B-O
relative ADJ B-LF
risk NOUN I-LF
( PUNCT B-O
RR PROPN B-AC
) PUNCT B-O
differences NOUN B-O
using VERB B-O
chi NOUN B-O
- PUNCT B-O
square ADJ B-O
test NOUN B-O
. PUNCT B-O

The DET B-O
São PROPN B-LF
Paulo PROPN I-LF
Autopsy PROPN I-LF
Service PROPN I-LF
( PUNCT B-O
SPAS PROPN B-AC
) PUNCT B-O
is AUX B-O
the DET B-O
only ADJ B-O
morgue NOUN B-O
serving VERB B-O
the DET B-O
metropolitan ADJ B-O
area NOUN B-O
of ADP B-O
São PROPN B-O
Paulo PROPN B-O
( PUNCT B-O
Brazil PROPN B-O
) PUNCT B-O
. PUNCT B-O

Consistent ADJ B-O
with ADP B-O
our PRON B-O
hypothesis NOUN B-O
, PUNCT B-O
we PRON B-O
found VERB B-O
that SCONJ B-O
a DET B-O
strong ADJ B-O
phospho NOUN B-O
- PUNCT B-O
Rb PROPN B-AC
S249 PROPN B-O
staining NOUN B-O
positively ADV B-O
correlated VERB B-O
with ADP B-O
tumor NOUN B-O
grade NOUN B-O
exclusively ADV B-O
in ADP B-O
squamous ADJ B-LF
cell NOUN I-LF
carcinomas NOUN I-LF
( PUNCT B-O
SCC PROPN B-AC
) PUNCT B-O
and CCONJ B-O
not PART B-O
in ADP B-O
adenocarcinomas NOUN B-LF
( PUNCT B-O
AC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
meaning VERB B-O
that SCONJ B-O
most ADJ B-O
of ADP B-O
the DET B-O
SCC PROPN B-AC
tumors NOUN B-O
with ADP B-O
higher ADJ B-O
grades NOUN B-O
also ADV B-O
had VERB B-O
high ADJ B-O
scores NOUN B-O
for ADP B-O
phospho NOUN B-O
- PUNCT B-O
Rb PROPN B-AC
S249 PROPN B-O
positive ADJ B-O
cells NOUN B-O
. PUNCT B-O

An DET B-O
observation NOUN B-O
that PRON B-O
seems VERB B-O
to PART B-O
be AUX B-O
at ADP B-O
odds NOUN B-O
with ADP B-O
the DET B-O
findings NOUN B-O
from ADP B-O
these DET B-O
ex X B-O
vivo X B-O
studies NOUN B-O
is AUX B-O
that PRON B-O
the DET B-O
eyeblink NOUN B-O
conditioned VERB B-LF
response NOUN I-LF
( PUNCT B-O
CR PROPN B-AC
) PUNCT B-O
is AUX B-O
well ADV B-O
- PUNCT B-O
predicted VERB B-O
by ADP B-O
a DET B-O
suppression NOUN B-O
in ADP B-O
Purkinje PROPN B-O
cell NOUN B-O
simple ADJ B-O
spike NOUN B-O
firing NOUN B-O
that PRON B-O
may AUX B-O
last VERB B-O
for ADP B-O
several ADJ B-O
hundreds NOUN B-O
of ADP B-O
milliseconds NOUN B-O
[ X B-O
28–31 NUM B-O
] PUNCT B-O
. PUNCT B-O

While SCONJ B-O
PQ PROPN B-AC
is AUX B-O
tolerated VERB B-O
in ADP B-O
most ADJ B-O
patients NOUN B-O
, PUNCT B-O
it PRON B-O
can AUX B-O
cause VERB B-O
haemolysis NOUN B-O
in ADP B-O
patients NOUN B-O
with ADP B-O
glucose-6 NOUN B-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
deficiency NOUN I-LF
( PUNCT B-O
G6PDd PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
severity NOUN B-O
of ADP B-O
which PRON B-O
is AUX B-O
dependent ADJ B-O
on ADP B-O
the DET B-O
underlying VERB B-O
genetic ADJ B-O
variant NOUN B-O
, PUNCT B-O
the DET B-O
dose NOUN B-O
of ADP B-O
PQ PROPN B-AC
administered VERB B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
age NOUN B-O
of ADP B-O
the DET B-O
patient NOUN B-O
’s PART B-O
red ADJ B-LF
blood NOUN I-LF
cell NOUN I-LF
( PUNCT B-O
RBC PROPN B-AC
) PUNCT B-O
population NOUN B-O
[ X B-O
7,8 NUM B-O
] PUNCT B-O
. PUNCT B-O

BAC PROPN B-AC
, PUNCT B-O
bacterial ADJ B-LF
artificial ADJ I-LF
chromosome NOUN I-LF
; PUNCT B-O
CENP PROPN B-AC
, PUNCT B-O
centromere NOUN B-LF
protein NOUN I-LF
A NOUN I-LF
; PUNCT B-O
-ACenX PROPN B-AC
, PUNCT B-O
X NOUN B-LF
centromere NOUN I-LF
; PUNCT B-O
ChIP PROPN B-AC
, PUNCT B-O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
sequencing NOUN B-O
; PUNCT B-O
-seqCRM PROPN B-AC
, PUNCT B-O
centromeric ADJ B-LF
retrotransposons NOUN I-LF
of ADP I-LF
maize NOUN I-LF
; PUNCT B-O
CRR PROPN B-AC
, PUNCT B-O
centromeric ADJ B-LF
retrotransposons NOUN I-LF
of ADP I-LF
rice NOUN I-LF
; PUNCT B-O
CRW PROPN B-AC
, PUNCT B-O
centromeric ADJ B-LF
retrotransposons NOUN I-LF
of ADP I-LF
wheat NOUN I-LF
; PUNCT B-O
FISH PROPN B-AC
, PUNCT B-O
fluorescence NOUN B-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
; PUNCT B-O
LAVA PROPN B-AC
, PUNCT B-O
LINE PROPN B-LF
- PUNCT I-LF
LINE PROPN B-AC
Alu PROPN I-LF
- PUNCT I-LF
VNTR PROPN I-LF
- PUNCT I-LF
Alu PROPN I-LF
- PUNCT I-LF
like ADJ I-LF
; PUNCT B-O
LINE PROPN B-AC
, PUNCT B-O
long ADJ B-LF
interspersed VERB I-LF
nuclear ADJ I-LF
element NOUN I-LF
; PUNCT B-O
LTR PROPN B-AC
, PUNCT B-O
long ADJ B-LF
terminal ADJ I-LF
repeat NOUN I-LF
; PUNCT B-O
Mya PROPN B-O
, PUNCT B-O
million NUM B-O
years NOUN B-O
ago ADV B-O
. PUNCT B-O

Recently ADV B-O
, PUNCT B-O
we PRON B-O
developed VERB B-O
a DET B-O
novel ADJ B-O
and CCONJ B-O
sensitive ADJ B-O
XOR PROPN B-AC
assay NOUN B-O
for ADP B-O
the DET B-O
measurement NOUN B-O
of ADP B-O
human ADJ B-O
plasma NOUN B-O
XOR PROPN B-AC
activity NOUN B-O
that PRON B-O
is AUX B-O
based VERB B-O
on ADP B-O
[ X B-O
13C2,15N2]xanthine NOUN B-O
coupled VERB B-O
with ADP B-O
liquid NOUN B-LF
chromatography NOUN I-LF
( PUNCT B-O
mass NOUN I-LF
LC)/triplequadrupole PROPN B-AC
spectrometry NOUN I-LF
( PUNCT B-O
TQMS PROPN B-AC
) PUNCT B-O
[ X B-O
18,19 NUM B-O
] PUNCT B-O
. PUNCT B-O

Cadherins NOUN B-O
form VERB B-O
an DET B-O
adhesive ADJ B-O
interface NOUN B-O
all ADV B-O
along ADP B-O
the DET B-O
lateral ADJ B-O
domain NOUN B-O
but CCONJ B-O
are AUX B-O
also ADV B-O
organised VERB B-O
into ADP B-O
special ADJ B-O
complexes NOUN B-O
known VERB B-O
as ADP B-O
zonula NOUN B-LF
adherens NOUN I-LF
( PUNCT B-O
ZA PROPN B-AC
) PUNCT B-O
that PRON B-O
are AUX B-O
localised VERB B-O
at ADP B-O
the DET B-O
apical ADJ B-O
end NOUN B-O
. PUNCT B-O

At ADP B-O
baseline NOUN B-O
, PUNCT B-O
mothers NOUN B-O
had VERB B-O
weight NOUN B-O
, PUNCT B-O
mid ADJ B-LF
- ADJ I-LF
upper ADJ I-LF
arm NOUN I-LF
circumference NOUN I-LF
( PUNCT B-O
MUAC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
hemoglobin NOUN B-O
( PUNCT B-O
Hemocue PROPN B-O
, PUNCT B-O
Ängelholm PROPN B-O
, PUNCT B-O
Sweden PROPN B-O
) PUNCT B-O
measured VERB B-O
, PUNCT B-O
and CCONJ B-O
were AUX B-O
tested VERB B-O
for ADP B-O
HIV PROPN B-O
using VERB B-O
a DET B-O
rapid ADJ B-O
test NOUN B-O
algorithm NOUN B-O
. PUNCT B-O

Disease PROPN B-O
activity NOUN B-O
reflected VERB B-O
the DET B-O
direct ADJ B-O
results NOUN B-O
of ADP B-O
treatment NOUN B-O
, PUNCT B-O
as SCONJ B-O
measured VERB B-O
with ADP B-O
the DET B-O
Disease PROPN B-LF
Activity PROPN I-LF
Score–28 NUM I-LF
with ADP I-LF
erythrocyte NOUN I-LF
sedimentation NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
DAS28-ESR PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
33 NUM B-O
] PUNCT B-O
. PUNCT B-O

AUC PROPN B-AC
, PUNCT B-O
area NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
; PUNCT B-O
CITL PROPN B-O
, PUNCT B-O
calibration NOUN B-O
in ADP B-O
the DET B-O
large ADJ B-O
; PUNCT B-O
E NOUN B-O
:O NOUN B-O
, PUNCT B-O
ratio NOUN B-O
of ADP B-O
expected VERB B-O
( PUNCT B-O
predicted VERB B-O
) PUNCT B-O
probability NOUN B-O
vs ADP B-O
observed ADJ B-O
frequency NOUN B-O
of ADP B-O
the DET B-O
outcome NOUN B-O
; PUNCT B-O
STm PROPN B-AC
, PUNCT B-O
symptoms NOUN B-LF
and CCONJ I-LF
tests NOUN I-LF
model NOUN I-LF
; PUNCT B-O
Tm PROPN B-AC
, PUNCT B-O
tests NOUN B-LF
- PUNCT I-LF
only ADV I-LF
model NOUN I-LF
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
GPi PROPN B-AC
, PUNCT B-O
globus NOUN B-LF
pallidus X I-LF
- PUNCT I-LF
internus X I-LF
; PUNCT B-O
max NOUN B-O
, PUNCT B-O
maximum NOUN B-O
; PUNCT B-O
min NOUN B-O
, PUNCT B-O
minimum NOUN B-O
; PUNCT B-O
Mvt PROPN B-O
, PUNCT B-O
movement NOUN B-O
; PUNCT B-O
NHP PROPN B-AC
, PUNCT B-O
nonhuman ADJ B-LF
primate NOUN I-LF
; PUNCT B-O
sp NOUN B-O
, PUNCT B-O
spikes NOUN B-O
; PUNCT B-O
VLa PROPN B-AC
, PUNCT B-O
ventrolateral ADJ B-LF
anterior ADJ I-LF
nucleus NOUN I-LF
Recently ADV B-O
, PUNCT B-O
it PRON B-O
was AUX B-O
reported VERB B-O
that SCONJ B-O
5 NUM B-LF
- PUNCT I-LF
HT2 NOUN I-LF
receptors NOUN I-LF
( PUNCT B-O
5-HT2Rs PROPN B-AC
) PUNCT B-O
were AUX B-O
expressed VERB B-O
in ADP B-O
cartilage NOUN B-O
tissues NOUN B-O
lacking VERB B-O
both CCONJ B-O
vessels NOUN B-O
and CCONJ B-O
neurons NOUN B-O
, PUNCT B-O
suggesting VERB B-O
possible ADJ B-O
novel ADJ B-O
functions NOUN B-O
of ADP B-O
5-HT PROPN B-AC
during ADP B-O
cartilage NOUN B-O
development NOUN B-O
and CCONJ B-O
regeneration NOUN B-O
. PUNCT B-O

MOI PROPN B-AC
, PUNCT B-O
multiplicity NOUN B-LF
of ADP I-LF
infection NOUN I-LF
. PUNCT B-O

Changes NOUN B-O
in ADP B-O
anthropometric ADJ B-O
indices NOUN B-O
[ PUNCT B-O
Weight NOUN B-O
, PUNCT B-O
Body PROPN B-O
- PUNCT B-O
Mass NOUN B-O
- PUNCT B-O
Index PROPN B-O
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
waist NOUN B-O
- PUNCT B-O
circumference NOUN B-O
( PUNCT B-O
WC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
waist NOUN B-O
- PUNCT B-O
hip NOUN B-O
ratio NOUN B-O
( PUNCT B-O
WHR PROPN B-AC
) PUNCT B-O
] PUNCT B-O
, PUNCT B-O
clinical ADJ B-O
[ PUNCT B-O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
( PUNCT B-O
SBP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
diastolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
( PUNCT B-O
DBP PROPN B-AC
) PUNCT B-O
] PUNCT B-O
and CCONJ B-O
biochemical ADJ B-O
measurements NOUN B-O
[ PUNCT B-O
Triglycerides NOUN B-LF
( PUNCT B-O
TG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
High ADJ B-LF
Density NOUN I-LF
Lipoprotein NOUN I-LF
( PUNCT B-O
HDL PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Total PROPN B-LF
Cholesterol PROPN I-LF
( PUNCT B-O
TC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
HbA1c% PROPN B-AC
] PUNCT B-O
at ADP B-O
baseline NOUN B-O
and CCONJ B-O
follow NOUN B-O
- PUNCT B-O
up ADP B-O
were AUX B-O
compared VERB B-O
. PUNCT B-O

Significance NOUN B-O
was AUX B-O
calculated VERB B-O
by ADP B-O
a DET B-O
two NUM B-O
- PUNCT B-O
tailed ADJ B-O
t NOUN B-O
test NOUN B-O
. PUNCT B-O

* PUNCT B-O
p NOUN B-O
= SYM B-O
0.03 NUM B-O
. PUNCT B-O

( PUNCT B-O
B NOUN B-O
) PUNCT B-O
HMWCK PROPN B-AC
( PUNCT B-O
high ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
cytokeratin NOUN I-LF
) PUNCT B-O
staining NOUN B-O
, PUNCT B-O
whose DET B-O
expression NOUN B-O
in ADP B-O
upper ADJ B-O
layers NOUN B-O
marks VERB B-O
squamous ADJ B-O
stratifying VERB B-O
epithelia NOUN B-O
. PUNCT B-O

( PUNCT B-O
C NOUN B-O
) PUNCT B-O
Staining NOUN B-O
for ADP B-O
TMPRSS11B NOUN B-O
, PUNCT B-O
a DET B-O
marker NOUN B-O
of ADP B-O
squamous ADJ B-O
epithelia NOUN B-O
. PUNCT B-O

( PUNCT B-O
D NOUN B-O
, PUNCT B-O
E NOUN B-O
) PUNCT B-O
Lenti PROPN B-O
- PUNCT B-O
SOX2 PROPN B-O
induces VERB B-O
hyperplasia NOUN B-O
. PUNCT B-O

Taiwan PROPN B-O
’s PART B-O
National PROPN B-LF
Health PROPN I-LF
Insurance PROPN I-LF
( PUNCT B-O
NHI PROPN B-AC
) PUNCT B-O
program NOUN B-O
is AUX B-O
a DET B-O
universal ADJ B-O
insurance NOUN B-O
program NOUN B-O
that PRON B-O
was AUX B-O
launched VERB B-O
in ADP B-O
1995 NUM B-O
. PUNCT B-O

We PRON B-O
conducted VERB B-O
a DET B-O
meta NOUN B-O
- ADJ B-O
analysis NOUN B-O
and CCONJ B-O
meta NOUN B-O
- ADJ B-O
regression NOUN B-O
of ADP B-O
randomized ADJ B-LF
controlled VERB I-LF
trials NOUN I-LF
( PUNCT B-O
RCTs PROPN B-AC
) PUNCT B-O
evaluating VERB B-O
SGLT2i PROPN B-AC
in ADP B-O
T1DM PROPN B-AC
to PART B-O
assess VERB B-O
moderators NOUN B-O
of ADP B-O
the DET B-O
relative ADJ B-LF
risk NOUN I-LF
( PUNCT B-O
RR PROPN B-AC
) PUNCT B-O
of ADP B-O
DKA PROPN B-AC
, PUNCT B-O
of ADP B-O
glycemic ADJ B-O
( PUNCT B-O
HbA1c NOUN B-O
, PUNCT B-O
fasting VERB B-O
plasma NOUN B-O
glucose NOUN B-O
, PUNCT B-O
continuous ADJ B-O
glucose NOUN B-O
monitoring NOUN B-O
parameters NOUN B-O
, PUNCT B-O
insulin NOUN B-O
dose NOUN B-O
, PUNCT B-O
and CCONJ B-O
insulin NOUN B-O
sensitivity NOUN B-O
indices NOUN B-O
) PUNCT B-O
and CCONJ B-O
non ADJ B-O
- ADJ B-O
glycemic ADJ B-O
( PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
systolic ADJ B-O
BP PROPN B-AC
, PUNCT B-O
renal ADJ B-O
function NOUN B-O
, PUNCT B-O
albuminuria NOUN B-O
, PUNCT B-O
and CCONJ B-O
diabetic ADJ B-O
eye NOUN B-O
disorders NOUN B-O
) PUNCT B-O
efficacy NOUN B-O
, PUNCT B-O
and CCONJ B-O
of ADP B-O
other ADJ B-O
safety NOUN B-O
outcomes NOUN B-O
( PUNCT B-O
including VERB B-O
hypoglycemia NOUN B-O
, PUNCT B-O
infections NOUN B-O
, PUNCT B-O
major ADJ B-O
adverse ADJ B-O
cardiovascular ADJ B-O
events NOUN B-O
, PUNCT B-O
and CCONJ B-O
death NOUN B-O
) PUNCT B-O
. PUNCT B-O

Diffusion PROPN B-LF
Tensor PROPN I-LF
Imaging PROPN I-LF
( PUNCT B-O
DTI PROPN B-AC
) PUNCT B-O
studies NOUN B-O
suggest VERB B-O
that SCONJ B-O
at ADP B-O
birth NOUN B-O
all DET B-O
major ADJ B-O
fiber NOUN B-O
systems NOUN B-O
are AUX B-O
in ADP B-O
place NOUN B-O
, PUNCT B-O
despite SCONJ B-O
low ADJ B-O
anisotropy NOUN B-O
value NOUN B-O
[ PUNCT B-O
70 NUM B-O
] PUNCT B-O
and CCONJ B-O
incomplete ADJ B-O
myelination NOUN B-O
[ PUNCT B-O
71 NUM B-O
] PUNCT B-O
. PUNCT B-O

Increasing VERB B-O
phytoene NOUN B-O
concentrations NOUN B-O
favor VERB B-O
phytofluene NOUN B-LF
release NOUN B-O
, PUNCT B-O
with ADP B-O
the DET B-O
z PROPN B-AC
: NOUN B-O
pf PROPN B-AC
ratio NOUN B-O
decreasing VERB B-O
from ADP B-O
ca X B-O
. PUNCT B-O

4:1 NUM B-O
to ADP B-O
1:1 NUM B-O
( PUNCT B-O
Fig NOUN B-O
6B NUM B-O
, PUNCT B-O
dotted ADJ B-O
line NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
underlying ADJ B-O
numerical ADJ B-O
data NOUN B-O
for ADP B-O
this DET B-O
figure NOUN B-O
can AUX B-O
be AUX B-O
found VERB B-O
in ADP B-O
S1 PROPN B-O
Data PROPN B-O
. PUNCT B-O

dpi PROPN B-AC
, PUNCT B-O
days NOUN B-LF
postinoculation NOUN I-LF
; PUNCT B-O
N NOUN B-O
- PUNCT B-O
acetylneuraminic NOUN B-O
acid NOUN B-O
; PUNCT B-O
siaT PROPN B-AC
, PUNCT B-O
predicted VERB B-LF
sialic ADJ I-LF
acid NOUN I-LF
transporter NOUN I-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
type NOUN I-LF
. PUNCT B-O

CFA PROPN B-AC
, PUNCT B-O
complete ADJ B-LF
Freund PROPN I-LF
’s PART I-LF
adjuvant NOUN I-LF
; PUNCT B-O
DAPI PROPN B-AC
, PUNCT B-O
4′,6 NUM B-LF
- PUNCT I-LF
diamidino-2 NOUN I-LF
- PUNCT I-LF
phenylindole NOUN I-LF
; PUNCT B-O
DRG PROPN B-AC
, PUNCT B-O
dorsal ADJ B-LF
root NOUN I-LF
ganglia NOUN I-LF
; PUNCT B-O
EV PROPN B-AC
, PUNCT B-O
empty ADJ B-LF
vector NOUN I-LF
; PUNCT B-O
GFAP PROPN B-AC
, PUNCT B-O
glial ADJ B-LF
fibrillary ADJ I-LF
acidic ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
HSV PROPN B-AC
, PUNCT B-O
herpes NOUN B-LF
simplex NOUN I-LF
virus NOUN I-LF
; PUNCT B-O
Iba1 PROPN B-AC
, PUNCT B-O
ionized VERB B-LF
calcium NOUN I-LF
binding VERB I-LF
adaptor NOUN I-LF
molecule NOUN I-LF
1 NUM I-LF
; PUNCT B-O
MM PROPN B-AC
, PUNCT B-O
mismatch NOUN B-LF
ODN PROPN I-LF
-ODNODN PROPN B-AC
; PUNCT B-O
NF200 PROPN B-O
, PUNCT B-O
neurofilament NOUN B-O
200 NUM B-O
; PUNCT B-O
ODN PROPN B-AC
, PUNCT B-O
oligodeoxynucleotide NOUN B-LF
; PUNCT B-O
SC PROPN B-AC
, PUNCT B-O
spinal ADJ B-LF
cord NOUN I-LF
; PUNCT B-O
SEM PROPN B-AC
, PUNCT B-O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
CHD PROPN B-AC
, PUNCT B-O
coronary ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
; PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
OR PROPN B-AC
, PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
, PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
. PUNCT B-O

Primaquine PROPN B-LF
( PUNCT B-O
PQ PROPN B-AC
) PUNCT B-O
actively ADV B-O
clears VERB B-O
mature ADJ B-O
Plasmodium PROPN B-O
falciparum NOUN B-O
gametocytes NOUN B-O
but CCONJ B-O
in ADP B-O
glucose-6 NOUN B-O
- PUNCT B-O
phosphate NOUN B-O
dehydrogenase NOUN B-O
deficient ADJ B-O
( PUNCT B-O
G6PDd NOUN B-O
) PUNCT B-O
individuals NOUN B-O
can AUX B-O
cause VERB B-O
hemolysis NOUN B-O
. PUNCT B-O

Further ADV B-O
, PUNCT B-O
how SCONJ B-O
much ADJ B-O
effect NOUN B-O
variations NOUN B-O
in ADP B-O
r PROPN B-AC
have AUX B-O
on ADP B-O
the DET B-O
dynamics NOUN B-O
of ADP B-O
free ADJ B-O
virus NOUN B-O
depended VERB B-O
on ADP B-O
the DET B-O
magnitude NOUN B-O
of ADP B-O
the DET B-O
minimum ADJ B-LF
activation NOUN I-LF
rate NOUN I-LF
of ADP I-LF
latently ADV I-LF
infected VERB I-LF
cells NOUN I-LF
( PUNCT B-O
amin PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Homologous ADJ B-O
recombination NOUN B-O
can AUX B-O
also ADV B-O
have VERB B-O
a DET B-O
mutagenic ADJ B-O
outcome NOUN B-O
by ADP B-O
promoting VERB B-O
recombination NOUN B-O
between ADP B-O
nonallelic ADJ B-O
repeated VERB B-O
sequences NOUN B-O
, PUNCT B-O
leading VERB B-O
to PART B-O
genomic ADJ B-O
instability NOUN B-O
, PUNCT B-O
or CCONJ B-O
by ADP B-O
templating VERB B-O
repair VERB B-O
from ADP B-O
a DET B-O
homolog NOUN B-O
rather ADV B-O
than ADP B-O
a DET B-O
sister NOUN B-O
chromatid NOUN B-O
, PUNCT B-O
leading VERB B-O
to PART B-O
loss NOUN B-LF
of ADP I-LF
heterozygosity NOUN I-LF
( PUNCT B-O
LOH PROPN B-AC
) PUNCT B-O
. PUNCT B-O

In ADP B-O
a DET B-O
living VERB B-O
cell NOUN B-O
, PUNCT B-O
multiple ADJ B-O
pathways NOUN B-O
compete VERB B-O
to PART B-O
repair VERB B-O
the DET B-O
same ADJ B-O
kinds NOUN B-O
of ADP B-O
damage NOUN B-O
. PUNCT B-O

The DET B-O
exact ADJ B-O
location NOUN B-O
of ADP B-O
Swt1 PROPN B-O
could AUX B-O
not PART B-O
be AUX B-O
determined VERB B-O
, PUNCT B-O
however ADV B-O
, PUNCT B-O
because SCONJ B-O
the DET B-O
abundance NOUN B-O
of ADP B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
( PUNCT B-O
GFP)- PROPN B-AC
or CCONJ B-O
immuno ADJ B-O
- PUNCT B-O
labeled VERB B-O
Swt1 PROPN B-O
expressed VERB B-O
from ADP B-O
the DET B-O
endogenous ADJ B-O
promoter NOUN B-O
was AUX B-O
too ADV B-O
low ADJ B-O
to PART B-O
be AUX B-O
visualized VERB B-O
( PUNCT B-O
unpublished ADJ B-O
data NOUN B-O
and CCONJ B-O
[ X B-O
18 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

While SCONJ B-O
initiation NOUN B-O
requires VERB B-O
a DET B-O
rapid ADJ B-O
but CCONJ B-O
temporary ADJ B-O
disappearance NOUN B-O
of ADP B-O
Nrg1 PROPN B-O
via ADP B-O
activation NOUN B-O
of ADP B-O
the DET B-O
cAMP NOUN B-O
- PUNCT B-O
dependent ADJ B-O
protein NOUN B-O
kinase NOUN B-O
A NOUN B-O
pathway NOUN B-O
, PUNCT B-O
maintenance NOUN B-O
requires VERB B-O
the DET B-O
recruitment NOUN B-O
to ADP B-O
promoters NOUN B-O
of ADP B-O
the DET B-O
Hda1 NOUN B-O
histone NOUN B-O
deacetylase NOUN B-O
under ADP B-O
conditions NOUN B-O
of ADP B-O
reduced VERB B-O
signaling NOUN B-O
by ADP B-O
the DET B-O
target NOUN B-LF
of ADP I-LF
rapamycin NOUN I-LF
( PUNCT B-O
TOR PROPN B-AC
) PUNCT B-O
kinase NOUN B-O
, PUNCT B-O
leading VERB B-O
to ADP B-O
chromatin NOUN B-O
remodeling NOUN B-O
that PRON B-O
blocks VERB B-O
Nrg1 PROPN B-O
access NOUN B-O
to ADP B-O
the DET B-O
promoters NOUN B-O
of ADP B-O
hypha NOUN B-O
- PUNCT B-O
specific ADJ B-O
genes NOUN B-O
. PUNCT B-O

