Datasets:

lhallee

/

exp_new_unprocessed

like 0

A0A517FNC5

MAPVVILFFLFPTLLVLVVAVLGLRGGDDSWKKRGLKVPPGSMGWPLLGETIAFRRLHPCTSLGEYMEEHVNKYGKIYRSNLFGAPTIVSADAELNRFVLMNDERLFEPCFPKSVADILGHTSMLVLTGEMHRYMKSLSVNFMGIARLRNNFLGDSELYITQNFNRWKENIPFPAKEEACKVTFNLMVKNILSLNPGEPESEHLRKLYMSFMKGVVAIPLNLPGTAYKKAIQSRATILKMIEKLMEERIRNKKAGTDKIGEADLLGFILEQSNLDAEQFGDLLLGLLFGGHETSATAITLVIYFLYDCPKAVDHLREEHLGIVRAKKARGEPPALTWDDYKQMEFSQCVVSETLRLGNIIKFVHRKAKTDVQFKGYDIPKGWSVIPVFAAAHLDPSVYENPQKFDPWRWQTISTGTARIDNYMPFGQGLRNCAGLELAKMEIVVFLHHLTLNFDWEMAEPDHPLAYAFPDFPKGLPIKVRRLALK

Paris polyphylla (Daiswa polyphylla)

FUNCTION: Involved in the biosynthesis of spiroketal steroid and saponin natural products from cholesterol such as diosgenin and analogs (e.g. furostanol and spirostanol), plant defense compounds used as main precursors for the industrial production of steroid hormones (PubMed:31324795). During the 5,6-spiroketalization of cholesterol, catalyzes the hydroxylation of cholesterol to form 16S,22S-dihydroxycholesterol and, possibly, the subsequent conversion of 16S,22S-dihydroxycholesterol into 16-oxo-22-hydroxy-cholesterol and 16-hydroxy-22-oxo-cholesterol (PubMed:31324795). 16-hydroxy-22-oxo-cholesterol submit a spontaneous reaction leading to the production of furostanol-type steroid diastereomers, precursors of diosgenin (PubMed:31324795). {ECO:0000269|PubMed:31324795}.

1.14.14.-

CATALYTIC ACTIVITY: Reaction=cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:72191, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:191938; Evidence={ECO:0000269|PubMed:31324795}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72192; Evidence={ECO:0000269|PubMed:31324795};

PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000269|PubMed:31324795}.

Cholesterol metabolism;Heme;Iron;Lipid biosynthesis;Lipid metabolism;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Steroid biosynthesis;Steroid metabolism;Sterol metabolism;Transmembrane;Transmembrane helix

cholesterol metabolic process [GO:0008203]; saponin biosynthetic process [GO:0016135]; steroid biosynthetic process [GO:0006694]

membrane [GO:0016020]

heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

IPR001128;IPR017972;IPR002401;IPR036396;

1.10.630.10;

A0A517FNC6

MSDSDITFYCLSSILSVLLIFIFILIKRKQAKPKLNLPPGKMGWPFLGETIGYLKPYSATTLGEFMDQHIARYGKIYKSKLFGEPAIVSADAGLNRFILQNEGKLFECSYPRSIGGILGKWSMLVLVGDMHRDMRLISLNFLSHARLRTHLLKEVEKHTRLVISSWKENSTFAAQDEAKKFTFNLMAEHIMSLQPGKIETEKLKKEYVTFMKGVVSAPLNFPGTAYWKALKSRGTILKFIEGKMEERIKRMKEGNENLEEDDLLNWVLKHSNLSTEQILDLILSLLFAGHETSSVSIALAIYFLPGCPQAILQLREEHKEIARAKKQAGETELTWEDYKKMEFTHCVVNETLRLGNVVRFLHRKALKDVRYKGYDIPCGWKVLPVIAAVHLDPLLFDQPQHFNPWRWQNNGNCPNFSGASSNSNNIFLPFGGGPRLCAGSELAKLEMAVFIHHLILNYHWELTDNNDQAFAYPFVDFPKGLQIRVQSHSLI

Trigonella foenum-graecum (Fenugreek)

FUNCTION: Canonical brassinosteroid (BR)-biosynthetic enzyme capable of converting cholesterol to 22S-hydroxycholesterol via sterol-C22 hydroxylation. {ECO:0000269|PubMed:31324795}.

1.14.14.-

CATALYTIC ACTIVITY: Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:69839, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:31324795}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:69840; Evidence={ECO:0000269|PubMed:31324795};

PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000269|PubMed:31324795}.

Brassinosteroid biosynthesis;Cholesterol metabolism;Heme;Iron;Lipid biosynthesis;Lipid metabolism;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Steroid biosynthesis;Steroid metabolism;Sterol metabolism;Transmembrane;Transmembrane helix

brassinosteroid biosynthetic process [GO:0016132]; cholesterol metabolic process [GO:0008203]; steroid biosynthetic process [GO:0006694]

membrane [GO:0016020]

heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

IPR001128;IPR017972;IPR002401;IPR036396;

1.10.630.10;

A0A5B8NIM2

MDAAVDLLDPSKALNLKHIRQQLIRMEDTITFQLIERVQFPLNRTVYEPGAVKIPNSNLSFLDWTLREREKTDSLIRRYQSPDEHPFFPDALLKPILQPLIYPKILHRNNINLNDKIKKYFTDQVLPSICHDFGREDRGEQAENYGSTVTADIQCLQTLSRRIHFGKWVAESKYIDDPQGFAKLIKAGDRQAIGKAITKPAVELQVLERIRLKSRTYSTDPCESDDPEPKINVDAVVAMYRDCVIPLTKEVEIDYLMQRLSD

Erysiphe quercicola (Hevea powdery mildew)

FUNCTION: Catalyzes the Claisen rearrangement of chorismate to prephenate (PubMed:33010586). May function both as an effector during plant infection and in the fungal tyrosine and phenylalanine biosynthesis pathways (PubMed:33010586). During infection it channels chorismate into the phenylpropanoid pathway, thereby decreasing the synthesis of the plant immune signal salicylic acid (Probable). Within fungal cells, it acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (Probable). {ECO:0000269|PubMed:33010586, ECO:0000305|PubMed:33010586}.

5.4.99.5

CATALYTIC ACTIVITY: Reaction=chorismate = prephenate; Xref=Rhea:RHEA:13897, ChEBI:CHEBI:29748, ChEBI:CHEBI:29934; EC=5.4.99.5; Evidence={ECO:0000269|PubMed:33010586}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13898; Evidence={ECO:0000269|PubMed:33010586};

PATHWAY: Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1. {ECO:0000305|PubMed:33010586}.

Amino-acid biosynthesis;Aromatic amino acid biosynthesis;Cytoplasm;Host cytoplasm;Isomerase;Phenylalanine biosynthesis;Secreted;Tyrosine biosynthesis;Virulence

chorismate metabolic process [GO:0046417]; effector-mediated suppression of host salicylic acid-mediated innate immune signaling [GO:0140502]; L-phenylalanine biosynthetic process [GO:0009094]; tyrosine biosynthetic process [GO:0006571]

cytoplasm [GO:0005737]; extracellular region [GO:0005576]; host cell cytoplasm [GO:0030430]

chorismate mutase activity [GO:0004106]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:33010586}. Secreted {ECO:0000305|PubMed:33010586}. Host cytoplasm {ECO:0000305|PubMed:33010586}. Note=Appears to be secreted despite an apparent lack of a secretory signal. {ECO:0000305|PubMed:33010586}.

IPR036263;IPR008238;IPR037039;

1.10.590.10;

A0A5F5PK95

MFLRTSVAALTPLFHALRSAPVAAMSTGTFVVSQPLNYRGGARVEPVDSSGIEKAFEPATGRVIATFACSGEKEVNLAVQDAKAAFKIWSQKSGMERCRILLEAARIIRERRDEIAKVETINNGKSIFEARFDIDISWQSLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSVLLLAEIYTEAGMPPGLFNVVQGGAATGQFLCQHHDVAKVSFTGSVPTGTKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMENAVKGALMANFLTQGEVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKQQGAKVLCGGDLYVPEDPKLKDGYYMRPCILTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTSFGLAAGVFTRDIQRAHRVVAELQAGMCFINNYNVSPVELPFGGYKKSGSCRMKVG

Equus caballus (Horse)

FUNCTION: Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. {ECO:0000256|ARBA:ARBA00043882}.

1.2.1.19; 1.2.1.3; 1.2.1.46; 1.2.1.47

CATALYTIC ACTIVITY: Reaction=(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH; Xref=Rhea:RHEA:31215, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:50157, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62622; Evidence={ECO:0000256|ARBA:ARBA00043724}; CATALYTIC ACTIVITY: Reaction=3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) = 3,4-dihydroxyphenylacetate + 2 H(+) + NADH; Xref=Rhea:RHEA:69080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17612, ChEBI:CHEBI:27978, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00043811}; CATALYTIC ACTIVITY: Reaction=4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:17985, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16244, ChEBI:CHEBI:18020, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.47; Evidence={ECO:0000256|ARBA:ARBA00036400}; CATALYTIC ACTIVITY: Reaction=4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=1.2.1.19; Evidence={ECO:0000256|ARBA:ARBA00043799}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate; Xref=Rhea:RHEA:69092, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:31011, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84069; Evidence={ECO:0000256|ARBA:ARBA00043741}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate; Xref=Rhea:RHEA:67256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17153, ChEBI:CHEBI:17272, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00043823}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2-carboxyethyl)spermidine + NADH; Xref=Rhea:RHEA:69168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:180903, ChEBI:CHEBI:180913; Evidence={ECO:0000256|ARBA:ARBA00043708}; CATALYTIC ACTIVITY: Reaction=H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH; Xref=Rhea:RHEA:67276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:88528; Evidence={ECO:0000256|ARBA:ARBA00043662}; CATALYTIC ACTIVITY: Reaction=H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH; Xref=Rhea:RHEA:31059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27398, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57969; Evidence={ECO:0000256|ARBA:ARBA00043820}; CATALYTIC ACTIVITY: Reaction=acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH; Xref=Rhea:RHEA:25294, ChEBI:CHEBI:15343, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00043790}; CATALYTIC ACTIVITY: Reaction=acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH; Xref=Rhea:RHEA:69084, ChEBI:CHEBI:15368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37080, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00043666}; CATALYTIC ACTIVITY: Reaction=butanal + H2O + NAD(+) = butanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:69088, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15743, ChEBI:CHEBI:17968, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00043754}; CATALYTIC ACTIVITY: Reaction=formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH; Xref=Rhea:RHEA:16425, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:16842, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.46; Evidence={ECO:0000256|ARBA:ARBA00043759};

PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis. {ECO:0000256|ARBA:ARBA00005022}.

NAD;Oxidoreductase;Proteomics identification;Reference proteome;Signal

4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; betaine-aldehyde dehydrogenase activity [GO:0008802]

IPR016161;IPR016163;IPR016160;IPR029510;IPR016162;IPR015590;

A0A5F5PND8

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKCVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW

Equus caballus (Horse)

3.6.5.5

CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; Evidence={ECO:0000256|ARBA:ARBA00001837};

Biological rhythms;Coated pit;Cytoplasmic vesicle;Golgi apparatus;GTP-binding;Lipid-binding;Membrane;Mitochondrion;Mitochondrion outer membrane;Nucleotide-binding;Peroxisome;Reference proteome;Synapse

calcium ion transport [GO:0006816]; endocytosis [GO:0006897]; heart contraction [GO:0060047]; intracellular distribution of mitochondria [GO:0048312]; membrane fusion [GO:0061025]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitocytosis [GO:0160040]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein complex oligomerization [GO:0051259]; protein localization to mitochondrion [GO:0070585]; regulation of ATP metabolic process [GO:1903578]; regulation of gene expression [GO:0010468]; regulation of mitophagy [GO:1901524]; regulation of peroxisome organization [GO:1900063]; release of cytochrome c from mitochondria [GO:0001836]; rhythmic process [GO:0048511]

brush border [GO:0005903]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrion-derived vesicle [GO:0099073]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; synaptic vesicle membrane [GO:0030672]

GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; ubiquitin protein ligase binding [GO:0031625]

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004432}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004450}. Peroxisome {ECO:0000256|ARBA:ARBA00004275}.

