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What is the severity level of interaction between Sparfloxacin and Salbutamol? | Moderate | 441,837 |
Explain the mechanism of interaction between Istradefylline and Cyclosporine. | Others | 688,355 |
What is the interaction between Safinamide and Iloprost? | Monoamine oxidase inhibitors (MAOIs) may potentiate the hypotensive effect of some medications. MAOIs alone quite commonly produce orthostatic hypotension. This effect may stem from a gradual MAOI-induced accumulation of false neurotransmitters in peripheral adrenergic neurons that have minimal activity at alpha- and beta-adrenergic receptors, resulting in a functional block of sympathetic neurotransmission. The interaction has been reported with the concomitant use of beta-blockers. | 951,293 |
What is the interaction between Voriconazole and Hydrocortisone (ophthalmic)? | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations and pharmacologic effects of corticosteroids, which are primarily metabolized by the isoenzyme. The interaction has been reported with potent inhibitors such as clarithromycin, erythromycin, itraconazole, nefazodone, cobicistat, and ritonavir during concomitant use of various corticosteroids, including inhaled, nasal, and ophthalmic formulations. Systemic corticosteroid adverse effects may occur following intensive or long-term continuous ophthalmic corticosteroid therapy. Cushing's syndrome and adrenal insufficiency have been attributed to the interaction.
Arrhythmia ascites AFIB Bacterial infection bleb cerebral haemorrhage confusion dermatitis exfoliative dermatitis medicamentosa allergic dermatitis More | 601,532 |
Explain the mechanism of interaction between Ketamine and Mepyramine. | Synergy | 1,320,693 |
What is the severity level of interaction between Tacrolimus and Doxepin? | Moderate | 804,603 |
How should the interaction between Zolmitriptan and Bromocriptine be managed? Describe the necessary steps. | The concomitant use of two or more 5-HT1 receptor agonists and/or ergotamine-containing or ergot-type medications, or use within 24 hours of each other, is considered contraindicated. | 927,278 |
Explain the mechanism of interaction between Phenytoin and Human rabies virus immune globulin. | Others | 273,797 |
What is the severity level of interaction between Mefloquine and Deutetrabenazine? | Moderate | 172,056 |
What is the severity level of interaction between Cetirizine and Secobarbital? | Moderate | 435,022 |
What is the interaction between Aldesleukin and Mirtazapine? | Sedatives, tranquilizers, muscle relaxants, antidepressants, and other central nervous system (CNS) depressants may have additive CNS-depressant effects with aldesleukin. Aldesleukin has been associated with CNS effects including depression, confusion, and drowsiness, which may progress to coma. | 424,197 |
What is the severity level of interaction between Perphenazine and Brivaracetam? | Moderate | 425,134 |
Explain the mechanism of interaction between Deferasirox and Lurbinectedin. | Metabolism | 332,804 |
How should the interaction between Amifampridine and Promazine be managed? Describe the necessary steps. | Caution is advised if amifampridine is coadministered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with other risk factors for seizures (e.g., head trauma; brain tumor; severe hepatic cirrhosis; metabolic disorders; CNS infections; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; diabetes treated with oral hypoglycemic agents or insulin). | 71,478 |
How should the interaction between Zanubrutinib and Candida albicans be managed? Describe the necessary steps. | Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering diagnostic skin test antigens to patients treated with immunosuppressive agents. | 211,345 |
What is the interaction between Hydrocodone and Estazolam? | Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol) may result in profound sedation, respiratory depression, coma, and death. The risk of hypotension may also be increased with some CNS depressants (e.g., alcohol, benzodiazepines, phenothiazines). | 172,830 |
What is the interaction between Arbutamine and Amoxapine? | Anticholinergic effects, tachycardia and conduction abnormalities associated with tricyclic antidepressant therapy may increase the risk for cardiotoxicity in patients receiving arbutamine for diagnostic purposes. | 1,204,908 |