Recent ADJ B-O
studies NOUN B-O
have AUX B-O
suggested VERB B-O
that SCONJ B-O
these DET B-O
diseases NOUN B-O
are AUX B-O
but ADV B-O
one NUM B-O
unique ADJ B-O
set NOUN B-O
of ADP B-O
immunoglobulin NOUN B-LF
- PUNCT I-LF
E NOUN I-LF
( PUNCT B-O
IgE)-mediated PROPN B-AC
allergic ADJ B-O
conditions NOUN B-O
, PUNCT B-O
linked VERB B-O
by ADP B-O
the DET B-O
common ADJ B-O
thread NOUN B-O
of ADP B-O
“ PUNCT B-O
atopic PROPN B-O
march PROPN B-O
” PUNCT B-O
[ PUNCT B-O
9 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbr PROPN B-O
. PUNCT B-O

: PUNCT B-O
AN PROPN B-AC
– PUNCT B-O
antennal ADJ B-LF
nerve NOUN I-LF
; PUNCT B-O
CDM PROPN B-AC
– PUNCT B-O
cibarial NOUN B-O
dilator NOUN B-O
muscle NOUN B-O
; PUNCT B-O
CNS PROPN B-AC
– PUNCT B-O
central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
. PUNCT B-O

Strains NOUN B-O
: PUNCT B-O
DLY12943 PROPN B-O
, PUNCT B-O
DLY7593 PROPN B-O
( PUNCT B-O
B NOUN B-O
- NOUN B-O
D NOUN B-O
) PUNCT B-O
, PUNCT B-O
DLY22883 PROPN B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
, PUNCT B-O
DLY22928 PROPN B-O
( PUNCT B-O
F NOUN B-O
) PUNCT B-O
. PUNCT B-O

GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
KS PROPN B-O
, PUNCT B-O
Kolmogorov PROPN B-O
– PUNCT B-O
Smirnov PROPN B-O
; PUNCT B-O
MAT PROPN B-AC
, PUNCT B-O
mating NOUN B-LF
type NOUN I-LF
; PUNCT B-O
MFα1 PROPN B-AC
, PUNCT B-O
major ADJ B-LF
α PUNCT I-LF
- NOUN I-LF
factor NOUN I-LF
gene NOUN I-LF
1 NUM I-LF
; PUNCT B-O
sf PROPN B-AC
, PUNCT B-O
superfolder NOUN B-LF
; PUNCT B-O
TEF1 PROPN B-AC
, PUNCT B-O
translation NOUN B-LF
elongation NOUN I-LF
factor NOUN I-LF
1 NUM I-LF
. PUNCT B-O

The DET B-O
Hopkins PROPN B-LF
Symptom PROPN I-LF
Checklist-37 PROPN I-LF
for ADP I-LF
Adolescents PROPN I-LF
( PUNCT B-O
HSCL-37A PROPN B-AC
; PUNCT B-O
[ PUNCT B-O
48 NUM B-O
] PUNCT B-O
) PUNCT B-O
examines VERB B-O
both CCONJ B-O
internalizing VERB B-O
symptoms NOUN B-O
such ADJ B-O
as ADP B-O
depression NOUN B-O
and CCONJ B-O
anxiety NOUN B-O
, PUNCT B-O
and CCONJ B-O
externalizing VERB B-O
symptoms NOUN B-O
. PUNCT B-O

These DET B-O
studies NOUN B-O
also ADV B-O
demonstrated VERB B-O
variation NOUN B-O
in ADP B-O
transmission NOUN B-O
potential NOUN B-O
after ADP B-O
different ADJ B-O
ACTs PROPN B-AC
, PUNCT B-O
with ADP B-O
artemether NOUN B-LF
- PUNCT I-LF
lumefantrine NOUN I-LF
( PUNCT B-O
AL PROPN B-AC
) PUNCT B-O
being AUX B-O
associated VERB B-O
with ADP B-O
lower ADJ B-O
post ADJ B-O
- PUNCT B-O
treatment ADJ B-O
gametocyte ADJ B-O
carriage NOUN B-O
and CCONJ B-O
transmission NOUN B-O
potential NOUN B-O
compared VERB B-O
to ADP B-O
dihydroartemisinin NOUN B-LF
- PUNCT I-LF
piperaquine NOUN I-LF
( PUNCT B-O
DP PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
12 NUM B-O
, PUNCT B-O
13 NUM B-O
] PUNCT B-O
. PUNCT B-O

Alternating VERB B-O
phase NOUN B-O
radiofrequency NOUN B-LF
( PUNCT B-O
RF PROPN B-AC
) PUNCT B-O
pulse NOUN B-O
acquisition NOUN B-O
technique NOUN B-O
implying VERB B-O
the DET B-O
acquisition NOUN B-O
of ADP B-O
multiple ADJ B-O
images NOUN B-O
, PUNCT B-O
has AUX B-O
been AUX B-O
combined VERB B-O
with ADP B-O
the DET B-O
maximum ADJ B-O
- PUNCT B-O
intensity NOUN B-O
, PUNCT B-O
the DET B-O
complex ADJ B-O
- PUNCT B-O
sum NOUN B-O
, PUNCT B-O
the DET B-O
magnitude NOUN B-O
- PUNCT B-O
sum NOUN B-O
combinations NOUN B-O
to PART B-O
eliminate VERB B-O
them PRON B-O
. PUNCT B-O

Common ADJ B-O
bacterial ADJ B-O
pathogens NOUN B-O
such ADJ B-O
as ADP B-O
Salmonella PROPN B-O
, PUNCT B-O
Shigella PROPN B-O
, PUNCT B-O
and CCONJ B-O
Yersinia PROPN B-O
spp NOUN B-O
. PUNCT B-O

invade VERB B-O
the DET B-O
gut NOUN B-O
epithelial ADJ B-O
barrier NOUN B-O
, PUNCT B-O
preferentially ADV B-O
by ADP B-O
targeting VERB B-O
the DET B-O
relatively ADV B-O
small ADJ B-O
number NOUN B-O
of ADP B-O
M NOUN B-O
cells NOUN B-O
located VERB B-O
in ADP B-O
the DET B-O
follicle NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
epithelium NOUN I-LF
( PUNCT B-O
FAE PROPN B-AC
) PUNCT B-O
[ X B-O
1–3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Data NOUN B-O
were AUX B-O
collected VERB B-O
from ADP B-O
articles NOUN B-O
published VERB B-O
in ADP B-O
2019 NUM B-O
in ADP B-O
the DET B-O
biomedical ADJ B-O
sciences NOUN B-O
journals NOUN B-O
: PUNCT B-O
British PROPN B-LF
Journal PROPN I-LF
of ADP I-LF
Pharmacology PROPN I-LF
( PUNCT B-O
BJP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Journal PROPN B-LF
of ADP I-LF
Pharmacy PROPN I-LF
and CCONJ I-LF
Pharmacology PROPN I-LF
( PUNCT B-O
JPP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Frontiers PROPN B-LF
in ADP I-LF
Pharmacology PROPN I-LF
( PUNCT B-O
FP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Journal PROPN B-LF
of ADP I-LF
Cell PROPN I-LF
Biology PROPN I-LF
( PUNCT B-O
JCB PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Journal PROPN B-LF
of ADP I-LF
Cell PROPN I-LF
Science PROPN I-LF
( PUNCT B-O
JCS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Cells PROPN B-LF
( PUNCT B-O
CEL PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Journal PROPN B-LF
of ADP I-LF
Biological PROPN I-LF
Chemistry PROPN I-LF
( PUNCT B-O
JBC PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Proceedings PROPN B-LF
of ADP I-LF
the DET I-LF
National PROPN I-LF
Academy PROPN I-LF
of ADP I-LF
Sciences PROPN I-LF
( PUNCT B-O
PNAS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

N NOUN B-O
= SYM B-O
200 NUM B-O
articles NOUN B-O
analyzed VERB B-O
in ADP B-O
each DET B-O
scientific ADJ B-O
journal NOUN B-O
. PUNCT B-O

The DET B-O
24 NUM B-O
studies NOUN B-O
that PRON B-O
contributed VERB B-O
data NOUN B-O
on ADP B-O
the DET B-O
diagnosis NOUN B-O
and CCONJ B-O
treatment NOUN B-O
practices NOUN B-O
of ADP B-O
healthcare NOUN B-O
providers NOUN B-O
were AUX B-O
undertaken VERB B-O
in ADP B-O
ten NUM B-O
countries NOUN B-O
, PUNCT B-O
involving VERB B-O
a DET B-O
range NOUN B-O
of ADP B-O
cadres NOUN B-O
, PUNCT B-O
including VERB B-O
medical ADJ B-O
doctors NOUN B-O
and CCONJ B-O
nurses NOUN B-O
, PUNCT B-O
pharmacists NOUN B-O
, PUNCT B-O
drug NOUN B-O
vendors NOUN B-O
, PUNCT B-O
traditional ADJ B-LF
birth NOUN I-LF
attendants NOUN I-LF
( PUNCT B-O
TBAs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
community NOUN B-LF
health NOUN I-LF
workers NOUN I-LF
( PUNCT B-O
CHWs PROPN B-AC
) PUNCT B-O
( PUNCT B-O
Tables NOUN B-O
2 NUM B-O
and CCONJ B-O
3 NUM B-O
) PUNCT B-O
. PUNCT B-O

fFN PROPN B-AC
, PUNCT B-O
fetal ADJ B-LF
fibronectin NOUN I-LF
; PUNCT B-O
IPD PROPN B-AC
, PUNCT B-O
individual ADJ B-LF
participant NOUN I-LF
data NOUN I-LF
; PUNCT B-O
IQR PROPN B-O
, PUNCT B-O
interquartile ADJ B-O
range NOUN B-O
; PUNCT B-O
SD NOUN B-O
, PUNCT B-O
standard ADJ B-O
deviation NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
ITH PROPN B-AC
, PUNCT B-O
intra ADJ B-LF
- ADJ I-LF
tumour ADJ I-LF
heterogeneity NOUN I-LF
; PUNCT B-O
DNAm PROPN B-AC
, PUNCT B-O
DNA NOUN B-LF
methylation NOUN I-LF
; PUNCT B-O
OC PROPN B-AC
, PUNCT B-O
ovarian ADJ B-LF
cancer NOUN I-LF
; PUNCT B-O
UCEC PROPN B-AC
, PUNCT B-O
uterine ADJ B-LF
corpus NOUN I-LF
endometrial ADJ I-LF
carcinoma NOUN I-LF
; PUNCT B-O
BRCA PROPN B-AC
, PUNCT B-O
breast NOUN B-LF
cancer NOUN I-LF
invasive ADJ I-LF
carcinoma NOUN I-LF
. PUNCT B-O

Also ADV B-O
, PUNCT B-O
F→ PROPN B-AC
, PUNCT B-O
dv1→ NOUN B-O
, PUNCT B-O
dΩ PROPN B-AC
and CCONJ B-O
σ PROPN B-AC
are AUX B-O
external ADJ B-O
force NOUN B-O
vector NOUN B-O
, PUNCT B-O
molecules NOUN B-O
of ADP B-O
class NOUN B-O
with ADP B-O
velocity NOUN B-O
v1 NOUN B-O
, PUNCT B-O
elementary ADJ B-LF
solid ADJ I-LF
angle NOUN I-LF
and CCONJ B-O
collision NOUN B-LF
cross NOUN I-LF
section NOUN I-LF
[ X B-O
5,6 NUM B-O
] PUNCT B-O
. PUNCT B-O

RNA NOUN B-O
was AUX B-O
extracted VERB B-O
from ADP B-O
liver NOUN B-O
using VERB B-O
TRIzol PROPN B-O
reagent NOUN B-O
( PUNCT B-O
Life PROPN B-O
Technologies PROPN B-O
, PUNCT B-O
Carlsbad PROPN B-O
, PUNCT B-O
CA PROPN B-O
) PUNCT B-O
and CCONJ B-O
purified VERB B-O
using VERB B-O
the DET B-O
RNeasy PROPN B-O
kit NOUN B-O
( PUNCT B-O
Qiagen PROPN B-O
, PUNCT B-O
Valencia PROPN B-O
, PUNCT B-O
CA PROPN B-O
) PUNCT B-O
. PUNCT B-O

RNA NOUN B-O
integrity NOUN B-O
was AUX B-O
verified VERB B-O
by ADP B-O
formaldehyde NOUN B-O
gel NOUN B-O
electrophoresis NOUN B-O
. PUNCT B-O

cDNA NOUN B-O
was AUX B-O
synthesized VERB B-O
using VERB B-O
iScript PROPN B-O
( PUNCT B-O
BioRad PROPN B-O
, PUNCT B-O
Hercules PROPN B-O
, PUNCT B-O
CA PROPN B-O
) PUNCT B-O
; PUNCT B-O
quantitative ADJ B-LF
PCR NOUN I-LF
( PUNCT B-O
qPCR PROPN B-AC
) PUNCT B-O
was AUX B-O
performed VERB B-O
with ADP B-O
TaqMan PROPN B-O
® PROPN B-O
assay NOUN B-O
kits NOUN B-O
( PUNCT B-O
Life PROPN B-O
Technologies PROPN B-O
, PUNCT B-O
Carlsbad PROPN B-O
, PUNCT B-O
CA PROPN B-O
) PUNCT B-O
using VERB B-O
β PUNCT B-O
- NOUN B-O
glucuronidase NOUN B-O
as ADP B-O
the DET B-O
internal ADJ B-O
control NOUN B-O
gene NOUN B-O
. PUNCT B-O

Previous ADJ B-O
studies NOUN B-O
have AUX B-O
implicated VERB B-O
that SCONJ B-O
prolonged VERB B-O
activation NOUN B-O
( PUNCT B-O
> PUNCT B-O
10 NUM B-O
min NOUN B-O
) PUNCT B-O
of ADP B-O
mGluR1/5 NOUN B-O
by ADP B-O
DHPG PROPN B-AC
can AUX B-O
stimulate VERB B-O
spinal ADJ B-O
excitatory ADJ B-O
interneurons NOUN B-O
to PART B-O
produce VERB B-O
endocannabinoids NOUN B-O
, PUNCT B-O
which PRON B-O
act VERB B-O
as ADP B-O
retrograde ADJ B-O
messengers NOUN B-O
to PART B-O
stimulate VERB B-O
Type-1 NOUN B-LF
cannabinoid NOUN I-LF
( PUNCT B-O
CB1 PROPN B-AC
) PUNCT B-O
receptors NOUN B-O
expressed VERB B-O
at ADP B-O
inhibitory ADJ B-O
nerve NOUN B-O
terminals NOUN B-O
[ PUNCT B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

Some DET B-O
TUNEL+ NOUN B-O
cells NOUN B-O
are AUX B-O
also ADV B-O
detected VERB B-O
in ADP B-O
the DET B-O
mantle NOUN B-O
zone NOUN B-O
of ADP B-O
the DET B-O
PSB PROPN B-AC
in ADP B-O
mutant ADJ B-O
embryos NOUN B-O
( PUNCT B-O
Div PROPN B-O
) PUNCT B-O
but CCONJ B-O
do AUX B-O
not PART B-O
correspond VERB B-O
to ADP B-O
CR PROPN B-AC
cells NOUN B-O
since SCONJ B-O
no DET B-O
loss NOUN B-O
of ADP B-O
Reln PROPN B-O
was AUX B-O
observed VERB B-O
in ADP B-O
the DET B-O
lateral ADJ B-LF
pallium NOUN B-O
. PUNCT B-O

( PUNCT B-O
E NOUN B-O
– PUNCT B-O
H NOUN B-O
) PUNCT B-O
Immunofluorescence NOUN B-O
using VERB B-O
Dbx1 NOUN B-O
antisera NOUN B-O
showing VERB B-O
that SCONJ B-O
at ADP B-O
the DET B-O
septum ADJ B-O
dorsal ADJ B-O
Dbx1 NOUN B-O
+ NOUN B-O
cells NOUN B-O
are AUX B-O
deleted VERB B-O
in ADP B-O
mutant ADJ B-O
embryos NOUN B-O
( PUNCT B-O
F NOUN B-O
) PUNCT B-O
compared VERB B-O
to ADP B-O
control NOUN B-O
animals NOUN B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
whereas SCONJ B-O
ventral ADJ B-O
Dbx1 NOUN B-O
+ NOUN B-O
cells NOUN B-O
are AUX B-O
not PART B-O
( PUNCT B-O
compare VERB B-O
G PROPN B-O
and CCONJ B-O
H NOUN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
situ ADJ B-O
hybridization NOUN B-O
for ADP B-O
Reln PROPN B-O
( PUNCT B-O
I NOUN B-O
, PUNCT B-O
K NOUN B-O
, PUNCT B-O
quantified VERB B-O
in ADP B-O
M PROPN B-O
) PUNCT B-O
and CCONJ B-O
p73 NOUN B-O
( PUNCT B-O
J PROPN B-O
, PUNCT B-O
L PROPN B-AC
, PUNCT B-O
quantified VERB B-O
in ADP B-O
N PROPN B-O
) PUNCT B-O
at ADP B-O
caudal ADJ B-O
levels NOUN B-O
shows VERB B-O
that SCONJ B-O
there PRON B-O
is VERB B-O
no DET B-O
significant ADJ B-O
difference NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
6 NUM B-O
) PUNCT B-O
in ADP B-O
the DET B-O
numbers NOUN B-O
of ADP B-O
Reln+ NOUN B-O
and CCONJ B-O
p73 NOUN B-O
+ NOUN B-O
cells NOUN B-O
between ADP B-O
E11.5 NUM B-O
control NOUN B-O
( PUNCT B-O
I NOUN B-O
and CCONJ B-O
J PROPN B-O
) PUNCT B-O
and CCONJ B-O
Dbx1DTA;Emx1iresCre PROPN B-O
embryos NOUN B-O
( PUNCT B-O
K NOUN B-O
and CCONJ B-O
L PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Quantifications NOUN B-O
of ADP B-O
the DET B-O
numbers NOUN B-O
of ADP B-O
Reln+ NOUN B-O
and CCONJ B-O
p73 NOUN B-O
+ NOUN B-O
cells NOUN B-O
in ADP B-O
L1 NOUN B-O
( PUNCT B-O
O NOUN B-O
) PUNCT B-O
and CCONJ B-O
L2 NOUN B-O
( PUNCT B-O
P NOUN B-O
) PUNCT B-O
DM PROPN B-AC
regions NOUN B-O
of ADP B-O
E12.5 NUM B-O
control NOUN B-O
( PUNCT B-O
white ADJ B-O
bars NOUN B-O
) PUNCT B-O
and CCONJ B-O
Dbx1DTA;Emx1iresCre PROPN B-O
embryos NOUN B-O
( PUNCT B-O
black ADJ B-O
bars NOUN B-O
) PUNCT B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
3 NUM B-O
) PUNCT B-O
. PUNCT B-O

* PUNCT B-O
P<0.05 NUM B-O
. PUNCT B-O

CoSMO PROPN B-AC
, PUNCT B-O
Cooperation NOUN B-LF
that PRON I-LF
is AUX I-LF
Synthetic ADJ I-LF
and CCONJ I-LF
Mutually ADV I-LF
Obligatory ADJ I-LF
. PUNCT B-O

Propensity NOUN B-O
- PUNCT B-O
score NOUN B-O
- PUNCT B-O
matched VERB B-O
controls NOUN B-O
were AUX B-O
selected VERB B-O
from ADP B-O
9,246 NUM B-O
non ADJ B-O
- PUNCT B-O
SAMI PROPN B-AC
patients NOUN B-O
( PUNCT B-O
non ADJ B-O
- PUNCT B-O
SA PROPN B-AC
- PUNCT B-O
MI PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
association NOUN B-O
of ADP B-O
SA PROPN B-AC
and CCONJ B-O
outcomes NOUN B-O
including VERB B-O
all DET B-O
- PUNCT B-O
cause NOUN B-O
mortality NOUN B-O
and CCONJ B-O
major ADJ B-LF
adverse ADJ I-LF
cardiac ADJ I-LF
and CCONJ I-LF
cerebrovascular ADJ I-LF
events NOUN I-LF
( PUNCT B-O
MACCEs PROPN B-AC
) PUNCT B-O
were AUX B-O
analyzed VERB B-O
by ADP B-O
a DET B-O
Cox PROPN B-O
proportional ADJ B-O
hazards NOUN B-O
model NOUN B-O
. PUNCT B-O

AMBA PROPN B-O
, PUNCT B-O
Allen PROPN B-O
Mouse PROPN B-O
Brain PROPN B-O
Atlas PROPN B-O
; PUNCT B-O
CE PROPN B-O
, PUNCT B-O
cerebellum NOUN B-O
; PUNCT B-O
Fndc5 PROPN B-O
, PUNCT B-O
fibronectin NOUN B-O
type NOUN B-O
III NUM B-O
domain NOUN B-O
containing VERB B-O
5 NUM B-O
; PUNCT B-O
HB PROPN B-O
, PUNCT B-O
hindbrain NOUN B-O
; PUNCT B-O
LAV PROPN B-O
, PUNCT B-O
lateral ADJ B-O
vestibular ADJ B-O
nucleus NOUN B-O
; PUNCT B-O
LC PROPN B-O
, PUNCT B-O
locus NOUN B-O
coeruleus NOUN B-O
; PUNCT B-O
MV PROPN B-O
, PUNCT B-O
medial ADJ B-O
vestibular ADJ B-O
nucleus NOUN B-O
; PUNCT B-O
OT PROPN B-O
, PUNCT B-O
optic ADJ B-O
tectum NOUN B-O
; PUNCT B-O
P56 PROPN B-O
, PUNCT B-O
postnatal ADJ B-O
day NOUN B-O
56 NUM B-O
; PUNCT B-O
Pp NOUN B-O
, PUNCT B-O
prepontine ADJ B-O
area NOUN B-O
; PUNCT B-O
SUV PROPN B-AC
, PUNCT B-O
superior ADJ B-LF
vestibular ADJ I-LF
nucleus NOUN I-LF
; PUNCT B-O
TH NOUN B-O
, PUNCT B-O
tyrosine NOUN B-O
hydroxylase NOUN B-O
; PUNCT B-O
ZBB PROPN B-AC
, PUNCT B-O
Zebrafish PROPN B-LF
Brain PROPN I-LF
Browser PROPN I-LF
. PUNCT B-O

Descending VERB B-LF
DAD- PROPN B-AC
aortic ADJ I-LF
distensibility NOUN I-LF
. PUNCT B-O

The DET B-O
present ADJ B-O
findings NOUN B-O
of ADP B-O
an DET B-O
association NOUN B-O
between ADP B-O
recent ADJ B-O
cannabis NOUN B-O
use NOUN B-O
and CCONJ B-O
psychotic ADJ B-O
features NOUN B-O
are AUX B-O
consistent ADJ B-O
with ADP B-O
reports NOUN B-O
of ADP B-O
cannabis NOUN B-O
creating VERB B-O
an DET B-O
acute ADJ B-O
toxic ADJ B-O
psychosis NOUN B-O
and CCONJ B-O
with ADP B-O
short ADJ B-O
- PUNCT B-O
duration NOUN B-O
effects NOUN B-O
in ADP B-O
laboratory NOUN B-O
studies NOUN B-O
of ADP B-O
high ADJ B-O
doses NOUN B-O
of ADP B-O
intravenous ADJ B-O
tetrahydrocannabinol NOUN B-LF
( PUNCT B-O
THC PROPN B-AC
) PUNCT B-O
in ADP B-O
35%–50 NUM B-O
% NOUN B-O
of ADP B-O
healthy ADJ B-O
participants NOUN B-O
[ PUNCT B-O
17,60,61 NUM B-O
] PUNCT B-O
. PUNCT B-O

This PRON B-O
overlaps VERB B-O
the DET B-O
values NOUN B-O
for ADP B-O
the DET B-O
mammalian ADJ B-O
stratum NOUN B-O
4 NUM B-O
and CCONJ B-O
3 NUM B-O
genes NOUN B-O
( PUNCT B-O
mean ADJ B-O
K NOUN B-O
s NOUN B-O
values NOUN B-O
8 NUM B-O
% NOUN B-O
and CCONJ B-O
30 NUM B-O
% NOUN B-O
, PUNCT B-O
respectively ADV B-O
) PUNCT B-O
; PUNCT B-O
these DET B-O
strata NOUN B-O
are AUX B-O
inferred VERB B-O
to PART B-O
have AUX B-O
ceased VERB B-O
recombining VERB B-O
between ADP B-O
the DET B-O
X NOUN B-O
and CCONJ B-O
Y NOUN B-O
30–50 NUM B-O
million NUM B-LF
years NOUN I-LF
ago ADV I-LF
( PUNCT B-O
MYA PROPN B-AC
) PUNCT B-O
for ADP B-O
stratum NOUN B-O
4 NUM B-O
, PUNCT B-O
and CCONJ B-O
80–130 NUM B-O
MYA PROPN B-AC
for ADP B-O
stratum NOUN B-O
3 NUM B-O
, PUNCT B-O
whereas SCONJ B-O
strata NOUN B-O
1 NUM B-O
and CCONJ B-O
2 NUM B-O
diverged VERB B-O
130–320 NUM B-O
MYA PROPN B-AC
[ PUNCT B-O
9,11 NUM B-O
] PUNCT B-O
. PUNCT B-O

ChIP PROPN B-AC
, PUNCT B-O
chromatin NOUN B-LF
immunoprecipitation NOUN I-LF
and CCONJ I-LF
sequencing NOUN I-LF
; PUNCT B-O
-SeqdnIκBα PROPN B-AC
, PUNCT B-O
dominant ADJ B-O
negative ADJ B-O
mutated VERB B-O
IκBα PROPN B-O
; PUNCT B-O
FDR PROPN B-AC
, PUNCT B-O
false ADJ B-LF
discovery NOUN I-LF
rate NOUN I-LF
; PUNCT B-O
GEO PROPN B-O
, PUNCT B-O
Gene PROPN B-O
Expression PROPN B-O
Omnibus PROPN B-O
; PUNCT B-O
hnRNP NOUN B-O
, PUNCT B-O
heterogeneous ADJ B-O
nuclear ADJ B-O
ribonucleoprotein NOUN B-O
; PUNCT B-O
IκBα PROPN B-O
, PUNCT B-O
NFKB PROPN B-O
inhibitor NOUN B-O
alpha NOUN B-O
; PUNCT B-O
NC PROPN B-O
, PUNCT B-O
nitrocellulose NOUN B-O
; PUNCT B-O
NF PROPN B-AC
, PUNCT B-O
nuclear ADJ B-LF
factor NOUN I-LF
kappa NOUN I-LF
B NOUN I-LF
; PUNCT B-O
-κBP+I PROPN B-AC
, PUNCT B-O
phorbol NOUN B-O
12 NUM B-O
- PUNCT B-O
myristate NOUN B-O
13 NUM B-O
- PUNCT B-O
acetate NOUN B-O
and CCONJ B-O
ionomycin NOUN B-O
; PUNCT B-O
RNA PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT B-O
-SeqTet PROPN B-AC
, PUNCT B-O
tetracycline NOUN B-LF
. PUNCT B-O