IPR022812;IPR001401;IPR019762;IPR045063;IPR000375;IPR030381;IPR003130;IPR020850;IPR027417;

1.20.120.1240;3.40.50.300;

A0A5F5PP73

MDSTTATAELGWIVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACAHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKTIRNPNSLKAVAPLSSGINLPLLDRTIPDYTSFNTVAEWLEAIKMGQYKESFANAGFTSFDVVSQMVMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEAVLPDPAQQPRAGRTGGRAGDGQAATPTTTPGKPVPTATGQTEEFFSLWRIFQKLQ

Equus caballus (Horse)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Developmental protein;Disulfide bond;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

angiogenesis [GO:0001525]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; B cell activation [GO:0042113]; camera-type eye morphogenesis [GO:0048593]; central nervous system projection neuron axonogenesis [GO:0021952]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; dendritic spine morphogenesis [GO:0060997]; ephrin receptor signaling pathway [GO:0048013]; inner ear morphogenesis [GO:0042472]; learning [GO:0007612]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell adhesion [GO:0007162]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of Ras protein signal transduction [GO:0046580]; neuron projection retraction [GO:0106028]; optic nerve morphogenesis [GO:0021631]; phosphorylation [GO:0016310]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell migration [GO:0030335]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of autophagosome assembly [GO:2000785]; regulation of blood coagulation [GO:0030193]; retinal ganglion cell axon guidance [GO:0031290]; roof of mouth development [GO:0060021]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; urogenital system development [GO:0001655]

axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]

amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; transmembrane-ephrin receptor activity [GO:0005005]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR027936;IPR034238;IPR001090;IPR003961;IPR036116;IPR008979;IPR009030;IPR013783;IPR011009;IPR000719;IPR017441;IPR001660;IPR013761;IPR001245;IPR011641;IPR008266;IPR020635;IPR016257;IPR001426;

2.60.40.1770;2.60.120.260;2.60.40.10;1.10.150.50;1.10.510.10;2.10.50.10;

A0A5F5PPC4

MAGSALWFFLLLAAALAGRATALWPWPQYIQTSDLRYPIFPHNFQFQYHVSSAAQPGCSVLDEAFQRYRDLLFGSDFWHRPDPAEKQHTLEINSLVIHVATPGCDQLPSLESAENYTLTINDEQNFLFSETVWGALRGLETFSQLVWRSPEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILNTLDVMAYSKFNVFHWHMVDDPSFPYESFTFPELTRKGSYNPATHIYTAQDVKEVIEYARLRGIRVLVEFDTPGHTQSWGPGAPGLLTPCYSGSQPSGTFGPVNPILNSTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFSCWKSNPDIQDFMKKKGFGNDFKKLESFYIQTLLDIVSAYGKGYVVWQEVFDNKVKVRPDTIIQVWREEAPVSYMKELELVTNASFRALLSAPWYLNHITYGPDWEKVYMVEPLAFDGTPEQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAVAERLWSSKLVTNLDFASKRLADFRCELLRRGIQAQPLNVGYCEQEFEET

Equus caballus (Horse)

3.2.1.52

CATALYTIC ACTIVITY: Reaction=H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine; Xref=Rhea:RHEA:64384, ChEBI:CHEBI:15377, ChEBI:CHEBI:152567, ChEBI:CHEBI:152568, ChEBI:CHEBI:153064; Evidence={ECO:0000256|ARBA:ARBA00023541}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64385; Evidence={ECO:0000256|ARBA:ARBA00023541}; CATALYTIC ACTIVITY: Reaction=H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:48276, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:90163, ChEBI:CHEBI:90164; Evidence={ECO:0000256|ARBA:ARBA00023953}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48277; Evidence={ECO:0000256|ARBA:ARBA00023953}; CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; Evidence={ECO:0000256|ARBA:ARBA00001231, ECO:0000256|PIRNR:PIRNR001093}; CATALYTIC ACTIVITY: Reaction=a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:47940, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:60065, ChEBI:CHEBI:71502; Evidence={ECO:0000256|ARBA:ARBA00043767}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47941; Evidence={ECO:0000256|ARBA:ARBA00043767}; CATALYTIC ACTIVITY: Reaction=a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:47968, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:79210, ChEBI:CHEBI:79218; Evidence={ECO:0000256|ARBA:ARBA00043827}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47969; Evidence={ECO:0000256|ARBA:ARBA00043827}; CATALYTIC ACTIVITY: Reaction=beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine; Xref=Rhea:RHEA:64372, ChEBI:CHEBI:15377, ChEBI:CHEBI:28037, ChEBI:CHEBI:152565, ChEBI:CHEBI:152566; Evidence={ECO:0000256|ARBA:ARBA00023505}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64373; Evidence={ECO:0000256|ARBA:ARBA00023505};

Disulfide bond;Glycosidase;Hydrolase;Lysosome;Proteomics identification;Reference proteome;Signal;Zymogen

adult walking behavior [GO:0007628]; carbohydrate metabolic process [GO:0005975]; cell morphogenesis involved in neuron differentiation [GO:0048667]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; lipid storage [GO:0019915]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; sensory perception of sound [GO:0007605]; sexual reproduction [GO:0019953]; skeletal system development [GO:0001501]

azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cytosol [GO:0005829]; lysosome [GO:0005764]; membrane [GO:0016020]

acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; protein heterodimerization activity [GO:0046982]

SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.

IPR025705;IPR015883;IPR017853;IPR029018;IPR029019;

3.30.379.10;3.20.20.80;

A0A5F5PPX3

MKKSRSVMAVTADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGVPRPTTLPLTTLPSIAITTVSQERFDVENGPSPGRSPLDPQASSSSGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVHLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPESRDSLGETGVDMATEDKSPVDT

Equus caballus (Horse)

3.1.4.-

CATALYTIC ACTIVITY: Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence={ECO:0000256|ARBA:ARBA00033681}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence={ECO:0000256|ARBA:ARBA00033681};

COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000256|RuleBase:RU363067}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};

PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004703}.

cAMP;cGMP;Hydrolase;Metal-binding;Reference proteome

cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; neutrophil homeostasis [GO:0001780]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of type II interferon production [GO:0032729]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell contraction [GO:0086004]; T cell receptor signaling pathway [GO:0050852]

centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; gamma-tubulin complex [GO:0000930]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]

3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calcium channel regulator activity [GO:0005246]; cAMP binding [GO:0030552]; gamma-tubulin binding [GO:0043015]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]

IPR003607;IPR040844;IPR023088;IPR002073;IPR036971;IPR023174;

1.10.1300.10;

A0A5F5PVI1

MGGQCAEGWTQLSLLCDRAHHVALVGSACPGVKCGQCRLPVALTERAAMEEVVIAGMSGRLPESENMQEFWANLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPALLRGTHTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDLKGPSITLDTACSSSLLALHNAYQAIRSGECPAAIVGGINVLLKPNTSVQFMKLGMLSPEGACKSFDEAGNGYCRSEAVVAVLLTKKSLARRVYATILNSGTNTDGSKEQGVTFPSGDAQEQLMSSLYKPAGVAPESLEYLEAHGTGTRVGDPQELKGVVRALCATRQDPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALRDGRLQVVDRPLPIRGGNVGINSFGFGGSNVHVILQPNSRLPLVPTPHVALPCLLRASGRTSEAVLGLLEQGRQHSQDLAFVSMLNDIAATPPSAMPFRGYAVLGGEGDAQEVQQVSTGQRPLWFICSGMGAQWRGMGLSLMRLGTFRDSILRSDKAVKPLGLQVSDLLLSADEATFDDTVPGFVSLTAIQIALIDLLTSMGLRPDGIIGHSLGEVACGYADGCVSQEEAILAAYWRGQCIKEANIPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAAVSEFVEQLKQEGVFAKEVRTGGLAFHSYFMDSISHTLLQALKKVIREPRPRSVRWLSTSIPEAQWQSSLARTFSAEYNVNNLVSPVLFQEALCHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIVPLMKKDHRDNLEFFLSNVGRLHLMGIDVNPNGLFPPVEFPAPRGTPLISPHIKWDHSQTWYVPSAKDFPSGSSCSSSTVYNIDASPESPDHYLVDHCIDGRTLFPATGYLCLVWRTLAHALGENLEQMPVVFEDVTLYQATILPKTGTMPLEVRLLEASHTFEVSENGTLIVSGKVYQWDNPNPKLFDNRDSLDPADPTDPTATFHLAQGDVYKELRLRGYDYGPHFQGILKANLEGNTGQLLWKDNWVTFLDTMLQMSILGSAQRSLRLPTRIAAIHIDPATHQQKVYTLQGEAQVADLVVDSCLSSTVAGGAIISRLHTSLAPRRQQEQLAPTLEKFCFTPHVEGGCLAGSATLQEELQLCKGLAQALQVKVAQQGLKMVVPGLDGAQVPRESPQQGLPRLLAAACQLQLNGNLQLELGQVLAQESPLLCDDPLLSGLLDSPALKACVDTALENVASLRMKVVEVLAGDGHLYSRIPALLTTQPMLQLDYTATDRHAQALKAAQAKLQQHHVAQGQWDPMDPAPSSLGATDLLVCNCAVATLGDPATALGNMAAVLKEGGFLLLHTLLRGYPLGEMVAFLTCPEPQRGRQGLLSQDEWESLFAGASLRLVALKKSFYGSVLFLCRRPAPQDSPIFLPVEDMSFRWVDSLKNILADLSSRPVWLTAVSCSTSGVIGMANCLRKEPGGHRIRCILVSNLSNTSPVPKMDPSSSELQKVLQGDLVMNVYRDGAWGTFRHFPLEQDQPEEQTEHAFINVLTRGDLSSIRWVCSPLRHAQHPGPGLQLCTVYYASLNFRDIMLATGKLSPDAIPGKWAARDCMLGMEFSGRDASGKRVMGLVPAEGLATSVLLSQDFLWDVPSCWTLEEAASVPVVYTTAYYSLVVRGRVRRGETVLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLNDTSFANSRDTSFEQHVLRHTAGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAVFLKNVTFHGILLDALFDETSSDWQEVVALVRAGIQDGVVQPLKCTVFPKTQVEDAFRYMAQGKHIGKVVVQVREEEPEAVLQEVKPTRMVALSKTFFPAHKSYVVVGGLGGFGLELAQWLVLRGAQKLVLTSRSGIRTGYQAKQVREWRRQGVQVLVSTCNASSLDGARGLIAEAAQLGPVGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRVTRETCPELDYFVAFSSVSCGRGNAGQTNYGFANSTMERICEKRRHDGLPGLAVQWGAIGDVGIILEAMGANDTVIGGTLPQRIASCLEVLDLFLNQPHPVLSSFVLAEKKAAAHSDSSSQQDLVKAVAHILGIQDLATINLDSSLVDLGLDSLMGVEVRQTLEREHDMVLSMRDIQQLTLRKLQELSSQTCMADELAAPTPKEDGLTRQQAQLNLSTLLVNPEAPTLTRLNSVQSSERPLFLVHPIEGSITVFHSLATKLSIPTYGLQCTKAAPLDSIQSLAAYYIECIRQVQPEGPYRIAGYSYGACVAFEMCSQLQAQQSSAPAHNSLFLFDGSHAYVLAYTQSYRAKLTPGCEAEAETEAMCFFIQQFTDAEHSRVLEALLPLKGLEERVVAAVDLIVQNHAGLDRRVLSFAARSFYYKLRAAEQYMPRATYHGNVTLLRAKTGSAYSEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESILSIIHSSLAEPRVSVREG

Equus caballus (Horse)

FUNCTION: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000256|ARBA:ARBA00023442}.

