answer
stringlengths
1
16.1k
id
stringlengths
7
56
instruction
stringlengths
106
72.6k
ner_tags
sequence
text
stringlengths
5
72.4k
tokens
sequence
types
sequence
N - acetylcysteine inhibition, cytokine - induced E - selectin, VCAM-1 expression
59018_task2
Sentence: Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-other_name", "I-other_name", "O" ]
Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.
[ "Distinct", "mechanisms", "for", "N", "-", "acetylcysteine", "inhibition", "of", "cytokine", "-", "induced", "E", "-", "selectin", "and", "VCAM-1", "expression", "." ]
[ "other_name", "protein_molecule", "DNA_domain_or_region", "other_organic_compound", "DNA_molecule", "(OR RNA_molecule RNA_molecule)", "RNA_family_or_group", "protein_complex", "DNA_family_or_group", "amino_acid_monomer", "peptide", "lipid", "cell_type", "" ]
kidney transplantation is an umlsterm, treatment is an umlsterm, patients is an umlsterm, wit is an umlsterm, end - stage renal disease is an umlsterm, dialysis is an umlsterm, functions is an umlsterm, Transplantation is an umlsterm, dialysis is an umlsterm, quality of life is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, graft survival is an umlsterm, form is an umlsterm, transplant is an umlsterm, rejection is an umlsterm, nephropathy is an umlsterm, ages is an umlsterm, transplant recipients is an umlsterm, death is an umlsterm, patients is an umlsterm, grafts is an umlsterm, rejection is an umlsterm, arteries is an umlsterm, arterioles is an umlsterm, blood pressure is an umlsterm, hyperlipidemia is an umlsterm, drugs is an umlsterm, nephropathy is an umlsterm, complications is an umlsterm, transplant recipients is an umlsterm, immunosuppression is an umlsterm, viral is an umlsterm, malignant is an umlsterm, diseases is an umlsterm
MedizinischeKlinik.00950261.eng.abstr_task0
Sentence: Allogenic kidney transplantation is a widely established treatment option for patients wit end-stage renal disease to gain independency from dialysis and recovery off excretory and hormonal functions . Transplantation is superior to dialysis with respect to quality of life , morbidity and mortality . Improements in one-year graft survival have become evident during the last decades , but long-term outcome is not yet satisfying . The most common form of late transplant failure is chronic rejection or chronic allograft nephropathy , and as a consequence of higher ages of transplant recipients death of patients with functioning grafts . The histological hallmark of chronic rejection is intimal thickening of small arteries and arterioles , but the involved pathomechanisms are not well understood . Strict normalization of blood pressure and hyperlipidemia by drugs aims to prevent vascular alterations of chronic allograft nephropathy . In addition , in this overview some other late complications of renal transplant recipients are addressed which are associated to chronic immunosuppression , such as viral or malignant diseases . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]
Allogenic kidney transplantation is a widely established treatment option for patients wit end-stage renal disease to gain independency from dialysis and recovery off excretory and hormonal functions . Transplantation is superior to dialysis with respect to quality of life , morbidity and mortality . Improements in one-year graft survival have become evident during the last decades , but long-term outcome is not yet satisfying . The most common form of late transplant failure is chronic rejection or chronic allograft nephropathy , and as a consequence of higher ages of transplant recipients death of patients with functioning grafts . The histological hallmark of chronic rejection is intimal thickening of small arteries and arterioles , but the involved pathomechanisms are not well understood . Strict normalization of blood pressure and hyperlipidemia by drugs aims to prevent vascular alterations of chronic allograft nephropathy . In addition , in this overview some other late complications of renal transplant recipients are addressed which are associated to chronic immunosuppression , such as viral or malignant diseases .
[ "Allogenic", "kidney", "transplantation", "is", "a", "widely", "established", "treatment", "option", "for", "patients", "wit", "end", "-", "stage", "renal", "disease", "to", "gain", "independency", "from", "dialysis", "and", "recovery", "off", "excretory", "and", "hormonal", "functions", ".", "Transplantation", "is", "superior", "to", "dialysis", "with", "respect", "to", "quality", "of", "life", ",", "morbidity", "and", "mortality", ".", "Improements", "in", "one", "-", "year", "graft", "survival", "have", "become", "evident", "during", "the", "last", "decades", ",", "but", "long", "-", "term", "outcome", "is", "not", "yet", "satisfying", ".", "The", "most", "common", "form", "of", "late", "transplant", "failure", "is", "chronic", "rejection", "or", "chronic", "allograft", "nephropathy", ",", "and", "as", "a", "consequence", "of", "higher", "ages", "of", "transplant", "recipients", "death", "of", "patients", "with", "functioning", "grafts", ".", "The", "histological", "hallmark", "of", "chronic", "rejection", "is", "intimal", "thickening", "of", "small", "arteries", "and", "arterioles", ",", "but", "the", "involved", "pathomechanisms", "are", "not", "well", "understood", ".", "Strict", "normalization", "of", "blood", "pressure", "and", "hyperlipidemia", "by", "drugs", "aims", "to", "prevent", "vascular", "alterations", "of", "chronic", "allograft", "nephropathy", ".", "In", "addition", ",", "in", "this", "overview", "some", "other", "late", "complications", "of", "renal", "transplant", "recipients", "are", "addressed", "which", "are", "associated", "to", "chronic", "immunosuppression", ",", "such", "as", "viral", "or", "malignant", "diseases", "." ]
[ "umlsterm" ]
kidney transplantation is an umlsterm, treatment is an umlsterm, patients is an umlsterm, wit is an umlsterm, end - stage renal disease is an umlsterm, dialysis is an umlsterm, functions is an umlsterm, Transplantation is an umlsterm, dialysis is an umlsterm, quality of life is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, graft survival is an umlsterm, form is an umlsterm, transplant is an umlsterm, rejection is an umlsterm, nephropathy is an umlsterm, ages is an umlsterm, transplant recipients is an umlsterm, death is an umlsterm, patients is an umlsterm, grafts is an umlsterm, rejection is an umlsterm, arteries is an umlsterm, arterioles is an umlsterm, blood pressure is an umlsterm, hyperlipidemia is an umlsterm, drugs is an umlsterm, nephropathy is an umlsterm, complications is an umlsterm, transplant recipients is an umlsterm, immunosuppression is an umlsterm, viral is an umlsterm, malignant is an umlsterm, diseases is an umlsterm
MedizinischeKlinik.00950261.eng.abstr_task1
Sentence: Allogenic kidney transplantation is a widely established treatment option for patients wit end-stage renal disease to gain independency from dialysis and recovery off excretory and hormonal functions . Transplantation is superior to dialysis with respect to quality of life , morbidity and mortality . Improements in one-year graft survival have become evident during the last decades , but long-term outcome is not yet satisfying . The most common form of late transplant failure is chronic rejection or chronic allograft nephropathy , and as a consequence of higher ages of transplant recipients death of patients with functioning grafts . The histological hallmark of chronic rejection is intimal thickening of small arteries and arterioles , but the involved pathomechanisms are not well understood . Strict normalization of blood pressure and hyperlipidemia by drugs aims to prevent vascular alterations of chronic allograft nephropathy . In addition , in this overview some other late complications of renal transplant recipients are addressed which are associated to chronic immunosuppression , such as viral or malignant diseases . Instructions: please typing these entity words according to sentence: kidney transplantation, treatment, patients, wit, end - stage renal disease, dialysis, functions, Transplantation, dialysis, quality of life, morbidity, mortality, graft survival, form, transplant, rejection, nephropathy, ages, transplant recipients, death, patients, grafts, rejection, arteries, arterioles, blood pressure, hyperlipidemia, drugs, nephropathy, complications, transplant recipients, immunosuppression, viral, malignant, diseases Options: umlsterm
[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]
Allogenic kidney transplantation is a widely established treatment option for patients wit end-stage renal disease to gain independency from dialysis and recovery off excretory and hormonal functions . Transplantation is superior to dialysis with respect to quality of life , morbidity and mortality . Improements in one-year graft survival have become evident during the last decades , but long-term outcome is not yet satisfying . The most common form of late transplant failure is chronic rejection or chronic allograft nephropathy , and as a consequence of higher ages of transplant recipients death of patients with functioning grafts . The histological hallmark of chronic rejection is intimal thickening of small arteries and arterioles , but the involved pathomechanisms are not well understood . Strict normalization of blood pressure and hyperlipidemia by drugs aims to prevent vascular alterations of chronic allograft nephropathy . In addition , in this overview some other late complications of renal transplant recipients are addressed which are associated to chronic immunosuppression , such as viral or malignant diseases .