What is the interaction between Hydralazine and Infliximab? | The risk of peripheral neuropathy may be increased during concurrent use of two or more agents that are associated with this adverse effect. Patient risk factors include diabetes and age older than 60 years. | 1,033,045 |
What is the interaction between Ixabepilone and Pentobarbital? | Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ixabepilone, which is primarily metabolized by the isoenzyme. Subtherapeutic levels of ixabepilone may result. | 326,958 |
Explain the mechanism of interaction between Fostemsavir and Polyethylene glycol (3350). | Synergy | 88,976 |
How should the interaction between Exenatide and Danazol be managed? Describe the necessary steps. | Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages of concomitant antidiabetic agents adjusted as necessary. Patients should be advised to notify their physician if their blood glucose is consistently high or if they experience symptoms of severe hyperglycemia such as excessive thirst and increases in the volume or frequency of urination. | 351,537 |
What is the severity level of interaction between Tranylcypromine and Spironolactone? | Moderate | 34,324 |
How should the interaction between Amphotericin B (cholesteryl sulfate) and Human botulinum neurotoxin A/B immune globulin be managed? Describe the necessary steps. | Intravenous immune globulin preparations should be administered cautiously in patients treated with other potentially nephrotoxic agents (e.g., e.g., aminoglycosides; polypeptide, glycopeptide, and polymyxin antibiotics; amphotericin B; adefovir; cidofovir; tenofovir; foscarnet; cisplatin; deferasirox; gallium nitrate; lithium; mesalamine; certain immunosuppressants; intravenous bisphosphonates; intravenous pentamidine; high intravenous dosages of methotrexate; high dosages and/or chronic use of nonsteroidal anti-inflammatory agents). Clinicians should ensure that patients are not volume depleted prior to the initiation of immune globulin therapy. Monitoring of urine output and renal function tests, including the measurement of blood urea nitrogen (BUN) and serum creatinine, is recommended prior to the initial infusion and at appropriate intervals thereafter. | 837,744 |
How should the interaction between Triamterene and Chlorpromazine be managed? Describe the necessary steps. | Close clinical monitoring for development of hypotension is recommended if phenothiazines or neuroleptic agents are used in patients receiving antihypertensive medications or vasodilators. A lower starting dosage and slower titration of the phenothiazine or neuroleptic may be appropriate, especially in the elderly. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. Patients should also avoid driving or operating hazardous machinery. | 145,264 |
What is the interaction between Dihydrocodeine and Paliperidone? | Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol) may result in profound sedation, respiratory depression, coma, and death. The risk of hypotension may also be increased with some CNS depressants (e.g., alcohol, benzodiazepines, phenothiazines). | 355,273 |
How should the interaction between Brodalumab and Vibrio cholerae CVD 103-HgR strain live antigen be managed? Describe the necessary steps. | In general, the US Department of Public Health Advisory Committee on Immunization Practices (ACIP) recommends that inactivated or killed vaccines be administered to non-HIV immunosuppressed patients according to the same guidelines as for healthy patients. For Haemophilus influenzae b vaccine, some experts recommend that it be administered at least 2 weeks before starting or 3 months after discontinuing chemotherapy when used in patients with Hodgkin's disease. For rabies vaccine, some authorities suggest that immunosuppressive agents should generally be avoided during postexposure therapy except when absolutely necessary for the treatment of other conditions. | 520,611 |
What is the severity level of interaction between Neratinib and Stiripentol? | Major | 39,223 |