1.1.1.100; 1.3.1.39; 2.3.1.38; 2.3.1.39; 2.3.1.41; 2.3.1.85; 3.1.2.14; 4.2.1.59

CATALYTIC ACTIVITY: Reaction=(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41812, Rhea:RHEA-COMP:9627, Rhea:RHEA-COMP:9628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78453, ChEBI:CHEBI:78454; Evidence={ECO:0000256|ARBA:ARBA00023357}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41813; Evidence={ECO:0000256|ARBA:ARBA00023357}; CATALYTIC ACTIVITY: Reaction=(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41864, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78467, ChEBI:CHEBI:78468; Evidence={ECO:0000256|ARBA:ARBA00023387}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41865; Evidence={ECO:0000256|ARBA:ARBA00023387}; CATALYTIC ACTIVITY: Reaction=(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41880, Rhea:RHEA-COMP:9643, Rhea:RHEA-COMP:9644, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:65264, ChEBI:CHEBI:78472; Evidence={ECO:0000256|ARBA:ARBA00023385}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41881; Evidence={ECO:0000256|ARBA:ARBA00023385}; CATALYTIC ACTIVITY: Reaction=(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41912, Rhea:RHEA-COMP:9651, Rhea:RHEA-COMP:9652, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78481, ChEBI:CHEBI:78483; Evidence={ECO:0000256|ARBA:ARBA00023345}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41913; Evidence={ECO:0000256|ARBA:ARBA00023345}; CATALYTIC ACTIVITY: Reaction=(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41832, Rhea:RHEA-COMP:9631, Rhea:RHEA-COMP:9632, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78458, ChEBI:CHEBI:78459; Evidence={ECO:0000256|ARBA:ARBA00023359}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41833; Evidence={ECO:0000256|ARBA:ARBA00023359}; CATALYTIC ACTIVITY: Reaction=(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]; Xref=Rhea:RHEA:41928, Rhea:RHEA-COMP:9655, Rhea:RHEA-COMP:9656, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78489, ChEBI:CHEBI:78495; Evidence={ECO:0000256|ARBA:ARBA00023376}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41929; Evidence={ECO:0000256|ARBA:ARBA00023376}; CATALYTIC ACTIVITY: Reaction=(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]; Xref=Rhea:RHEA:41848, Rhea:RHEA-COMP:9635, Rhea:RHEA-COMP:9636, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78462, ChEBI:CHEBI:78463; Evidence={ECO:0000256|ARBA:ARBA00023420}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41849; Evidence={ECO:0000256|ARBA:ARBA00023420}; CATALYTIC ACTIVITY: Reaction=(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]; Xref=Rhea:RHEA:41896, Rhea:RHEA-COMP:9647, Rhea:RHEA-COMP:9648, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78475, ChEBI:CHEBI:78477; Evidence={ECO:0000256|ARBA:ARBA00023368}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41897; Evidence={ECO:0000256|ARBA:ARBA00023368}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41808, Rhea:RHEA-COMP:9626, Rhea:RHEA-COMP:9627, ChEBI:CHEBI:15377, ChEBI:CHEBI:78451, ChEBI:CHEBI:78453; Evidence={ECO:0000256|ARBA:ARBA00023402}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41809; Evidence={ECO:0000256|ARBA:ARBA00023402}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639, ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467; Evidence={ECO:0000256|ARBA:ARBA00023388}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41861; Evidence={ECO:0000256|ARBA:ARBA00023388}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41876, Rhea:RHEA-COMP:9642, Rhea:RHEA-COMP:9643, ChEBI:CHEBI:15377, ChEBI:CHEBI:78470, ChEBI:CHEBI:78472; Evidence={ECO:0000256|ARBA:ARBA00023351}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41877; Evidence={ECO:0000256|ARBA:ARBA00023351}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41908, Rhea:RHEA-COMP:9650, Rhea:RHEA-COMP:9651, ChEBI:CHEBI:15377, ChEBI:CHEBI:78480, ChEBI:CHEBI:78481; Evidence={ECO:0000256|ARBA:ARBA00023401}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41909; Evidence={ECO:0000256|ARBA:ARBA00023401}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41828, Rhea:RHEA-COMP:9630, Rhea:RHEA-COMP:9631, ChEBI:CHEBI:15377, ChEBI:CHEBI:78457, ChEBI:CHEBI:78458; Evidence={ECO:0000256|ARBA:ARBA00023373}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41829; Evidence={ECO:0000256|ARBA:ARBA00023373}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41924, Rhea:RHEA-COMP:9654, Rhea:RHEA-COMP:9655, ChEBI:CHEBI:15377, ChEBI:CHEBI:78488, ChEBI:CHEBI:78489; Evidence={ECO:0000256|ARBA:ARBA00023399}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41925; Evidence={ECO:0000256|ARBA:ARBA00023399}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41844, Rhea:RHEA-COMP:9634, Rhea:RHEA-COMP:9635, ChEBI:CHEBI:15377, ChEBI:CHEBI:78461, ChEBI:CHEBI:78462; Evidence={ECO:0000256|ARBA:ARBA00023332}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41845; Evidence={ECO:0000256|ARBA:ARBA00023332}; CATALYTIC ACTIVITY: Reaction=(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41892, Rhea:RHEA-COMP:9646, Rhea:RHEA-COMP:9647, ChEBI:CHEBI:15377, ChEBI:CHEBI:78474, ChEBI:CHEBI:78475; Evidence={ECO:0000256|ARBA:ARBA00023398}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41893; Evidence={ECO:0000256|ARBA:ARBA00023398}; CATALYTIC ACTIVITY: Reaction=3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41804, Rhea:RHEA-COMP:9625, Rhea:RHEA-COMP:9626, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78450, ChEBI:CHEBI:78451; Evidence={ECO:0000256|ARBA:ARBA00023413}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41805; Evidence={ECO:0000256|ARBA:ARBA00023413}; CATALYTIC ACTIVITY: Reaction=3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41856, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9638, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78464, ChEBI:CHEBI:78466; Evidence={ECO:0000256|ARBA:ARBA00023418}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41857; Evidence={ECO:0000256|ARBA:ARBA00023418}; CATALYTIC ACTIVITY: Reaction=3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41872, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9642, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78469, ChEBI:CHEBI:78470; Evidence={ECO:0000256|ARBA:ARBA00023416}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41873; Evidence={ECO:0000256|ARBA:ARBA00023416}; CATALYTIC ACTIVITY: Reaction=3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41904, Rhea:RHEA-COMP:9649, Rhea:RHEA-COMP:9650, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78478, ChEBI:CHEBI:78480; Evidence={ECO:0000256|ARBA:ARBA00023390}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41905; Evidence={ECO:0000256|ARBA:ARBA00023390}; CATALYTIC ACTIVITY: Reaction=3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41824, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9630, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78456, ChEBI:CHEBI:78457; Evidence={ECO:0000256|ARBA:ARBA00023346}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41825; Evidence={ECO:0000256|ARBA:ARBA00023346}; CATALYTIC ACTIVITY: Reaction=3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41920, Rhea:RHEA-COMP:9653, Rhea:RHEA-COMP:9654, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78487, ChEBI:CHEBI:78488; Evidence={ECO:0000256|ARBA:ARBA00023419}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41921; Evidence={ECO:0000256|ARBA:ARBA00023419}; CATALYTIC ACTIVITY: Reaction=3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41840, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9634, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78460, ChEBI:CHEBI:78461; Evidence={ECO:0000256|ARBA:ARBA00023364}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41841; Evidence={ECO:0000256|ARBA:ARBA00023364}; CATALYTIC ACTIVITY: Reaction=3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+); Xref=Rhea:RHEA:41888, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9646, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78473, ChEBI:CHEBI:78474; Evidence={ECO:0000256|ARBA:ARBA00023367}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41889; Evidence={ECO:0000256|ARBA:ARBA00023367}; CATALYTIC ACTIVITY: Reaction=H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41916, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9652, Rhea:RHEA-COMP:9653, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78483, ChEBI:CHEBI:78487; Evidence={ECO:0000256|ARBA:ARBA00023365}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41917; Evidence={ECO:0000256|ARBA:ARBA00023365}; CATALYTIC ACTIVITY: Reaction=H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9632, Rhea:RHEA-COMP:9633, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78459, ChEBI:CHEBI:78460; Evidence={ECO:0000256|ARBA:ARBA00023361}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41837; Evidence={ECO:0000256|ARBA:ARBA00023361}; CATALYTIC ACTIVITY: Reaction=H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41852, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9636, Rhea:RHEA-COMP:9637, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78463, ChEBI:CHEBI:78464; Evidence={ECO:0000256|ARBA:ARBA00023414}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41853; Evidence={ECO:0000256|ARBA:ARBA00023414}; CATALYTIC ACTIVITY: Reaction=H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41900, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9649, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78477, ChEBI:CHEBI:78478; Evidence={ECO:0000256|ARBA:ARBA00023341}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41901; Evidence={ECO:0000256|ARBA:ARBA00023341}; CATALYTIC ACTIVITY: Reaction=H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]; Xref=Rhea:RHEA:41932, Rhea:RHEA-COMP:9652, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64479, ChEBI:CHEBI:78483; EC=3.1.2.14; Evidence={ECO:0000256|ARBA:ARBA00023378}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41933; Evidence={ECO:0000256|ARBA:ARBA00023378}; CATALYTIC ACTIVITY: Reaction=H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate; Xref=Rhea:RHEA:30123, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:64479, ChEBI:CHEBI:78477; EC=3.1.2.14; Evidence={ECO:0000256|ARBA:ARBA00023410}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30124; Evidence={ECO:0000256|ARBA:ARBA00023410}; CATALYTIC ACTIVITY: Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100; Evidence={ECO:0000256|ARBA:ARBA00023333}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17399; Evidence={ECO:0000256|ARBA:ARBA00023333}; CATALYTIC ACTIVITY: Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59; Evidence={ECO:0000256|ARBA:ARBA00023394}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13098; Evidence={ECO:0000256|ARBA:ARBA00023394}; CATALYTIC ACTIVITY: Reaction=a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH; Xref=Rhea:RHEA:22564, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.39; Evidence={ECO:0000256|ARBA:ARBA00023381}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22566; Evidence={ECO:0000256|ARBA:ARBA00023381}; CATALYTIC ACTIVITY: Reaction=a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:22836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776, ChEBI:CHEBI:138651; EC=2.3.1.41; Evidence={ECO:0000256|ARBA:ARBA00023389}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22837; Evidence={ECO:0000256|ARBA:ARBA00023389}; CATALYTIC ACTIVITY: Reaction=acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+); Xref=Rhea:RHEA:14993, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:57560, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=2.3.1.85; Evidence={ECO:0000256|ARBA:ARBA00023370}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14994; Evidence={ECO:0000256|ARBA:ARBA00023370}; CATALYTIC ACTIVITY: Reaction=acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA; Xref=Rhea:RHEA:41788, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64479, ChEBI:CHEBI:78446; EC=2.3.1.38; Evidence={ECO:0000256|ARBA:ARBA00023397}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41789; Evidence={ECO:0000256|ARBA:ARBA00023397}; CATALYTIC ACTIVITY: Reaction=acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41800, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9625, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78446, ChEBI:CHEBI:78449, ChEBI:CHEBI:78450; Evidence={ECO:0000256|ARBA:ARBA00023352}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41801; Evidence={ECO:0000256|ARBA:ARBA00023352}; CATALYTIC ACTIVITY: Reaction=butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41820, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9628, Rhea:RHEA-COMP:9629, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78454, ChEBI:CHEBI:78456; Evidence={ECO:0000256|ARBA:ARBA00023403}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41821; Evidence={ECO:0000256|ARBA:ARBA00023403}; CATALYTIC ACTIVITY: Reaction=decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41868, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9640, Rhea:RHEA-COMP:9641, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78468, ChEBI:CHEBI:78469; Evidence={ECO:0000256|ARBA:ARBA00023396}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41869; Evidence={ECO:0000256|ARBA:ARBA00023396}; CATALYTIC ACTIVITY: Reaction=dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:41884, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9644, Rhea:RHEA-COMP:9645, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:65264, ChEBI:CHEBI:78449, ChEBI:CHEBI:78473; Evidence={ECO:0000256|ARBA:ARBA00023348}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41885; Evidence={ECO:0000256|ARBA:ARBA00023348}; CATALYTIC ACTIVITY: Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]; Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449; EC=2.3.1.39; Evidence={ECO:0000256|ARBA:ARBA00023404}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41793; Evidence={ECO:0000256|ARBA:ARBA00023404};

PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|ARBA:ARBA00005194}.

Acetylation;Fatty acid biosynthesis;Fatty acid metabolism;Hydrolase;Lipid biosynthesis;Lipid metabolism;Lyase;Multifunctional enzyme;NAD;NADP;Phosphopantetheine;Phosphoprotein;Proteomics identification;Pyridoxal phosphate;Reference proteome;S-nitrosylation;Transferase

fatty acid biosynthetic process [GO:0006633]

cytoplasm [GO:0005737]

(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity [GO:0047117]; fatty acid synthase activity [GO:0004312]; fatty acyl-[ACP] hydrolase activity [GO:0016297]; phosphopantetheine binding [GO:0031177]

IPR029058;IPR001227;IPR036736;IPR014043;IPR016035;IPR049391;IPR011032;IPR018201;IPR014031;IPR014030;IPR016036;IPR013217;IPR036291;IPR032821;IPR020841;IPR042104;IPR020807;IPR049552;IPR020843;IPR013968;IPR049900;IPR020806;IPR009081;IPR006162;IPR029063;IPR001031;IPR016039;

3.30.70.3290;3.40.47.10;1.10.1200.10;3.40.50.1820;3.40.366.10;3.90.180.10;3.40.50.720;3.10.129.110;3.40.50.150;

A0A5F5PWH6

MGEPGSLVRGDRAGGRSWCLRRVGMNAEWLLLEDGDEVTVGRGFGVTYQLVSKICPLMISRNHCVLKQNAEGQWTIMDNKSLNGVWLNRERLEPLEVYSIRKGDHIQLGVPLENKENAEYEYEVIEEDWERIYPCLAPKNDHIIGKNKGLRTKRKFSLDELEGLGAEGPSNLKCKISKVSCEPGQPVKSSGKSEVASHPPEYLDPKLTSLEPSEKTTGAHVSPGPVEVVELQQKKQKKTSNPSASQSSLDLFRVTMSRILKLKTQMQEKQVAVLNVKKQTQEGNSKMIVKMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEKEQGEEDLKQQLAQALQEHQALMEELNRSKKDFEAILQAKNKELEQTKEEKEKVQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAHSFCSYCINEWMKRKIECPICRKDIKSKTHSLVLDNCINKMVDNLSSEVKERRIVLIRERKGEWV

Equus caballus (Horse)

FUNCTION: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2. {ECO:0000256|HAMAP-Rule:MF_03067}.

