Datasets:

lhallee

/

exp_new_unprocessed

like 0

A0A2I2UGY1

MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKSSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRDRYTKIVEIPFNSTNKYQLSIHKNPNTSEPRHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNFPVENLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPTHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKEHYHSYTRIFFFRKTSKMYFH

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis. {ECO:0000256|ARBA:ARBA00044487}.

CATALYTIC ACTIVITY: Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.13; Evidence={ECO:0000256|ARBA:ARBA00035887};

ATP-binding;Cell membrane;Ion transport;Membrane;Metal-binding;Nucleotide-binding;Potassium;Potassium transport;Reference proteome;Sodium;Sodium transport;Sodium/potassium transport;Translocase;Transmembrane;Transmembrane helix;Transport

cellular response to steroid hormone stimulus [GO:0071383]; heart contraction [GO:0060047]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; membrane repolarization [GO:0086009]; negative regulation of glucocorticoid biosynthetic process [GO:0031947]; negative regulation of heart contraction [GO:0045822]; osmosensory signaling pathway [GO:0007231]; positive regulation of heart contraction [GO:0045823]; positive regulation of striated muscle contraction [GO:0045989]; potassium ion import across plasma membrane [GO:1990573]; proton transmembrane transport [GO:1902600]; regulation of blood pressure [GO:0008217]; regulation of the force of heart contraction [GO:0002026]; response to glycoside [GO:1903416]; response to xenobiotic stimulus [GO:0009410]; sodium ion export across plasma membrane [GO:0036376]

apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]; melanosome [GO:0042470]; organelle membrane [GO:0031090]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; sperm flagellum [GO:0036126]; T-tubule [GO:0030315]

ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; P-type sodium:potassium-exchanging transporter activity [GO:0005391]; phosphatase activity [GO:0016791]; protein-folding chaperone binding [GO:0051087]; steroid hormone binding [GO:1990239]; transmembrane transporter binding [GO:0044325]

SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004554}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004415}. Cell membrane {ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Lateral cell membrane {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00034693}. Melanosome {ECO:0000256|ARBA:ARBA00004223}.

IPR006068;IPR004014;IPR023299;IPR018303;IPR023298;IPR008250;IPR036412;IPR023214;IPR005775;IPR001757;IPR044492;

3.40.1110.10;2.70.150.10;1.20.1110.10;3.40.50.1000;

A0A2I2UHK7

MGSTFTSGRLEKTWENSRRQVLEVPMENSENSVDAKSIKNSETKIFHGSKSMDSGIYMDNSYKMDYPEMGLCIIINNKNFHESTGMPSRSGTDVDAANLRETFTNLKYEVRNKNDLTREQIVALLDSVSREDHSKRSSFICVLLSHGDEGIIYGTNGPVDLKKLTGFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTEDDIACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLRLYAHKLEFMHILTRVNRKVALEFESFSLDSAFHGKKQIPCIVSMLTKELYFYH

Felis catus (Cat) (Felis silvestris catus)

3.4.22.56

CATALYTIC ACTIVITY: Reaction=Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.; EC=3.4.22.56; Evidence={ECO:0000256|ARBA:ARBA00036189};

Apoptosis;Cytoplasm;Hydrolase;Protease;Reference proteome;S-nitrosylation;Thiol protease;Zymogen

anterior neural tube closure [GO:0061713]; B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to staurosporine [GO:0072734]; DNA damage response [GO:0006974]; epithelial cell apoptotic process [GO:1904019]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; fibroblast apoptotic process [GO:0044346]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production [GO:0001818]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptosis [GO:0140639]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptosis [GO:0070269]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; T cell homeostasis [GO:0043029]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; nucleus [GO:0005634]

aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199]; cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200]; enzyme activator activity [GO:0008047]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR029030;IPR033139;IPR016129;IPR011600;IPR002138;IPR001309;IPR015917;

3.40.50.1460;

A0A2I2UHX9

MARRPRRATYRAAARGREVRLPEDGAGRRRRAPSPTSAPGGPEGRRPARAGGTRRTAPDGPRPRGRLPAPRRSAHARPRAVRGAAGAGTGTLGAAVRRRLPLLLARGSPGTRGPALCASLPQAPAGPGAAQARSRGPRAPARKSARPTVAGRCVRAACAAAWAMGRRARGRRLQQRPQGAEDGAEGGGKRREAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWDQFMEALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPQLEKFHQFLVSETESGNISRQEAVSMIPPLLLNAHPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLTIDVNGKKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLVEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSSELPGLKWMPGITQWKVMTKDGQWFSEWEAVPHGRHTQIRPTMFPPKDPERLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRPPKLQGEPREPVRSGPTDPAELESKPAGGIDDTEITERAENVENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIQKFYALDPSFPKMNLLTRTTEGKKRQLYMVSKELRNVLLNNSERVKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDPTKPDTLQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLAEKKKEGAILAPESAGGSGPPEAEEAGAEHGVEPAASPSVDAAPGPDPAEGALPR

Felis catus (Cat) (Felis silvestris catus)

2.1.1.203

CATALYTIC ACTIVITY: Reaction=a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61464, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15826, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00000377}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61465; Evidence={ECO:0000256|ARBA:ARBA00000377}; CATALYTIC ACTIVITY: Reaction=cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42940, Rhea:RHEA-COMP:10291, Rhea:RHEA-COMP:10295, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; EC=2.1.1.203; Evidence={ECO:0000256|ARBA:ARBA00001128}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42941; Evidence={ECO:0000256|ARBA:ARBA00001128}; CATALYTIC ACTIVITY: Reaction=cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42948, Rhea:RHEA-COMP:10293, Rhea:RHEA-COMP:10297, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00001405}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42949; Evidence={ECO:0000256|ARBA:ARBA00001405}; CATALYTIC ACTIVITY: Reaction=cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42952, Rhea:RHEA-COMP:10294, Rhea:RHEA-COMP:10385, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00000276}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42953; Evidence={ECO:0000256|ARBA:ARBA00000276}; CATALYTIC ACTIVITY: Reaction=cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61488, Rhea:RHEA-COMP:15838, Rhea:RHEA-COMP:15839, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00001828}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61489; Evidence={ECO:0000256|ARBA:ARBA00001828};

Acetylation;Methyltransferase;Nucleus;Phosphoprotein;Reference proteome;RNA-binding;S-adenosyl-L-methionine;Transferase;tRNA processing;tRNA-binding

hair follicle maturation [GO:0048820]; in utero embryonic development [GO:0001701]; meiotic cell cycle checkpoint signaling [GO:0033313]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA stabilization [GO:0036416]

chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]

mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]

SUBCELLULAR LOCATION: Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.

IPR049560;IPR001678;IPR023267;IPR023270;IPR029063;

3.40.50.150;

A0A2I2UI03

MRFRFGVVVPPAVAGRGPELLVVGSRPELGGWEPRGAVRLRPAGTAAGAGALALQEPGLWLGEVELAPEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYKEEGLVYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAAVCGWLQYVLGWNLRKVQYFLMAKRPAVYIDEDALARAEEDFFQKFGKVRSSVCSV

Felis catus (Cat) (Felis silvestris catus)

3.1.3.48

Carbohydrate metabolism;Hydrolase;Protein phosphatase;Reference proteome

autophagosome assembly [GO:0000045]; calcium ion transport [GO:0006816]; carbohydrate phosphorylation [GO:0046835]; dephosphorylation [GO:0016311]; glial cell proliferation [GO:0014009]; glycogen biosynthetic process [GO:0005978]; habituation [GO:0046959]; L-glutamate transmembrane transport [GO:0015813]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of macroautophagy [GO:0016239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell growth [GO:0001558]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein import into nucleus [GO:0042306]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein ubiquitination [GO:0031396]; Wnt signaling pathway [GO:0016055]

cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]

carbohydrate phosphatase activity [GO:0019203]; glycogen (starch) synthase activity [GO:0004373]; glycogen binding [GO:2001069]; protein homodimerization activity [GO:0042803]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; starch binding [GO:2001070]

IPR013784;IPR034831;IPR002044;IPR045204;IPR000340;IPR013783;IPR042942;IPR029021;IPR016130;IPR000387;IPR020422;

2.60.40.10;3.90.190.10;

A0A2I2UI65

MNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAVFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHPVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMME

Felis catus (Cat) (Felis silvestris catus)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Developmental protein;Disulfide bond;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of autophagosome assembly [GO:2000785]; regulation of blood coagulation [GO:0030193]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; urogenital system development [GO:0001655]

axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]

amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; transmembrane-ephrin receptor activity [GO:0005005]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR027936;IPR001090;IPR003961;IPR036116;IPR008979;IPR009030;IPR013783;IPR011009;IPR000719;IPR017441;IPR001660;IPR013761;IPR001245;IPR011641;IPR008266;IPR020635;IPR016257;IPR001426;

2.60.40.1770;2.60.120.260;2.60.40.10;1.10.150.50;1.10.510.10;2.10.50.10;

A0A2I2UII4

MCAAPLAAAALAAAAPRSVYSFSARPLAGGEPMSLGSLRGKVLLIENVASLGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGAQAHPLFAFLRQALPAPSDDATALMTDPKFITWSPVCRNDVAWNFEKFLVGPDGVPVRRYSRRFPTIDIEPDIEALLSQGPSCA

Felis catus (Cat) (Felis silvestris catus)

CATALYTIC ACTIVITY: Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:50708, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90680; Evidence={ECO:0000256|ARBA:ARBA00036482}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50709; Evidence={ECO:0000256|ARBA:ARBA00036482}; CATALYTIC ACTIVITY: Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9; Evidence={ECO:0000256|ARBA:ARBA00036108}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16834; Evidence={ECO:0000256|ARBA:ARBA00036108};

Oxidoreductase;Peroxidase;Reference proteome

angiogenesis involved in wound healing [GO:0060055]; arachidonic acid metabolic process [GO:0019369]; biological process involved in interaction with symbiont [GO:0051702]; blood vessel endothelial cell migration [GO:0043534]; cell redox homeostasis [GO:0045454]; endothelial cell development [GO:0001885]; epigenetic regulation of gene expression [GO:0040029]; fat cell differentiation [GO:0045444]; fibroblast proliferation [GO:0048144]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide catabolic process [GO:0042744]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipoxygenase pathway [GO:0019372]; myoblast differentiation [GO:0045445]; myoblast proliferation [GO:0051450]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neuron apoptotic process [GO:0051402]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of proteasomal protein catabolic process [GO:0061136]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to hydroperoxide [GO:0033194]; response to selenium ion [GO:0010269]; response to symbiotic bacterium [GO:0009609]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; temperature homeostasis [GO:0001659]; triglyceride metabolic process [GO:0006641]; UV protection [GO:0009650]; vasodilation [GO:0042311]

cytosol [GO:0005829]; Lewy body [GO:0097413]; mitochondrion [GO:0005739]

glutathione peroxidase activity [GO:0004602]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; SH3 domain binding [GO:0017124]

IPR000889;IPR029760;IPR036249;

3.40.30.10;

A0A2I2UIN3

MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDATSLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSPIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

ATP-binding;Kinase;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc

death-inducing signaling complex assembly [GO:0071550]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intermediate filament cytoskeleton organization [GO:0045104]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of protein-containing complex assembly [GO:0031333]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphorylation [GO:0016310]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; response to muscle stretch [GO:0035994]; Schwann cell development [GO:0014044]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; type B pancreatic cell proliferation [GO:0044342]

cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.

IPR046349;IPR020454;IPR011009;IPR002219;IPR000719;IPR017441;IPR003116;IPR008271;IPR029071;

3.30.60.20;1.10.510.10;

A0A2I2UK29

MEAGVSLKRRIKLKTESPWRCGAWSPTSNCRTGMWSWKYLLLAVLVTATLCTARPAPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

Felis catus (Cat) (Felis silvestris catus)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171, ECO:0000256|PIRNR:PIRNR000628};

ATP-binding;Cell membrane;Cytoplasmic vesicle;Disulfide bond;Glycoprotein;Immunoglobulin domain;Kinase;Membrane;Nucleotide-binding;Nucleus;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase;Ubl conjugation

angiogenesis [GO:0001525]; auditory receptor cell development [GO:0060117]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium ion homeostasis [GO:0055074]; cardiac muscle cell proliferation [GO:0060038]; cell maturation [GO:0048469]; cell projection assembly [GO:0030031]; cementum mineralization [GO:0071529]; chondrocyte differentiation [GO:0002062]; diphosphate metabolic process [GO:0071344]; embryonic limb morphogenesis [GO:0030326]; epithelial to mesenchymal transition [GO:0001837]; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; lung-associated mesenchyme development [GO:0060484]; mesenchymal cell proliferation [GO:0010463]; midbrain development [GO:0030901]; middle ear morphogenesis [GO:0042474]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection development [GO:0031175]; organ induction [GO:0001759]; outer ear morphogenesis [GO:0042473]; paraxial mesoderm development [GO:0048339]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell differentiation [GO:0045597]; positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546]; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [GO:0090080]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic cell cycle DNA replication [GO:1903465]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of neuron projection development [GO:0010976]; positive regulation of parathyroid hormone secretion [GO:2000830]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001239]; regulation of lateral mesodermal cell fate specification [GO:0048378]; regulation of phosphate transport [GO:0010966]; regulation of phosphorus metabolic process [GO:0051174]; response to sodium phosphate [GO:1904383]; sensory perception of sound [GO:0007605]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; ureteric bud development [GO:0001657]; ventricular zone neuroblast division [GO:0021847]; vitamin D3 metabolic process [GO:0070640]

cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]

ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; receptor-receptor interaction [GO:0090722]; SH2 domain binding [GO:0042169]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Vesicle {ECO:0000256|ARBA:ARBA00004373}.

IPR028174;IPR016248;IPR007110;IPR036179;IPR013783;IPR013098;IPR003599;IPR003598;IPR013151;IPR011009;IPR000719;IPR017441;IPR001245;IPR008266;IPR020635;

2.60.40.10;1.10.510.10;

A0A2I2ULD8

MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQVIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKGSRRRSSWPEQTSPVVASCQVSHLSPTTAQILYFLSLCVFI

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins. {ECO:0000256|PIRNR:PIRNR037913}.

3.5.1.98

CATALYTIC ACTIVITY: Reaction=H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]; Xref=Rhea:RHEA:69172, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:35899, ChEBI:CHEBI:137954; Evidence={ECO:0000256|ARBA:ARBA00029357}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69173; Evidence={ECO:0000256|ARBA:ARBA00029357}; CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence={ECO:0000256|ARBA:ARBA00029372}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58197; Evidence={ECO:0000256|ARBA:ARBA00029372}; CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]; Xref=Rhea:RHEA:58108, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; Evidence={ECO:0000256|ARBA:ARBA00029349}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58109; Evidence={ECO:0000256|ARBA:ARBA00029349};

Chromatin regulator;Hydrolase;Metal-binding;Nucleus;Reference proteome;Repressor;Transcription;Transcription regulation

circadian regulation of gene expression [GO:0032922]; DNA methylation-dependent heterochromatin formation [GO:0006346]; embryonic digit morphogenesis [GO:0042733]; endoderm development [GO:0007492]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; hair follicle placode formation [GO:0060789]; hippocampus development [GO:0021766]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of transcription by RNA polymerase II [GO:0045944]

cytosol [GO:0005829]; heterochromatin [GO:0000792]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; Sin3-type complex [GO:0070822]; transcription repressor complex [GO:0017053]

E-box binding [GO:0070888]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; histone decrotonylase activity [GO:0160009]; Krueppel-associated box domain binding [GO:0035851]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; transcription corepressor activity [GO:0003714]; transcription corepressor binding [GO:0001222]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037913}.

IPR000286;IPR003084;IPR023801;IPR037138;IPR023696;

3.40.800.20;

A0A2I2ULG3

MKFLVLAALLTVGAAEGGVSPRAVWQLRNMIKCTIPESDPVRDYTDYGCYCGLGGSGTPVDELDKCCQTHDHCYSRAKKLDSCKFLLDNPYTKTYSYSCSGSEITCSDENKPCEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYCKN

Felis catus (Cat) (Felis silvestris catus)

3.1.1.4

CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate; Xref=Rhea:RHEA:41223, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:72999; Evidence={ECO:0000256|ARBA:ARBA00001479}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41224; Evidence={ECO:0000256|ARBA:ARBA00001479}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003; Evidence={ECO:0000256|ARBA:ARBA00023922}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428; Evidence={ECO:0000256|ARBA:ARBA00023922}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:40815, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:73004, ChEBI:CHEBI:73008; Evidence={ECO:0000256|ARBA:ARBA00001804}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40816; Evidence={ECO:0000256|ARBA:ARBA00001804}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence={ECO:0000256|ARBA:ARBA00001855}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40920; Evidence={ECO:0000256|ARBA:ARBA00001855}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998, ChEBI:CHEBI:73001; Evidence={ECO:0000256|ARBA:ARBA00001126}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780; Evidence={ECO:0000256|ARBA:ARBA00001126}; CATALYTIC ACTIVITY: Reaction=H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:56424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:85334, ChEBI:CHEBI:85335; Evidence={ECO:0000256|ARBA:ARBA00036781}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56425; Evidence={ECO:0000256|ARBA:ARBA00036781}; CATALYTIC ACTIVITY: Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:45424, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:78097, ChEBI:CHEBI:85217; Evidence={ECO:0000256|ARBA:ARBA00001129}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45425; Evidence={ECO:0000256|ARBA:ARBA00001129}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000256|ARBA:ARBA00001604, ECO:0000256|RuleBase:RU361236};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR601211-2}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR601211-2};

Calcium;Disulfide bond;Hydrolase;Lipid metabolism;Metal-binding;Reference proteome;Secreted;Signal

antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; arachidonic acid secretion [GO:0050482]; defense response to Gram-positive bacterium [GO:0050830]; fatty acid biosynthetic process [GO:0006633]; innate immune response in mucosa [GO:0002227]; lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid metabolic process [GO:0006644]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of podocyte apoptotic process [GO:1904635]

cell surface [GO:0009986]; extracellular space [GO:0005615]

calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]; signaling receptor binding [GO:0005102]

SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU361236}.

IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;

1.20.90.10;

A0A2I2UPC3

MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSVTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1; 2.7.11.31

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]; Xref=Rhea:RHEA:23172, Rhea:RHEA-COMP:13692, Rhea:RHEA-COMP:13693, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.31; Evidence={ECO:0000256|ARBA:ARBA00023941}; CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]; Xref=Rhea:RHEA:20333, Rhea:RHEA-COMP:13722, Rhea:RHEA-COMP:13723, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036863}; CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

ATP-binding;Autophagy;Biological rhythms;Cholesterol biosynthesis;Cholesterol metabolism;Cytoplasm;Lipid biosynthesis;Lipid metabolism;Metal-binding;Nucleotide-binding;Reference proteome;Steroid biosynthesis;Steroid metabolism;Sterol biosynthesis;Sterol metabolism;Wnt signaling pathway

autophagy [GO:0006914]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to oxidative stress [GO:0034599]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol biosynthetic process [GO:0006695]; intracellular signal transduction [GO:0035556]; lipid droplet disassembly [GO:1905691]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of tubulin deacetylation [GO:1904428]; positive regulation of autophagy [GO:0010508]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; regulation of circadian rhythm [GO:0042752]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; response to muscle activity [GO:0014850]; rhythmic process [GO:0048511]; Wnt signaling pathway [GO:0016055]

axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]

[acetyl-CoA carboxylase] kinase activity [GO:0050405]; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR032270;IPR039148;IPR028375;IPR011009;IPR049020;IPR028783;IPR000719;IPR017441;IPR008271;

1.10.8.10;3.30.310.80;1.10.510.10;

A0A2I2UPF0

MAAAAAQGGGGGEPGGADGVGPGVSGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDAKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGALEAP

Felis catus (Cat) (Felis silvestris catus)

2.7.11.24

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000494}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000088, ECO:0000256|RuleBase:RU361165};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU361165};

ATP-binding;Kinase;Magnesium;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

Bergmann glial cell differentiation [GO:0060020]; BMP signaling pathway [GO:0030509]; cardiac neural crest cell development involved in heart development [GO:0061308]; cartilage development [GO:0051216]; caveolin-mediated endocytosis [GO:0072584]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to mechanical stimulus [GO:0071260]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; DNA-templated transcription [GO:0006351]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung morphogenesis [GO:0060425]; modulation of chemical synaptic transmission [GO:0050804]; myelination [GO:0042552]; negative regulation of TORC1 signaling [GO:1904262]; outer ear morphogenesis [GO:0042473]; phosphorylation [GO:0016310]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of xenophagy [GO:1904417]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; Schwann cell development [GO:0014044]; sensory perception of pain [GO:0019233]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; xenophagy [GO:0098792]

caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pseudopodium [GO:0031143]

ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]

SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004345}.

IPR011009;IPR003527;IPR008349;IPR000719;IPR017441;IPR008271;

1.10.510.10;

A0A2I2UQK0

MKQLPPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFFKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQNDTPNSPAGPLQVDLTPKIKMDVGDTLSTTEESSPPKSRVELGKIHFKKHLLHVTSRPLLTTATAVVSPPPPVVPLPAVIAESTTVDSPPSSPPPPPPPPQATTPSPAPVTEPVALPHTPIPVLMTAPVDVAVRTLKEPPVTTVPESSDVDTKQDAVSNSSEEHITQNLNEQADTPSQKEDSHIGKEEEIPDSSKSNLGSKKTGSKKKSSQSEGTFLASESDEDSVRTSSSQRSHDLKFSASIEKERDSKKSLAPLKSEDLGKSSRSKTERDDKYFSYSKLERDTRYISSRCRSERERRRSRSRSRSDRGSRTSLSYSRSERSHYYDSDRRYHRSSPYRERARYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSFSYRDLRTSSSYSKSDRDCKTESSYLEMEKRGKYSSKVERESKRTSENEAMKRCCSPPNELGFRRGSSYSKHDNSASRYKSALSKSVSKSDKFKNSFCCTELNEEIRSSHSFNLQAPCSKGSELRMISKIPEREKTGSPSPSNRLNDSPTFKKLDESLIFKSEFIGHDSHDSIKELDSLSKVKNDQLRSYCPIELNINGSPGAESDLATFCTSKTDTVLMSSDDSVTGSEVSPLVKACMLSSNGFQNINRCKEKDSDNTCMLRSKSGSPFRETEPTVSPHQDKLMSLPVTTIDYSKTVIKEPVDMAVSCCKTKDSDLYCTSNDNNPSLRHSEAEKIEPSVMKISSNSFMNVHLKSKTVICDDRNLTDQHSKFAREEYKQSVGSTSSASVNHFDDIYQPIESSGVASSLQSLPPGVKVDSLTLLQCGENASPVLDAVLKSKSTEFVKHAEKETIIEVGSDLPDSGRGFASWENRHNNGLSGKCVQEAQEEGSSIVLERRGRSEISLDEEGGRGHAHTSDDSEVVFSSCDLNLTMEDSDGITYTLKCDSSGHASEIVSTVHEDYSGSSESSSDESDSEDTDSDDSSFPRNRLQSVVVVPKNSTLPTEETSPCSSRSSQSYRHYSDHWEDERLESRRHSYEEKYDSVASKPCSQTEKFFHHKGTEKNPEISFTHPSRKQIDNHLSEIVHPQSDGVDSTSHTDVKSDFLGHPNSEETAKAKIASRQQEELPVYSSDDFEDIPNKSRQQTIFPNRPDSRLGKTELSFSSSCEISRVDGFRSSEELRNLGWEFSQQEKPTTTYQQPDSSYGACGGHKYQQSAEHYGGTRNYWQGNGYWDPRSAGRPPGTGVVYDRIQGQVPDSLTDDREEEDSWDQCAGSHFSSQSSKFFLSLQKDKGSVQAPEISSNSIKDSLAVNEKKDLSKNLEKNDMKDRGPPKKRRPELESDSESDGELQDRKKVRVAVEQGETALPPGSALVGPSCVMEDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECAPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAIPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLEHVPVEDEEELQSQQLLTQQLPESKVESEIAMEASKLPISEPEADAEIEPKEGNGTKLEETIAEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTITERGRDAVGFRDQTAAPKTPNRSRERDPDKQTQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHSQPLVGHSTEPLAAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVTVLPVPAPGPVQGQNYGVWDSNQQSVSVPQQYSPAQSQATIYYQGQTCPAVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTAIVTPGQPQPLQPPEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKTSKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE

Felis catus (Cat) (Felis silvestris catus)

2.1.1.359

CATALYTIC ACTIVITY: Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA-COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359; Evidence={ECO:0000256|ARBA:ARBA00000317};

Chromatin regulator;Chromosome;Methyltransferase;Nucleus;Reference proteome;S-adenosyl-L-methionine;Transcription;Transcription regulation;Transferase

angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; defense response to virus [GO:0051607]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; endodermal cell differentiation [GO:0035987]; forebrain development [GO:0030900]; mesoderm morphogenesis [GO:0048332]; methylation [GO:0032259]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; pericardium development [GO:0060039]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to type I interferon [GO:0034340]; stem cell development [GO:0048864]; transcription elongation by RNA polymerase II [GO:0006368]

chromosome [GO:0005694]; nucleus [GO:0005634]

alpha-tubulin binding [GO:0043014]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]

SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR006560;IPR003616;IPR001214;IPR046341;IPR044437;IPR042294;IPR013257;IPR038190;IPR035441;IPR001202;IPR036020;

2.20.70.10;1.20.930.10;2.170.270.10;1.10.1740.100;

A0A2I2USU9

MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAAACSDGHLASPGENGEVRQGQAKRLGLDEFTFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. {ECO:0000256|PIRNR:PIRNR000551}.

