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733500150
73350-01-50
FANCC gene; variants
Fanconi anemia, complementation group C (FANCC) common gene variants analysis (e.g. IVS4+4A>T)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Fanconi anemia, type C).
null
null
null
733500160
73350-01-60
FLT3 gene; ITD
Fms-related tyrosine kinase 3 (FTL3) gene analysis of internal tandem duplication variants (TTD) (e.g. exons 14, 15)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. acute myeloid leukemia).
null
null
null
733500810
73350-08-10
MSH6 gene; Familial variant
MutS homolog 6 [E. coli] (MSH6) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation) (e.g. Lynch syndrome)
null
null
null
733500811
73350-08-11
MSH6 gene; Dup/Del
MutS homolog 6 [E. coli] (MSH6) duplication and deletion analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for analysis of repeated or deleted nucleotides (e.g. negative tested patients of suspected MSH6 mutations)
null
null
null
733500200
73350-02-00
G6PC gene; variants
Glucose-6-phosphatase, catalytic subunit (G6PC) common gene variants analysis (e.g. R83C, Q347X)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Glycogen storage disease, type 1a, von Gierke disease)
null
null
null
733500210
73350-02-10
HFE gene; variants
Hemochromatosis (HFE) common gene variants analysis (e.g. C282Y, H63D)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. hereditary hemochromatosis)
null
null
null
733500230
73350-02-30
MTHFR gene; variants
Methylenetetrahydrofolate reductase (MTHFR) common gene variants analysis (e.g. 677T, 1298C)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Homocystinuria due to MTHFR deficiency)
null
null
null
733500231
73350-02-31
MYD88 gene; variants
Myeloid differentiation primary response 88 gene (MYD88) specific gene variant analysis (L265P)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Waldenstrom macroglobulinemia)
null
null
null
733500232
73350-02-32
NPM1 gene; variants
Nucleophosmin (NPM1) specific gene variant analysis (exon 12 mutations)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. acute myeloid leukemia)
Nucleophosmin (NPM1) specifc gene variant analysis (eon 12 mutations)
null
null
733500233
73350-02-33
NRAS gene; variants
Neuroblastoma RAS viral, v–ras, oncogene homolog (NRAS) specific gene variant analysis (exon 12; e.g. codons 12, 13) (exon 13; e.g. codon 61)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Waldenstrom macroglobulinemia)
null
null
null
733500234
73350-02-34
NTRK1 gene; variants
Neurotrophic receptor tyrosine kinase 1 (NTRK1) variant translocation analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection using formalin–fixed paraffin embedded tissue (FFPE) specimen by PCR or NGS (e.g. solid tumors)
null
null
Do not assign this code if the test was performed by methods other than PCR or NGS (e.g. FISH or IHC) instead use specific procedure code as (73200-09-60, 73200-08-30)
733500235
73350-02-35
NTRK2 gene; variants
Neurotrophic receptor tyrosine kinase 2 (NTRK2) variant translocation analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection using formalin–fixed paraffin embedded tissue (FFPE) specimen by PCR or NGS (e.g. solid tumors)
null
null
Do not assign this code if the test was performed by methods other than PCR or NGS (e.g. FISH or IHC) instead use specific procedure code as (73200-09-60, 73200-08-30)
733500170
73350-01-70
G6PD gene; variants
Gglucose-6-phosphate dehydrogenase (G6PD) common gene variants analysis (e.g. A, A-)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. hemolytic anemia, jaundice)
null
null
null
733500180
73350-01-80
G6PD gene; Familial variants
Gglucose-6-phosphate dehydrogenase (G6PD) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation) (e.g. hemolytic anemia, jaundice)
null
null
null
733500190
73350-01-90
G6PD gene; Full Sequence
Gglucose-6-phosphate dehydrogenase (G6PD) full sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. hemolytic anemia, jaundice)
null
null
null
733500236
73350-02-36
NTRK3 gene; variants
Neurotrophic receptor tyrosine kinase 3 (NTRK3) variant translocation analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection using formalin–fixed paraffin embedded tissue (FFPE) specimen by PCR or NGS (e.g. solid tumors)
