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24425420 | results | For both group I and II , CFAE ablation prolonged AF cycle length ( @ versus @ ms ; P = @ ) and resulted in similar rates of AF termination ( @ % versus @ % ; P = @ ) . | 8 |
24425420 | results | Radiofrequency duration during CFAE ablation was significantly less in group II ( @ versus @ minutes ; P = @ ) . | 9 |
24425420 | results | At @-year follow-up , freedom from AF/atrial flutter/atrial tachycardia recurrence was significantly higher in group I versus group II after @ procedure ( @ % versus @ % ; P = @ ) . | 10 |
24425420 | results | There were also significantly fewer repeat procedures in group I ( @ % versus @ % ; P = @ ) . | 11 |
24425420 | conclusions | Continuous electric activity ablation + PVI result in a similar incidence of acute AF termination with significantly less radiofrequency time . | 12 |
24425420 | conclusions | However , incidence of repeat procedures and long-term recurrence of AF/atrial flutter/atrial tachycardia are significantly lower using generalized CFAE ablation + PVI . | 13 |
24425420 | conclusions | Clinical Trial Registration - URL : http://www.clinicaltrials.gov . | 14 |
24425420 | conclusions | Unique identifier : NCT@ . | 15 |
24262684 | objective | To determine if the use of a Bakri balloon at cesarean delivery ( CD ) for placenta previa is associated with a reduced need for additional surgical or pharmacologic measures and less blood loss than usual practices . | 0 |
24262684 | methods | In a randomized controlled trial , @ women undergoing CD for placenta previa were randomly allocated @:@ into an intervention arm ( prophylactic Bakri balloon immediately following placental delivery ) or a control arm ( use of any usual surgical/pharmacologic measures to achieve hemostasis ) . | 1 |
24262684 | methods | The primary outcomes were a clinician 's decision to undertake further intervention to control bleeding , and the difference between preoperative and postoperative hemoglobin levels . | 2 |
24262684 | results | Although fewer women in the intervention group required additional measures to achieve hemostasis during CD , the difference between the groups was not significant ( relative risk @ ; @ % confidence interval , @-@ @ ) . | 3 |
24262684 | results | The change in hemoglobin level among women in the intervention arm was also similar to that among controls ( @ g/dL ; @ % confidence interval , -@ to @ ) . | 4 |
24262684 | conclusions | The prophylactic use of a Bakri balloon at CD for placenta previa tended to be of benefit , with no evidence of harm or patient dissatisfaction , but the need for additional medical/surgical measures to control blood loss was not significantly reduced . | 5 |
24262684 | conclusions | Australian New Zealand Clinical Trials Registry : ACTRN@ . | 6 |
24439980 | background | Exercise training is recommended for chronic heart failure ( HF ) patients to improve functional status and reduce risk of adverse outcomes . | 0 |
24439980 | background | Elevated plasma levels of amino-terminal pro-brain natriuretic peptide ( NT-proBNP ) , high-sensitivity C-reactive protein ( hs-CRP ) , and cardiac troponin T ( cTnT ) are associated with increased risk of adverse outcomes in this patient population . | 1 |
24439980 | background | Whether exercise training leads to improvements in biomarkers and how such improvements relate to clinical outcomes are unclear . | 2 |
24439980 | results | Amino-terminal pro-brain natriuretic peptide , hs-CRP , and cTnT levels were assessed at baseline and @ months in a cohort of @ subjects from the HF-ACTION study , a randomized clinical trial of exercise training versus usual care in chronic HF patients with reduced left ventricular ejection fraction ( < @ % ) . | 3 |
24439980 | results | Linear and logistic regressions were used to assess @-month biomarker levels as a function of baseline value , treatment assignment ( exercise training vs usual care ) , and volume of exercise . | 4 |
24439980 | results | Linear regression and Cox proportional hazard modeling were used to evaluate the relations between changes in biomarker levels and clinical outcomes of interest that included change in peak oxygen consumption ( peak VO@ ) , hospitalizations , and mortality . | 5 |