[ "Allogenic", "kidney", "transplantation", "is", "a", "widely", "established", "treatment", "option", "for", "patients", "wit", "end", "-", "stage", "renal", "disease", "to", "gain", "independency", "from", "dialysis", "and", "recovery", "off", "excretory", "and", "hormonal", "functions", ".", "Transplantation", "is", "superior", "to", "dialysis", "with", "respect", "to", "quality", "of", "life", ",", "morbidity", "and", "mortality", ".", "Improements", "in", "one", "-", "year", "graft", "survival", "have", "become", "evident", "during", "the", "last", "decades", ",", "but", "long", "-", "term", "outcome", "is", "not", "yet", "satisfying", ".", "The", "most", "common", "form", "of", "late", "transplant", "failure", "is", "chronic", "rejection", "or", "chronic", "allograft", "nephropathy", ",", "and", "as", "a", "consequence", "of", "higher", "ages", "of", "transplant", "recipients", "death", "of", "patients", "with", "functioning", "grafts", ".", "The", "histological", "hallmark", "of", "chronic", "rejection", "is", "intimal", "thickening", "of", "small", "arteries", "and", "arterioles", ",", "but", "the", "involved", "pathomechanisms", "are", "not", "well", "understood", ".", "Strict", "normalization", "of", "blood", "pressure", "and", "hyperlipidemia", "by", "drugs", "aims", "to", "prevent", "vascular", "alterations", "of", "chronic", "allograft", "nephropathy", ".", "In", "addition", ",", "in", "this", "overview", "some", "other", "late", "complications", "of", "renal", "transplant", "recipients", "are", "addressed", "which", "are", "associated", "to", "chronic", "immunosuppression", ",", "such", "as", "viral", "or", "malignant", "diseases", "." ]
[ "umlsterm" ]
kidney transplantation, treatment, patients, wit, end - stage renal disease, dialysis, functions, Transplantation, dialysis, quality of life, morbidity, mortality, graft survival, form, transplant, rejection, nephropathy, ages, transplant recipients, death, patients, grafts, rejection, arteries, arterioles, blood pressure, hyperlipidemia, drugs, nephropathy, complications, transplant recipients, immunosuppression, viral, malignant, diseases
MedizinischeKlinik.00950261.eng.abstr_task2
Sentence: Allogenic kidney transplantation is a widely established treatment option for patients wit end-stage renal disease to gain independency from dialysis and recovery off excretory and hormonal functions . Transplantation is superior to dialysis with respect to quality of life , morbidity and mortality . Improements in one-year graft survival have become evident during the last decades , but long-term outcome is not yet satisfying . The most common form of late transplant failure is chronic rejection or chronic allograft nephropathy , and as a consequence of higher ages of transplant recipients death of patients with functioning grafts . The histological hallmark of chronic rejection is intimal thickening of small arteries and arterioles , but the involved pathomechanisms are not well understood . Strict normalization of blood pressure and hyperlipidemia by drugs aims to prevent vascular alterations of chronic allograft nephropathy . In addition , in this overview some other late complications of renal transplant recipients are addressed which are associated to chronic immunosuppression , such as viral or malignant diseases . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]
Allogenic kidney transplantation is a widely established treatment option for patients wit end-stage renal disease to gain independency from dialysis and recovery off excretory and hormonal functions . Transplantation is superior to dialysis with respect to quality of life , morbidity and mortality . Improements in one-year graft survival have become evident during the last decades , but long-term outcome is not yet satisfying . The most common form of late transplant failure is chronic rejection or chronic allograft nephropathy , and as a consequence of higher ages of transplant recipients death of patients with functioning grafts . The histological hallmark of chronic rejection is intimal thickening of small arteries and arterioles , but the involved pathomechanisms are not well understood . Strict normalization of blood pressure and hyperlipidemia by drugs aims to prevent vascular alterations of chronic allograft nephropathy . In addition , in this overview some other late complications of renal transplant recipients are addressed which are associated to chronic immunosuppression , such as viral or malignant diseases .
[ "Allogenic", "kidney", "transplantation", "is", "a", "widely", "established", "treatment", "option", "for", "patients", "wit", "end", "-", "stage", "renal", "disease", "to", "gain", "independency", "from", "dialysis", "and", "recovery", "off", "excretory", "and", "hormonal", "functions", ".", "Transplantation", "is", "superior", "to", "dialysis", "with", "respect", "to", "quality", "of", "life", ",", "morbidity", "and", "mortality", ".", "Improements", "in", "one", "-", "year", "graft", "survival", "have", "become", "evident", "during", "the", "last", "decades", ",", "but", "long", "-", "term", "outcome", "is", "not", "yet", "satisfying", ".", "The", "most", "common", "form", "of", "late", "transplant", "failure", "is", "chronic", "rejection", "or", "chronic", "allograft", "nephropathy", ",", "and", "as", "a", "consequence", "of", "higher", "ages", "of", "transplant", "recipients", "death", "of", "patients", "with", "functioning", "grafts", ".", "The", "histological", "hallmark", "of", "chronic", "rejection", "is", "intimal", "thickening", "of", "small", "arteries", "and", "arterioles", ",", "but", "the", "involved", "pathomechanisms", "are", "not", "well", "understood", ".", "Strict", "normalization", "of", "blood", "pressure", "and", "hyperlipidemia", "by", "drugs", "aims", "to", "prevent", "vascular", "alterations", "of", "chronic", "allograft", "nephropathy", ".", "In", "addition", ",", "in", "this", "overview", "some", "other", "late", "complications", "of", "renal", "transplant", "recipients", "are", "addressed", "which", "are", "associated", "to", "chronic", "immunosuppression", ",", "such", "as", "viral", "or", "malignant", "diseases", "." ]
[ "umlsterm" ]
flea is an umlsterm, humans is an umlsterm, arthropods is an umlsterm, cause is an umlsterm, origin is an umlsterm, Bites is an umlsterm, animal is an umlsterm, fleas is an umlsterm, people is an umlsterm, wild animals is an umlsterm, dermatosis is an umlsterm, flea is an umlsterm, canis is an umlsterm, felis is an umlsterm, human is an umlsterm, skin is an umlsterm, symptoms is an umlsterm, Flea is an umlsterm, role is an umlsterm, flea is an umlsterm, disease vectors is an umlsterm
DerHautarzt.70480714.eng.abstr_task0
Sentence: Different flea species may infest humans temporarily . Such arthropods should be considered as a possible cause of erythematous and pruritic papules and nodules of unclear origin . Bites from animal fleas can be seen in people with close contact to domestic or wild animals . This dermatosis may often be misdiagnosed . Several flea species including Pulex irritans , Ctenocephalides canis , Ctenocephalides felis , Ceratophyllus gallinae , Ceratophyllus columbae and Archaeopsylla erinacei may infest human skin , causing symptoms . Flea bite-allergy and the role of various flea species as disease vectors are also discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]
Different flea species may infest humans temporarily . Such arthropods should be considered as a possible cause of erythematous and pruritic papules and nodules of unclear origin . Bites from animal fleas can be seen in people with close contact to domestic or wild animals . This dermatosis may often be misdiagnosed . Several flea species including Pulex irritans , Ctenocephalides canis , Ctenocephalides felis , Ceratophyllus gallinae , Ceratophyllus columbae and Archaeopsylla erinacei may infest human skin , causing symptoms . Flea bite-allergy and the role of various flea species as disease vectors are also discussed .
[ "Different", "flea", "species", "may", "infest", "humans", "temporarily", ".", "Such", "arthropods", "should", "be", "considered", "as", "a", "possible", "cause", "of", "erythematous", "and", "pruritic", "papules", "and", "nodules", "of", "unclear", "origin", ".", "Bites", "from", "animal", "fleas", "can", "be", "seen", "in", "people", "with", "close", "contact", "to", "domestic", "or", "wild", "animals", ".", "This", "dermatosis", "may", "often", "be", "misdiagnosed", ".", "Several", "flea", "species", "including", "Pulex", "irritans", ",", "Ctenocephalides", "canis", ",", "Ctenocephalides", "felis", ",", "Ceratophyllus", "gallinae", ",", "Ceratophyllus", "columbae", "and", "Archaeopsylla", "erinacei", "may", "infest", "human", "skin", ",", "causing", "symptoms", ".", "Flea", "bite", "-", "allergy", "and", "the", "role", "of", "various", "flea", "species", "as", "disease", "vectors", "are", "also", "discussed", "." ]
[ "umlsterm" ]
flea is an umlsterm, humans is an umlsterm, arthropods is an umlsterm, cause is an umlsterm, origin is an umlsterm, Bites is an umlsterm, animal is an umlsterm, fleas is an umlsterm, people is an umlsterm, wild animals is an umlsterm, dermatosis is an umlsterm, flea is an umlsterm, canis is an umlsterm, felis is an umlsterm, human is an umlsterm, skin is an umlsterm, symptoms is an umlsterm, Flea is an umlsterm, role is an umlsterm, flea is an umlsterm, disease vectors is an umlsterm
DerHautarzt.70480714.eng.abstr_task1
Sentence: Different flea species may infest humans temporarily . Such arthropods should be considered as a possible cause of erythematous and pruritic papules and nodules of unclear origin . Bites from animal fleas can be seen in people with close contact to domestic or wild animals . This dermatosis may often be misdiagnosed . Several flea species including Pulex irritans , Ctenocephalides canis , Ctenocephalides felis , Ceratophyllus gallinae , Ceratophyllus columbae and Archaeopsylla erinacei may infest human skin , causing symptoms . Flea bite-allergy and the role of various flea species as disease vectors are also discussed . Instructions: please typing these entity words according to sentence: flea, humans, arthropods, cause, origin, Bites, animal, fleas, people, wild animals, dermatosis, flea, canis, felis, human, skin, symptoms, Flea, role, flea, disease vectors Options: umlsterm
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]
Different flea species may infest humans temporarily . Such arthropods should be considered as a possible cause of erythematous and pruritic papules and nodules of unclear origin . Bites from animal fleas can be seen in people with close contact to domestic or wild animals . This dermatosis may often be misdiagnosed . Several flea species including Pulex irritans , Ctenocephalides canis , Ctenocephalides felis , Ceratophyllus gallinae , Ceratophyllus columbae and Archaeopsylla erinacei may infest human skin , causing symptoms . Flea bite-allergy and the role of various flea species as disease vectors are also discussed .
[ "Different", "flea", "species", "may", "infest", "humans", "temporarily", ".", "Such", "arthropods", "should", "be", "considered", "as", "a", "possible", "cause", "of", "erythematous", "and", "pruritic", "papules", "and", "nodules", "of", "unclear", "origin", ".", "Bites", "from", "animal", "fleas", "can", "be", "seen", "in", "people", "with", "close", "contact", "to", "domestic", "or", "wild", "animals", ".", "This", "dermatosis", "may", "often", "be", "misdiagnosed", ".", "Several", "flea", "species", "including", "Pulex", "irritans", ",", "Ctenocephalides", "canis", ",", "Ctenocephalides", "felis", ",", "Ceratophyllus", "gallinae", ",", "Ceratophyllus", "columbae", "and", "Archaeopsylla", "erinacei", "may", "infest", "human", "skin", ",", "causing", "symptoms", ".", "Flea", "bite", "-", "allergy", "and", "the", "role", "of", "various", "flea", "species", "as", "disease", "vectors", "are", "also", "discussed", "." ]
[ "umlsterm" ]
flea, humans, arthropods, cause, origin, Bites, animal, fleas, people, wild animals, dermatosis, flea, canis, felis, human, skin, symptoms, Flea, role, flea, disease vectors
DerHautarzt.70480714.eng.abstr_task2
Sentence: Different flea species may infest humans temporarily . Such arthropods should be considered as a possible cause of erythematous and pruritic papules and nodules of unclear origin . Bites from animal fleas can be seen in people with close contact to domestic or wild animals . This dermatosis may often be misdiagnosed . Several flea species including Pulex irritans , Ctenocephalides canis , Ctenocephalides felis , Ceratophyllus gallinae , Ceratophyllus columbae and Archaeopsylla erinacei may infest human skin , causing symptoms . Flea bite-allergy and the role of various flea species as disease vectors are also discussed . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]
Different flea species may infest humans temporarily . Such arthropods should be considered as a possible cause of erythematous and pruritic papules and nodules of unclear origin . Bites from animal fleas can be seen in people with close contact to domestic or wild animals . This dermatosis may often be misdiagnosed . Several flea species including Pulex irritans , Ctenocephalides canis , Ctenocephalides felis , Ceratophyllus gallinae , Ceratophyllus columbae and Archaeopsylla erinacei may infest human skin , causing symptoms . Flea bite-allergy and the role of various flea species as disease vectors are also discussed .