null
null
Do not assign this code if the test was performed by methods other than PCR or NGS (e.g. FISH or IHC) instead use ()
733500237
73350-02-37
NTRK1/2/3 gene; variants
Neurotrophic receptor tyrosine kinase 1/2/3 (NTRK1/2/3) variant translocation analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection using formalin–fixed paraffin embedded tissue (FFPE) specimen by PCR or NGS (e.g. solid tumors)
null
null
null
733500238
73350-02-38
NUDT15 gene; variants
Nudix hydrolase 15 gene (NUDT15) common gene variants analysis (e.g. *2, *3, *4, *5, *6)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. before treatment with thiopurines)
null
null
null
733500239
73350-02-39
PABPN1 gene; Evaluation
Poly[A] binding protein nuclear 1 gene (PABPN1) expanded sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for abnormal expanded alleles (e.g. oculopharyngeal muscular dystrophy (OPMD))
null
null
null
733500258
73350-02-58
PALB2 gene; Full Sequence
Partner and localizer of BRCA2 (PALB2) full gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. Fanconi anemia, of breast or pancreatic cancer)
Gene panel test and PALB2 gene
null
Do not assign this code If a gene panel test is performed and includes the PALB2 gene (e.g. hereditary breast cancer panel)
733500259
73350-02-59
PALB2 gene; Familial variant
Partner and localizer of BRCA2 (PALB2) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation) (e.g. Fanconi anemia, of breast or pancreatic cancer)
Gene panel test and PALB2 gene
null
Do not assign this code If a gene panel test is performed and includes the PALB2 gene (e.g. hereditary breast cancer panel)
733500251
73350-02-51
PIK3CA gene; Target sequence
Phosphatidylinositol–4, 5–biphosphate 3–kinase, catalytic subunit alpha (PIK3CA) specific sequence analysis on exons 7, 9, and 2
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection on specific site (e.g. breast cancer or colorectal cancer)
null
null
null
733500252
73350-02-52
PLCG2 gene; variants
Phospholipase C gamma 2 (PLCG2) common gene variants analysis (e.g. R665W, S707F, L845F)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. lymphocytic leukemia (CLL))
null
null
This test is usually ordered in conjunction to (BTK Gene; Variants)
733500253
73350-02-53
PML/RARalpha Fusion genes; Common breakpoint; Quant./Qual.
Quantitative/Qualitative translocation analysis (t(15;17)) of common breakpoint regions (e.g. introns 3 AND 6) on the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion gene
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for breakpoints due to translocation, forming altered gene sequence (e.g. acute promyelocytic leukemia)
null
null
null
733500254
73350-02-54
PML/RARalpha Fusion genes; Single breakpoint; Quant./Qual.
Quantitative/Qualitative translocation analysis (t(15;17)) of common breakpoint regions (e.g. introns 3 OR 6) on the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion gene
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for breakpoints due to translocation, forming altered gene sequence (e.g. acute promyelocytic leukemia)
null
null
null
733500255
73350-02-55
PMP22 gene; Dup/Del
Peripheral myelin protein 22 (PMP22) duplication and deletion analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for analysis of repeated or deleted nucleotides (e.g. Charcot–Marie–tooth)
null
null
null
733500256
73350-02-56
PMP22 gene; Full sequence
Peripheral myelin protein 22 (PMP22) full gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. Charcot–Marie–tooth)
null
null
null
733500257
73350-02-57
PMP22 gene; Familial variant
Peripheral myelin protein 22 (PMP22) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation)(e.g. Charcot–Marie–tooth)
null
null
null
733500261
73350-02-61
PMS2 gene; Full Sequence
Postmeiotic segregation increased 2 [S. cerevisiae] (PMS2) full gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. Lynch syndrome)
null
null
null
733500262
73350-02-62
PMS2 gene; Familial variant
Postmeiotic segregation increased 2 [S. cerevisiae] (PMS2) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation)(e.g. Lynch syndrome)