2.3.2.27

CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000256|HAMAP-Rule:MF_03067};

PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|HAMAP-Rule:MF_03067, ECO:0000256|PIRNR:PIRNR037950}.

Cell cycle;Cell division;Chromatin regulator;Chromosome;Coiled coil;Cytoplasm;DNA damage;DNA repair;Metal-binding;Mitosis;Nucleus;Reference proteome;Telomere;Transferase;Ubl conjugation;Ubl conjugation pathway;Zinc;Zinc-finger

cell cycle [GO:0007049]; cell division [GO:0051301]; chromatin organization [GO:0006325]; double-strand break repair [GO:0006302]; positive regulation of DNA repair [GO:0045739]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511]

cell division site [GO:0032153]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]

chromatin binding [GO:0003682]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]

SUBCELLULAR LOCATION: Nucleus {ECO:0000256|HAMAP-Rule:MF_03067}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03067}. Midbody {ECO:0000256|HAMAP-Rule:MF_03067}. Chromosome, telomere {ECO:0000256|HAMAP-Rule:MF_03067}. Note=Recruited at uncapped telomeres. Following DNA double-strand breaks, recruited to the sites of damage. During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1. {ECO:0000256|HAMAP-Rule:MF_03067}.

PTM: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger. {ECO:0000256|HAMAP-Rule:MF_03067}.

DOMAIN: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2. {ECO:0000256|HAMAP-Rule:MF_03067}.

IPR000253;IPR017335;IPR008984;IPR001841;IPR013083;IPR017907;

1.20.5.170;2.60.200.20;3.30.40.10;

A0A5F5PYR0

MTAPWAALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIILLAFWMYRHRKPPYGHVDIHEVRWLVWGRAGVEMGRPGQTLLSPGLPQDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPAIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI

Equus caballus (Horse)

2.7.11.30

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023945}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023948, ECO:0000256|RuleBase:RU361271};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU361271}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|RuleBase:RU361271};

ATP-binding;Disulfide bond;Kinase;Magnesium;Manganese;Membrane;Metal-binding;Nucleotide-binding;Receptor;Reference proteome;Serine/threonine-protein kinase;Signal;Transferase;Transmembrane;Transmembrane helix

activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic foregut morphogenesis [GO:0048617]; gastrulation with mouth forming second [GO:0001702]; heart development [GO:0007507]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; organ growth [GO:0035265]; pancreas development [GO:0031016]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; response to glucose [GO:0009749]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; venous blood vessel development [GO:0060841]

activin receptor complex [GO:0048179]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]

activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; protein serine/threonine/tyrosine kinase activity [GO:0004712]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.

IPR000472;IPR011009;IPR000719;IPR008271;IPR045860;IPR000333;

2.10.60.10;1.10.510.10;

A0A5F5PZU2

MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

Equus caballus (Horse)

2.7.11.1

ATP-binding;Kinase;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc

death-inducing signaling complex assembly [GO:0071550]; ERBB2-ERBB3 signaling pathway [GO:0038133]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; face development [GO:0060324]; insulin receptor signaling pathway [GO:0008286]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intermediate filament cytoskeleton organization [GO:0045104]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of protein-containing complex assembly [GO:0031333]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphorylation [GO:0016310]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; response to muscle stretch [GO:0035994]; Schwann cell development [GO:0014044]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; type B pancreatic cell proliferation [GO:0044342]

cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.

IPR046349;IPR020454;IPR011009;IPR002219;IPR000719;IPR017441;IPR003116;IPR008271;IPR029071;

3.30.60.20;1.10.510.10;

A0A5F5Q268

MPTVISASVASRTGAEPMSPGPVAHPAQGSTTESGGGNPSGNYSAIISRNFPIIGVKEKTFEKLHKKCLEKNVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICKNPRFIIGGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKEAPRDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLKMGDLIARMVRNMDNSRLRDSDLIPRDSDDRPTRTIVPVQYETRMACGLVRGHAYSVIGLEEAWFKNEKVKLVRLRNPWGQVEWNGSWSDGWKDWSFVDKEEKARLQHQVTEDGEFWMSYDDFIYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPEDSEVICSFLVALMQKNRRKNRKLGANLFTIGFAIYEVPKEMHGNRQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKDKTSPDKQERSPQPQPGITDQESEEQQQFYNIFRQIAGDDMEISADELKNILNTVVNRHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWNKIKTWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNRQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA

Equus caballus (Horse)

FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000256|RuleBase:RU367132}.

3.4.22.54

CATALYTIC ACTIVITY: Reaction=Broad endopeptidase activity.; EC=3.4.22.54; Evidence={ECO:0000256|ARBA:ARBA00023702, ECO:0000256|RuleBase:RU367132};

Calcium;Cytoplasm;Hydrolase;Metal-binding;Nucleus;Protease;Reference proteome;Repeat;Thiol protease

calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; programmed cell death [GO:0012501]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of myoblast differentiation [GO:0045661]; sarcomere organization [GO:0045214]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]

calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; ligase regulator activity [GO:0055103]; molecular adaptor activity [GO:0060090]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU367132}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.

IPR033883;IPR022684;IPR022682;IPR022683;IPR036213;IPR029531;IPR011992;IPR018247;IPR002048;IPR038765;IPR000169;IPR001300;

2.60.120.380;3.90.70.10;1.10.238.10;

A0A5F5Q3G5

MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTIQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGRETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDTTLPLLLDSLQKMQEEMIKALKSIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDISLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSKTYEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFTAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSAPGSSTFCDAIPISEKPLAEQDWYHGAIPRIEAQDLLKQQGDFLVRESHGKPGEYVLSVFSDGQRRHFIIQFVDVCNYFCNPRFIICMNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWVLNHEDVTLGELLGKGNFGEVYKGILKDKTAVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPIYIIMELVPGGDFLSFLRKKKDEIKLKQLVKFALDAASGMSYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDVFKIMMKCWDYKPENRPKFGELQKELTVIKKKIT

Equus caballus (Horse)

2.7.10.2

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000256|ARBA:ARBA00001149, ECO:0000256|PIRNR:PIRNR000632};

ATP-binding;Coiled coil;Cytoplasm;Cytoskeleton;Kinase;Lipid-binding;Nucleotide-binding;Reference proteome;SH2 domain;Transferase;Tyrosine-protein kinase

actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; insulin receptor signaling pathway [GO:0008286]; interleukin-6-mediated signaling pathway [GO:0070102]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; phosphorylation [GO:0016310]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; substrate adhesion-dependent cell spreading [GO:0034446]

actin cytoskeleton [GO:0015629]; cell junction [GO:0030054]; chromatin [GO:0000785]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]

ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; lipid binding [GO:0008289]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein phosphatase 1 binding [GO:0008157]; protein tyrosine kinase activity [GO:0004713]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton {ECO:0000256|PIRNR:PIRNR000632}.

IPR027267;IPR031160;IPR001060;IPR037452;IPR035849;IPR011009;IPR000719;IPR017441;IPR001245;IPR000980;IPR036860;IPR016250;IPR008266;IPR020635;

1.20.1270.60;1.10.287.160;3.30.505.10;1.10.510.10;

A0A5F5XBZ5

MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAEKLKDYLRNKEKHGKKPVKENQSESKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPEAMEMTWMDVPGDKLLEPVVCMVSSRLGQGLHRDQKTGALGLKISSPSLSWAVVPPPKQNGRWGSG

Felis catus (Cat) (Felis silvestris catus)

3.6.4.6

ATP-binding;Nucleotide-binding;Reference proteome

abscission [GO:0009838]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; intracellular cholesterol transport [GO:0032367]; late endosomal microautophagy [GO:0061738]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; negative regulation of cytokinesis [GO:0032466]; nucleus organization [GO:0006997]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; protein targeting to lysosome [GO:0006622]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]

centrosome [GO:0005813]; cytosol [GO:0005829]; early endosome [GO:0005769]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774]

ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein-containing complex binding [GO:0044877]

SUBCELLULAR LOCATION: Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004633}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR003593;IPR041569;IPR003959;IPR003960;IPR007330;IPR036181;IPR027417;IPR015415;IPR045253;

1.10.8.60;3.40.50.300;1.20.58.80;

A0A5F5XC40

MLEAPPLLLAAFSLGLVLLVLLLCHSYSGFLLICWNEFVLQPLYNLFMGDTKEQRILRHVLQHAVAGDPQSVLEAIDTYCLQKEWAMNVGDKKGQILDAVVREQRPSVLLELGAYCGYSAVRMARLLEPGARLLTIELNPDYAAITQQMLDFAGLQDRVTVVAGPSQDIIPQLKKKYDVDMLDMVFLDHWKDRYLPDTLLLEPLTLLLGQPQSGDQGGCLIPRSVACYGRGQCCWPTTLSAQEHQNSWHMCATAAALSAHTSPRTWSTRQQWMASRRLSTWAWMAQHSLDHPPCSRLPCQAWL

Felis catus (Cat) (Felis silvestris catus)

2.1.1.6

CATALYTIC ACTIVITY: Reaction=a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17877, ChEBI:CHEBI:15378, ChEBI:CHEBI:33566, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:134251; EC=2.1.1.6; Evidence={ECO:0000256|ARBA:ARBA00001722}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17878; Evidence={ECO:0000256|ARBA:ARBA00001722};

Acetylation;Catecholamine metabolism;Methyltransferase;Neurotransmitter degradation;Reference proteome;S-adenosyl-L-methionine;Transferase

artery development [GO:0060840]; behavioral fear response [GO:0001662]; catecholamine catabolic process [GO:0042424]; cellular response to cocaine [GO:0071314]; cellular response to phosphate starvation [GO:0016036]; cerebellar cortex morphogenesis [GO:0021696]; cholesterol efflux [GO:0033344]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; dopamine secretion [GO:0014046]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; glomerulus development [GO:0032835]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; mastication [GO:0071626]; memory [GO:0007613]; methylation [GO:0032259]; multicellular organism growth [GO:0035264]; norepinephrine metabolic process [GO:0042415]; norepinephrine secretion [GO:0048243]; prostaglandin metabolic process [GO:0006693]; renal albumin absorption [GO:0097018]; renal filtration [GO:0097205]; renal sodium excretion [GO:0035812]; renin secretion into blood stream [GO:0002001]; response to amphetamine [GO:0001975]; response to angiotensin [GO:1990776]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to dopamine [GO:1903350]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to oxidative stress [GO:0006979]; response to salt [GO:1902074]; response to toxic substance [GO:0009636]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; startle response [GO:0001964]; synaptic transmission, dopaminergic [GO:0001963]; visual learning [GO:0008542]

axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; synapse [GO:0045202]; vesicle [GO:0031982]

catechol O-methyltransferase activity [GO:0016206]

IPR029063;IPR002935;

3.40.50.150;

A0A5F5XDZ0

MILASGARGPGFKSRTSPASVLARKASAAGAWRAGTAPGVQADLRPRQASGEPGTALLPPFPPRMAQKENAYPWPYGRQTTQPGLNTLPQRVLRKEPATPSALVLMSRSNTQPTAAPGQKVVENSSGTPNFSMRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELADALLYCHGKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRTHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPPSVPTGAQDLISKLLKHNPSERLPLAQVSAHPWVRAHSRRVLPPSALQSVP

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433, ECO:0000256|RuleBase:RU367134}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775, ECO:0000256|RuleBase:RU367134};

ATP-binding;Cell cycle;Cell division;Cytoplasm;Cytoskeleton;Kinase;Mitosis;Nucleotide-binding;Nucleus;Reference proteome;Serine/threonine-protein kinase;Transferase

cell cycle G2/M phase transition [GO:0044839]; cellular response to UV [GO:0034644]; cleavage furrow formation [GO:0036089]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphorylation [GO:0016310]; positive regulation of cytokinesis [GO:0032467]; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore [GO:1905116]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-translational protein modification [GO:0043687]; protein localization to kinetochore [GO:0034501]; regulation of cytokinesis [GO:0032465]

chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; kinetochore [GO:0000776]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; nucleoplasm [GO:0005654]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole centrosome [GO:0031616]

ATP binding [GO:0005524]; histone H3S28 kinase activity [GO:0044022]; kinase binding [GO:0019900]

SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000256|ARBA:ARBA00004584}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR030616;IPR011009;IPR000719;IPR017441;IPR008271;