24439980 | results | Exercise training was not associated with significant changes in levels of NT-proBNP ( P = @ ) , hs-CRP ( P = @ ) , or detectable cTnT levels ( P = @ ) at @ months . | 6 |
24439980 | results | Controlling for baseline biomarker levels or volume of exercise did not alter these findings . | 7 |
24439980 | results | Decreases in plasma concentrations of NT-proBNP , but not hs-CRP or cTnT , were associated with increases in peak VO@ ( P < @ ) at @ months and decreased risk of hospitalizations or mortality ( P @ ) , even after adjustment for a comprehensive set of known predictors . | 8 |
24439980 | conclusions | Exercise training did not lead to meaningful changes in biomarkers of myocardial stress , inflammation , or necrosis in patients with chronic HF . | 9 |
24439980 | conclusions | Only improvements in NT-proBNP translated to reductions in peak VO@ and reduced risk of clinical events . | 10 |
25411289 | background | Biofortification is a strategy to relieve vitamin A ( VA ) deficiency . | 0 |
25411289 | background | Biofortified maize contains enhanced provitamin A concentrations and has been bioefficacious in animal and small human studies . | 1 |
25411289 | objective | The study sought to determine changes in total body reserves ( TBRs ) of vitamin A with consumption of biofortified maize . | 2 |
25411289 | methods | A randomized , placebo-controlled biofortified maize efficacy trial was conducted in @ rural Zambian children . | 3 |
25411289 | methods | The paired ( @ ) C-retinol isotope dilution test , a sensitive biomarker for VA status , was used to measure TBRs before and after a @-d intervention . | 4 |
25411289 | methods | Treatments were white maize with placebo oil ( VA - ) , orange maize with placebo ( orange ) , and white maize with VA in oil -LSB- @ g retinol activity equivalents ( RAEs ) in @ L daily -RSB- ( VA + ) . | 5 |
25411289 | results | In total , @ children completed the trial and were analyzed for TBRs ( n = @ or @/group ) . | 6 |
25411289 | results | Change in TBR residuals were not normally distributed ( P < @ ) ; median changes ( @ % CI ) were as follows : VA - , @ ( -@ , @ ) mol ; orange , @ ( @ , @ ) mol ; and VA + , @ ( @ , @ ) mol . | 7 |
25411289 | results | Nonparametric analysis showed no statistical difference between VA + and orange ( P = @ ) ; both were higher than VA - ( P = @ ) . | 8 |
25411289 | results | Median ( @ % CI ) calculated liver reserves at baseline were @ ( @ , @ ) mol/g liver , with @ % > @ mol/g , the subtoxicity cutoff ; none were < @ mol/g , the deficiency cutoff . | 9 |
25411289 | results | The calculated bioconversion factor was @ g - carotene equivalents/@ g retinol by using the middle @ quintiles of change in TBRs from each group . | 10 |
25411289 | results | Serum retinol did not change in response to intervention ( P = @ ) but was reduced with elevated C-reactive protein ( P = @ ) and -@ - acid glycoprotein ( P = @ ) at baseline . | 11 |
25411289 | conclusions | - Carotene from maize was efficacious when consumed as a staple food in this population and could avoid the potential for hypervitaminosis A that was observed with the use of preformed VA from supplementation and fortification . | 12 |
25411289 | conclusions | Use of more sensitive methods other than serum retinol alone , such as isotope dilution , is required to accurately assess VA status , evaluate interventions , and investigate the interaction of VA status and infection . | 13 |
25411289 | conclusions | This trial was registered at clinicaltrials.gov as NCT@ . | 14 |
24224521 | background | Submassive pulmonary embolism ( PE ) has a low mortality rate but can degrade functional capacity . | 0 |
24224521 | objective | The present study aims to provide rationale , methodology , and initial findings of a multicentre , randomised trial of fibrinolysis for PE that used a composite end-point , including quality of life measures . | 1 |
24224521 | methods | This investigator-initiated study was funded by a contract between a corporate partner and the investigator 's hospital ( the prime site ) . | 2 |
24224521 | methods | The investigator was the Food and Drug Administration ( FDA ) sponsor . | 3 |
24224521 | methods | The prime site subcontracted , indemnified , and trained consortia members . | 4 |