[ "Different", "flea", "species", "may", "infest", "humans", "temporarily", ".", "Such", "arthropods", "should", "be", "considered", "as", "a", "possible", "cause", "of", "erythematous", "and", "pruritic", "papules", "and", "nodules", "of", "unclear", "origin", ".", "Bites", "from", "animal", "fleas", "can", "be", "seen", "in", "people", "with", "close", "contact", "to", "domestic", "or", "wild", "animals", ".", "This", "dermatosis", "may", "often", "be", "misdiagnosed", ".", "Several", "flea", "species", "including", "Pulex", "irritans", ",", "Ctenocephalides", "canis", ",", "Ctenocephalides", "felis", ",", "Ceratophyllus", "gallinae", ",", "Ceratophyllus", "columbae", "and", "Archaeopsylla", "erinacei", "may", "infest", "human", "skin", ",", "causing", "symptoms", ".", "Flea", "bite", "-", "allergy", "and", "the", "role", "of", "various", "flea", "species", "as", "disease", "vectors", "are", "also", "discussed", "." ]
[ "umlsterm" ]
childhood leukaemia is a Cancer
PMC-2579698-caption-02_task0
Sentence: Characteristics of cases with childhood leukaemia (n=162) and matched controls (n=2125), all registered within 3 months of birth Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Cancer
[ "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Characteristics of cases with childhood leukaemia (n=162) and matched controls (n=2125), all registered within 3 months of birth
[ "Characteristics", "of", "cases", "with", "childhood", "leukaemia", "(", "n=162", ")", "and", "matched", "controls", "(", "n=2125", ")", ",", "all", "registered", "within", "3", "months", "of", "birth", "\n" ]
[ "Cancer" ]
childhood leukaemia is a Cancer
PMC-2579698-caption-02_task1
Sentence: Characteristics of cases with childhood leukaemia (n=162) and matched controls (n=2125), all registered within 3 months of birth Instructions: please typing these entity words according to sentence: childhood leukaemia Options: Cancer
[ "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Characteristics of cases with childhood leukaemia (n=162) and matched controls (n=2125), all registered within 3 months of birth
[ "Characteristics", "of", "cases", "with", "childhood", "leukaemia", "(", "n=162", ")", "and", "matched", "controls", "(", "n=2125", ")", ",", "all", "registered", "within", "3", "months", "of", "birth", "\n" ]
[ "Cancer" ]
childhood leukaemia
PMC-2579698-caption-02_task2
Sentence: Characteristics of cases with childhood leukaemia (n=162) and matched controls (n=2125), all registered within 3 months of birth Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Characteristics of cases with childhood leukaemia (n=162) and matched controls (n=2125), all registered within 3 months of birth
[ "Characteristics", "of", "cases", "with", "childhood", "leukaemia", "(", "n=162", ")", "and", "matched", "controls", "(", "n=2125", ")", ",", "all", "registered", "within", "3", "months", "of", "birth", "\n" ]
[ "Cancer" ]
Analyse is an umlsterm, Risikofaktoren is an umlsterm, Oesterreich is an umlsterm, Methodik is an umlsterm, Geburten- is an umlsterm, Einzelgeburten is an umlsterm, Lebensmonat is an umlsterm, SIDS is an umlsterm, Todesursachen is an umlsterm, SIDS is an umlsterm, relative Risiken is an umlsterm, Risikofaktoren is an umlsterm, Risikofaktoren is an umlsterm, relative Risiko is an umlsterm, Muettern is an umlsterm, Frauen is an umlsterm, SIDS is an umlsterm, SIDS is an umlsterm, Rolle is an umlsterm, Risikofaktoren is an umlsterm, SIDS is an umlsterm
MonatsschriftKinderheilkunde.71450613.ger.abstr_task0
Sentence: Fragestellung : Analyse und Vergleich der Bedeutung sozialer Risikofaktoren fuer die SIDS- und Non-SIDS-Sterblichkeit in Oesterreich . Methodik : Die verknuepften Geburten- und Sterbedatensaetze der Jahrgaenge 1984 bis 1993 umfassen 880 601 Neugeborene ( Einzelgeburten ) , die das erste Lebensmonat ueberleben . Davon verstarben im ersten Lebensjahr 1070 Saeuglinge an SIDS , 1919 an sonstigen Todesursachen ( Non-SIDS ) . Fuer SIDS und Non-SIDS werden einfache und multivariate relative Risiken ( RR ) und 95 %-Konfidenzintervalle fuer soziale Risikofaktoren unter Kontrolle demographischer Merkmale und des Geburtsgewichts ermittelt . Ergebnisse : Soziale Risikofaktoren lassen sich sowohl fuer die postneonatale SIDS- als auch fuer die Non-SIDS-Sterblichkeit nachweisen . So betraegt das relative Risiko bei Muettern mit Pflichtschulbildung gegenueber hoeher gebildeten Frauen bei SIDS 1,45 . Nahezu gleich gross ist der Einfluss auf die Non-SIDS-Mortalitaet ( RR = 1,48 ) . Bei Gastarbeiterinnen ist das SIDS-Risiko deutlich geringer als bei Oesterreicherinnen ( RR = 0,33 ) . In Grossstaedten ist das SIDS-Risiko hoeher als in den uebrigen Gemeinden ( RR = 1,63 ) , waehrend das Non-SIDS-Risiko hier geringer ist ( RR = 0,89 ) . Schlussfolgerungen : Soziale Benachteiligung spielt fuer SIDS eine grosse Rolle . Dies gilt aber in gleicher Weise fuer die postneonatale Non-SIDS-Sterblichkeit . Massnahmen zur Kompensation sozialer Risikofaktoren sollten daher nicht auf SIDS beschraenkt bleiben , sondern in allgemeine Praeventionsinitiativen eingebunden werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Fragestellung : Analyse und Vergleich der Bedeutung sozialer Risikofaktoren fuer die SIDS- und Non-SIDS-Sterblichkeit in Oesterreich . Methodik : Die verknuepften Geburten- und Sterbedatensaetze der Jahrgaenge 1984 bis 1993 umfassen 880 601 Neugeborene ( Einzelgeburten ) , die das erste Lebensmonat ueberleben . Davon verstarben im ersten Lebensjahr 1070 Saeuglinge an SIDS , 1919 an sonstigen Todesursachen ( Non-SIDS ) . Fuer SIDS und Non-SIDS werden einfache und multivariate relative Risiken ( RR ) und 95 %-Konfidenzintervalle fuer soziale Risikofaktoren unter Kontrolle demographischer Merkmale und des Geburtsgewichts ermittelt . Ergebnisse : Soziale Risikofaktoren lassen sich sowohl fuer die postneonatale SIDS- als auch fuer die Non-SIDS-Sterblichkeit nachweisen . So betraegt das relative Risiko bei Muettern mit Pflichtschulbildung gegenueber hoeher gebildeten Frauen bei SIDS 1,45 . Nahezu gleich gross ist der Einfluss auf die Non-SIDS-Mortalitaet ( RR = 1,48 ) . Bei Gastarbeiterinnen ist das SIDS-Risiko deutlich geringer als bei Oesterreicherinnen ( RR = 0,33 ) . In Grossstaedten ist das SIDS-Risiko hoeher als in den uebrigen Gemeinden ( RR = 1,63 ) , waehrend das Non-SIDS-Risiko hier geringer ist ( RR = 0,89 ) . Schlussfolgerungen : Soziale Benachteiligung spielt fuer SIDS eine grosse Rolle . Dies gilt aber in gleicher Weise fuer die postneonatale Non-SIDS-Sterblichkeit . Massnahmen zur Kompensation sozialer Risikofaktoren sollten daher nicht auf SIDS beschraenkt bleiben , sondern in allgemeine Praeventionsinitiativen eingebunden werden .