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000946}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569, ECO:0000256|PIRNR:PIRNR000551};

ATP-binding;Cell adhesion;Cell cycle;Cell division;Cell membrane;Cytoplasm;Cytoskeleton;Kinase;Membrane;Metal-binding;Nucleotide-binding;Nucleus;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc;Zinc-finger

cell cycle [GO:0007049]; cell division [GO:0051301]; cell-substrate adhesion [GO:0031589]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; cellular response to prostaglandin E stimulus [GO:0071380]; establishment of localization in cell [GO:0051649]; insulin secretion [GO:0030073]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; locomotory exploration behavior [GO:0035641]; macrophage activation involved in immune response [GO:0002281]; MAPK cascade [GO:0000165]; mucus secretion [GO:0070254]; negative regulation of protein ubiquitination [GO:0031397]; phosphorylation [GO:0016310]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cellular glucuronidation [GO:2001031]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid catabolic process [GO:0050996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of wound healing [GO:0090303]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to morphine [GO:0043278]; synaptic transmission, GABAergic [GO:0051932]; TRAM-dependent toll-like receptor 4 signaling pathway [GO:0035669]

cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intermediate filament cytoskeleton [GO:0045111]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]

14-3-3 protein binding [GO:0071889]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity [GO:0004699]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; ethanol binding [GO:0035276]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor activator activity [GO:0030546]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR000551}. Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR000551}. Cell membrane {ECO:0000256|PIRNR:PIRNR000551}. Cytoplasm, perinuclear region {ECO:0000256|PIRNR:PIRNR000551}. Nucleus {ECO:0000256|PIRNR:PIRNR000551}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts. In passaging cells, translocated to the cell periphery. Translocated to the nucleus in PMA-treated cells. {ECO:0000256|PIRNR:PIRNR000551}.

IPR000961;IPR046349;IPR000008;IPR035892;IPR020454;IPR011009;IPR034669;IPR002219;IPR027274;IPR017892;IPR014376;IPR000719;IPR017441;IPR008271;

3.30.60.20;2.60.40.150;1.10.510.10;

A0A2I2UTQ4

FEWCPRMGRVLLAWCWALCCWGCVAPKGTQAEADPFVESPRNITGARGLVGTLRCELKVQGEPPEVTWLRDGQVLELADSTQMQVPLGEDGEDEWKVVSQLRISSLQLSDAGWYQCAVNLGGKTFLSQPGYVGLEGLPYFLEEPEDRAMAANTPFNLSCWAQGPPEPVDLLWLQDAVPLTPVMGRGPQHTLRIRGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHNLHLASRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGVGVWLGEPDPPKEPITLQASVPPHQLRLGGLHPHTPYHIRVACTSSQGPSPWTHWLPVETPEGVPLGPPENVSAMRNGSQALVRWREPRAPLQGTLLGYRLAYRGQDTPEVLMDIGLKREVTLELQGDGTVPNLTVCVAAYTAAGDGPWSHPVPLESWRPGQGQPIHLLVSEPPAPAFSWPWWYVLLGAVVAAGCVFILALFLVHRRKKETRYNSLGINEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSEREGFPAPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLCQGNRLKQPVDCLDGLYALMSRCWELNPRDRPSFSELREDLENTLKALPPAQEPDEILYVNMDEGGGHPEPLGAAGGADPLTQPDPKDSCSCLTAAEVHPAGRYVLCPSTAPGPTLPTERSSPAPPGQEDGA

Felis catus (Cat) (Felis silvestris catus)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Disulfide bond;Glycoprotein;Immunoglobulin domain;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Signal;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

blood vessel remodeling [GO:0001974]; cell maturation [GO:0048469]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; cellular response to interferon-alpha [GO:0035457]; cellular response to lipopolysaccharide [GO:0071222]; dendritic cell differentiation [GO:0097028]; erythrocyte homeostasis [GO:0034101]; establishment of localization in cell [GO:0051649]; forebrain cell migration [GO:0021885]; inflammatory response [GO:0006954]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of macrophage cytokine production [GO:0010936]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; nervous system development [GO:0007399]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; neutrophil clearance [GO:0097350]; ovulation cycle [GO:0042698]; phagocytosis [GO:0006909]; platelet activation [GO:0030168]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of pinocytosis [GO:0048549]; positive regulation of viral life cycle [GO:1903902]; secretion by cell [GO:0032940]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vagina development [GO:0060068]

actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]

ATP binding [GO:0005524]; phosphatidylserine binding [GO:0001786]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; virus receptor activity [GO:0001618]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR003961;IPR036116;IPR007110;IPR036179;IPR013783;IPR003599;IPR011009;IPR000719;IPR017441;IPR001245;IPR008266;IPR020635;

2.60.40.10;1.10.510.10;

A0A2I2UTZ7

MGAASGRPRRGPPPPLPLLLLLLPPPALALDPELHPGNFSADEAGAQLFVKSFNSSAELVMYQSTVASWEYDTNITEENARLQEEAALLNQEFAEIWGQKAKDLYDPIWQNFSDPILRRVISGVRTLGPANLPVAKRQQYNSLLSNMNRIYSTAKVCYYPNKTAICWSLDPELTHIMAISRSYSVLLYAWEGWHNAVGIPLKPLYQNFTALSNEAYKQDGFSDTGAYWRSWYDSPTFVEDLEHLYHQVEPLYLNLHAYVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWDNLYDMVVPFPNKPSLDVTSTMVKKGWNITHMFRVAEEFFTSLGLLPMPPEFWTRSMLEKPTDGRQVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDQPVSLRQGANPGFHEAIGDVLALSVSTPEHLYKIGLLDNVSNDMESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICAPIARNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHKCDIYQSTQAGAKLREALRSGSSRPWQEVLKEAIGSDTLDAQPLLNYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPVPHNYPQDIGLVTDEVEARKFVEEYDRRSQVIWNEYAEANWNYNTNITTEASKILLQKNIQMANHTLKFGTWARQFDMTSFQNDSIKRMLKKIQDLERAALPAKELEEYNQILLDMETTYSVASVCHANGTCLQLEPDLTNLMATSRKYEDLLWAWKSWRDKVGRAILPFFPKYVELANKAAKLNGYEDAGDSWRAMYEMPTLEHDLEQLYQELQPLYLNLHAYVRRALHRHYGPQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPKIDATEAMIKQGWTPRRMFEEADNFFTSLGLLPVPFEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNMEDLVVAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSINLLSSEGGGYEQDINFLMKMALDKIAFVPFSYLVDQWRWRVFDGSITKENYNQEWWNLRLKYQGLCPPVARAQGDFDPGAKFHVPSSVPYIRYFVGFVIQFQFHEALCQAAGHKGPLHTCDIYQSKEAGKRLADAMKLGFSKPWPEAMKLITGQTNMSASAMMNYFKPLLDWLLTENGRHGEKLGWPQYNWTPNSALSEGPVPGNGRVNFLGLDLEEQQARVGQWVLLFLGITLLVATLVLTQRLFSIRRHSLHQPHHGPQFGSEVELRHS

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region. {ECO:0000256|ARBA:ARBA00037200}.

3.4.-.-

CATALYTIC ACTIVITY: Reaction=H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycine; Xref=Rhea:RHEA:71487, ChEBI:CHEBI:15377, ChEBI:CHEBI:190689, ChEBI:CHEBI:190708, ChEBI:CHEBI:190710; Evidence={ECO:0000256|ARBA:ARBA00037024}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71488; Evidence={ECO:0000256|ARBA:ARBA00037024}; CATALYTIC ACTIVITY: Reaction=H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine; Xref=Rhea:RHEA:71483, ChEBI:CHEBI:15377, ChEBI:CHEBI:189868, ChEBI:CHEBI:190708, ChEBI:CHEBI:190709; Evidence={ECO:0000256|ARBA:ARBA00036262}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71484; Evidence={ECO:0000256|ARBA:ARBA00036262}; CATALYTIC ACTIVITY: Reaction=H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin; Xref=Rhea:RHEA:70675, ChEBI:CHEBI:15377, ChEBI:CHEBI:189868, ChEBI:CHEBI:189869, ChEBI:CHEBI:189870; Evidence={ECO:0000256|ARBA:ARBA00036091}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70676; Evidence={ECO:0000256|ARBA:ARBA00036091}; CATALYTIC ACTIVITY: Reaction=H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11); Xref=Rhea:RHEA:71475, ChEBI:CHEBI:15377, ChEBI:CHEBI:147362, ChEBI:CHEBI:190704, ChEBI:CHEBI:190706; Evidence={ECO:0000256|ARBA:ARBA00034019}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71476; Evidence={ECO:0000256|ARBA:ARBA00034019}; CATALYTIC ACTIVITY: Reaction=H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8); Xref=Rhea:RHEA:71463, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190694, ChEBI:CHEBI:190699; Evidence={ECO:0000256|ARBA:ARBA00035850}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71464; Evidence={ECO:0000256|ARBA:ARBA00035850}; CATALYTIC ACTIVITY: Reaction=H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9); Xref=Rhea:RHEA:71459, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190693, ChEBI:CHEBI:190700; Evidence={ECO:0000256|ARBA:ARBA00034071}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71460; Evidence={ECO:0000256|ARBA:ARBA00034071}; CATALYTIC ACTIVITY: Reaction=H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6); Xref=Rhea:RHEA:71471, ChEBI:CHEBI:15377, ChEBI:CHEBI:190692, ChEBI:CHEBI:190696, ChEBI:CHEBI:190697; Evidence={ECO:0000256|ARBA:ARBA00036862}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71472; Evidence={ECO:0000256|ARBA:ARBA00036862}; CATALYTIC ACTIVITY: Reaction=Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.; EC=3.4.15.1; Evidence={ECO:0000256|ARBA:ARBA00036868}; CATALYTIC ACTIVITY: Reaction=angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine; Xref=Rhea:RHEA:63560, ChEBI:CHEBI:15377, ChEBI:CHEBI:58506, ChEBI:CHEBI:147350, ChEBI:CHEBI:147392; EC=3.4.15.1; Evidence={ECO:0000256|ARBA:ARBA00036030}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63561; Evidence={ECO:0000256|ARBA:ARBA00036030}; CATALYTIC ACTIVITY: Reaction=bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg; Xref=Rhea:RHEA:71451, ChEBI:CHEBI:15377, ChEBI:CHEBI:132988, ChEBI:CHEBI:133147, ChEBI:CHEBI:147352; Evidence={ECO:0000256|ARBA:ARBA00035977}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71452; Evidence={ECO:0000256|ARBA:ARBA00035977}; CATALYTIC ACTIVITY: Reaction=goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate; Xref=Rhea:RHEA:71455, ChEBI:CHEBI:15377, ChEBI:CHEBI:190701, ChEBI:CHEBI:190702, ChEBI:CHEBI:190703; Evidence={ECO:0000256|ARBA:ARBA00036673}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71456; Evidence={ECO:0000256|ARBA:ARBA00036673};

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|RuleBase:RU361144}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|RuleBase:RU361144}; COFACTOR: Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00001923};

Carboxypeptidase;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix;Zinc

amyloid-beta metabolic process [GO:0050435]; angiotensin maturation [GO:0002003]; angiotensin-activated signaling pathway [GO:0038166]; arachidonic acid secretion [GO:0050482]; bradykinin catabolic process [GO:0010815]; cell proliferation in bone marrow [GO:0071838]; heart contraction [GO:0060047]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; male gonad development [GO:0008584]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of gene expression [GO:0010629]; neutrophil mediated immunity [GO:0002446]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of systemic arterial blood pressure [GO:0003084]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of angiotensin metabolic process [GO:0060177]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of synaptic plasticity [GO:0048167]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; spermatogenesis [GO:0007283]; substance P catabolic process [GO:0010814]

endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; plasma membrane [GO:0005886]

bradykinin receptor binding [GO:0031711]; carboxypeptidase activity [GO:0004180]; chloride ion binding [GO:0031404]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase binding [GO:0031434]; peptidyl-dipeptidase activity [GO:0008241]; tripeptidyl-peptidase activity [GO:0008240]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Secreted {ECO:0000256|ARBA:ARBA00004613}.

IPR001548;

A0A2I2UWD2

MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFSWMQQDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000256|HAMAP-Rule:MF_03206}.

2.3.1.199

CATALYTIC ACTIVITY: Reaction=(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39675, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:61540, ChEBI:CHEBI:76555; Evidence={ECO:0000256|ARBA:ARBA00001297}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39676; Evidence={ECO:0000256|ARBA:ARBA00001297}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence={ECO:0000256|ARBA:ARBA00001347}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36512; Evidence={ECO:0000256|ARBA:ARBA00001347}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence={ECO:0000256|ARBA:ARBA00000592}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36504; Evidence={ECO:0000256|ARBA:ARBA00000592}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence={ECO:0000256|ARBA:ARBA00001158}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36524; Evidence={ECO:0000256|ARBA:ARBA00001158}; CATALYTIC ACTIVITY: Reaction=H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35315, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57384, ChEBI:CHEBI:71407; Evidence={ECO:0000256|ARBA:ARBA00001211}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35316; Evidence={ECO:0000256|ARBA:ARBA00001211}; CATALYTIC ACTIVITY: Reaction=H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39167, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57349, ChEBI:CHEBI:57384, ChEBI:CHEBI:57385; Evidence={ECO:0000256|ARBA:ARBA00001634}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39168; Evidence={ECO:0000256|ARBA:ARBA00001634}; CATALYTIC ACTIVITY: Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence={ECO:0000256|HAMAP-Rule:MF_03206, ECO:0000256|RuleBase:RU361115}; CATALYTIC ACTIVITY: Reaction=dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:60140, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57384, ChEBI:CHEBI:62543; Evidence={ECO:0000256|ARBA:ARBA00001237}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60141; Evidence={ECO:0000256|ARBA:ARBA00001237};

PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|HAMAP-Rule:MF_03206}.

Endoplasmic reticulum;Fatty acid biosynthesis;Fatty acid metabolism;Glycoprotein;Lipid biosynthesis;Lipid metabolism;Membrane;Reference proteome;Transferase;Transmembrane;Transmembrane helix

fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]

fatty acid elongase complex [GO:0009923]

fatty acid elongase activity [GO:0009922]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03206}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03206}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

PTM: N-Glycosylated. {ECO:0000256|HAMAP-Rule:MF_03206}.

IPR030457;IPR002076;IPR033675;

A0A2I2UWK2

MADSGLGVQGSLLQLQKSLSAGDRCSAAMASYQLIRGLGQECVLSSGPSVLALQTSLVFSKDFGLLVFVRKSLSIDEFRDCREEVLKFLCVFLEKIGQKITPYSLDIKNTCTSVYTKDKAAKCRIPALDLLIKLLRTLRSSRLMDEFGIGELFSKFYGELASKTKIQDTVLEKIYELLGVLGEVHPSEMINNSENLFRAFLGELKTQMTSALREPKLPVLAGCLKGLSSLMCNFTKSMEEDPQTSREIFDFTLKAIRPQIDLKRYAVPLAGLCLFTLHASQFSTCLLDNYISVFEVLSKWCSHTNGEIKKAAHSALESFLKQISFMVAKDAEMHKDKLQYFMEQFYGIIRNTDSNSKDLSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQLFLTQTDTVDDHIYHMPSFLQSVGSVLLYLDTVPEVYTPVLEHLIVAQIDSFPRYSPKMQSVCCKAIVKVFLALVGKGPVLWNCISTVVHQGLIRICSKPVILQKGVESESEDYRASGEVRTGKWKVPTYKDYLDLFRSLLSCDQMMDFLLADEVFLFVNSSLQSLNRLLYDEFVKSVLKIIEKLDLTLEKQNVGGHEQLFVCKHPGENSTFLLICFYREILPEKHVEFFEPWVYSFAYELILQSTRLPLISGFYKLLSVAVRNAKKIKYFKGVGLKSQTQSPEDPEKYSCFALFAKFGKEVSVKMKQYKDELLASCLTFILSLPHDIIELDIRAYVPALQMAFKLGLSYPPLAEVGLNALEEWSVYICKHVIQPYYKDILPSLDGYLKISALSDETKNWEVSALSRAAQKGFNKVVLKHLKKTKNISLNEVLSLEEIRIRVVQMLGFLGGQINKNLLTATSSDEMMKKYVAWDREKRLSFAVPFIEMKPVVYLDVFLPRVTELALSASDRQTKVAACELLHSIVMFMLGKATQMPESGQGFPPMYQLYKRTFPVLLQLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLETILDGIVDPVDSTLRDFCGRCIREFLKWSIKQTTPQQQEKSPVNTKSLFKRLYSFALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYLESLALAHTDEKSLGTIQQCCDAIDHLRRIIEKKHVSLNKVKKRRRPRGFPPAASLCLLDVVHWLLAHCGRPQTECRHKSIELFYKFVPLLPGNKSPSLWLKEILKSKDPSFLINMFEGGGGGCGRPSGILAQPTLFHLQGPFSLRAALQWMDMLLAALECYNTFTEKKTLAAPEVLGTETQSSLWKAVTFFLESIAMHDITAAEKCFGTGAVGHRPSPQEGERYNYSKCTIVVRIMEFTTTLLSISPEGWKLLEKDLRNNTNLMKLLVKTLCEPSSIGFNIGDVLVMNRLPDVCVDLMKALKKSPYKDILEMHLKEELTAQSIEELCAVDLYGPDASVDRAKLASVVSACKQLHRAGFLHVVLPFQSADQYSVGTKLLSLVYKSIAPGDERQCLPSLDPSCKRLASGLLELAFAFGVQCEHLVNLLLDTAVLSLPPSGAFQRNMASFCHGEYFYSLFSETVNTELLKNLDLAVLELLKSSVDNPKMVSAILNGMLDQSFRDRASQRHQGLKLASTILHNWKKWDSWWAKDSAPESKTAVLTLLAKILQIDSSFNTNHSAFPEVFTTYASLLGDSKLGLHLKGQAVILLPFFTNLTGSSLEDLKHVLEKLIVSNFPMKSEEFPPGTLRYNNYVDCMKKFLDALELSQSPILLQLMTEILCREQQHVMEELFQSTFKKIAGNSCVTQLALLESVYRMFKRDDLLSNVTRQAFVDRCLLTLLWHCSPNALIEFFSKIVVDAIDVLKSRFTKLNESTFDTQITKKMGCYKILDVMYSRLPKDDVHSKESKINQVFHGSCVTEGSELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFTELKFYQGFLLSEKPEKNLLIFENLIDLKRCYTFPVEVEVPMERRKKYIEIRKEAREAGNGDSGGPHYISSLSYLADSSLSEEMSQFDFSTGVQSYSYGSQDPKSTTGHFRRRDYKDPVIQDAVLELEMDELNQHECMATMTALIKHMQRNQILPKREEGSVPSSLPPWMKFLHDKLGNPSVSLNIRLFLAKLVINTEEVFRPYAKYWLSPLLQLVVSENNGGEGIHYMVVEIVVTLLSWTGIATPVGVPKDEVLANRLLHFLMKHVFHQKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSSKDPNSKDNSVGIQLLGIIMANNLPPYDPKCGIESVKYFQALVTNMSFVKYKEVYAAAAEVLGLILQYVTKKENILEDLVYELIVKQLKQHQNTMEDKFIVCLNKAVKNFPPLADRFMNTVFFLLPKFHGVMKTLCLEVVLCRAEEITDLYLQLKSKDFIQVMRYRDDERQKVCLDIIYKMMAKLKPVELRELLNPVVEFISHPSPVCREQMYNILMWVHDNYRDPESQADEDSREIFKLAKDVLIQGLIDENVGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATDFLLEMTSMSPDYPNPVFEHPLSECEFQEYTIDSDWRFRSTVLTPMFIETQATQSVLQTRTQEGSLPVQGAMAKQIRATQQQYDFTPTQTADGRSSFNWLTGSSIDPLMDYTVSSSDSSSSSLLFAHKKSEKAQRSPLKLVGPDFGKKRLGLPGDEVDNKAKGKVKILRLRRRFIKDQEKLSLIYARKGVAEQKREKEIKSELKMKHDAQVILYRSYRQGDLPDIQIKYSSLITPLQAVAQRDPIIAKQLFGSLFSGIIKEMDKHKTVSEKNIITQKLLQDFNHFLNTTFSFFPPFVSCIQEISCQHTDLLSLNPASVSAGCLASLQQPVGIRLLEEALLQLLPPEPPAKRFQGRTRLSPDVVRWMELAKLYRSIGEYDVLRGIFSSEIGTKQITQNAVLAEARSDYSEAAKQYNEALNKQEWVDGEPTEAEKDFWELASLDCYNQLAEWKSLAYCSIVSVDNENPPDLNKMWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDEAVNKEVQKALIELHYSQELSLLYILQDDVDRAKYYIENCIQIFMQNYSSIDVLLHRSRLTKVQSVQTIIEIQEFISFISKQGNLSSQAPLRRLLKTWTNRYPDATMDPMNIWDDIITNRCFFLSKIEEKLLLPPDDHSMSMDGDGDPSDGMEVQEQGEEVCSLIKNCVFSMKMKMVESARKQNNFSLAMKLLKELHRDSKTRDGWQVKWVHSYSRLSHSRSRAQSCPEQVLTALKTVSLLGESISSYLSKNVLAFHDQNILLGTTYRIIADALSREPTCLAEIEESKARRILDLSGSSSENTDKVIAGLYQRAFHHLSEAVRTAEEEAQPSLKGQGPVASMTEAYMTLVDFCDQQLRKEEESASVIESVELQMYPALVVDKMLKALKLHSSEARLKFPRLLQIIELYPEETLSLMTKEMSSIPCWQFIGWISHMVALLDKEEAVAVQHTVEEIADNYPQAIIYPFIISSESYSFKDTSAGHKNKEFVARIKIKLDQGGVIQDFISALEQLSNPEMLFKDWTDDIKVELAKTPVNKKHIEKMYERMYAALGDPEVPGLGAFRKRFIQAFGKEFDKHFGKGGSKLPGMKLRDFTDITNSLLSKMCRDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGKGKPVPEYHARITGFDERVKVMASIRKPKRIIIRGHDEKEYPFLVKGGEDLRQDQRIEQLFEVMNVLLSRDAACSQRNMQLKTYRVIPMTSRLGLIEWIENTFTLKDLLLSHMSQEEKAAYTSDPRAPPHEYREWLAKMSGKHDVGAYVSMFKAASRTETVTSFRRRESKVPADLLKRAFLKMSTGPEAFLALRSHFASSHALLCISHWILGIGDRHLNNFMVSMETGEMIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKEAGVMCSVMVHALRAFRSHSDLLINTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEVNVTEKNWYPRQKIHYAKRKLAGANPAVITCDELLLGHENVLAFADYVAVARGNKDHNIRAQQPESGLSEEAQVKCLIDQATDPNILGRTWIGWEPWM

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

ATP-binding;DNA damage;DNA repair;Kinase;Nucleotide-binding;Nucleus;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase

activation of innate immune response [GO:0002218]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular response to insulin stimulus [GO:0032869]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immature B cell differentiation [GO:0002327]; immunoglobulin V(D)J recombination [GO:0033152]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; maturation of 5.8S rRNA [GO:0000460]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of protein phosphorylation [GO:0001933]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of platelet formation [GO:1905221]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of epithelial cell proliferation [GO:0050678]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of smooth muscle cell proliferation [GO:0048660]; response to gamma radiation [GO:0010332]; small-subunit processome assembly [GO:0034462]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]

chromatin [GO:0000785]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]; transcription regulator complex [GO:0005667]

ATP binding [GO:0005524]; DNA-dependent protein kinase activity [GO:0004677]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone H2AXS139 kinase activity [GO:0035979]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; U3 snoRNA binding [GO:0034511]

SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.

IPR011989;IPR016024;IPR037706;IPR046804;IPR046803;IPR012582;IPR045581;IPR003152;IPR011009;IPR000403;IPR036940;IPR018936;IPR003151;IPR014009;

1.25.10.10;1.10.1070.11;

A0A2I2UWL3

MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ

Felis catus (Cat) (Felis silvestris catus)

3.1.3.16

CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000256|ARBA:ARBA00001512}; CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000256|ARBA:ARBA00001482, ECO:0000256|RuleBase:RU004273};

COFACTOR: Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Evidence={ECO:0000256|ARBA:ARBA00001965}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947};

Calmodulin-binding;Hydrolase;Iron;Metal-binding;Reference proteome

calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; dendrite morphogenesis [GO:0048813]; dephosphorylation [GO:0016311]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; keratinocyte differentiation [GO:0030216]; multicellular organismal response to stress [GO:0033555]; negative regulation of angiotensin-activated signaling pathway [GO:0110062]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of gene expression [GO:0010629]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of cell migration [GO:0030335]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of saliva secretion [GO:0046878]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein import into nucleus [GO:0006606]; regulation of cell proliferation involved in kidney morphogenesis [GO:0061006]; renal filtration [GO:0097205]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; transition between fast and slow fiber [GO:0014883]

calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]; Z disc [GO:0030018]

ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; cyclosporin A binding [GO:0016018]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]

IPR004843;IPR029052;IPR041751;IPR043360;IPR006186;

3.60.21.10;

A0A2I2UWU9

MAQAGSAGRGAAGQKPAGAAPGCALWRWALGLLWLALAAAGSSRRQWPVPYKRFSFRPEPDPYCQAKYTFCPTGSPIPIMKDDDVIEVFRLQAPVWEFKYGNLLGHLKIMHDAIGFKSTLTGQNYTMEWYELFQLGNCTFPHLRPEMNAPFWCNQGAACFFEGIDDIHWKANGTLVQVATISGNTFNKMAKWVKWDNETGIYYETWTVQASPEKGAETWFESYDCSKFVLRTYNKLAELGAEFKKIETNYTRIFLYSGEPTYLGNETSIFGPTGNQTLALAVKRFYYPFKPHSSTKEFLFSFLQIFDAVIIHRQFYLFYNFEYWFLPMKFPFIKITYEEIPLPNRNDTLSGL

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation. {ECO:0000256|ARBA:ARBA00044494}.

3.1.2.22

CATALYTIC ACTIVITY: Reaction=2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77599, ChEBI:CHEBI:139150, ChEBI:CHEBI:139152, ChEBI:CHEBI:197411; Evidence={ECO:0000256|ARBA:ARBA00044481}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77600; Evidence={ECO:0000256|ARBA:ARBA00044481}; CATALYTIC ACTIVITY: Reaction=2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77607, ChEBI:CHEBI:44859, ChEBI:CHEBI:197411, ChEBI:CHEBI:197415; Evidence={ECO:0000256|ARBA:ARBA00044455}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77608; Evidence={ECO:0000256|ARBA:ARBA00044455}; CATALYTIC ACTIVITY: Reaction=2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77603, ChEBI:CHEBI:197411, ChEBI:CHEBI:197412, ChEBI:CHEBI:197414; Evidence={ECO:0000256|ARBA:ARBA00044460}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77604; Evidence={ECO:0000256|ARBA:ARBA00044460}; CATALYTIC ACTIVITY: Reaction=2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77611, ChEBI:CHEBI:197411, ChEBI:CHEBI:197413, ChEBI:CHEBI:197416; Evidence={ECO:0000256|ARBA:ARBA00044453}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77612; Evidence={ECO:0000256|ARBA:ARBA00044453}; CATALYTIC ACTIVITY: Reaction=2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77619, ChEBI:CHEBI:77717, ChEBI:CHEBI:197411, ChEBI:CHEBI:197425; Evidence={ECO:0000256|ARBA:ARBA00044472}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77620; Evidence={ECO:0000256|ARBA:ARBA00044472}; CATALYTIC ACTIVITY: Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence={ECO:0000256|ARBA:ARBA00037021}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234; Evidence={ECO:0000256|ARBA:ARBA00037021};

Glycoprotein;Reference proteome;Signal

brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601]

cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775]

bis(monoacylglycero)phosphate synthase activity [GO:0160121]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; mannose binding [GO:0005537]

IPR026138;

A0A2I2UXM8

MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRSSPNVDKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKTQMDKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLSLQLEQESNKRVLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLTTQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETNSMLTKDLELLRKENEELTDKMRRTEEEYKLKKEEEINNLKATYEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSAKTSS

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. {ECO:0000256|PIRNR:PIRNR037568}.