The DET B-O
concerted ADJ B-O
action NOUN B-O
of ADP B-O
the DET B-O
three NUM B-O
HIV-1 PROPN B-O
proteins NOUN B-O
Nef PROPN B-O
, PUNCT B-O
Env PROPN B-O
, PUNCT B-O
and CCONJ B-O
Vpu PROPN B-O
results VERB B-O
in ADP B-O
a DET B-O
complete ADJ B-O
removal NOUN B-O
of ADP B-O
CD4 NOUN B-O
from ADP B-O
the DET B-O
surface NOUN B-O
of ADP B-O
HIV PROPN B-O
infected VERB B-O
cells NOUN B-O
through ADP B-O
( PUNCT B-O
i X B-O
) PUNCT B-O
enhanced VERB B-O
routing NOUN B-O
of ADP B-O
CD4 NOUN B-O
to ADP B-O
the DET B-O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT B-O
ER PROPN B-AC
) PUNCT B-O
degradation NOUN B-O
pathway NOUN B-O
[ PUNCT B-O
12],[13 X B-O
] PUNCT B-O
and CCONJ B-O
( PUNCT B-O
ii X B-O
) PUNCT B-O
activated VERB B-O
endocytosis NOUN B-O
and CCONJ B-O
lysosomal ADJ B-O
degradation NOUN B-O
[ PUNCT B-O
14],[15 X B-O
] PUNCT B-O
. PUNCT B-O

Morphologic ADJ B-O
parameters NOUN B-O
collected VERB B-O
by ADP B-O
USG PROPN B-AC
, PUNCT B-O
such ADJ B-O
as ADP B-O
cross ADJ B-LF
- ADJ I-LF
sectional ADJ I-LF
area NOUN I-LF
( PUNCT B-O
CSA PROPN B-AC
) PUNCT B-O
obtained VERB B-O
from ADP B-O
transverse ADJ B-O
scans NOUN B-O
, PUNCT B-O
provide VERB B-O
useful ADJ B-O
information NOUN B-O
complementary ADJ B-O
to ADP B-O
electrophysiological ADJ B-O
data NOUN B-O
[ PUNCT B-O
11–13 NUM B-O
] PUNCT B-O
. PUNCT B-O

TNAP PROPN B-AC
dephosphorylates VERB B-O
poly NOUN B-O
- PUNCT B-O
inosine NOUN B-O
: PUNCT B-O
cytosine NOUN B-O
( PUNCT B-O
Toll PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
( PUNCT B-O
TLR PROPN B-AC
) PUNCT B-O
3 NUM B-O
agonist NOUN B-O
) PUNCT B-O
and CCONJ B-O
LPS PROPN B-AC
from ADP B-O
Klebsiella PROPN B-O
pneumoniae NOUN B-O
and CCONJ B-O
Salmonella PROPN B-O
minnesota PROPN B-O
( PUNCT B-O
TLR4 PROPN B-O
agonists NOUN B-O
) PUNCT B-O
. PUNCT B-O

HPLC PROPN B-AC
analysis NOUN B-O
was AUX B-O
carried VERB B-O
out ADP B-O
using VERB B-O
an DET B-O
Agilent PROPN B-O
1260 NUM B-O
Infinity PROPN B-O
system NOUN B-O
( PUNCT B-O
Agilent PROPN B-O
Technologies PROPN B-O
) PUNCT B-O
with ADP B-O
ultraviolet NOUN B-LF
( PUNCT B-O
UV PROPN B-AC
) PUNCT B-O
detection NOUN B-O
at ADP B-O
278 NUM B-O
nm NOUN B-O
( PUNCT B-O
maximum ADJ B-O
absorbance NOUN B-O
of ADP B-O
Cm PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
44 NUM B-O
] PUNCT B-O
. PUNCT B-O

GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
; PUNCT B-O
PS PROPN B-AC
, PUNCT B-O
phosphatidylserine NOUN B-LF
; PUNCT B-O
UAS PROPN B-AC
, PUNCT B-O
upstream ADJ B-LF
activating VERB I-LF
sequence NOUN I-LF
. PUNCT B-O

Among ADP B-O
urban ADJ B-O
, PUNCT B-O
migrant NOUN B-O
, PUNCT B-O
and CCONJ B-O
rural ADJ B-O
men NOUN B-O
the DET B-O
age- NOUN B-O
and CCONJ B-O
factory NOUN B-O
- PUNCT B-O
adjusted VERB B-O
percentages NOUN B-O
classified VERB B-O
as ADP B-O
obese ADJ B-O
( PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
[ X B-O
BMI PROPN B-AC
] X B-O
> NUM B-O
25 NUM B-O
kg NOUN B-O
/ SYM B-O
m2 NOUN B-O
) PUNCT B-O
were AUX B-O
41.9 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
[ X B-O
CI PROPN B-AC
] X B-O
39.1–44.7 NUM B-O
) PUNCT B-O
, PUNCT B-O
37.8 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
35.0–40.6 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
19.0 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
17.0–21.0 NUM B-O
) PUNCT B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
and CCONJ B-O
as ADP B-O
diabetic ADJ B-O
were AUX B-O
13.5 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
11.6–15.4 NUM B-O
) PUNCT B-O
, PUNCT B-O
14.3 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
12.2–16.4 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
6.2 NUM B-O
% NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
5.0–7.4 NUM B-O
) PUNCT B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O

Viruses NOUN B-O
cause VERB B-O
respiratory ADJ B-LF
tract NOUN I-LF
infections NOUN I-LF
( PUNCT B-O
RTIs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
if SCONJ B-O
severe ADJ B-O
, PUNCT B-O
can AUX B-O
lead VERB B-O
to ADP B-O
a DET B-O
visit NOUN B-O
to ADP B-O
the DET B-O
Emergency PROPN B-LF
Department PROPN I-LF
( PUNCT B-O
ED PROPN B-AC
) PUNCT B-O
and CCONJ B-O
hospitalization NOUN B-O
. PUNCT B-O

MDA PROPN B-AC
, PUNCT B-O
mass PROPN B-LF
drug PROPN I-LF
administration NOUN I-LF
; PUNCT B-O
IRS PROPN B-AC
, PUNCT B-O
indoor ADJ B-LF
residual NOUN I-LF
spraying NOUN I-LF
; PUNCT B-O
rfMDA PROPN B-AC
, PUNCT B-O
reactive ADJ B-LF
focal ADJ I-LF
mass PROPN B-LF
drug PROPN I-LF
administration NOUN I-LF
; PUNCT B-O
LLIN PROPN B-AC
, PUNCT B-O
long ADJ B-LF
lasting ADJ I-LF
insecticidal ADJ I-LF
nets NOUN I-LF
; PUNCT B-O
NMCP PROPN B-AC
, PUNCT B-O
national ADJ B-O
malaria NOUN B-O
control NOUN B-O
programme NOUN B-O
; PUNCT B-O
Contr PROPN B-O
, PUNCT B-O
contribution NOUN B-O
; PUNCT B-O
Ref PROPN B-O
, PUNCT B-O
reference NOUN B-O
. PUNCT B-O

Exploring VERB B-O
potential ADJ B-O
subgroup NOUN B-O
effects NOUN B-O
of ADP B-O
maternal ADJ B-O
age NOUN B-O
, PUNCT B-O
parity NOUN B-O
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
fetal ADJ B-O
sex NOUN B-O
is AUX B-O
therefore ADV B-O
impossible ADJ B-O
in ADP B-O
individual ADJ B-O
trials NOUN B-O
. PUNCT B-O

This DET B-O
process NOUN B-O
can AUX B-O
be AUX B-O
accomplished VERB B-O
by ADP B-O
alternative ADJ B-O
precursor NOUN B-LF
messenger NOUN I-LF
RNA NOUN I-LF
( PUNCT B-O
pre-mRNA PROPN B-AC
) PUNCT B-O
splicing NOUN B-O
. PUNCT B-O

CIN PROPN B-AC
, PUNCT B-O
cervical ADJ B-LF
intraepithelial ADJ I-LF
neoplasia NOUN I-LF
. PUNCT B-O

De X B-O
novo X B-O
pathogenic ADJ B-O
variants NOUN B-O
in ADP B-O
Histone NOUN B-LF
- NOUN I-LF
lysine NOUN I-LF
N NOUN I-LF
- NOUN I-LF
methyltransferase NOUN I-LF
2D PROPN I-LF
( PUNCT B-O
KMT2D PROPN B-AC
) PUNCT B-O
are AUX B-O
causative ADJ B-O
in ADP B-O
up ADP B-O
to PART B-O
76 NUM B-O
% NOUN B-O
of ADP B-O
KS PROPN B-O
patients NOUN B-O
[ PUNCT B-O
18,19 NUM B-O
] PUNCT B-O
. PUNCT B-O

* PUNCT B-O
Reproductive ADJ B-O
/ SYM B-O
antenatal ADJ B-O
health NOUN B-O
: PUNCT B-O
Reproductive ADJ B-O
/ SYM B-O
antenatal ADJ B-O
knowledge NOUN B-O
, PUNCT B-O
medical ADJ B-O
abortion NOUN B-O
, PUNCT B-O
facility NOUN B-O
delivery NOUN B-O
, PUNCT B-O
child NOUN B-O
dietary ADJ B-O
diversity NOUN B-O
. PUNCT B-O

†Non ADJ B-O
- ADJ I-LF
communicable ADJ I-LF
diseases NOUN I-LF
: PUNCT B-O
Diabetes NOUN B-O
, PUNCT B-O
hypertension NOUN B-O
. PUNCT B-O

‡One NUM B-O
ongoing ADJ B-O
NCD PROPN B-AC
trial NOUN B-O
is AUX B-O
a DET B-O
multicenter NOUN B-O
study NOUN B-O
in ADP B-O
South PROPN B-O
Africa PROPN B-O
and CCONJ B-O
Malawi PROPN B-O
, PUNCT B-O
hence ADV B-O
the DET B-O
number NOUN B-O
of ADP B-O
symbols NOUN B-O
exceeds VERB B-O
the DET B-O
number NOUN B-O
of ADP B-O
included VERB B-O
trials NOUN B-O
by ADP B-O
one NUM B-O
. PUNCT B-O

§ PUNCT B-O
Map NOUN B-O
developed VERB B-O
by ADP B-O
use NOUN B-O
of ADP B-O
mapchart.net NOUN B-O
. PUNCT B-O

Phase NOUN B-O
contrast NOUN B-O
cine NOUN B-O
gradient NOUN B-O
echo NOUN B-O
sequence NOUN B-O
was AUX B-O
also ADV B-O
obtained VERB B-O
to PART B-O
evaluate VERB B-O
aortic ADJ B-O
stiffness NOUN B-O
including VERB B-O
ascending VERB B-O
and CCONJ B-O
descending ADJ B-LF
aortic ADJ I-LF
distensibility NOUN I-LF
( PUNCT B-O
AAD NOUN B-O
and CCONJ B-O
DAD PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
pulse NOUN B-LF
wave NOUN I-LF
velocity NOUN I-LF
( PUNCT B-O
PWV PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

Streptokinase PROPN B-O
was AUX B-O
administered VERB B-O
in ADP B-O
seven NUM B-O
( PUNCT B-O
6.3 NUM B-O
% NOUN B-O
) NOUN B-O
patients NOUN B-O
with ADP B-O
STEMI PROPN B-AC
. PUNCT B-O

Primary ADJ B-O
percutaneous ADJ B-LF
coronary ADJ I-LF
intervention NOUN I-LF
( PUNCT B-O
PCI PROPN B-AC
) NOUN B-O
was AUX B-O
done VERB B-O
in ADP B-O
six NUM B-O
( PUNCT B-O
3.9 NUM B-O
% NOUN B-O
) NOUN B-O
patients NOUN B-O
with ADP B-O
STEMI PROPN B-AC
. PUNCT B-O

Loading VERB B-O
dose NOUN B-O
of ADP B-O
aspirin NOUN B-O
and CCONJ B-O
clopidogrel NOUN B-O
were AUX B-O
administered VERB B-O
in ADP B-O
the DET B-O
emergency NOUN B-O
setting NOUN B-O
in ADP B-O
about ADV B-O
63.8 NUM B-O
% NOUN B-O
and CCONJ B-O
62.8 NUM B-O
% NOUN B-O
of ADP B-O
patients NOUN B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O

Overall ADJ B-O
and CCONJ B-O
age NOUN B-O
- ADJ B-O
specific ADJ B-O
meta ADJ B-O
- ADJ B-O
analytic ADJ B-O
estimates NOUN B-O
of ADP B-O
proportion NOUN B-O
positive ADJ B-O
were AUX B-O
multiplied VERB B-O
by ADP B-O
LRI PROPN B-AC
hospitalization NOUN B-O
and CCONJ B-O
LRI PROPN B-AC
episode NOUN B-O
estimates NOUN B-O
for ADP B-O
adults NOUN B-O
≥20 NUM B-O
years NOUN B-O
, PUNCT B-O
which PRON B-O
were AUX B-O
from ADP B-O
the DET B-O
Global PROPN B-LF
Burden PROPN I-LF
of ADP I-LF
Disease PROPN I-LF
( PUNCT B-O
GBD PROPN B-AC
) PUNCT B-O
2017 NUM B-O
study NOUN B-O
[ PUNCT B-O
10 NUM B-O
] PUNCT B-O
, PUNCT B-O
obtained VERB B-O
for ADP B-O
calendar NOUN B-O
year NOUN B-O
2016 NUM B-O
for ADP B-O
this DET B-O
analysis NOUN B-O
. PUNCT B-O

cART PROPN B-AC
, PUNCT B-O
combined ADJ B-O
antiretroviral ADJ B-O
therapy NOUN B-O
; PUNCT B-O
CI PROPN B-O
, PUNCT B-O
confidence NOUN B-O
interval NOUN B-O
; PUNCT B-O
DTG PROPN B-AC
, PUNCT B-O
dolutegravir NOUN B-LF
; PUNCT B-O
FTC PROPN B-AC
, PUNCT B-O
emtricitabine NOUN B-LF
; PUNCT B-O
ITT PROPN B-AC
, PUNCT B-O
intention NOUN B-LF
- PUNCT I-LF
to PART I-LF
- PUNCT I-LF
treat VERB I-LF
; PUNCT B-O
PP PROPN B-AC
, PUNCT B-O
per ADP B-O
- PUNCT B-O
protocol NOUN B-O
. PUNCT B-O

People NOUN B-O
with ADP B-O
mental ADJ B-O
illnesses NOUN B-O
: PUNCT B-O
Patients NOUN B-O
under ADP B-O
psychiatric ADJ B-O
medications NOUN B-O
for ADP B-O
mental ADJ B-O
illnesses NOUN B-O
whose DET B-O
identity NOUN B-O
were AUX B-O
informed VERB B-O
by ADP B-O
Female PROPN B-LF
Community PROPN I-LF
Health PROPN I-LF
Volunteers PROPN I-LF
( PUNCT B-O
FCHVs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
PHC PROPN B-AC
health NOUN B-O
workers NOUN B-O
or CCONJ B-O
secondary ADJ B-O
health NOUN B-O
service NOUN B-O
providers NOUN B-O
. PUNCT B-O

Wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
( PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
CD45.1 NOUN B-O
and CCONJ B-O
CD45.2 NOUN B-O
mice NOUN B-O
were AUX B-O
bred VERB B-O
and CCONJ B-O
maintained VERB B-O
in ADP B-O
conventional ADJ B-O
pathogen NOUN B-O
- PUNCT B-O
free ADJ B-O
colonies NOUN B-O
at ADP B-O
either CCONJ B-O
the DET B-O
National PROPN B-O
Institute PROPN B-O
for ADP B-O
Medical PROPN B-O
Research PROPN B-O
( PUNCT B-O
London PROPN B-O
, PUNCT B-O
United PROPN B-O
Kingdom PROPN B-O
) PUNCT B-O
or CCONJ B-O
at ADP B-O
the DET B-O
Royal PROPN B-O
Free PROPN B-O
Campus PROPN B-O
of ADP B-O
University PROPN B-O
College PROPN B-O
London PROPN B-O
. PUNCT B-O

We PRON B-O
undertook VERB B-O
meta NOUN B-O
- PUNCT B-O
analyses NOUN B-O
using VERB B-O
RevMan PROPN B-O
5.3 NUM B-O
[ X B-O
30 NUM B-O
] X B-O
using VERB B-O
random ADJ B-O
- PUNCT B-O
effects NOUN B-O
models NOUN B-O
and CCONJ B-O
calculated VERB B-O
relative ADJ B-LF
risks NOUN I-LF
( PUNCT B-O
RRs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
mean ADJ B-LF
differences NOUN I-LF
( PUNCT B-O
MDs PROPN B-AC
) PUNCT B-O
with ADP B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT B-O
CIs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

To PART B-O
quantify VERB B-O
time NOUN B-O
- PUNCT B-O
dependent ADJ B-O
changes NOUN B-O
in ADP B-O
synaptic ADJ B-O
gain NOUN B-O
we PRON B-O
used VERB B-O
an DET B-O
“ PUNCT B-O
Adaptation PROPN B-LF
Index PROPN I-LF
” PUNCT B-O
( PUNCT B-O
AI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
calculated VERB B-O
as ADP B-O
the DET B-O
ratio NOUN B-O
between ADP B-O
the DET B-O
peak ADJ B-O
initial ADJ B-O
response NOUN B-O
to ADP B-O
an DET B-O
increase NOUN B-O
in ADP B-O
contrast NOUN B-O
and CCONJ B-O
the DET B-O
later ADJ B-O
steady ADJ B-O
- PUNCT B-O
state NOUN B-O
response NOUN B-O
. PUNCT B-O

During ADP B-O
the DET B-O
course NOUN B-O
of ADP B-O
this DET B-O
study NOUN B-O
, PUNCT B-O
an DET B-O
updated VERB B-O
, PUNCT B-O
larger ADJ B-O
GWAS PROPN B-AC
dataset NOUN B-O
for ADP B-O
coronary ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
CAD PROPN B-AC
) PUNCT B-O
became VERB B-O
publicly ADV B-O
available ADJ B-O
( PUNCT B-O
CARDIoGRAMplusC4D PROPN B-O
Consortium PROPN B-O
, PUNCT B-O
release NOUN B-O
2015 NUM B-O
[ X B-O
41 NUM B-O
] PUNCT B-O
) PUNCT B-O
; PUNCT B-O
we PRON B-O
therefore ADV B-O
redid VERB B-O
the DET B-O
analysis NOUN B-O
for ADP B-O
CAD PROPN B-AC
using VERB B-O
the DET B-O
release NOUN B-O
2015 NUM B-O
data NOUN B-O
. PUNCT B-O

Rate NOUN B-O
ratio NOUN B-O
( PUNCT B-O
RR NOUN B-O
) PUNCT B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
credible ADJ B-LF
interval NOUN I-LF
( PUNCT B-O
CrI PROPN B-AC
) PUNCT B-O
in ADP B-O
brackets NOUN B-O
, PUNCT B-O
significant ADJ B-O
predictions NOUN B-O
in ADP B-O
bold NOUN B-O
. PUNCT B-O

To PART B-O
analyze VERB B-O
the DET B-O
amount NOUN B-O
of ADP B-O
asymmetry NOUN B-O
between ADP B-O
the DET B-O
dominant ADJ B-O
and CCONJ B-O
non ADJ B-O
- ADJ B-O
dominant ADJ B-O
lower ADJ B-O
limbs NOUN B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
the DET B-O
absolute ADJ B-LF
symmetry NOUN I-LF
index NOUN I-LF
( PUNCT B-O
ASI PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
symmetry NOUN B-LF
index NOUN I-LF
( PUNCT B-O
SI PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
31–34 NUM B-O
] PUNCT B-O
. PUNCT B-O

This DET B-O
method NOUN B-O
, PUNCT B-O
called VERB B-O
optimal ADJ B-LF
metabolic ADJ I-LF
network NOUN I-LF
identification NOUN I-LF
( PUNCT B-O
OMNI PROPN B-AC
) PUNCT B-O
, PUNCT B-O
allows VERB B-O
efficient ADJ B-O
identification NOUN B-O
of ADP B-O
the DET B-O
set NOUN B-O
of ADP B-O
reactions NOUN B-O
that PRON B-O
results VERB B-O
in ADP B-O
the DET B-O
best ADJ B-O
agreement NOUN B-O
between ADP B-O
in ADP B-O
silico NOUN B-O
predicted VERB B-O
and CCONJ B-O
experimentally ADV B-O
measured VERB B-O
flux NOUN B-O
distributions NOUN B-O
. PUNCT B-O

We PRON B-O
then ADV B-O
removed VERB B-O
any DET B-O
variants NOUN B-O
with ADP B-O
flags NOUN B-O
“ PUNCT B-O
badRead ADJ B-O
, PUNCT B-O
” PUNCT B-O
mapping NOUN B-LF
quality NOUN I-LF
( PUNCT B-O
“ PUNCT B-O
MQ PROPN B-AC
” PUNCT B-O
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
quality NOUN B-LF
depth NOUN I-LF
( PUNCT B-O
“ PUNCT B-O
QD PROPN B-AC
” PUNCT B-O
) PUNCT B-O
. PUNCT B-O

After ADP B-O
fixation NOUN B-O
and CCONJ B-O
permeabilization NOUN B-O
, PUNCT B-O
the DET B-O
cells NOUN B-O
were AUX B-O
stained VERB B-O
for ADP B-O
pSHIP PROPN B-AC
and CCONJ B-O
analyzed VERB B-O
using VERB B-O
confocal ADJ B-LF
microscopy NOUN I-LF
( PUNCT B-O
CFm PROPN B-AC
) PUNCT B-O
or CCONJ B-O
flow NOUN B-O
cytometry NOUN B-O
( PUNCT B-O
A NOUN B-O
, PUNCT B-O
B NOUN B-O
and CCONJ B-O
D NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
mean ADJ B-LF
fluorescence NOUN I-LF
intensity NOUN I-LF
( PUNCT B-O
MFI PROPN B-AC
) PUNCT B-O
of ADP B-O
pSHIP PROPN B-AC
was AUX B-O
generated VERB B-O
using VERB B-O
NIS PROPN B-O
- PUNCT B-O
Elements PROPN B-O
AR PROPN B-O
3.2 NUM B-O
software NOUN B-O
( PUNCT B-O
C NOUN B-O
) PUNCT B-O
. PUNCT B-O

Flow NOUN B-O
cytometry NOUN B-O
analysis NOUN B-O
of ADP B-O
the DET B-O
MFI PROPN B-AC
of ADP B-O
pSHIP PROPN B-AC
after ADP B-O
stimulation NOUN B-O
with ADP B-O
sAgs PROPN B-AC
( PUNCT B-O
D NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
Pearson PROPN B-O
’s PART B-O
correlation NOUN B-O
coefficients NOUN B-O
between ADP B-O
BCR PROPN B-AC
and CCONJ B-O
pSHIP PROPN B-AC
staining NOUN B-O
in ADP B-O
sAg PROPN B-AC
- PUNCT B-O
stimulated VERB B-O
cells NOUN B-O
were AUX B-O
determined VERB B-O
using VERB B-O
NIS PROPN B-O
- PUNCT B-O
Elements PROPN B-O
AR PROPN B-O
3.2 NUM B-O
software NOUN B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
. PUNCT B-O

Shown VERB B-O
are AUX B-O
representative ADJ B-O
images NOUN B-O
at ADP B-O
indicated VERB B-O
times NOUN B-O
and CCONJ B-O
the DET B-O
average ADJ B-O
values NOUN B-O
( PUNCT B-O
±SD NOUN B-O
) PUNCT B-O
of ADP B-O
about ADV B-O
50 NUM B-O
cells NOUN B-O
from ADP B-O
3 NUM B-O
independent ADJ B-O
experiments NOUN B-O
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
higher ADJ B-O
prevalence NOUN B-O
of ADP B-O
tumor NOUN B-LF
- PUNCT I-LF
infiltrating VERB I-LF
lymphocytes NOUN I-LF
( PUNCT B-O
TILs PROPN B-AC
) PUNCT B-O
has AUX B-O
been AUX B-O
associated VERB B-O
with ADP B-O
better ADJ B-O
prognosis NOUN B-O
[ PUNCT B-O
19–22 NUM B-O
] PUNCT B-O
, PUNCT B-O
irrespective ADV B-O
of ADP B-O
the DET B-O
chemotherapy NOUN B-O
administered VERB B-O
, PUNCT B-O
and CCONJ B-O
also ADV B-O
with ADP B-O
a DET B-O
higher ADJ B-O
rate NOUN B-O
of ADP B-O
pCR PROPN B-AC
to ADP B-O
neoadjuvant ADJ B-O
anthracycline NOUN B-O
- PUNCT B-O
based VERB B-O
chemotherapy NOUN B-O
in ADP B-O
TNBC PROPN B-AC
[ PUNCT B-O
23 NUM B-O
] PUNCT B-O
. PUNCT B-O

To PART B-O
address VERB B-O
this DET B-O
question NOUN B-O
, PUNCT B-O
hairpin NOUN B-O
RNA NOUN B-LF
- PUNCT I-LF
induced VERB I-LF
gene NOUN I-LF
silencing NOUN I-LF
( PUNCT B-O
RNAi PROPN B-AC
) PUNCT B-O
was AUX B-O
adopted VERB B-O
. PUNCT B-O

The DET B-O
first ADJ B-O
antimetabolite NOUN B-O
drug NOUN B-O
that PRON B-O
was AUX B-O
developed VERB B-O
to PART B-O
specifically ADV B-O
target VERB B-O
cancer NOUN B-O
cells NOUN B-O
was AUX B-O
the DET B-O
pyrimidine NOUN B-O
analogue NOUN B-O
5 NUM B-LF
- PUNCT I-LF
fluorouracil NOUN I-LF
, PUNCT B-O
5-FU PROPN B-AC
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