[ "Fragestellung", ":", "Analyse", "und", "Vergleich", "der", "Bedeutung", "sozialer", "Risikofaktoren", "fuer", "die", "SIDS-", "und", "Non", "-", "SIDS", "-", "Sterblichkeit", "in", "Oesterreich", ".", "Methodik", ":", "Die", "verknuepften", "Geburten-", "und", "Sterbedatensaetze", "der", "Jahrgaenge", "1984", "bis", "1993", "umfassen", "880", "601", "Neugeborene", "(", "Einzelgeburten", ")", ",", "die", "das", "erste", "Lebensmonat", "ueberleben", ".", "Davon", "verstarben", "im", "ersten", "Lebensjahr", "1070", "Saeuglinge", "an", "SIDS", ",", "1919", "an", "sonstigen", "Todesursachen", "(", "Non", "-", "SIDS", ")", ".", "Fuer", "SIDS", "und", "Non", "-", "SIDS", "werden", "einfache", "und", "multivariate", "relative", "Risiken", "(", "RR", ")", "und", "95", "%", "-Konfidenzintervalle", "fuer", "soziale", "Risikofaktoren", "unter", "Kontrolle", "demographischer", "Merkmale", "und", "des", "Geburtsgewichts", "ermittelt", ".", "Ergebnisse", ":", "Soziale", "Risikofaktoren", "lassen", "sich", "sowohl", "fuer", "die", "postneonatale", "SIDS-", "als", "auch", "fuer", "die", "Non", "-", "SIDS", "-", "Sterblichkeit", "nachweisen", ".", "So", "betraegt", "das", "relative", "Risiko", "bei", "Muettern", "mit", "Pflichtschulbildung", "gegenueber", "hoeher", "gebildeten", "Frauen", "bei", "SIDS", "1,45", ".", "Nahezu", "gleich", "gross", "ist", "der", "Einfluss", "auf", "die", "Non", "-", "SIDS", "-", "Mortalitaet", "(", "RR", "=", "1,48", ")", ".", "Bei", "Gastarbeiterinnen", "ist", "das", "SIDS", "-", "Risiko", "deutlich", "geringer", "als", "bei", "Oesterreicherinnen", "(", "RR", "=", "0,33", ")", ".", "In", "Grossstaedten", "ist", "das", "SIDS", "-", "Risiko", "hoeher", "als", "in", "den", "uebrigen", "Gemeinden", "(", "RR", "=", "1,63", ")", ",", "waehrend", "das", "Non", "-", "SIDS", "-", "Risiko", "hier", "geringer", "ist", "(", "RR", "=", "0,89", ")", ".", "Schlussfolgerungen", ":", "Soziale", "Benachteiligung", "spielt", "fuer", "SIDS", "eine", "grosse", "Rolle", ".", "Dies", "gilt", "aber", "in", "gleicher", "Weise", "fuer", "die", "postneonatale", "Non", "-", "SIDS", "-", "Sterblichkeit", ".", "Massnahmen", "zur", "Kompensation", "sozialer", "Risikofaktoren", "sollten", "daher", "nicht", "auf", "SIDS", "beschraenkt", "bleiben", ",", "sondern", "in", "allgemeine", "Praeventionsinitiativen", "eingebunden", "werden", "." ]
[ "umlsterm" ]
Analyse is an umlsterm, Risikofaktoren is an umlsterm, Oesterreich is an umlsterm, Methodik is an umlsterm, Geburten- is an umlsterm, Einzelgeburten is an umlsterm, Lebensmonat is an umlsterm, SIDS is an umlsterm, Todesursachen is an umlsterm, SIDS is an umlsterm, relative Risiken is an umlsterm, Risikofaktoren is an umlsterm, Risikofaktoren is an umlsterm, relative Risiko is an umlsterm, Muettern is an umlsterm, Frauen is an umlsterm, SIDS is an umlsterm, SIDS is an umlsterm, Rolle is an umlsterm, Risikofaktoren is an umlsterm, SIDS is an umlsterm
MonatsschriftKinderheilkunde.71450613.ger.abstr_task1
Sentence: Fragestellung : Analyse und Vergleich der Bedeutung sozialer Risikofaktoren fuer die SIDS- und Non-SIDS-Sterblichkeit in Oesterreich . Methodik : Die verknuepften Geburten- und Sterbedatensaetze der Jahrgaenge 1984 bis 1993 umfassen 880 601 Neugeborene ( Einzelgeburten ) , die das erste Lebensmonat ueberleben . Davon verstarben im ersten Lebensjahr 1070 Saeuglinge an SIDS , 1919 an sonstigen Todesursachen ( Non-SIDS ) . Fuer SIDS und Non-SIDS werden einfache und multivariate relative Risiken ( RR ) und 95 %-Konfidenzintervalle fuer soziale Risikofaktoren unter Kontrolle demographischer Merkmale und des Geburtsgewichts ermittelt . Ergebnisse : Soziale Risikofaktoren lassen sich sowohl fuer die postneonatale SIDS- als auch fuer die Non-SIDS-Sterblichkeit nachweisen . So betraegt das relative Risiko bei Muettern mit Pflichtschulbildung gegenueber hoeher gebildeten Frauen bei SIDS 1,45 . Nahezu gleich gross ist der Einfluss auf die Non-SIDS-Mortalitaet ( RR = 1,48 ) . Bei Gastarbeiterinnen ist das SIDS-Risiko deutlich geringer als bei Oesterreicherinnen ( RR = 0,33 ) . In Grossstaedten ist das SIDS-Risiko hoeher als in den uebrigen Gemeinden ( RR = 1,63 ) , waehrend das Non-SIDS-Risiko hier geringer ist ( RR = 0,89 ) . Schlussfolgerungen : Soziale Benachteiligung spielt fuer SIDS eine grosse Rolle . Dies gilt aber in gleicher Weise fuer die postneonatale Non-SIDS-Sterblichkeit . Massnahmen zur Kompensation sozialer Risikofaktoren sollten daher nicht auf SIDS beschraenkt bleiben , sondern in allgemeine Praeventionsinitiativen eingebunden werden . Instructions: please typing these entity words according to sentence: Analyse, Risikofaktoren, Oesterreich, Methodik, Geburten-, Einzelgeburten, Lebensmonat, SIDS, Todesursachen, SIDS, relative Risiken, Risikofaktoren, Risikofaktoren, relative Risiko, Muettern, Frauen, SIDS, SIDS, Rolle, Risikofaktoren, SIDS Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Fragestellung : Analyse und Vergleich der Bedeutung sozialer Risikofaktoren fuer die SIDS- und Non-SIDS-Sterblichkeit in Oesterreich . Methodik : Die verknuepften Geburten- und Sterbedatensaetze der Jahrgaenge 1984 bis 1993 umfassen 880 601 Neugeborene ( Einzelgeburten ) , die das erste Lebensmonat ueberleben . Davon verstarben im ersten Lebensjahr 1070 Saeuglinge an SIDS , 1919 an sonstigen Todesursachen ( Non-SIDS ) . Fuer SIDS und Non-SIDS werden einfache und multivariate relative Risiken ( RR ) und 95 %-Konfidenzintervalle fuer soziale Risikofaktoren unter Kontrolle demographischer Merkmale und des Geburtsgewichts ermittelt . Ergebnisse : Soziale Risikofaktoren lassen sich sowohl fuer die postneonatale SIDS- als auch fuer die Non-SIDS-Sterblichkeit nachweisen . So betraegt das relative Risiko bei Muettern mit Pflichtschulbildung gegenueber hoeher gebildeten Frauen bei SIDS 1,45 . Nahezu gleich gross ist der Einfluss auf die Non-SIDS-Mortalitaet ( RR = 1,48 ) . Bei Gastarbeiterinnen ist das SIDS-Risiko deutlich geringer als bei Oesterreicherinnen ( RR = 0,33 ) . In Grossstaedten ist das SIDS-Risiko hoeher als in den uebrigen Gemeinden ( RR = 1,63 ) , waehrend das Non-SIDS-Risiko hier geringer ist ( RR = 0,89 ) . Schlussfolgerungen : Soziale Benachteiligung spielt fuer SIDS eine grosse Rolle . Dies gilt aber in gleicher Weise fuer die postneonatale Non-SIDS-Sterblichkeit . Massnahmen zur Kompensation sozialer Risikofaktoren sollten daher nicht auf SIDS beschraenkt bleiben , sondern in allgemeine Praeventionsinitiativen eingebunden werden .
[ "Fragestellung", ":", "Analyse", "und", "Vergleich", "der", "Bedeutung", "sozialer", "Risikofaktoren", "fuer", "die", "SIDS-", "und", "Non", "-", "SIDS", "-", "Sterblichkeit", "in", "Oesterreich", ".", "Methodik", ":", "Die", "verknuepften", "Geburten-", "und", "Sterbedatensaetze", "der", "Jahrgaenge", "1984", "bis", "1993", "umfassen", "880", "601", "Neugeborene", "(", "Einzelgeburten", ")", ",", "die", "das", "erste", "Lebensmonat", "ueberleben", ".", "Davon", "verstarben", "im", "ersten", "Lebensjahr", "1070", "Saeuglinge", "an", "SIDS", ",", "1919", "an", "sonstigen", "Todesursachen", "(", "Non", "-", "SIDS", ")", ".", "Fuer", "SIDS", "und", "Non", "-", "SIDS", "werden", "einfache", "und", "multivariate", "relative", "Risiken", "(", "RR", ")", "und", "95", "%", "-Konfidenzintervalle", "fuer", "soziale", "Risikofaktoren", "unter", "Kontrolle", "demographischer", "Merkmale", "und", "des", "Geburtsgewichts", "ermittelt", ".", "Ergebnisse", ":", "Soziale", "Risikofaktoren", "lassen", "sich", "sowohl", "fuer", "die", "postneonatale", "SIDS-", "als", "auch", "fuer", "die", "Non", "-", "SIDS", "-", "Sterblichkeit", "nachweisen", ".", "So", "betraegt", "das", "relative", "Risiko", "bei", "Muettern", "mit", "Pflichtschulbildung", "gegenueber", "hoeher", "gebildeten", "Frauen", "bei", "SIDS", "1,45", ".", "Nahezu", "gleich", "gross", "ist", "der", "Einfluss", "auf", "die", "Non", "-", "SIDS", "-", "Mortalitaet", "(", "RR", "=", "1,48", ")", ".", "Bei", "Gastarbeiterinnen", "ist", "das", "SIDS", "-", "Risiko", "deutlich", "geringer", "als", "bei", "Oesterreicherinnen", "(", "RR", "=", "0,33", ")", ".", "In", "Grossstaedten", "ist", "das", "SIDS", "-", "Risiko", "hoeher", "als", "in", "den", "uebrigen", "Gemeinden", "(", "RR", "=", "1,63", ")", ",", "waehrend", "das", "Non", "-", "SIDS", "-", "Risiko", "hier", "geringer", "ist", "(", "RR", "=", "0,89", ")", ".", "Schlussfolgerungen", ":", "Soziale", "Benachteiligung", "spielt", "fuer", "SIDS", "eine", "grosse", "Rolle", ".", "Dies", "gilt", "aber", "in", "gleicher", "Weise", "fuer", "die", "postneonatale", "Non", "-", "SIDS", "-", "Sterblichkeit", ".", "Massnahmen", "zur", "Kompensation", "sozialer", "Risikofaktoren", "sollten", "daher", "nicht", "auf", "SIDS", "beschraenkt", "bleiben", ",", "sondern", "in", "allgemeine", "Praeventionsinitiativen", "eingebunden", "werden", "." ]
[ "umlsterm" ]
Analyse, Risikofaktoren, Oesterreich, Methodik, Geburten-, Einzelgeburten, Lebensmonat, SIDS, Todesursachen, SIDS, relative Risiken, Risikofaktoren, Risikofaktoren, relative Risiko, Muettern, Frauen, SIDS, SIDS, Rolle, Risikofaktoren, SIDS