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001127}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence={ECO:0000256|ARBA:ARBA00001127}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001416}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence={ECO:0000256|ARBA:ARBA00001416};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|PIRNR:PIRNR037568};

ATP-binding;Cell membrane;Cell projection;Coiled coil;Cytoplasm;Cytoskeleton;Golgi apparatus;Kinase;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc;Zinc-finger

actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; bleb assembly [GO:0032060]; blood vessel diameter maintenance [GO:0097746]; canonical NF-kappaB signal transduction [GO:0007249]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; mitotic cytokinesis [GO:0000281]; motor neuron apoptotic process [GO:0097049]; mRNA destabilization [GO:0061157]; myoblast migration [GO:0051451]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of motor neuron apoptotic process [GO:2000672]; negative regulation of phosphorylation [GO:0042326]; neuron projection arborization [GO:0140058]; phosphorylation [GO:0016310]; podocyte cell migration [GO:0090521]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; protein localization to plasma membrane [GO:0072659]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of keratinocyte differentiation [GO:0045616]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of neuron differentiation [GO:0045664]; regulation of synapse maturation [GO:0090128]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]

amyloid-beta complex [GO:0106003]; bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]

aspartic-type endopeptidase inhibitor activity [GO:0019828]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, bleb {ECO:0000256|ARBA:ARBA00043945}. Cell projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR000961;IPR046349;IPR011072;IPR011009;IPR002219;IPR011993;IPR001849;IPR000719;IPR017441;IPR020684;IPR037310;IPR015008;IPR008271;

1.20.5.340;3.30.60.20;2.30.29.30;1.20.5.730;1.10.510.10;

A0A2I2UYM7

MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN

Felis catus (Cat) (Felis silvestris catus)

2.7.1.153

CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence={ECO:0000256|ARBA:ARBA00023981}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293; Evidence={ECO:0000256|ARBA:ARBA00023981};

PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. {ECO:0000256|ARBA:ARBA00004805}.

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Transferase

actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; autosome genomic imprinting [GO:0141068]; cardiac muscle cell contraction [GO:0086003]; cell migration [GO:0016477]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to membrane [GO:1905477]; regulation of cellular respiration [GO:0043457]; regulation of multicellular organism growth [GO:0040014]; regulation of protein phosphorylation [GO:0001932]; relaxation of cardiac muscle [GO:0055119]; response to muscle stretch [GO:0035994]; vascular endothelial growth factor signaling pathway [GO:0038084]

cytoplasm [GO:0005737]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]

1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; insulin receptor substrate binding [GO:0043560]; protein kinase activator activity [GO:0030295]

IPR016024;IPR035892;IPR011009;IPR000403;IPR036940;IPR018936;IPR002420;IPR003113;IPR001263;IPR042236;IPR000341;IPR037704;IPR015433;IPR029071;

2.60.40.150;1.10.1070.11;1.25.40.70;

A0A2I2UYT7

MACPWQFLFKAKSHQYNLTEETDINNNVGKAVRAPSGLVTQDDPKCHGLSKHRNEPPQSLTGIVKTVPESLRKLDMPPSACPRHVRIKNWGSGMTFQDTLHHKAKGDLACRSKSCLGAIMNPKSLTRGPRDKPTPPDELLPQAIEFVNQYYSSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHVRYATNNGNIRSAITVFPQRSDGKHDFRIWNAQLIRYAGYQMPDGTILGDPASVEFTQLCIDLGWKPKYGRFDVVPLVLQADGGDPELFEIPPDLVLEVPMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDRAVIEINVAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPISGSITPVFHQEMLNYVLSPFFYYQVEAWKTHIWQDEKRRPRRRKIPFKVLVQAVLFASMLMRKTMASRVRATILFATETGKSETLARDLGALFSCAFNPKILCMDQYGLSNLEEEQLLLVVTSTFGNGDSPGNGEKLKKSLFMLKELTNKFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEEAFRSWAVQTFKAACETFDVRGKHRIQIPKLYTSNVTWDPHHYRLVRDSQPLDLNKALGSMHAKNVFTMRLKSQRNLQSAKSSRTTLLVELSCEDSHRLSYLPGEHLGVFPGNQLALVKGILERVVDGPAPHQPVHLETLSESGSYWVRDKRLPPCSLSQALTYFLDITTPPTQLLLRKLAQLATEEAERQRLEILCQPSEYNKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRYYSISSSRACAPTEVHLTVAVLTYRTRDGQGPLHHGVCSTWLSSLKPQDPVPCFVRSAGGFQLPEDPSRPCILIGPGTGIAPFRSFWQQRLHDAEHKGLRGSRMTLVFGCRRPDEDHLYREEMLEMAQKGVLHEVHTAYSRLPGQPKVYVQDILRQQLASEVLRVLHKEQGHLYVCGDVRMARDVAQTLKHLLAATLSLSEEQVEDYFFQLKVRWLVCGSGVQIKDTGKGIRTRRVRLRTVLHLKRILEVTGGQSEMGC

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions. {ECO:0000256|PIRNR:PIRNR000333}.

1.14.13.39

CATALYTIC ACTIVITY: Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence={ECO:0000256|ARBA:ARBA00035595}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19898; Evidence={ECO:0000256|ARBA:ARBA00035595};

COFACTOR: Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence={ECO:0000256|ARBA:ARBA00001950}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FAD. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FMN. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000256|ARBA:ARBA00001970, ECO:0000256|PIRNR:PIRNR000333};

Calmodulin-binding;FAD;Flavoprotein;FMN;Heme;Iron;Metal-binding;NADP;Oxidoreductase;Reference proteome

arginine catabolic process [GO:0006527]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; prostaglandin secretion [GO:0032310]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of insulin secretion [GO:0050796]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; superoxide metabolic process [GO:0006801]

cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]

arginine binding [GO:0034618]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; protein homodimerization activity [GO:0042803]; tetrahydrobiopterin binding [GO:0034617]

IPR003097;IPR017927;IPR001094;IPR008254;IPR001709;IPR029039;IPR039261;IPR023173;IPR044943;IPR044940;IPR044944;IPR012144;IPR004030;IPR036119;IPR001433;IPR017938;

3.40.50.360;3.90.440.10;3.40.50.80;2.40.30.10;

A0A2I2UZM2

MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVEMGSEPRVPLMMWSLRKCLLAI

Felis catus (Cat) (Felis silvestris catus)

3.6.4.10

CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence={ECO:0000256|ARBA:ARBA00001629};

ATP-binding;mRNA processing;mRNA splicing;Nucleotide-binding;Reference proteome;Spliceosome

ATP metabolic process [GO:0046034]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; clathrin coat disassembly [GO:0072318]; late endosomal microautophagy [GO:0061738]; mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of supramolecular fiber organization [GO:1902904]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein refolding [GO:0042026]; protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740]; regulation of cell cycle [GO:0051726]; regulation of postsynapse organization [GO:0099175]; regulation of protein stability [GO:0031647]; RNA splicing [GO:0008380]; slow axonal transport [GO:1990832]

autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; glycinergic synapse [GO:0098690]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; postsynaptic specialization membrane [GO:0099634]; presynaptic cytosol [GO:0099523]; protein folding chaperone complex [GO:0101031]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; terminal bouton [GO:0043195]

ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein disaggregase activity [GO:0140545]; ATP-dependent protein folding chaperone [GO:0140662]; C3HC4-type RING finger domain binding [GO:0055131]; clathrin-uncoating ATPase activity [GO:1990833]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; phosphatidylserine binding [GO:0001786]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]

IPR043129;IPR018181;IPR029048;IPR029047;IPR013126;

1.20.1270.10;3.30.30.30;3.30.420.40;

A0A2I2UZN5

MAALGITVALLVWMATLMLISVWKQIYSSWKLPPGPFPLPIIGNLLQLDFKNVPKSLTKLAERYGPVFTLYLGSQRTVVLHGYKAVKEVLLDYKNEFSGRGEIYAFEAHKDKGITFNNGPSWKDTRRLSLSILRDYGMGKRANEEQIQREVPFLLEAFRGTQGQPFDPTFVLGYAPCNVISDILFRKRFDYTDQTGLRIQKLFNENFHLLSTNWLQLYNIFPSYMRYLPGNHRKVIKNVYEIKSYTAARVKEHEESLDPNCPRDFTDSLLLEMRKERYTKEPWFTFDNIAATIADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRLEMPYMDAVVHEIQRFIDLLPSNLPHEAIQDTMFRGYVIPKGTVVVPTLDSLLFDNQEFPDPEKFKPEHFLNESGKFKYSDYFKAFSAGKRVCVGEGLARMELFLFLSAILQHFNLKPLVDPKDIDLSPSTIGFAKIPPRYKLCVIPRSGV

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. {ECO:0000256|RuleBase:RU368050}.

1.14.13.n7; 1.14.14.1

CATALYTIC ACTIVITY: Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:132025; Evidence={ECO:0000256|ARBA:ARBA00000615, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50089; Evidence={ECO:0000256|ARBA:ARBA00000615, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence={ECO:0000256|ARBA:ARBA00001354, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50077; Evidence={ECO:0000256|ARBA:ARBA00001354, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence={ECO:0000256|ARBA:ARBA00000326, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39788; Evidence={ECO:0000256|ARBA:ARBA00000326, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50096, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30807, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132031; Evidence={ECO:0000256|ARBA:ARBA00000338, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50097; Evidence={ECO:0000256|ARBA:ARBA00000338, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000256|ARBA:ARBA00000089}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence={ECO:0000256|ARBA:ARBA00000089}; CATALYTIC ACTIVITY: Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; Evidence={ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence={ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence={ECO:0000256|ARBA:ARBA00001427, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence={ECO:0000256|ARBA:ARBA00001427, ECO:0000256|RuleBase:RU368050};

COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000256|ARBA:ARBA00001971, ECO:0000256|PIRSR:PIRSR602401-1, ECO:0000256|RuleBase:RU368050};

PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000256|ARBA:ARBA00004872, ECO:0000256|RuleBase:RU368050}.

Endoplasmic reticulum;Fatty acid metabolism;Heme;Iron;Lipid metabolism;Membrane;Metal-binding;Microsome;Mitochondrion;Mitochondrion inner membrane;Monooxygenase;NADP;Oxidoreductase;Reference proteome

epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]

cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]

arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU368050}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368050}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174, ECO:0000256|RuleBase:RU368050}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174, ECO:0000256|RuleBase:RU368050}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU368050}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368050}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR001128;IPR017972;IPR002401;IPR008070;IPR036396;

1.10.630.10;

A0A2I2V040

MVYAKSWTLKKHFEGSPTHGNFELKTVELPPLNNGEVLLEALFLTVDPYMRVAAKRLKEGDTMMGQQVARVVESKNSAFPTGTMVVASSGWTTHSISDGKDLEKLPAEWPDTLPVSLALGTVGMTGLTAYFGLLDICGVKGGETVMVNAAAGAVGSAVGQIAKLKGCKVVGAAGSDEKVAYLKKLGYDVAFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNIVIPQMKKFGRIAICGAISVYNTTRPLPPGPPPENIIYQQLRMEGFIVTRWQGDVRQKALKDLLTWVLEGKIQYREYITEGFENMPAAFMGMLKGENLGKTIVKAK

Felis catus (Cat) (Felis silvestris catus)

1.3.1.48; 1.3.1.74

CATALYTIC ACTIVITY: Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974, ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213; Evidence={ECO:0000256|ARBA:ARBA00023498}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590; Evidence={ECO:0000256|ARBA:ARBA00023548}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence={ECO:0000256|ARBA:ARBA00023544}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586; Evidence={ECO:0000256|ARBA:ARBA00023544}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence={ECO:0000256|ARBA:ARBA00023543}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594; Evidence={ECO:0000256|ARBA:ARBA00023543}; CATALYTIC ACTIVITY: Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208, ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133346; Evidence={ECO:0000256|ARBA:ARBA00023517}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209; Evidence={ECO:0000256|ARBA:ARBA00023517}; CATALYTIC ACTIVITY: Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112; Evidence={ECO:0000256|ARBA:ARBA00023553}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738; Evidence={ECO:0000256|ARBA:ARBA00023553}; CATALYTIC ACTIVITY: Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974; Evidence={ECO:0000256|ARBA:ARBA00023496}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205; Evidence={ECO:0000256|ARBA:ARBA00023496}; CATALYTIC ACTIVITY: Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; Evidence={ECO:0000256|ARBA:ARBA00023696}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618; Evidence={ECO:0000256|ARBA:ARBA00023696}; CATALYTIC ACTIVITY: Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH; Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748; Evidence={ECO:0000256|ARBA:ARBA00023504}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782; Evidence={ECO:0000256|ARBA:ARBA00023504}; CATALYTIC ACTIVITY: Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276; Evidence={ECO:0000256|ARBA:ARBA00024160}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790; Evidence={ECO:0000256|ARBA:ARBA00024160}; CATALYTIC ACTIVITY: Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; Evidence={ECO:0000256|ARBA:ARBA00023507}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739; Evidence={ECO:0000256|ARBA:ARBA00023507}; CATALYTIC ACTIVITY: Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH; Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455; Evidence={ECO:0000256|ARBA:ARBA00023691}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614; Evidence={ECO:0000256|ARBA:ARBA00023691}; CATALYTIC ACTIVITY: Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH; Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741; Evidence={ECO:0000256|ARBA:ARBA00023530}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786; Evidence={ECO:0000256|ARBA:ARBA00023530}; CATALYTIC ACTIVITY: Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence={ECO:0000256|ARBA:ARBA00034052}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778; Evidence={ECO:0000256|ARBA:ARBA00034052}; CATALYTIC ACTIVITY: Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309; Evidence={ECO:0000256|ARBA:ARBA00023545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609; Evidence={ECO:0000256|ARBA:ARBA00023545};

Fatty acid metabolism;Hydroxylation;Lipid metabolism;Oxidoreductase;Prostaglandin metabolism;Reference proteome

prostaglandin metabolic process [GO:0006693]

cytoplasm [GO:0005737]

13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; 2-alkenal reductase (NADP+) activity [GO:0035798]

IPR013149;IPR041694;IPR011032;IPR045010;IPR036291;IPR020843;IPR014190;

3.90.180.10;3.40.50.720;

A0A2I2V0G4

MSPCGRARRHTSRGAMAVLAWKFPRTRLPVGASALCVVVLCWLYVFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARVFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGSKSHLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDTPLQPTS

Felis catus (Cat) (Felis silvestris catus)

2.4.3.8

CATALYTIC ACTIVITY: Reaction=[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate = [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+); Xref=Rhea:RHEA:77371, Rhea:RHEA-COMP:18881, Rhea:RHEA-COMP:18935, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:197322; Evidence={ECO:0000256|ARBA:ARBA00044457}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77372; Evidence={ECO:0000256|ARBA:ARBA00044457}; CATALYTIC ACTIVITY: Reaction=a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41768, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78445, ChEBI:CHEBI:78447; Evidence={ECO:0000256|ARBA:ARBA00043743}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41769; Evidence={ECO:0000256|ARBA:ARBA00043743}; CATALYTIC ACTIVITY: Reaction=a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41764, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78436, ChEBI:CHEBI:78438; Evidence={ECO:0000256|ARBA:ARBA00043833}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41765; Evidence={ECO:0000256|ARBA:ARBA00043833}; CATALYTIC ACTIVITY: Reaction=a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+); Xref=Rhea:RHEA:77295, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:79214, ChEBI:CHEBI:79216; Evidence={ECO:0000256|ARBA:ARBA00044471}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77296; Evidence={ECO:0000256|ARBA:ARBA00044471}; CATALYTIC ACTIVITY: Reaction=a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:47576, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:87787; Evidence={ECO:0000256|ARBA:ARBA00043723}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47577; Evidence={ECO:0000256|ARBA:ARBA00043723}; CATALYTIC ACTIVITY: Reaction=a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41760, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60065, ChEBI:CHEBI:60377, ChEBI:CHEBI:78436; Evidence={ECO:0000256|ARBA:ARBA00043813}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41761; Evidence={ECO:0000256|ARBA:ARBA00043813}; CATALYTIC ACTIVITY: Reaction=a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41772, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78452, ChEBI:CHEBI:78455; Evidence={ECO:0000256|ARBA:ARBA00043792}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41773; Evidence={ECO:0000256|ARBA:ARBA00043792}; CATALYTIC ACTIVITY: Reaction=an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+); Xref=Rhea:RHEA:19313, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:140308, ChEBI:CHEBI:140309; EC=2.4.3.8; Evidence={ECO:0000256|ARBA:ARBA00036589};

PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004760}.; PATHWAY: Protein modification; protein glycosylation. {ECO:0000256|ARBA:ARBA00004922}.; PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.

Disulfide bond;Glycoprotein;Golgi apparatus;Lipid metabolism;Membrane;Reference proteome;Signal-anchor;Sphingolipid metabolism;Transferase;Transmembrane;Transmembrane helix

cellular response to heat [GO:0034605]; epithelial cell proliferation [GO:0050673]; N-glycan processing [GO:0006491]; oligosaccharide metabolic process [GO:0009311]; positive regulation of epithelial cell proliferation [GO:0050679]; protein glycosylation [GO:0006486]; sphingolipid metabolic process [GO:0006665]

Golgi membrane [GO:0000139]

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity [GO:0003828]

SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.

IPR001675;IPR038578;IPR012163;

3.90.1480.20;

A0A2I2V1Z0

MGDGGLTISGTMGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSDVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDKGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEERPTFDYLRSVLEDFFTATEGQYQPQP

Felis catus (Cat) (Felis silvestris catus)

2.7.10.2

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000256|ARBA:ARBA00001149, ECO:0000256|RuleBase:RU362096};

ATP-binding;Cell membrane;Cytoplasm;Kinase;Lipoprotein;Membrane;Nucleotide-binding;Palmitate;Phosphoprotein;Reference proteome;SH2 domain;SH3 domain;Transferase;Tyrosine-protein kinase

B cell receptor signaling pathway [GO:0050853]; Fc-gamma receptor signaling pathway [GO:0038094]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; phosphorylation [GO:0016310]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of T cell activation [GO:0050870]; response to xenobiotic stimulus [GO:0009410]; T cell differentiation [GO:0030217]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242]

ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004423}.

IPR011009;IPR035850;IPR035749;IPR000719;IPR017441;IPR001245;IPR000980;IPR036860;IPR036028;IPR001452;IPR008266;IPR020635;

3.30.505.10;2.30.30.40;1.10.510.10;

A0A2I2V255

MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASAGPLGCCR

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. {ECO:0000256|RuleBase:RU368052}.

2.7.11.24

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000494}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000088};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|RuleBase:RU368052};

ATP-binding;Biological rhythms;Kinase;Magnesium;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase

cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to reactive oxygen species [GO:0034614]; JNK cascade [GO:0007254]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein metabolic process [GO:0051247]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; stress-activated MAPK cascade [GO:0051403]

cytoplasm [GO:0005737]; nucleus [GO:0005634]

ATP binding [GO:0005524]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; JUN kinase activity [GO:0004705]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase binding [GO:0120283]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368052}.

IPR011009;IPR003527;IPR008351;IPR000719;IPR008271;

1.10.510.10;

A0A2I2V321

MASAAPLAMMWEEVTCPICLDPVVEPVSIECGHSFCHDCISQVGKDGGGVCPVCQHIFLLRNVRPNWPLANMVDNLKQIGQSAKEGMQRERCEVHGEKLHLFCEEDGKILCWVCSQSQNHRNHHMVPIEEAAQEYKEKLQVALGNLRKGQRLAEELEVDIAMKRAAWKSQVETHKLRIHTEFVQQQNFLAAEEQRQLQKLEMEEKEQLRILGEREATLAQKSQALQELVVELEKRSRGSALELLQEVKSVLGRSECWNLKNLDITPPDLRSVCLVPGLKRMLRTYGVHITLDPYTANPWLILSEDRRQVRLGGSRQEVPENEGRFDTYPMVLGAQFFDSGKVYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSPQNGFWTIWLWNKQKYEAGTSPQTPLHLRVPPCQVGIFLDYEASTVSFYNITDHGSLIYTFSECAFAGPLRPFFSTGFNDEGSNSAPLVLRPLGVGW

Felis catus (Cat) (Felis silvestris catus)

2.3.2.27

PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906}.

Coiled coil;Metal-binding;Reference proteome;Zinc;Zinc-finger

innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of viral entry into host cell [GO:0046598]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; pyroptosis [GO:0070269]; regulation of protein localization [GO:0032880]; regulation of viral entry into host cell [GO:0046596]; response to type II interferon [GO:0034341]; stress granule disassembly [GO:0035617]; suppression of viral release by host [GO:0044790]

cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]

protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR001870;IPR043136;IPR003879;IPR013320;IPR006574;IPR035831;IPR003877;IPR000315;IPR020457;IPR018957;IPR001841;IPR013083;IPR017907;

2.60.120.920;3.30.160.60;3.30.40.10;

A0A2I2V3L1

MLNLEFSVEKAKIIFEKAAPKCSSSAVRFRGVTAGTMKMDMEDADMTLWTEADFEEKCTYIVNDHPWDCGADGGTSVQAEASLPRNLLFKYATNSKEVIGVVSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSHPKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDCYRSNISPLAPEKDADDFRKNGSPEMPFYPRVVYPLRAPLPENFLKAYGMERPTYITHSPIPSSTTPSPSARSSPDQSLKSCSPHSSPGNTVSPLAPCPPEHRDSYAYLNAPYGPEGLGSYPGYAPAPHLPPAFIPSYNAHYSKYLLPPYGVNCNGLGAMGNMGGVGNLGLFPRLYPVYSSLLGGGSLPHPLLSPASLPSSLPSDGARRPLQPDHAREVLVPAPHSAFSLPGAAASMKDRASSPTSGSPTAGTAASAEHVVQPKATSAALAAPGSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAHCHKSYIHLCSLKVHLKGNCPVAPATGIPLEDLTRINEEIEKFDISDNADRLEDVEDNIDVTSVVEKEILAMVRKEKEETGLKVSLQRNMGNGLLSGCSLYESSDPSLMKLAHSNPLPLGPVKVKQETVEPMDP

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. {ECO:0000256|PIRNR:PIRNR013212}.

2.1.1.-

Metal-binding;Methyltransferase;Reference proteome;Transferase;Zinc;Zinc-finger

aorta development [GO:0035904]; artery morphogenesis [GO:0048844]; cell fate commitment [GO:0045165]; coronary vasculature development [GO:0060976]; eye photoreceptor cell development [GO:0042462]; gene expression [GO:0010467]; germ cell development [GO:0007281]; heart valve development [GO:0003170]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; maternal placenta development [GO:0001893]; methylation [GO:0032259]; morphogenesis of a branching structure [GO:0001763]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; post-embryonic development [GO:0009791]; regulation of cell population proliferation [GO:0042127]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of natural killer cell differentiation [GO:0032823]; regulation of NK T cell differentiation [GO:0051136]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal bipolar neuron differentiation [GO:0060040]; sebum secreting cell proliferation [GO:1990654]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281]

cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone methyltransferase binding [GO:1990226]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR013212}. Cytoplasm {ECO:0000256|PIRNR:PIRNR013212}.