5 PROPN B-AC
targets VERB B-O
several ADJ B-O
cellular ADJ B-O
mechanisms NOUN B-O
through ADP B-O
its PRON B-O
activated VERB B-O
metabolites NOUN B-O
FdUMP NOUN B-O
, PUNCT B-O
FUTP PROPN B-O
and CCONJ B-O
FdUTP NOUN B-O
[ PUNCT B-O
2–3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Cb PROPN B-O
, PUNCT B-O
Coxiella PROPN B-O
burnetii NOUN B-O
; PUNCT B-O
GO PROPN B-AC
, PUNCT B-O
Gene PROPN B-LF
Ontology NOUN I-LF
; PUNCT B-O
praw NOUN B-O
, PUNCT B-O
original ADJ B-O
p NOUN B-O
- PUNCT B-O
value NOUN B-O
; PUNCT B-O
padj NOUN B-O
, PUNCT B-O
adjusted VERB B-O
p NOUN B-O
- PUNCT B-O
value NOUN B-O
according VERB B-O
to ADP B-O
the DET B-O
Benjamini PROPN B-O
- PUNCT B-O
Hochberg PROPN B-O
multiple ADJ B-O
test NOUN B-O
correction NOUN B-O
[ PUNCT B-O
43 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
conceptus NOUN B-O
was AUX B-O
dissected VERB B-O
, PUNCT B-O
and CCONJ B-O
transcriptome NOUN B-O
data NOUN B-O
were AUX B-O
generated VERB B-O
for ADP B-O
extraembryonic ADJ B-O
tissue NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
the DET B-O
endometrium NOUN B-O
was AUX B-O
dissected VERB B-O
into ADP B-O
caruncular ADJ B-O
( PUNCT B-O
gland NOUN B-O
- PUNCT B-O
free ADJ B-O
) PUNCT B-O
and CCONJ B-O
intercaruncular ADJ B-O
( PUNCT B-O
containing VERB B-O
endometrial ADJ B-O
glands NOUN B-O
) PUNCT B-O
areas NOUN B-O
, PUNCT B-O
and CCONJ B-O
transcriptome NOUN B-O
data NOUN B-O
were AUX B-O
generated VERB B-O
from ADP B-O
both DET B-O
regions NOUN B-O
of ADP B-O
the DET B-O
endometrium NOUN B-O
( PUNCT B-O
Fig NOUN B-O
1A NUM B-O
) PUNCT B-O
. PUNCT B-O

Therefore ADV B-O
, PUNCT B-O
the DET B-O
data NOUN B-O
set NOUN B-O
analyzed VERB B-O
was AUX B-O
comprised VERB B-O
of ADP B-O
three NUM B-O
sample NOUN B-O
types NOUN B-O
collected VERB B-O
from ADP B-O
each DET B-O
pregnancy NOUN B-O
: PUNCT B-O
extraembryonic ADJ B-O
, PUNCT B-O
caruncular ADJ B-O
, PUNCT B-O
and CCONJ B-O
intercaruncular ADJ B-O
tissues NOUN B-O
( PUNCT B-O
Fig NOUN B-O
1B NUM B-O
) PUNCT B-O
. PUNCT B-O

Alignment NOUN B-O
of ADP B-O
the DET B-O
sequences NOUN B-O
to ADP B-O
the DET B-O
B. PROPN B-O
taurus PROPN B-O
genome NOUN B-O
( PUNCT B-O
University PROPN B-LF
of ADP I-LF
Maryland PROPN I-LF
[ X B-O
UMD PROPN B-AC
] X B-O
assembly NOUN B-O
3.1 NUM B-O
) PUNCT B-O
resulted VERB B-O
into ADP B-O
an DET B-O
average NOUN B-O
of ADP B-O
22 NUM B-O
, PUNCT B-O
31.4 NUM B-O
, PUNCT B-O
and CCONJ B-O
34.6 NUM B-O
million NUM B-O
uniquely ADV B-O
mapped VERB B-O
reads NOUN B-O
for ADP B-O
extraembryonic ADJ B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
5 NUM B-O
) PUNCT B-O
, PUNCT B-O
caruncular ADJ B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
5 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
intercaruncular ADJ B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
5 NUM B-O
) PUNCT B-O
tissues NOUN B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O

Hormone NOUN B-LF
therapy NOUN I-LF
( PUNCT B-O
HT PROPN B-AC
) PUNCT B-O
may AUX B-O
decrease VERB B-O
the DET B-O
risk NOUN B-O
of ADP B-O
osteoporosis NOUN B-O
and CCONJ B-O
bone NOUN B-O
fracture NOUN B-O
[ PUNCT B-O
31 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
review NOUN B-O
is AUX B-O
reported VERB B-O
according VERB B-O
to ADP B-O
the DET B-O
Preferred ADJ B-LF
Reporting PROPN I-LF
Items PROPN I-LF
for ADP I-LF
Systematic PROPN I-LF
Reviews PROPN I-LF
and CCONJ I-LF
Meta PROPN I-LF
- PROPN I-LF
Analyses PROPN I-LF
( PUNCT B-O
PRISMA PROPN B-AC
) PUNCT B-O
[ X B-O
19 X B-O
] PUNCT B-O
( PUNCT B-O
see VERB B-O
S1 PROPN B-O
Checklist PROPN B-O
) PUNCT B-O
and CCONJ B-O
the DET B-O
Guidelines PROPN B-O
for ADP B-O
Meta PROPN B-O
- PROPN B-O
Analyses PROPN B-O
and CCONJ B-O
Systematic PROPN B-O
Reviews PROPN B-O
of ADP B-O
Observational PROPN B-O
Studies.[20 PROPN B-O
] PUNCT B-O
The DET B-O
protocol NOUN B-O
was AUX B-O
published VERB B-O
in ADP B-O
advance NOUN B-O
( PUNCT B-O
ID NOUN B-O
= X B-O
CRD42015025488).[21 NUM B-O
] PUNCT B-O
Eligibility NOUN B-O
criteria NOUN B-O
were AUX B-O
defined VERB B-O
in ADP B-O
relation NOUN B-O
to ADP B-O
PICOS PROPN B-AC
( PUNCT B-O
participants NOUN B-LF
, PUNCT I-LF
interventions NOUN I-LF
, PUNCT I-LF
comparisons NOUN I-LF
, PUNCT I-LF
outcomes NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
study NOUN I-LF
design NOUN I-LF
) PUNCT B-O
as SCONJ B-O
recommended VERB B-O
by ADP B-O
PRISMA PROPN B-AC
. PUNCT B-O

In ADP B-O
this DET B-O
study NOUN B-O
, PUNCT B-O
we PRON B-O
assembled VERB B-O
a DET B-O
large ADJ B-O
array NOUN B-O
of ADP B-O
variables NOUN B-O
from ADP B-O
4 NUM B-O
components NOUN B-O
within ADP B-O
HRS PROPN B-AC
, PUNCT B-O
including VERB B-O
the DET B-O
core NOUN B-O
survey NOUN B-O
( PUNCT B-O
1996–2016 NUM B-O
) PUNCT B-O
, PUNCT B-O
the DET B-O
newly ADV B-O
released VERB B-O
2015 NUM B-O
Life PROPN B-LF
History PROPN I-LF
Mail PROPN I-LF
Survey PROPN I-LF
( PUNCT B-O
LHMS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
Enhanced PROPN B-LF
Face PROPN I-LF
- PUNCT I-LF
To ADP I-LF
- PUNCT I-LF
Face PROPN I-LF
( PUNCT B-O
EFTF PROPN B-AC
) PUNCT B-O
interview NOUN B-O
( PUNCT B-O
2006–2016 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
2016 NUM B-O
Venous PROPN B-LF
Blood PROPN I-LF
Study PROPN I-LF
( PUNCT B-O
VBS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

A DET B-O
description NOUN B-O
of ADP B-O
the DET B-O
4 NUM B-O
data NOUN B-O
sources NOUN B-O
can AUX B-O
be AUX B-O
found VERB B-O
in ADP B-O
S1 PROPN B-O
Appendix PROPN B-O
and CCONJ B-O
elsewhere ADV B-O
[ PUNCT B-O
31 NUM B-O
] PUNCT B-O
. PUNCT B-O

A DET B-O
plot NOUN B-O
of ADP B-O
the DET B-O
total ADJ B-O
median ADJ B-LF
p-Stat5 PROPN B-AC
fluorescence NOUN I-LF
intensity NOUN I-LF
( PUNCT B-O
MFI PROPN B-AC
) PUNCT B-O
versus ADP B-O
Epo PROPN B-AC
concentration NOUN B-O
has VERB B-O
Michaelian ADJ B-O
kinetics NOUN B-O
with ADP B-O
a DET B-O
Hill PROPN B-LF
coefficient NOUN I-LF
( PUNCT B-O
nH PROPN B-AC
) PUNCT B-O
of ADP B-O
1 NUM B-O
( PUNCT B-O
lower ADJ B-O
left ADJ B-O
panel NOUN B-O
, PUNCT B-O
please INTJ B-O
note VERB B-O
a DET B-O
log NOUN B-O
scale NOUN B-O
was AUX B-O
used VERB B-O
for ADP B-O
the DET B-O
x NOUN B-O
- NOUN B-O
axis NOUN B-O
) PUNCT B-O
. PUNCT B-O

A X B-O
: PUNCT B-O
Flow NOUN B-O
cytometry NOUN B-O
of ADP B-O
patient ADJ B-O
P3 NOUN B-O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT B-O
PBMC PROPN B-AC
) PUNCT B-O
( PUNCT B-O
left ADJ B-O
column NOUN B-O
) PUNCT B-O
followed VERB B-O
by ADP B-O
cell NOUN B-O
sorting NOUN B-O
of ADP B-O
TCRVβ22 NOUN B-O
+ ADJ B-O
tumor NOUN B-O
cells NOUN B-O
( PUNCT B-O
median ADJ B-O
column NOUN B-O
) PUNCT B-O
and CCONJ B-O
non ADJ B-O
- ADJ B-O
TCRVβ22 NOUN B-O
+ ADJ B-O
cells NOUN B-O
( PUNCT B-O
right ADJ B-O
column NOUN B-O
) PUNCT B-O
. PUNCT B-O

STAT2 PROPN B-O
is AUX B-O
the DET B-O
quintessential ADJ B-O
transcription NOUN B-O
factor NOUN B-O
for ADP B-O
type NOUN B-O
1 NUM B-O
interferons NOUN B-LF
( PUNCT B-O
IFNs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
where SCONJ B-O
it PRON B-O
functions VERB B-O
as ADP B-O
a DET B-O
heterodimer NOUN B-O
with ADP B-O
STAT1 PROPN B-O
. PUNCT B-O

However ADV B-O
, PUNCT B-O
the DET B-O
human ADJ B-O
and CCONJ B-O
murine ADJ B-O
STAT2 PROPN B-O
- PUNCT B-O
deficient ADJ B-O
phenotypes NOUN B-O
suggest VERB B-O
important ADJ B-O
additional ADJ B-O
and CCONJ B-O
currently ADV B-O
unidentified ADJ B-O
type NOUN B-O
1 NUM B-O
IFN PROPN B-AC
- PUNCT B-O
independent ADJ B-O
activities NOUN B-O
. PUNCT B-O

We PRON B-O
performed VERB B-O
the DET B-O
present ADJ B-O
exclusive ADJ B-O
study NOUN B-O
to PART B-O
investigate VERB B-O
the DET B-O
associations NOUN B-O
between ADP B-O
a DET B-O
total NOUN B-O
of ADP B-O
9 NUM B-O
static ADJ B-O
and CCONJ B-O
14 NUM B-O
dynamic ADJ B-O
lactate NOUN B-O
indices NOUN B-O
during ADP B-O
the DET B-O
first ADJ B-O
24h NUM B-O
of ADP B-O
an DET B-O
intensive ADJ B-LF
care NOUN I-LF
unit NOUN I-LF
( PUNCT B-O
ICU PROPN B-AC
) PUNCT B-O
and CCONJ B-O
in ADP B-O
- PUNCT B-O
hospital NOUN B-O
mortality NOUN B-O
in ADP B-O
unselected ADJ B-O
ICU PROPN B-AC
patients NOUN B-O
. PUNCT B-O

Since SCONJ B-O
selective ADJ B-O
serotonin NOUN B-O
reuptake NOUN B-O
inhibitors NOUN B-O
( PUNCT B-O
SSRIs PROPN B-O
) PUNCT B-O
such ADJ B-O
as ADP B-O
fluvoxamine NOUN B-O
and CCONJ B-O
sertraline NOUN B-O
are AUX B-O
potent ADJ B-O
σ1R NOUN B-O
ligands NOUN B-O
, PUNCT B-O
we PRON B-O
recently ADV B-O
focused VERB B-O
on ADP B-O
cardioprotective ADJ B-O
mechanisms NOUN B-O
of ADP B-O
SSRI PROPN B-O
through ADP B-O
the DET B-O
σ1R NOUN B-O
in ADP B-O
heart NOUN B-O
failure NOUN B-O
models NOUN B-O
using VERB B-O
transverse ADJ B-LF
aortic ADJ I-LF
constriction NOUN I-LF
( PUNCT B-O
TAC PROPN B-AC
) PUNCT B-O
mice NOUN B-O
and CCONJ B-O
ovariectomised ADJ B-O
rats NOUN B-O
[ PUNCT B-O
5–7 NUM B-O
] PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
unilateral ADJ B-O
and CCONJ B-O
bilateral ADJ B-O
reversible ADJ B-O
inactivation NOUN B-O
of ADP B-O
the DET B-O
frontal ADJ B-LF
eye NOUN I-LF
fields NOUN I-LF
( PUNCT B-O
FEF PROPN B-AC
) PUNCT B-O
to PART B-O
identify VERB B-O
a DET B-O
cortical ADJ B-O
drive NOUN B-O
for ADP B-O
microsaccades NOUN B-O
. PUNCT B-O

Ten NUM B-O
- PUNCT B-O
week NOUN B-O
- PUNCT B-O
old ADJ B-O
C57BL/6 PROPN B-O
male ADJ B-O
mice NOUN B-O
( PUNCT B-O
purchased VERB B-O
from ADP B-O
Taconic PROPN B-O
, PUNCT B-O
Ry PROPN B-O
, PUNCT B-O
Denmark PROPN B-O
, PUNCT B-O
and CCONJ B-O
allowed VERB B-O
one NUM B-O
week NOUN B-O
of ADP B-O
acclimatization NOUN B-O
on ADP B-O
chow NOUN B-O
diet NOUN B-O
before ADP B-O
study NOUN B-O
start NOUN B-O
) PUNCT B-O
were AUX B-O
fed VERB B-O
either CCONJ B-O
a DET B-O
high ADJ B-O
fat NOUN B-O
control NOUN B-O
diet NOUN B-O
( PUNCT B-O
HFD PROPN B-AC
, PUNCT B-O
n NOUN B-O
= SYM B-O
9 NUM B-O
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
a DET B-O
high ADJ B-LF
fat NOUN I-LF
diet NOUN I-LF
containing VERB B-O
0.75 NUM B-O
% NOUN B-O
TTA PROPN B-AC
( PUNCT B-O
n NOUN B-O
= SYM B-O
9 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
water NOUN B-O
ad X B-O
libitum X B-O
for ADP B-O
6 NUM B-O
weeks NOUN B-O
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
rates NOUN B-O
of ADP B-O
new ADJ B-O
hepatitis NOUN B-LF
C PROPN I-LF
virus NOUN I-LF
( PUNCT B-O
HCV PROPN B-AC
) PUNCT B-O
infection NOUN B-O
are AUX B-O
on ADP B-O
the DET B-O
rise NOUN B-O
due ADP B-O
to ADP B-O
the DET B-O
ongoing ADJ B-O
epidemic NOUN B-O
of ADP B-O
injection NOUN B-O
drug NOUN B-O
use NOUN B-O
. PUNCT B-O

It PRON B-O
was AUX B-O
found VERB B-O
that SCONJ B-O
an DET B-O
increase NOUN B-O
in ADP B-O
the DET B-O
optical ADJ B-LF
density NOUN I-LF
( PUNCT B-O
OD PROPN B-AC
) PUNCT B-O
of ADP B-O
the DET B-O
formazan NOUN B-O
dye NOUN B-O
directly ADV B-O
correlates VERB B-O
with ADP B-O
the DET B-O
metabolic ADJ B-O
activity NOUN B-O
of ADP B-O
the DET B-O
cells NOUN B-O
following VERB B-O
exposure NOUN B-O
to ADP B-O
either CCONJ B-O
Pt PROPN B-AC
or CCONJ B-O
-DissPt PROPN B-AC
. PUNCT B-O

For ADP B-O
measurement NOUN B-O
of ADP B-O
the DET B-O
formazan NOUN B-O
dye NOUN B-O
intensities NOUN B-O
, PUNCT B-O
the DET B-O
cell NOUN B-O
culture NOUN B-O
medium NOUN B-O
was AUX B-O
exchanged VERB B-O
with ADP B-O
those PRON B-O
containing VERB B-O
WST-1 NOUN B-O
solution NOUN B-O
at ADP B-O
the DET B-O
final ADJ B-O
concentration NOUN B-O
of ADP B-O
1 NUM B-O
mg NOUN B-O
/ SYM B-O
ml NOUN B-O
. PUNCT B-O

Further ADV B-O
, PUNCT B-O
1,377 NUM B-O
of ADP B-O
these DET B-O
windows NOUN B-O
overlapped VERB B-O
with ADP B-O
the DET B-O
transcription NOUN B-O
start NOUN B-O
site NOUN B-O
or CCONJ B-O
gene NOUN B-O
body NOUN B-O
of ADP B-O
766 NUM B-O
independent ADJ B-O
genes NOUN B-O
in ADP B-O
Suz12 PROPN B-AC
- PUNCT B-O
deleted VERB B-O
basal ADJ B-O
organoids NOUN B-O
( PUNCT B-O
referred VERB B-O
to ADP B-O
as ADP B-O
differentially ADV B-LF
accessible ADJ I-LF
[ X B-O
DA PROPN B-AC
] X B-O
genes NOUN B-O
from ADP B-O
hereon ADV B-O
) PUNCT B-O
. PUNCT B-O

Biopharmaceutical ADJ B-LF
products NOUN I-LF
( PUNCT B-O
BPs PROPN B-AC
) PUNCT B-O
are AUX B-O
widely ADV B-O
used VERB B-O
to PART B-O
treat VERB B-O
autoimmune ADJ B-O
diseases NOUN B-O
, PUNCT B-O
but CCONJ B-O
immunogenicity NOUN B-O
limits VERB B-O
their PRON B-O
efficacy NOUN B-O
for ADP B-O
an DET B-O
important ADJ B-O
proportion NOUN B-O
of ADP B-O
patients NOUN B-O
. PUNCT B-O

ATc PROPN B-AC
, PUNCT B-O
anhydrotetracycline NOUN B-LF
; PUNCT B-O
GCaMP6 PROPN B-AC
, PUNCT B-O
GFP NOUN B-LF
- PUNCT I-LF
GFP PROPN B-AC
Calmodulin NOUN I-LF
- PUNCT I-LF
M13 NOUN I-LF
- PUNCT I-LF
peptide-6 NOUN I-LF
. PUNCT B-O

To ADP B-O
this DET B-O
day NOUN B-O
, PUNCT B-O
vertebrate ADJ B-O
prion NOUN B-LF
proteins NOUN I-LF
exhibit VERB B-O
profound ADJ B-O
sequence NOUN B-O
similarities NOUN B-O
to ADP B-O
the DET B-O
subbranch NOUN B-O
of ADP B-O
ZIP PROPN B-O
zinc NOUN B-O
transporters NOUN B-O
comprising VERB B-O
ZIP5 NUM B-O
, PUNCT B-O
ZIP6 PROPN B-O
and CCONJ B-O
ZIP10 NOUN B-O
[ PUNCT B-O
2 NUM B-O
, PUNCT B-O
3 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
highly ADV B-O
similar ADJ B-O
defects NOUN B-O
in ADP B-O
the DET B-O
execution NOUN B-O
of ADP B-O
a DET B-O
morphogenetic ADJ B-O
program NOUN B-O
, PUNCT B-O
known VERB B-O
as ADP B-O
epithelial ADJ B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
mesenchymal ADJ I-LF
transition NOUN I-LF
( PUNCT B-O
EMT PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
, PUNCT B-O
have AUX B-O
been AUX B-O
reported VERB B-O
for ADP B-O
zebrafish NOUN B-O
embryos NOUN B-O
deficient ADJ B-O
in ADP B-O
ZIP6 PROPN B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
or CCONJ B-O
PrP PROPN B-AC
[ PUNCT B-O
6 NUM B-O
] PUNCT B-O
. PUNCT B-O

On ADP B-O
17 NUM B-O
days NOUN B-LF
of ADP I-LF
gestation NOUN I-LF
( PUNCT B-O
17-DG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
dams NOUN B-O
were AUX B-O
anesthetized VERB B-O
by ADP B-O
ketamine NOUN B-O
( PUNCT B-O
75mg NUM B-O
/ SYM B-O
kg NOUN B-O
) PUNCT B-O
and CCONJ B-O
xylazine NOUN B-O
( PUNCT B-O
10mg NUM B-O
/ SYM B-O
kg NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
uterus NOUN B-O
was AUX B-O
exposed VERB B-O
. PUNCT B-O

All DET B-O
patients NOUN B-O
with ADP B-O
IVF PROPN B-AC
received VERB B-O
an DET B-O
implantable ADJ B-LF
cardioverter ADJ I-LF
defibrillator NOUN I-LF
( PUNCT B-O
ICD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Patients NOUN B-O
took VERB B-O
oral ADJ B-O
antiarrhythmic ADJ B-O
agents NOUN B-O
during ADP B-O
the DET B-O
follow NOUN B-O
- ADJ B-O
up ADP B-O
period NOUN B-O
, PUNCT B-O
including VERB B-O
amiodarone NOUN B-O
, PUNCT B-O
flecainide NOUN B-O
, PUNCT B-O
propafenone NOUN B-O
, PUNCT B-O
beta NOUN B-O
- ADJ B-O
blockers NOUN B-O
( PUNCT B-O
BB PROPN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
calcium NOUN B-O
channel NOUN B-O
blocker NOUN B-O
( PUNCT B-O
CCB PROPN B-O
) PUNCT B-O
. PUNCT B-O

Many ADJ B-O
patients NOUN B-O
did AUX B-O
n’t PART B-O
take VERB B-O
medications NOUN B-O
and CCONJ B-O
the DET B-O
patients NOUN B-O
who PRON B-O
had AUX B-O
received VERB B-O
medication NOUN B-O
mostly ADV B-O
took VERB B-O
beta NOUN B-O
- ADJ B-O
blockers NOUN B-O
: PUNCT B-O
20 NUM B-O
patients NOUN B-O
in ADP B-O
the DET B-O
f PROPN B-AC
group NOUN B-O
[ PUNCT B-O
no DET B-O
medications NOUN B-O
( PUNCT B-O
7 NUM B-O
) PUNCT B-O
, PUNCT B-O
BB PROPN B-O
( PUNCT B-O
5 NUM B-O
) PUNCT B-O
, PUNCT B-O
CCB PROPN B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
amiodarone NOUN B-O
( PUNCT B-O
1 NUM B-O
) PUNCT B-O
, PUNCT B-O
CCB PROPN B-O
+ CCONJ B-O
BB PROPN B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
amiodarone NOUN B-O
+ CCONJ B-O
BB PROPN B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
flecanide NOUN B-O
+ CCONJ B-O
BB PROPN B-O
( PUNCT B-O
1 NUM B-O
) PUNCT B-O
] PUNCT B-O
, PUNCT B-O
35 NUM B-O
patients NOUN B-O
in ADP B-O
the DET B-O
J PROPN B-O
wave PROPN B-O
group NOUN B-O
[ PUNCT B-O
no DET B-O
medications NOUN B-O
( PUNCT B-O
15 NUM B-O
) PUNCT B-O
, PUNCT B-O
BB PROPN B-O
( PUNCT B-O
13 NUM B-O
) PUNCT B-O
, PUNCT B-O
CCB PROPN B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
amiodarone NOUN B-O
( PUNCT B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
CCB PROPN B-O
+ CCONJ B-O
BB PROPN B-O
( PUNCT B-O
1 NUM B-O
) PUNCT B-O
, PUNCT B-O
propafenone NOUN B-O
( PUNCT B-O
1 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
propafenone NOUN B-O
+ CCONJ B-O
BB PROPN B-O
( PUNCT B-O
1 NUM B-O
) PUNCT B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
26 NUM B-O
patients NOUN B-O
in ADP B-O
the DET B-O
normal ADJ B-O
-QRSECG PROPN B-AC
group NOUN B-O
[ PUNCT B-O
no DET B-O
medications NOUN B-O
( PUNCT B-O
16 NUM B-O
) PUNCT B-O
, PUNCT B-O
BB PROPN B-O
( PUNCT B-O
9 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
amiodarone NOUN B-O
( PUNCT B-O
1 NUM B-O
) PUNCT B-O
] PUNCT B-O
. PUNCT B-O

Although SCONJ B-O
adjuvant ADJ B-LF
platinum NOUN I-LF
- ADJ I-LF
based VERB I-LF
chemotherapy NOUN I-LF
( PUNCT B-O
AC PROPN B-AC
) PUNCT B-O
has AUX B-O
been AUX B-O
shown VERB B-O
to PART B-O
improve VERB B-O
survival NOUN B-O
of ADP B-O
patients NOUN B-O
with ADP B-O
completely ADV B-O
resected VERB B-O
stage NOUN B-O
II NUM B-O
and CCONJ B-O
stage NOUN B-O
IIIA NUM B-O
non ADJ B-LF
- ADJ I-LF
small ADJ I-LF
cell NOUN I-LF
lung NOUN I-LF
cancer NOUN I-LF
( PUNCT B-O
NSCLC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
its PRON B-O
effect NOUN B-O
is AUX B-O
limited ADJ B-O
. PUNCT B-O

The DET B-O
DSX PROPN B-O
transgenic ADJ B-O
line NOUN B-O
[ X B-O
12 X B-O
] X B-O
that PRON B-O
expresses VERB B-O
GFP PROPN B-AC
( PUNCT B-O
green NOUN B-O
) PUNCT B-O
under ADP B-O
the DET B-O
β PUNCT B-O
- NOUN B-O
tubulin NOUN B-O
promoter NOUN B-O
in ADP B-O
the DET B-O
meiotic ADJ B-O
stages NOUN B-O
starting VERB B-O
from ADP B-O
spermatocytes NOUN B-O
but CCONJ B-O
not PART B-O
in ADP B-O
the DET B-O
mitotic ADJ B-O
germline NOUN B-LF
stem NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
GSC PROPN B-AC
) PUNCT B-O
and CCONJ B-O
spermatogonia NOUN B-O
. PUNCT B-O

MS PROPN B-AC
, PUNCT B-O
multiple ADJ B-LF
sclerosis NOUN I-LF
; PUNCT B-O
PMD PROPN B-AC
, PUNCT B-O
postmortem ADJ B-LF
delay NOUN I-LF
. PUNCT B-O

A DET B-O
common ADJ B-O
limitation NOUN B-O
of ADP B-O
SE PROPN B-AC
recording NOUN B-O
is AUX B-O
the DET B-O
lack NOUN B-O
of ADP B-O
true ADJ B-O
monophasic ADJ B-O
shapes NOUN B-O
of ADP B-O
recorded VERB B-O
CAPs PROPN B-AC
due ADJ B-O
to ADP B-O
propagation NOUN B-O
of ADP B-O
action NOUN B-O
potentials NOUN B-O
within ADP B-O
the DET B-O
SE PROPN B-AC
portion NOUN B-O
of ADP B-O
axons NOUN B-O
, PUNCT B-O
resulting VERB B-O
in ADP B-O
different ADJ B-O
degrees NOUN B-O
of ADP B-O
biphasicity NOUN B-O
depending VERB B-O
on ADP B-O
preservation NOUN B-O
of ADP B-O
conduction NOUN B-O
properties NOUN B-O
of ADP B-O
distinct ADJ B-O
types NOUN B-O
of ADP B-O
axons NOUN B-O
within ADP B-O
the DET B-O
SE PROPN B-AC
. PUNCT B-O