MonatsschriftKinderheilkunde.71450613.ger.abstr_task2
Sentence: Fragestellung : Analyse und Vergleich der Bedeutung sozialer Risikofaktoren fuer die SIDS- und Non-SIDS-Sterblichkeit in Oesterreich . Methodik : Die verknuepften Geburten- und Sterbedatensaetze der Jahrgaenge 1984 bis 1993 umfassen 880 601 Neugeborene ( Einzelgeburten ) , die das erste Lebensmonat ueberleben . Davon verstarben im ersten Lebensjahr 1070 Saeuglinge an SIDS , 1919 an sonstigen Todesursachen ( Non-SIDS ) . Fuer SIDS und Non-SIDS werden einfache und multivariate relative Risiken ( RR ) und 95 %-Konfidenzintervalle fuer soziale Risikofaktoren unter Kontrolle demographischer Merkmale und des Geburtsgewichts ermittelt . Ergebnisse : Soziale Risikofaktoren lassen sich sowohl fuer die postneonatale SIDS- als auch fuer die Non-SIDS-Sterblichkeit nachweisen . So betraegt das relative Risiko bei Muettern mit Pflichtschulbildung gegenueber hoeher gebildeten Frauen bei SIDS 1,45 . Nahezu gleich gross ist der Einfluss auf die Non-SIDS-Mortalitaet ( RR = 1,48 ) . Bei Gastarbeiterinnen ist das SIDS-Risiko deutlich geringer als bei Oesterreicherinnen ( RR = 0,33 ) . In Grossstaedten ist das SIDS-Risiko hoeher als in den uebrigen Gemeinden ( RR = 1,63 ) , waehrend das Non-SIDS-Risiko hier geringer ist ( RR = 0,89 ) . Schlussfolgerungen : Soziale Benachteiligung spielt fuer SIDS eine grosse Rolle . Dies gilt aber in gleicher Weise fuer die postneonatale Non-SIDS-Sterblichkeit . Massnahmen zur Kompensation sozialer Risikofaktoren sollten daher nicht auf SIDS beschraenkt bleiben , sondern in allgemeine Praeventionsinitiativen eingebunden werden . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Fragestellung : Analyse und Vergleich der Bedeutung sozialer Risikofaktoren fuer die SIDS- und Non-SIDS-Sterblichkeit in Oesterreich . Methodik : Die verknuepften Geburten- und Sterbedatensaetze der Jahrgaenge 1984 bis 1993 umfassen 880 601 Neugeborene ( Einzelgeburten ) , die das erste Lebensmonat ueberleben . Davon verstarben im ersten Lebensjahr 1070 Saeuglinge an SIDS , 1919 an sonstigen Todesursachen ( Non-SIDS ) . Fuer SIDS und Non-SIDS werden einfache und multivariate relative Risiken ( RR ) und 95 %-Konfidenzintervalle fuer soziale Risikofaktoren unter Kontrolle demographischer Merkmale und des Geburtsgewichts ermittelt . Ergebnisse : Soziale Risikofaktoren lassen sich sowohl fuer die postneonatale SIDS- als auch fuer die Non-SIDS-Sterblichkeit nachweisen . So betraegt das relative Risiko bei Muettern mit Pflichtschulbildung gegenueber hoeher gebildeten Frauen bei SIDS 1,45 . Nahezu gleich gross ist der Einfluss auf die Non-SIDS-Mortalitaet ( RR = 1,48 ) . Bei Gastarbeiterinnen ist das SIDS-Risiko deutlich geringer als bei Oesterreicherinnen ( RR = 0,33 ) . In Grossstaedten ist das SIDS-Risiko hoeher als in den uebrigen Gemeinden ( RR = 1,63 ) , waehrend das Non-SIDS-Risiko hier geringer ist ( RR = 0,89 ) . Schlussfolgerungen : Soziale Benachteiligung spielt fuer SIDS eine grosse Rolle . Dies gilt aber in gleicher Weise fuer die postneonatale Non-SIDS-Sterblichkeit . Massnahmen zur Kompensation sozialer Risikofaktoren sollten daher nicht auf SIDS beschraenkt bleiben , sondern in allgemeine Praeventionsinitiativen eingebunden werden .
[ "Fragestellung", ":", "Analyse", "und", "Vergleich", "der", "Bedeutung", "sozialer", "Risikofaktoren", "fuer", "die", "SIDS-", "und", "Non", "-", "SIDS", "-", "Sterblichkeit", "in", "Oesterreich", ".", "Methodik", ":", "Die", "verknuepften", "Geburten-", "und", "Sterbedatensaetze", "der", "Jahrgaenge", "1984", "bis", "1993", "umfassen", "880", "601", "Neugeborene", "(", "Einzelgeburten", ")", ",", "die", "das", "erste", "Lebensmonat", "ueberleben", ".", "Davon", "verstarben", "im", "ersten", "Lebensjahr", "1070", "Saeuglinge", "an", "SIDS", ",", "1919", "an", "sonstigen", "Todesursachen", "(", "Non", "-", "SIDS", ")", ".", "Fuer", "SIDS", "und", "Non", "-", "SIDS", "werden", "einfache", "und", "multivariate", "relative", "Risiken", "(", "RR", ")", "und", "95", "%", "-Konfidenzintervalle", "fuer", "soziale", "Risikofaktoren", "unter", "Kontrolle", "demographischer", "Merkmale", "und", "des", "Geburtsgewichts", "ermittelt", ".", "Ergebnisse", ":", "Soziale", "Risikofaktoren", "lassen", "sich", "sowohl", "fuer", "die", "postneonatale", "SIDS-", "als", "auch", "fuer", "die", "Non", "-", "SIDS", "-", "Sterblichkeit", "nachweisen", ".", "So", "betraegt", "das", "relative", "Risiko", "bei", "Muettern", "mit", "Pflichtschulbildung", "gegenueber", "hoeher", "gebildeten", "Frauen", "bei", "SIDS", "1,45", ".", "Nahezu", "gleich", "gross", "ist", "der", "Einfluss", "auf", "die", "Non", "-", "SIDS", "-", "Mortalitaet", "(", "RR", "=", "1,48", ")", ".", "Bei", "Gastarbeiterinnen", "ist", "das", "SIDS", "-", "Risiko", "deutlich", "geringer", "als", "bei", "Oesterreicherinnen", "(", "RR", "=", "0,33", ")", ".", "In", "Grossstaedten", "ist", "das", "SIDS", "-", "Risiko", "hoeher", "als", "in", "den", "uebrigen", "Gemeinden", "(", "RR", "=", "1,63", ")", ",", "waehrend", "das", "Non", "-", "SIDS", "-", "Risiko", "hier", "geringer", "ist", "(", "RR", "=", "0,89", ")", ".", "Schlussfolgerungen", ":", "Soziale", "Benachteiligung", "spielt", "fuer", "SIDS", "eine", "grosse", "Rolle", ".", "Dies", "gilt", "aber", "in", "gleicher", "Weise", "fuer", "die", "postneonatale", "Non", "-", "SIDS", "-", "Sterblichkeit", ".", "Massnahmen", "zur", "Kompensation", "sozialer", "Risikofaktoren", "sollten", "daher", "nicht", "auf", "SIDS", "beschraenkt", "bleiben", ",", "sondern", "in", "allgemeine", "Praeventionsinitiativen", "eingebunden", "werden", "." ]
[ "umlsterm" ]
Uncoupling protein-2 is a gene, insulin is a gene
2_task0
Sentence: Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: gene
[ "B-gene", "I-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O" ]
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.
[ "Uncoupling", "protein-2", " ", "polymorphisms", "in", "type", "2", "diabetes", ",", "obesity", ",", "and", " ", "insulin", " ", "secretion", "." ]
[ "gene", "variant" ]
Uncoupling protein-2 is a gene, insulin is a gene
2_task1
Sentence: Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Instructions: please typing these entity words according to sentence: Uncoupling protein-2, insulin Options: gene
[ "B-gene", "I-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O" ]
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.
[ "Uncoupling", "protein-2", " ", "polymorphisms", "in", "type", "2", "diabetes", ",", "obesity", ",", "and", " ", "insulin", " ", "secretion", "." ]
[ "gene", "variant" ]
Uncoupling protein-2, insulin
2_task2
Sentence: Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Instructions: please extract entity words from the input sentence
[ "B-gene", "I-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O" ]
Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.
[ "Uncoupling", "protein-2", " ", "polymorphisms", "in", "type", "2", "diabetes", ",", "obesity", ",", "and", " ", "insulin", " ", "secretion", "." ]
[ "gene", "variant" ]
beta - catenin is a Gene_or_gene_product, Braf is a Gene_or_gene_product, Pten is a Gene_or_gene_product, melanomas is a Cancer, Malignant melanoma is a Cancer, Wnt is a Gene_or_gene_product, melanoma is a Cancer, beta - catenin is a Gene_or_gene_product, mouse is a Organism, melanoma is a Cancer, melanocyte is a Cell, Pten is a Gene_or_gene_product, beta - catenin is a Gene_or_gene_product, melanoma is a Cancer, lymph nodes is a Multi-tissue_structure, lungs is a Organ, beta - catenin is a Gene_or_gene_product, tumor is a Cancer, MAPK is a Gene_or_gene_product, Erk is a Gene_or_gene_product, PI3K is a Gene_or_gene_product, Akt is a Gene_or_gene_product, tumors is a Cancer, beta - catenin is a Gene_or_gene_product, human is a Organism, melanomas is a Cancer, Wnt is a Gene_or_gene_product, melanoma is a Cancer
83_task0
Sentence: beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to the lymph nodes and lungs. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas. Together these findings establish Wnt signaling as a metastasis regulator in melanoma. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene_or_gene_product, Organ, Organism, Cancer, Multi-tissue_structure, Cell
[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cancer", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "B-Organism", "O", "O", "B-Cancer", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Cancer", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Cancer", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism", "B-Cancer", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O" ]
beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to the lymph nodes and lungs. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas. Together these findings establish Wnt signaling as a metastasis regulator in melanoma.