24224521 | methods | Consenting , normotensive patients with PE and right ventricular strain ( by echocardiography or biomarkers ) received low-molecular-weight heparin and random assignment to a single bolus of tenecteplase or placebo in double-blinded fashion . | 5 |
24224521 | methods | The outcomes were : ( i ) in-hospital rate of intubation , vasopressor support , and major haemorrhage , or ( ii ) at @ days , death , recurrent PE , or composite that defined poor quality of life ( echocardiography , @ min walk test and surveys ) . | 6 |
24224521 | methods | The planned sample size was n = @ . | 7 |
24224521 | results | Eight sites enrolled @ patients over @ years . | 8 |
24224521 | results | The ratio of patients screened for each enrolled was @ to @ , equating to @ h screening time per patient enrolled . | 9 |
24224521 | results | Primary barrier to enrolment was the cost of screening . | 10 |
24224521 | results | Two patients died ( @ % , @ % CI -LSB- @-@ % -RSB- ) , one developed shock , but @ ( @ % , @ % CI : -LSB- @-@ % -RSB- ) had a poor quality of life . | 11 |
24224521 | conclusions | An investigator-initiated , FDA-regulated , multicentre trial of fibrinolysis for submassive PE was conducted , but was limited by screening costs and a low mortality rate . | 12 |
24224521 | conclusions | Quality of life measurements might represent a more important patient-centred end-point . | 13 |
25082132 | background | Crashes are the leading cause of death for teens , and parent-based interventions are a promising approach . | 0 |
25082132 | background | We assess the effectiveness of Steering Teens Safe , a parent-focused program to increase safe teen driving . | 1 |
25082132 | methods | Steering Teens Safe aimed to improve parental communication with teens about safe driving using motivational interviewing techniques in conjunction with @ safe driving lessons . | 2 |
25082132 | methods | A randomized controlled trial involved @ parent-teen dyads ( @ intervention and @ control ) . | 3 |
25082132 | methods | Intervention parents received a @-minute session to learn the program with four follow-up phone sessions , a DVD , and a workbook . | 4 |
25082132 | methods | Control parents received a standard brochure about safe driving . | 5 |
25082132 | methods | Scores were developed to measure teen-reported quantity and quality of parental communication about safe driving . | 6 |
25082132 | methods | The main outcome measure was a previously validated Risky Driving Score reported by teens . | 7 |
25082132 | methods | Because the Score was highly skewed , a generalized linear model based on a gamma distribution was used for analysis . | 8 |
25082132 | results | Intervention teens ranked their parent 's success in talking about driving safety higher than control teens ( p = @ ) and reported that their parents talked about more topics ( non-significant difference ) . | 9 |
25082132 | results | The Risky Driving Score was @ % lower in intervention compared to control teens ( @ % CI = @ , @ ) . | 10 |
25082132 | results | Interaction between communication quantity and the intervention was examined . | 11 |
25082132 | results | Intervention teens who reported more successful communication had a @ % lower Risky Driving Score ( @ % CI = @ , @ ) than control parents with less successful communication . | 12 |
25082132 | conclusions | This program had a positive although not strong effect , and it may hold the most promise in partnership with other programs , such as Driver 's Education or Graduated Driver 's License policies . | 13 |
24297946 | objective | Deep molecular response ( MR ( @ ) ) defines a subgroup of patients with chronic myeloid leukemia ( CML ) who may stay in unmaintained remission after treatment discontinuation . | 0 |
24297946 | objective | It is unclear how many patients achieve MR ( @ ) under different treatment modalities and whether MR ( @ ) predicts survival . | 1 |
24297946 | methods | Patients from the randomized CML-Study IV were analyzed for confirmed MR ( @ ) which was defined as @ log reduction of BCR-ABL on the international scale ( IS ) and determined by reverse transcriptase polymerase chain reaction in two consecutive analyses . | 2 |
24297946 | methods | Landmark analyses were performed to assess the impact of MR ( @ ) on survival . | 3 |
24297946 | results | Of @,@ randomly assigned patients , @,@ were assessable . | 4 |