null
null
null
733500263
73350-02-63
PMS2 gene; Dup/Del
Postmeiotic segregation increased 2 [S. cerevisiae] (PMS2) duplication and deletion analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for analysis of repeated or deleted nucleotides (e.g. Lynch syndrome)
null
null
null
733500264
73350-02-64
PPP2R2B gene; Evaluation
Phosphatase 2 regulatory subunit B beta (PPP2R2B) expanded sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for abnormal expanded alleles (e.g. spinocerebellar ataxia 12 (SCA12))
null
null
null
733500265
73350-02-65
PTEN gene; Full sequence
Phosphatase and tensin homolog (PTEN) full gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. hamartoma tumor syndrome, Cowden syndrome)
null
null
null
733500266
73350-02-66
PTEN gene; Familial variant
Phosphatase and tensin homolog (PTEN) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation) (e.g. hamartoma tumor syndrome, Cowden syndrome)
null
null
null
733500267
73350-02-67
PTEN gene; Dup/Del
Phosphatase and tensin homolog (PTEN) duplication and deletion analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for analysis of repeated or deleted nucleotides (e.g. hamartoma tumor syndrome, Cowden syndrome)
null
null
null
733500268
73350-02-68
RUNX1 gene; Target sequence
Runt related transcription factor 1 (RUNX) specific sequence analysis on exons 3–8
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection on specific site (e.g. acute myeloid leukemia (AML))
null
null
null
733500269
73350-02-69
SEPT9 gene; Methylation
Septin9 (SEPT9) promoter methylation analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Test to assess genetic changes related to the disease (e.g. colorectal cancer)
null
null
null
733500271
73350-02-71
SERPINA1 gene; variants
Serpin peptidase inhibitor, clade A, alpha–1 antiproteinase, antitrypsin, member 1 (SERPINA1) common gene variants analysis (e.g. *S and *Z)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Alpha–1–antitrypsin deficiency)
null
null
null
733500272
73350-02-72
SF3B1 gene; variants
Splicing factor [3b] subunit B1 (SF3B1) common gene variants analysis (e.g. A672T, E622D, L833F, R625C, R625L)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. myelodysplastic syndrome (MDS)
null
null
null
733500273
73350-02-73
SLCO1B1 gene; variants
Solute carrier organic anion transporter family, member 1B1 (SLCO1B1) common gene variants analysis (e.g. *5)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. myopathy, assessment of statin therapy risk)
null
null
null
733500274
73350-02-74
SMN1/SMN2 gene; Deletions
Survival of telomeric motor neuron 1 (SMN1) and survival of centromeric motor neuron 2 (SMN2) deletion analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for analysis of deleted nucleotides (e.g. spinal muscular atrophy (SMA))
null
null
null
733500275
73350-02-75
SMN1 gene; Full sequence
Survival of telomeric motor neuron 1 (SMN1) full gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. spinal muscular atrophy (SMA))
null
null
null
733500276
73350-02-76
SMN1 gene; Familial variant
Survival of telomeric motor neuron 1 (SMN1) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation) (e.g. spinal muscular atrophy (SMA))
null
null
null
733500220
73350-02-20
JAK2 gene; variants
Janus Kinase 2 (JAK2) specific gene variant analysis (V617F)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Erythrocytosis, Leukemia, Thrombocythemia 3)
null
null
null
733500277
73350-02-77
SMPD1 gene; variants
Sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) common gene variants analysis (e.g. R496L, L302P, fsP330)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. Niemann–Pick disease)
null
null
null
733500278
73350-02-78
SNRPN/UBE3A; Methylation
Small nuclear ribonucleoprotein polypeptide N (SNRPN) and ubiquitin–protein ligase E3A (UBE3A) methylation analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Test to assess genetic changes related to the disease (e.g. Prader–Willi syndrome (PWS) or Angelman syndrome (AS))
null
null
Do not assign this code if only one of the two genes are tested or if a method other than methylation analysis is utilized.