As ADP B-O
in ADP B-O
any DET B-O
SE PROPN B-AC
- PUNCT B-O
recorded VERB B-O
CAPs PROPN B-AC
, PUNCT B-O
the DET B-O
signals NOUN B-O
propagating VERB B-O
within ADP B-O
the DET B-O
suction NOUN B-LF
electrode NOUN I-LF
portion NOUN B-O
of ADP B-O
axons NOUN B-O
may AUX B-O
create VERB B-O
a DET B-O
time NOUN B-O
- PUNCT B-O
shifted VERB B-O
signal NOUN B-O
of ADP B-O
opposite ADJ B-O
polarity NOUN B-O
affecting VERB B-O
the DET B-O
peaks NOUN B-O
and CCONJ B-O
valleys NOUN B-O
of ADP B-O
recorded VERB B-O
signals NOUN B-O
, PUNCT B-O
being AUX B-O
more ADV B-O
pronounced ADJ B-O
in ADP B-O
slower ADV B-O
conducting VERB B-O
components NOUN B-O
( PUNCT B-O
seen VERB B-O
to ADP B-O
different ADJ B-O
extent NOUN B-O
in ADP B-O
Figs NOUN B-O
2–9 NUM B-O
) PUNCT B-O
. PUNCT B-O

Healthcare NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
infections NOUN I-LF
( PUNCT B-O
HAIs PROPN B-AC
) PUNCT B-O
are AUX B-O
associated VERB B-O
with ADP B-O
increased VERB B-O
morbidity NOUN B-O
and CCONJ B-O
mortality NOUN B-O
and CCONJ B-O
excess ADJ B-O
costs NOUN B-O
, PUNCT B-O
and CCONJ B-O
because SCONJ B-O
a DET B-O
significant ADJ B-O
proportion NOUN B-O
of ADP B-O
them PRON B-O
are AUX B-O
preventable ADJ B-O
, PUNCT B-O
they PRON B-O
are AUX B-O
considered VERB B-O
to PART B-O
be AUX B-O
a DET B-O
marker NOUN B-O
of ADP B-O
quality NOUN B-O
of ADP B-O
patient NOUN B-O
care NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Randomised ADJ B-LF
controlled VERB I-LF
trials NOUN I-LF
( PUNCT B-O
RCTs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
longitudinal ADJ B-O
cohort NOUN B-O
, PUNCT B-O
and CCONJ B-O
cross ADJ B-O
- ADJ B-O
sectional ADJ B-O
studies NOUN B-O
were AUX B-O
considered VERB B-O
for ADP B-O
inclusion NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
retrospective ADJ B-O
registry NOUN B-O
reviews NOUN B-O
, PUNCT B-O
medical ADJ B-O
records NOUN B-O
audits NOUN B-O
, PUNCT B-O
and CCONJ B-O
qualitative ADJ B-O
studies NOUN B-O
were AUX B-O
excluded VERB B-O
. PUNCT B-O

These DET B-O
results NOUN B-O
are AUX B-O
not PART B-O
from ADP B-O
data NOUN B-O
collected VERB B-O
in ADP B-O
a DET B-O
centralised ADJ B-O
laboratory NOUN B-O
, PUNCT B-O
and CCONJ B-O
different ADJ B-O
multiplex NOUN B-O
polymerase NOUN B-LF
chain NOUN I-LF
reaction NOUN I-LF
( PUNCT B-O
PCR PROPN B-AC
) PUNCT B-O
panels NOUN B-O
for ADP B-O
detecting VERB B-O
viruses NOUN B-O
were AUX B-O
used VERB B-O
in ADP B-O
the DET B-O
respective ADJ B-O
laboratories NOUN B-O
[ PUNCT B-O
19 NUM B-O
] PUNCT B-O
. PUNCT B-O

Open ADJ B-LF
access NOUN I-LF
( PUNCT B-O
OA PROPN B-AC
) PUNCT B-O
to ADP B-O
the DET B-O
scientific ADJ B-O
literature NOUN B-O
means VERB B-O
the DET B-O
removal NOUN B-O
of ADP B-O
barriers NOUN B-O
( PUNCT B-O
including VERB B-O
price NOUN B-O
barriers NOUN B-O
) PUNCT B-O
from ADP B-O
accessing VERB B-O
scholarly ADJ B-O
work NOUN B-O
. PUNCT B-O

f X B-O
- X B-O
forward NOUN B-O
; PUNCT B-O
r NOUN B-O
- X B-O
reverse NOUN B-O
; PUNCT B-O
Ta NOUN B-O
– PUNCT B-O
Annealing NOUN B-O
temperature NOUN B-O
, PUNCT B-O
RE- NOUN B-O
restriction NOUN B-O
Enzyme PROPN B-O
, PUNCT B-O
AS PROPN B-AC
- X B-O
Allele PROPN B-LF
Specific PROPN I-LF
Ref PROPN B-O
- X B-O
reference NOUN B-O
We PRON B-O
also ADV B-O
collected VERB B-O
measures NOUN B-O
of ADP B-O
inhibitory ADJ B-O
control NOUN B-O
and CCONJ B-O
working VERB B-O
memory NOUN B-O
using VERB B-O
the DET B-O
pencil NOUN B-LF
tapping NOUN I-LF
task NOUN I-LF
( PUNCT B-O
PTT PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
29 X B-O
] PUNCT B-O
and CCONJ B-O
of ADP B-O
pre ADJ B-O
- PUNCT B-O
academic ADJ B-O
skills NOUN B-O
using VERB B-O
a DET B-O
subset NOUN B-O
of ADP B-O
age NOUN B-O
- PUNCT B-O
appropriate ADJ B-O
items NOUN B-O
from ADP B-O
the DET B-O
Daberon PROPN B-LF
Screening PROPN I-LF
for ADP I-LF
School PROPN I-LF
Readiness PROPN I-LF
– PUNCT I-LF
Second PROPN I-LF
Edition PROPN I-LF
( PUNCT B-O
Daberon-2 PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
30 NUM B-O
] PUNCT B-O
. PUNCT B-O

Acute ADJ B-LF
respiratory ADJ I-LF
infection NOUN I-LF
( PUNCT B-O
ARI PROPN B-AC
) PUNCT B-O
and CCONJ B-O
diarrhoea NOUN B-O
are AUX B-O
the DET B-O
leading VERB B-O
causes NOUN B-O
of ADP B-O
childhood NOUN B-O
morbidity NOUN B-O
and CCONJ B-O
mortality NOUN B-O
in ADP B-O
Ethiopia PROPN B-O
. PUNCT B-O

Clinical ADJ B-O
outcomes NOUN B-O
and CCONJ B-O
the DET B-O
proportion NOUN B-O
of ADP B-O
justified ADJ B-O
use NOUN B-O
of ADP B-O
personal ADJ B-O
nursing NOUN B-O
care NOUN B-O
were AUX B-O
evaluated VERB B-O
using VERB B-O
a DET B-O
statistical ADJ B-O
technique NOUN B-O
known VERB B-O
as ADP B-O
Generalized PROPN B-LF
Pairwise PROPN I-LF
Comparisons PROPN I-LF
( PUNCT B-O
GPC PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
46 NUM B-O
] PUNCT B-O
. PUNCT B-O

Within ADP B-O
the DET B-O
control NOUN B-O
group NOUN B-O
CRMP-5 PROPN B-AC
was AUX B-O
verified VERB B-O
with ADP B-O
a DET B-O
label NOUN B-LF
- PUNCT I-LF
free ADJ I-LF
quantification NOUN I-LF
intensity NOUN I-LF
( PUNCT B-O
LFQI PROPN B-AC
) PUNCT B-O
of ADP B-O
1.93x109 NUM B-O
. PUNCT B-O

Notably ADV B-O
, PUNCT B-O
although SCONJ B-O
it PRON B-O
has AUX B-O
previously ADV B-O
been AUX B-O
hypothesized VERB B-O
that SCONJ B-O
the DET B-O
hormonal ADJ B-O
drivers NOUN B-O
of ADP B-O
PD PROPN B-AC
would AUX B-O
result VERB B-O
in ADP B-O
it PRON B-O
being AUX B-O
a DET B-O
stronger ADJ B-O
risk NOUN B-O
marker NOUN B-O
for ADP B-O
oestrogen NOUN B-LF
receptor NOUN I-LF
( PUNCT B-O
ER)–positive PROPN B-AC
than ADP B-O
ER PROPN B-AC
- PUNCT B-O
negative ADJ B-O
breast NOUN B-O
cancer NOUN B-O
, PUNCT B-O
a DET B-O
large ADJ B-O
differential NOUN B-O
in ADP B-O
the DET B-O
MD PROPN B-AC
- PUNCT B-O
breast NOUN B-O
cancer NOUN B-O
association NOUN B-O
by ADP B-O
tumour NOUN B-O
subtype NOUN B-O
does AUX B-O
not PART B-O
appear VERB B-O
to PART B-O
be AUX B-O
present ADJ B-O
[ PUNCT B-O
23 NUM B-O
] PUNCT B-O
. PUNCT B-O

Interleukins NOUN B-LF
( PUNCT B-O
ILs PROPN B-AC
) PUNCT B-O
are AUX B-O
a DET B-O
group NOUN B-O
of ADP B-O
cytokines NOUN B-O
that PRON B-O
are AUX B-O
involved VERB B-O
in ADP B-O
the DET B-O
communication NOUN B-O
between ADP B-O
immune ADJ B-O
and CCONJ B-O
inflammatory ADJ B-O
cells NOUN B-O
, PUNCT B-O
and CCONJ B-O
38 NUM B-O
ILs PROPN B-AC
have AUX B-O
been AUX B-O
identified VERB B-O
thus ADV B-O
far ADV B-O
. PUNCT B-O

There PRON B-O
are VERB B-O
different ADJ B-O
types NOUN B-O
of ADP B-O
medication NOUN B-O
reviews NOUN B-O
, PUNCT B-O
ranging VERB B-O
from ADP B-O
a DET B-O
prescription NOUN B-O
review NOUN B-O
( PUNCT B-O
which PRON B-O
is AUX B-O
basically ADV B-O
an DET B-O
evaluation NOUN B-O
of ADP B-O
the DET B-O
list NOUN B-O
of ADP B-O
prescribed VERB B-O
medicines NOUN B-O
) PUNCT B-O
to ADP B-O
a DET B-O
clinical ADJ B-LF
medication NOUN I-LF
review NOUN I-LF
( PUNCT B-O
CMR PROPN B-AC
; PUNCT B-O
with ADP B-O
the DET B-O
availability NOUN B-O
of ADP B-O
all DET B-O
clinical ADJ B-O
data NOUN B-O
and CCONJ B-O
an DET B-O
extensive ADJ B-O
patient NOUN B-O
interview NOUN B-O
) PUNCT B-O
[ PUNCT B-O
3 NUM B-O
] PUNCT B-O
. PUNCT B-O

Sural ADJ B-LF
sensory ADJ I-LF
nerve NOUN I-LF
amplitude NOUN I-LF
( PUNCT B-O
SSNamp PROPN B-AC
) PUNCT B-O
, PUNCT B-O
sural ADJ B-LF
sensory ADJ I-LF
nerve NOUN I-LF
conduction NOUN I-LF
velocity NOUN I-LF
( PUNCT B-O
SSNCV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
peroneal ADJ B-LF
motor NOUN I-LF
nerve NOUN I-LF
amplitude NOUN I-LF
( PUNCT B-O
PMNamp PROPN B-AC
) PUNCT B-O
and CCONJ B-O
peroneal ADJ B-LF
motor NOUN I-LF
nerve NOUN I-LF
conduction NOUN I-LF
velocity NOUN I-LF
( PUNCT B-O
PMNCV PROPN B-AC
) PUNCT B-O
were AUX B-O
assessed VERB B-O
using VERB B-O
a DET B-O
Dantec PROPN B-O
“ PUNCT B-O
Keypoint PROPN B-O
” PUNCT B-O
system NOUN B-O
( PUNCT B-O
Dantec PROPN B-O
Dynamics PROPN B-O
Ltd PROPN B-O
, PUNCT B-O
Bristol PROPN B-O
, PUNCT B-O
UK PROPN B-O
) PUNCT B-O
. PUNCT B-O

DF PROPN B-AC
, PUNCT B-O
dorsal ADJ B-LF
funiculus NOUN I-LF
; PUNCT B-O
dVL PROPN B-AC
, PUNCT B-O
dorsal ADJ B-LF
ventricular ADJ I-LF
layer NOUN I-LF
; PUNCT B-O
NKX6.1 NOUN B-O
, PUNCT B-O
NK6 NOUN B-O
homeobox NOUN B-O
1 NUM B-O
; PUNCT B-O
SOX2 PROPN B-O
, PUNCT B-O
SRY NOUN B-O
- PUNCT B-O
related VERB B-O
HMG NOUN B-O
- PUNCT B-O
box NOUN B-O
2 NUM B-O
; PUNCT B-O
VF PROPN B-AC
, PUNCT B-O
ventral ADJ B-LF
funiculus NOUN I-LF
; PUNCT B-O
VL PROPN B-AC
, PUNCT B-O
ventricular ADJ B-LF
layer NOUN I-LF
; PUNCT B-O
vVL PROPN B-AC
, PUNCT B-O
ventral ADJ B-LF
ventricular ADJ B-LF
layer NOUN I-LF
; PUNCT B-O
( PUNCT B-O
+ PUNCT B-O
) PUNCT B-O
, PUNCT B-O
expressing NOUN B-O
. PUNCT B-O

Powers PROPN B-O
et PROPN B-O
al NOUN B-O
. PUNCT B-O

estimated VERB B-O
that SCONJ B-O
the DET B-O
fraction NOUN B-LF
of ADP I-LF
HIV PROPN I-LF
incidence NOUN I-LF
attributable ADJ I-LF
to PART I-LF
transmission NOUN I-LF
from ADP I-LF
acutely ADV I-LF
infected VERB I-LF
individuals NOUN I-LF
( PUNCT B-O
AFacute PROPN B-AC
) PUNCT B-O
was AUX B-O
40 NUM B-O
% NOUN B-O
[ PUNCT B-O
19 NUM B-O
] PUNCT B-O
, PUNCT B-O
while SCONJ B-O
Williams PROPN B-O
et PROPN B-O
al NOUN B-O
. PUNCT B-O

argued VERB B-O
that SCONJ B-O
AFacute PROPN B-AC
was AUX B-O
more ADV B-O
likely ADJ B-O
to PART B-O
be AUX B-O
2%–4 NUM B-O
% NOUN B-O
[ PUNCT B-O
44 NUM B-O
] PUNCT B-O
. PUNCT B-O

Is AUX B-O
six NUM B-LF
- PUNCT I-LF
minute NOUN I-LF
- PUNCT I-LF
walk NOUN I-LF
distance NOUN I-LF
" PUNCT B-O
6MWD PROPN B-AC
” PUNCT B-O
? PUNCT B-O
Is AUX B-O
six NUM B-LF
- PUNCT I-LF
minute NOUN I-LF
- PUNCT I-LF
walk NOUN I-LF
test NOUN I-LF
" PUNCT B-O
6MWT PROPN B-AC
” PUNCT B-O
? PUNCT B-O
（ PUNCT B-O
Line NOUN B-O
55 NUM B-O
） PUNCT B-O
Response NOUN B-O
: PUNCT B-O
We PRON B-O
have AUX B-O
revised VERB B-O
the DET B-O
abbreviations NOUN B-O
in ADP B-O
the DET B-O
manuscript NOUN B-O
. PUNCT B-O

The DET B-O
primary ADJ B-O
trial NOUN B-O
outcome NOUN B-O
was AUX B-O
a DET B-O
composite ADJ B-O
endpoint NOUN B-O
of ADP B-O
women NOUN B-O
’s PART B-O
retention NOUN B-O
in ADP B-O
ART PROPN B-AC
care NOUN B-O
and CCONJ B-O
viral ADJ B-LF
suppression NOUN I-LF
( PUNCT B-O
VS PROPN B-AC
) PUNCT B-O
( PUNCT B-O
viral ADJ B-O
load NOUN B-O
< ADP B-O
50 NUM B-O
copies NOUN B-O
/ SYM B-O
ml NOUN B-O
) PUNCT B-O
at ADP B-O
12 NUM B-O
months NOUN B-O
postpartum ADV B-O
; PUNCT B-O
secondary ADJ B-O
outcomes NOUN B-O
included VERB B-O
duration NOUN B-O
of ADP B-O
any PRON B-O
and CCONJ B-O
exclusive ADJ B-O
breastfeeding NOUN B-O
, PUNCT B-O
mother NOUN B-O
- PUNCT B-O
to ADP B-O
- PUNCT B-O
child NOUN B-O
HIV PROPN B-O
transmission NOUN B-O
, PUNCT B-O
and CCONJ B-O
infant NOUN B-O
mortality NOUN B-O
. PUNCT B-O

The DET B-O
MSIS-29 PROPN B-AC
consists VERB B-O
of ADP B-O
29 NUM B-O
questions NOUN B-O
answered VERB B-O
on ADP B-O
a DET B-O
5 NUM B-O
- PUNCT B-O
point NOUN B-O
Likert PROPN B-O
scale NOUN B-O
, PUNCT B-O
giving VERB B-O
2 NUM B-O
scores NOUN B-O
: PUNCT B-O
the DET B-O
MSIS-29 PROPN B-LF
physical ADJ I-LF
MSIS-29 PROPN B-AC
( PUNCT B-O
MSIS-29 PROPN B-AC
) PUNCT B-O
score NOUN B-O
( PUNCT B-O
questions NOUN B-O
1–20 NUM B-O
; PUNCT B-O
therefore ADV B-O
score NOUN B-O
range NOUN B-O
20–100 NUM B-O
) PUNCT B-O
and CCONJ B-O
the DET B-O
MSIS-29 PROPN B-LF
psychological ADJ I-LF
-PHYSMSIS-29 PROPN B-AC
( PUNCT B-O
MSIS-29 PROPN B-AC
) PUNCT B-O
score NOUN B-O
( PUNCT B-O
questions NOUN B-O
21–29 NUM B-O
; PUNCT B-O
therefore ADV B-O
score NOUN B-O
range NOUN B-O
9–45 NUM B-O
) PUNCT B-O
[ PUNCT B-O
14,26 NUM B-O
] PUNCT B-O
. PUNCT B-O

Metabolic ADJ B-LF
syndrome NOUN I-LF
( PUNCT B-O
MetS PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
cluster NOUN B-O
of ADP B-O
risk NOUN B-O
factors NOUN B-O
that PRON B-O
encompasses VERB B-O
metabolic ADJ B-O
, PUNCT B-O
vascular ADJ B-O
, PUNCT B-O
and CCONJ B-O
inflammatory ADJ B-O
indicators NOUN B-O
. PUNCT B-O

Portal ADJ B-LF
Venous ADJ I-LF
Thrombosis NOUN I-LF
( PUNCT B-O
PVT PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
common ADJ B-O
complication NOUN B-O
of ADP B-O
Hepatocellular ADJ B-LF
Carcinoma PROPN I-LF
( PUNCT B-O
HCC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
assessed VERB B-O
as ADP B-O
adverse ADJ B-O
prognostic ADJ B-O
factor NOUN B-O
and CCONJ B-O
parameter NOUN B-O
of ADP B-O
tumor NOUN B-O
aggressiveness NOUN B-O
together ADV B-O
with ADP B-O
tumor NOUN B-O
size NOUN B-O
, PUNCT B-O
multifocality NOUN B-O
and CCONJ B-O
Alpha NOUN B-LF
- PUNCT I-LF
fetoprotein NOUN I-LF
( PUNCT B-O
AFP PROPN B-AC
) PUNCT B-O
levels NOUN B-O
[ PUNCT B-O
1,2 NUM B-O
] PUNCT B-O
. PUNCT B-O

These DET B-O
estimates NOUN B-O
do AUX B-O
not PART B-O
account VERB B-O
for ADP B-O
immunity NOUN B-O
resulting VERB B-O
from ADP B-O
transmission NOUN B-O
of ADP B-O
OPV PROPN B-AC
among ADP B-O
contacts NOUN B-O
of ADP B-O
vaccinated VERB B-O
children NOUN B-O
, PUNCT B-O
maternally ADV B-O
derived VERB B-O
antibodies NOUN B-O
, PUNCT B-O
or CCONJ B-O
naturally ADV B-O
acquired VERB B-O
immunity NOUN B-O
following VERB B-O
exposure NOUN B-O
to ADP B-O
cVDPV2 PROPN B-AC
. PUNCT B-O

In ADP B-O
Nigeria PROPN B-O
, PUNCT B-O
receipt NOUN B-O
of ADP B-O
tOPV PROPN B-AC
through ADP B-O
RI PROPN B-AC
was AUX B-O
inferred VERB B-O
from ADP B-O
district NOUN B-O
- PUNCT B-O
level NOUN B-O
coverage NOUN B-O
with ADP B-O
three NUM B-O
doses NOUN B-O
of ADP B-O
diphtheria NOUN B-O
- PUNCT B-O
tetanus NOUN B-O
- PUNCT B-O
pertussis NOUN B-O
( PUNCT B-O
DTP3 PROPN B-O
) PUNCT B-O
vaccine NOUN B-O
at ADP B-O
the DET B-O
age NOUN B-O
of ADP B-O
12 NUM B-O
mo NOUN B-O
or CCONJ B-O
later ADV B-O
estimated VERB B-O
from ADP B-O
Demographic PROPN B-LF
and CCONJ I-LF
Health PROPN I-LF
Surveys PROPN I-LF
( PUNCT B-O
DHS PROPN B-AC
) PUNCT B-O
data NOUN B-O
( PUNCT B-O
estimates NOUN B-O
are AUX B-O
derived VERB B-O
in ADP B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Coxsackievirus PROPN B-LF
B PROPN I-LF
( PUNCT B-O
CVB PROPN B-AC
) PUNCT B-O
belongs VERB B-O
to ADP B-O
the DET B-O
Enterovirus NOUN B-O
B PROPN B-O
species NOUN B-O
of ADP B-O
the DET B-O
Picornaviridae PROPN B-O
family NOUN B-O
and CCONJ B-O
has AUX B-O
been AUX B-O
associated VERB B-O
with ADP B-O
a DET B-O
wide ADJ B-O
range NOUN B-O
of ADP B-O
diseases NOUN B-O
from ADP B-O
mild ADJ B-O
respiratory ADJ B-O
infections NOUN B-O
to ADP B-O
more ADV B-O
severe ADJ B-O
infections NOUN B-O
of ADP B-O
the DET B-O
central ADJ B-O
nervous ADJ B-O
system NOUN B-O
, PUNCT B-O
heart NOUN B-O
and CCONJ B-O
pancreas NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
systematically ADV B-O
investigate VERB B-O
the DET B-O
influence NOUN B-O
of ADP B-O
potentially ADV B-O
functional ADJ B-O
coding VERB B-O
polymorphisms NOUN B-O
in ADP B-O
the DET B-O
NLR PROPN B-O
genes NOUN B-O
on ADP B-O
sporadic ADJ B-O
CRC PROPN B-AC
risk NOUN B-O
and CCONJ B-O
survival NOUN B-O
, PUNCT B-O
we PRON B-O
conducted VERB B-O
a DET B-O
case NOUN B-O
- ADJ B-O
control NOUN B-O
study NOUN B-O
with ADP B-O
replications NOUN B-O
in ADP B-O
2 NUM B-O
large ADJ B-O
genome NOUN B-O
- ADJ B-O
wide ADJ B-O
association NOUN B-O
studies NOUN B-O
( PUNCT B-O
GWASs PROPN B-O
) PUNCT B-O
, PUNCT B-O
covering VERB B-O
the DET B-O
majority NOUN B-O
of ADP B-O
known VERB B-O
non ADJ B-LF
- ADJ I-LF
synonymous ADJ I-LF
single ADJ I-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT B-O
nsSNPs PROPN B-AC
) PUNCT B-O
in ADP B-O
21 NUM B-O
genes NOUN B-O
across ADP B-O
different ADJ B-O
NLR PROPN B-O
signalling NOUN B-O
pathways NOUN B-O
. PUNCT B-O

Progress NOUN B-LF
variables NOUN I-LF
( PUNCT B-O
PVs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
akin ADJ B-O
to ADP B-O
reaction NOUN B-O
coordinates NOUN B-O
, PUNCT B-O
for ADP B-O
all DET B-O
free ADJ B-O
- PUNCT B-O
energy NOUN B-O
molecular ADJ B-O
dynamics NOUN B-O
calculations NOUN B-O
were AUX B-O
chosen VERB B-O
as ADP B-O
the DET B-O
location NOUN B-O
on ADP B-O
the DET B-O
z NOUN B-O
axis NOUN B-O
of ADP B-O
the DET B-O
center NOUN B-O
of ADP B-O
mass NOUN B-O
of ADP B-O
the DET B-O
small ADJ B-O
- PUNCT B-O
molecule(s NOUN B-O
) PUNCT B-O
of ADP B-O
interest NOUN B-O
. PUNCT B-O

Non ADJ B-LF
- ADJ I-LF
alcoholic ADJ I-LF
fatty ADJ I-LF
liver NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
NAFLD PROPN B-AC
) PUNCT B-O
is AUX B-O
defined VERB B-O
as ADP B-O
the DET B-O
accumulation NOUN B-O
of ADP B-O
excess ADJ B-O
, PUNCT B-O
microscopically ADV B-O
visible ADJ B-O
lipid NOUN B-O
in ADP B-O
hepatocytes NOUN B-O
in ADP B-O
the DET B-O
absence NOUN B-O
of ADP B-O
excessive ADJ B-O
alcohol NOUN B-O
consumption NOUN B-O
and CCONJ B-O
is AUX B-O
now ADV B-O
the DET B-O
most ADV B-O
common ADJ B-O
chronic ADJ B-O
liver NOUN B-O
disease NOUN B-O
in ADP B-O
developed VERB B-O
countries NOUN B-O
[ PUNCT B-O
1 NUM B-O
, PUNCT B-O
2 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
current ADJ B-O
prequalified ADJ B-O
oral ADJ B-LF
cholera NOUN I-LF
vaccines NOUN I-LF
( PUNCT B-O
OCVs PROPN B-AC
) PUNCT B-O
provide VERB B-O
over ADP B-O
80 NUM B-O
% NOUN B-O
( PUNCT B-O
direct ADJ B-O
) PUNCT B-O
protection NOUN B-O
in ADP B-O
the DET B-O
first ADJ B-O
6 NUM B-O
mo NOUN B-O
after ADP B-O
vaccination NOUN B-O
[ PUNCT B-O
2–4 NUM B-O
] PUNCT B-O
, PUNCT B-O
with ADP B-O
protection NOUN B-O
of ADP B-O
up ADP B-O
to PART B-O
65 NUM B-O
% NOUN B-O
for ADP B-O
5 NUM B-O
y NOUN B-O
estimated VERB B-O
in ADP B-O
an DET B-O
endemic ADJ B-O
setting NOUN B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
volatile ADJ B-LF
fatty ADJ I-LF
acids NOUN I-LF
( PUNCT B-O
VFAs PROPN B-AC
) PUNCT B-O
in ADP B-O
HARs PROPN B-AC
and CCONJ B-O
BRs PROPN B-AC
were AUX B-O
measured VERB B-O
acetic ADJ B-O
, PUNCT B-O
propionate NOUN B-O
, PUNCT B-O
iso ADJ B-O
- PUNCT B-O
butyric ADJ B-O
, PUNCT B-O
butyric ADJ B-O
, PUNCT B-O
valeric ADJ B-O
and CCONJ B-O
iso ADJ B-O
- PUNCT B-O
valeric ADJ B-O
acid NOUN B-O
by ADP B-O
GC PROPN B-O
( PUNCT B-O
GC-2001 PROPN B-O
, PUNCT B-O
Shimadzu PROPN B-O
, PUNCT B-O
Japan PROPN B-O
) PUNCT B-O
equipped VERB B-O
with ADP B-O
hydrogen NOUN B-O
flame NOUN B-O
ionization NOUN B-O
detector NOUN B-O
( PUNCT B-O
FID PROPN B-O
) PUNCT B-O
using VERB B-O
Nitrogen PROPN B-O
as ADP B-O
a DET B-O
carrier NOUN B-O
gas NOUN B-O
in ADP B-O
a DET B-O
quartz NOUN B-O
capillary NOUN B-O
column NOUN B-O
( PUNCT B-O
30 NUM B-O
m×0.32 NUM B-O
mm×D×0.25 NUM B-O
μm NOUN B-O
; PUNCT B-O
Stabilwax PROPN B-O
- PUNCT B-O
DA PROPN B-O
, PUNCT B-O
RESTEK PROPN B-O
, PUNCT B-O
USA PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
GC PROPN B-O
was AUX B-O
operated VERB B-O
when SCONJ B-O
the DET B-O
injection NOUN B-O
port NOUN B-O
and CCONJ B-O
detector NOUN B-O
temperatures NOUN B-O
were AUX B-O
220 NUM B-O
° NUM B-O
C NOUN B-O
and CCONJ B-O
230 NUM B-O
° NUM B-O
C NOUN B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O