24297946 | results | After a median observation time of @ months , @-year overall survival ( OS ) was @ % , @-year progression-free-survival was @ % , and @-year OS was @ % . | 5 |
24297946 | results | The cumulative incidence of MR ( @ ) after @ years was @ % ( median , @ years ) ; confirmed MR ( @ ) was @ % . | 6 |
24297946 | results | MR ( @ ) was reached more quickly with optimized high-dose imatinib than with imatinib @ mg/day ( P = @ ) . | 7 |
24297946 | results | Independent of treatment approach , confirmed MR ( @ ) at @ years predicted significantly higher survival probabilities than @ % to @ % IS , which corresponds to complete cytogenetic remission ( @-year OS , @ % v @ % ; P = @ ) . | 8 |
24297946 | results | High-dose imatinib and early major molecular remission predicted MR ( @ ) . | 9 |
24297946 | results | No patient with confirmed MR ( @ ) has experienced progression . | 10 |
24297946 | conclusions | MR ( @ ) is a new molecular predictor of long-term outcome , is reached by a majority of patients treated with imatinib , and is achieved more quickly with optimized high-dose imatinib , which may provide an improved therapeutic basis for treatment discontinuation in CML . | 11 |
25590323 | objective | To compare the efficacy and safety of endoscopic dacryocystorhinostomy ( En-DCR ) with different stent materials for lacrimal sac intubation in primary nasolacrimal ductal obstructions . | 0 |
25590323 | methods | Randomized controlled study with three parallel groups . | 1 |
25590323 | methods | Level of evidence is @b . | 2 |
25590323 | methods | A total of @ patients ( five bilateral ) with primary nasolacrimal duct obstruction ( NLDO ) at a tertiary referral center scheduled for En-DCR were to allocated into three stent groups with a sealed envelope and were randomized into three treatments : silicone , Prolene ( polypropylene ) , and otologic T-tube . | 3 |
25590323 | methods | Ophthalmology and otolaryngology clinics evaluated the patients preoperatively and postoperatively with endoscopes , lacrimal system syringing , and dacryocystography . | 4 |
25590323 | methods | The success of the stents was evaluated @ months after surgery with symptom relief and ostial patency . | 5 |
25590323 | methods | Complications were also noted . | 6 |
25590323 | results | The overall success rate of the En-DCR in the stent groups was @ % ( @/@ ) ; specifically , @ % ( @/@ ) with silicone , @ % ( @/@ ) with Prolene , and @ % ( @/@ ) with T-tube . | 7 |
25590323 | results | The efficacy of the procedures with the T-tube was significantly lower than that of the Prolene and silicone ( p = @ , ( @ ) test ) . | 8 |
25590323 | results | There were no significant differences between the silicone and Prolene ( p = @ , ( @ ) test ) . | 9 |
25590323 | results | Prolene was found to be related with orbital complications . | 10 |
25590323 | results | Spontaneous loss is a particular complication of otologic T-tube and highly portends to failure . | 11 |
25590323 | conclusions | The results of our study suggest that efficacy , defined as anatomic and functional success , is equally high for silicone and Prolene stents and lower for otologic T-tube in En-DCR . | 12 |
24751304 | background | Little is known about the longer-term effects of adjunctive benzodiazepines on symptom response during treatment in patients with bipolar disorders . | 0 |
24751304 | methods | The study sample consisted of @ patients with bipolar I or II disorder enrolled in a @-month , randomized , multi-site comparison of lithium - and quetiapine-based treatment . | 1 |
24751304 | methods | Changes in clinical measures ( BISS total and subscales , CGI-BP , and CGI-Efficacy Index ) were compared between participants who did and did not receive benzodiazepine treatment at baseline or during follow-up . | 2 |
24751304 | methods | Selected outcomes were also compared between patients who did and did not initiate benzodiazepines during follow-up using stabilized inverse probability weighted analyses . | 3 |
24751304 | results | Significant improvement in all outcome measures occurred within each benzodiazepine exposure group . | 4 |
24751304 | results | Benzodiazepine users ( at baseline or during follow-up ) experienced significantly less improvement in BISS total , BISS irritability , and CGI-BP scores than did benzodiazepine non-users . | 5 |