733500279
73350-02-79
SRSF2 gene; variants
Serine and arginine–rich splicing factor 2 (SRSF2) common gene variants analysis (e.g. P95H, P95L)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. myeloid disorders)
null
null
null
733500281
73350-02-81
TBP gene; Evaluation
TATA box binding protein (TBP) expanded sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for abnormal expanded alleles (e.g. spinocerebellar ataxia 17 (SCA17))
null
null
null
733500282
73350-02-82
TERT gene; Target sequence
Telomerase reverse transcriptase gene (TERT) specific sequence analysis on promotor region
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection on specific site (e.g. central nervous system tumors)
null
null
null
733500283
73350-02-83
TGFBI gene; variants
Transforming growth factor beta–induced gene (TGFBI) common gene variants analysis (e.g. R124H, R124C, R124L, R555W, R555Q)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. corneal dystrophy)
null
null
null
733500284
73350-02-84
TP53 gene; Full sequence
Tumor protein 53 (TP53) full gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Full sequence of a gene (e.g. Li–Fraumeni syndrome)
null
TP53 gene testing
Do not assign this code if a panel that includes testing the TP53 gene was performed (e.g. Hereditary breast or colon cancer panels)
733500285
73350-02-85
TP53 gene; Target Sequence
Tumor protein 53 (TP53) specific sequence analysis (e.g. 4 oncology)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection on specific site (e.g. Li–Fraumeni syndrome)
null
TP53 gene testing
Do not assign this code if a panel that includes testing the TP53 gene was performed (e.g. Hereditary breast or colon cancer panels)
733500286
73350-02-86
TP53 gene; Familial variant
Tumor protein 53 (TP53) analysis of known familial variant
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of specific, familial, gene sequence alteration (variant/mutation) (e.g. Li–Fraumeni syndrome)
null
TP53 gene testing
Do not assign this code if a panel that includes testing the TP53 gene was performed (e.g. Hereditary breast or colon cancer panels)
733500287
73350-02-87
TPMT gene; variants
Thiopurine S–methyltransferase (TPMT) common gene variants analysis (e.g. *2, *3)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. transplant recipient, acute lymphoblastic leukemia)
null
null
null
733500291
73350-02-91
TRB@ gene variants; PCR
T–cell populations from T–cell antigen receptor, beta (TCRB; TRB@) gene rearrangements analysis by polymerase chain reaction
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. leukemias, lymphomas)
null
null
null
733500292
73350-02-92
TRB@ gene variants; Southern blot
T–cell populations from T–cell antigen receptor, beta (TCRB; TRB@) gene rearrangements analysis by Southern blot
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. leukemias, lymphomas)
null
null
null
733500293
73350-02-93
TRB@ gene variants
T–cell populations from T–cell antigen receptor, beta (TCRB; TRB@) gene rearrangements analysis (abnormal clonal populations)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. leukemias, lymphomas)
null
null
null
733500294
73350-02-94
TYMS gene; variants
Thymidylate synthetase (TYMS) common gene variants analysis (e.g. tandem repeats)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. solid tumors)
null
null
null
733500295
73350-02-95
U2AF1 gene; variants
U2 small nuclear RNA auxiliary factor 1 (U2AF1) common gene variants analysis (e.g. S34F, S34Y, Q157R, Q157P)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. hematologic disorders)
null
null
null
733500296
73350-02-96
UGT1A1 gene; variants
UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) common gene variants analysis (e.g. *28, *36, *37)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. cancer drug administration, Gilbert syndrome)
null
null
null
733500288
73350-02-88
VKORC1 gene; variants
Vitamin K epoxide reductase complex, subunit 1(VKORC1) common gene variants analysis (e.g. -1639G>A, c.173+1000C>T)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. blood thinner administration, mechanical heart valve replacement)
null
null
null
733500289
73350-02-89
ZRSR2 gene; variants
Zinc finger CCCH–type, RNA binding motif and serine/arginine–rich 2 (ZRSR2) common gene variants analysis (e.g. E65fs, E122fs, R448fs)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection (e.g. hematologic disorders)
null
null
null
733500521
73350-05-21
Aortic Dysfunction/Dilation Panel
Aortic Dysfunction/Dilation; genomic sequencing analysis panel of minimum 9 genes, containing (FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes involving methods as Next Generation Sequencing (Marfan syndrome, Loeys Dietz syndrome, Ehler Danlos syndrome type IV, and arterial tortuosity syndrome)
null
null
null
733500522
73350-05-22