Concurrently ADV B-O
, PUNCT B-O
Ca2 NOUN B-O
+ NOUN B-O
binding VERB B-O
to ADP B-O
another DET B-O
synaptic ADJ B-O
vesicle NOUN B-O
associated VERB B-O
protein NOUN B-O
, PUNCT B-O
Synaptotagmin PROPN B-LF
1 NUM I-LF
( PUNCT B-O
Syt1 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
triggers VERB B-O
the DET B-O
migration NOUN B-O
of ADP B-O
synaptic ADJ B-O
vesicles NOUN B-O
towards ADP B-O
the DET B-O
plasma NOUN B-O
membrane NOUN B-O
, PUNCT B-O
with ADP B-O
Syt1 PROPN B-AC
mediating VERB B-O
the DET B-O
docking NOUN B-O
, PUNCT B-O
fusion NOUN B-O
and CCONJ B-O
exocytosis NOUN B-O
of ADP B-O
the DET B-O
readily ADV B-O
releasable ADJ B-O
synaptic ADJ B-O
vesicles NOUN B-O
at ADP B-O
the DET B-O
synaptic ADJ B-O
cleft NOUN B-O
[ PUNCT B-O
30–32 NUM B-O
] PUNCT B-O
. PUNCT B-O

Light NOUN B-O
induced VERB B-O
c NOUN B-O
- PUNCT B-O
Fos NOUN B-O
immunoreactivity NOUN B-O
in ADP B-O
the DET B-O
suprachiasmatic ADJ B-O
nuclei NOUN B-O
( PUNCT B-O
SCN PROPN B-AC
) PUNCT B-O
and CCONJ B-O
in ADP B-O
sleep NOUN B-O
- PUNCT B-O
active ADJ B-O
ventrolateral ADJ B-LF
preoptic ADJ I-LF
( PUNCT B-O
VLPO PROPN B-AC
) PUNCT B-O
neurons NOUN B-O
was AUX B-O
importantly ADV B-O
reduced VERB B-O
in ADP B-O
Opn4−/− PROPN B-O
mice NOUN B-O
, PUNCT B-O
implicating VERB B-O
both DET B-O
sleep NOUN B-O
- PUNCT B-O
regulatory ADJ B-O
structures NOUN B-O
in ADP B-O
the DET B-O
melanopsin NOUN B-O
- PUNCT B-O
mediated VERB B-O
effects NOUN B-O
of ADP B-O
light NOUN B-O
. PUNCT B-O

SDS PROPN B-O
- ADJ B-O
PAGE PROPN B-O
under ADP B-O
reducing VERB B-O
conditions NOUN B-O
of ADP B-O
antithrombin ADJ B-O
in ADP B-O
complex NOUN B-O
with ADP B-O
FXa PROPN B-O
upon SCONJ B-O
activation NOUN B-O
with ADP B-O
low ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
heparin NOUN I-LF
( PUNCT B-O
LMWH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
active ADJ B-O
heparanase NOUN B-O
( PUNCT B-O
HPSE PROPN B-O
) PUNCT B-O
, PUNCT B-O
10 NUM B-O
- ADJ B-O
fold ADJ B-O
concentrated ADJ B-O
medium NOUN B-O
of ADP B-O
cells NOUN B-O
transfected VERB B-O
with ADP B-O
proheparanase NOUN B-O
( PUNCT B-O
mProHPSE PROPN B-O
) PUNCT B-O
; PUNCT B-O
10 NUM B-O
- ADJ B-O
fold ADJ B-O
concentrated ADJ B-O
medium NOUN B-O
of ADP B-O
cells NOUN B-O
transfected VERB B-O
with ADP B-O
an DET B-O
empty ADJ B-O
plasmid NOUN B-O
but CCONJ B-O
supplemented VERB B-O
with ADP B-O
active ADJ B-O
heparanase NOUN B-O
( PUNCT B-O
mHPSE PROPN B-O
) PUNCT B-O
. PUNCT B-O

Detection NOUN B-O
was AUX B-O
done VERB B-O
by ADP B-O
western ADJ B-O
blot NOUN B-O
using VERB B-O
an DET B-O
anti ADJ B-O
- ADJ B-O
antithrombin ADJ B-O
antibody NOUN B-O
. PUNCT B-O

Treating VERB B-O
hyperglycemia NOUN B-O
in ADP B-O
previously ADV B-O
non ADJ B-O
- PUNCT B-O
diabetic ADJ B-O
individuals NOUN B-O
with ADP B-O
exogenous ADJ B-O
insulin NOUN B-O
immediately ADV B-O
after ADP B-O
kidney NOUN B-O
transplantation NOUN B-O
reduced VERB B-O
the DET B-O
odds NOUN B-O
of ADP B-O
developing VERB B-O
Posttransplantation PROPN B-LF
Diabetes PROPN I-LF
Mellitus PROPN I-LF
( PUNCT B-O
PTDM PROPN B-AC
) PUNCT B-O
in ADP B-O
our PRON B-O
previous ADJ B-O
proof NOUN B-O
- PUNCT B-O
of ADP B-O
- PUNCT B-O
concept NOUN B-O
clinical ADJ B-O
trial NOUN B-O
. PUNCT B-O

Our PRON B-O
dataset NOUN B-O
comprised VERB B-O
40 NUM B-O
acylcarnitines NOUN B-O
, PUNCT B-O
34 NUM B-O
lipids NOUN B-O
( PUNCT B-O
14 NUM B-O
lysophospholipids NOUN B-O
, PUNCT B-O
10 NUM B-O
sphingolipids NOUN B-O
, PUNCT B-O
and CCONJ B-O
10 NUM B-O
phosphatidylcholines NOUN B-O
) PUNCT B-O
, PUNCT B-O
24 NUM B-O
amino ADJ B-O
acids NOUN B-O
, PUNCT B-O
16 NUM B-O
organic ADJ B-O
acids NOUN B-O
, PUNCT B-O
12 NUM B-O
biogenic ADJ B-O
amines NOUN B-O
, PUNCT B-O
and CCONJ B-O
4 NUM B-O
metabolites NOUN B-O
classified VERB B-O
as ADP B-O
‘ PUNCT B-O
other ADJ B-O
’ PUNCT B-O
( PUNCT B-O
creatine NOUN B-O
, PUNCT B-O
choline NOUN B-O
, PUNCT B-O
trimethylamine NOUN B-LF
N NOUN I-LF
- PUNCT I-LF
oxide NOUN I-LF
[ PUNCT B-O
TMAO PROPN B-AC
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
glucose NOUN B-O
) PUNCT B-O
. PUNCT B-O

Brazil PROPN B-O
’s PART B-O
considerable ADJ B-O
investments NOUN B-O
in ADP B-O
social ADJ B-O
protection NOUN B-O
policies NOUN B-O
over ADP B-O
the DET B-O
last ADJ B-O
two NUM B-O
decades NOUN B-O
include VERB B-O
the DET B-O
rollout NOUN B-O
of ADP B-O
conditional ADJ B-O
cash NOUN B-O
transfers NOUN B-O
under ADP B-O
the DET B-O
Bolsa PROPN B-O
Família PROPN B-O
programme NOUN B-O
and CCONJ B-O
a DET B-O
commitment NOUN B-O
to ADP B-O
UHC PROPN B-AC
with ADP B-O
the DET B-O
expansion NOUN B-O
of ADP B-O
PHC PROPN B-AC
through ADP B-O
the DET B-O
Estratégia PROPN B-LF
de ADP I-LF
Saúde PROPN I-LF
da PROPN I-LF
Família PROPN I-LF
( PUNCT B-O
ESF PROPN B-AC
) PUNCT B-O
( PUNCT B-O
family NOUN B-O
health NOUN B-O
strategy NOUN B-O
) PUNCT B-O
[ PUNCT B-O
14,15 NUM B-O
] PUNCT B-O
. PUNCT B-O

For ADP B-O
comparison NOUN B-O
to ADP B-O
the DET B-O
Global PROPN B-LF
Lipids PROPN I-LF
Genetics PROPN I-LF
Consortium PROPN I-LF
( PUNCT B-O
GLGC PROPN B-AC
) PUNCT B-O
lipid NOUN B-O
panel NOUN B-O
and CCONJ B-O
extension NOUN B-O
to ADP B-O
other ADJ B-O
lipoproteins NOUN B-O
, PUNCT B-O
we PRON B-O
also ADV B-O
included VERB B-O
the DET B-O
2019 NUM B-O
release NOUN B-O
of ADP B-O
the DET B-O
Neale PROPN B-O
Lab PROPN B-O
UKB PROPN B-AC
GWAS PROPN B-AC
( PUNCT B-O
automated ADJ B-O
diastolic ADJ B-O
and CCONJ B-O
systolic ADJ B-O
blood NOUN B-LF
pressure NOUN I-LF
( PUNCT B-O
BP PROPN B-AC
) PUNCT B-O
measurement NOUN B-O
) PUNCT B-O
and CCONJ B-O
their PRON B-O
biochemistry NOUN B-O
panel NOUN B-O
( PUNCT B-O
HDL PROPN B-AC
, PUNCT B-O
-CLDL PROPN B-AC
direct ADJ B-O
, PUNCT B-O
-CTRG PROPN B-AC
, PUNCT B-O
apolipoprotein NOUN B-LF
A NOUN I-LF
( PUNCT B-O
ApoA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
ApoB PROPN B-AC
, PUNCT B-O
and CCONJ B-O
lipoprotein NOUN B-O
A NOUN B-O
) PUNCT B-O
[ PUNCT B-O
36 NUM B-O
] PUNCT B-O
. PUNCT B-O

CH PROPN B-AC
, PUNCT B-O
chronic ADJ B-LF
hepatitis NOUN I-LF
; PUNCT B-O
LC PROPN B-AC
, PUNCT B-O
liver NOUN B-O
cirrhotic ADJ B-O
; PUNCT B-O
HCC PROPN B-AC
, PUNCT B-O
hepatocellular ADJ B-LF
carcinoma NOUN I-LF
; PUNCT B-O
SNP PROPN B-AC
, PUNCT B-O
single ADJ B-LF
nucleotide NOUN I-LF
polymorphism NOUN I-LF
; PUNCT B-O
HWE PROPN B-AC
, PUNCT B-O
Hardy PROPN B-LF
- PUNCT I-LF
Weinberg PROPN I-LF
Equilibrium PROPN I-LF
; PUNCT B-O
Del PROPN B-O
, PUNCT B-O
deletion NOUN B-O
; PUNCT B-O
ID NOUN B-O
, PUNCT B-O
insertion NOUN B-O
+ SYM B-O
deletion NOUN B-O
; PUNCT B-O
Ht PROPN B-AC
, PUNCT B-O
haplotype NOUN B-LF
. PUNCT B-O

Foam NOUN B-O
cell NOUN B-O
formation NOUN B-O
is AUX B-O
regulated VERB B-O
by ADP B-O
several ADJ B-O
factors NOUN B-O
: NOUN B-O
1 NUM B-O
) PUNCT B-O
scavenger NOUN B-O
receptors NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
CD36 PROPN B-AC
and CCONJ B-O
lectin NOUN B-O
- NOUN B-O
like ADJ B-O
ox- NOUN B-O
low ADJ B-LF
- NOUN I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
( PUNCT B-O
LDL PROPN B-AC
) PUNCT B-O
receptor-1 NOUN B-O
( PUNCT B-O
Lox-1 PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
, PUNCT B-O
2 X B-O
) PUNCT B-O
acyl NOUN B-O
- NOUN B-O
coenzyme NOUN B-O
A NOUN B-O
: NOUN B-O
cholesterol NOUN B-O
acyltransferase NOUN B-O
1 NUM B-O
( PUNCT B-O
ACAT1 PROPN B-O
) PUNCT B-O
, PUNCT B-O
a DET B-O
rate NOUN B-O
- NOUN B-O
limiting VERB B-O
enzyme NOUN B-O
for ADP B-O
the DET B-O
esterification NOUN B-O
of ADP B-O
cholesterol NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
3 X B-O
) PUNCT B-O
free ADJ B-O
- NOUN B-O
cholesterol NOUN B-O
efflux NOUN B-O
mediated VERB B-O
by ADP B-O
ATP PROPN B-O
- NOUN B-O
binding VERB B-O
cassette NOUN B-O
transporter NOUN B-O
A1 NOUN B-O
( PUNCT B-O
ABCA1 PROPN B-O
) PUNCT B-O
and CCONJ B-O
ATP PROPN B-O
- NOUN B-O
binding VERB B-O
cassette NOUN B-O
sub NOUN B-O
- NOUN B-O
family NOUN B-O
G NOUN B-O
member NOUN B-O
1 NUM B-O
( PUNCT B-O
ABCG1 PROPN B-O
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

Events NOUN B-O
corresponding VERB B-O
to PART B-O
γδ PUNCT B-O
T NOUN B-O
( PUNCT B-O
green ADJ B-O
) PUNCT B-O
, PUNCT B-O
invariant ADJ B-O
natural ADJ B-O
killer NOUN B-O
T NOUN B-O
( PUNCT B-O
iNKT PROPN B-AC
) PUNCT B-O
( PUNCT B-O
red ADJ B-O
) PUNCT B-O
, PUNCT B-O
MAIT PROPN B-AC
( PUNCT B-O
blue ADJ B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
conventional ADJ B-O
T NOUN B-O
( PUNCT B-O
Tconv PROPN B-AC
) PUNCT B-O
( PUNCT B-O
cyan NOUN B-O
) PUNCT B-O
cells NOUN B-O
were AUX B-O
superimposed VERB B-O
to PART B-O
generate VERB B-O
a DET B-O
dot NOUN B-O
plot NOUN B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
frequency NOUN B-O
of ADP B-O
IFN PROPN B-AC
- NOUN B-O
γ+ NOUN B-O
cells NOUN B-O
and CCONJ B-O
the DET B-O
mean ADJ B-LF
fluorescence NOUN I-LF
intensity NOUN I-LF
( PUNCT B-O
MFI PROPN B-AC
) PUNCT B-O
of ADP B-O
IFN PROPN B-AC
- NOUN B-O
γ PUNCT B-O
staining NOUN B-O
were AUX B-O
determined VERB B-O
in ADP B-O
7 NUM B-O
donors NOUN B-O
, PUNCT B-O
each PRON B-O
of ADP B-O
whom PRON B-O
is AUX B-O
represented VERB B-O
by ADP B-O
a DET B-O
circle NOUN B-O
( PUNCT B-O
C NOUN B-O
) PUNCT B-O
. PUNCT B-O

Five NUM B-O
subpopulations NOUN B-O
were AUX B-O
defined VERB B-O
among ADP B-O
SEB PROPN B-AC
- NOUN B-O
stimulated VERB B-O
CD3 NOUN B-O
+ NOUN B-O
cells NOUN B-O
based VERB B-O
on ADP B-O
their PRON B-O
co NOUN B-O
- NOUN B-O
expression NOUN B-O
of ADP B-O
CD161 NOUN B-O
and CCONJ B-O
Vα7.2 NOUN B-O
, PUNCT B-O
or CCONJ B-O
lack NOUN B-O
thereof ADV B-O
. PUNCT B-O

Receiver NOUN B-O
- PUNCT B-O
operating VERB B-O
characteristic ADJ B-O
( PUNCT B-O
ROC PROPN B-AC
) PUNCT B-O
curves NOUN B-O
were AUX B-O
constructed VERB B-O
to PART B-O
calculate VERB B-O
the DET B-O
best ADJ B-O
cutoff NOUN B-O
values NOUN B-O
, PUNCT B-O
including VERB B-O
the DET B-O
area NOUN B-O
under ADP B-O
the DET B-O
curve NOUN B-O
( PUNCT B-O
AUC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT B-O
PPV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT B-O
NPV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
accuracy NOUN B-O
for ADP B-O
discriminating VERB B-O
H. NOUN B-O
pylori NOUN B-O
positivity NOUN B-O
, PUNCT B-O
chronic ADJ B-O
gastritis NOUN B-O
, PUNCT B-O
and CCONJ B-O
atrophic ADJ B-O
gastritis NOUN B-O
. PUNCT B-O

To ADP B-O
that DET B-O
end NOUN B-O
, PUNCT B-O
the DET B-LF
Cancer PROPN I-LF
Genome PROPN I-LF
Atlas PROPN I-LF
( PUNCT B-O
TCGA PROPN B-AC
) PUNCT B-O
was AUX B-O
used VERB B-O
to PART B-O
identify VERB B-O
samples NOUN B-O
from ADP B-O
LUSC PROPN B-AC
( PUNCT B-O
lung ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
) PUNCT B-O
and CCONJ B-O
LUAC PROPN B-AC
( PUNCT B-O
lung ADJ B-LF
adenocarcinoma NOUN I-LF
) PUNCT B-O
patients NOUN B-O
for ADP B-O
which PRON B-O
clinical ADJ B-O
follow VERB B-O
- PUNCT B-O
up ADP B-O
data NOUN B-O
was AUX B-O
available ADJ B-O
. PUNCT B-O

STROBE PROPN B-AC
, PUNCT B-O
Strengthening VERB B-LF
the DET I-LF
Reporting NOUN I-LF
of ADP I-LF
Observational ADJ I-LF
Studies NOUN I-LF
in ADP I-LF
Epidemiology NOUN I-LF
. PUNCT B-O

All DET B-O
these DET B-O
13 NUM B-O
genes NOUN B-O
are AUX B-O
co ADJ B-O
- ADJ B-O
DE PROPN B-AC
in ADP B-O
acute ADJ B-LF
megakaryoblastic ADJ I-LF
leukemia NOUN I-LF
( PUNCT B-O
AMKL PROPN B-AC
) PUNCT B-O
and CCONJ B-O
acute ADJ B-LF
myeloid ADJ I-LF
leukemia NOUN I-LF
( PUNCT B-O
AML PROPN B-AC
) PUNCT B-O
mononuclear ADJ B-O
cells NOUN B-O
. PUNCT B-O

Gi PROPN B-AC
, PUNCT B-O
nucleus NOUN B-LF
gigantocellularis NOUN I-LF
; PUNCT B-O
DR PROPN B-AC
, PUNCT B-O
dorsal ADJ B-LF
raphé NOUN I-LF
; PUNCT B-O
LC PROPN B-AC
, PUNCT B-O
locus NOUN B-LF
coeruleus NOUN I-LF
; PUNCT B-O
LDT PROPN B-AC
, PUNCT B-O
laterodorsal ADJ B-LF
tegmental ADJ I-LF
nucleus NOUN I-LF
; PUNCT B-O
PC PROPN B-AC
, PUNCT B-O
nucleus NOUN B-LF
pontis NOUN I-LF
caudalis NOUN I-LF
; PUNCT B-O
PO PROPN B-AC
, PUNCT B-O
nucleus NOUN B-LF
pontis NOUN I-LF
oralis ADJ I-LF
; PUNCT B-O
SubLC PROPN B-AC
, PUNCT B-O
subcoeruleus NOUN B-LF
PM2.5 PROPN B-AC
, PUNCT B-O
particulate NOUN B-LF
matter NOUN I-LF
with ADP I-LF
an DET I-LF
aerodynamic ADJ I-LF
diameter NOUN I-LF
less ADJ I-LF
than ADP I-LF
or CCONJ I-LF
equal ADJ I-LF
to ADP I-LF
2.5 NUM I-LF
μm NOUN I-LF
or CCONJ I-LF
fine ADJ I-LF
particulate NOUN I-LF
matter NOUN I-LF
; PUNCT B-O
YLL PROPN B-AC
, PUNCT B-O
years NOUN B-LF
of ADP I-LF
life NOUN I-LF
lost VERB I-LF
. PUNCT B-O

Inflammation NOUN B-O
is AUX B-O
an DET B-O
important ADJ B-O
factor NOUN B-O
in ADP B-O
the DET B-O
pathogenesis NOUN B-O
of ADP B-O
calcific ADJ B-O
aortic ADJ B-LF
stenosis NOUN I-LF
( PUNCT B-O
AS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

We PRON B-O
aimed VERB B-O
to ADP B-O
evaluate VERB B-O
the DET B-O
association NOUN B-O
between ADP B-O
an DET B-O
inflammatory ADJ B-O
marker NOUN B-O
, PUNCT B-O
neutrophil NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
lymphocyte NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
NLR PROPN B-AC
) PUNCT B-O
and CCONJ B-O
major ADJ B-LF
adverse ADJ I-LF
cardiovascular ADJ I-LF
events NOUN I-LF
( PUNCT B-O
MACE PROPN B-AC
) PUNCT B-O
in ADP B-O
patients NOUN B-O
with ADP B-O
severe ADJ B-O
calcific ADJ B-O
AS PROPN B-AC
. PUNCT B-O

Nuclei NOUN B-O
were AUX B-O
stained VERB B-O
by ADP B-O
4',6 NUM B-LF
- PUNCT I-LF
diamidino-2 NOUN I-LF
- PUNCT I-LF
phenylindole NOUN I-LF
( PUNCT B-O
DAPI PROPN B-AC
) PUNCT B-O
( PUNCT B-O
Sigma PROPN B-O
- PUNCT B-O
Aldrich PROPN B-O
, PUNCT B-O
Lyon PROPN B-O
, PUNCT B-O
France PROPN B-O
) PUNCT B-O
, PUNCT B-O
used VERB B-O
at ADP B-O
a DET B-O
1:2000 NUM B-O
dilution NOUN B-O
in ADP B-O
Mowiol PROPN B-O
mounting NOUN B-O
medium NOUN B-O
( PUNCT B-O
2.4 NUM B-O
g NOUN B-O
Mowiol PROPN B-O
4–88 NUM B-O
from ADP B-O
Sigma PROPN B-O
- PUNCT B-O
Aldrich PROPN B-O
, PUNCT B-O
6 NUM B-O
g NOUN B-O
glycerol NOUN B-O
, PUNCT B-O
6 NUM B-O
mL NOUN B-O
distilled VERB B-O
water NOUN B-O
, PUNCT B-O
12 NUM B-O
mL NOUN B-O
0.2 NUM B-O
M NOUN B-O
Tris NOUN B-O
- PUNCT B-O
Cl NOUN B-O
buffer NOUN B-O
· PUNCT B-O
pH NOUN B-O
8.5 NUM B-O
) PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
use VERB B-O
cryo NOUN B-LF
- PUNCT I-LF
electron NOUN I-LF
microscopy NOUN I-LF
( PUNCT B-O
cryoEM PROPN B-AC
) PUNCT B-O
to ADP B-O
decipher VERB B-O
the DET B-O
mechanism NOUN B-O
of ADP B-O
action NOUN B-O
of ADP B-O
a DET B-O
potent ADJ B-O
HA PROPN B-AC
head NOUN B-O
- PUNCT B-O
directed VERB B-O
monoclonal ADJ B-LF
antibody NOUN I-LF
( PUNCT B-O
mAb PROPN B-AC
) PUNCT B-O
bound VERB B-O
to ADP B-O
an DET B-O
influenza NOUN B-O
H7 PROPN B-O
HA PROPN B-AC
. PUNCT B-O

The DET B-O
epitope NOUN B-O
of ADP B-O
the DET B-O
antibody NOUN B-O
is AUX B-O
not PART B-O
solvent NOUN B-O
accessible ADJ B-O
in ADP B-O
the DET B-O
compact ADJ B-O
, PUNCT B-O
prefusion NOUN B-O
conformation NOUN B-O
that PRON B-O
typifies VERB B-O
all DET B-O
HA PROPN B-AC
structures NOUN B-O
to ADP B-O
date NOUN B-O
. PUNCT B-O

Matrix NOUN B-LF
effects NOUN I-LF
( PUNCT B-O
ME PROPN B-AC
) PUNCT B-O
, PUNCT B-O
extraction NOUN B-O
recoveries NOUN B-O
( PUNCT B-O
ER PROPN B-AC
) PUNCT B-O
and CCONJ B-O
process NOUN B-O
efficiencies NOUN B-O
( PUNCT B-O
PE PROPN B-AC
) PUNCT B-O
for ADP B-O
PBTZ169 PROPN B-O
, PUNCT B-O
five NUM B-O
active ADJ B-O
metabolites NOUN B-O
and CCONJ B-O
internal ADJ B-O
standards NOUN B-O
were AUX B-O
quantitatively ADV B-O
assessed VERB B-O
according VERB B-O
to ADP B-O
Matuszeswski PROPN B-O
’s PART B-O
procedures NOUN B-O
as ADP B-O
well ADV B-O
as ADP B-O
to ADP B-O
the DET B-O
recommendations NOUN B-O
of ADP B-O
the DET B-O
EMEA PROPN B-AC
/ SYM B-O
FDA PROPN B-AC
[ X B-O
27 NUM B-O
, PUNCT B-O
28 NUM B-O
] PUNCT B-O
. PUNCT B-O

Among ADP B-O
these DET B-O
measures NOUN B-O
are AUX B-O
years NOUN B-O
of ADP B-O
life NOUN B-O
lost VERB B-O
( PUNCT B-O
YLLs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
quantifies VERB B-O
the DET B-O
number NOUN B-O
of ADP B-O
years NOUN B-O
of ADP B-O
life NOUN B-O
lost VERB B-O
because SCONJ B-O
the DET B-O
person NOUN B-O
dies VERB B-O
prematurely ADV B-O
due ADP B-O
to ADP B-O
a DET B-O
disease NOUN B-O
or CCONJ B-O
injury NOUN B-O
; PUNCT B-O
years NOUN B-O
lived VERB B-O
with ADP B-O
disability NOUN B-O
( PUNCT B-O
YLDs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
quantifies VERB B-O
the DET B-O
healthy ADJ B-O
time NOUN B-O
lost VERB B-O
by ADP B-O
a DET B-O
person NOUN B-O
living VERB B-O
with ADP B-O
a DET B-O
disability NOUN B-O
caused VERB B-O
by ADP B-O
a DET B-O
disease NOUN B-O
or CCONJ B-O
injury NOUN B-O
; PUNCT B-O
and CCONJ B-O
disability NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
years NOUN I-LF
( PUNCT B-O
DALYs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
summary NOUN B-O
measure NOUN B-O
that PRON B-O
is AUX B-O
the DET B-O
sum NOUN B-O
of ADP B-O
YLLs PROPN B-AC
and CCONJ B-O
YLDs PROPN B-AC
[ PUNCT B-O
17 NUM B-O
] PUNCT B-O
. PUNCT B-O