IPR016608;IPR044413;IPR001214;IPR046341;IPR036236;IPR013087;

3.30.160.60;2.170.270.10;

A0A2I2Y4E9

VLNYYFEFLAKGAEEMETVTIAGLAGKDPVQCSLDVFICPDASLEDAKKEGPYDIIILPGGNLGAQNLPESASVKEILKEQENQKGLIATICAGPTALMAHEISFGSKVTTLPLAKDKMMNGSHYTYSENRVEKDGPRTSFEFVLTIVEALSSKEMAAQVKAPLVLKD

Gorilla gorilla gorilla (Western lowland gorilla)

3.5.1.124

CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+); Xref=Rhea:RHEA:57264, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:58189, ChEBI:CHEBI:141574; Evidence={ECO:0000256|ARBA:ARBA00000867}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+); Xref=Rhea:RHEA:57304, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:58115, ChEBI:CHEBI:141576; Evidence={ECO:0000256|ARBA:ARBA00000833}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+); Xref=Rhea:RHEA:57252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:37565, ChEBI:CHEBI:141571; Evidence={ECO:0000256|ARBA:ARBA00000164}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+); Xref=Rhea:RHEA:57248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:61429, ChEBI:CHEBI:141572; Evidence={ECO:0000256|ARBA:ARBA00000484}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate; Xref=Rhea:RHEA:57260, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:58189, ChEBI:CHEBI:141573; Evidence={ECO:0000256|ARBA:ARBA00001318}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate; Xref=Rhea:RHEA:57268, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:58115, ChEBI:CHEBI:141575; Evidence={ECO:0000256|ARBA:ARBA00000480}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate; Xref=Rhea:RHEA:57256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:37565, ChEBI:CHEBI:141570; Evidence={ECO:0000256|ARBA:ARBA00001515}; CATALYTIC ACTIVITY: Reaction=H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate; Xref=Rhea:RHEA:57244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:61429, ChEBI:CHEBI:141569; Evidence={ECO:0000256|ARBA:ARBA00000267}; CATALYTIC ACTIVITY: Reaction=H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]; Xref=Rhea:RHEA:57192, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:14845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:29969, ChEBI:CHEBI:141554; EC=3.5.1.124; Evidence={ECO:0000256|ARBA:ARBA00000247}; CATALYTIC ACTIVITY: Reaction=H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate; Xref=Rhea:RHEA:49552, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12429, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:29969, ChEBI:CHEBI:131709; EC=3.5.1.124; Evidence={ECO:0000256|ARBA:ARBA00001233}; CATALYTIC ACTIVITY: Reaction=H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]; Xref=Rhea:RHEA:57188, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:14844, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:29965, ChEBI:CHEBI:141553; EC=3.5.1.124; Evidence={ECO:0000256|ARBA:ARBA00000302}; CATALYTIC ACTIVITY: Reaction=H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate; Xref=Rhea:RHEA:49548, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:12428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:29965, ChEBI:CHEBI:131708; EC=3.5.1.124; Evidence={ECO:0000256|ARBA:ARBA00001300}; CATALYTIC ACTIVITY: Reaction=H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]; Xref=Rhea:RHEA:57196, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14846, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:29950, ChEBI:CHEBI:141555; EC=3.5.1.124; Evidence={ECO:0000256|ARBA:ARBA00001659}; CATALYTIC ACTIVITY: Reaction=H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate; Xref=Rhea:RHEA:49556, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:12430, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:29950, ChEBI:CHEBI:131710; EC=3.5.1.124; Evidence={ECO:0000256|ARBA:ARBA00000760}; CATALYTIC ACTIVITY: Reaction=an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+); Xref=Rhea:RHEA:57296, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:14857, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:85445, ChEBI:CHEBI:141579; Evidence={ECO:0000256|ARBA:ARBA00000456}; CATALYTIC ACTIVITY: Reaction=an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+); Xref=Rhea:RHEA:57292, Rhea:RHEA-COMP:14855, Rhea:RHEA-COMP:14859, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:74269, ChEBI:CHEBI:141581; Evidence={ECO:0000256|ARBA:ARBA00000739}; CATALYTIC ACTIVITY: Reaction=an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate; Xref=Rhea:RHEA:57300, Rhea:RHEA-COMP:11367, Rhea:RHEA-COMP:14856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:85445, ChEBI:CHEBI:141578; Evidence={ECO:0000256|ARBA:ARBA00001733}; CATALYTIC ACTIVITY: Reaction=an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate; Xref=Rhea:RHEA:57288, Rhea:RHEA-COMP:14855, Rhea:RHEA-COMP:14858, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:24996, ChEBI:CHEBI:74269, ChEBI:CHEBI:141580; Evidence={ECO:0000256|ARBA:ARBA00001123};

Autophagy;Fertilization;Oxidation;Reference proteome;Zymogen

autophagy [GO:0006914]; glycolate biosynthetic process [GO:0046295]; glyoxal metabolic process [GO:1903189]; response to oxidative stress [GO:0006979]; single fertilization [GO:0007338]

cytoplasm [GO:0005737]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]

oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; protein deglycase activity [GO:0036524]

SUBCELLULAR LOCATION: Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}.

IPR029062;IPR006287;IPR002818;

3.40.50.880;

A0A2I2Y584

MLQASSCPLGCVLLTPRLCLCSQDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWAGLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIHASFLSRITFWWITGLIVRGYRQPLEDSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVTVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAVHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYSILLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGVVYRKALVITSSARKSSTVGEIVNLMSVDAQRFVDLATYINMIWSAPLQVIVALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVRHVSLRAPKPGMSYHAWPLYMFCVCDIITISHWAFCLQVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTQSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAELLRTYASTEQEQDAEENGITGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFSETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHISVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPNKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGSPSDLLQQRGLFYSMAKDAGLV

Gorilla gorilla gorilla (Western lowland gorilla)

7.6.2.2; 7.6.2.3

CATALYTIC ACTIVITY: Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00000793}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60129; Evidence={ECO:0000256|ARBA:ARBA00000793}; CATALYTIC ACTIVITY: Reaction=2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:74887, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143093, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036427}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024162}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38964; Evidence={ECO:0000256|ARBA:ARBA00024162}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out); Xref=Rhea:RHEA:38951, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00001064}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38952; Evidence={ECO:0000256|ARBA:ARBA00001064}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out); Xref=Rhea:RHEA:60160, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143658, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036384}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60161; Evidence={ECO:0000256|ARBA:ARBA00036384}; CATALYTIC ACTIVITY: Reaction=ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate; Xref=Rhea:RHEA:33147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64677, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036199}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33148; Evidence={ECO:0000256|ARBA:ARBA00036199};

ATP-binding;Membrane;Nucleotide-binding;Reference proteome;Signal;Transmembrane;Transmembrane helix;Transport

cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; phospholipid translocation [GO:0045332]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]

apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lateral plasma membrane [GO:0016328]

ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR003593;IPR011527;IPR036640;IPR003439;IPR017871;IPR005292;IPR027417;

1.20.1560.10;3.40.50.300;

A0A2I2Y6E6

MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDEIINFLFSQCMPPNYYTILYFSSLNLFWGLEHTKCSSTCGLIFEYMCEENTLIHGNVCAKNILLIREEDRKTGNLPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKVTNILIIWLRPFKLFTFIKLAERKMYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.10.2

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000256|ARBA:ARBA00001149, ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};

ATP-binding;Chromatin regulator;Kinase;Membrane;Nucleotide-binding;Nucleus;Reference proteome;SH2 domain;Transferase;Tyrosine-protein kinase

cellular response to dexamethasone stimulus [GO:0071549]; cellular response to interleukin-3 [GO:0036016]; cellular response to lipopolysaccharide [GO:0071222]; collagen-activated signaling pathway [GO:0038065]; cytokine-mediated signaling pathway [GO:0019221]; erythrocyte differentiation [GO:0030218]; extrinsic apoptotic signaling pathway [GO:0097191]; granulocyte-macrophage colony-stimulating factor signaling pathway [GO:0038157]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-3-mediated signaling pathway [GO:0038156]; interleukin-5-mediated signaling pathway [GO:0038043]; intracellular signal transduction [GO:0035556]; mammary gland epithelium development [GO:0061180]; microglial cell activation [GO:0001774]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; phosphorylation [GO:0016310]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NK T cell proliferation [GO:0051142]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-embryonic hemopoiesis [GO:0035166]; post-translational protein modification [GO:0043687]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; response to antibiotic [GO:0046677]; symbiont-induced defense-related programmed cell death [GO:0034050]; transcription by RNA polymerase II [GO:0006366]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

caveola [GO:0005901]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; granulocyte macrophage colony-stimulating factor receptor complex [GO:0030526]; nucleoplasm [GO:0005654]

ATP binding [GO:0005524]; growth hormone receptor binding [GO:0005131]; heme binding [GO:0020037]; histone binding [GO:0042393]; histone H3Y41 kinase activity [GO:0035401]; identical protein binding [GO:0042802]; interleukin-12 receptor binding [GO:0005143]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase binding [GO:0019901]; SH2 domain binding [GO:0042169]

SUBCELLULAR LOCATION: Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR019749;IPR035963;IPR019748;IPR000299;IPR041155;IPR041046;IPR041381;IPR037838;IPR035860;IPR011009;IPR011993;IPR000719;IPR017441;IPR001245;IPR000980;IPR036860;IPR008266;IPR020635;IPR016251;IPR020693;

2.30.29.30;3.30.505.10;1.10.510.10;

A0A2I2Y750

MLPTPVELHVHLDGSIKPETILYYGRRRGIALPANTAGGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQTEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPEVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYDRLRQENMHFEICPWSSYLTGAWKPDTEHAVVRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGRFLSGLLGSCPVLAPVWLSVGLLARCPSILGQRHVCVMTPWFLGPGWEQRLIRSVCFL

Gorilla gorilla gorilla (Western lowland gorilla)

3.5.4.4

CATALYTIC ACTIVITY: Reaction=2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+); Xref=Rhea:RHEA:28190, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17256, ChEBI:CHEBI:28938, ChEBI:CHEBI:28997; EC=3.5.4.4; Evidence={ECO:0000256|ARBA:ARBA00034443}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28191; Evidence={ECO:0000256|ARBA:ARBA00034443}; CATALYTIC ACTIVITY: Reaction=adenosine + H(+) + H2O = inosine + NH4(+); Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=3.5.4.4; Evidence={ECO:0000256|ARBA:ARBA00001600}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409; Evidence={ECO:0000256|ARBA:ARBA00001600};

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947};

Hydrolase;Nucleotide metabolism;Reference proteome

adenosine catabolic process [GO:0006154]; allantoin metabolic process [GO:0000255]; alpha-beta T cell differentiation [GO:0046632]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; AMP salvage [GO:0044209]; B cell proliferation [GO:0042100]; calcium-mediated signaling [GO:0019722]; dAMP catabolic process [GO:0046059]; dATP catabolic process [GO:0046061]; deoxyadenosine catabolic process [GO:0006157]; embryonic digestive tract development [GO:0048566]; germinal center B cell differentiation [GO:0002314]; germinal center formation [GO:0002467]; GMP salvage [GO:0032263]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; leukocyte migration [GO:0050900]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mature B cell apoptotic process [GO:0002901]; mucus secretion [GO:0070254]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of mucus secretion [GO:0070256]; negative regulation of penile erection [GO:0060407]; negative regulation of thymocyte apoptotic process [GO:0070244]; penile erection [GO:0043084]; Peyer's patch development [GO:0048541]; placenta development [GO:0001890]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of germinal center formation [GO:0002636]; positive regulation of heart rate [GO:0010460]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; smooth muscle contraction [GO:0006939]; T cell activation [GO:0042110]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymocyte apoptotic process [GO:0070242]; trophectodermal cell differentiation [GO:0001829]; xanthine biosynthetic process [GO:0046111]

anchoring junction [GO:0070161]; cytoplasmic vesicle lumen [GO:0060205]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; lysosome [GO:0005764]

2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side {ECO:0000256|ARBA:ARBA00004296}. Cytoplasmic vesicle lumen {ECO:0000256|ARBA:ARBA00004321}.

IPR006650;IPR028893;IPR001365;IPR006330;IPR032466;

3.20.20.140;

A0A2I2Y7N2

MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTLRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREITEQYLKNSLIILHSSIHSTSILWSTCYYKLSSITCYRDE

Gorilla gorilla gorilla (Western lowland gorilla)

1.2.1.36

CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate; Xref=Rhea:RHEA:16177, ChEBI:CHEBI:15035, ChEBI:CHEBI:15036, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence={ECO:0000256|ARBA:ARBA00036070}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16178; Evidence={ECO:0000256|ARBA:ARBA00036070}; CATALYTIC ACTIVITY: Reaction=all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans-13,14-dihydroretinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:75119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:194182, ChEBI:CHEBI:194183; Evidence={ECO:0000256|ARBA:ARBA00035998}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75120; Evidence={ECO:0000256|ARBA:ARBA00035998}; CATALYTIC ACTIVITY: Reaction=all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence={ECO:0000256|ARBA:ARBA00035919}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42081; Evidence={ECO:0000256|ARBA:ARBA00035919};

PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000256|ARBA:ARBA00004891}.

Oxidoreductase;Reference proteome

9-cis-retinoic acid biosynthetic process [GO:0042904]; blood vessel development [GO:0001568]; cardiac muscle tissue development [GO:0048738]; cell population proliferation [GO:0008283]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; face development [GO:0060324]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; lung development [GO:0030324]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of vascular endothelial cell proliferation [GO:1905562]; response to cytokine [GO:0034097]; retinal metabolic process [GO:0042574]; retinoic acid receptor signaling pathway involved in somitogenesis [GO:0090242]; ureter maturation [GO:0035799]

cytoplasm [GO:0005737]

3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal dehydrogenase activity [GO:0001758]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR016161;IPR016163;IPR016160;IPR029510;IPR016162;IPR015590;

A0A2I2Y902

MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLRVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGGGAGPTSSSGDGRCLLSNPTFPCRRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVGLLWRRLYSPVKDLYGAIKATKGRAQWLMPIIPALWEAEAGGSLEPSSSRPAWATWQNTLSTKNTKIAGRGGSRL

Gorilla gorilla gorilla (Western lowland gorilla)

7.6.2.5

CATALYTIC ACTIVITY: Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate; Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344, ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence={ECO:0000256|ARBA:ARBA00024259}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19262; Evidence={ECO:0000256|ARBA:ARBA00024259}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate; Xref=Rhea:RHEA:61360, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58687, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00001865}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61361; Evidence={ECO:0000256|ARBA:ARBA00001865}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out); Xref=Rhea:RHEA:61336, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57306, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024279}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61337; Evidence={ECO:0000256|ARBA:ARBA00024279}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out); Xref=Rhea:RHEA:66772, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167480, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024277}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66773; Evidence={ECO:0000256|ARBA:ARBA00024277}; CATALYTIC ACTIVITY: Reaction=ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out); Xref=Rhea:RHEA:66776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167479, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024289}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66777; Evidence={ECO:0000256|ARBA:ARBA00024289}; CATALYTIC ACTIVITY: Reaction=ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate; Xref=Rhea:RHEA:66768, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:167478, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024261}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66769; Evidence={ECO:0000256|ARBA:ARBA00024261}; CATALYTIC ACTIVITY: Reaction=ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate; Xref=Rhea:RHEA:66664, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:131725, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024278}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66665; Evidence={ECO:0000256|ARBA:ARBA00024278}; CATALYTIC ACTIVITY: Reaction=ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate; Xref=Rhea:RHEA:66680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57309, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00024263}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66681; Evidence={ECO:0000256|ARBA:ARBA00024263};

Disulfide bond;Golgi apparatus;Lysosome;Membrane;Mitochondrion;Mitochondrion outer membrane;Reference proteome;Secreted;Translocase;Transmembrane;Transmembrane helix;Transport

brain development [GO:0007420]; cellular detoxification of cadmium ion [GO:0098849]; heme metabolic process [GO:0042168]; heme transport [GO:0015886]; melanosome assembly [GO:1903232]; porphyrin-containing compound biosynthetic process [GO:0006779]; skin development [GO:0043588]; transmembrane transport [GO:0055085]

cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; melanosome membrane [GO:0033162]; mitochondrial outer membrane [GO:0005741]; multivesicular body membrane [GO:0032585]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]

ABC-type heme transporter activity [GO:0015439]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562]; heme binding [GO:0020037]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.

IPR011527;IPR036640;IPR003439;IPR032410;IPR027417;IPR039421;

1.20.1560.10;3.40.50.300;

A0A2I2YAR4

LGAGGTMGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDKACGSLAVDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.10.2

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000256|ARBA:ARBA00001149, ECO:0000256|RuleBase:RU362096};

ATP-binding;Cell membrane;Cytoplasm;Kinase;Lipoprotein;Membrane;Nucleotide-binding;Palmitate;Phosphoprotein;Reference proteome;SH2 domain;SH3 domain;Transferase;Tyrosine-protein kinase

B cell receptor signaling pathway [GO:0050853]; Fc-gamma receptor signaling pathway [GO:0038094]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; intracellular zinc ion homeostasis [GO:0006882]; phosphorylation [GO:0016310]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of T cell activation [GO:0050870]; response to xenobiotic stimulus [GO:0009410]; T cell differentiation [GO:0030217]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; membrane raft [GO:0045121]; pericentriolar material [GO:0000242]

ATP binding [GO:0005524]; ATPase binding [GO:0051117]; CD4 receptor binding [GO:0042609]; CD8 receptor binding [GO:0042610]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol 3-kinase binding [GO:0043548]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]; SH2 domain binding [GO:0042169]; signaling receptor binding [GO:0005102]; T cell receptor binding [GO:0042608]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004423}.

IPR011009;IPR035850;IPR035749;IPR000719;IPR017441;IPR001245;IPR000980;IPR036860;IPR036028;IPR001452;IPR008266;IPR020635;

3.30.505.10;2.30.30.40;1.10.510.10;

A0A2I2YB49

MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.11

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.11; Evidence={ECO:0000256|ARBA:ARBA00001036}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.11; Evidence={ECO:0000256|ARBA:ARBA00000541};

ATP-binding;cAMP;Kinase;Lipoprotein;Mitochondrion;Myristate;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cold [GO:0070417]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to heat [GO:0034605]; cellular response to parathyroid hormone stimulus [GO:0071374]; mesoderm formation [GO:0001707]; mRNA processing [GO:0006397]; negative regulation of glycolytic process through fructose-6-phosphate [GO:1904539]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of TORC1 signaling [GO:1904262]; neural tube closure [GO:0001843]; phosphorylation [GO:0016310]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein export from nucleus [GO:0046827]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein export from nucleus [GO:0006611]; protein kinase A signaling [GO:0010737]; protein localization to lipid droplet [GO:1990044]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cell cycle [GO:0051726]; regulation of osteoblast differentiation [GO:0045667]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein processing [GO:0070613]; sperm capacitation [GO:0048240]

acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane raft [GO:0044853]; sperm flagellum [GO:0036126]

AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein domain specific binding [GO:0019904]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR000961;IPR011009;IPR000719;IPR017441;IPR008271;IPR044109;

1.10.510.10;

A0A2I2YBF5

MADPIMDLFDDPNLFGLDSLTDDSFNQVTQDPIEEALGLPSSLDSLDQMNQDGGGGDVGNSSASELVPPPEETAPTELPKESTAPAPESITLHDYTTQPASQEQPAQPVLQTSTPTSGLLQVSKSQEILSQGNPFMGVSATAVSSSSAGGQPPQSAPKIVILKAPPSSSVTGAHVAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSGNTVLAAKVPGNQAAVQRIVQPSRPVKQLVLQPVKGSAPAGNPGATGPPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQGHRHVVLGSLPGKIVLQGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQKIQIVPQPPSSQPQPQQPPSTQPVTLSSVQQAQIMGPGQSPGQRLSVPVKVVLQPQAGSSQGASSGLSVVKVLSASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSPREDEESSIQKRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRIVKKELPSGQYTEAEEFFVKYKNYSYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDKDNGEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILTEFREACHIIPHDFHLQAMVRSAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFAKASFVASENRTDISLDDPNFWQKWAKKADLDMDLLNSKNNLVIDTPRVRKQTRHFSTLKDDDLVEFSDLESEDDERPRSRRHDRHHAYGRTDCFRVEKHLLVYGWGRWRDILSHGRFKRRMTERDVETICRAILVYCLLHYRGDENIKGFIWDLISPAENGKTKELQNHSVFDVSPFPGLSIPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKHQCNKVLLRVRMLYYLRQEVIGDQAEKVLGGAIASEIDIWFPVVDQLEVPTTWWDSEADKSLLIGVFKHGYEKYNTMRADPALCFLEKAGRPDDKAIAAEHRVLDNFSDIVEGVDFDKDCEDPEYKPLQGPPKDQDDEGDPLMMMDEEISVIDGDEAQVTQQPGHLFWPPGSALTARLRRLVTAYQRSYKREQMKIEAAERGDRRRRRCEAAFKLKEIARREKQQRWTRREQTDFYRVVSTFGVEYDPDTMQFHWDRFRTFARLDKKTDESLTKYFHGFVAMCRQVCRLPPAAGDEPPDPNLFIEPITEERASRTLYRIELLRRLREQVLCHPLLEDRLALCQPPGPELPKWWEPVRHDGELLRGAARHGVSQTDCNIMQDPDFSFLAARMNYMQNHQAGAPAPSLSRCSTPLLHQQYTSRTASPLPLRPDAPVEKSPEETATQVPSLESLTLKLEHEVVARSRPTPQDYEMRVSPSDTTPLVSRSVPPVKLEDEDDSDSELDLSKLSPSSSSSSSSSSSSSSTDESEDEKEEKLTDQSRSKLYDEESLLSLTMSQDGFPNEDGEQMTPELLLLQERQRASEWPKDRVLINRIDLVCQAVLSGKWPSSRRSQEMVTGGILGPGNHLLDSPSLTPGEYGDSPVPTPRSSSAASMAEEEASAVSTAAAQFTKLRRGMDEKEFTVQIKDEEGLKLTFQKHKLMANGVMGDGHPLFHKKKGNRKKLVELEVECMEEPNHLDVDLETRIPVINKVDGTLLVGEDAPRRAELEMWLQGHPEFAVDPRFLAYMEDRRKQKWQRCKKNNKAELNCLGMEPVQTANSRNGKKGHHTETVFNRVLPGPIAPESSKKRARRMRPDLSKMMALMQGGSTGSLSLHNTFQHSSSGLQSVSSLGHSSATSASLPFMPFVMGGAPSSPHVDSSTMLHHHHHHPHPHHHHHHHPGLRAPGYPSSPATTASGTTLRLPPLQPEEDDDEDEEDDDDLSQGYDSSERDFSLIDDPMMPANSDSSEDADD

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. {ECO:0000256|HAMAP-Rule:MF_03071}.

3.6.4.12

CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00001665, ECO:0000256|HAMAP-Rule:MF_03071};

Activator;ATP-binding;Chromatin regulator;DNA-binding;Helicase;Hydrolase;Isopeptide bond;Nucleotide-binding;Nucleus;Reference proteome;Repeat;Repressor;Transcription;Transcription regulation;Ubl conjugation;Wnt signaling pathway

brain development [GO:0007420]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; prepulse inhibition [GO:0060134]; social behavior [GO:0035176]; Wnt signaling pathway [GO:0016055]

chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleus [GO:0005634]

ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; histone binding [GO:0042393]; methylated histone binding [GO:0035064]; p53 binding [GO:0002039]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03071}. Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. {ECO:0000256|HAMAP-Rule:MF_03071}.

PTM: Sumoylated. {ECO:0000256|HAMAP-Rule:MF_03071}.

IPR006576;IPR037259;IPR034724;IPR016197;IPR000953;IPR023780;IPR014001;IPR001650;IPR027417;IPR038718;IPR049730;IPR000330;

2.40.50.40;3.40.5.120;1.10.10.60;3.40.50.300;3.40.50.10810;

A0A2I2YCS6

MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEKFPTFPFCGLQKGATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQIRRPDESKGVASRVGSLKARLPSCSSTYSVSEVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000256|RuleBase:RU365090}.

2.10.1.1; 2.7.7.75

CATALYTIC ACTIVITY: Reaction=ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate; Xref=Rhea:RHEA:31331, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58698, ChEBI:CHEBI:62727; Evidence={ECO:0000256|RuleBase:RU365090}; CATALYTIC ACTIVITY: Reaction=adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin; Xref=Rhea:RHEA:35047, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:36264, ChEBI:CHEBI:62727, ChEBI:CHEBI:71302, ChEBI:CHEBI:456215; Evidence={ECO:0000256|RuleBase:RU365090};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU365090};

PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000256|ARBA:ARBA00005046, ECO:0000256|RuleBase:RU365090}.

Magnesium;Metal-binding;Molybdenum;Molybdenum cofactor biosynthesis;Reference proteome;Transferase

establishment of synaptic specificity at neuromuscular junction [GO:0007529]; gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; response to metal ion [GO:0010038]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]; postsynaptic specialization membrane [GO:0099634]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin cofactor binding [GO:0043546]; molybdopterin molybdotransferase activity [GO:0061599]; nitrate reductase activity [GO:0008940]

IPR036425;IPR001453;IPR008284;IPR038987;IPR005111;IPR036688;IPR005110;IPR036135;

3.40.980.10;2.40.340.10;3.90.105.10;2.170.190.11;

A0A2I2YCX7

MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACIEAKHDKYMADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGWVEDY

Gorilla gorilla gorilla (Western lowland gorilla)

2.3.2.27

CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};

Coiled coil;Reference proteome;Repeat;TPR repeat

cellular response to misfolded protein [GO:0071218]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of proteolysis [GO:0045862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein stabilization [GO:0050821]; regulation of glucocorticoid metabolic process [GO:0031943]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; protein folding chaperone complex [GO:0101031]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018]

G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; misfolded protein binding [GO:0051787]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; R-SMAD binding [GO:0070412]; TPR domain binding [GO:0030911]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]

IPR045202;IPR041312;IPR011990;IPR019734;IPR003613;IPR013083;

6.10.140.2020;1.25.40.10;3.30.40.10;

A0A2I2YDT1

MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ

Gorilla gorilla gorilla (Western lowland gorilla)

3.1.3.16

CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000256|ARBA:ARBA00001512}; CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000256|ARBA:ARBA00001482, ECO:0000256|RuleBase:RU004273};

COFACTOR: Name=Fe(3+); Xref=ChEBI:CHEBI:29034; Evidence={ECO:0000256|ARBA:ARBA00001965}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947};

Calmodulin-binding;Hydrolase;Iron;Metal-binding;Reference proteome

calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; dendrite morphogenesis [GO:0048813]; dephosphorylation [GO:0016311]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; keratinocyte differentiation [GO:0030216]; multicellular organismal response to stress [GO:0033555]; negative regulation of angiotensin-activated signaling pathway [GO:0110062]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of gene expression [GO:0010629]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of cell migration [GO:0030335]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerulus development [GO:0090193]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of saliva secretion [GO:0046878]; positive regulation of transcription by RNA polymerase II [GO:0045944]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein import into nucleus [GO:0006606]; regulation of cell proliferation involved in kidney morphogenesis [GO:0061006]; renal filtration [GO:0097205]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; transition between fast and slow fiber [GO:0014883]

calcineurin complex [GO:0005955]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]; Z disc [GO:0030018]

ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; cyclosporin A binding [GO:0016018]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; protein dimerization activity [GO:0046983]

IPR004843;IPR029052;IPR041751;IPR043360;IPR006186;

3.60.21.10;

A0A2I2YE01

MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGSRYVAQTGLELLASSNPPASSYQSAGMIGDSCCNPLSMGAVKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQTLAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG

Gorilla gorilla gorilla (Western lowland gorilla)

3.1.2.22

CATALYTIC ACTIVITY: Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence={ECO:0000256|ARBA:ARBA00000072};

Disulfide bond;Hydrolase;Reference proteome;Signal

adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; brain development [GO:0007420]; grooming behavior [GO:0007625]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organization [GO:0031579]; negative regulation of cell growth [GO:0030308]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; neurotransmitter secretion [GO:0007269]; pinocytosis [GO:0006907]; positive regulation of pinocytosis [GO:0048549]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; visual perception [GO:0007601]

axon [GO:0030424]; dendrite [GO:0030425]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]

long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; lysophosphatidic acid binding [GO:0035727]; palmitoyl-(protein) hydrolase activity [GO:0008474]; sulfatide binding [GO:0120146]

IPR029058;IPR002472;

3.40.50.1820;

A0A2I2YGX5

MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTVGETYGKDITSRGKDKPIADVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.5.2

CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000256|ARBA:ARBA00000249}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00000249};

GTP-binding;Isopeptide bond;Membrane;Nucleotide-binding;Reference proteome

actin filament organization [GO:0007015]; cell chemotaxis [GO:0060326]; cell projection assembly [GO:0030031]; cortical cytoskeleton organization [GO:0030865]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity [GO:0007163]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; motor neuron axon guidance [GO:0008045]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of interleukin-23 production [GO:0032707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rac protein signal transduction [GO:0016601]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; ruffle assembly [GO:0097178]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; substrate adhesion-dependent cell spreading [GO:0034446]

actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; trans-Golgi network [GO:0005802]

GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; thioesterase binding [GO:0031996]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004423}.