1.10.510.10;

A0A5F5XEB2

MDLVRTGHAAGADVTSLGELTTQGWGEQTHDRVAPHRGFGGGAQRMGRFPKVNKRAFPEPSRCLPQPGPVWGTVRFDGGAVGAGQGPSPGRLPGGDDGDPRLGWVEHEESRLQVLVGTAGGSGRPRREKQGRSVVLARCLVNSPPHALSPPRDPATKASLSKPRRPRRCRDLPLCFLQMEMLRLGEVSWRPGGAPSDAVSSLPPPSGLSVLIRVRLELRRHQRARHTIPRIFQVVAQRQPDRLALVDAGSGVCWTFAQLDAYSNAVANLFCRLGFTPGDVVAILLEGRPEFVGLWLGLAKAGVEAALLNVNLRREPLAFCLGTSGAKALIFGGELAAAVAEVSGQLGKSLLKFCSGELGPEGILPDARLLDPLLKEASTAPLAQPPDKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHYAYSMQVADVLYDCLPLYHTAGNIMGVGQCLLYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLKQPVREAEGRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANVDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYISESATSKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRGGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHGQLSPNVLYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQHEGFDPRQTSDRLFFLDLKQGHYLPLDQSVYTRICSGAFAL

Felis catus (Cat) (Felis silvestris catus)

6.2.1.3

CATALYTIC ACTIVITY: Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036436}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence={ECO:0000256|ARBA:ARBA00036436}; CATALYTIC ACTIVITY: Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036527}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence={ECO:0000256|ARBA:ARBA00036527};

Ligase;Lipid metabolism;Reference proteome

adiponectin-activated signaling pathway [GO:0033211]; biotin import across plasma membrane [GO:1905135]; cardiolipin biosynthetic process [GO:0032049]; export across plasma membrane [GO:0140115]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to cold [GO:0009409]

basal plasma membrane [GO:0009925]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]

biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; fatty acid transmembrane transporter activity [GO:0015245]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; nucleotide binding [GO:0000166]; oleoyl-CoA ligase activity [GO:0090434]; protein serine/threonine kinase activator activity [GO:0043539]; very long-chain fatty acid-CoA ligase activity [GO:0031957]

IPR025110;IPR045851;IPR020845;IPR000873;IPR042099;

3.30.300.30;3.40.50.12780;

A0A5F5XEK3

MDENESNQSLMTSSQYPKEAVRKRQNSARSSVGSDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNLSVPNVLRWLIMEKDHSSVPCSKEELDKELPVLRPYFIDDPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPVFSSRASPSQHMGPKRFRRPPCTIGELPPIDAVLISHNHYDHLDYNSVIALNERFGQELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLVDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHIDPEEAVRIHIDVQTKKSVAIHWGTFALANEHYLEPPVKLSEALGRYGLNTEDFFVLKHGESRYLHTDDENSE

Felis catus (Cat) (Felis silvestris catus)

3.1.4.54

CATALYTIC ACTIVITY: Reaction=1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:56464, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:138663, ChEBI:CHEBI:140452; Evidence={ECO:0000256|ARBA:ARBA00044474}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56465; Evidence={ECO:0000256|ARBA:ARBA00044474}; CATALYTIC ACTIVITY: Reaction=H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine; Xref=Rhea:RHEA:45532, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71466, ChEBI:CHEBI:74546, ChEBI:CHEBI:85291; Evidence={ECO:0000256|ARBA:ARBA00023539}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45533; Evidence={ECO:0000256|ARBA:ARBA00023539}; CATALYTIC ACTIVITY: Reaction=H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+); Xref=Rhea:RHEA:53164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:52640, ChEBI:CHEBI:57970, ChEBI:CHEBI:85216; Evidence={ECO:0000256|ARBA:ARBA00023521}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53165; Evidence={ECO:0000256|ARBA:ARBA00023521}; CATALYTIC ACTIVITY: Reaction=H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:45596, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:72860, ChEBI:CHEBI:85334; Evidence={ECO:0000256|ARBA:ARBA00023516}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45597; Evidence={ECO:0000256|ARBA:ARBA00023516}; CATALYTIC ACTIVITY: Reaction=H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:45592, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:71464, ChEBI:CHEBI:85335; Evidence={ECO:0000256|ARBA:ARBA00023492}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45593; Evidence={ECO:0000256|ARBA:ARBA00023492}; CATALYTIC ACTIVITY: Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:45528, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85277; Evidence={ECO:0000256|ARBA:ARBA00023540}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45529; Evidence={ECO:0000256|ARBA:ARBA00023540}; CATALYTIC ACTIVITY: Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:56548, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58608, ChEBI:CHEBI:140532; Evidence={ECO:0000256|ARBA:ARBA00023542}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56549; Evidence={ECO:0000256|ARBA:ARBA00023542}; CATALYTIC ACTIVITY: Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine; Xref=Rhea:RHEA:45544, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74544, ChEBI:CHEBI:85223; Evidence={ECO:0000256|ARBA:ARBA00023561}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45545; Evidence={ECO:0000256|ARBA:ARBA00023561}; CATALYTIC ACTIVITY: Reaction=H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine; Xref=Rhea:RHEA:45620, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85298, ChEBI:CHEBI:85304; Evidence={ECO:0000256|ARBA:ARBA00023528}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45621; Evidence={ECO:0000256|ARBA:ARBA00023528}; CATALYTIC ACTIVITY: Reaction=H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine; Xref=Rhea:RHEA:45608, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85295, ChEBI:CHEBI:85301; Evidence={ECO:0000256|ARBA:ARBA00023560}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45609; Evidence={ECO:0000256|ARBA:ARBA00023560}; CATALYTIC ACTIVITY: Reaction=H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine; Xref=Rhea:RHEA:45556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85263, ChEBI:CHEBI:85294; Evidence={ECO:0000256|ARBA:ARBA00023499}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45557; Evidence={ECO:0000256|ARBA:ARBA00023499}; CATALYTIC ACTIVITY: Reaction=H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine; Xref=Rhea:RHEA:45540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:71464, ChEBI:CHEBI:74546, ChEBI:CHEBI:78097; Evidence={ECO:0000256|ARBA:ARBA00023534}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45541; Evidence={ECO:0000256|ARBA:ARBA00023534}; CATALYTIC ACTIVITY: Reaction=H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine; Xref=Rhea:RHEA:45616, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85297, ChEBI:CHEBI:85303; Evidence={ECO:0000256|ARBA:ARBA00023523}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45617; Evidence={ECO:0000256|ARBA:ARBA00023523}; CATALYTIC ACTIVITY: Reaction=H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine; Xref=Rhea:RHEA:45536, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85292, ChEBI:CHEBI:85299; Evidence={ECO:0000256|ARBA:ARBA00023524}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45537; Evidence={ECO:0000256|ARBA:ARBA00023524}; CATALYTIC ACTIVITY: Reaction=H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine; Xref=Rhea:RHEA:45612, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72860, ChEBI:CHEBI:85296, ChEBI:CHEBI:85302; Evidence={ECO:0000256|ARBA:ARBA00023500}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45613; Evidence={ECO:0000256|ARBA:ARBA00023500}; CATALYTIC ACTIVITY: Reaction=H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine; Xref=Rhea:RHEA:45552, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74546, ChEBI:CHEBI:85262, ChEBI:CHEBI:85293; Evidence={ECO:0000256|ARBA:ARBA00023547}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45553; Evidence={ECO:0000256|ARBA:ARBA00023547};

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|PIRSR:PIRSR038896-51}; Note=Binds 2 zinc divalent cations per subunit. {ECO:0000256|PIRSR:PIRSR038896-51};

Lipid degradation;Lipid metabolism;Metal-binding;Phospholipid degradation;Phospholipid metabolism;Reference proteome;Zinc

host-mediated regulation of intestinal microbiota composition [GO:0048874]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phospholipid catabolic process [GO:0009395]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of inflammatory response [GO:0050729]; temperature homeostasis [GO:0001659]

cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; membrane-bounded organelle [GO:0043227]

bile acid binding [GO:0032052]; identical protein binding [GO:0042802]; N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity [GO:0102200]; N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}.

IPR001279;IPR024884;IPR036866;

3.60.15.10;

A0A5F5XHD4

HKHFDDKNLRPLPAPNIKLVCCSTVGPKFTLPLIGAFWTSVTKLGLHTKPRMPPCDFTPEKYQSLAYDRVLEVHRLHLPPVPTAYFPKPLLLHQGHMQWLFDHEGNRYLDCFSGIVTVSVGHCHPKVNAVAQKQLGRLWHTSALFFHSPAHEFAEKLLALLPEPLKVIFFVNSGSEANDLAMLMARAHTNRTDLIAFRGAYHGCSPYTLGLTNVGCFRMELPSGLGCQSTMCPDVFRGPWGGSRCRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLNTSVAKSIAGFFAEPIQGVNGVVQYPKGFLKEAFKLVREREGVCIADEVQTGFGRLGSHFWAVVTTPEIAKSLAKCMYHFNTFGGSPMACAIGSAVLEVIKEENLQENSQEVGTYMLRKLAELRDEFEIVGDVRGKGLMIGIEMVKDKMGRQPLPQEEVNQIHEDCKRMGLIIGRGGIFAQTFRIAPSMCITKPDVHFAVEVFRSALIQHMERRAQQNS

Felis catus (Cat) (Felis silvestris catus)

2.6.1.18; 2.6.1.40; 2.6.1.44

CATALYTIC ACTIVITY: Reaction=(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine; Xref=Rhea:RHEA:77339, ChEBI:CHEBI:16763, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:74359; Evidence={ECO:0000256|ARBA:ARBA00043679}; CATALYTIC ACTIVITY: Reaction=(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine; Xref=Rhea:RHEA:18393, ChEBI:CHEBI:15361, ChEBI:CHEBI:57700, ChEBI:CHEBI:57731, ChEBI:CHEBI:57972; EC=2.6.1.40; Evidence={ECO:0000256|ARBA:ARBA00043726}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18394; Evidence={ECO:0000256|ARBA:ARBA00043726}; CATALYTIC ACTIVITY: Reaction=2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate; Xref=Rhea:RHEA:77355, ChEBI:CHEBI:15361, ChEBI:CHEBI:16763, ChEBI:CHEBI:57972, ChEBI:CHEBI:74359; EC=2.6.1.44; Evidence={ECO:0000256|ARBA:ARBA00043751}; CATALYTIC ACTIVITY: Reaction=2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine = (2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate; Xref=Rhea:RHEA:77351, ChEBI:CHEBI:16763, ChEBI:CHEBI:58326, ChEBI:CHEBI:74359, ChEBI:CHEBI:197301; Evidence={ECO:0000256|ARBA:ARBA00043779}; CATALYTIC ACTIVITY: Reaction=2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate; Xref=Rhea:RHEA:77363, ChEBI:CHEBI:35177, ChEBI:CHEBI:58326, ChEBI:CHEBI:58455, ChEBI:CHEBI:197301; Evidence={ECO:0000256|ARBA:ARBA00043837}; CATALYTIC ACTIVITY: Reaction=2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate; Xref=Rhea:RHEA:77359, ChEBI:CHEBI:28644, ChEBI:CHEBI:58326, ChEBI:CHEBI:58441, ChEBI:CHEBI:197301; Evidence={ECO:0000256|ARBA:ARBA00043826}; CATALYTIC ACTIVITY: Reaction=3-oxopropanoate + L-alanine = beta-alanine + pyruvate; Xref=Rhea:RHEA:14077, ChEBI:CHEBI:15361, ChEBI:CHEBI:33190, ChEBI:CHEBI:57966, ChEBI:CHEBI:57972; EC=2.6.1.18; Evidence={ECO:0000256|ARBA:ARBA00043825}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14079; Evidence={ECO:0000256|ARBA:ARBA00043825}; CATALYTIC ACTIVITY: Reaction=L-alanine + oxaloacetate = L-aspartate + pyruvate; Xref=Rhea:RHEA:77347, ChEBI:CHEBI:15361, ChEBI:CHEBI:16452, ChEBI:CHEBI:29991, ChEBI:CHEBI:57972; Evidence={ECO:0000256|ARBA:ARBA00043764}; CATALYTIC ACTIVITY: Reaction=L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77327, ChEBI:CHEBI:15361, ChEBI:CHEBI:46911, ChEBI:CHEBI:57972, ChEBI:CHEBI:58802; Evidence={ECO:0000256|ARBA:ARBA00043777}; CATALYTIC ACTIVITY: Reaction=N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77307, ChEBI:CHEBI:15361, ChEBI:CHEBI:57972, ChEBI:CHEBI:197308, ChEBI:CHEBI:197310; Evidence={ECO:0000256|ARBA:ARBA00043798}; CATALYTIC ACTIVITY: Reaction=N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate; Xref=Rhea:RHEA:77343, ChEBI:CHEBI:16452, ChEBI:CHEBI:29991, ChEBI:CHEBI:58326, ChEBI:CHEBI:197301; Evidence={ECO:0000256|ARBA:ARBA00043749}; CATALYTIC ACTIVITY: Reaction=N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77303, ChEBI:CHEBI:15361, ChEBI:CHEBI:57972, ChEBI:CHEBI:58326, ChEBI:CHEBI:197301; Evidence={ECO:0000256|ARBA:ARBA00043669}; CATALYTIC ACTIVITY: Reaction=N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine; Xref=Rhea:RHEA:77319, ChEBI:CHEBI:15361, ChEBI:CHEBI:57972, ChEBI:CHEBI:114953, ChEBI:CHEBI:197314; Evidence={ECO:0000256|ARBA:ARBA00043758}; CATALYTIC ACTIVITY: Reaction=glyoxylate + L-alanine = glycine + pyruvate; Xref=Rhea:RHEA:24248, ChEBI:CHEBI:15361, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:57972; EC=2.6.1.44; Evidence={ECO:0000256|ARBA:ARBA00033660}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24249; Evidence={ECO:0000256|ARBA:ARBA00033660}; CATALYTIC ACTIVITY: Reaction=glyoxylate + L-ornithine = 5-amino-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77331, ChEBI:CHEBI:36655, ChEBI:CHEBI:46911, ChEBI:CHEBI:57305, ChEBI:CHEBI:58802; Evidence={ECO:0000256|ARBA:ARBA00043808}; CATALYTIC ACTIVITY: Reaction=glyoxylate + N(omega),N('omega)-dimethyl-L-arginine = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77315, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:197308, ChEBI:CHEBI:197310; Evidence={ECO:0000256|ARBA:ARBA00043659}; CATALYTIC ACTIVITY: Reaction=glyoxylate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77311, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:58326, ChEBI:CHEBI:197301; Evidence={ECO:0000256|ARBA:ARBA00043815}; CATALYTIC ACTIVITY: Reaction=glyoxylate + N(omega)-methyl-L-arginine = 5-(3-methylguanidino)-2-oxopentanoate + glycine; Xref=Rhea:RHEA:77323, ChEBI:CHEBI:36655, ChEBI:CHEBI:57305, ChEBI:CHEBI:114953, ChEBI:CHEBI:197314; Evidence={ECO:0000256|ARBA:ARBA00043652};

COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000256|ARBA:ARBA00001933};

Pyridoxal phosphate;Reference proteome

glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; L-alanine catabolic process, by transamination [GO:0019481]; positive regulation of nitric oxide biosynthetic process [GO:0045429]

mitochondrion [GO:0005739]

(R)-3-amino-2-methylpropionate-pyruvate transaminase activity [GO:0047305]; alanine-glyoxylate transaminase activity [GO:0008453]; pyridoxal phosphate binding [GO:0030170]

IPR005814;IPR015424;IPR015421;IPR015422;

3.90.1150.10;3.40.640.10;

A0A5F5XHI8

MAASCVLLHTGQKMPLIGLGTWKSDPGQVKAAVKYALSVGYRHIDCAAIYGNETEIGEALKENVGPGKVVPREEVFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNVDGTIRYDSTHYKETWKALEALVDKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLSQKELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVLALAEKYGRSPAQVLLRWQVQRKVISIPKSITPSRILQNIQVFDFTFSPEEMKQLDTLNKNWRYIVPMITVSIYHVLELENKCKFCSRSLAQNWPQPPWSEERQDVVGRIAFPAHSGLFYFY

Felis catus (Cat) (Felis silvestris catus)

1.1.1.19; 1.1.1.2; 1.1.1.20; 1.1.1.372; 1.1.1.54

CATALYTIC ACTIVITY: Reaction=3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH; Xref=Rhea:RHEA:58668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60777, ChEBI:CHEBI:142685; Evidence={ECO:0000256|ARBA:ARBA00023987}; CATALYTIC ACTIVITY: Reaction=L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH; Xref=Rhea:RHEA:14909, ChEBI:CHEBI:13115, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:142686; EC=1.1.1.19; Evidence={ECO:0000256|ARBA:ARBA00023919}; CATALYTIC ACTIVITY: Reaction=L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH; Xref=Rhea:RHEA:18925, ChEBI:CHEBI:15378, ChEBI:CHEBI:17587, ChEBI:CHEBI:18268, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.20; Evidence={ECO:0000256|ARBA:ARBA00023969}; CATALYTIC ACTIVITY: Reaction=a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH; Xref=Rhea:RHEA:15937, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.2; Evidence={ECO:0000256|ARBA:ARBA00023978}; CATALYTIC ACTIVITY: Reaction=allyl alcohol + NADP(+) = acrolein + H(+) + NADPH; Xref=Rhea:RHEA:12168, ChEBI:CHEBI:15368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16605, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.54; Evidence={ECO:0000256|ARBA:ARBA00023997}; CATALYTIC ACTIVITY: Reaction=glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH; Xref=Rhea:RHEA:23592, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.372; Evidence={ECO:0000256|ARBA:ARBA00023947}; CATALYTIC ACTIVITY: Reaction=glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH; Xref=Rhea:RHEA:38111, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27975, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.372; Evidence={ECO:0000256|ARBA:ARBA00023958}; CATALYTIC ACTIVITY: Reaction=hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH; Xref=Rhea:RHEA:27986, ChEBI:CHEBI:15378, ChEBI:CHEBI:17158, ChEBI:CHEBI:27957, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000256|ARBA:ARBA00024000};

Cell membrane;Cytoplasm;Membrane;NADP;Reference proteome

aldehyde catabolic process [GO:0046185]; cellular detoxification of aldehyde [GO:0110095]; D-glucuronate catabolic process [GO:0042840]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; L-ascorbic acid biosynthetic process [GO:0019853]

apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; synapse [GO:0045202]

alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; allyl-alcohol dehydrogenase activity [GO:0047655]; glucuronolactone reductase activity [GO:0047941]; L-glucuronate reductase activity [GO:0047939]; S-nitrosoglutathione reductase activity [GO:0080007]

SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004370}.

IPR020471;IPR044481;IPR018170;IPR023210;IPR036812;

3.20.20.100;

A0A5F5XIU7

MSGHRSTRKRCGDSHPESPMGFGHMSTPGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTVLLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIFDVTESQIIIIICQLLTGTLGPWFWNFTIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. {ECO:0000256|ARBA:ARBA00037663}.

2.7.8.1; 2.7.8.2; 2.7.8.22

CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54336, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:83717, ChEBI:CHEBI:84417; Evidence={ECO:0000256|ARBA:ARBA00035878}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54337; Evidence={ECO:0000256|ARBA:ARBA00035878}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54340, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:84417, ChEBI:CHEBI:138145; Evidence={ECO:0000256|ARBA:ARBA00036341}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54341; Evidence={ECO:0000256|ARBA:ARBA00036341}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54240, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74669; Evidence={ECO:0000256|ARBA:ARBA00036096}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54241; Evidence={ECO:0000256|ARBA:ARBA00036096}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54248, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:74986; Evidence={ECO:0000256|ARBA:ARBA00036523}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54249; Evidence={ECO:0000256|ARBA:ARBA00036523}; CATALYTIC ACTIVITY: Reaction=1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54236, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:78226; Evidence={ECO:0000256|ARBA:ARBA00036329}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54237; Evidence={ECO:0000256|ARBA:ARBA00036329}; CATALYTIC ACTIVITY: Reaction=1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54232, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:76979, ChEBI:CHEBI:78228; Evidence={ECO:0000256|ARBA:ARBA00036651}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54233; Evidence={ECO:0000256|ARBA:ARBA00036651}; CATALYTIC ACTIVITY: Reaction=1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:36227, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77286, ChEBI:CHEBI:77296; EC=2.7.8.22; Evidence={ECO:0000256|ARBA:ARBA00036576}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36228; Evidence={ECO:0000256|ARBA:ARBA00036576}; CATALYTIC ACTIVITY: Reaction=1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:36179, ChEBI:CHEBI:15378, ChEBI:CHEBI:36702, ChEBI:CHEBI:52595, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence={ECO:0000256|ARBA:ARBA00035779}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36180; Evidence={ECO:0000256|ARBA:ARBA00035779}; CATALYTIC ACTIVITY: Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54352, ChEBI:CHEBI:15378, ChEBI:CHEBI:55430, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77184; Evidence={ECO:0000256|ARBA:ARBA00036748}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54353; Evidence={ECO:0000256|ARBA:ARBA00036748}; CATALYTIC ACTIVITY: Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54348, ChEBI:CHEBI:15378, ChEBI:CHEBI:44811, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:75936; Evidence={ECO:0000256|ARBA:ARBA00036059}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54349; Evidence={ECO:0000256|ARBA:ARBA00036059}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54332, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74963, ChEBI:CHEBI:82949; Evidence={ECO:0000256|ARBA:ARBA00036100}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54333; Evidence={ECO:0000256|ARBA:ARBA00036100}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54244, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:73001, ChEBI:CHEBI:75466; Evidence={ECO:0000256|ARBA:ARBA00036890}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54245; Evidence={ECO:0000256|ARBA:ARBA00036890}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54252, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:73007, ChEBI:CHEBI:75466; Evidence={ECO:0000256|ARBA:ARBA00035972}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54253; Evidence={ECO:0000256|ARBA:ARBA00035972}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:32939, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence={ECO:0000256|ARBA:ARBA00035868}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32940; Evidence={ECO:0000256|ARBA:ARBA00035868}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:32943, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:64612; EC=2.7.8.1; Evidence={ECO:0000256|ARBA:ARBA00036031}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32944; Evidence={ECO:0000256|ARBA:ARBA00036031};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.; PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. {ECO:0000256|ARBA:ARBA00037890}.; PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. {ECO:0000256|ARBA:ARBA00037891}.

Endoplasmic reticulum;Glycoprotein;Lipid biosynthesis;Lipid metabolism;Manganese;Membrane;Nucleus;Phospholipid biosynthesis;Phospholipid metabolism;Reference proteome;Transferase;Transmembrane;Transmembrane helix

phosphatidylethanolamine biosynthetic process [GO:0006646]

endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]

diacylglycerol cholinephosphotransferase activity [GO:0004142]; ethanolaminephosphotransferase activity [GO:0004307]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004232}.

IPR000462;IPR043130;IPR048254;IPR014472;

1.20.120.1760;

A0A5F5XJ47

MSGGASEKQSSTPSSLFLSPPAPSPKNGSSSDSSVGEKLGSAGPDAGTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPAVSTAAPQSTPPEPHREETLTATAAAQVAQLPPAAAAPGEPAGAGAVAATAPSSTGRDRQVSQPNHVGSKEEPPSARSGSGGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKRKQEEINQKHQVEQQSSTSQAGVKQTPSASTGMPPASTTSASVSTQVEPEEPEADQHQQLQYQQTSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTIPGHTASVVQAQSQPHGVYPSSSMPRRGRSMSVCVPHLSAVPSLSRISPSAPSTPPPVLSASLSPSLLRIAPEETFAEKLSKALESVLPMHSASQRKHRRSSLPSLFVSTPQSMAHPCGGTPTYPESQIFFPTIHERPVSFSPPPTCPPKVAISQRRKSTSFLEAQTRHFQPLLRTVGQNLLPPGGSPTNWTPEAVVMLGTTASRITGEPCEIQVHPMFEPTQVHGDYRPGLVLPEEAHYFIPQEPVYLAYQAQVTEQYEGIPYNSPVLSSPMKQIPEQKPVPGGPTSSSVFEFPSGQAFLVGHLQNLRLDSGLSPGSPLSSISAPISTDATRLKFHPVFVPHSAPAVLTHNNESRSNCVFEFHVHTPSSSSGEGGGVLPQRVYRNRQVAVDLNQEEPPPQSVGLHGRLQPVTEEQRNYHAPELTVSVVEPIGQNWPIGSPEYSSDSSQITSSDPSDFQSPPPTGGAAAPFGSDVSLPFIRLPQTVLQESPLFFCFPQGATSQQVLSASFSSGGSALHPQAQGQSQGQPSSSSLTGVPSSLPIQHSQQQGVQQTAPPQQTVQYSLPQTSTSSEATTAQPVSQSQTPQVLPQVSSGKQLPVSQPVPAIQGEPQIPVATQPSVVPVHSGAHFLPLGQPLSTSLHPQYPVSQIPISTPHVSAAQTGFSSLPVTMAAGVNQPLLTLASSATAAAIPGGPTAVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVPLPSGDVLYQGFPPRLPPQYPGDSNIAPTSSVASICIPSTVLSPPMPTEALATPGYFPTVVQPFVESNLLVPVGSIGGQVQVSQPAVSLAQQAPTTSSQQAALESTQGVSQVAPPEPLPVAQSQPTTLVSSIDSAHSDVASGMSDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKSSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFAGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKLFTGEISDTVAASTSHGAGMNLSHSASSLSLQQAFSELRHAQMTEGPNTAPPNFSHTGPTFPVVPPSMSSIAAVPTTAAATPSISAPATSSPLNDMSTSVIQSEIPVPTEKGIGGVATCTGVIPSSGLPVPPISESPVFSTVVSSVTIPTVVSISTTSQPVQASTSGSVVSSIGTLPSIPVSTLASAAGSAAVSGAKPPPVVSQQATGSTSGVATLTSIAATTPFPSIASQLPLQLSSSTSAPTLAETVVVSAHSLDKTSHSSTTGLALSLSASSSSSPGAGLSSSVSQPDGVHPLVTPSAIASTPVLPQAAGPTSTPLLPQVPSIPPLVQPVASVPAVQQTLIHSQPQPALLPNQPHTHCPEIDADSQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVVETTVAPGIPTTAVAPSKLMTSTTSTCLPPTSLPLGTTGLSVIPVVTPGQVSTPVSYVSAPVSTTSGVKAGTAPSKPPLTKAPVLPVGTELPAGTPPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPETVVGTCTVGPVSMVAPAAVTEAGTPPQKDVSQITEGPVLGTSSGTGVFKMGRFQVSVAMDDVQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLVKTEPNGIRSISSDMPDSAHKTPALGVKSETGQPTKVGRFQVTTTTNKVGRFSVSRTEDKIAEAKKEGPMASPPFMDLEQAVLPAVIPKKEKPELSEPSHLNGPSSDLEAAFLSRDVDDGSGSPHSPHQLSSKSLPIQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLREKHLKEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLAGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSATSVLHPQQTLHPPGNIPETGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGCAKFNCASEQVTFKPGGRRTRFLSTPCLALWKMVKKVCPCNQLCRTSSTNTVGGTVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPAPPFGTQWSGTGGPTPQPLGQFQPVGTASLQNFNISNLQKSISNPPGSNLRTT