How should the interaction between Alosetron and Osilodrostat be managed? Describe the necessary steps. | Because alosetron is associated with potentially serious and life-threatening, dose-related gastrointestinal adverse effects, concomitant use with CYP450 1A2 inhibitors should generally be avoided if possible (use with fluvoxamine is specifically contraindicated). If coadministration is required, it may be appropriate to initially prescribe a lower dosage of alosetron (e.g., 1 mg once a day). However, the product labeling does not offer recommendations for a dosage adjustment. Patients should be advised to immediately discontinue alosetron and notify their physician if they experience constipation or signs and symptoms of ischemic colitis such as rectal bleeding, bloody diarrhea, and new or worsening abdominal pain. Alosetron should not be resumed if ischemic colitis is diagnosed. Ischemic colitis and other serious complications such as obstruction, perforation, impaction, and toxic megacolon have resulted in hospitalization, blood transfusion, surgery, and death. | 807,239 |
How should the interaction between Acrivastine and Brexpiprazole be managed? Describe the necessary steps. | Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations. | 1,216,200 |
Explain the mechanism of interaction between Fingolimod and Docetaxel. | Synergy | 661,227 |
What is the severity level of interaction between Doxepin and Ethanol? | Moderate | 726,859 |
What is the severity level of interaction between Alimemazine and Bupropion? | Major | 1,013,138 |
What is the severity level of interaction between Eptifibatide and Ibritumomab tiuxetan? | Major | 330,686 |
What is the severity level of interaction between Vilanterol and Hydrochlorothiazide? | Moderate | 1,200,535 |
Explain the mechanism of interaction between Mecasermin and Glipizide. | Synergy | 579,526 |
Explain the mechanism of interaction between Cabozantinib and Vandetanib. | Synergy | 702,203 |
What is the severity level of interaction between Cinoxacin and Ferrous gluconate? | Moderate | 1,038,979 |
What is the interaction between Ziprasidone and Esketamine? | Concomitant use of esketamine with central nervous system (CNS) depressants may increase sedation and impairment of attention, judgment, thinking, reaction speed, and psychomotor skills. | 356,843 |
How should the interaction between Nadolol and Levamlodipine be managed? Describe the necessary steps. | Close clinical monitoring of patient hemodynamic response and tolerance is recommended if a calcium channel blocker is prescribed with a beta blocker, and the dosage of one or both agents adjusted as necessary. The same precaution should be observed when beta blocker ophthalmic solutions are used, since they are systemically absorbed and can produce clinically significant systemic effects even at low or undetectable plasma levels. | 65,500 |
What is the severity level of interaction between Brentuximab vedotin and Simvastatin? | Moderate | 1,224,585 |
Explain the mechanism of interaction between Saxagliptin and Erdafitinib. | Distribution | 469,646 |
Explain the mechanism of interaction between Rifabutin and Etonogestrel. | Metabolism | 573,498 |
What is the interaction between Bromocriptine and Paraldehyde? | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. | 1,117,783 |
What is the interaction between Nateglinide and Lonafarnib? | Coadministration with inhibitors of CYP450 2C9 may increase the plasma concentrations of lonafarnib. In vitro, lonafarnib has been shown to be primarily metabolized by CYP450 3A4 and, to a lesser extent, by CYP450 1A2, 2A6, 2C8, 2C9, 2C19, and 2E1. Increased exposure to lonafarnib may increase the risk and/or severity of adverse effects such as nausea, vomiting, diarrhea, anorexia, electrolyte disturbances, liver enzyme elevations, myelosuppression, infection, and hypertension. | 268,188 |
What is the interaction between Voxelotor and Apalutamide? | Coadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations and pharmacologic effects of voxelotor. The proposed mechanism is accelerated clearance of voxelotor due to induction of the CYP450 3A4 isoenzyme, which is the primary route of elimination of voxelotor. | 178,004 |
Explain the mechanism of interaction between Sulfisoxazole and Trabectedin. | Synergy | 1,358,706 |
How should the interaction between Mechlorethamine and Carboplatin be managed? Describe the necessary steps. | Close clinical and laboratory monitoring for hematologic and nonhematologic toxicities are recommended when antineoplastic agents are administered concurrently or during close intervals. Dosing adjustments may be necessary. The manufacturers' recommendations and institutional protocols for dosage, treatment regimens, monitoring, and management of toxicities should be consulted. | 480,187 |
Explain the mechanism of interaction between Clopidogrel and Eluxadoline. | Metabolism | 736,402 |
Explain the mechanism of interaction between Ticlopidine and Tasimelteon. | Metabolism | 523,359 |