[ "beta", "-", "catenin", "signaling", "controls", "metastasis", "in", "Braf", "-", "activated", "Pten", "-", "deficient", "melanomas", ".", "\n", "Malignant", "melanoma", "is", "characterized", "by", "frequent", "metastasis", ",", "however", ",", "specific", "changes", "that", "regulate", "this", "process", "have", "not", "been", "clearly", "delineated", ".", "Although", "it", "is", "well", "known", "that", "Wnt", "signaling", "is", "frequently", "dysregulated", "in", "melanoma", ",", "the", "functional", "implications", "of", "this", "observation", "are", "unclear", ".", "By", "modulating", "beta", "-", "catenin", "levels", "in", "a", "mouse", "model", "of", "melanoma", "that", "is", "based", "on", "melanocyte", "-", "specific", "Pten", "loss", "and", "Braf(V600E", ")", "mutation", ",", "we", "demonstrate", "that", "beta", "-", "catenin", "is", "a", "central", "mediator", "of", "melanoma", "metastasis", "to", "the", "lymph", "nodes", "and", "lungs", ".", "In", "addition", "to", "altering", "metastasis", ",", "beta", "-", "catenin", "levels", "control", "tumor", "differentiation", "and", "regulate", "both", "MAPK", "/", "Erk", "and", "PI3K", "/", "Akt", "signaling", ".", "Highly", "metastatic", "tumors", "with", "beta", "-", "catenin", "stabilization", "are", "very", "similar", "to", "a", "subset", "of", "human", "melanomas", ".", "Together", "these", "findings", "establish", "Wnt", "signaling", "as", "a", "metastasis", "regulator", "in", "melanoma", ".", "\n" ]
[ "Cancer", "Gene_or_gene_product", "Multi-tissue_structure", "Cell", "Organism", "Amino_acid", "Organ" ]
beta - catenin is a Gene_or_gene_product, Braf is a Gene_or_gene_product, Pten is a Gene_or_gene_product, melanomas is a Cancer, Malignant melanoma is a Cancer, Wnt is a Gene_or_gene_product, melanoma is a Cancer, beta - catenin is a Gene_or_gene_product, mouse is a Organism, melanoma is a Cancer, melanocyte is a Cell, Pten is a Gene_or_gene_product, beta - catenin is a Gene_or_gene_product, melanoma is a Cancer, lymph nodes is a Multi-tissue_structure, lungs is a Organ, beta - catenin is a Gene_or_gene_product, tumor is a Cancer, MAPK is a Gene_or_gene_product, Erk is a Gene_or_gene_product, PI3K is a Gene_or_gene_product, Akt is a Gene_or_gene_product, tumors is a Cancer, beta - catenin is a Gene_or_gene_product, human is a Organism, melanomas is a Cancer, Wnt is a Gene_or_gene_product, melanoma is a Cancer
83_task1
Sentence: beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to the lymph nodes and lungs. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas. Together these findings establish Wnt signaling as a metastasis regulator in melanoma. Instructions: please typing these entity words according to sentence: beta - catenin, Braf, Pten, melanomas, Malignant melanoma, Wnt, melanoma, beta - catenin, mouse, melanoma, melanocyte, Pten, beta - catenin, melanoma, lymph nodes, lungs, beta - catenin, tumor, MAPK, Erk, PI3K, Akt, tumors, beta - catenin, human, melanomas, Wnt, melanoma Options: Gene_or_gene_product, Organ, Organism, Cancer, Multi-tissue_structure, Cell
[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cancer", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "B-Organism", "O", "O", "B-Cancer", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Cancer", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Cancer", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism", "B-Cancer", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O" ]
beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to the lymph nodes and lungs. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas. Together these findings establish Wnt signaling as a metastasis regulator in melanoma.
[ "beta", "-", "catenin", "signaling", "controls", "metastasis", "in", "Braf", "-", "activated", "Pten", "-", "deficient", "melanomas", ".", "\n", "Malignant", "melanoma", "is", "characterized", "by", "frequent", "metastasis", ",", "however", ",", "specific", "changes", "that", "regulate", "this", "process", "have", "not", "been", "clearly", "delineated", ".", "Although", "it", "is", "well", "known", "that", "Wnt", "signaling", "is", "frequently", "dysregulated", "in", "melanoma", ",", "the", "functional", "implications", "of", "this", "observation", "are", "unclear", ".", "By", "modulating", "beta", "-", "catenin", "levels", "in", "a", "mouse", "model", "of", "melanoma", "that", "is", "based", "on", "melanocyte", "-", "specific", "Pten", "loss", "and", "Braf(V600E", ")", "mutation", ",", "we", "demonstrate", "that", "beta", "-", "catenin", "is", "a", "central", "mediator", "of", "melanoma", "metastasis", "to", "the", "lymph", "nodes", "and", "lungs", ".", "In", "addition", "to", "altering", "metastasis", ",", "beta", "-", "catenin", "levels", "control", "tumor", "differentiation", "and", "regulate", "both", "MAPK", "/", "Erk", "and", "PI3K", "/", "Akt", "signaling", ".", "Highly", "metastatic", "tumors", "with", "beta", "-", "catenin", "stabilization", "are", "very", "similar", "to", "a", "subset", "of", "human", "melanomas", ".", "Together", "these", "findings", "establish", "Wnt", "signaling", "as", "a", "metastasis", "regulator", "in", "melanoma", ".", "\n" ]
[ "Cancer", "Gene_or_gene_product", "Multi-tissue_structure", "Cell", "Organism", "Amino_acid", "Organ" ]
beta - catenin, Braf, Pten, melanomas, Malignant melanoma, Wnt, melanoma, beta - catenin, mouse, melanoma, melanocyte, Pten, beta - catenin, melanoma, lymph nodes, lungs, beta - catenin, tumor, MAPK, Erk, PI3K, Akt, tumors, beta - catenin, human, melanomas, Wnt, melanoma
83_task2
Sentence: beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to the lymph nodes and lungs. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas. Together these findings establish Wnt signaling as a metastasis regulator in melanoma. Instructions: please extract entity words from the input sentence
[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Cancer", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "B-Organism", "O", "O", "B-Cancer", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "B-Multi-tissue_structure", "I-Multi-tissue_structure", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "B-Cancer", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Cancer", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organism", "B-Cancer", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O" ]
beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to the lymph nodes and lungs. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas. Together these findings establish Wnt signaling as a metastasis regulator in melanoma.
[ "beta", "-", "catenin", "signaling", "controls", "metastasis", "in", "Braf", "-", "activated", "Pten", "-", "deficient", "melanomas", ".", "\n", "Malignant", "melanoma", "is", "characterized", "by", "frequent", "metastasis", ",", "however", ",", "specific", "changes", "that", "regulate", "this", "process", "have", "not", "been", "clearly", "delineated", ".", "Although", "it", "is", "well", "known", "that", "Wnt", "signaling", "is", "frequently", "dysregulated", "in", "melanoma", ",", "the", "functional", "implications", "of", "this", "observation", "are", "unclear", ".", "By", "modulating", "beta", "-", "catenin", "levels", "in", "a", "mouse", "model", "of", "melanoma", "that", "is", "based", "on", "melanocyte", "-", "specific", "Pten", "loss", "and", "Braf(V600E", ")", "mutation", ",", "we", "demonstrate", "that", "beta", "-", "catenin", "is", "a", "central", "mediator", "of", "melanoma", "metastasis", "to", "the", "lymph", "nodes", "and", "lungs", ".", "In", "addition", "to", "altering", "metastasis", ",", "beta", "-", "catenin", "levels", "control", "tumor", "differentiation", "and", "regulate", "both", "MAPK", "/", "Erk", "and", "PI3K", "/", "Akt", "signaling", ".", "Highly", "metastatic", "tumors", "with", "beta", "-", "catenin", "stabilization", "are", "very", "similar", "to", "a", "subset", "of", "human", "melanomas", ".", "Together", "these", "findings", "establish", "Wnt", "signaling", "as", "a", "metastasis", "regulator", "in", "melanoma", ".", "\n" ]
[ "Cancer", "Gene_or_gene_product", "Multi-tissue_structure", "Cell", "Organism", "Amino_acid", "Organ" ]
hydrogen cyanide ( HCN ) and ammonia ( NH₃ ) emitted is a Phenotype, Pseudomonas aeruginosa is a Microorganism, hydrogen cyanide ( HCN ) production is a Phenotype, Pseudomonas aeruginosa is a Microorganism, P. aeruginosa is a Microorganism, production of ammonia ( NH3 ) is a Phenotype, clinical is a Habitat, patients with CF is a Habitat, pathogens is a Phenotype, lungs is a Habitat, airways of CF patients is a Habitat, Hydrogen cyanide production is a Phenotype, P. aeruginosa is a Microorganism, P. aeruginosa is a Microorganism, produced HCN is a Phenotype, HCN production is a Phenotype, Burkholderia cepacia is a Microorganism, produced HCN is a Phenotype, pathogens is a Phenotype, Aspergillus fumigatus is a Microorganism, Stenotrophomonas maltophilia is a Microorganism, Mycobacterium abscessus is a Microorganism, HCN production is a Phenotype
46_task0
Sentence: Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH₃) emitted by Pseudomonas aeruginosa. We present the real-time monitoring of hydrogen cyanide (HCN) production from Pseudomonas aeruginosa (P. aeruginosa) strains in vitro, using laser-based photoacoustic spectroscopy. Simultaneously, the production of ammonia (NH3) was measured, and the influence of different factors (e.g. the medium, temperature and antibiotics treatment) was assessed. Both reference strains and clinical isolates of patients with CF were studied, and compared to other pathogens commonly present in lungs/airways of CF patients. Hydrogen cyanide production starts to rise as soon as P. aeruginosa bacteria reach the stationary phase ((9.0-9.5) × 10(9) colony forming units, CFUs), up to concentrations of 14.5 microliters per hour (µl h(-1)). Different strains of P. aeruginosa produced HCN to varying degrees, and addition of tobramycin strongly reduced HCN production within 2 h from application. Burkholderia cepacia also produced HCN (up to 0.35µl h(-1) in 9.0  ×  10(9) CFU) while other pathogens (Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus) did not produce detectable levels. Our study reveals for the first time a broad overview of the dynamics of the HCN production in vitro. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Microorganism, Phenotype, Habitat
[ "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Habitat", "O", "O", "B-Habitat", "I-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "O", "B-Habitat", "O", "B-Habitat", "I-Habitat", "I-Habitat", "I-Habitat", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O" ]
Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH₃) emitted by Pseudomonas aeruginosa. We present the real-time monitoring of hydrogen cyanide (HCN) production from Pseudomonas aeruginosa (P. aeruginosa) strains in vitro, using laser-based photoacoustic spectroscopy. Simultaneously, the production of ammonia (NH3) was measured, and the influence of different factors (e.g. the medium, temperature and antibiotics treatment) was assessed. Both reference strains and clinical isolates of patients with CF were studied, and compared to other pathogens commonly present in lungs/airways of CF patients. Hydrogen cyanide production starts to rise as soon as P. aeruginosa bacteria reach the stationary phase ((9.0-9.5) × 10(9) colony forming units, CFUs), up to concentrations of 14.5 microliters per hour (µl h(-1)). Different strains of P. aeruginosa produced HCN to varying degrees, and addition of tobramycin strongly reduced HCN production within 2 h from application. Burkholderia cepacia also produced HCN (up to 0.35µl h(-1) in 9.0  ×  10(9) CFU) while other pathogens (Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus) did not produce detectable levels. Our study reveals for the first time a broad overview of the dynamics of the HCN production in vitro.