Aortic Dysfunction/Dilation; Dup/Del Panel
Aortic Dysfunction/Dilation; duplication and deletion analysis panel of minimum 9 genes, containing (FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Duplication/deletion analysis of multiple genes involving methods as Next Generation Sequencing (Marfan syndrome, Loeys Dietz syndrome, Ehler Danlos syndrome type IV, and arterial tortuosity syndrome)
null
null
null
733500523
73350-05-23
Ashkenazi Jewish Disorders Panel
Ashkenazi Jewish associated disorders (e.g. Bloom syndrome, cystic fibrosis, Fanconi C anemia, Tay-Sachs disease); genomic sequence analysis panel of minimum 9 genes, containing (ASPA, BLM, CFTR, FANCC, GBA, HEXA, IKBKAP, MCOLN1, and SMPD1)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes involving methods as Next Generation Sequencing (Bloom syndrome, Canavan disease, cystic fibrosis, familial dysautonomia, Fanconi anemia group C, Gaucher disease, Tay-Sachs disease)
Gene sequencing
null
Do not assign code for gene sequencing or any other testing method for genes included in this panel
733500524
73350-05-24
Cardiac ion channelopathies panel
Cardiac ion channelopathies (e.g. Brugada syndrome, long/short QT syndrome, catecholaminergic polymorphic ventricular tachycardia); genomic sequence analysis panel of minimum 10 genes, containing (ANK2, CASQ2, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, RYR2, and SCN5A)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes involving methods as Next Generation Sequencing
Gene sequencing
null
Do not assign code for gene sequencing or any other testing method for genes included in this panel
733500525
73350-05-25
Cardiac Ion Channelopathies; Dup/Del Panel
Cardiac ion channelopathies (e.g. Brugada syndrome, long/short QT syndrome, catecholaminergic polymorphic ventricular tachycardia); duplication and deletion analysis panel of minimum 2 genes, containing (KCNH2 and KCNQ1)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Duplication/deletion analysis of multiple genes involving methods as Next Generation Sequencing
null
null
null
733500526
73350-05-26
Epilepsy panel
Epilepsy; genomic sequence analysis panel of minimum 24 genes, containing (ALDH7A1, CACNA1A, CDKL5, CHD2, GABRG2, GRIN2A, KCNQ2, MECP2, PCDH19, POLG, PRRT2, SCN1A, SCN1B, SCN2A, SCN8A, SLC2A1, SLC9A6, STXBP1, SYNGAP1, TCF4, TPP1, TSC1, TSC2, and ZEB2)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes involving methods as Next Generation Sequencing
null
null
Do not separately assign individual gene codes in addition to this panel.
733500527
73350-05-27
Exome analysis
Exome (e.g unexplained disorder); gene sequence analysis
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Exome analysis for detection of variants potentially causing unexplained disorder
null
null
Do not assign this code with (WGS by NGS). It is possible to report all or any of the following codes together based on the performed testing (Exome Analysis, Exome Analysis; Comparator Reference, Exome Re-Evaluation)
733500528
73350-05-28
Exome Analysis; Comparator Reference
Exome (e.g unexplained disorder); creation of reference exome gene sequence
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Reference exome creation (from parent, sibling, relative) for comparison to patient in order to evaluate unexplained disorders
null
null
Do not assign this code with (WGS by NGS). This is an additional code to be assigned with (Exome Analysis). Do not report this code alone. It is possible to report all or any of the following codes together based on the performed testing (Exome Analysis, Exome Analysis, Comparator Reference, Exome Re-Evaluation)
733500529
73350-05-29
Exome re-evaluation
Re-evaluation of existing exome gene sequence (previously obtained)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Reevaluation of patient exome due to emergence of new information
null
null
Do not assign this code for incidental findings. It is possible to report all or any of the following codes together based on the performed testing (Exome Analysis, Exome Analysis, Comparator Reference, Exome Re-Evaluation)
733500545
73350-05-45
Severe inherited conditions panel
Severe inherited conditions (e.g. cystic fibrosis, Ashkenazi Jewish-associated disorders like [Bloom syndrome, Canavan disease, Fanconi anemia type C, mucolipidosis type VI, Gaucher disease, Tay-Sachs disease], phenylketonuria, beta hemoglobinopathies, galactosemia; gene sequence analysis panel of minimum 15 genes, including (ACADM, ARSA, ASPA, ATP7B). BCKDHA, BCKDHB, BLM, CFTR, DHCR7, FANCC, G6PC, GAA, GALT, GBA, GBE1, HBB, HEXA, IKBKAP, MCOLN1, PAH
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
Ashkenazi Jewish Disorders Panel
null
Do not assign this code with (Ashkenazi Jewish Disorders Panel). Do not separately report the genes included in this panel.