What is the severity level of interaction between Ivacaftor and Asparaginase Escherichia coli? | Moderate | 745,394 |
How should the interaction between Perindopril and Meloxicam be managed? Describe the necessary steps. | Patients receiving ACE inhibitors who require prolonged (greater than 1 week) concomitant therapy with an NSAID should have blood pressure monitored more closely following initiation, discontinuation, or change of dosage of the NSAID. Renal function should also be evaluated periodically during prolonged coadministration. The interaction is not expected to occur with low doses (e.g., low-dose aspirin) or intermittent short-term administration of NSAIDs. | 410,452 |
What is the severity level of interaction between Romidepsin and Galantamine? | Moderate | 846,665 |
How should the interaction between Acetazolamide and Memantine be managed? Describe the necessary steps. | - | 1,113,358 |
What is the severity level of interaction between Tamoxifen and Butabarbital? | Moderate | 1,061,371 |
How should the interaction between Paliperidone and Dofetilide be managed? Describe the necessary steps. | Coadministration of dofetilide with other drugs that can prolong the QT interval has not been studied and is not recommended. | 313,477 |
How should the interaction between Halazepam and Apomorphine be managed? Describe the necessary steps. | The use of other sedating drugs should generally be avoided during apomorphine treatment. Patients prescribed these agents concurrently should be monitored for potentially excessive or prolonged CNS depression, especially if they are elderly or debilitated. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. | 792,552 |
How should the interaction between Chlordiazepoxide and Pindolol be managed? Describe the necessary steps. | Caution and close monitoring for development of hypotension is advised during coadministration of these agents. Avoid alcohol in patients receiving vasodilating antihypertensive drugs. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. | 961,570 |
What is the severity level of interaction between Oxymetholone and Idelalisib? | Moderate | 847,076 |
What is the severity level of interaction between Ticagrelor and Irinotecan? | Moderate | 40,460 |
What is the interaction between Oxaprozin and Triamterene? | Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and diuretics may adversely affect renal function due to NSAID inhibition of the renal synthesis of prostaglandins that help maintain renal perfusion in dehydrated states. The risk may be increased in patients on dietary sodium restriction. At the same time, hypotensive effect of the diuretics may be reduced because inhibition of prostaglandins can lead to unopposed pressor activity and, consequently, elevation in blood pressure. Natriuretic and diuretic effects may also be reduced, as NSAIDs have been reported to cause sodium and water retention, which may account for the increased risk of congestive heart failure associated with the combination. NSAIDs may also increase the risk of hyperkalemia associated with potassium-sparing diuretics. | 485,432 |
What is the severity level of interaction between Lefamulin and Triclabendazole? | Major | 147,828 |
Explain the mechanism of interaction between Doxepin and Celecoxib. | Metabolism | 1,245,784 |
What is the severity level of interaction between Durvalumab and Lenalidomide? | Major | 1,089,081 |
What is the severity level of interaction between Ozanimod and Ephedrine? | Moderate | 1,195,247 |
Explain the mechanism of interaction between Metoprolol and Epoprostenol. | Synergy | 917,067 |
Explain the mechanism of interaction between Exenatide and Tesamorelin. | Antagonism | 630,907 |
How should the interaction between Pexidartinib and Gilteritinib be managed? Describe the necessary steps. | The use of pexidartinib with other potentially hepatotoxic agents should be avoided. Patients treated with pexidartinib should have liver function tests, including AST, ALT, total bilirubin, direct bilirubin, ALP, and gamma-glutamyl transferase (GGT), prior to initiation of pexidartinib, weekly for the first 8 weeks, every 2 weeks for the next month, and every 3 months thereafter. Pexidartinib therapy may require a dosage reduction, to be withheld, or permanently discontinued based on the severity of the hepatotoxicity. A recurrence of increased serum transaminases, bilirubin, or ALP may occur upon rechallenge with a reduced dose of pexidartinib. Liver function tests should be performed weekly for the first month after rechallenge. Patients should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, malaise, right upper quadrant pain, dark urine, pale stools, and jaundice. | 477,017 |