[ "Real", "-", "time", "monitoring", "of", "hydrogen", "cyanide", "(", "HCN", ")", "and", "ammonia", "(", "NH₃", ")", "emitted", "by", "Pseudomonas", "aeruginosa", ".", "We", "present", "the", "real", "-", "time", "monitoring", "of", "hydrogen", "cyanide", "(", "HCN", ")", "production", "from", "Pseudomonas", "aeruginosa", "(", "P.", "aeruginosa", ")", "strains", "in", "vitro", ",", "using", "laser", "-", "based", "photoacoustic", "spectroscopy", ".", "Simultaneously", ",", "the", "production", "of", "ammonia", "(", "NH3", ")", "was", "measured", ",", "and", "the", "influence", "of", "different", "factors", "(", "e.g", ".", "the", "medium", ",", "temperature", "and", "antibiotics", "treatment", ")", "was", "assessed", ".", "Both", "reference", "strains", "and", "clinical", "isolates", "of", "patients", "with", "CF", "were", "studied", ",", "and", "compared", "to", "other", "pathogens", "commonly", "present", "in", "lungs", "/", "airways", "of", "CF", "patients", ".", "Hydrogen", "cyanide", "production", "starts", "to", "rise", "as", "soon", "as", "P.", "aeruginosa", "bacteria", "reach", "the", "stationary", "phase", "(", "(", "9.0", "-", "9.5", ")", "×", "10(9", ")", "colony", "forming", "units", ",", "CFUs", ")", ",", "up", "to", "concentrations", "of", "14.5", "microliters", "per", "hour", "(", "µl", " ", "h(-1", ")", ")", ".", "Different", "strains", "of", "P.", "aeruginosa", "produced", "HCN", "to", "varying", "degrees", ",", "and", "addition", "of", "tobramycin", "strongly", "reduced", "HCN", "production", "within", "2", " ", "h", "from", "application", ".", "Burkholderia", "cepacia", "also", "produced", "HCN", "(", "up", "to", "0.35µl", " ", "h(-1", ")", "in", "9.0", "  ", "×", " ", "10(9", ")", " ", "CFU", ")", "while", "other", "pathogens", "(", "Aspergillus", "fumigatus", ",", "Stenotrophomonas", "maltophilia", ",", "Mycobacterium", "abscessus", ")", "did", "not", "produce", "detectable", "levels", ".", "Our", "study", "reveals", "for", "the", "first", "time", "a", "broad", "overview", "of", "the", "dynamics", "of", "the", "HCN", "production", "in", "vitro", ".", " " ]
[ "Phenotype", "Microorganism", "Habitat" ]
hydrogen cyanide ( HCN ) and ammonia ( NH₃ ) emitted is a Phenotype, Pseudomonas aeruginosa is a Microorganism, hydrogen cyanide ( HCN ) production is a Phenotype, Pseudomonas aeruginosa is a Microorganism, P. aeruginosa is a Microorganism, production of ammonia ( NH3 ) is a Phenotype, clinical is a Habitat, patients with CF is a Habitat, pathogens is a Phenotype, lungs is a Habitat, airways of CF patients is a Habitat, Hydrogen cyanide production is a Phenotype, P. aeruginosa is a Microorganism, P. aeruginosa is a Microorganism, produced HCN is a Phenotype, HCN production is a Phenotype, Burkholderia cepacia is a Microorganism, produced HCN is a Phenotype, pathogens is a Phenotype, Aspergillus fumigatus is a Microorganism, Stenotrophomonas maltophilia is a Microorganism, Mycobacterium abscessus is a Microorganism, HCN production is a Phenotype
46_task1
Sentence: Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH₃) emitted by Pseudomonas aeruginosa. We present the real-time monitoring of hydrogen cyanide (HCN) production from Pseudomonas aeruginosa (P. aeruginosa) strains in vitro, using laser-based photoacoustic spectroscopy. Simultaneously, the production of ammonia (NH3) was measured, and the influence of different factors (e.g. the medium, temperature and antibiotics treatment) was assessed. Both reference strains and clinical isolates of patients with CF were studied, and compared to other pathogens commonly present in lungs/airways of CF patients. Hydrogen cyanide production starts to rise as soon as P. aeruginosa bacteria reach the stationary phase ((9.0-9.5) × 10(9) colony forming units, CFUs), up to concentrations of 14.5 microliters per hour (µl h(-1)). Different strains of P. aeruginosa produced HCN to varying degrees, and addition of tobramycin strongly reduced HCN production within 2 h from application. Burkholderia cepacia also produced HCN (up to 0.35µl h(-1) in 9.0  ×  10(9) CFU) while other pathogens (Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus) did not produce detectable levels. Our study reveals for the first time a broad overview of the dynamics of the HCN production in vitro. Instructions: please typing these entity words according to sentence: hydrogen cyanide ( HCN ) and ammonia ( NH₃ ) emitted, Pseudomonas aeruginosa, hydrogen cyanide ( HCN ) production, Pseudomonas aeruginosa, P. aeruginosa, production of ammonia ( NH3 ), clinical, patients with CF, pathogens, lungs, airways of CF patients, Hydrogen cyanide production, P. aeruginosa, P. aeruginosa, produced HCN, HCN production, Burkholderia cepacia, produced HCN, pathogens, Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus, HCN production Options: Microorganism, Phenotype, Habitat
[ "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Habitat", "O", "O", "B-Habitat", "I-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "O", "B-Habitat", "O", "B-Habitat", "I-Habitat", "I-Habitat", "I-Habitat", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O" ]
Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH₃) emitted by Pseudomonas aeruginosa. We present the real-time monitoring of hydrogen cyanide (HCN) production from Pseudomonas aeruginosa (P. aeruginosa) strains in vitro, using laser-based photoacoustic spectroscopy. Simultaneously, the production of ammonia (NH3) was measured, and the influence of different factors (e.g. the medium, temperature and antibiotics treatment) was assessed. Both reference strains and clinical isolates of patients with CF were studied, and compared to other pathogens commonly present in lungs/airways of CF patients. Hydrogen cyanide production starts to rise as soon as P. aeruginosa bacteria reach the stationary phase ((9.0-9.5) × 10(9) colony forming units, CFUs), up to concentrations of 14.5 microliters per hour (µl h(-1)). Different strains of P. aeruginosa produced HCN to varying degrees, and addition of tobramycin strongly reduced HCN production within 2 h from application. Burkholderia cepacia also produced HCN (up to 0.35µl h(-1) in 9.0  ×  10(9) CFU) while other pathogens (Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus) did not produce detectable levels. Our study reveals for the first time a broad overview of the dynamics of the HCN production in vitro.
[ "Real", "-", "time", "monitoring", "of", "hydrogen", "cyanide", "(", "HCN", ")", "and", "ammonia", "(", "NH₃", ")", "emitted", "by", "Pseudomonas", "aeruginosa", ".", "We", "present", "the", "real", "-", "time", "monitoring", "of", "hydrogen", "cyanide", "(", "HCN", ")", "production", "from", "Pseudomonas", "aeruginosa", "(", "P.", "aeruginosa", ")", "strains", "in", "vitro", ",", "using", "laser", "-", "based", "photoacoustic", "spectroscopy", ".", "Simultaneously", ",", "the", "production", "of", "ammonia", "(", "NH3", ")", "was", "measured", ",", "and", "the", "influence", "of", "different", "factors", "(", "e.g", ".", "the", "medium", ",", "temperature", "and", "antibiotics", "treatment", ")", "was", "assessed", ".", "Both", "reference", "strains", "and", "clinical", "isolates", "of", "patients", "with", "CF", "were", "studied", ",", "and", "compared", "to", "other", "pathogens", "commonly", "present", "in", "lungs", "/", "airways", "of", "CF", "patients", ".", "Hydrogen", "cyanide", "production", "starts", "to", "rise", "as", "soon", "as", "P.", "aeruginosa", "bacteria", "reach", "the", "stationary", "phase", "(", "(", "9.0", "-", "9.5", ")", "×", "10(9", ")", "colony", "forming", "units", ",", "CFUs", ")", ",", "up", "to", "concentrations", "of", "14.5", "microliters", "per", "hour", "(", "µl", " ", "h(-1", ")", ")", ".", "Different", "strains", "of", "P.", "aeruginosa", "produced", "HCN", "to", "varying", "degrees", ",", "and", "addition", "of", "tobramycin", "strongly", "reduced", "HCN", "production", "within", "2", " ", "h", "from", "application", ".", "Burkholderia", "cepacia", "also", "produced", "HCN", "(", "up", "to", "0.35µl", " ", "h(-1", ")", "in", "9.0", "  ", "×", " ", "10(9", ")", " ", "CFU", ")", "while", "other", "pathogens", "(", "Aspergillus", "fumigatus", ",", "Stenotrophomonas", "maltophilia", ",", "Mycobacterium", "abscessus", ")", "did", "not", "produce", "detectable", "levels", ".", "Our", "study", "reveals", "for", "the", "first", "time", "a", "broad", "overview", "of", "the", "dynamics", "of", "the", "HCN", "production", "in", "vitro", ".", " " ]
[ "Phenotype", "Microorganism", "Habitat" ]
hydrogen cyanide ( HCN ) and ammonia ( NH₃ ) emitted, Pseudomonas aeruginosa, hydrogen cyanide ( HCN ) production, Pseudomonas aeruginosa, P. aeruginosa, production of ammonia ( NH3 ), clinical, patients with CF, pathogens, lungs, airways of CF patients, Hydrogen cyanide production, P. aeruginosa, P. aeruginosa, produced HCN, HCN production, Burkholderia cepacia, produced HCN, pathogens, Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus, HCN production
46_task2
Sentence: Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH₃) emitted by Pseudomonas aeruginosa. We present the real-time monitoring of hydrogen cyanide (HCN) production from Pseudomonas aeruginosa (P. aeruginosa) strains in vitro, using laser-based photoacoustic spectroscopy. Simultaneously, the production of ammonia (NH3) was measured, and the influence of different factors (e.g. the medium, temperature and antibiotics treatment) was assessed. Both reference strains and clinical isolates of patients with CF were studied, and compared to other pathogens commonly present in lungs/airways of CF patients. Hydrogen cyanide production starts to rise as soon as P. aeruginosa bacteria reach the stationary phase ((9.0-9.5) × 10(9) colony forming units, CFUs), up to concentrations of 14.5 microliters per hour (µl h(-1)). Different strains of P. aeruginosa produced HCN to varying degrees, and addition of tobramycin strongly reduced HCN production within 2 h from application. Burkholderia cepacia also produced HCN (up to 0.35µl h(-1) in 9.0  ×  10(9) CFU) while other pathogens (Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus) did not produce detectable levels. Our study reveals for the first time a broad overview of the dynamics of the HCN production in vitro. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Habitat", "O", "O", "B-Habitat", "I-Habitat", "I-Habitat", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "O", "O", "B-Habitat", "O", "B-Habitat", "I-Habitat", "I-Habitat", "I-Habitat", "O", "B-Phenotype", "I-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "B-Microorganism", "I-Microorganism", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "B-Microorganism", "I-Microorganism", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Phenotype", "I-Phenotype", "O", "O", "O", "O" ]
Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH₃) emitted by Pseudomonas aeruginosa. We present the real-time monitoring of hydrogen cyanide (HCN) production from Pseudomonas aeruginosa (P. aeruginosa) strains in vitro, using laser-based photoacoustic spectroscopy. Simultaneously, the production of ammonia (NH3) was measured, and the influence of different factors (e.g. the medium, temperature and antibiotics treatment) was assessed. Both reference strains and clinical isolates of patients with CF were studied, and compared to other pathogens commonly present in lungs/airways of CF patients. Hydrogen cyanide production starts to rise as soon as P. aeruginosa bacteria reach the stationary phase ((9.0-9.5) × 10(9) colony forming units, CFUs), up to concentrations of 14.5 microliters per hour (µl h(-1)). Different strains of P. aeruginosa produced HCN to varying degrees, and addition of tobramycin strongly reduced HCN production within 2 h from application. Burkholderia cepacia also produced HCN (up to 0.35µl h(-1) in 9.0  ×  10(9) CFU) while other pathogens (Aspergillus fumigatus, Stenotrophomonas maltophilia, Mycobacterium abscessus) did not produce detectable levels. Our study reveals for the first time a broad overview of the dynamics of the HCN production in vitro.