IPR027417;IPR005225;IPR001806;IPR003578;

3.40.50.300;

A0A2I2YI12

MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEVRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVLFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000256|RuleBase:RU367132}.

3.4.22.54

CATALYTIC ACTIVITY: Reaction=Broad endopeptidase activity.; EC=3.4.22.54; Evidence={ECO:0000256|ARBA:ARBA00023702, ECO:0000256|RuleBase:RU367132};

Calcium;Cytoplasm;Hydrolase;Metal-binding;Nucleus;Protease;Reference proteome;Repeat;Thiol protease

calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; programmed cell death [GO:0012501]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of myoblast differentiation [GO:0045661]; sarcomere organization [GO:0045214]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]

calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; ligase regulator activity [GO:0055103]; molecular adaptor activity [GO:0060090]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU367132}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.

IPR033883;IPR022684;IPR022682;IPR022683;IPR036213;IPR029531;IPR011992;IPR018247;IPR002048;IPR038765;IPR000169;IPR001300;

2.60.120.380;3.90.70.10;1.10.238.10;

A0A2I2YIF0

MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELREYQSTINTVLPGGISCFKFASQICCRVKSHYIAQAGLEFLASNSWPQAILLPQPPKALGLQV

Gorilla gorilla gorilla (Western lowland gorilla)

1.14.11.53

CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57900, Rhea:RHEA-COMP:13573, Rhea:RHEA-COMP:13574, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; Evidence={ECO:0000256|ARBA:ARBA00000560}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57904, Rhea:RHEA-COMP:15030, Rhea:RHEA-COMP:15031, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85958, ChEBI:CHEBI:85959; Evidence={ECO:0000256|ARBA:ARBA00000383}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57896, Rhea:RHEA-COMP:11518, Rhea:RHEA-COMP:11519, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85958, ChEBI:CHEBI:85959; Evidence={ECO:0000256|ARBA:ARBA00000305}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:54576, Rhea:RHEA-COMP:10242, Rhea:RHEA-COMP:12312, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence={ECO:0000256|ARBA:ARBA00001575}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49520, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=1.14.11.53; Evidence={ECO:0000256|ARBA:ARBA00033605};

COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|ARBA:ARBA00001954};

Cytoplasm;Dioxygenase;Iron;Metal-binding;Nucleus;Oxidoreductase;Reference proteome

adipose tissue development [GO:0060612]; DNA dealkylation involved in DNA repair [GO:0006307]; mRNA destabilization [GO:0061157]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of brown fat cell differentiation [GO:0090335]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; temperature homeostasis [GO:0001659]

cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]

broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; tRNA demethylase activity [GO:1990984]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.

IPR037151;IPR032868;IPR024366;IPR038413;IPR024367;

2.60.120.590;1.20.58.1470;

A0A2I2YJV8

LPSGPFXXXXCPKPSGRVSIMAGSLTGLLLLQAVSWASGEWCPCIPKSFSYSSVACVCNATYCAFSRYKSRTEYRTIQANCTGTGKHYTLHPPGQKFQKVKGFGRAVTDAGALNILALSPPAQNLLLKCCDFSICTYTYVDTPDDFQLHNFSLPEEDTKLEIPLIHRALQLAQRPVSLLASPWSSPTRLKTRGVGNGKGSLKGQPRDIYHQTWARYIVKEGISKDHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYVDFLAPAKATLRETHHLFPNTVLFASEAFWEQSVRLGSWDRGMQYSHSIITPPLSHVTLTYTLWGPPVLKPPVPCGRLDRLEPIIVDITKHMFYKQPMFYHLGHFSKFIPEGSERVGLVASQKNDLDAVALMHPDGSTVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ

Gorilla gorilla gorilla (Western lowland gorilla)

3.2.1.45

CATALYTIC ACTIVITY: Reaction=1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine; Xref=Rhea:RHEA:70255, ChEBI:CHEBI:16113, ChEBI:CHEBI:72956, ChEBI:CHEBI:73432, ChEBI:CHEBI:189066; Evidence={ECO:0000256|ARBA:ARBA00033703}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70256; Evidence={ECO:0000256|ARBA:ARBA00033703}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70257; Evidence={ECO:0000256|ARBA:ARBA00033703}; CATALYTIC ACTIVITY: Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose; Xref=Rhea:RHEA:14297, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639; EC=3.2.1.46; Evidence={ECO:0000256|ARBA:ARBA00033698}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14298; Evidence={ECO:0000256|ARBA:ARBA00033698}; CATALYTIC ACTIVITY: Reaction=a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside; Xref=Rhea:RHEA:70235, ChEBI:CHEBI:16113, ChEBI:CHEBI:18390, ChEBI:CHEBI:52639, ChEBI:CHEBI:189066; Evidence={ECO:0000256|ARBA:ARBA00033611}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70236; Evidence={ECO:0000256|ARBA:ARBA00033611}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70237; Evidence={ECO:0000256|ARBA:ARBA00033611}; CATALYTIC ACTIVITY: Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose; Xref=Rhea:RHEA:13269, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639; EC=3.2.1.45; Evidence={ECO:0000256|ARBA:ARBA00001013}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13270; Evidence={ECO:0000256|ARBA:ARBA00001013}; CATALYTIC ACTIVITY: Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside; Xref=Rhea:RHEA:58264, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:22801, ChEBI:CHEBI:52639; Evidence={ECO:0000256|ARBA:ARBA00033647}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58265; Evidence={ECO:0000256|ARBA:ARBA00033647}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58266; Evidence={ECO:0000256|ARBA:ARBA00033647}; CATALYTIC ACTIVITY: Reaction=a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside; Xref=Rhea:RHEA:70239, ChEBI:CHEBI:16113, ChEBI:CHEBI:52639, ChEBI:CHEBI:189067, ChEBI:CHEBI:189068; Evidence={ECO:0000256|ARBA:ARBA00033608}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70240; Evidence={ECO:0000256|ARBA:ARBA00033608}; CATALYTIC ACTIVITY: Reaction=beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine; Xref=Rhea:RHEA:70315, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:74450, ChEBI:CHEBI:76302; Evidence={ECO:0000256|ARBA:ARBA00035592}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70316; Evidence={ECO:0000256|ARBA:ARBA00035592}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70317; Evidence={ECO:0000256|ARBA:ARBA00035592}; CATALYTIC ACTIVITY: Reaction=beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine; Xref=Rhea:RHEA:70311, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:72961, ChEBI:CHEBI:84719; Evidence={ECO:0000256|ARBA:ARBA00033636}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70312; Evidence={ECO:0000256|ARBA:ARBA00033636}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70313; Evidence={ECO:0000256|ARBA:ARBA00033636}; CATALYTIC ACTIVITY: Reaction=beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine; Xref=Rhea:RHEA:58324, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:77996, ChEBI:CHEBI:139140; Evidence={ECO:0000256|ARBA:ARBA00033685}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58325; Evidence={ECO:0000256|ARBA:ARBA00033685}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58326; Evidence={ECO:0000256|ARBA:ARBA00033685}; CATALYTIC ACTIVITY: Reaction=beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine; Xref=Rhea:RHEA:70307, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:72956, ChEBI:CHEBI:76297; Evidence={ECO:0000256|ARBA:ARBA00033694}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70308; Evidence={ECO:0000256|ARBA:ARBA00033694}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70309; Evidence={ECO:0000256|ARBA:ARBA00033694}; CATALYTIC ACTIVITY: Reaction=beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine; Xref=Rhea:RHEA:70303, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495, ChEBI:CHEBI:45815, ChEBI:CHEBI:65222; Evidence={ECO:0000256|ARBA:ARBA00033641}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70304; Evidence={ECO:0000256|ARBA:ARBA00033641}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70305; Evidence={ECO:0000256|ARBA:ARBA00033641}; CATALYTIC ACTIVITY: Reaction=beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine; Xref=Rhea:RHEA:70251, ChEBI:CHEBI:16113, ChEBI:CHEBI:77996, ChEBI:CHEBI:189067, ChEBI:CHEBI:189081; Evidence={ECO:0000256|ARBA:ARBA00033633}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70252; Evidence={ECO:0000256|ARBA:ARBA00033633}; CATALYTIC ACTIVITY: Reaction=cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose; Xref=Rhea:RHEA:11956, ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:16113, ChEBI:CHEBI:17495; Evidence={ECO:0000256|ARBA:ARBA00033646}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11957; Evidence={ECO:0000256|ARBA:ARBA00033646};

PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.; PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000256|ARBA:ARBA00004731}.

Glycosidase;Glycosyltransferase;Hydrolase;Lipid metabolism;Reference proteome;Signal;Sphingolipid metabolism;Transferase

antigen processing and presentation [GO:0019882]; autophagosome organization [GO:1905037]; brain morphogenesis [GO:0048854]; cell maturation [GO:0048469]; cellular response to starvation [GO:0009267]; cerebellar Purkinje cell layer formation [GO:0021694]; cholesterol metabolic process [GO:0008203]; determination of adult lifespan [GO:0008340]; glucosylceramide catabolic process [GO:0006680]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; lipid glycosylation [GO:0030259]; lipid storage [GO:0019915]; lymphocyte migration [GO:0072676]; lysosome organization [GO:0007040]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; mitophagy [GO:0000423]; motor behavior [GO:0061744]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein-containing complex assembly [GO:0031333]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization [GO:1904925]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; pyramidal neuron differentiation [GO:0021859]; regulation of membrane potential [GO:0042391]; regulation of TOR signaling [GO:0032006]; respiratory electron transport chain [GO:0022904]; T cell differentiation in thymus [GO:0033077]

endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802]

galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; signaling receptor binding [GO:0005102]; steryl-beta-glucosidase activity [GO:0050295]

SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000256|ARBA:ARBA00004207}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004207}; Lumenal side {ECO:0000256|ARBA:ARBA00004207}.

IPR033452;IPR001139;IPR033453;IPR017853;

3.20.20.80;

A0A2I2YKG4

MAGLGPGGGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEVPRPWLPQGSPRVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000946}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569, ECO:0000256|PIRNR:PIRNR000550};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR000550-4}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. {ECO:0000256|PIRSR:PIRSR000550-4};

ATP-binding;Biological rhythms;Calcium;Cell projection;Cytoplasm;Kinase;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Synapse;Synaptosome;Transferase;Zinc;Zinc-finger

chemical synaptic transmission [GO:0007268]; chemosensory behavior [GO:0007635]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein ubiquitination [GO:0031397]; phosphorylation [GO:0016310]; positive regulation of mismatch repair [GO:0032425]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of circadian rhythm [GO:0042752]; regulation of phagocytosis [GO:0050764]; regulation of response to food [GO:0032095]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to morphine [GO:0043278]; response to pain [GO:0048265]; rhythmic process [GO:0048511]

calyx of Held [GO:0044305]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynaptic cytosol [GO:0099523]; synaptic membrane [GO:0097060]

ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.

IPR000961;IPR046349;IPR000008;IPR035892;IPR020454;IPR011009;IPR002219;IPR017892;IPR000719;IPR017441;IPR014375;IPR008271;

3.30.60.20;2.60.40.150;1.10.510.10;

A0A2I2YKU8

MGCCSSSDPRREDDLRAREKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000256|HAMAP-Rule:MF_03171}.

2.7.4.3; 2.7.4.6

CATALYTIC ACTIVITY: Reaction=ADP + thiamine diphosphate = AMP + thiamine triphosphate; Xref=Rhea:RHEA:69180, ChEBI:CHEBI:58937, ChEBI:CHEBI:58938, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00034400}; CATALYTIC ACTIVITY: Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence={ECO:0000256|HAMAP-Rule:MF_03171}; CATALYTIC ACTIVITY: Reaction=ATP + GDP = ADP + GTP; Xref=Rhea:RHEA:27686, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034442}; CATALYTIC ACTIVITY: Reaction=ATP + UDP = ADP + UTP; Xref=Rhea:RHEA:25098, ChEBI:CHEBI:30616, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034451}; CATALYTIC ACTIVITY: Reaction=ATP + dGDP = ADP + dGTP; Xref=Rhea:RHEA:27690, ChEBI:CHEBI:30616, ChEBI:CHEBI:58595, ChEBI:CHEBI:61429, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034407}; CATALYTIC ACTIVITY: Reaction=ATP + dTDP = ADP + dTTP; Xref=Rhea:RHEA:27682, ChEBI:CHEBI:30616, ChEBI:CHEBI:37568, ChEBI:CHEBI:58369, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034432}; CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|HAMAP-Rule:MF_03171}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|HAMAP-Rule:MF_03171}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; Evidence={ECO:0000256|ARBA:ARBA00034410};

ATP-binding;Cytoplasm;Kinase;Nucleotide-binding;Reference proteome;Transferase

ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; outer dense fiber [GO:0001520]

adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside triphosphate adenylate kinase activity [GO:0046899]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_03171}.

DOMAIN: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. {ECO:0000256|HAMAP-Rule:MF_03171}.

IPR000850;IPR033690;IPR028582;IPR006267;IPR027417;

3.40.50.300;

A0A2I2YTG6

MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLTVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIQVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCHTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKPDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFATNLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFHLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKTPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADMRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDTISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKKIKAILQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDTLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.1

COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

ATP-binding;DNA damage;DNA repair;DNA-binding;Kinase;Manganese;Nucleotide-binding;Reference proteome;Transferase

cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; establishment of RNA localization to telomere [GO:0097694]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of DNA replication [GO:0008156]; nuclear membrane disassembly [GO:0051081]; phosphorylation [GO:0016310]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; protein localization to chromosome, telomeric region [GO:0070198]; replicative senescence [GO:0090399]; response to mechanical stimulus [GO:0009612]; telomere maintenance [GO:0000723]

ATR-ATRIP complex [GO:0070310]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; PML body [GO:0016605]; site of DNA damage [GO:0090734]

ATP binding [GO:0005524]; DNA binding [GO:0003677]; histone H2AXS139 kinase activity [GO:0035979]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein serine/threonine kinase activity [GO:0004674]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR011989;IPR016024;IPR003152;IPR021133;IPR011009;IPR000403;IPR036940;IPR018936;IPR003151;IPR014009;IPR011990;IPR012993;

1.25.10.10;1.10.1070.11;1.25.40.10;

A0A2I2YTU5

MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDNPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDEETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEVYHEGECSALFEASGTTTQAYRVDERAAEQARWEEASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. {ECO:0000256|PIRNR:PIRNR037880}.

2.3.2.31

CATALYTIC ACTIVITY: Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.; EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798, ECO:0000256|PIRNR:PIRNR037880};

PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|PIRNR:PIRNR037880}.

Autophagy;Cytoplasm;Metal-binding;Mitochondrion;Phosphoprotein;Reference proteome;Repeat;Transferase;Ubl conjugation;Ubl conjugation pathway;Zinc;Zinc-finger

adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; cellular response to toxic substance [GO:0097237]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; free ubiquitin chain polymerization [GO:0010994]; learning [GO:0007612]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of transcription by RNA polymerase II [GO:0000122]; norepinephrine metabolic process [GO:0042415]; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitophagy [GO:1901526]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation protein catabolic process at presynapse [GO:0140251]; response to endoplasmic reticulum stress [GO:0034976]; startle response [GO:0001964]; synaptic transmission, glutamatergic [GO:0035249]; ubiquitin-dependent protein catabolic process [GO:0006511]

aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; ubiquitin ligase complex [GO:0000151]

actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|PIRNR:PIRNR037880}.

IPR047534;IPR031127;IPR002867;IPR003977;IPR041565;IPR047536;IPR047535;IPR044066;IPR000626;IPR029071;IPR041170;

1.20.120.1750;2.20.25.20;

A0A2I2YWA2

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAVRTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.5.2

CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000256|ARBA:ARBA00023421};

GTP-binding;Membrane;Nucleotide-binding;Reference proteome

adipose tissue development [GO:0060612]; cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; defense response to protozoan [GO:0042832]; endocytosis [GO:0006897]; fibroblast proliferation [GO:0048144]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway [GO:0097193]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; oncogene-induced cell senescence [GO:0090402]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of JNK cascade [GO:0046330]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; positive regulation of wound healing [GO:0090303]; Ras protein signal transduction [GO:0007265]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; Schwann cell development [GO:0014044]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]

cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; GTPase complex [GO:1905360]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]

GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-membrane adaptor activity [GO:0043495]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00037794}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037794}. Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004423}.

IPR027417;IPR005225;IPR001806;IPR020849;

3.40.50.300;

A0A2I2YY32

MASSLQRPWRVPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQAANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.30

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

ATP-binding;Kinase;Magnesium;Manganese;Membrane;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Signal;Transferase;Transmembrane;Transmembrane helix

anterior/posterior pattern specification [GO:0009952]; aortic valve development [GO:0003176]; atrial septum morphogenesis [GO:0060413]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endocardial cushion development [GO:0003197]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lung vasculature development [GO:0060426]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of bone mineralization [GO:0030501]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve development [GO:0003177]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; tricuspid valve morphogenesis [GO:0003186]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412]

adherens junction [GO:0005912]; axon [GO:0030424]; caveola [GO:0005901]; cell body [GO:0044297]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; receptor complex [GO:0043235]

activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; BMP binding [GO:0036122]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; protein tyrosine kinase binding [GO:1990782]; transforming growth factor beta receptor activity [GO:0005024]

IPR000472;IPR011009;IPR000719;IPR017441;IPR045860;IPR000333;

2.10.60.10;1.10.510.10;

A0A2I2YYZ4

MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEELQVLQPRNIAKRHDEGHKRPRDLQASSGGNRGGMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVVVESMHAGATWCYLLLFFLFFLLSSLPESRSKDTV

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. {ECO:0000256|PIRNR:PIRNR036665}.

3.1.6.-

CATALYTIC ACTIVITY: Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; EC=3.1.6.14; Evidence={ECO:0000256|ARBA:ARBA00034997}; CATALYTIC ACTIVITY: Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence={ECO:0000256|ARBA:ARBA00034984};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR036665-52}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR036665-52};

Calcium;Coiled coil;Endoplasmic reticulum;Golgi apparatus;Hydrolase;Membrane;Metal-binding;Reference proteome;Signal;Transmembrane;Transmembrane helix

bone development [GO:0060348]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of prostatic bud formation [GO:0060686]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]

arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]

SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR036665}. Golgi apparatus, Golgi stack {ECO:0000256|ARBA:ARBA00004348, ECO:0000256|PIRNR:PIRNR036665}. Cell surface {ECO:0000256|PIRNR:PIRNR036665}.

PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000256|PIRSR:PIRSR036665-50}.

IPR017850;IPR014615;IPR024609;IPR024607;IPR000917;

3.40.720.10;

A0A2I2YZ17

MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQADWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEVSESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171, ECO:0000256|RuleBase:RU000312};

ATP-binding;Developmental protein;Differentiation;Disulfide bond;Glycoprotein;Immunoglobulin domain;Kinase;Leucine-rich repeat;Membrane;Neurogenesis;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; behavioral response to formalin induced pain [GO:0061368]; cellular response to nerve growth factor stimulus [GO:1990090]; circadian rhythm [GO:0007623]; mechanoreceptor differentiation [GO:0042490]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; nerve growth factor signaling pathway [GO:0038180]; neuron apoptotic process [GO:0051402]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; sympathetic nervous system development [GO:0048485]

axon [GO:0030424]; cell surface [GO:0009986]; early endosome [GO:0005769]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]

ATP binding [GO:0005524]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotrophin binding [GO:0043121]; neurotrophin receptor activity [GO:0005030]; protein homodimerization activity [GO:0042803]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR000483;IPR007110;IPR036179;IPR013783;IPR003599;IPR011009;IPR001611;IPR032675;IPR020777;IPR020461;IPR031635;IPR000719;IPR017441;IPR001245;IPR040665;IPR008266;IPR020635;IPR002011;

2.60.40.10;3.80.10.10;1.10.510.10;

A0A2I2YZW1

MHVTAPGGAPSVNAAAVPLPKPAASAGPRGPMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.24

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000494}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000088, ECO:0000256|RuleBase:RU361165};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|RuleBase:RU361165};

ATP-binding;Kinase;Magnesium;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

androgen receptor signaling pathway [GO:0030521]; B cell receptor signaling pathway [GO:0050853]; Bergmann glial cell differentiation [GO:0060020]; cardiac neural crest cell development involved in heart development [GO:0061308]; caveolin-mediated endocytosis [GO:0072584]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cytosine metabolic process [GO:0019858]; DNA damage response [GO:0006974]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intracellular signal transduction [GO:0035556]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; long-term synaptic potentiation [GO:0060291]; lung morphogenesis [GO:0060425]; mammary gland epithelial cell proliferation [GO:0033598]; myelination [GO:0042552]; negative regulation of cell differentiation [GO:0045596]; outer ear morphogenesis [GO:0042473]; phosphorylation [GO:0016310]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage proliferation [GO:0120041]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; progesterone receptor signaling pathway [GO:0050847]; regulation of cellular pH [GO:0030641]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of ossification [GO:0030278]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; response to nicotine [GO:0035094]; Schwann cell development [GO:0014044]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]

caveola [GO:0005901]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pseudopodium [GO:0031143]; spindle [GO:0005819]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; phosphotyrosine residue binding [GO:0001784]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]

SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004345}.

IPR011009;IPR003527;IPR008349;IPR000719;IPR017441;IPR008271;

1.10.510.10;

A0A2I2Z075

MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILAAIAADLCKSEFNVYSQEVLTVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKRRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKKYQAVLRRKALLIFLVVHRLRWSSKQR

Gorilla gorilla gorilla (Western lowland gorilla)

CATALYTIC ACTIVITY: Reaction=(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:36135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17585, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:72745; Evidence={ECO:0000256|ARBA:ARBA00035777}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH; Xref=Rhea:RHEA:24216, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15894, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83276; EC=1.2.1.94; Evidence={ECO:0000256|ARBA:ARBA00036228}; CATALYTIC ACTIVITY: Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00035953}; CATALYTIC ACTIVITY: Reaction=2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:44016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:49189, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77268; Evidence={ECO:0000256|ARBA:ARBA00035974}; CATALYTIC ACTIVITY: Reaction=22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39015, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76298, ChEBI:CHEBI:76299; Evidence={ECO:0000256|ARBA:ARBA00036932}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate; Xref=Rhea:RHEA:44020, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17034, ChEBI:CHEBI:25629, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00035984}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00000589}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate; Xref=Rhea:RHEA:44172, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84067; Evidence={ECO:0000256|ARBA:ARBA00035786}; CATALYTIC ACTIVITY: Reaction=H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH; Xref=Rhea:RHEA:44108, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32362, ChEBI:CHEBI:34787, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036881}; CATALYTIC ACTIVITY: Reaction=a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH; Xref=Rhea:RHEA:49832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:35746, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036717}; CATALYTIC ACTIVITY: Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00024149}; CATALYTIC ACTIVITY: Reaction=decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:44104, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:31457, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036332}; CATALYTIC ACTIVITY: Reaction=dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+); Xref=Rhea:RHEA:44168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:27836, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036265};

Endoplasmic reticulum;Fatty acid metabolism;Lipid metabolism;Membrane;Microsome;NAD;Oxidoreductase;Reference proteome;Transmembrane;Transmembrane helix

cellular aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]

cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]

3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; long-chain-alcohol oxidase activity [GO:0046577]; long-chain-aldehyde dehydrogenase activity [GO:0050061]; medium-chain-aldehyde dehydrogenase activity [GO:0052814]; protein homodimerization activity [GO:0042803]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}.