Explain the mechanism of interaction between Disopyramide and Propantheline. | Synergy | 46,572 |
What is the severity level of interaction between Praziquantel and Pexidartinib? | Moderate | 136,446 |
What is the severity level of interaction between Suvorexant and Dexbrompheniramine? | Moderate | 684,704 |
How should the interaction between Ixazomib and Secnidazole be managed? Describe the necessary steps. | Patients should be monitored closely for symptoms of neuropathy such as burning, tingling, pain, or numbness in the hands and feet. Since the development of peripheral neuropathy may be dose-related for many drugs, the recommended dosages should generally not be exceeded. Consideration should be given to dosage reduction or immediate discontinuation of these medications in patients who develop peripheral neuropathy to limit further damage. | 320,504 |
What is the severity level of interaction between Mephentermine and Methylene blue? | Major | 75,042 |
Explain the mechanism of interaction between Dichloralphenazone and Zonisamide. | Synergy | 504,290 |
How should the interaction between Artesunate and Pazopanib be managed? Describe the necessary steps. | Monitoring for adverse reactions is recommended if artesunate is coadministered with potent UGT inhibitors. Dosage adjustments or alternative treatments may be required based on clinical response and tolerance. | 1,139,574 |
What is the interaction between Bupropion and Doxazosin? | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
abdominal pain adrenal insufficiency Amnesia anaemia Anorexia Anxiety aortic regurgitation Aching joints Arthritis rheumatoid asthenia More | 906,507 |
Explain the mechanism of interaction between Fenofibrate and Clopidogrel. | Metabolism | 1,267,127 |
Explain the mechanism of interaction between Pfizer-BioNTech Covid-19 Vaccine and Fluorouracil. | Antagonism | 1,326,993 |
How should the interaction between Halofantrine and Echinacea be managed? Describe the necessary steps. | In general, patients should be advised to consult their healthcare provider before using any herbal or alternative medicines. If echinacea is prescribed with a drug that is a CYP450 3A4 substrate, the possibility of an altered (increased or decreased) therapeutic response should be considered. Patients should be monitored more closely following the addition or withdrawal of echinacea and the dosage of the CYP450 3A4 substrate adjusted as necessary. | 770,157 |
What is the severity level of interaction between Telmisartan and Dezocine? | Moderate | 1,374,786 |
How should the interaction between Fosphenytoin and Tramadol be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 1,230,654 |
How should the interaction between Sodium sulfate and Choline salicylate be managed? Describe the necessary steps. | Caution is advised when bowel cleansing preparations are used in patients treated with agents that affect renal function or perfusion, particularly if they are frail or elderly or have preexisting renal impairment. Baseline and postprocedure labs including serum electrolytes, BUN, and creatinine should be considered. Patients should be advised to drink sufficient quantities of clear fluids before, during, and after bowel cleansing. Hospitalization and intravenous fluid hydration may be appropriate for frail or elderly patients who may be unable to drink an adequate volume of fluid. | 859,550 |
Explain the mechanism of interaction between Clarithromycin and Bosentan. | Metabolism | 945,331 |
Explain the mechanism of interaction between Isocarboxazid and Paramethadione. | Synergy | 484,259 |
What is the interaction between Escitalopram and Deutetrabenazine? | Escitalopram can cause dose-dependent prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. | 1,339,948 |
What is the severity level of interaction between Doxazosin and Alfuzosin? | Moderate | 545,392 |
What is the interaction between Lidocaine and Cobicistat? | Coadministration with cobicistat may increase the plasma concentrations of lidocaine. The proposed mechanism involves cobicistat inhibition of CYP450 3A4-mediated metabolism of lidocaine. The interaction has not been specifically studied, but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities if levels are significantly increased. | 93,051 |