[ "Real", "-", "time", "monitoring", "of", "hydrogen", "cyanide", "(", "HCN", ")", "and", "ammonia", "(", "NH₃", ")", "emitted", "by", "Pseudomonas", "aeruginosa", ".", "We", "present", "the", "real", "-", "time", "monitoring", "of", "hydrogen", "cyanide", "(", "HCN", ")", "production", "from", "Pseudomonas", "aeruginosa", "(", "P.", "aeruginosa", ")", "strains", "in", "vitro", ",", "using", "laser", "-", "based", "photoacoustic", "spectroscopy", ".", "Simultaneously", ",", "the", "production", "of", "ammonia", "(", "NH3", ")", "was", "measured", ",", "and", "the", "influence", "of", "different", "factors", "(", "e.g", ".", "the", "medium", ",", "temperature", "and", "antibiotics", "treatment", ")", "was", "assessed", ".", "Both", "reference", "strains", "and", "clinical", "isolates", "of", "patients", "with", "CF", "were", "studied", ",", "and", "compared", "to", "other", "pathogens", "commonly", "present", "in", "lungs", "/", "airways", "of", "CF", "patients", ".", "Hydrogen", "cyanide", "production", "starts", "to", "rise", "as", "soon", "as", "P.", "aeruginosa", "bacteria", "reach", "the", "stationary", "phase", "(", "(", "9.0", "-", "9.5", ")", "×", "10(9", ")", "colony", "forming", "units", ",", "CFUs", ")", ",", "up", "to", "concentrations", "of", "14.5", "microliters", "per", "hour", "(", "µl", " ", "h(-1", ")", ")", ".", "Different", "strains", "of", "P.", "aeruginosa", "produced", "HCN", "to", "varying", "degrees", ",", "and", "addition", "of", "tobramycin", "strongly", "reduced", "HCN", "production", "within", "2", " ", "h", "from", "application", ".", "Burkholderia", "cepacia", "also", "produced", "HCN", "(", "up", "to", "0.35µl", " ", "h(-1", ")", "in", "9.0", "  ", "×", " ", "10(9", ")", " ", "CFU", ")", "while", "other", "pathogens", "(", "Aspergillus", "fumigatus", ",", "Stenotrophomonas", "maltophilia", ",", "Mycobacterium", "abscessus", ")", "did", "not", "produce", "detectable", "levels", ".", "Our", "study", "reveals", "for", "the", "first", "time", "a", "broad", "overview", "of", "the", "dynamics", "of", "the", "HCN", "production", "in", "vitro", ".", " " ]
[ "Phenotype", "Microorganism", "Habitat" ]
CO2 is an umlsterm, laser is an umlsterm, blepharoplasty is an umlsterm, time is an umlsterm, ultrapulse is an umlsterm, CO2 is an umlsterm, laser is an umlsterm, instrument is an umlsterm, ophthalmology is an umlsterm
DerOpthalmologe.00970194.eng.abstr_task0
Sentence: Background : Baker et al. used a CO2 laser for blepharoplasty for the first time . The ultrapulse CO2 laser provides a sophisticated instrument that makes more application alternatives possible in ophthalmology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Background : Baker et al. used a CO2 laser for blepharoplasty for the first time . The ultrapulse CO2 laser provides a sophisticated instrument that makes more application alternatives possible in ophthalmology .
[ "Background", ":", "Baker", "et", "al", ".", "used", "a", "CO2", "laser", "for", "blepharoplasty", "for", "the", "first", "time", ".", "The", "ultrapulse", "CO2", "laser", "provides", "a", "sophisticated", "instrument", "that", "makes", "more", "application", "alternatives", "possible", "in", "ophthalmology", "." ]
[ "umlsterm" ]
CO2 is an umlsterm, laser is an umlsterm, blepharoplasty is an umlsterm, time is an umlsterm, ultrapulse is an umlsterm, CO2 is an umlsterm, laser is an umlsterm, instrument is an umlsterm, ophthalmology is an umlsterm
DerOpthalmologe.00970194.eng.abstr_task1
Sentence: Background : Baker et al. used a CO2 laser for blepharoplasty for the first time . The ultrapulse CO2 laser provides a sophisticated instrument that makes more application alternatives possible in ophthalmology . Instructions: please typing these entity words according to sentence: CO2, laser, blepharoplasty, time, ultrapulse, CO2, laser, instrument, ophthalmology Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Background : Baker et al. used a CO2 laser for blepharoplasty for the first time . The ultrapulse CO2 laser provides a sophisticated instrument that makes more application alternatives possible in ophthalmology .
[ "Background", ":", "Baker", "et", "al", ".", "used", "a", "CO2", "laser", "for", "blepharoplasty", "for", "the", "first", "time", ".", "The", "ultrapulse", "CO2", "laser", "provides", "a", "sophisticated", "instrument", "that", "makes", "more", "application", "alternatives", "possible", "in", "ophthalmology", "." ]
[ "umlsterm" ]
CO2, laser, blepharoplasty, time, ultrapulse, CO2, laser, instrument, ophthalmology
DerOpthalmologe.00970194.eng.abstr_task2
Sentence: Background : Baker et al. used a CO2 laser for blepharoplasty for the first time . The ultrapulse CO2 laser provides a sophisticated instrument that makes more application alternatives possible in ophthalmology . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Background : Baker et al. used a CO2 laser for blepharoplasty for the first time . The ultrapulse CO2 laser provides a sophisticated instrument that makes more application alternatives possible in ophthalmology .
[ "Background", ":", "Baker", "et", "al", ".", "used", "a", "CO2", "laser", "for", "blepharoplasty", "for", "the", "first", "time", ".", "The", "ultrapulse", "CO2", "laser", "provides", "a", "sophisticated", "instrument", "that", "makes", "more", "application", "alternatives", "possible", "in", "ophthalmology", "." ]
[ "umlsterm" ]
percutaneous coronary intervention is a Procedure, drug - eluting stent is a Device
NCT02859480_inc_task0
Sentence: Patients underwent percutaneous coronary intervention with drug-eluting stent; Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Device, Procedure
[ "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "I-Device", "I-Device", "I-Device", "O", "O" ]
Patients underwent percutaneous coronary intervention with drug-eluting stent;
[ "Patients", "underwent", "percutaneous", "coronary", "intervention", "with", "drug", "-", "eluting", "stent", ";", "\n" ]
[ "Procedure", "Device" ]
percutaneous coronary intervention is a Procedure, drug - eluting stent is a Device
NCT02859480_inc_task1
Sentence: Patients underwent percutaneous coronary intervention with drug-eluting stent; Instructions: please typing these entity words according to sentence: percutaneous coronary intervention, drug - eluting stent Options: Device, Procedure
[ "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "I-Device", "I-Device", "I-Device", "O", "O" ]
Patients underwent percutaneous coronary intervention with drug-eluting stent;
[ "Patients", "underwent", "percutaneous", "coronary", "intervention", "with", "drug", "-", "eluting", "stent", ";", "\n" ]
[ "Procedure", "Device" ]
percutaneous coronary intervention, drug - eluting stent
NCT02859480_inc_task2
Sentence: Patients underwent percutaneous coronary intervention with drug-eluting stent; Instructions: please extract entity words from the input sentence
[ "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "I-Device", "I-Device", "I-Device", "O", "O" ]
Patients underwent percutaneous coronary intervention with drug-eluting stent;
[ "Patients", "underwent", "percutaneous", "coronary", "intervention", "with", "drug", "-", "eluting", "stent", ";", "\n" ]
[ "Procedure", "Device" ]