IPR016161;IPR016163;IPR016160;IPR029510;IPR016162;IPR015590;IPR012394;

A0A2I2Z161

MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMDQNVPTEEQRANKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQPETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDKQGHKNLKTSQEGSSDDAERKQERENFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEESFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSEIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKTSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYCREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPPMRSKNPGPSQGKSM

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.4.12

CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00001665};

ATP-binding;Chromosome;DNA damage;DNA repair;DNA-binding;Hydrolase;Metal-binding;Nucleotide-binding;Nucleus;Reference proteome;Telomere;Zinc;Zinc-finger

cellular response to hydroxyurea [GO:0072711]; chromatin remodeling [GO:0006338]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]; transcription by RNA polymerase II [GO:0006366]

chromosome, subtelomeric region [GO:0099115]; condensed chromosome, centromeric region [GO:0000779]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]

ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin DNA binding [GO:0031490]; chromo shadow domain binding [GO:0070087]; DNA translocase activity [GO:0015616]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]

SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR025766;IPR041430;IPR014001;IPR001650;IPR027417;IPR038718;IPR049730;IPR000330;IPR011011;IPR013083;

3.40.50.300;1.20.120.850;3.40.50.10810;3.30.40.10;

A0A2I2Z1P5

MGREELFLTFSFSSGFQESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQITFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVSSNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQRILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.1.5

CATALYTIC ACTIVITY: Reaction=2 H2O + ITP = 2 H(+) + IMP + 2 phosphate; Xref=Rhea:RHEA:77735, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; Evidence={ECO:0000256|ARBA:ARBA00043682}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77736; Evidence={ECO:0000256|ARBA:ARBA00043682}; CATALYTIC ACTIVITY: Reaction=2 H2O + UTP = 2 H(+) + 2 phosphate + UMP; Xref=Rhea:RHEA:64896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:57865; Evidence={ECO:0000256|ARBA:ARBA00043678}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64897; Evidence={ECO:0000256|ARBA:ARBA00043678}; CATALYTIC ACTIVITY: Reaction=ADP + H2O = AMP + H(+) + phosphate; Xref=Rhea:RHEA:61436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036139}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61437; Evidence={ECO:0000256|ARBA:ARBA00036139}; CATALYTIC ACTIVITY: Reaction=ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:20988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00043702}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20989; Evidence={ECO:0000256|ARBA:ARBA00043702}; CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00034440}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000256|ARBA:ARBA00034440}; CATALYTIC ACTIVITY: Reaction=CDP + H2O = CMP + H(+) + phosphate; Xref=Rhea:RHEA:64880, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00043676}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64881; Evidence={ECO:0000256|ARBA:ARBA00043676}; CATALYTIC ACTIVITY: Reaction=CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:64908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00043680}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64909; Evidence={ECO:0000256|ARBA:ARBA00043680}; CATALYTIC ACTIVITY: Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence={ECO:0000256|ARBA:ARBA00043776}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; Evidence={ECO:0000256|ARBA:ARBA00043776}; CATALYTIC ACTIVITY: Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; Evidence={ECO:0000256|ARBA:ARBA00043654}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence={ECO:0000256|ARBA:ARBA00043654}; CATALYTIC ACTIVITY: Reaction=GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:64904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115; Evidence={ECO:0000256|ARBA:ARBA00043766}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64905; Evidence={ECO:0000256|ARBA:ARBA00043766}; CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000256|ARBA:ARBA00001702}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00001702}; CATALYTIC ACTIVITY: Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; Evidence={ECO:0000256|ARBA:ARBA00043688}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; Evidence={ECO:0000256|ARBA:ARBA00043688}; CATALYTIC ACTIVITY: Reaction=H2O + ITP = H(+) + IDP + phosphate; Xref=Rhea:RHEA:28330, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; Evidence={ECO:0000256|ARBA:ARBA00043752}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28331; Evidence={ECO:0000256|ARBA:ARBA00043752}; CATALYTIC ACTIVITY: Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; Evidence={ECO:0000256|ARBA:ARBA00043716}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; Evidence={ECO:0000256|ARBA:ARBA00043716}; CATALYTIC ACTIVITY: Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence={ECO:0000256|ARBA:ARBA00043661}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64901; Evidence={ECO:0000256|ARBA:ARBA00043661}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; Evidence={ECO:0000256|ARBA:ARBA00043714}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; Evidence={ECO:0000256|ARBA:ARBA00043714}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; Evidence={ECO:0000256|ARBA:ARBA00043753}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36796; Evidence={ECO:0000256|ARBA:ARBA00043753}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; Evidence={ECO:0000256|ARBA:ARBA00043686}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence={ECO:0000256|ARBA:ARBA00043686};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00001913}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

ATP-binding;Calcium;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Nucleotide-binding;Reference proteome;Transmembrane;Transmembrane helix

nucleoside diphosphate catabolic process [GO:0009134]; platelet aggregation [GO:0070527]

caveola [GO:0005901]; plasma membrane [GO:0005886]

ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR000407;

3.30.420.40;3.30.420.150;

A0A2I2Z1W9

MNCTLNKLKDLLSQISLLCPLVRIFCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIIRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDGPSHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

cell-cell adhesion [GO:0098609]; cellular response to cadmium ion [GO:0071276]; cellular response to estradiol stimulus [GO:0071392]; cellular response to reactive oxygen species [GO:0034614]; ERBB2-EGFR signaling pathway [GO:0038134]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiocyte differentiation [GO:1905208]; negative regulation of protein catabolic process [GO:0042177]; neurogenesis [GO:0022008]; phosphorylation [GO:0016310]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of JNK cascade [GO:0046328]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to UV-A [GO:0070141]

basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell surface [GO:0009986]; early endosome membrane [GO:0031901]; membrane raft [GO:0045121]; multivesicular body, internal vesicle lumen [GO:0097489]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]

actin filament binding [GO:0051015]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; epidermal growth factor binding [GO:0048408]; epidermal growth factor receptor activity [GO:0005006]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activator activity [GO:0030296]; ubiquitin protein ligase binding [GO:0031625]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR006211;IPR006212;IPR032778;IPR009030;IPR011009;IPR000719;IPR017441;IPR000494;IPR036941;IPR001245;IPR049328;IPR008266;IPR020635;IPR016245;

1.20.5.420;3.80.20.20;1.10.510.10;

A0A2I2Z1X0

MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTVSNSSEEHITQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKPSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKSSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSLPVMTVDYSKTVVKEPVDTRVSCCKTKDSEIYCTSNDSNPSLCNSEAENTELSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFENIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNHLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDIPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTHDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDREEEENWDQRDGSHFSDQSNKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTETDTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESNDTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGLRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE

Gorilla gorilla gorilla (Western lowland gorilla)

2.1.1.359

CATALYTIC ACTIVITY: Reaction=L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60324, Rhea:RHEA-COMP:9785, Rhea:RHEA-COMP:15536, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.359; Evidence={ECO:0000256|ARBA:ARBA00000317};

Chromatin regulator;Chromosome;Methyltransferase;Nucleus;Reference proteome;S-adenosyl-L-methionine;Transcription;Transcription regulation;Transferase

angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; defense response to virus [GO:0051607]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; endodermal cell differentiation [GO:0035987]; forebrain development [GO:0030900]; mesoderm morphogenesis [GO:0048332]; methylation [GO:0032259]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; pericardium development [GO:0060039]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to type I interferon [GO:0034340]; stem cell development [GO:0048864]; transcription elongation by RNA polymerase II [GO:0006368]

chromosome [GO:0005694]; nucleus [GO:0005634]

alpha-tubulin binding [GO:0043014]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]

SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR006560;IPR009078;IPR003616;IPR001214;IPR046341;IPR044437;IPR042294;IPR013257;IPR038190;IPR035441;IPR001202;IPR036020;

2.20.70.10;1.20.930.10;2.170.270.10;1.10.1740.100;

A0A2I2Z234

SRTNHGETHTVIPLFFFPSFLSFADEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.30

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023945}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023948, ECO:0000256|RuleBase:RU361271};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU361271}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|RuleBase:RU361271};

ATP-binding;Kinase;Magnesium;Manganese;Membrane;Metal-binding;Nucleotide-binding;Receptor;Reference proteome;Serine/threonine-protein kinase;Signal;Transferase;Transmembrane;Transmembrane helix

acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; BMP signaling pathway [GO:0030509]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endocardial cushion formation [GO:0003272]; endocardial cushion fusion [GO:0003274]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neural crest cell migration [GO:0001755]; pharyngeal system development [GO:0060037]; phosphorylation [GO:0016310]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular septum morphogenesis [GO:0060412]

activin receptor complex [GO:0048179]; apical part of cell [GO:0045177]; BMP receptor complex [GO:0070724]; plasma membrane [GO:0005886]

activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein tyrosine kinase binding [GO:1990782]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity, type I [GO:0005025]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.

IPR000472;IPR003605;IPR011009;IPR000719;IPR017441;IPR001245;IPR008271;IPR045860;IPR000333;

2.10.60.10;1.10.510.10;

A0A2I2Z314

MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHEDLNFLTRSQRYEVAVRKSAIMVKKMREFGIADPDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAEQQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTEPQITQVNQRVKELLTLIRSDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSPLNKAEVHESYKHLKSLQSKL

Gorilla gorilla gorilla (Western lowland gorilla)

CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2; Xref=Rhea:RHEA:69643, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:73862, ChEBI:CHEBI:187901; Evidence={ECO:0000256|ARBA:ARBA00036444}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69644; Evidence={ECO:0000256|ARBA:ARBA00036444}; CATALYTIC ACTIVITY: Reaction=(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2; Xref=Rhea:RHEA:39119, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:74086, ChEBI:CHEBI:76360; Evidence={ECO:0000256|ARBA:ARBA00036338}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39120; Evidence={ECO:0000256|ARBA:ARBA00036338}; CATALYTIC ACTIVITY: Reaction=O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2; Xref=Rhea:RHEA:38971, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57394, ChEBI:CHEBI:71412; Evidence={ECO:0000256|ARBA:ARBA00036774}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38972; Evidence={ECO:0000256|ARBA:ARBA00036774}; CATALYTIC ACTIVITY: Reaction=O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2; Xref=Rhea:RHEA:40175, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57386, ChEBI:CHEBI:62242; Evidence={ECO:0000256|ARBA:ARBA00036210}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40176; Evidence={ECO:0000256|ARBA:ARBA00036210}; CATALYTIC ACTIVITY: Reaction=O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2; Xref=Rhea:RHEA:40319, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:65052, ChEBI:CHEBI:74693; Evidence={ECO:0000256|ARBA:ARBA00036229}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40320; Evidence={ECO:0000256|ARBA:ARBA00036229}; CATALYTIC ACTIVITY: Reaction=O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40183, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57385, ChEBI:CHEBI:61405; Evidence={ECO:0000256|ARBA:ARBA00036028}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40184; Evidence={ECO:0000256|ARBA:ARBA00036028}; CATALYTIC ACTIVITY: Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2; Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6; Evidence={ECO:0000256|ARBA:ARBA00036397}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38960; Evidence={ECO:0000256|ARBA:ARBA00036397}; CATALYTIC ACTIVITY: Reaction=decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2; Xref=Rhea:RHEA:40179, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:61406, ChEBI:CHEBI:61430; Evidence={ECO:0000256|ARBA:ARBA00036151}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40180; Evidence={ECO:0000256|ARBA:ARBA00036151}; CATALYTIC ACTIVITY: Reaction=dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40171, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57330, ChEBI:CHEBI:57375; Evidence={ECO:0000256|ARBA:ARBA00036791}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40172; Evidence={ECO:0000256|ARBA:ARBA00036791}; CATALYTIC ACTIVITY: Reaction=glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2; Xref=Rhea:RHEA:40315, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57353, ChEBI:CHEBI:57378; Evidence={ECO:0000256|ARBA:ARBA00036750}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40316; Evidence={ECO:0000256|ARBA:ARBA00036750}; CATALYTIC ACTIVITY: Reaction=hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2; Xref=Rhea:RHEA:40275, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:77075, ChEBI:CHEBI:77085; Evidence={ECO:0000256|ARBA:ARBA00036704}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40276; Evidence={ECO:0000256|ARBA:ARBA00036704}; CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2; Xref=Rhea:RHEA:40167, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57379, ChEBI:CHEBI:61526; Evidence={ECO:0000256|ARBA:ARBA00036893}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40168; Evidence={ECO:0000256|ARBA:ARBA00036893}; CATALYTIC ACTIVITY: Reaction=hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2; Xref=Rhea:RHEA:40311, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:62077, ChEBI:CHEBI:62620; Evidence={ECO:0000256|ARBA:ARBA00036399}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40312; Evidence={ECO:0000256|ARBA:ARBA00036399};

COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|ARBA:ARBA00001974};

PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000256|ARBA:ARBA00004846}.

Acetylation;FAD;Fatty acid metabolism;Flavoprotein;Lipid metabolism;Oxidoreductase;Peroxisome;Phosphoprotein;Reference proteome

ascaroside biosynthetic process [GO:1904070]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]

peroxisome [GO:0005777]

FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]

SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.

IPR034171;IPR029320;IPR006091;IPR046373;IPR012258;IPR002655;IPR036250;IPR037069;IPR009100;

1.10.540.10;2.40.110.10;1.20.140.10;

A0A2I2Z667

MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Signal;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

cardiac muscle tissue regeneration [GO:0061026]; cell fate commitment [GO:0045165]; cellular response to epidermal growth factor stimulus [GO:0071364]; central nervous system morphogenesis [GO:0021551]; embryonic pattern specification [GO:0009880]; ERBB2-ERBB4 signaling pathway [GO:0038135]; ERBB4-ERBB4 signaling pathway [GO:0038138]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; heart development [GO:0007507]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell differentiation [GO:0060644]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell migration [GO:0001755]; neurogenesis [GO:0022008]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; olfactory bulb interneuron differentiation [GO:0021889]; phosphorylation [GO:0016310]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; receptor signaling pathway via JAK-STAT [GO:0007259]; regulation of cell migration [GO:0030334]; synapse assembly [GO:0007416]

basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]

ATP binding [GO:0005524]; epidermal growth factor receptor activity [GO:0005006]; epidermal growth factor receptor binding [GO:0005154]; GABA receptor binding [GO:0050811]; neuregulin receptor activity [GO:0038131]; protein homodimerization activity [GO:0042803]; transcription cis-regulatory region binding [GO:0000976]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR006211;IPR006212;IPR032778;IPR009030;IPR011009;IPR000719;IPR017441;IPR000494;IPR036941;IPR001245;IPR049328;IPR008266;IPR020635;IPR016245;

6.10.250.880;3.80.20.20;1.10.510.10;

A0A2I2Z719

MGRRSRGRRLQQQQRPEDAEDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPQLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADRTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLGEKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANSPDVTASCDPAGVHPPR

Gorilla gorilla gorilla (Western lowland gorilla)

2.1.1.203

CATALYTIC ACTIVITY: Reaction=a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61464, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15826, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00000377}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61465; Evidence={ECO:0000256|ARBA:ARBA00000377}; CATALYTIC ACTIVITY: Reaction=cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42940, Rhea:RHEA-COMP:10291, Rhea:RHEA-COMP:10295, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; EC=2.1.1.203; Evidence={ECO:0000256|ARBA:ARBA00001128}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42941; Evidence={ECO:0000256|ARBA:ARBA00001128}; CATALYTIC ACTIVITY: Reaction=cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42948, Rhea:RHEA-COMP:10293, Rhea:RHEA-COMP:10297, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00001405}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42949; Evidence={ECO:0000256|ARBA:ARBA00001405}; CATALYTIC ACTIVITY: Reaction=cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42952, Rhea:RHEA-COMP:10294, Rhea:RHEA-COMP:10385, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00000276}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42953; Evidence={ECO:0000256|ARBA:ARBA00000276}; CATALYTIC ACTIVITY: Reaction=cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:61488, Rhea:RHEA-COMP:15838, Rhea:RHEA-COMP:15839, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74483, ChEBI:CHEBI:82748; Evidence={ECO:0000256|ARBA:ARBA00001828}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61489; Evidence={ECO:0000256|ARBA:ARBA00001828};

Methyltransferase;Nucleus;Phosphoprotein;Reference proteome;RNA-binding;S-adenosyl-L-methionine;Transferase;tRNA processing;tRNA-binding

hair follicle maturation [GO:0048820]; in utero embryonic development [GO:0001701]; meiotic cell cycle checkpoint signaling [GO:0033313]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA stabilization [GO:0036416]

chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]

mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; tRNA (cytidine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]

SUBCELLULAR LOCATION: Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.

IPR049560;IPR001678;IPR023267;IPR023270;IPR029063;

3.40.50.150;

A0A2I2Z7B3

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVFIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000256|ARBA:ARBA00003917, ECO:0000256|RuleBase:RU000393}.

1.15.1.1

CATALYTIC ACTIVITY: Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; Evidence={ECO:0000256|RuleBase:RU000393};

COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000256|RuleBase:RU000393}; Note=Binds 1 copper ion per subunit. {ECO:0000256|RuleBase:RU000393}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|RuleBase:RU000393}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU000393};

Copper;Lipoprotein;Metal-binding;Oxidoreductase;Palmitate;Reference proteome;Zinc

action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; regulation of blood pressure [GO:0008217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]

axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]

copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]

IPR036423;IPR024134;IPR018152;IPR001424;

2.60.40.200;

A0A2I2Z7Q4

MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGFGNCLWTYLVSAGATLGHPTCLLQGTSHPQTKPNCRTVLWVPFTFCLWLSLSLPQHINPVAASLIQKMLQTDPTARPTVNELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAMTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.21

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence={ECO:0000256|ARBA:ARBA00000540}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.21; Evidence={ECO:0000256|ARBA:ARBA00000856, ECO:0000256|RuleBase:RU361162};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

centrosome cycle [GO:0007098]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; establishment of mitotic spindle orientation [GO:0000132]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; homologous chromosome segregation [GO:0045143]; microtubule bundle formation [GO:0001578]; mitotic cytokinesis [GO:0000281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear membrane disassembly [GO:0051081]; phosphorylation [GO:0016310]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein localization to nuclear envelope [GO:0090435]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization to cell cortex [GO:1904776]; synaptonemal complex disassembly [GO:0070194]

centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synaptonemal complex [GO:0000795]

anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR033701;IPR033695;IPR000959;IPR036947;IPR000719;IPR017441;IPR008271;

3.30.1120.30;1.10.510.10;

A0A2I2Z7U9

MASNPERGEILLTDLQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNELPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDTPGQDSEAVFDIENDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000946}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569};

ATP-binding;Coiled coil;Cytoplasm;Kinase;Nucleotide-binding;Nucleus;Phosphoprotein;Reference proteome;Repeat;Serine/threonine-protein kinase;Transcription;Transcription regulation;Transferase

apical junction assembly [GO:0043297]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; regulation of cell motility [GO:2000145]

apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]

ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; histone deacetylase binding [GO:0042826]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]

SUBCELLULAR LOCATION: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Midbody {ECO:0000256|ARBA:ARBA00004214}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR000961;IPR000008;IPR035892;IPR037784;IPR011072;IPR036274;IPR011009;IPR017892;IPR037313;IPR000719;IPR017441;IPR008271;

2.60.40.150;1.10.287.160;1.10.510.10;

A0A2I2Z829

MPSPRRSIEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLLTSRATGVDPTCARLRASESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.1.68

CATALYTIC ACTIVITY: Reaction=(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:47944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58057, ChEBI:CHEBI:88107; EC=3.6.1.68; Evidence={ECO:0000256|ARBA:ARBA00035809}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47945; Evidence={ECO:0000256|ARBA:ARBA00035809}; CATALYTIC ACTIVITY: Reaction=(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate; Xref=Rhea:RHEA:68020, ChEBI:CHEBI:15377, ChEBI:CHEBI:17447, ChEBI:CHEBI:43474, ChEBI:CHEBI:88107; Evidence={ECO:0000256|ARBA:ARBA00036169}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68021; Evidence={ECO:0000256|ARBA:ARBA00036169}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:48128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226, ChEBI:CHEBI:175763; Evidence={ECO:0000256|ARBA:ARBA00037020}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48129; Evidence={ECO:0000256|ARBA:ARBA00037020}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate; Xref=Rhea:RHEA:48132, ChEBI:CHEBI:15377, ChEBI:CHEBI:16619, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226; Evidence={ECO:0000256|ARBA:ARBA00036036}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48133; Evidence={ECO:0000256|ARBA:ARBA00036036}; CATALYTIC ACTIVITY: Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:68008, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58756, ChEBI:CHEBI:144936; Evidence={ECO:0000256|ARBA:ARBA00035926}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68009; Evidence={ECO:0000256|ARBA:ARBA00035926}; CATALYTIC ACTIVITY: Reaction=(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate; Xref=Rhea:RHEA:68016, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46762, ChEBI:CHEBI:144936; Evidence={ECO:0000256|ARBA:ARBA00036255}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68017; Evidence={ECO:0000256|ARBA:ARBA00036255}; CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000256|ARBA:ARBA00001611}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence={ECO:0000256|ARBA:ARBA00001611}; CATALYTIC ACTIVITY: Reaction=H2O + presqualene diphosphate = H(+) + phosphate + presqualene phosphate; Xref=Rhea:RHEA:67968, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57310, ChEBI:CHEBI:176803; Evidence={ECO:0000256|ARBA:ARBA00036000}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67969; Evidence={ECO:0000256|ARBA:ARBA00036000}; CATALYTIC ACTIVITY: Reaction=H2O + presqualene phosphate = phosphate + presqualene alcohol; Xref=Rhea:RHEA:68024, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:176803, ChEBI:CHEBI:176962; Evidence={ECO:0000256|ARBA:ARBA00035802}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68025; Evidence={ECO:0000256|ARBA:ARBA00035802};

Hydrolase;Lipid metabolism;Membrane;Nucleus;Reference proteome;Transmembrane;Transmembrane helix

farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]

endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]

isoprenoid diphosphate phosphatase activity [GO:0106405]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004370}. Nucleus envelope {ECO:0000256|ARBA:ARBA00004259}. Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004540}.

IPR036938;IPR000326;

1.20.144.10;

A0A2I2Z963

MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTPL

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000256|PIRNR:PIRNR000956}.

3.1.4.11

CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence={ECO:0000256|ARBA:ARBA00023726}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43485; Evidence={ECO:0000256|ARBA:ARBA00023726}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence={ECO:0000256|ARBA:ARBA00023674}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33180; Evidence={ECO:0000256|ARBA:ARBA00023674};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR000956-2}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000956-2};

Calcium;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Phosphoprotein;Reference proteome;Transducer

activation of meiosis involved in egg activation [GO:0060466]; cerebral cortex development [GO:0021987]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; G2/M transition of mitotic cell cycle [GO:0000086]; glutamate receptor signaling pathway [GO:0007215]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-15-mediated signaling pathway [GO:0035723]; ion channel modulating, G protein-coupled receptor signaling pathway [GO:0099105]; ligand-gated ion channel signaling pathway [GO:1990806]; lipid catabolic process [GO:0016042]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of monocyte extravasation [GO:2000438]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of CD24 production [GO:2000560]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of myoblast differentiation [GO:0045663]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of fertilization [GO:0080154]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; release of sequestered calcium ion into cytosol [GO:0051209]

chromatin [GO:0000785]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; nuclear speck [GO:0016607]; postsynaptic cytosol [GO:0099524]

calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]; lamin binding [GO:0005521]; phosphatidylinositol phospholipase C activity [GO:0004435]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]

IPR000008;IPR035892;IPR011992;IPR001192;IPR016280;IPR028400;IPR014815;IPR042531;IPR009535;IPR037862;IPR017946;IPR015359;IPR000909;IPR001711;

2.30.29.240;2.60.40.150;1.10.238.10;3.20.20.190;1.20.1230.10;

A0A2I2Z9G0

MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFRHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNMQVFEFQLTSEDMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY

Gorilla gorilla gorilla (Western lowland gorilla)

CATALYTIC ACTIVITY: Reaction=(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH; Xref=Rhea:RHEA:16729, ChEBI:CHEBI:10702, ChEBI:CHEBI:15378, ChEBI:CHEBI:18135, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.20; Evidence={ECO:0000256|ARBA:ARBA00036133}; CATALYTIC ACTIVITY: Reaction=(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone; Xref=Rhea:RHEA:42108, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28453, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00023933}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42109; Evidence={ECO:0000256|ARBA:ARBA00023933}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42110; Evidence={ECO:0000256|ARBA:ARBA00023933}; CATALYTIC ACTIVITY: Reaction=(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone; Xref=Rhea:RHEA:42112, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000256|ARBA:ARBA00023980}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42113; Evidence={ECO:0000256|ARBA:ARBA00023980}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42114; Evidence={ECO:0000256|ARBA:ARBA00023980}; CATALYTIC ACTIVITY: Reaction=(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH; Xref=Rhea:RHEA:16317, ChEBI:CHEBI:15378, ChEBI:CHEBI:17404, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:156384; EC=1.1.1.112; Evidence={ECO:0000256|ARBA:ARBA00036985}; CATALYTIC ACTIVITY: Reaction=(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH; Xref=Rhea:RHEA:16321, ChEBI:CHEBI:15378, ChEBI:CHEBI:17404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:156384; EC=1.1.1.112; Evidence={ECO:0000256|ARBA:ARBA00036983}; CATALYTIC ACTIVITY: Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence={ECO:0000256|ARBA:ARBA00023927}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence={ECO:0000256|ARBA:ARBA00023927}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24614; Evidence={ECO:0000256|ARBA:ARBA00023927}; CATALYTIC ACTIVITY: Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence={ECO:0000256|ARBA:ARBA00023984}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24617; Evidence={ECO:0000256|ARBA:ARBA00023984}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24618; Evidence={ECO:0000256|ARBA:ARBA00023984}; CATALYTIC ACTIVITY: Reaction=a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH; Xref=Rhea:RHEA:34779, ChEBI:CHEBI:15378, ChEBI:CHEBI:36835, ChEBI:CHEBI:47788, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.357; Evidence={ECO:0000256|ARBA:ARBA00023972}; CATALYTIC ACTIVITY: Reaction=a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34783, ChEBI:CHEBI:15378, ChEBI:CHEBI:36835, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.357; Evidence={ECO:0000256|ARBA:ARBA00023921};

PATHWAY: Steroid metabolism. {ECO:0000256|ARBA:ARBA00004854}.