Irrespective ADV B-O
of ADP B-O
familial ADJ B-O
relationship NOUN B-O
, PUNCT B-O
adults NOUN B-O
who PRON B-O
resided VERB B-O
with ADP B-O
another DET B-O
adult NOUN B-O
with ADP B-O
any DET B-O
chronic ADJ B-O
condition NOUN B-O
had VERB B-O
29 NUM B-O
% NOUN B-O
higher ADJ B-O
adjusted ADJ B-O
relative ADJ B-O
odds NOUN B-O
of ADP B-O
having VERB B-O
1 NUM B-O
or CCONJ B-O
more ADJ B-O
chronic ADJ B-O
conditions NOUN B-O
themselves PRON B-O
( PUNCT B-O
adjusted ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
[ X B-O
aOR PROPN B-AC
] X B-O
= SYM B-O
1.29 NUM B-O
; PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
[ X B-O
95 NUM B-O
% NOUN B-O
CI PROPN B-AC
] X B-O
1.10–1.50 NUM B-O
) PUNCT B-O
. PUNCT B-O

LJD PROPN B-O
was AUX B-O
the DET B-O
Chairman PROPN B-O
of ADP B-O
the DET B-O
National PROPN B-O
Patient PROPN B-O
Safety PROPN B-O
Agency PROPN B-O
( PUNCT B-O
NPSA PROPN B-O
) PUNCT B-O
( PUNCT B-O
2010–2012 NUM B-O
) PUNCT B-O
and CCONJ B-O
is AUX B-O
currently ADV B-O
involved ADJ B-O
in ADP B-O
the DET B-O
programme NOUN B-O
of ADP B-O
research NOUN B-O
associated VERB B-O
with ADP B-O
the DET B-O
National PROPN B-LF
Reporting PROPN I-LF
and CCONJ I-LF
Learning PROPN I-LF
System PROPN I-LF
( PUNCT B-O
NRLS PROPN B-AC
) PUNCT B-O
. PUNCT B-O

He PRON B-O
is AUX B-O
also ADV B-O
the DET B-O
World PROPN B-O
Health PROPN B-O
Organization PROPN B-O
's PART B-O
Patient PROPN B-O
Safety PROPN B-O
Envoy PROPN B-O
. PUNCT B-O

Many ADJ B-O
additional ADJ B-O
milestones NOUN B-O
have AUX B-O
been AUX B-O
reached VERB B-O
, PUNCT B-O
including VERB B-O
the DET B-O
last ADJ B-O
naturally ADV B-O
occurring VERB B-O
isolation NOUN B-O
of ADP B-O
serotype-2 NOUN B-O
WPV PROPN B-AC
in ADP B-O
1999 NUM B-O
, PUNCT B-O
the DET B-O
last ADJ B-O
reported VERB B-O
case NOUN B-O
of ADP B-O
poliomyelitis NOUN B-O
associated VERB B-O
with ADP B-O
serotype-3 NOUN B-O
in ADP B-O
2012 NUM B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
absence NOUN B-O
of ADP B-O
any DET B-O
reported VERB B-O
wild ADJ B-LF
poliovirus NOUN I-LF
type NOUN I-LF
1 NUM I-LF
( PUNCT B-O
WPV1 PROPN B-AC
) PUNCT B-O
cases NOUN B-O
in ADP B-O
Africa PROPN B-O
outside ADP B-O
of ADP B-O
Borno PROPN B-O
, PUNCT B-O
Nigeria PROPN B-O
( PUNCT B-O
which PRON B-O
reported VERB B-O
4 NUM B-O
WPV1 PROPN B-AC
cases NOUN B-O
with ADP B-O
a DET B-O
date NOUN B-O
of ADP B-O
onset NOUN B-O
in ADP B-O
July PROPN B-O
– PUNCT B-O
August PROPN B-O
2016 NUM B-O
and CCONJ B-O
remains VERB B-O
a DET B-O
challenge NOUN B-O
because SCONJ B-O
of ADP B-O
issues NOUN B-O
with ADP B-O
security NOUN B-O
, PUNCT B-O
inaccessibility NOUN B-O
, PUNCT B-O
and CCONJ B-O
weak ADJ B-O
surveillance NOUN B-O
) PUNCT B-O
, PUNCT B-O
since SCONJ B-O
August PROPN B-O
2014 NUM B-O
( PUNCT B-O
in ADP B-O
Somalia PROPN B-O
) PUNCT B-O
. PUNCT B-O

Ex ADJ B-LF
- ADJ I-LF
vivo ADJ I-LF
lung NOUN I-LF
perfusion NOUN I-LF
( PUNCT B-O
EVLP PROPN B-AC
) PUNCT B-O
is AUX B-O
an DET B-O
emerging VERB B-O
technique NOUN B-O
promising VERB B-O
an DET B-O
expansion NOUN B-O
of ADP B-O
the DET B-O
donor NOUN B-O
pool NOUN B-O
and CCONJ B-O
improvements NOUN B-O
in ADP B-O
the DET B-O
outcome NOUN B-O
after ADP B-O
lung NOUN B-O
transplantation NOUN B-O
. PUNCT B-O

These DET B-O
results NOUN B-O
contrast VERB B-O
to ADP B-O
the DET B-O
prevalent ADJ B-O
thought NOUN B-O
that SCONJ B-O
oxygen NOUN B-O
- PUNCT B-O
reactive ADJ B-O
Hbs PROPN B-AC
( PUNCT B-O
HbII NOUN B-O
and CCONJ B-O
HbIII NOUN B-O
) PUNCT B-O
are AUX B-O
widely ADV B-O
distributed VERB B-O
and CCONJ B-O
that SCONJ B-O
the DET B-O
sulfide NOUN B-O
- PUNCT B-O
reactive ADJ B-O
hemoglobin NOUN B-LF
( PUNCT B-O
HbI NOUN B-O
) PUNCT B-O
is AUX B-O
only ADV B-O
present ADJ B-O
in ADP B-O
the DET B-O
tissue NOUN B-O
where SCONJ B-O
the DET B-O
endosymbiont NOUN B-O
is AUX B-O
located VERB B-O
[ X B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

CTRL PROPN B-O
, PUNCT B-O
control NOUN B-O
; PUNCT B-O
EXC PROPN B-O
, PUNCT B-O
excised VERB B-O
; PUNCT B-O
hpi PROPN B-O
, PUNCT B-O
hours NOUN B-O
post NOUN B-O
invasion NOUN B-O
; PUNCT B-O
INT PROPN B-O
, PUNCT B-O
integration NOUN B-O
; PUNCT B-O
n.s PROPN B-O
. PUNCT B-O

, PUNCT B-O
not PART B-O
significant ADJ B-O
by ADP B-O
unpaired ADJ B-O
t NOUN B-O
test NOUN B-O
( PUNCT B-O
p NOUN B-O
- PUNCT B-O
value NOUN B-O
= SYM B-O
0.9895 NUM B-O
) PUNCT B-O
; PUNCT B-O
PDEβ PROPN B-AC
, PUNCT B-O
phosphodiesterase NOUN B-LF
β PUNCT I-LF
; PUNCT B-O
PfPDEβ PROPN B-AC
, PUNCT B-O
Plasmodium NOUN B-LF
falciparum NOUN I-LF
phosphodiesterase NOUN B-LF
β PUNCT I-LF
; PUNCT B-O
RAP PROPN B-AC
, PUNCT B-O
rapamycin NOUN B-LF
; PUNCT B-O
RFU PROPN B-O
, PUNCT B-O
relative ADJ B-O
fluorescence NOUN B-O
unit NOUN B-O
. PUNCT B-O

Additionally ADV B-O
, PUNCT B-O
participants NOUN B-O
reported VERB B-O
that SCONJ B-O
most ADJ B-O
of ADP B-O
the DET B-O
current ADJ B-O
priority NOUN B-O
initiatives NOUN B-O
such ADJ B-O
as ADP B-O
Clean PROPN B-LF
and CCONJ I-LF
Safe PROPN I-LF
Health PROPN I-LF
Facility PROPN I-LF
( PUNCT B-O
CASH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
quality NOUN B-O
movement NOUN B-O
, PUNCT B-O
and CCONJ B-O
Compassionate PROPN B-LF
, PUNCT I-LF
Respectful PROPN I-LF
, PUNCT I-LF
and CCONJ I-LF
Caring PROPN I-LF
( PUNCT B-O
CRC PROPN B-AC
) PUNCT B-O
by ADP B-O
the DET B-O
Federal PROPN B-O
Minstry PROPN B-O
of ADP B-O
Health PROPN B-O
( PUNCT B-O
FMOH PROPN B-O
) PUNCT B-O
could AUX B-O
well ADV B-O
be AUX B-O
complemented VERB B-O
by ADP B-O
the DET B-O
intents NOUN B-O
of ADP B-O
the DET B-O
current ADJ B-O
guideline NOUN B-O
. PUNCT B-O

These DET B-O
cases NOUN B-O
have AUX B-O
deserved VERB B-O
the DET B-O
designation NOUN B-O
of ADP B-O
GT PROPN B-AC
- PUNCT B-O
like ADJ B-O
syndrome NOUN B-O
( PUNCT B-O
GTLS PROPN B-AC
) PUNCT B-O
or CCONJ B-O
ITGA2B PROPN B-LF
/ SYM I-LF
ITGA2B PROPN B-AC
ITGB3 PROPN I-LF
- PUNCT I-LF
ITGB3 PROPN B-AC
related VERB I-LF
thrombocytopenia NOUN I-LF
( PUNCT B-O
ITGA2B PROPN B-AC
) PUNCT B-O
. PUNCT B-O

The DET B-O
first ADJ B-O
description NOUN B-O
dates VERB B-O
to ADP B-O
the DET B-O
1990s NOUN B-O
[ PUNCT B-O
14,15 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
, PUNCT B-O
along ADP B-O
the DET B-O
recent ADJ B-O
years NOUN B-O
, PUNCT B-O
the DET B-O
disease NOUN B-O
has AUX B-O
been AUX B-O
characterized VERB B-O
, PUNCT B-O
with ADP B-O
only ADV B-O
a DET B-O
few ADJ B-O
variants NOUN B-O
being AUX B-O
described VERB B-O
in ADP B-O
the DET B-O
/ITGB3-RTITGA2B PROPN B-AC
and CCONJ B-O
ITGB3 PROPN B-AC
genes NOUN B-O
. PUNCT B-O

Another DET B-O
well ADV B-O
- PUNCT B-O
characterized VERB B-O
CTL PROPN B-AC
epitope NOUN B-O
, PUNCT B-O
from ADP B-O
Sendai PROPN B-LF
virus NOUN I-LF
nucleoprotein NOUN I-LF
( PUNCT B-O
SV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
was AUX B-O
investigated VERB B-O
to PART B-O
provide VERB B-O
further ADJ B-O
evidence NOUN B-O
that SCONJ B-O
-NPTAP PROPN B-AC
over NOUN B-O
- PUNCT B-O
expression NOUN B-O
can AUX B-O
augment VERB B-O
antiviral ADJ B-O
responses NOUN B-O
. PUNCT B-O

Importantly ADV B-O
, PUNCT B-O
caspase-4 NOUN B-O
can AUX B-O
be AUX B-O
activated VERB B-O
by ADP B-O
increased VERB B-O
intracellular ADJ B-O
Ca2 NOUN B-O
+ NOUN B-O
level NOUN B-O
, PUNCT B-O
for ADP B-O
example NOUN B-O
, PUNCT B-O
ER PROPN B-AC
Ca2 NOUN B-O
+ NOUN B-O
release NOUN B-O
mediated VERB B-O
by ADP B-O
transmembrane NOUN B-LF
protein NOUN I-LF
173 NUM I-LF
( PUNCT B-O
TMEM173 PROPN B-AC
) PUNCT B-O
( PUNCT B-O
also ADV B-O
known VERB B-O
as ADP B-O
stimulator NOUN B-LF
of ADP I-LF
interferon NOUN I-LF
genes NOUN I-LF
( PUNCT B-O
STING PROPN B-AC
) PUNCT B-O
) PUNCT B-O
[ X B-O
56 X B-O
] PUNCT B-O
or CCONJ B-O
the DET B-O
SERCA PROPN B-AC
inhibitor NOUN B-O
thapsigargin NOUN B-O
[ X B-O
57 X B-O
] PUNCT B-O
. PUNCT B-O

KO PROPN B-AC
, PUNCT B-O
knockout NOUN B-LF
; PUNCT B-O
mDia1 PROPN B-O
, PUNCT B-O
mammalian ADJ B-O
diaphanous ADJ B-O
homolog1 NOUN B-O
; PUNCT B-O
mDia3 PROPN B-O
, PUNCT B-O
mammalian ADJ B-O
diaphanous ADJ B-O
homolog3 NOUN B-O
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT B-O

Detection NOUN B-O
was AUX B-O
carried VERB B-O
out ADP B-O
in ADP B-O
multiple ADJ B-LF
reactions NOUN I-LF
monitoring NOUN I-LF
( PUNCT B-O
MRM PROPN B-AC
) PUNCT B-O
mode NOUN B-O
. PUNCT B-O

A DET B-O
significant ADJ B-O
independent ADJ B-O
association NOUN B-O
was AUX B-O
found VERB B-O
between ADP B-O
serum ADJ B-O
CysC PROPN B-AC
and CCONJ B-O
GDM PROPN B-AC
in ADP B-O
the DET B-O
binary ADJ B-O
logistic ADJ B-O
regression NOUN B-O
analysis NOUN B-O
after SCONJ B-O
adjusted VERB B-O
for ADP B-O
age NOUN B-O
, PUNCT B-O
BMI PROPN B-AC
, PUNCT B-O
SP PROPN B-AC
, PUNCT B-O
DP PROPN B-AC
, PUNCT B-O
HbA1c PROPN B-AC
, PUNCT B-O
UA PROPN B-AC
, PUNCT B-O
TG PROPN B-AC
and CCONJ B-O
HOMA PROPN B-AC
ratio NOUN I-LF
( PUNCT B-O
-IR[oddsOR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
14.269 NUM B-O
; PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval(CI NOUN I-LF
) PUNCT B-O
, PUNCT B-O
4.977–40.908 NUM B-O
, PUNCT B-O
P<0.001 NUM B-O
] PUNCT B-O
. PUNCT B-O

Clinical ADJ B-O
investigators NOUN B-O
, PUNCT B-O
IRBs PROPN B-AC
, PUNCT B-O
data NOUN B-O
safety NOUN B-O
and CCONJ B-O
monitoring NOUN B-O
boards NOUN B-O
, PUNCT B-O
and CCONJ B-O
regulatory ADJ B-O
agencies NOUN B-O
( PUNCT B-O
e.g. X B-O
, PUNCT B-O
the DET B-O
European PROPN B-LF
Medicines PROPN I-LF
Agency PROPN I-LF
[ PUNCT B-O
EMA PROPN B-AC
] PUNCT B-O
and CCONJ B-O
the DET B-O
Food PROPN B-LF
and CCONJ I-LF
Drug PROPN I-LF
Administration PROPN I-LF
[ PUNCT B-O
FDA PROPN B-AC
] PUNCT B-O
) PUNCT B-O
are AUX B-O
all PRON B-O
charged VERB B-O
with ADP B-O
risk NOUN B-O
– PUNCT B-O
benefit NOUN B-O
assessment NOUN B-O
. PUNCT B-O

RNA-seq PROPN B-AC
, PUNCT B-O
RNA NOUN B-LF
sequencing NOUN I-LF
. PUNCT B-O

Parenteral ADJ B-O
nutrition NOUN B-O
can AUX B-O
be AUX B-O
provided VERB B-O
independently ADV B-O
( PUNCT B-O
total ADJ B-LF
parenteral ADJ I-LF
nutrition NOUN I-LF
, PUNCT B-O
TPN PROPN B-AC
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
be AUX B-O
combined VERB B-O
with ADP B-O
enteral ADJ B-O
nutrition NOUN B-O
. PUNCT B-O

Studies NOUN B-O
in ADP B-O
Drosophila PROPN B-O
have AUX B-O
identified VERB B-O
conserved ADJ B-O
polarity NOUN B-O
factors NOUN B-O
that PRON B-O
define VERB B-O
the DET B-O
apical ADJ B-O
( PUNCT B-O
Crumbs PROPN B-O
, PUNCT B-O
Stardust PROPN B-O
, PUNCT B-O
Par-6 PROPN B-O
, PUNCT B-O
atypical ADJ B-LF
protein NOUN I-LF
kinase NOUN I-LF
C PROPN I-LF
[ X B-O
aPKC PROPN B-AC
] PUNCT B-O
) PUNCT B-O
, PUNCT B-O
junctional ADJ B-O
( PUNCT B-O
Bazooka PROPN B-LF
[ X B-O
Baz]/Par-3 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
basolateral ADJ B-O
( PUNCT B-O
Scribbled VERB B-LF
[ X B-O
Scrib PROPN B-AC
] PUNCT B-O
, PUNCT B-O
Discs NOUN B-LF
large ADJ I-LF
[ X B-O
Dlg PROPN B-AC
] PUNCT B-O
, PUNCT B-O
Lethal ADJ B-O
[ X B-O
2 X B-O
] PUNCT B-O
giant ADJ B-O
larvae NOUN B-O
[ X B-O
Lgl PROPN B-AC
] PUNCT B-O
) PUNCT B-O
domains NOUN B-O
of ADP B-O
epithelial ADJ B-O
cells NOUN B-O
. PUNCT B-O

The DET B-O
prevalence NOUN B-O
of ADP B-O
alcohol NOUN B-LF
use NOUN I-LF
disorder NOUN I-LF
( PUNCT B-O
AUD PROPN B-AC
) PUNCT B-O
was AUX B-O
14.2 NUM B-O
% PUNCT B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
wtBMMΦ PROPN B-AC
and CCONJ B-O
wtBMDCs PROPN B-AC
secrete VERB B-O
IFNα PROPN B-O
after ADP B-O
MNV-1 PROPN B-AC
- PUNCT B-O
infection NOUN B-O
, PUNCT B-O
as SCONJ B-O
determined VERB B-O
by ADP B-O
IFNα PROPN B-O
enzyme NOUN B-LF
- PUNCT I-LF
linked VERB I-LF
immunosorbent ADJ I-LF
assay NOUN I-LF
( PUNCT B-O
ELISA PROPN B-AC
) PUNCT B-O
( PUNCT B-O
data NOUN B-O
not PART B-O
shown VERB B-O
) PUNCT B-O
. PUNCT B-O

Resource NOUN B-LF
utilization NOUN I-LF
groups NOUN I-LF
( PUNCT B-O
RUGs PROPN B-AC
) PUNCT B-O
were AUX B-O
introduced VERB B-O
as ADP B-O
the DET B-O
way NOUN B-O
per X B-O
diem X B-O
prospective ADJ B-O
payments NOUN B-O
are AUX B-O
set VERB B-O
for ADP B-O
Medicare PROPN B-O
- PUNCT B-O
reimbursed VERB B-O
SNF PROPN B-AC
care NOUN B-O
, PUNCT B-O
classifying VERB B-O
patients NOUN B-O
into ADP B-O
reimbursement NOUN B-O
categories NOUN B-O
based VERB B-O
on ADP B-O
rehabilitation NOUN B-O
service NOUN B-O
use NOUN B-O
: PUNCT B-O
ultra ADJ B-O
( PUNCT B-O
720 NUM B-O
+ NUM B-O
minutes NOUN B-O
/ SYM B-O
week NOUN B-O
) PUNCT B-O
, PUNCT B-O
very ADV B-O
high ADJ B-O
( PUNCT B-O
500–719 NUM B-O
) PUNCT B-O
, PUNCT B-O
high ADJ B-O
( PUNCT B-O
325–499 NUM B-O
) PUNCT B-O
, PUNCT B-O
medium ADJ B-O
( PUNCT B-O
150–324 NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
low ADJ B-O
( PUNCT B-O
45–149 NUM B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
each DET B-O
country NOUN B-O
we PRON B-O
sought VERB B-O
published VERB B-O
and CCONJ B-O
unpublished ADJ B-O
documents NOUN B-O
( PUNCT B-O
situation NOUN B-O
reports NOUN B-O
, PUNCT B-O
official ADJ B-O
statistics NOUN B-O
, PUNCT B-O
evaluation NOUN B-O
reports NOUN B-O
, PUNCT B-O
technical ADJ B-O
documents NOUN B-O
, PUNCT B-O
guidelines NOUN B-O
for ADP B-O
victim NOUN B-O
identification NOUN B-O
, PUNCT B-O
and CCONJ B-O
public ADJ B-O
health NOUN B-O
reports NOUN B-O
) PUNCT B-O
from ADP B-O
national ADJ B-O
ministries NOUN B-O
of ADP B-O
health NOUN B-O
and CCONJ B-O
government NOUN B-O
offices NOUN B-O
, PUNCT B-O
the DET B-O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WHO PROPN B-AC
) PUNCT B-O
, PUNCT B-O
non ADJ B-O
- ADJ B-O
governmental ADJ B-O
organisations NOUN B-O
, PUNCT B-O
and CCONJ B-O
voluntary ADJ B-O
groups NOUN B-O
. PUNCT B-O

Immunofluorescence NOUN B-O
with ADP B-O
antibodies NOUN B-O
to ADP B-O
the DET B-O
myelin NOUN B-O
protein NOUN B-O
, PUNCT B-O
myelin NOUN B-LF
oligodendrocyte NOUN I-LF
glycoprotein NOUN I-LF
( PUNCT B-O
MOG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
confirmed VERB B-O
the DET B-O
myelin NOUN B-O
integrity NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1A NUM B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
HLA PROPN B-O
- ADJ B-O
DR PROPN B-O
( PUNCT B-O
MHC PROPN B-O
class NOUN B-O
II NUM B-O
) PUNCT B-O
antibodies NOUN B-O
confirmed VERB B-O
the DET B-O
presence NOUN B-O
of ADP B-O
microglia NOUN B-O
with ADP B-O
an DET B-O
activated VERB B-O
morphology NOUN B-O
( PUNCT B-O
thicker ADJ B-O
and CCONJ B-O
shorter ADJ B-O
processes NOUN B-O
) PUNCT B-O
( PUNCT B-O
Fig PROPN B-O
1B NUM B-O
) PUNCT B-O
. PUNCT B-O

Immunofluorescence NOUN B-O
for ADP B-O
Caspr1 PROPN B-O
localised VERB B-O
at ADP B-O
the DET B-O
paranodes NOUN B-O
demonstrated VERB B-O
that SCONJ B-O
Caspr1 PROPN B-O
- ADJ B-O
stained VERB B-O
paranodes NOUN B-O
( PUNCT B-O
2.8 NUM B-O
± SYM B-O
1.1 NUM B-O
μm NOUN B-O
) PUNCT B-O
were AUX B-O
significantly ADV B-O
21.7 NUM B-O
% NOUN B-O
longer ADJ B-O
on ADP B-O
average ADJ B-O
in ADP B-O
the DET B-O
MS PROPN B-AC
NAWM PROPN B-AC
tissue NOUN B-O
than ADP B-O
in ADP B-O
the DET B-O
non ADJ B-O
- ADJ B-O
neurological ADJ B-O
control NOUN B-O
tissue NOUN B-O
( PUNCT B-O
2.3 NUM B-O
± SYM B-O
0.8μm NUM B-O
, PUNCT B-O
Fig PROPN B-O
1C–1 NUM B-O
G PROPN B-O
) PUNCT B-O
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
43 NUM B-O
% NOUN B-O
of ADP B-O
the DET B-O
paranodes NOUN B-O
in ADP B-O
the DET B-O
MS PROPN B-AC
tissue NOUN B-O
were AUX B-O
longer ADJ B-O
than ADP B-O
the DET B-O
75 NUM B-O
% NOUN B-O
percentile NOUN B-O
of ADP B-O
the DET B-O
control NOUN B-O
group NOUN B-O
( PUNCT B-O
2.7 NUM B-O
μm NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
11.14 NUM B-O
% NOUN B-O
were AUX B-O
longer ADJ B-O
than ADP B-O
4 NUM B-O
μm NOUN B-O
, PUNCT B-O
compared VERB B-O
to ADP B-O
the DET B-O
4.1 NUM B-O
% NOUN B-O
in ADP B-O
the DET B-O
non ADJ B-O
- ADJ B-O
neurological ADJ B-O
controls NOUN B-O
( PUNCT B-O
Fig PROPN B-O
1 NUM B-O
G PROPN B-O
) PUNCT B-O
. PUNCT B-O

There PRON B-O
was VERB B-O
little ADJ B-O
difference NOUN B-O
between ADP B-O
the DET B-O
2 NUM B-O
brain NOUN B-O
areas NOUN B-O
examined VERB B-O
; PUNCT B-O
the DET B-O
paranodal ADJ B-O
lengths NOUN B-O
in ADP B-O
the DET B-O
cerebral ADJ B-O
peduncles NOUN B-O
of ADP B-O
the DET B-O
mesencephalon NOUN B-O
were AUX B-O
2.81 NUM B-O
± SYM B-O
0.019 NUM B-O
μm NOUN B-O
long ADJ B-O
, PUNCT B-O
and CCONJ B-O
12 NUM B-O
% NOUN B-O
of ADP B-O
them PRON B-O
were AUX B-O
> ADP B-O
4 NUM B-O
μm NOUN B-O
, PUNCT B-O
compared VERB B-O
to ADP B-O
those PRON B-O
in ADP B-O
the DET B-O
precentral ADJ B-O
gyrus NOUN B-O
, PUNCT B-O
which PRON B-O
were AUX B-O
2.79 NUM B-O
± SYM B-O
0.017 NUM B-O
μm NOUN B-O
long ADJ B-O
, PUNCT B-O
and CCONJ B-O
10 NUM B-O
% NOUN B-O
of ADP B-O
them PRON B-O
were AUX B-O
> ADP B-O
4 NUM B-O
μm NOUN B-O
( PUNCT B-O
S1 PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