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Transferase

cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; heart development [GO:0007507]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; lymphocyte migration into lymph node [GO:0097022]; monoatomic ion homeostasis [GO:0050801]; negative regulation of autophagy [GO:0010507]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of sodium ion transport [GO:0010766]; non-membrane-bounded organelle assembly [GO:0140694]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of termination of RNA polymerase II transcription [GO:1904595]; potassium ion homeostasis [GO:0055075]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; regulation of mRNA export from nucleus [GO:0010793]; regulation of sodium ion transmembrane transport [GO:1902305]; sodium ion transmembrane transport [GO:0035725]; T cell receptor signaling pathway [GO:0050852]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]

ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; phosphatase binding [GO:0019902]; potassium channel inhibitor activity [GO:0019870]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR024678;IPR000719;IPR008271;

1.10.510.10;

A0A5F5XJA0

MESPLCVSIFLVLCVFIQSSAHGQSLGLGPFGRRPRAAETKEASQETEIRFLLFEETDKGCQIRLNHPDTLQQCGFNSSLPLVMIIHGWSVDGFLEDWIWQMVAALKSGMAQPVNVGLADWLTLAYHHYTMAVHNTRHVGREVAALIRWLEESVQFSRSNVHLIGYSLGAHVAGFAGSYIGGKHKIGRITGLDAAGPLFEGSSPSDRLSPDDANFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGYFQPGCHFLQLYKHISKHGLNAITQTIKCSHERSVHLFIDSLLHASMQSTAYQCSDMGTFSQGLCLSCKKGHCNTLGYHVRQEWQGKKSKKLFLATRAQSPFKVYHYQFKIQFINQLEKPVEPTFTMTLLGTKEENQKITITLDQEITSNKTYSFLITLDLDIGELVMIKFKWENGAVWTNVWNTVQTIIPWSRRPLYSGLVAKTIRVKAGETQQRMTFCSENTDGLRLQPTQEKTFVRCNRNSKKLKGNIR

Felis catus (Cat) (Felis silvestris catus)

3.1.1.3; 3.1.1.32; 3.1.1.5

CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38391, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75824; Evidence={ECO:0000256|ARBA:ARBA00001610}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38392; Evidence={ECO:0000256|ARBA:ARBA00001610}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence={ECO:0000256|ARBA:ARBA00000652}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence={ECO:0000256|ARBA:ARBA00000652}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083; Evidence={ECO:0000256|ARBA:ARBA00001885}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700; Evidence={ECO:0000256|ARBA:ARBA00001885}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52333, ChEBI:CHEBI:73990; Evidence={ECO:0000256|ARBA:ARBA00001101}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38512; Evidence={ECO:0000256|ARBA:ARBA00001101}; CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:41384, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64563, ChEBI:CHEBI:72999; Evidence={ECO:0000256|ARBA:ARBA00000879}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41385; Evidence={ECO:0000256|ARBA:ARBA00000879}; CATALYTIC ACTIVITY: Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+); Xref=Rhea:RHEA:38651, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75735, ChEBI:CHEBI:75938; Evidence={ECO:0000256|ARBA:ARBA00000265}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38652; Evidence={ECO:0000256|ARBA:ARBA00000265}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine; Xref=Rhea:RHEA:40499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64765, ChEBI:CHEBI:74617; Evidence={ECO:0000256|ARBA:ARBA00000834}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40500; Evidence={ECO:0000256|ARBA:ARBA00000834}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000256|ARBA:ARBA00000597}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence={ECO:0000256|ARBA:ARBA00000597}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32; Evidence={ECO:0000256|ARBA:ARBA00000111}; CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5; Evidence={ECO:0000256|ARBA:ARBA00000960}; CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000256|ARBA:ARBA00001024};

Calcium;HDL;Heparin-binding;Lipid degradation;Lipid metabolism;Metal-binding;Reference proteome;Secreted;Signal

cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; low-density lipoprotein particle remodeling [GO:0034374]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]

extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]

1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; apolipoprotein binding [GO:0034185]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lysophospholipase activity [GO:0004622]; metal ion binding [GO:0046872]; phosphatidyl phospholipase B activity [GO:0102545]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]

SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.

IPR029058;IPR013818;IPR002333;IPR016272;IPR033906;IPR001024;IPR036392;IPR000734;

3.40.50.1820;2.60.60.20;

A0A5F5XJL4

MDSKIQRVRDAFASGRSRPLRFRLQQLEALRRMVQEREKDILEAIAADLCKSELNAYSQEVITVLGELDLVLENLPEWVAAKPAKKNLFTMLDEAYIHSEPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELCEKTATVLAKLLPQYLDQDLYVVINGGVEETTELLKQRFDHILYTGSTAVGKIVMEAAAKHLTPVTLELGGKSPCYVDRDCDLDVACRRIAWGKYMNCGQTCIAPDYVLCEPSLQNQIVQKIKETVKEFYGENIKESPDYERIINLRHFKRIQGLLEGQKIAFGGETDEATRYIAPTILTDVDPETKVMQEEIFGPILPIVPVRNADEAIKFINNREKPLAFYVFSHNEKLIRRMIDSTSSGGVTANDVIMHFTLSSLPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKTLKREGANKLRYPPNSQSKVDWAKFFLLKRFNKGKLGLLLLAFLGIVAAVLVKFRLCRPVSSDESHRTQDPALSVKSEVGTACFLSL

Felis catus (Cat) (Felis silvestris catus)

CATALYTIC ACTIVITY: Reaction=(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:36135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17585, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:72745; Evidence={ECO:0000256|ARBA:ARBA00035777}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH; Xref=Rhea:RHEA:24216, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15894, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:83276; EC=1.2.1.94; Evidence={ECO:0000256|ARBA:ARBA00036228}; CATALYTIC ACTIVITY: Reaction=2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+); Xref=Rhea:RHEA:33739, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17600, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00035953}; CATALYTIC ACTIVITY: Reaction=2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:44016, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:49189, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77268; Evidence={ECO:0000256|ARBA:ARBA00035974}; CATALYTIC ACTIVITY: Reaction=22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH; Xref=Rhea:RHEA:39015, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:76298, ChEBI:CHEBI:76299; Evidence={ECO:0000256|ARBA:ARBA00036932}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate; Xref=Rhea:RHEA:44020, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17034, ChEBI:CHEBI:25629, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00035984}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate; Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00000589}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate; Xref=Rhea:RHEA:44172, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:84067; Evidence={ECO:0000256|ARBA:ARBA00035786}; CATALYTIC ACTIVITY: Reaction=H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH; Xref=Rhea:RHEA:44108, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32362, ChEBI:CHEBI:34787, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036881}; CATALYTIC ACTIVITY: Reaction=a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH; Xref=Rhea:RHEA:49832, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:35746, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036717}; CATALYTIC ACTIVITY: Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00024149}; CATALYTIC ACTIVITY: Reaction=decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:44104, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:31457, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036332}; CATALYTIC ACTIVITY: Reaction=dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+); Xref=Rhea:RHEA:44168, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:27836, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036265};

Endoplasmic reticulum;Fatty acid metabolism;Lipid metabolism;Membrane;Microsome;Oxidoreductase;Reference proteome;Transmembrane;Transmembrane helix

cellular aldehyde metabolic process [GO:0006081]; central nervous system development [GO:0007417]; epidermis development [GO:0008544]; fatty acid metabolic process [GO:0006631]; hexadecanal metabolic process [GO:0046458]; peripheral nervous system development [GO:0007422]; phytol metabolic process [GO:0033306]

cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]

3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; long-chain-alcohol oxidase activity [GO:0046577]; long-chain-aldehyde dehydrogenase activity [GO:0050061]; medium-chain-aldehyde dehydrogenase activity [GO:0052814]; protein homodimerization activity [GO:0042803]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004131}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004131}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004131}.

IPR016161;IPR016163;IPR016160;IPR029510;IPR016162;IPR015590;IPR012394;

A0A5F5XJP2

MNEPAEGRGLVGARASTGVAGAQPPRTQQRHRPFRPRRGRLGSHGGGAAAGADSARPLPPAPPRAAAAGPAAVSSLSDQDGQDAAETRCMLSRCSRRLLHVLGLSFPLLTCRPLFLWPHRLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKDGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNNTMDGKAEVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKSVDEVTSFPVLGTAKGRS

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000256|HAMAP-Rule:MF_03172}.

2.7.4.14; 2.7.4.6

CATALYTIC ACTIVITY: Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600, ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.4.14; Evidence={ECO:0000256|HAMAP-Rule:MF_03172}; CATALYTIC ACTIVITY: Reaction=ATP + UMP = ADP + UDP; Xref=Rhea:RHEA:24400, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.14; Evidence={ECO:0000256|ARBA:ARBA00001331, ECO:0000256|HAMAP-Rule:MF_03172}; CATALYTIC ACTIVITY: Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094, ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593, ChEBI:CHEBI:456216; EC=2.7.4.14; Evidence={ECO:0000256|HAMAP-Rule:MF_03172}; CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|HAMAP-Rule:MF_03172}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|HAMAP-Rule:MF_03172};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-Rule:MF_03172}; Note=Binds 1 Mg(2+) ion per monomer. {ECO:0000256|HAMAP-Rule:MF_03172};

ATP-binding;Cytoplasm;Kinase;Nucleotide-binding;Nucleus;Pyrimidine biosynthesis;Reference proteome;Transferase

'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; phosphorylation [GO:0016310]; UDP biosynthetic process [GO:0006225]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; UMP kinase activity [GO:0033862]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_03172}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03172}. Note=Predominantly nuclear. {ECO:0000256|HAMAP-Rule:MF_03172}.

DOMAIN: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. {ECO:0000256|HAMAP-Rule:MF_03172}.

IPR000850;IPR033690;IPR027417;IPR006266;

3.40.50.300;

A0A5F5XKF2

MESKTLFLMALGIWLQSLTTTRGWVAADDRITGGRDFIDIESKFALRTPEDIAEDTCHLIPGVTESVANCHFNHTSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQQHYPVSAGYTKLVGKDVAKFINWMAEEFHYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESDTQTNQVFEISLYGTVAESENIPFTLPEISANKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFTIEKIRVKAGETQKKNWANLQKEEQNTNSMKNGVTFTSDAQCFGCFKDKFPEY

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. {ECO:0000256|RuleBase:RU362020}.