NADP;Reference proteome

cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]

cytosol [GO:0005829]

alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]

IPR020471;IPR044482;IPR018170;IPR023210;IPR036812;

3.20.20.100;

A0A2I2Z9P7

MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRMAAKRLKEGDTMMGQQVAKVVESKNAALPKGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEDTLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRAGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIVKA

Gorilla gorilla gorilla (Western lowland gorilla)

1.3.1.48; 1.3.1.74

CATALYTIC ACTIVITY: Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974, ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213; Evidence={ECO:0000256|ARBA:ARBA00023498}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590; Evidence={ECO:0000256|ARBA:ARBA00023548}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence={ECO:0000256|ARBA:ARBA00023544}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586; Evidence={ECO:0000256|ARBA:ARBA00023544}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence={ECO:0000256|ARBA:ARBA00023543}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594; Evidence={ECO:0000256|ARBA:ARBA00023543}; CATALYTIC ACTIVITY: Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208, ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133346; Evidence={ECO:0000256|ARBA:ARBA00023517}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209; Evidence={ECO:0000256|ARBA:ARBA00023517}; CATALYTIC ACTIVITY: Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112; Evidence={ECO:0000256|ARBA:ARBA00023553}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738; Evidence={ECO:0000256|ARBA:ARBA00023553}; CATALYTIC ACTIVITY: Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974; Evidence={ECO:0000256|ARBA:ARBA00023496}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205; Evidence={ECO:0000256|ARBA:ARBA00023496}; CATALYTIC ACTIVITY: Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; Evidence={ECO:0000256|ARBA:ARBA00023696}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618; Evidence={ECO:0000256|ARBA:ARBA00023696}; CATALYTIC ACTIVITY: Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH; Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748; Evidence={ECO:0000256|ARBA:ARBA00023504}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782; Evidence={ECO:0000256|ARBA:ARBA00023504}; CATALYTIC ACTIVITY: Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276; Evidence={ECO:0000256|ARBA:ARBA00024160}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790; Evidence={ECO:0000256|ARBA:ARBA00024160}; CATALYTIC ACTIVITY: Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; Evidence={ECO:0000256|ARBA:ARBA00023507}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739; Evidence={ECO:0000256|ARBA:ARBA00023507}; CATALYTIC ACTIVITY: Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH; Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455; Evidence={ECO:0000256|ARBA:ARBA00023691}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614; Evidence={ECO:0000256|ARBA:ARBA00023691}; CATALYTIC ACTIVITY: Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH; Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741; Evidence={ECO:0000256|ARBA:ARBA00023530}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786; Evidence={ECO:0000256|ARBA:ARBA00023530}; CATALYTIC ACTIVITY: Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence={ECO:0000256|ARBA:ARBA00034052}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778; Evidence={ECO:0000256|ARBA:ARBA00034052}; CATALYTIC ACTIVITY: Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309; Evidence={ECO:0000256|ARBA:ARBA00023545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609; Evidence={ECO:0000256|ARBA:ARBA00023545};

Fatty acid metabolism;Hydroxylation;Lipid metabolism;Oxidoreductase;Prostaglandin metabolism;Reference proteome

prostaglandin metabolic process [GO:0006693]

cytoplasm [GO:0005737]

13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; 2-alkenal reductase (NADP+) activity [GO:0035798]

IPR013149;IPR041694;IPR011032;IPR045010;IPR036291;IPR020843;IPR014190;

3.90.180.10;3.40.50.720;

A0A2I2ZA05

MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYKGGLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSTCHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK

Gorilla gorilla gorilla (Western lowland gorilla)

3.4.23.46

CATALYTIC ACTIVITY: Reaction=Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.; EC=3.4.23.46; Evidence={ECO:0000256|ARBA:ARBA00000187};

Acetylation;Aspartyl protease;Cell membrane;Cell projection;Cytoplasmic vesicle;Endoplasmic reticulum;Glycoprotein;Hydrolase;Isopeptide bond;Lipoprotein;Membrane;Palmitate;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Ubl conjugation;Zymogen

amyloid-beta formation [GO:0034205]; amyloid-beta metabolic process [GO:0050435]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of neuron apoptotic process [GO:0043525]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; signaling receptor ligand precursor processing [GO:0140448]

axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosome [GO:0005764]; membrane raft [GO:0045121]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]

amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase activity [GO:0004190]; enzyme binding [GO:0019899]

SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell surface {ECO:0000256|ARBA:ARBA00004241}. Early endosome {ECO:0000256|ARBA:ARBA00004412}. Endosome {ECO:0000256|ARBA:ARBA00004177}. Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}. Late endosome {ECO:0000256|ARBA:ARBA00004603}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Recycling endosome {ECO:0000256|ARBA:ARBA00004172}.

IPR001461;IPR001969;IPR009119;IPR009120;IPR033874;IPR033121;IPR021109;

2.40.70.10;

A0A2I2ZA61

MPKRGKKGAVAEDGDELKTGKGMKSLETTKPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSYQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. {ECO:0000256|RuleBase:RU362131}.

3.1.11.2; 3.1.21.-

CATALYTIC ACTIVITY: Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence={ECO:0000256|ARBA:ARBA00000493};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|PIRSR:PIRSR604808-2, ECO:0000256|RuleBase:RU362131}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|PIRSR:PIRSR604808-2, ECO:0000256|RuleBase:RU362131}; Note=Probably binds two magnesium or manganese ions per subunit. {ECO:0000256|PIRSR:PIRSR604808-2, ECO:0000256|RuleBase:RU362131}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

Cytoplasm;DNA damage;DNA recombination;DNA repair;DNA-binding;Endonuclease;Exonuclease;Hydrolase;Magnesium;Manganese;Metal-binding;Mitochondrion;Nuclease;Nucleus;Reference proteome;Repressor;S-nitrosylation;Transcription;Transcription regulation

base-excision repair [GO:0006284]; cell redox homeostasis [GO:0045454]; DNA catabolic process [GO:0006308]; DNA recombination [GO:0006310]; positive regulation of gene expression via CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488]; telomere maintenance via base-excision repair [GO:0097698]

centrosome [GO:0005813]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]

chromatin DNA binding [GO:0031490]; class II DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0052720]; DNA-(abasic site) binding [GO:0140431]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; double-stranded telomeric DNA binding [GO:0003691]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [GO:0090580]; phosphoric diester hydrolase activity [GO:0008081]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU362131}. Cytoplasm {ECO:0000256|RuleBase:RU362131}. Mitochondrion {ECO:0000256|RuleBase:RU362131}.

IPR004808;IPR020847;IPR020848;IPR036691;IPR005135;

3.60.10.10;

A0A2I2ZBB8

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.5.5

CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; Evidence={ECO:0000256|ARBA:ARBA00001837};

Biological rhythms;Coated pit;Cytoplasmic vesicle;Golgi apparatus;GTP-binding;Lipid-binding;Membrane;Mitochondrion;Mitochondrion outer membrane;Nucleotide-binding;Peroxisome;Reference proteome;Synapse

calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; membrane fusion [GO:0061025]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitocytosis [GO:0160040]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; regulation of ATP metabolic process [GO:1903578]; regulation of gene expression [GO:0010468]; regulation of mitophagy [GO:1901524]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]; rhythmic process [GO:0048511]

brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrion-derived vesicle [GO:0099073]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672]

GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004432}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004450}. Peroxisome {ECO:0000256|ARBA:ARBA00004275}.

IPR022812;IPR001401;IPR019762;IPR045063;IPR000375;IPR030381;IPR003130;IPR020850;IPR027417;

1.20.120.1240;3.40.50.300;

A0A2I2ZDW4

ILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGASDSLRTPEQGSNGTDGASQKAPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKNKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKATLSWSNGNGTASCRVLLESIGSHEELIQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLLGPVDPSSGQQSQDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAVEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNFNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLEWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKVGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGASAGFELEVSSGAWNNATHLESCSSENGTEYRTEVMYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSHSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA

Gorilla gorilla gorilla (Western lowland gorilla)

3.1.3.48

CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000256|ARBA:ARBA00001490};

Glycoprotein;Hydrolase;Membrane;Protein phosphatase;Reference proteome;Signal;Transmembrane;Transmembrane helix

B cell differentiation [GO:0030183]; blood coagulation [GO:0007596]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; dephosphorylation [GO:0016311]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; oligodendrocyte differentiation [GO:0048709]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive chemotaxis [GO:0050918]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of platelet activation [GO:0010572]; positive regulation of tumor necrosis factor production [GO:0032760]; vasculogenesis [GO:0001570]

cell surface [GO:0009986]; cell-cell junction [GO:0005911]; immunological synapse [GO:0001772]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]

beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; mitogen-activated protein kinase binding [GO:0051019]; platelet-derived growth factor receptor binding [GO:0005161]; protein tyrosine phosphatase activity [GO:0004725]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR003961;IPR036116;IPR013783;IPR029021;IPR000242;IPR041201;IPR016130;IPR003595;IPR000387;

2.60.40.10;3.90.190.10;

A0A2I2ZE50

MVKAPWTLKKHFVGNPTNSDFELKTAELPPLKNREVLLEALFLTGDPYMRVAAKRLKEGDTMMGQQVARFVESKNAALPTGTIVLAPSGWTVHSIADGKDLENLPTEWPDTVPLSLALGTVSMTGLTAYFGLLDICGVKGGETVMVNVAAGAVGSVLGQITKLKGCKVVGAVGSDEKTACLKKLGSDVFNYKTKASPDGYSCYFDNVSGWFSNTVISQMKKFGRIAICGAISIYITYTYLHITPVIPMYQELHMEGFIVTCWPGDAHQKALKDLLKWVSEGQIQYQEYIIEGYENMPAAFMGMLKGDNLGKTIVKA

Gorilla gorilla gorilla (Western lowland gorilla)

1.3.1.48; 1.3.1.74

CATALYTIC ACTIVITY: Reaction=(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51212, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133974, ChEBI:CHEBI:133975; Evidence={ECO:0000256|ARBA:ARBA00023498}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51213; Evidence={ECO:0000256|ARBA:ARBA00023498}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374, ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590; Evidence={ECO:0000256|ARBA:ARBA00023548}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133408; Evidence={ECO:0000256|ARBA:ARBA00023544}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586; Evidence={ECO:0000256|ARBA:ARBA00023544}; CATALYTIC ACTIVITY: Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:79072, ChEBI:CHEBI:133411; Evidence={ECO:0000256|ARBA:ARBA00023543}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594; Evidence={ECO:0000256|ARBA:ARBA00023543}; CATALYTIC ACTIVITY: Reaction=20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:51208, ChEBI:CHEBI:15378, ChEBI:CHEBI:57460, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133346; Evidence={ECO:0000256|ARBA:ARBA00023517}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51209; Evidence={ECO:0000256|ARBA:ARBA00023517}; CATALYTIC ACTIVITY: Reaction=4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:64736, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58968, ChEBI:CHEBI:156112; Evidence={ECO:0000256|ARBA:ARBA00023553}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64738; Evidence={ECO:0000256|ARBA:ARBA00023553}; CATALYTIC ACTIVITY: Reaction=6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH; Xref=Rhea:RHEA:51204, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:90723, ChEBI:CHEBI:133974; Evidence={ECO:0000256|ARBA:ARBA00023496}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51205; Evidence={ECO:0000256|ARBA:ARBA00023496}; CATALYTIC ACTIVITY: Reaction=NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:77927, ChEBI:CHEBI:133457; Evidence={ECO:0000256|ARBA:ARBA00023696}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50618; Evidence={ECO:0000256|ARBA:ARBA00023696}; CATALYTIC ACTIVITY: Reaction=NADP(+) + octanal = (2E)-octenal + H(+) + NADPH; Xref=Rhea:RHEA:50780, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:61748; Evidence={ECO:0000256|ARBA:ARBA00023504}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50782; Evidence={ECO:0000256|ARBA:ARBA00023504}; CATALYTIC ACTIVITY: Reaction=NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH; Xref=Rhea:RHEA:50788, ChEBI:CHEBI:15378, ChEBI:CHEBI:16472, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145276; Evidence={ECO:0000256|ARBA:ARBA00024160}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50790; Evidence={ECO:0000256|ARBA:ARBA00024160}; CATALYTIC ACTIVITY: Reaction=an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:13737, ChEBI:CHEBI:12834, ChEBI:CHEBI:13757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.74; Evidence={ECO:0000256|ARBA:ARBA00023507}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:13739; Evidence={ECO:0000256|ARBA:ARBA00023507}; CATALYTIC ACTIVITY: Reaction=decanal + NADP(+) = (2E)-decenal + H(+) + NADPH; Xref=Rhea:RHEA:50612, ChEBI:CHEBI:15378, ChEBI:CHEBI:31457, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133455; Evidence={ECO:0000256|ARBA:ARBA00023691}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50614; Evidence={ECO:0000256|ARBA:ARBA00023691}; CATALYTIC ACTIVITY: Reaction=dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH; Xref=Rhea:RHEA:50784, ChEBI:CHEBI:15378, ChEBI:CHEBI:27836, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133741; Evidence={ECO:0000256|ARBA:ARBA00023530}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50786; Evidence={ECO:0000256|ARBA:ARBA00023530}; CATALYTIC ACTIVITY: Reaction=hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH; Xref=Rhea:RHEA:50776, ChEBI:CHEBI:15378, ChEBI:CHEBI:28913, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:88528; Evidence={ECO:0000256|ARBA:ARBA00034052}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50778; Evidence={ECO:0000256|ARBA:ARBA00034052}; CATALYTIC ACTIVITY: Reaction=leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH; Xref=Rhea:RHEA:50608, ChEBI:CHEBI:15378, ChEBI:CHEBI:57461, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133309; Evidence={ECO:0000256|ARBA:ARBA00023545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50609; Evidence={ECO:0000256|ARBA:ARBA00023545};

Fatty acid metabolism;Hydroxylation;Lipid metabolism;Membrane;Oxidoreductase;Prostaglandin metabolism;Reference proteome;Transmembrane;Transmembrane helix

prostaglandin metabolic process [GO:0006693]

cytoplasm [GO:0005737]; membrane [GO:0016020]

13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; 2-alkenal reductase [NAD(P)+] activity [GO:0032440]

IPR013149;IPR041694;IPR011032;IPR045010;IPR036291;IPR020843;IPR014190;

3.90.180.10;3.40.50.720;

A0A2I2ZGA7

MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYGIPQDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVETDSLPADWAPLFTNANDGSNEGIVGSKSPVPLPTWSVQFHPEHQAGPSDMELLFDIFLETVKEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETVELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAAFEPSLDYCVVKIPRWDLSKFLRVSTEIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTMAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRGFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLGRF

Gorilla gorilla gorilla (Western lowland gorilla)

CATALYTIC ACTIVITY: Reaction=(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate; Xref=Rhea:RHEA:24296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30864, ChEBI:CHEBI:32814; EC=3.5.2.3; Evidence={ECO:0000256|ARBA:ARBA00000462}; CATALYTIC ACTIVITY: Reaction=2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate; Xref=Rhea:RHEA:18633, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.5.5; Evidence={ECO:0000256|ARBA:ARBA00001777}; CATALYTIC ACTIVITY: Reaction=2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate; Xref=Rhea:RHEA:18029, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=6.3.4.16; Evidence={ECO:0000256|ARBA:ARBA00043687}; CATALYTIC ACTIVITY: Reaction=H2O + L-glutamine = L-glutamate + NH4(+); Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2; Evidence={ECO:0000256|ARBA:ARBA00001062}; CATALYTIC ACTIVITY: Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228; EC=2.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00001363};

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947};

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. {ECO:0000256|ARBA:ARBA00005077}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. {ECO:0000256|ARBA:ARBA00004812}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. {ECO:0000256|ARBA:ARBA00004852}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. {ECO:0000256|ARBA:ARBA00004880}.

ATP-binding;Glutamine amidotransferase;Hydrolase;Ligase;Metal-binding;Multifunctional enzyme;Nucleotide-binding;Pyrimidine biosynthesis;Reference proteome;Repeat;Transferase

'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; citrulline biosynthetic process [GO:0019240]; glutamine metabolic process [GO:0006541]; UDP biosynthetic process [GO:0006225]; UTP biosynthetic process [GO:0006228]

carbamoyl-phosphate synthase complex [GO:0005951]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]

amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]

IPR006680;IPR006132;IPR006130;IPR036901;IPR002082;IPR006131;IPR011761;IPR013815;IPR006275;IPR005480;IPR036897;IPR006274;IPR002474;IPR036480;IPR005479;IPR005483;IPR029062;IPR035686;IPR002195;IPR017926;IPR011059;IPR032466;IPR011607;IPR036914;IPR016185;

3.40.50.20;3.40.50.880;3.40.50.1370;3.30.1490.20;3.30.470.20;3.50.30.20;1.10.1030.10;3.20.20.140;3.40.50.1380;

A0A2I2ZGC2

RELLSPDGLMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTHSQAPLLRWVLTLSFLVATVAVGLYAM

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000256|ARBA:ARBA00037361}.

1.14.14.18

CATALYTIC ACTIVITY: Reaction=heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21764, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:29033, ChEBI:CHEBI:57618, ChEBI:CHEBI:57991, ChEBI:CHEBI:58210, ChEBI:CHEBI:60344; EC=1.14.14.18; Evidence={ECO:0000256|ARBA:ARBA00036473}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21765; Evidence={ECO:0000256|ARBA:ARBA00036473};

Endoplasmic reticulum;Heme;Iron;Membrane;Metal-binding;Oxidoreductase;Reference proteome;Transmembrane;Transmembrane helix

cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to cisplatin [GO:0072719]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; epithelial cell apoptotic process [GO:1904019]; erythrocyte homeostasis [GO:0034101]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; intracellular iron ion homeostasis [GO:0006879]; macroautophagy [GO:0016236]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of macroautophagy [GO:0016242]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of macroautophagy [GO:0016239]; positive regulation of smooth muscle cell proliferation [GO:0048661]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; wound healing involved in inflammatory response [GO:0002246]

cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]

heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00037869}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037869}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037869}.

IPR002051;IPR016053;IPR016084;IPR018207;

1.20.910.10;

A0A2I2ZGP8

MAASFPPTLGLSSAPDEIQHPHIKFSEWKFKLFRVRSFEKTPEEAQKVKKDSFEGKPSLEQSPAVLDKADGQKPVPTQPLLKAHPKFSKKFHDNGKARGKAIHQANLRHLCRICGNSFRTDEHNRRYPVHGPVDGKTLGLLRKKEKRATSWPDLIAKVFRIDVKADVDSIHPTEFCHNCWSIMHRKFSSAPCEVYFPRNVTMEWHPHTPSCDICNTACRGLKRKSLQPNLQLSKKLKTVLDQARRARQRKRRAQARISSKDVMKKIANCSKIHLSTKLLAVDFPEHFVKSISCQICEHILADPVETNCKHVFCRVCILRCLKVMGSYCPSCRYPCFPTDLESPVKSFLSILNSLMVKCPAKECNEEVSLEKYNHHISSHKESKETFVHINKGGRPRQHLLSLTRRAQKHRLRELKLQVKAFADKEEGGDVKSVCMTLFLLALRARNEHRQADELEAIMQGKGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHALRNAEKVLLPGYHHFEWQPPLKNVSSSTDVGIIDGLSGLSSSVDDYPVDTIAKRFRYDSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKESCDGMGDVSEKHGSGPVVPEKAVRFSFTIMKITIAHSSQNVKVFEEAKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKSSELMLELGGILRTFRFIFRGTGYDEKLVREVEGLEASGSVYICTLCDATRLEASQNLVFHSITRSHAENLERYEVWRSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGNAAEFYKIFQLEIGEVYKNPNASKEERKRWQATLDKHLRKKMNLKPIMRMNGNFARKLMTKETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQYSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASEGNESGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNALKTSGFTMNPQASLGDPLGIEDSLESQDSMEF

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. {ECO:0000256|RuleBase:RU366024}.

2.3.2.27; 3.1.-.-

CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900, ECO:0000256|RuleBase:RU366024};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|RuleBase:RU366024}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|RuleBase:RU366024}; Note=Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+). {ECO:0000256|RuleBase:RU366024};

Chromatin regulator;Coiled coil;DNA recombination;DNA-binding;Endonuclease;Hydrolase;Metal-binding;Multifunctional enzyme;Nuclease;Nucleus;Reference proteome;Transferase;Ubl conjugation pathway;Zinc;Zinc-finger

adaptive immune response [GO:0002250]; chromatin organization [GO:0006325]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]

DNA recombinase complex [GO:0097519]; endodeoxyribonuclease complex [GO:1905347]; nucleus [GO:0005634]

double-stranded DNA endonuclease activity [GO:1990238]; histone binding [GO:0042393]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00820, ECO:0000256|RuleBase:RU366024}.

DOMAIN: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. {ECO:0000256|PROSITE-ProRule:PRU00820}.

IPR024627;IPR035714;IPR019485;IPR023336;IPR036236;IPR018957;IPR001841;IPR013083;IPR017907;

6.10.140.510;3.30.160.60;3.30.40.10;

A0A2I2ZH84

MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC

Gorilla gorilla gorilla (Western lowland gorilla)

3.4.24.24

CATALYTIC ACTIVITY: Reaction=Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.; EC=3.4.24.24; Evidence={ECO:0000256|ARBA:ARBA00000178};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR621190-2}; Note=Can bind about 5 Ca(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR621190-2}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR621190-2}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR621190-2};

Calcium;Collagen degradation;Disulfide bond;Extracellular matrix;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen

blood vessel maturation [GO:0001955]; bone trabecula formation [GO:0060346]; cellular response to amino acid stimulus [GO:0071230]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; embryo implantation [GO:0007566]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; face morphogenesis [GO:0060325]; intramembranous ossification [GO:0001957]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; tissue remodeling [GO:0048771]

extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]

metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.

IPR000562;IPR036943;IPR000585;IPR036375;IPR018487;IPR018486;IPR013806;IPR033739;IPR024079;IPR001818;IPR021190;IPR021158;IPR006026;

3.40.390.10;2.10.10.10;2.110.10.10;

A0A2I2ZHI3

LPSWLGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQGEGPLCLPPPTPFSLHTQRGLQCSAFLASDVLKSKYLKRFLLESASDQGGRQCSEGPGPCVNLWGPVSVSWQYGSVLAAL

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

ATP-binding;Glycogen biosynthesis;Kinase;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase

activation-induced cell death of T cells [GO:0006924]; apoptotic mitochondrial changes [GO:0008637]; behavioral response to pain [GO:0048266]; canonical NF-kappaB signal transduction [GO:0007249]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to cadmium ion [GO:0071276]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to reactive oxygen species [GO:0034614]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of protein localization to mitochondrion [GO:0072655]; execution phase of apoptosis [GO:0097194]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen cell differentiation involved in embryonic placenta development [GO:0060709]; inflammatory response [GO:0006954]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; maintenance of protein location in mitochondrion [GO:0072656]; mammalian oogenesis stage [GO:0022605]; maternal placenta development [GO:0001893]; negative regulation of autophagy [GO:0010507]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of cilium assembly [GO:1902018]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of protein localization to lysosome [GO:0150033]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; non-canonical NF-kappaB signal transduction [GO:0038061]; osteoblast differentiation [GO:0001649]; peripheral nervous system myelin maintenance [GO:0032287]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of organ growth [GO:0046622]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to endoplasmic reticulum [GO:1905552]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein ubiquitination [GO:0016567]; regulation of myelination [GO:0031641]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; regulation of tRNA methylation [GO:0110002]; response to fluid shear stress [GO:0034405]; response to food [GO:0032094]; response to heat [GO:0009408]; response to UV-A [GO:0070141]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; striated muscle cell differentiation [GO:0051146]

cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; vesicle [GO:0031982]

14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; nitric-oxide synthase regulator activity [GO:0030235]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; potassium channel activator activity [GO:0099104]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]

IPR000961;IPR011009;IPR011993;IPR001849;IPR039026;IPR017892;IPR000719;IPR017441;IPR008271;

2.30.29.30;1.10.510.10;

A0A2I2ZHZ0

MLQLMDGGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNAASPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

Apoptosis;ATP-binding;Coiled coil;Kinase;Nucleotide-binding;Reference proteome;Transferase

canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; primitive hemopoiesis [GO:0060215]; protein import into nucleus [GO:0006606]; protein localization to centrosome [GO:0071539]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]

centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR024205;IPR049568;IPR036674;IPR000719;IPR017441;IPR011524;

1.10.287.4270;4.10.170.10;1.10.510.10;

A0A2I2ZIP4

MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNTTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEVEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPPAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKQPKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQTVPQIKPVSQPVGVEQQAALLKPDLVRSLNQDVATTKENISSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDVPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSESEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVVPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIETAKSQLVEIEPATQNPKTSFSSEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

ATP-binding;Coiled coil;Kinase;Nucleotide-binding;Reference proteome;Transferase

cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; non-membrane-bounded organelle assembly [GO:0140694]; osmosensory signaling pathway [GO:0007231]; phosphorylation [GO:0016310]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of calcium ion import [GO:0090279]

adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]

ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; potassium channel inhibitor activity [GO:0019870]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR024678;IPR000719;IPR008271;

1.10.510.10;

A0A2I2ZJ84

MPVTPGTFHVSEEALSHLLLPFQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVSARGHC

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.4.6

ATP-binding;Cell cycle;Nucleotide-binding;Reference proteome

abscission [GO:0009838]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; intracellular cholesterol transport [GO:0032367]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cytokinesis [GO:0032466]; nucleus organization [GO:0006997]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to lysosome [GO:0006622]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]

centrosome [GO:0005813]; cytosol [GO:0005829]; early endosome [GO:0005769]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774]

ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein-containing complex binding [GO:0044877]

SUBCELLULAR LOCATION: Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004633}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR003593;IPR041569;IPR003959;IPR003960;IPR007330;IPR036181;IPR027417;IPR045253;

1.10.8.60;3.40.50.300;1.20.58.80;

A0A2I2ZJL0

MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIFDVTESQIIIIICQLLTGTLGPWFWNFTIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. {ECO:0000256|ARBA:ARBA00037663}.

2.7.8.1; 2.7.8.2; 2.7.8.22

CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54336, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:83717, ChEBI:CHEBI:84417; Evidence={ECO:0000256|ARBA:ARBA00035878}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54337; Evidence={ECO:0000256|ARBA:ARBA00035878}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54340, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:84417, ChEBI:CHEBI:138145; Evidence={ECO:0000256|ARBA:ARBA00036341}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54341; Evidence={ECO:0000256|ARBA:ARBA00036341}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54240, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74669; Evidence={ECO:0000256|ARBA:ARBA00036096}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54241; Evidence={ECO:0000256|ARBA:ARBA00036096}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54248, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:74986; Evidence={ECO:0000256|ARBA:ARBA00036523}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54249; Evidence={ECO:0000256|ARBA:ARBA00036523}; CATALYTIC ACTIVITY: Reaction=1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54236, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:78226; Evidence={ECO:0000256|ARBA:ARBA00036329}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54237; Evidence={ECO:0000256|ARBA:ARBA00036329}; CATALYTIC ACTIVITY: Reaction=1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54232, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:76979, ChEBI:CHEBI:78228; Evidence={ECO:0000256|ARBA:ARBA00036651}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54233; Evidence={ECO:0000256|ARBA:ARBA00036651}; CATALYTIC ACTIVITY: Reaction=1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:36227, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77286, ChEBI:CHEBI:77296; EC=2.7.8.22; Evidence={ECO:0000256|ARBA:ARBA00036576}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36228; Evidence={ECO:0000256|ARBA:ARBA00036576}; CATALYTIC ACTIVITY: Reaction=1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:36179, ChEBI:CHEBI:15378, ChEBI:CHEBI:36702, ChEBI:CHEBI:52595, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence={ECO:0000256|ARBA:ARBA00035779}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36180; Evidence={ECO:0000256|ARBA:ARBA00035779}; CATALYTIC ACTIVITY: Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54352, ChEBI:CHEBI:15378, ChEBI:CHEBI:55430, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77184; Evidence={ECO:0000256|ARBA:ARBA00036748}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54353; Evidence={ECO:0000256|ARBA:ARBA00036748}; CATALYTIC ACTIVITY: Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54348, ChEBI:CHEBI:15378, ChEBI:CHEBI:44811, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:75936; Evidence={ECO:0000256|ARBA:ARBA00036059}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54349; Evidence={ECO:0000256|ARBA:ARBA00036059}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54332, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74963, ChEBI:CHEBI:82949; Evidence={ECO:0000256|ARBA:ARBA00036100}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54333; Evidence={ECO:0000256|ARBA:ARBA00036100}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54244, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:73001, ChEBI:CHEBI:75466; Evidence={ECO:0000256|ARBA:ARBA00036890}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54245; Evidence={ECO:0000256|ARBA:ARBA00036890}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54252, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:73007, ChEBI:CHEBI:75466; Evidence={ECO:0000256|ARBA:ARBA00035972}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54253; Evidence={ECO:0000256|ARBA:ARBA00035972}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:32939, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence={ECO:0000256|ARBA:ARBA00035868}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32940; Evidence={ECO:0000256|ARBA:ARBA00035868}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:32943, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:64612; EC=2.7.8.1; Evidence={ECO:0000256|ARBA:ARBA00036031}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32944; Evidence={ECO:0000256|ARBA:ARBA00036031};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.; PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. {ECO:0000256|ARBA:ARBA00037890}.; PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. {ECO:0000256|ARBA:ARBA00037891}.