733500546
73350-05-46
X-linked intellectual disability panel
X-linked Intellectual Disability (e.g. syndromic and non-syndromic XLID) genome sequence analysis panel of minimum 60 genes, including (ARX, ATRX, CDKL5, FGD1, FMR1, HUWE1, IL1RAPL, KDM5C, L1CAM, MECP2, MED12, MID1, OCRL, RPS6KA3, and SLC16A2).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
null
733500547
73350-05-47
X-linked intellectual disability; Dup/Del Panel
X-linked Intellectual Disability (e.g. syndromic and non-syndromic XLID) duplication/deletion analysis panel of minimum 60 genes, including (ARX, ATRX, CDKL5, FGD1, FMR1, HUWE1, IL1RAPL, KDM5C, L1CAM, MECP2, MED12, MID1, OCRL, RPS6KA3, and SLC16A2).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Duplication/deletion analysis of multiple genes for multiple disorders involving methods as Multiplex Ligation dependent Probe Amplification (MLPA)
null
null
null
733500571
73350-05-71
Hearing loss panel
Hereditary retinal disorders (e.g. Usher syndrome, nonsyndromic hearing loss, Pendred syndrome); genome sequence analysis panel of at least 60 genes including (CDH23, CLRN1, GJB2, GPR98, MTRNR1, MYO7A, MYO15A, PCDH15, OTOF, SLC26A4, TMC1, TMPRSS3, USH1C, USH1G, USH2A, and WFS1).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
Analysis of at least 60 genes, panel must include listed genes
733500572
73350-05-72
Hearing loss; Dup/Del Panel
Hearing loss disorders (e.g. Usher syndrome, nonsyndromic hearing loss, Pendred syndrome);duplication and deletion analysis panel, including (STRC and DFNB1 copy number analysis; and GJB2 and GJB6 gene deletions).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Duplication/deletion analysis of multiple genes for multiple disorders involving methods as Multiplex Ligation dependent Probe Amplification (MLPA)
null
null
null
733500573
73350-05-73
Hereditary retinal disorders panel
Hereditary Retinal Disorders (e.g. Leber congenital amaurosis, cone-rod dystrophy. retinitis pigmentosa) genome sequence analysis panel of minimum 15 genes, including (ABCA4, CNGA1, CRB1, EYS, PDE6A, PDE6B, PRPF31, PRPH2, RDH12, RHO, RP1, RP2, RPE65, RPGR, and USH2A)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
Do not separately code each of the genes listed in this panel.
733500591
73350-05-91
Hereditary colon cancer panel
Hereditary Colon Cancer (e.g. Cowden syndrome, Lynch syndrome, PTEN hamartoma syndrome, familial adenomatosis polyposis) genome sequence analysis panelof minimum 10 genes, including (APC, BMPR1A, CDH1, MLH1, MSH2, MSH6, MUTYH, PTEN, SMAD4, and STK11).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
Do not separately code each of the genes listed in this panel.
733500240
73350-02-40
PCA3/KLK3 gene; Ratio
Nonprotein coding prostate cancer antigen 3 (PCA3) and prostate specific antigen kallikrein related peptidase (KLK3) evaluation of gene ratio
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Evaluation of gene ratio (e.g. prostate cancer monitoring)
null
null
null
733500250
73350-02-50
PDGFRA gene; Target sequence
Platelet–derived growth factor receptor, alpha polypeptide (PDGFRA) specific sequence analysis on exon 12 and 18
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Testing for mutation detection on specific site (e.g. gastrointestinal stromal tumor)
null
null
null
733500592
73350-05-92
Hereditary colon cancer dup/del panel
Hereditary Colon Cancer (e.g. Cowden syndrome, Lynch syndrome, PTEN hamartoma syndrome, familial adenomatosis polyposis) duplication/deletion analysis panel of minimum 5 genes, including (MLH1, MSH2, EPCAM, SMAD4, and STK11).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Duplication/deletion analysis of multiple genes for multiple disorders involving methods as Multiplex Ligation dependent Probe Amplification (MLPA)
null
null
Do not separately code each of the genes listed in this panel.
733500593
73350-05-93
Hereditary neuroendocrine tumors panel
Hereditary Neuroendocrine Tumor disorders (e.g. parathyroid carcinoma, medullary thyroid carcinoma, malignant pheochromocytoma or paraganglioma) genome sequence analysis panel of minimum 6 genes, including (MAX, SDHB, SDHC, SDHD, TMEM127, and VHL).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
Do not separately code each of the genes listed in this panel.
733500594
73350-05-94
Hereditary neuroendocrine tumors; dup/del panel
Hereditary Neuroendocrine Tumor disorders (e.g. parathyroid carcinoma, medullary thyroid carcinoma, malignant pheochromocytoma or paraganglioma) duplication/deletion analysis panel, including (SDHB, SDHC, SDHD, and VHL).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Duplication/deletion analysis of multiple genes for multiple disorders
null
null
Do not separately code each of the genes listed in this panel.