Class NOUN B-O
B NOUN B-O
enzymes NOUN B-O
are AUX B-O
zinc NOUN B-O
dependent ADJ B-O
metallo NOUN B-LF
- PUNCT I-LF
β PUNCT I-LF
- PUNCT I-LF
lactamases NOUN I-LF
( PUNCT B-O
MBLs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
require VERB B-O
one NUM B-O
or CCONJ B-O
two NUM B-O
Zn2 NOUN B-O
+ NOUN B-O
in ADP B-O
their PRON B-O
active ADJ B-O
site NOUN B-O
for ADP B-O
catalysis NOUN B-O
[ PUNCT B-O
3 NUM B-O
, PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
the DET B-O
present ADJ B-O
study NOUN B-O
, PUNCT B-O
we PRON B-O
chose VERB B-O
to PART B-O
investigate VERB B-O
this PRON B-O
using VERB B-O
two NUM B-O
different ADJ B-O
kinds NOUN B-O
of ADP B-O
spatial ADJ B-O
memory NOUN B-O
tests NOUN B-O
: PUNCT B-O
the DET B-O
spontaneous ADJ B-LF
place NOUN I-LF
recognition NOUN I-LF
( PUNCT B-O
SPR PROPN B-AC
) PUNCT B-O
test NOUN B-O
and CCONJ B-O
the DET B-O
delay NOUN B-LF
- PUNCT I-LF
interposed VERB I-LF
radial ADJ I-LF
arm NOUN I-LF
maze NOUN I-LF
( PUNCT B-O
dRAM PROPN B-AC
) PUNCT B-O
task NOUN B-O
. PUNCT B-O

For ADP B-O
EM PROPN B-AC
studies NOUN B-O
, PUNCT B-O
MRC5 PROPN B-O
cells NOUN B-O
were AUX B-O
infected VERB B-O
at ADP B-O
an DET B-O
m.o.i NOUN B-O
. PUNCT B-O

of ADP B-O
5 NUM B-O
as SCONJ B-O
described VERB B-O
above ADV B-O
and CCONJ B-O
fixed VERB B-O
in ADP B-O
situ NOUN B-O
by ADP B-O
incubation NOUN B-O
for ADP B-O
48 NUM B-O
h NOUN B-O
in ADP B-O
4 NUM B-O
% NOUN B-O
PFA NOUN B-O
and CCONJ B-O
1 NUM B-O
% NOUN B-O
glutaraldehyde NOUN B-O
in ADP B-O
0.1 NUM B-O
M PROPN B-O
phosphate NOUN B-O
buffer NOUN B-O
( PUNCT B-O
pH NOUN B-O
7.2 NUM B-O
) PUNCT B-O
; PUNCT B-O
they PRON B-O
were AUX B-O
then ADV B-O
post VERB B-O
- VERB B-O
fixed VERB B-O
by ADP B-O
incubation NOUN B-O
for ADP B-O
1 NUM B-O
h NOUN B-O
with ADP B-O
2 NUM B-O
% NOUN B-O
osmium NOUN B-O
tetroxide NOUN B-O
( PUNCT B-O
Electron PROPN B-LF
Microscopy PROPN I-LF
Science PROPN B-O
, PUNCT B-O
http://www.emsdiasum.com X B-O
) PUNCT B-O
. PUNCT B-O

Timely ADV B-O
and CCONJ B-O
an PRON B-O
accurate ADJ B-O
risk NOUN B-O
stratification NOUN B-O
of ADP B-O
patients NOUN B-O
in ADP B-O
the DET B-O
emergency NOUN B-LF
department NOUN I-LF
( PUNCT B-O
ED PROPN B-AC
) PUNCT B-O
supports VERB B-O
the DET B-O
clinician NOUN B-O
in ADP B-O
reducing VERB B-O
time NOUN B-O
to ADP B-O
effective ADJ B-O
treatment NOUN B-O
— PUNCT B-O
a DET B-O
key ADJ B-O
predictor NOUN B-O
for ADP B-O
patient NOUN B-O
outcome NOUN B-O
. PUNCT B-O

HL PROPN B-AC
: PUNCT B-O
hyperlipidemia NOUN B-LF
Statistical ADJ B-O
analyses NOUN B-O
were AUX B-O
performed VERB B-O
using VERB B-O
logistic ADJ B-O
regression NOUN B-O
and CCONJ B-O
results NOUN B-O
were AUX B-O
reported VERB B-O
as ADP B-O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT B-O
OR PROPN B-AC
) PUNCT B-O
and CCONJ B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-O
interval NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
CI NOUN B-O
) PUNCT B-O
. PUNCT B-O

HBV PROPN B-AC
, PUNCT B-O
hepatitis NOUN B-LF
B PROPN I-LF
virus NOUN I-LF
; PUNCT B-O
HDV PROPN B-AC
, PUNCT B-O
hepatitis NOUN B-LF
D PROPN I-LF
virus NOUN I-LF
. PUNCT B-O

Each DET B-O
green ADJ B-O
dot NOUN B-O
represents VERB B-O
a DET B-O
metabolic ADJ B-O
trait NOUN B-O
and CCONJ B-O
the DET B-O
positions NOUN B-O
of ADP B-O
the DET B-O
dots NOUN B-O
are AUX B-O
determined VERB B-O
by ADP B-O
difference NOUN B-O
in ADP B-O
mean ADJ B-O
offspring NOUN B-O
metabolite NOUN B-O
( PUNCT B-O
in ADP B-O
SD NOUN B-O
units NOUN B-O
) PUNCT B-O
for ADP B-O
each DET B-O
increase NOUN B-O
of ADP B-O
1 NUM B-O
- NOUN B-O
SD NOUN B-O
maternal ADJ B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI PROPN B-AC
) PUNCT B-O
( PUNCT B-O
x NOUN B-O
- NOUN B-O
axis NOUN B-O
) PUNCT B-O
and CCONJ B-O
difference NOUN B-O
in ADP B-O
mean ADJ B-O
offspring NOUN B-O
metabolite NOUN B-O
( PUNCT B-O
in ADP B-O
SD NOUN B-O
units NOUN B-O
) PUNCT B-O
for ADP B-O
each DET B-O
increase NOUN B-O
in ADP B-O
1 NUM B-O
- NOUN B-O
SD NOUN B-O
paternal ADJ B-O
BMI PROPN B-AC
( PUNCT B-O
y NOUN B-O
- NOUN B-O
axis NOUN B-O
) PUNCT B-O
. PUNCT B-O

Acute ADJ B-LF
gastroenteritis NOUN I-LF
( PUNCT B-O
AGE PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
common ADJ B-O
condition NOUN B-O
that PRON B-O
imposes VERB B-O
a DET B-O
significant ADJ B-O
burden NOUN B-O
on ADP B-O
communities NOUN B-O
and CCONJ B-O
healthcare NOUN B-O
systems NOUN B-O
worldwide ADV B-O
. PUNCT B-O

We PRON B-O
developed VERB B-O
and CCONJ B-O
validated VERB B-O
a DET B-O
computational ADJ B-O
model NOUN B-O
of ADP B-O
signal NOUN B-LF
transducer NOUN I-LF
and CCONJ I-LF
activator NOUN I-LF
of ADP I-LF
transcription-3 NOUN I-LF
( PUNCT B-O
Stat3 PROPN B-AC
) PUNCT B-O
pathway NOUN B-O
kinetics NOUN B-O
, PUNCT B-O
a DET B-O
signaling NOUN B-O
network NOUN B-O
involved VERB B-O
in ADP B-O
embryonic ADJ B-O
stem NOUN B-O
cell NOUN B-O
( PUNCT B-O
ESC PROPN B-AC
) PUNCT B-O
self NOUN B-O
- PUNCT B-O
renewal NOUN B-O
. PUNCT B-O

Electrophoretic ADJ B-LF
mobility NOUN I-LF
shift NOUN I-LF
assays NOUN I-LF
( PUNCT B-O
EMSAs PROPN B-AC
) PUNCT B-O
were AUX B-O
performed VERB B-O
using VERB B-O
the DET B-O
Lightshift PROPN B-O
chemi NOUN B-O
- PUNCT B-O
luminescence NOUN B-O
EMSA PROPN B-AC
kit NOUN B-O
( PUNCT B-O
Pierce PROPN B-O
) PUNCT B-O
according VERB B-O
to ADP B-O
the DET B-O
manufacturer NOUN B-O
’s PART B-O
instructions NOUN B-O
described VERB B-O
in ADP B-O
[ X B-O
65 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
average NOUN B-O
of ADP B-O
3 NUM B-O
blood NOUN B-LF
pressures NOUN I-LF
( PUNCT B-O
BP PROPN B-AC
) PUNCT B-O
taken VERB B-O
5 NUM B-O
minutes NOUN B-O
apart ADV B-O
were AUX B-O
used VERB B-O
. PUNCT B-O

Almost ADV B-O
all PRON B-O
women NOUN B-O
recruited VERB B-O
in ADP B-O
both DET B-O
study NOUN B-O
groups NOUN B-O
used VERB B-O
their PRON B-O
allocated VERB B-O
study NOUN B-O
treatment NOUN B-O
( PUNCT B-O
381 NUM B-O
[ X B-O
95.7 NUM B-O
% NOUN B-O
] PUNCT B-O
in ADP B-O
the DET B-O
progesterone NOUN B-O
group NOUN B-O
and CCONJ B-O
359 NUM B-O
[ X B-O
92.3 NUM B-O
% NOUN B-O
] PUNCT B-O
in ADP B-O
the DET B-O
placebo NOUN B-O
group NOUN B-O
) PUNCT B-O
, PUNCT B-O
with ADP B-O
similar ADJ B-O
median ADJ B-O
days NOUN B-O
of ADP B-O
use NOUN B-O
in ADP B-O
both DET B-O
study NOUN B-O
groups NOUN B-O
( PUNCT B-O
51.0 NUM B-O
days NOUN B-O
[ X B-O
interquartile ADJ B-LF
range NOUN I-LF
( PUNCT B-O
IQR PROPN B-AC
) PUNCT B-O
28.0–69.0 NUM B-O
] PUNCT B-O
in ADP B-O
the DET B-O
progesterone NOUN B-O
group NOUN B-O
versus ADP B-O
52.0 NUM B-O
days NOUN B-O
[ X B-O
IQR PROPN B-AC
27.0–76.0 NUM B-O
] PUNCT B-O
in ADP B-O
the DET B-O
placebo NOUN B-O
group NOUN B-O
) PUNCT B-O
( PUNCT B-O
Table PROPN B-O
1 NUM B-O
) PUNCT B-O
. PUNCT B-O

As SCONJ B-O
shown VERB B-O
in ADP B-O
S5 NUM B-O
Fig PROPN B-O
, PUNCT B-O
and CCONJ B-O
consistent ADJ B-O
with ADP B-O
our PRON B-O
previous ADJ B-O
results NOUN B-O
, PUNCT B-O
ectopic ADJ B-O
induction NOUN B-O
of ADP B-O
all DET B-O
three NUM B-O
Su(H NOUN B-O
) PUNCT B-O
mutants NOUN B-O
in ADP B-O
the DET B-O
eye NOUN B-O
imaginal ADJ B-O
discs NOUN B-O
effects VERB B-O
eye NOUN B-O
morphology NOUN B-O
indistinguishable ADJ B-O
from ADP B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
Su(H NOUN B-O
) PUNCT B-O
, PUNCT B-O
but CCONJ B-O
the DET B-O
triple ADJ B-O
mutants NOUN B-O
Su(H)LLL PROPN B-AC
/ NOUN B-O
AAA NOUN B-O
and CCONJ B-O
Su(H)LLF PROPN B-AC
/ NOUN B-O
AAA NOUN B-O
retain VERB B-O
little ADJ B-O
to PART B-O
no PRON B-O
binding NOUN B-O
of ADP B-O
Hairless PROPN B-LF
in ADP B-O
vivo ADJ B-O
. PUNCT B-O

This PRON B-O
is AUX B-O
fully ADV B-O
restored VERB B-O
in ADP B-O
Dble::R6/2 PROPN B-O
mice NOUN B-O
at ADP B-O
12 NUM B-O
wk NOUN B-O
of ADP B-O
age NOUN B-O
. PUNCT B-O

( PUNCT B-O
K NOUN B-O
) PUNCT B-O
Representative ADJ B-O
traces NOUN B-O
of ADP B-O
miniature ADJ B-LF
EPSCs NOUN I-LF
EPSCs PROPN B-AC
( PUNCT B-O
mEPSCs PROPN B-AC
) PUNCT B-O
at ADP B-O
8 NUM B-O
wk NOUN B-O
. PUNCT B-O

Status NOUN B-O
of ADP B-O
promoter NOUN B-O
region NOUN B-O
methylation NOUN B-O
of ADP B-O
O6 NOUN B-O
- PUNCT B-O
methylguanine NOUN B-O
DNA NOUN B-O
methyltransferase NOUN B-O
( PUNCT B-O
MGMT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Isocitrate NOUN B-LF
dehydrogenase NOUN I-LF
1 NUM B-O
and CCONJ B-O
2 NUM B-O
( PUNCT B-O
IDH PROPN B-AC
1/2 NUM B-O
) PUNCT B-O
mutations NOUN B-O
were AUX B-O
also ADV B-O
assessed VERB B-O
. PUNCT B-O

The DET B-O
included VERB B-O
literature NOUN B-O
fulfilled VERB B-O
the DET B-O
following ADJ B-O
criteria NOUN B-O
: PUNCT B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
The DET B-O
case NOUN B-O
- PUNCT B-O
control NOUN B-O
studies NOUN B-O
or CCONJ B-O
cohort NOUN B-O
designs NOUN B-O
on ADP B-O
the DET B-O
correlation NOUN B-O
between ADP B-O
the DET B-O
polymorphism NOUN B-O
of ADP B-O
ADIPOQ NOUN B-O
gene NOUN B-O
rs2241766 NOUN B-O
or CCONJ B-O
rs1501299 NOUN B-O
and CCONJ B-O
T2DM PROPN B-AC
. PUNCT B-O

( PUNCT B-O
2 X B-O
) PUNCT B-O
The DET B-O
genotype NOUN B-O
distribution NOUN B-O
conformed VERB B-O
to ADP B-O
the DET B-O
HWE PROPN B-AC
( PUNCT B-O
Hardy PROPN B-LF
- PUNCT I-LF
Weinberg PROPN I-LF
Equilibrium PROPN I-LF
) PUNCT B-O
balance NOUN B-O
in ADP B-O
the DET B-O
control NOUN B-O
population NOUN B-O
. PUNCT B-O

( PUNCT B-O
3 X B-O
) PUNCT B-O
The DET B-O
genotype NOUN B-O
frequency NOUN B-O
, PUNCT B-O
the DET B-O
odds NOUN B-LF
ratio NOUN I-LF
( PUNCT B-O
OR PROPN B-AC
) PUNCT B-O
value NOUN B-O
, PUNCT B-O
or CCONJ B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT B-O
CI PROPN B-AC
) PUNCT B-O
were AUX B-O
directly ADV B-O
given VERB B-O
in ADP B-O
the DET B-O
literature NOUN B-O
. PUNCT B-O

( PUNCT B-O
4 X B-O
) PUNCT B-O
The DET B-O
language NOUN B-O
of ADP B-O
the DET B-O
literature NOUN B-O
was AUX B-O
Chinese PROPN B-O
or CCONJ B-O
English PROPN B-O
. PUNCT B-O

( PUNCT B-O
5 X B-O
) PUNCT B-O
For ADP B-O
multiple ADJ B-O
studies NOUN B-O
of ADP B-O
the DET B-O
same ADJ B-O
author NOUN B-O
, PUNCT B-O
the DET B-O
latest ADJ B-O
study NOUN B-O
or CCONJ B-O
that SCONJ B-O
with ADP B-O
sufficient ADJ B-O
data NOUN B-O
was AUX B-O
selected VERB B-O
. PUNCT B-O

The DET B-O
median ADJ B-O
age NOUN B-O
was AUX B-O
45 NUM B-O
years NOUN B-O
( PUNCT B-O
interquartile ADJ B-LF
range NOUN I-LF
( PUNCT B-O
IQR PROPN B-AC
) PUNCT B-O
38–54 NUM B-O
) PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
MACEs PROPN B-AC
: PUNCT B-O
major ADJ B-LF
adverse ADJ I-LF
cardiac ADJ I-LF
events NOUN I-LF
, PUNCT B-O
MI PROPN B-O
: PUNCT B-O
myocardial ADJ B-O
infarction NOUN B-O
, PUNCT B-O
TLR NOUN B-O
: PUNCT B-O
target NOUN B-O
lesion NOUN B-O
revascularization NOUN B-O
, PUNCT B-O
TVR NOUN B-O
: PUNCT B-O
target NOUN B-O
vessel NOUN B-O
revascularization NOUN B-O
, PUNCT B-O
ST NOUN B-O
: PUNCT B-O
stent NOUN B-O
thrombosis NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
ER PROPN B-AC
, PUNCT B-O
estrogen NOUN B-LF
receptor NOUN I-LF
; PUNCT B-O
PR PROPN B-AC
, PUNCT B-O
progesterone NOUN B-LF
receptor NOUN I-LF
; PUNCT B-O
HER2 PROPN B-O
, PUNCT B-O
Human PROPN B-O
epidermal ADJ B-O
growth NOUN B-O
factor NOUN B-O
receptor NOUN B-O
2 NUM B-O
; PUNCT B-O
FSH PROPN B-O
, PUNCT B-O
follicle NOUN B-O
stimulating VERB B-O
hormone NOUN B-O
; PUNCT B-O
AST PROPN B-AC
, PUNCT B-O
aspartate NOUN B-LF
aminotransferase NOUN I-LF
; PUNCT B-O
ALT PROPN B-AC
, PUNCT B-O
alanine NOUN B-LF
aminotransferase NOUN I-LF
; PUNCT B-O
HDL PROPN B-O
, PUNCT B-O
high ADJ B-O
- PUNCT B-O
density NOUN B-O
lipoprotein NOUN B-O
; PUNCT B-O
LDL NOUN B-O
, PUNCT B-O
low ADJ B-O
- PUNCT B-O
density NOUN B-O
lipoprotein NOUN B-O
; PUNCT B-O
NFS PROPN B-O
, PUNCT B-O
nonalcoholic ADJ B-O
fatty ADJ B-O
liver NOUN B-O
disease NOUN B-O
fibrosis NOUN B-O
score NOUN B-O
; PUNCT B-O
FIB-4 NOUN B-O
, PUNCT B-O
fibrosis-4 NOUN B-O
; PUNCT B-O
CT PROPN B-AC
, PUNCT B-O
computed VERB B-LF
tomography NOUN I-LF
. PUNCT B-O

Worldwide ADV B-O
, PUNCT B-O
HPVs PROPN B-AC
are AUX B-O
known VERB B-O
to PART B-O
be AUX B-O
one NUM B-O
of ADP B-O
the DET B-O
most ADV B-O
common ADJ B-O
Sexually ADV B-LF
Transmitted VERB I-LF
Infections NOUN I-LF
( PUNCT B-O
STIs PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Diet NOUN B-O
was AUX B-O
assessed VERB B-O
using VERB B-O
the DET B-O
FAST PROPN B-AC
( PUNCT B-O
Food PROPN B-LF
Assessment PROPN I-LF
in ADP I-LF
Schools PROPN I-LF
Tool PROPN I-LF
) PUNCT B-O
food NOUN B-O
diary NOUN B-O
method NOUN B-O
, PUNCT B-O
a DET B-O
method NOUN B-O
validated VERB B-O
for ADP B-O
use NOUN B-O
in ADP B-O
young ADJ B-O
children NOUN B-O
[ PUNCT B-O
14 NUM B-O
] PUNCT B-O
. PUNCT B-O

BMI PROPN B-AC
was AUX B-O
also ADV B-O
determined VERB B-O
according VERB B-O
to PART B-O
the DET B-O
International PROPN B-O
Obesity PROPN B-O
Task PROPN B-O
Force PROPN B-O
( PUNCT B-O
IOTF PROPN B-AC
) PUNCT B-O
and CCONJ B-O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WHO PROPN B-AC
) PUNCT B-O
criteria NOUN B-O
: PUNCT B-O
Thin ADJ B-O
< NUM B-O
5th ADJ B-O
centiles NOUN B-O
; PUNCT B-O
normal ADJ B-O
5th ADJ B-O
to PART B-O
< NUM B-O
85th ADJ B-O
centiles NOUN B-O
; PUNCT B-O
overweight ADJ B-O
85th ADJ B-O
to PART B-O
< NUM B-O
95th ADJ B-O
centiles NOUN B-O
; PUNCT B-O
obese ADJ B-O
95th ADJ B-O
to PART B-O
< NUM B-O
98th ADJ B-O
centiles NOUN B-O
; PUNCT B-O
and CCONJ B-O
extremely ADV B-O
- ADJ B-O
obese ADJ B-O
≥98th ADJ B-O
centiles NOUN B-O
[ PUNCT B-O
13 NUM B-O
] PUNCT B-O
. PUNCT B-O

ECRL PROPN B-O
, PUNCT B-O
extensor NOUN B-O
carpi X B-O
radialis X B-O
longus X B-O
; PUNCT B-O
EEG PROPN B-AC
, PUNCT B-O
electroencephalography NOUN B-LF
; PUNCT B-O
EMG PROPN B-AC
, PUNCT B-O
electromyography NOUN B-LF
. PUNCT B-O

Plasma NOUN B-O
interleukin-6 NOUN B-LF
( PUNCT B-O
IL-6 PROPN B-AC
) PUNCT B-O
levels NOUN B-O
were AUX B-O
quantitated VERB B-O
using VERB B-O
the DET B-O
MILLIPLEX PROPN B-O
® PROPN B-O
MAP PROPN B-O
Human PROPN B-O
High ADJ B-O
Sensitivity PROPN B-O
T PROPN B-O
Cell PROPN B-O
Magnetic PROPN B-O
Bead PROPN B-O
Panel PROPN B-O
immunoassay NOUN B-O
( PUNCT B-O
Merck PROPN B-O
KGaA PROPN B-O
, PUNCT B-O
Darmstadt PROPN B-O
, PUNCT B-O
Germany PROPN B-O
) PUNCT B-O
. PUNCT B-O

After ADP B-O
staining VERB B-O
polytene NOUN B-O
chromosomes NOUN B-O
from ADP B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
larvae NOUN B-O
with ADP B-O
antibodies NOUN B-O
against ADP B-O
ISWI PROPN B-AC
and CCONJ B-O
the DET B-O
elongating VERB B-O
form NOUN B-O
of ADP B-O
Pol PROPN B-AC
( PUNCT B-O
Pol PROPN B-O
IIoser2 PROPN B-O
) PUNCT B-O
, PUNCT B-O
the DET B-O
positions NOUN B-O
of ADP B-O
potential ADJ B-O
target NOUN B-O
genes NOUN B-O
were AUX B-O
identified VERB B-O
by ADP B-O
fluorescent ADJ B-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
( PUNCT B-O
IIFISH PROPN B-AC
; PUNCT B-O
Figure PROPN B-O
3C NUM B-O
and CCONJ B-O
3D NOUN B-O
) PUNCT B-O
. PUNCT B-O

For ADP B-O
these DET B-O
experiments NOUN B-O
, PUNCT B-O
we PRON B-O
selected VERB B-O
genes NOUN B-O
that PRON B-O
exhibited VERB B-O
at ADP B-O
least ADJ B-O
a DET B-O
2.5 ADJ B-O
- PUNCT B-O
fold ADJ B-O
change NOUN B-O
in ADP B-O
gene NOUN B-O
expression NOUN B-O
in ADP B-O
Iswi PROPN B-O
mutant ADJ B-O
versus ADP B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
male NOUN B-O
larvae NOUN B-O
. PUNCT B-O

This PRON B-O
resulted VERB B-O
in ADP B-O
excluding VERB B-O
an DET B-O
average ADJ B-O
number NOUN B-O
of ADP B-O
voxels NOUN B-O
equal ADJ B-O
to ADP B-O
16.2 NUM B-O
% NOUN B-O
of ADP B-O
the DET B-O
region NOUN B-LF
EVC PROPN B-AC
of ADP I-LF
interest NOUN I-LF
( PUNCT B-O
ROI PROPN B-AC
; PUNCT B-O
range NOUN B-O
7.23%–31.55 NUM B-O
% NOUN B-O
across ADP B-O
participants NOUN B-O
) PUNCT B-O
. PUNCT B-O

Tissue NOUN B-O
advanced ADJ B-LF
glycation NOUN I-LF
end NOUN I-LF
product NOUN I-LF
( PUNCT B-O
AGE PROPN B-AC
) PUNCT B-O
accumulation NOUN B-O
has AUX B-O
been AUX B-O
proposed VERB B-O
as ADP B-O
a DET B-O
marker NOUN B-O
of ADP B-O
cumulative ADJ B-O
metabolic ADJ B-O
stress NOUN B-O
that PRON B-O
can AUX B-O
be AUX B-O
assessed VERB B-O
noninvasively ADV B-O
by ADP B-O
measurement NOUN B-O
of ADP B-O
skin NOUN B-LF
autofluorescence NOUN I-LF
( PUNCT B-O
SAF PROPN B-AC
) PUNCT B-O
. PUNCT B-O

In ADP B-O
persons NOUN B-O
on ADP B-O
haemodialysis NOUN B-O
, PUNCT B-O
SAF PROPN B-AC
is AUX B-O
an DET B-O
independent ADJ B-O
risk NOUN B-O
factor NOUN B-O
for ADP B-O
cardiovascular ADJ B-LF
events NOUN I-LF
( PUNCT B-O
CVEs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
all DET B-LF
- PUNCT I-LF
cause NOUN I-LF
mortality NOUN I-LF
( PUNCT B-O
ACM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
but CCONJ B-O
data NOUN B-O
at ADP B-O
earlier ADJ B-O
stages NOUN B-O
of ADP B-O
chronic ADJ B-LF
kidney NOUN I-LF
disease NOUN I-LF
( PUNCT B-O
CKD PROPN B-AC
) PUNCT B-O
are AUX B-O
inconclusive ADJ B-O
. PUNCT B-O

If SCONJ B-O
the DET B-O
systolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
( PUNCT B-O
SBP PROPN B-AC
) PUNCT B-O
or CCONJ B-O
diastolic ADJ B-LF
blood NOUN I-LF
pressure NOUN I-LF
( PUNCT B-O
DBP PROPN B-AC
) PUNCT B-O
exceeded VERB B-O
140 NUM B-O
mmHg NOUN B-O
or CCONJ B-O
90 NUM B-O
mmHg NOUN B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
the DET B-O
measurement NOUN B-O
was AUX B-O
repeated VERB B-O
after ADP B-O
5 NUM B-O
min NOUN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
results NOUN B-O
were AUX B-O
averaged VERB B-O
. PUNCT B-O

The DET B-O
largest ADJ B-O
cluster NOUN B-O
( PUNCT B-O
# PUNCT B-O
0 NUM B-O
) PUNCT B-O
has VERB B-O
16 NUM B-O
members NOUN B-O
, PUNCT B-O
a DET B-O
silhouette NOUN B-O
value NOUN B-O
of ADP B-O
0.789 NUM B-O
and CCONJ B-O
is AUX B-O
labeled VERB B-O
as ADP B-O
carcinogenic ADJ B-O
aristolochic ADJ B-O
acid NOUN B-O
by ADP B-O
LLR PROPN B-AC
( PUNCT B-O
log ADJ B-LF
- PUNCT I-LF
likelihood NOUN I-LF
ratio NOUN I-LF
) PUNCT B-O
. PUNCT B-O

As SCONJ B-O
shown VERB B-O
in ADP B-O
Figure NOUN B-O
1B NUM B-O
, PUNCT B-O
quantitative ADJ B-O
PCR NOUN B-O
experiments NOUN B-O
demonstrated VERB B-O
that SCONJ B-O
β PUNCT B-O