Endoplasmic reticulum;Glycoprotein;Lipid biosynthesis;Lipid metabolism;Manganese;Membrane;Nucleus;Phospholipid biosynthesis;Phospholipid metabolism;Reference proteome;Transferase;Transmembrane;Transmembrane helix

phosphatidylethanolamine biosynthetic process [GO:0006646]

endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]

diacylglycerol cholinephosphotransferase activity [GO:0004142]; ethanolaminephosphotransferase activity [GO:0004307]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004232}.

IPR000462;IPR043130;IPR048254;IPR014472;

1.20.120.1760;

A0A2I2ZKH1

GRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVPQSMAHPCGGTPTYPESQIFFPTIHERPVSFSPPPTCPPKVAISQRRKSTSFLEAQTHHFQPLLRTVGQSLLPPGGSPTNWTPEAVVMLGTTASRVTGESCEIQVHPMFEPSQVYSDYRPGLVLPEEAHYFIPQEAVYVAGVHYQARVAEQYEGIPYNSSVLSSPMKQIPEQKPVQGGPTSSSVFEFPSGQAFLVGHLQNLRLDSGLSLGSPLSSISAPISTDATRLKFHPVFVPHSAPAVLTHNNESRSNCVFEFHVHTPSSSSGEGGGILPQRVYRNRQVAVDLNQEELPPQSVGLHGYLQPVTEEKHNYHAPELTVSVVEPIGQNWPIGSPEYSSDSSQITSSDPSDFQSPPPTGGAAAPFGSDVSMPFIHLPQTVLQESPLFFCFPQGTTSQQVLTASFSSGGSALHPQAQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPLSTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVPLSSGDVLYQGFPPRLPPQYPGDSNIAPSSNVASVCIHSTVLSPPMPTEVLATTGYFPTVVQPYVESNLLVPMGGVGGQVQGSPPGVSLAQALTTSSQQAVLESTQGVSQVAPAEPVAVAQPQPTQPTTLASSVDSAHSDVASGMSDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSESVVSSTALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLSIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAGVSSSISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHCPEIDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEIITVTSAVGPVSVVAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADDAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLVKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPKKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHLKEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGCAKFNCASEQVTFKPGGRRTRFLRKMVKKVCPCNQLCRTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPVGTASLQNFNISNLQKSISNPPGSNLRTT

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Transferase

cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic ion homeostasis [GO:0050801]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; non-membrane-bounded organelle assembly [GO:0140694]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]

ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; potassium channel inhibitor activity [GO:0019870]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR024678;IPR000719;IPR008271;

1.10.510.10;

A0A2I2ZMW0

MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWIFSPMESASSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNKSHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRRDSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTYGQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSRENYENYIPADSFIHVEDYNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHACLACDHVKRHQEYKSVGNLEKWFWN

Gorilla gorilla gorilla (Western lowland gorilla)

2.4.1.-

CATALYTIC ACTIVITY: Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:14257, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:137941; EC=2.4.1.152; Evidence={ECO:0000256|ARBA:ARBA00029329}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14258; Evidence={ECO:0000256|ARBA:ARBA00029329}; CATALYTIC ACTIVITY: Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48376, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90376, ChEBI:CHEBI:90379; Evidence={ECO:0000256|ARBA:ARBA00036757}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48377; Evidence={ECO:0000256|ARBA:ARBA00036757}; CATALYTIC ACTIVITY: Reaction=alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48380, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90380, ChEBI:CHEBI:90381; Evidence={ECO:0000256|ARBA:ARBA00036053}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48381; Evidence={ECO:0000256|ARBA:ARBA00036053}; CATALYTIC ACTIVITY: Reaction=alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48388, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90383, ChEBI:CHEBI:90384; Evidence={ECO:0000256|ARBA:ARBA00036295}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48389; Evidence={ECO:0000256|ARBA:ARBA00036295}; CATALYTIC ACTIVITY: Reaction=an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:56076, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:136545, ChEBI:CHEBI:139509; Evidence={ECO:0000256|ARBA:ARBA00036481}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56077; Evidence={ECO:0000256|ARBA:ARBA00036481}; CATALYTIC ACTIVITY: Reaction=an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:77191, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133510, ChEBI:CHEBI:195560; Evidence={ECO:0000256|ARBA:ARBA00043838}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77192; Evidence={ECO:0000256|ARBA:ARBA00043838}; CATALYTIC ACTIVITY: Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:68044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:145343, ChEBI:CHEBI:176900; Evidence={ECO:0000256|ARBA:ARBA00036234}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68045; Evidence={ECO:0000256|ARBA:ARBA00036234}; CATALYTIC ACTIVITY: Reaction=beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+); Xref=Rhea:RHEA:77187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:60239, ChEBI:CHEBI:61352; Evidence={ECO:0000256|ARBA:ARBA00043828}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77188; Evidence={ECO:0000256|ARBA:ARBA00043828};

PATHWAY: Glycolipid biosynthesis. {ECO:0000256|ARBA:ARBA00004934}.; PATHWAY: Protein modification; protein glycosylation. {ECO:0000256|ARBA:ARBA00004922}.

Glycoprotein;Glycosyltransferase;Golgi apparatus;Lipid metabolism;Membrane;Reference proteome;Signal-anchor;Transferase;Transmembrane;Transmembrane helix

fucosylation [GO:0036065]; glycosphingolipid biosynthetic process [GO:0006688]; Lewis x epitope biosynthetic process [GO:0106402]; N-glycan fucosylation [GO:0036071]; neuron differentiation [GO:0030182]; neuronal stem cell division [GO:0036445]; oligosaccharide biosynthetic process [GO:0009312]; polysaccharide biosynthetic process [GO:0000271]; positive regulation of neuron projection development [GO:0010976]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; regulation of leukocyte tethering or rolling [GO:1903236]

Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]; protein homodimerization activity [GO:0042803]

SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004394}. Golgi apparatus, Golgi stack membrane {ECO:0000256|RuleBase:RU003832}; Single-pass type II membrane protein {ECO:0000256|RuleBase:RU003832}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00037848}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00037848}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.

IPR031481;IPR001503;IPR038577;

3.40.50.11660;

A0A2I2ZNE4

MSPAPRPSRCLLLPLLTLGTALACLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV

Gorilla gorilla gorilla (Western lowland gorilla)

3.4.24.80

CATALYTIC ACTIVITY: Reaction=Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.; EC=3.4.24.80; Evidence={ECO:0000256|ARBA:ARBA00001718};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR621190-2}; Note=Can bind about 5 Ca(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR621190-2}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR621190-2}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR621190-2};

Calcium;Cleavage on pair of basic residues;Cytoplasm;Hydrolase;Membrane;Metal-binding;Metalloprotease;Phosphoprotein;Protease;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen

branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; head development [GO:0060322]; lung development [GO:0030324]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell growth [GO:0030307]; positive regulation of macrophage migration [GO:1905523]; positive regulation of myotube differentiation [GO:0010831]; regulation of protein localization to plasma membrane [GO:1903076]; skeletal system development [GO:0001501]; zymogen activation [GO:0031638]

cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; intermediate filament cytoskeleton [GO:0045111]; macropinosome [GO:0044354]; melanosome [GO:0042470]; nucleus [GO:0005634]; plasma membrane [GO:0005886]

metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Melanosome {ECO:0000256|ARBA:ARBA00004223}.

IPR000585;IPR036375;IPR018487;IPR018486;IPR033739;IPR024079;IPR001818;IPR021190;IPR021805;IPR021158;IPR006026;IPR002477;IPR036365;IPR036366;

3.40.390.10;2.110.10.10;1.10.101.10;

A0A2I2ZPX0

MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASAGPLGCCR

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. {ECO:0000256|RuleBase:RU368052}.

2.7.11.24

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000494}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000088};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|RuleBase:RU368052};

ATP-binding;Biological rhythms;Kinase;Magnesium;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase

cellular response to amino acid starvation [GO:0034198]; cellular response to cadmium ion [GO:0071276]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to reactive oxygen species [GO:0034614]; JNK cascade [GO:0007254]; negative regulation of apoptotic process [GO:0043066]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein metabolic process [GO:0051247]; regulation of protein localization [GO:0032880]; response to mechanical stimulus [GO:0009612]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; stress-activated MAPK cascade [GO:0051403]

cytoplasm [GO:0005737]; nucleus [GO:0005634]

ATP binding [GO:0005524]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; JUN kinase activity [GO:0004705]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase binding [GO:0120283]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368052}.

IPR011009;IPR003527;IPR008351;IPR000719;IPR008271;

1.10.510.10;

A0A2I2ZRU3

MAAAPSYPAGLPGSPGPGSTPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSAGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGARPPQDHDMQGLAERISVL

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569, ECO:0000256|PIRNR:PIRNR000552};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|PIRNR:PIRNR000552};

ATP-binding;Cytoplasm;Kinase;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc

intracellular signal transduction [GO:0035556]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of T cell receptor signaling pathway [GO:0050862]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein modification process [GO:0036211]; regulation of T cell apoptotic process [GO:0070232]; T cell receptor signaling pathway [GO:0050852]

cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]

ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR000552}. Membrane {ECO:0000256|ARBA:ARBA00004370}.

IPR046349;IPR020454;IPR011009;IPR002219;IPR011993;IPR001849;IPR000719;IPR017441;IPR015727;IPR008271;

3.30.60.20;2.30.29.30;1.10.510.10;

A0A2I2ZTJ4

MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP

Gorilla gorilla gorilla (Western lowland gorilla)

FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. {ECO:0000256|PIRNR:PIRNR039050}.

4.6.1.1

CATALYTIC ACTIVITY: Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000256|ARBA:ARBA00001593, ECO:0000256|PIRNR:PIRNR039050};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|PIRNR:PIRNR039050}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

ATP-binding;cAMP biosynthesis;Lyase;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Reference proteome;Transmembrane;Transmembrane helix

adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; cellular response to glucagon stimulus [GO:0071377]; cellular response to morphine [GO:0071315]; glucose mediated signaling pathway [GO:0010255]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; neuroinflammatory response [GO:0150076]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synaptic plasticity [GO:0031915]; regulation of cellular response to stress [GO:0080135]; regulation of cytosolic calcium ion concentration [GO:0051480]

apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body membrane [GO:0032809]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]

adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]; metal ion binding [GO:0046872]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR001054;IPR018297;IPR032628;IPR030672;IPR009398;IPR029787;

3.30.70.1230;

A0A2I2ZUK5

MGLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRVRGGASVTSTLQLQVQPSSQLSTPLASTPSKTHLCSCPGSLLTPTHHLLTPTLARPPCLCLISAPTHTAPSIFDPDVPLT

Gorilla gorilla gorilla (Western lowland gorilla)

3.6.4.12

CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00001665};

COFACTOR: Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000256|ARBA:ARBA00001966};

ATP-binding;DNA-binding;Helicase;Hydrolase;Nucleotide-binding;Nucleus;Reference proteome

bone mineralization [GO:0030282]; central nervous system myelin formation [GO:0032289]; chromosome segregation [GO:0007059]; determination of adult lifespan [GO:0008340]; embryonic cleavage [GO:0040016]; erythrocyte maturation [GO:0043249]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; hair follicle maturation [GO:0048820]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell proliferation [GO:0071425]; in utero embryonic development [GO:0001701]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; multicellular organism growth [GO:0035264]; positive regulation of mitotic recombination [GO:0045951]; post-embryonic development [GO:0009791]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979]; spinal cord development [GO:0021510]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]

CAK-ERCC2 complex [GO:0070516]; cytosol [GO:0005829]; MMXD complex [GO:0071817]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]

5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; protein-macromolecule adaptor activity [GO:0030674]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR006555;IPR045028;IPR002464;IPR010643;IPR014013;IPR006554;IPR027417;IPR010614;IPR013020;IPR001945;

3.40.50.300;

A0A2I2ZV31

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.22

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000256|ARBA:ARBA00000584}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000256|ARBA:ARBA00000875};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

ATP-binding;DNA damage;DNA repair;Kinase;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase

centriole replication [GO:0007099]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated DNA replication initiation [GO:0032298]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of heterochromatin formation [GO:0031453]; post-translational protein modification [GO:0043687]; potassium ion transport [GO:0006813]; Ras protein signal transduction [GO:0007265]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of gene expression [GO:0010468]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]

Cajal body [GO:0015030]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; cyclin A1-CDK2 complex [GO:0097123]; cyclin A2-CDK2 complex [GO:0097124]; cyclin E1-CDK2 complex [GO:0097134]; cyclin E2-CDK2 complex [GO:0097135]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; endosome [GO:0005768]; male germ cell nucleus [GO:0001673]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]; X chromosome [GO:0000805]; Y chromosome [GO:0000806]

ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, Cajal body {ECO:0000256|ARBA:ARBA00004408}.

IPR011009;IPR000719;IPR017441;IPR008271;

1.10.510.10;

A0A2I2ZVD2

SHHRWPFHVPRLLFIPLPTSNWNNLSLFPALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

Gorilla gorilla gorilla (Western lowland gorilla)

2.7.11.30

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023945}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023948};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

Apoptosis;ATP-binding;Cell junction;Differentiation;Growth regulation;Isopeptide bond;Kinase;Magnesium;Manganese;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Serine/threonine-protein kinase;Signal;Tight junction;Transferase;Transmembrane;Transmembrane helix;Ubl conjugation

activin receptor signaling pathway [GO:0032924]; angiogenesis involved in coronary vascular morphogenesis [GO:0060978]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; cellular response to growth factor stimulus [GO:0071363]; collagen fibril organization [GO:0030199]; coronary artery morphogenesis [GO:0060982]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epicardium morphogenesis [GO:1905223]; epithelial to mesenchymal transition [GO:0001837]; filopodium assembly [GO:0046847]; germ cell migration [GO:0008354]; heart development [GO:0007507]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; male gonad development [GO:0008584]; myofibroblast differentiation [GO:0036446]; negative regulation of cell migration [GO:0030336]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; nervous system development [GO:0007399]; neuron fate commitment [GO:0048663]; parathyroid gland development [GO:0060017]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of gene expression [GO:0010628]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of vasculature development [GO:1904018]; post-embryonic development [GO:0009791]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of protein ubiquitination [GO:0031396]; response to cholesterol [GO:0070723]; roof of mouth development [GO:0060021]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]

activin receptor complex [GO:0048179]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; endosome [GO:0005768]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transforming growth factor beta ligand-receptor complex [GO:0070021]

activin binding [GO:0048185]; activin receptor activity, type I [GO:0016361]; ATP binding [GO:0005524]; I-SMAD binding [GO:0070411]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity, type I [GO:0005025]; type II transforming growth factor beta receptor binding [GO:0005114]; ubiquitin protein ligase binding [GO:0031625]

SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Cell surface {ECO:0000256|ARBA:ARBA00004241}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR000472;IPR003605;IPR011009;IPR000719;IPR017441;IPR008271;IPR045860;IPR000333;

2.10.60.10;1.10.510.10;

A0A2I3RAU3

ALHSVPHSPPTTCLAARTPCRRPAEMLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF

Pan troglodytes (Chimpanzee)

FUNCTION: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. {ECO:0000256|ARBA:ARBA00037436}.

5.6.1.7

CATALYTIC ACTIVITY: Reaction=ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.; EC=5.6.1.7; Evidence={ECO:0000256|ARBA:ARBA00034033};

ATP-binding;Chaperone;Nucleotide-binding;Reference proteome

apoptotic mitochondrial changes [GO:0008637]; B cell proliferation [GO:0042100]; biological process involved in interaction with symbiont [GO:0051702]; chaperone cofactor-dependent protein refolding [GO:0051085]; isotype switching to IgG isotypes [GO:0048291]; mitochondrial unfolded protein response [GO:0034514]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage activation [GO:0043032]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; positive regulation of type II interferon production [GO:0032729]; protein folding [GO:0006457]; protein import into mitochondrial intermembrane space [GO:0045041]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; T cell activation [GO:0042110]

cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; GroEL-GroES complex [GO:1990220]; lipopolysaccharide receptor complex [GO:0046696]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]

apolipoprotein A-I binding [GO:0034186]; ATP binding [GO:0005524]; ATP-dependent protein folding chaperone [GO:0140662]; double-stranded RNA binding [GO:0003725]; high-density lipoprotein particle binding [GO:0008035]; lipopolysaccharide binding [GO:0001530]; p53 binding [GO:0002039]; protein-folding chaperone binding [GO:0051087]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]

IPR018370;IPR001844;IPR002423;IPR027409;IPR027413;IPR027410;

3.50.7.10;1.10.560.10;3.30.260.10;

A0A2I3RB45

IHKEHSCTLVRKYHVWLLPQVPKSKAQEAVKLAIEAGFRHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNMQVRSGAVAIDGLNRNVRYLTLDIFAGPPNYPFSDEY

Pan troglodytes (Chimpanzee)

CATALYTIC ACTIVITY: Reaction=(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH; Xref=Rhea:RHEA:16729, ChEBI:CHEBI:10702, ChEBI:CHEBI:15378, ChEBI:CHEBI:18135, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.20; Evidence={ECO:0000256|ARBA:ARBA00036133}; CATALYTIC ACTIVITY: Reaction=(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone; Xref=Rhea:RHEA:42108, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28453, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00023933}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42109; Evidence={ECO:0000256|ARBA:ARBA00023933}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42110; Evidence={ECO:0000256|ARBA:ARBA00023933}; CATALYTIC ACTIVITY: Reaction=(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone; Xref=Rhea:RHEA:42112, ChEBI:CHEBI:15378, ChEBI:CHEBI:17026, ChEBI:CHEBI:28453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000256|ARBA:ARBA00023980}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42113; Evidence={ECO:0000256|ARBA:ARBA00023980}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42114; Evidence={ECO:0000256|ARBA:ARBA00023980}; CATALYTIC ACTIVITY: Reaction=(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH; Xref=Rhea:RHEA:16317, ChEBI:CHEBI:15378, ChEBI:CHEBI:17404, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:156384; EC=1.1.1.112; Evidence={ECO:0000256|ARBA:ARBA00036985}; CATALYTIC ACTIVITY: Reaction=(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH; Xref=Rhea:RHEA:16321, ChEBI:CHEBI:15378, ChEBI:CHEBI:17404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:156384; EC=1.1.1.112; Evidence={ECO:0000256|ARBA:ARBA00036983}; CATALYTIC ACTIVITY: Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence={ECO:0000256|ARBA:ARBA00023927}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence={ECO:0000256|ARBA:ARBA00023927}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24614; Evidence={ECO:0000256|ARBA:ARBA00023927}; CATALYTIC ACTIVITY: Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence={ECO:0000256|ARBA:ARBA00023984}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24617; Evidence={ECO:0000256|ARBA:ARBA00023984}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24618; Evidence={ECO:0000256|ARBA:ARBA00023984}; CATALYTIC ACTIVITY: Reaction=a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH; Xref=Rhea:RHEA:34779, ChEBI:CHEBI:15378, ChEBI:CHEBI:36835, ChEBI:CHEBI:47788, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.357; Evidence={ECO:0000256|ARBA:ARBA00023972}; CATALYTIC ACTIVITY: Reaction=a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:34783, ChEBI:CHEBI:15378, ChEBI:CHEBI:36835, ChEBI:CHEBI:47788, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.357; Evidence={ECO:0000256|ARBA:ARBA00023921};

PATHWAY: Steroid metabolism. {ECO:0000256|ARBA:ARBA00004854}.

NADP;Reference proteome

cellular response to jasmonic acid stimulus [GO:0071395]; cellular response to prostaglandin D stimulus [GO:0071799]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; epithelial cell differentiation [GO:0030855]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; progesterone metabolic process [GO:0042448]; prostaglandin metabolic process [GO:0006693]

cytosol [GO:0005829]

alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; androsterone dehydrogenase activity [GO:0047023]; bile acid binding [GO:0032052]; estradiol 17-beta-dehydrogenase [NAD(P)] activity [GO:0004303]; ketosteroid monooxygenase activity [GO:0047086]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; phenanthrene 9,10-monooxygenase activity [GO:0018636]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]

IPR020471;IPR044482;IPR018170;IPR023210;IPR036812;

3.20.20.100;

A0A2I3RC03

MLSGKKAAAAAAAAAAAAAGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM

Pan troglodytes (Chimpanzee)

FUNCTION: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. {ECO:0000256|PIRNR:PIRNR038051}.

1.14.99.66

CATALYTIC ACTIVITY: Reaction=2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]; Xref=Rhea:RHEA:60244, Rhea:RHEA-COMP:15540, Rhea:RHEA-COMP:15547, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16842, ChEBI:CHEBI:17499, ChEBI:CHEBI:29969, ChEBI:CHEBI:61976; EC=1.14.99.66; Evidence={ECO:0000256|PIRNR:PIRNR038051};

COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|ARBA:ARBA00001974, ECO:0000256|PIRNR:PIRNR038051, ECO:0000256|PIRSR:PIRSR038051-1};

Chromatin regulator;Coiled coil;FAD;Flavoprotein;Nucleus;Oxidoreductase;Reference proteome;Repressor;Transcription;Transcription regulation

cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA methylation-dependent heterochromatin formation [GO:0090308]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of protein localization [GO:0032880]

chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; DNA repair complex [GO:1990391]; nucleoplasm [GO:0005654]

chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; flavin adenine dinucleotide binding [GO:0050660]; histone H3K9 demethylase activity [GO:0032454]; identical protein binding [GO:0042802]; MRF binding [GO:0043426]; nuclear androgen receptor binding [GO:0050681]; nuclear receptor coactivator activity [GO:0030374]; oxidoreductase activity [GO:0016491]; p53 binding [GO:0002039]; telomeric repeat-containing RNA binding [GO:0061752]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038051}.

DOMAIN: The SWIRM domain may act as an anchor site for a histone tail. {ECO:0000256|PIRNR:PIRNR038051}.

IPR002937;IPR036188;IPR017366;IPR009057;IPR007526;IPR036388;

3.90.660.10;1.10.287.80;3.50.50.60;1.10.10.10;

A0A2I3RDV0

MGREELFLTFSFSSGFQESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQITFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWRKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

Pan troglodytes (Chimpanzee)

3.6.1.5

CATALYTIC ACTIVITY: Reaction=2 H2O + ITP = 2 H(+) + IMP + 2 phosphate; Xref=Rhea:RHEA:77735, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; Evidence={ECO:0000256|ARBA:ARBA00043682}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77736; Evidence={ECO:0000256|ARBA:ARBA00043682}; CATALYTIC ACTIVITY: Reaction=2 H2O + UTP = 2 H(+) + 2 phosphate + UMP; Xref=Rhea:RHEA:64896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:57865; Evidence={ECO:0000256|ARBA:ARBA00043678}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64897; Evidence={ECO:0000256|ARBA:ARBA00043678}; CATALYTIC ACTIVITY: Reaction=ADP + H2O = AMP + H(+) + phosphate; Xref=Rhea:RHEA:61436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036139}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61437; Evidence={ECO:0000256|ARBA:ARBA00036139}; CATALYTIC ACTIVITY: Reaction=ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:20988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00043702}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20989; Evidence={ECO:0000256|ARBA:ARBA00043702}; CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00034440}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000256|ARBA:ARBA00034440}; CATALYTIC ACTIVITY: Reaction=CDP + H2O = CMP + H(+) + phosphate; Xref=Rhea:RHEA:64880, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00043676}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64881; Evidence={ECO:0000256|ARBA:ARBA00043676}; CATALYTIC ACTIVITY: Reaction=CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:64908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00043680}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64909; Evidence={ECO:0000256|ARBA:ARBA00043680}; CATALYTIC ACTIVITY: Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence={ECO:0000256|ARBA:ARBA00043776}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; Evidence={ECO:0000256|ARBA:ARBA00043776}; CATALYTIC ACTIVITY: Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; Evidence={ECO:0000256|ARBA:ARBA00043654}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence={ECO:0000256|ARBA:ARBA00043654}; CATALYTIC ACTIVITY: Reaction=GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:64904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115; Evidence={ECO:0000256|ARBA:ARBA00043766}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64905; Evidence={ECO:0000256|ARBA:ARBA00043766}; CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000256|ARBA:ARBA00001702}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00001702}; CATALYTIC ACTIVITY: Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; Evidence={ECO:0000256|ARBA:ARBA00043688}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; Evidence={ECO:0000256|ARBA:ARBA00043688}; CATALYTIC ACTIVITY: Reaction=H2O + ITP = H(+) + IDP + phosphate; Xref=Rhea:RHEA:28330, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; Evidence={ECO:0000256|ARBA:ARBA00043752}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28331; Evidence={ECO:0000256|ARBA:ARBA00043752}; CATALYTIC ACTIVITY: Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; Evidence={ECO:0000256|ARBA:ARBA00043716}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; Evidence={ECO:0000256|ARBA:ARBA00043716}; CATALYTIC ACTIVITY: Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence={ECO:0000256|ARBA:ARBA00043661}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64901; Evidence={ECO:0000256|ARBA:ARBA00043661}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; Evidence={ECO:0000256|ARBA:ARBA00043714}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; Evidence={ECO:0000256|ARBA:ARBA00043714}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; Evidence={ECO:0000256|ARBA:ARBA00043753}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36796; Evidence={ECO:0000256|ARBA:ARBA00043753}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; Evidence={ECO:0000256|ARBA:ARBA00043686}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence={ECO:0000256|ARBA:ARBA00043686};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00001913}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

ATP-binding;Calcium;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Nucleotide-binding;Reference proteome;Transmembrane;Transmembrane helix

nucleoside diphosphate catabolic process [GO:0009134]; platelet aggregation [GO:0070527]

caveola [GO:0005901]; plasma membrane [GO:0005886]

ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR000407;

3.30.420.40;3.30.420.150;