733500595
73350-05-95
Hereditary peripheral neuropathies panel
Hereditary Peripheral Neuropathies (e.g. Spastic paraplegia, Charcot-Marie-Tooth) genome sequence analysis panel of minimum 5 genes, including (BSCL2, GJB1, MFN2, MPZ, REEP1, SPAST, SPG11, SPTLC1).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
Do not separately code each of the genes listed in this panel.
733500596
73350-05-96
Hereditary cardiomyopathy panel
Hereditary Cardiomyopathy Panel (e.g. dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, hypertrophic cardiomyopathy) genome sequence analysis panel of minimum 5 genes, including (DSG2, MYBPC3, MYH7, PKP2, TTN).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
null
null
Do not assign this code with (Cardiac Ion Channelopathies Panel or Cardiac Ion Channelopathies; Dup/Del Panel) if they're performed on the same date of service. Do not separately code each of the genes listed in this panel.
733500597
73350-05-97
Mitochondrial nuclear panel
Mitochondrial genes encoded in the nucleus (e.g. neurologic or myopathic phenotypes) genome sequence analysis panel of minimum 100 genes, including (BCS1L, C10orf2, COQ2, COX10, DGUOK, MPV17, OPA1, PDSS2, POLG, POLG2, RRM2B, SCO1, SCO2, SLC25A4, SUCLA2, SUCLG1, TAZ, TK2, and TYMP).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
Mitochondrial genes encoded in the nucleus (e.g. neurologic or myopathic phenotypes) genome sequence analysis panel of minimum 100 genes, including (BCS1L, C10orf2, COQ2, Co10, DGUOK, MPV17, OPA1, PDSS2, POLG, POLG2, RRM2B, SCO1, SCO2, SLC25A4, SUCLA2, SUCLG1, TAZ, TK2, and TYMP).
null
null
733500598
73350-05-98
Noonan spectrum disorders panel
Noonan spectrum disorders (e.g. Noonan syndrome, Costello syndrome, LEOPARD syndrome, cardio-facio-cutaneous syndrome, Noonan-like syndrome) genome sequence analysis panel of minimum 12 genes, including (BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, SHOC2, and SOS1).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders involving methods as Next Generation Sequencing
Noonan spectrum Disorders (e.g. Noonan syndrome, Costello syndrome, LEOPARD syndrome, cardio-facio-cutaneous syndrome, Noonan-like syndrome) genome sequence analysis panel of minimum 12 genes, including (BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, SHOC2, and SOS1).
null
Do not separately code each of the genes listed in this panel.
733500581
73350-05-81
Hematolymphoid neoplasms panel; 5-50 genes
Hematolymphoid neoplasm; targeted genome sequence analysis panel (DNA or RNA) of 5-50 genes (e.g. BRAF, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KRAS, KIT, MLL, NRAS, NPM1, NOTCH1)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders (blood or lymph cancers) involving methods as Next Generation Sequencing
null
null
Do not separately code each of the genes listed in this panel.
733500582
73350-05-82
Hematolymphoid neoplasms panel; >50 genes
Hematolymphoid neoplasm; targeted genome sequence analysis panel (DNA or RNA) of 51 or more genes (e.g. ALK, BRAF, CDKN2A, CEBPA, DNMT3A, EGFR, ERBB2, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MLL, NPM1, NRAS, MET, NOTCH1, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET)
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Genomic sequencing analysis of multiple genes for multiple disorders (blood or lymph cancers) involving methods as Next Generation Sequencing
Hematolymphoid neoplasm; targeted genome sequence analysis panel (DNA or RNA) of 51 or more genes (e.g. ALK, BRAF, CDKN2A, CEBPA, DNMT3A, EGFR, ERBB2, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MLL, NPM1, NRAS, MET, NOTCH1, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET)
null
Do not separately code each of the genes listed in this panel.
733500583
73350-05-83
Mitochondrial genome
Whole mitochondrial genome (e.g. mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes [MELAS], Leigh syndrome, neuropathy, ataxia, and retinitis pigmentosa [NARP], myoclonic epilepsy with ragged-red fibers [MERFF], Leber hereditary optic neuropathy [LHON]); sequence analysis with heteroplasmy detection.