How should the interaction between Lefamulin and Dalfopristin be managed? Describe the necessary steps. | Caution is advised when lefamulin is used with CYP450 3A4 and/or P-gp inhibitors. Patients should be monitored for increased adverse effects and seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. | 330,467 |
Explain the mechanism of interaction between Letrozole and Stiripentol. | Metabolism | 922,088 |
What is the interaction between Bexarotene and Olaparib? | Coadministration with other myelosuppressive agents may potentiate and prolong the bone marrow toxicity associated with olaparib. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) have been reported in patients treated with olaparib. | 903,324 |
How should the interaction between Telaprevir and Fentanyl be managed? Describe the necessary steps. | Patients receiving fentanyl with potent or moderate CYP450 3A4 inhibitors should be carefully monitored, and dosage adjustments made accordingly as needed. This is particularly important when an inhibitor is added after a stable dose of fentanyl has been achieved. Patients and/or their caregivers should be advised to seek medical attention if potential signs and symptoms of toxicity occur, such as dizziness, confusion, fainting, extreme sedation, unresponsiveness, bradycardia, slow or difficult breathing, and shortness of breath. | 110,294 |
What is the severity level of interaction between Progesterone and Chlorpropamide? | Moderate | 1,287,864 |
What is the interaction between Iloperidone and Dexbrompheniramine? | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. | 112,989 |
What is the interaction between Chlorcyclizine and Ifosfamide? | Centrally-acting agents such as antiemetics, sedatives, narcotics, or antihistamines may add to the neurotoxic effects of ifosfamide. Administration of ifosfamide can cause CNS toxicity, which necessitates careful monitoring of the patient. Neurologic manifestations include somnolence, confusion, hallucinations, blurred vision, psychotic behavior, extrapyramidal symptoms, urinary incontinence, seizures, and in some instances, coma. There have also been reports of peripheral neuropathy. Ifosfamide neurotoxicity may occur within a few hours to a few days after initial administration and typically resolves within 48 to 72 hours of ifosfamide discontinuation. | 457,421 |
Explain the mechanism of interaction between Nitrous acid and Lidocaine (topical). | Synergy | 80,214 |
What is the interaction between Amphotericin B (lipid complex) and Amikacin? | The potential nephrotoxicity associated with amphotericin B and aminoglycosides may be additive.
abdominal distension abdominal pain abscess Acidosis renal tubular acidosis alopecia anaphylactic reaction anaemia Anxiety aphasia More | 50,131 |
What is the interaction between Oliceridine and Azelastine (nasal)? | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. | 1,140,807 |
How should the interaction between Darunavir and Mestranol be managed? Describe the necessary steps. | Caution is advised if darunavir must be used concurrently with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever darunavir is added to or withdrawn from therapy. | 568,167 |
What is the severity level of interaction between Estradiol (topical) and Nateglinide? | Moderate | 454,030 |
What is the interaction between Pimecrolimus (topical) and Pexidartinib? | Coadministration with pexidartinib may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 3A4. The proposed mechanism is increased clearance due to pexidartinib-mediated induction of CYP450 3A4 isoenzyme. | 634,830 |
What is the interaction between Ramipril and Salsalate? | Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effects of ACE inhibitors. The proposed mechanism is NSAID-induced inhibition of renal prostaglandin synthesis, which results in unopposed pressor activity producing hypertension. In addition, NSAIDs can cause fluid retention, which also affects blood pressure. Concomitant use of NSAIDs and ACE inhibitors may also cause deterioration in renal function, particularly in patients who are elderly or volume-depleted (including those on diuretic therapy) or have compromised renal function. Acute renal failure may occur, although effects are usually reversible. Chronic use of NSAIDs alone may be associated with renal toxicities, including elevations in serum creatinine and BUN, tubular necrosis, glomerulitis, renal papillary necrosis, acute interstitial nephritis, nephrotic syndrome, and renal failure. | 8,627 |