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of the entire mitochondrial genome (nerve or muscle pathologies)
Whole mitochondrial genome (e.g. mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes [MELAS], Leigh syndrome, neuropathy, ataia, and retinitis pigmentosa [NARP], myoclonic epilepsy with ragged-red fibers [MERFF], Leber hereditary optic neuropathy [LHon]); sequence analysis with heteroplasmy detection.
null
null
733500584
73350-05-84
Mitochondrial genome; large deletions
Whole mitochondrial genome (e.g. mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes [MELAS], Leigh syndrome, neuropathy, ataxia, and retinitis pigmentosa [NARP], myoclonic epilepsy with ragged-red fibers [MERFF], Leber hereditary optic neuropathy [LHON]); large deletions analysis with heteroplasmy detection (when conducted).
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Analysis of the entire mitochondrial genome for large deletions (nerve or muscle pathologies)
Whole mitochondrial genome (e.g. mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes [MELAS], Leigh syndrome, neuropathy, ataia, and retinitis pigmentosa [NARP], myoclonic epilepsy with ragged-red fibers [MERFF], Leber hereditary optic neuropathy [LHon]); large deletions analysis with heteroplasmy detection (when conducted).
null
null
733500611
73350-06-11
Heart transplant rejection risk
Measurement of potential heart transplant patient risk score by mRNA gene expression profiling of 20 genes utilizing quantitative polymerase chain reaction (QPCR) and peripheral blood subfraction
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for heart transplant
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500612
73350-06-12
CAD risk
Measurement of coronary artery disease (CAD) risk score by mRNA gene expression profiling of 23 genes utilizing real time polymerase chain reaction (RT-PCR) from whole peripheral blood
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for CAD
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500613
73350-06-13
T2DM risk
Measurement of type 2 diabetes (T2DM) risk score for 7 analytes by biochemical assays from serum or plasma
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for T2DM
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500640
73350-06-40
Tumor tissue origin profiling
Measurement of tumor tissue (unknown origin) similarity score to existing tumor database utilizing microarray gene expression profiling of > 2000 genes from formalin-fixed paraffin-embedded tissue
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for RNA expression patterns in a tumor of unknown origin and comparison to tumor database.
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500641
73350-06-41
Tumor tissue classification
Analysis of tumor tissue (unknown origin) for classification of main cancer type and subtype by gene expression profiling of 92 genes (87 content; 5 housekeeping) utilizing real time reverse transcription polymerase chain reaction (RT–PCR) from formalin-fixed paraffin-embedded tumor tissue.
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for tumor tissue classification
Analysis of tumor tissue (unknown origin) for classification of main cancer type and subtype by gene epression profiling of 92 genes (87 content; 5 housekeeping) utilizing real time reverse transcription polymerase chain reaction (RT–PCR) from formalin-fied paraffin-embedded tumor tissue.
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500642
73350-06-42
Uveal melanoma risk
Measurement of uveal melanoma metastatic risk score by mRNA gene expression profiling of 15genes (12 content; 3 housekeeping) utilizing real time reverse transcription polymerase chain reaction (RT–PCR) from fine needle aspirate or formalin-fixed paraffin-embedded tissue
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for uveal melanoma risk
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500643
73350-06-43
Usual interstitial pneumonia screen
Screening for Usual Interstitial Pneumonia (UIP) (positive/negative) by mRNA gene expression profiling of 190 genes from transbronchial biopsies
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for UPI risk
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500644
73350-06-44
Pediatric liver/small bowel allograft rejection risk
Measurement of pediatric Liver or Small Bowel allograft-transplant rejection risk-score for (CD154+T-cytotoxic memory cells) from whole peripheral blood
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for pediatric liver allograft rejection risk
null
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).
733500701
73350-07-01
Bacterial vaginosis screen
Detection of bacterial vaginosis RNA markers of (Atopobium vaginae, Gardnerella vaginalis, and Lactobacillus species) by quantitative real-time amplification from vaginal-fluid
21
Laboratory and Pathology
3,350
Molecular Pathology including Gene Sequencing
Multianalyte assay with algorithmic analysis (computer based) for BV
Detection of bacterial vaginosis & vaginitis DNA markers of (Gardnerella vaginalis, atopobium vaginae, Lactobacillus species (L. crispatus & L. jensenii), Megasphaera type 1, Bacterial Vaginosis Associated Bacteria-2 (BVAB-2)) with detection of Trichomonas vaginalis and Candida species by quantitative real-time amplification from vaginal-fluid
null
This code involve all the molecular tests required to produce the results. Do not separately code the technical lab tests. However, you may code any preparatory work conducted before cell lysis (e.g. microdissection or tissue selection from archived specimens).