3.1.1.34

CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.34; Evidence={ECO:0000256|ARBA:ARBA00000137, ECO:0000256|RuleBase:RU362020};

Calcium;Cell membrane;Chylomicron;Disulfide bond;Extracellular matrix;Glycoprotein;Heparin-binding;Hydrolase;Lipid degradation;Lipid metabolism;Membrane;Metal-binding;Nitration;Reference proteome;Secreted;Signal;VLDL

cellular response to fatty acid [GO:0071398]; cellular response to nutrient [GO:0031670]; cholesterol homeostasis [GO:0042632]; chylomicron remodeling [GO:0034371]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; low-density lipoprotein particle mediated signaling [GO:0055096]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of sequestering of triglyceride [GO:0010890]; positive regulation of tumor necrosis factor production [GO:0032760]; response to bacterium [GO:0009617]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]

catalytic complex [GO:1902494]; cell surface [GO:0009986]; chylomicron [GO:0042627]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]

apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lipoprotein particle binding [GO:0071813]; phospholipase A1 activity [GO:0008970]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362020}; Peripheral membrane protein {ECO:0000256|RuleBase:RU362020}; Extracellular side {ECO:0000256|RuleBase:RU362020}. Secreted {ECO:0000256|RuleBase:RU362020}. Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU362020}. Note=Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells. Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles. {ECO:0000256|RuleBase:RU362020}.

PTM: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. {ECO:0000256|RuleBase:RU362020}.

IPR029058;IPR013818;IPR016272;IPR033906;IPR002330;IPR001024;IPR036392;IPR000734;

3.40.50.1820;2.60.60.20;

A0A5F5XKW9

ESRSSHGNPVTKPTISPSFLFQVSCAGWFPSLSHPARDARAPPLAPPPARDVTTRAAHRAPCQRQPLFSRSRWLCQGWVGPAPLSKSRPLLKAGRGGQSAALSTLRSSGVGHHEQTEGATGDAERGNHGHAHRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKHEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHRVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. {ECO:0000256|RuleBase:RU366014}.

2.7.7.7

CATALYTIC ACTIVITY: Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695, ChEBI:CHEBI:167181; EC=4.2.99.18; Evidence={ECO:0000256|ARBA:ARBA00024490}; CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|RuleBase:RU366014}; CATALYTIC ACTIVITY: Reaction=a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:76255, Rhea:RHEA-COMP:13180, Rhea:RHEA-COMP:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:195194, ChEBI:CHEBI:195195; Evidence={ECO:0000256|ARBA:ARBA00035582};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

DNA damage;DNA repair;DNA replication;DNA synthesis;DNA-binding;DNA-directed DNA polymerase;Lyase;Methylation;Nucleotidyltransferase;Nucleus;Reference proteome;Sodium;Transferase;Ubl conjugation

base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA replication [GO:0006260]; double-strand break repair via nonhomologous end joining [GO:0006303]; homeostasis of number of cells [GO:0048872]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lymph node development [GO:0048535]; neuron apoptotic process [GO:0051402]; salivary gland morphogenesis [GO:0007435]; somatic hypermutation of immunoglobulin genes [GO:0016446]; spleen development [GO:0048536]

cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle microtubule [GO:0005876]

5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU366014}.

IPR002054;IPR019843;IPR010996;IPR028207;IPR018944;IPR027421;IPR037160;IPR022312;IPR002008;IPR003583;IPR043519;IPR029398;

1.10.150.20;3.30.460.10;1.10.150.110;3.30.210.10;

A0A5F5XNE0

MLTLPQTPPISSGDPLLSEPQFSHLYKRSQGKQAVGGGGYNYLLGTAFEDTEAKSRRGPWGDRHLEAGWASTYQQGASQTGSCGASEDQGLILLKVWASSSERKSWTLAGPAPSEEAGTRARFPLSDAVEEGAWTAEVVGQQDSALSLQLSTPPNAPIGLYRLSLEASTGYQGSSFVLGHFILLFNPWCPGDAVYLDSDEERHEYILTQHGFIYQGLATFIKNIPWNFGQFEDGILDICLTLLDMNPKFLRDAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGISPMFWIGSVDILRRWKSSGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMSRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQDDGSMHKSINHSLVVGLKISTKSVGRDERQDITHTYKYPEGSPEEREAFKRANHLNKLTEKEDTGMAMRIRVSQSMSMGSDFDVFAYITNNTSEEHTCRLLLCARTVSYNGILGPECGTKDLLNLSLAPFSEKSIPLRILYEKYCDCLTESNLIKVRGLLTEPAVNSYLLAERDIYLENPEIKIRILGEPKQKRKLVAEVSLRNPLTTPLSDCIFTVEGAGLTEEQKVVEIPDPVEAGEDAKVRVDLLPLHVGRHKLVVNFESDKLKAVKGFRNVIVGPA

Felis catus (Cat) (Felis silvestris catus)

2.3.2.13; 3.5.1.44

CATALYTIC ACTIVITY: Reaction=(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:66560, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17054, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:72587, ChEBI:CHEBI:167178; Evidence={ECO:0000256|ARBA:ARBA00036051}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66561; Evidence={ECO:0000256|ARBA:ARBA00036051}; CATALYTIC ACTIVITY: Reaction=H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:16441, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:10208, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29973, ChEBI:CHEBI:30011; EC=3.5.1.44; Evidence={ECO:0000256|ARBA:ARBA00036025}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16442; Evidence={ECO:0000256|ARBA:ARBA00036025}; CATALYTIC ACTIVITY: Reaction=L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:54816, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:14005, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:30011, ChEBI:CHEBI:138370; EC=2.3.2.13; Evidence={ECO:0000256|ARBA:ARBA00036876}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54817; Evidence={ECO:0000256|ARBA:ARBA00036876}; CATALYTIC ACTIVITY: Reaction=L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:66552, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17052, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:167174, ChEBI:CHEBI:350546; Evidence={ECO:0000256|ARBA:ARBA00036377}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66553; Evidence={ECO:0000256|ARBA:ARBA00036377}; CATALYTIC ACTIVITY: Reaction=dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:66556, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17053, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:59905, ChEBI:CHEBI:167175; Evidence={ECO:0000256|ARBA:ARBA00036119}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66557; Evidence={ECO:0000256|ARBA:ARBA00036119}; CATALYTIC ACTIVITY: Reaction=histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+); Xref=Rhea:RHEA:66564, Rhea:RHEA-COMP:10207, Rhea:RHEA-COMP:17056, ChEBI:CHEBI:28938, ChEBI:CHEBI:30011, ChEBI:CHEBI:58432, ChEBI:CHEBI:167179; Evidence={ECO:0000256|ARBA:ARBA00036107}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66565; Evidence={ECO:0000256|ARBA:ARBA00036107};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR000459-2}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};

Acyltransferase;Calcium;Cell membrane;Chromosome;Extracellular matrix;GTP-binding;Hydrolase;Membrane;Metal-binding;Mitochondrion;Nucleotide-binding;Nucleus;Protease;Reference proteome;Secreted;Transferase

apoptotic cell clearance [GO:0043277]; branching involved in salivary gland morphogenesis [GO:0060445]; cellular response to cocaine [GO:0071314]; cellular response to dopamine [GO:1903351]; cellular response to serotonin [GO:1904015]; dopamine secretion [GO:0014046]; gene expression [GO:0010467]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of neurogenesis [GO:0050769]; proteolysis [GO:0006508]; regulation of apoptotic cell clearance [GO:2000425]; salivary gland cavitation [GO:0060662]

collagen-containing extracellular matrix [GO:0062023]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]

calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; histone dopaminyltransferase activity [GO:0120297]; histone serotonyltransferase activity [GO:0120295]; peptidase activity [GO:0008233]; peptide histaminyltransferase activity [GO:0120299]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]; protein-glutamine glutaminase activity [GO:0050568]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Chromosome {ECO:0000256|ARBA:ARBA00004286}. Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Membrane {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.

IPR013783;IPR014756;IPR038765;IPR002931;IPR036985;IPR023608;IPR013808;IPR008958;IPR036238;IPR001102;

2.60.40.10;3.90.260.10;

A0A5F5XQN2

MTMYLWLKLLAFGFAFLDTGVFVTGEDNTLSSPGLNSTEKPSVLAPSDPLPARTTAFSLTSISEREYNSSETTPTLSPDNPSTEDFLNSLDNANTLNVTGVTQPPTFPTHADSQAPSAGSDTQTPSSTATPPALTPAPGKNDTSGFPGETIPPSTFPADTAFTPVATLSPALSSSAALPSLISSITTKDNSSDQSLTSTSPATSIMTASATVPTTPKQSCDEKYKVISVKYRYDYGNNSFIAKLNVSDDVMCENAICKMNEILNLPACENKNVTISHTSCDPPNKIIELDVPPDPESFYLKTCTEPTKANISICLRLEKKENFTCDEEKITHVLSCANFSSSNKTETYLEPLSPKQNYSCNLKVSYGANEFLNKNETFETDVGSPKAPPNITCKPTSSTEGRITWESPEDYFDNYVLCLPHASEKFILLGKEETEHNLQNLKPYTKYSVSLKASTMGKVQRDGPAVTCEFETLADKPTKVRNLLASRISDNSILVKCDPPLDFKGPSNGSYHLEIKTGDAFVKNESQIICHFSVLYLQYSTKYEFKVYYNNGHHNGTPESVFHSTSYNSKALIAFLVFLIIVTFLALLFVLYKIYDLRNRRSSNIDEQQELVERDDEKQLMSVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFSIKDARKTFNQNKNRYVDILPYDYNRVELSDINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRTFGDVVVKITEHKRCPDYIIQKLNITNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVSLSELHPYLLNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEQNKSKNRNSNIIPYDFNRVPLKHELEMSKESEHDSDESSDDDSDSEETSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTGLKNGDQEVCAQYWGEGKQTYGDIQVDMKDTNQSSAYTLRVFELRHSKRKDFRTVYQYQYNNWNVDELPPEPKELISMIQILKEKLPKKNSTEGTKHHKNVPLLIHCRDGSQQTGLFCALLNLLESAETEEVIDVFQVVKSLRRARPGMVPTFEQYQFLYDIVASAYPAQNGQIKKSNNQEDKIEFDNELDKAKQDANCVSSPDALDKANEGNKEDEGAKVTSSPEEPEHSANGPASPGLTQSA

Felis catus (Cat) (Felis silvestris catus)

3.1.3.48

CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000256|ARBA:ARBA00001490};

Glycoprotein;Hydrolase;Membrane;Protein phosphatase;Reference proteome;Signal;Transmembrane;Transmembrane helix

alpha-beta T cell proliferation [GO:0046633]; B cell differentiation [GO:0030183]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle phase transition [GO:0044770]; cellular response to extracellular stimulus [GO:0031668]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; extrinsic apoptotic signaling pathway [GO:0097191]; gamma-delta T cell differentiation [GO:0042492]; hematopoietic progenitor cell differentiation [GO:0002244]; heterotypic cell-cell adhesion [GO:0034113]; leukocyte cell-cell adhesion [GO:0007159]; MAPK cascade [GO:0000165]; natural killer cell differentiation [GO:0001779]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative thymic T cell selection [GO:0045060]; plasma membrane raft distribution [GO:0044855]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phagocytosis [GO:0050766]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of tumor necrosis factor production [GO:0032760]; positive thymic T cell selection [GO:0045059]; regulation of cell cycle [GO:0051726]; regulation of interleukin-8 production [GO:0032677]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; release of sequestered calcium ion into cytosol [GO:0051209]; stem cell development [GO:0048864]; synaptic membrane adhesion [GO:0099560]; T cell receptor signaling pathway [GO:0050852]

bleb [GO:0032059]; external side of plasma membrane [GO:0009897]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]

ankyrin binding [GO:0030506]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; signaling receptor binding [GO:0005102]; spectrin binding [GO:0030507]

IPR003961;IPR036116;IPR013783;IPR029021;IPR000242;IPR024739;IPR016335;IPR016130;IPR003595;IPR000387;

2.60.40.10;3.90.190.10;

A0A5F5XQU1

MSRESDPGVPRNPCLCLGGALNARLSPNVSHSAGRSRLLRFPLLLLLLLLQPPQVLPADSRAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPELWTWLRNSLRPSPAFLHFLLTHGRWFWEFVNATFIRDMLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPQDCPTPMGTKGKKQLPDAQILGHRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLHGEMYPPSVEEAPVLMHYPRNIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNQLYHWHPLMPDSFKVGSREYSYEQFLFNTSMLVDYGVEALVDAFSRQSAGRIGGGRNMDHHVLHVAVDVIKESRELRLQPFNEYRKRFGLRPYTSFQELTGEKEMAAELEELYGDIDALEFFPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFHVPDPHQDDGPGVERPSTEL

Felis catus (Cat) (Felis silvestris catus)

1.14.99.1

CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2; Xref=Rhea:RHEA:42596, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:82629; Evidence={ECO:0000256|ARBA:ARBA00000144}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42597; Evidence={ECO:0000256|ARBA:ARBA00000144}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:23728, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:32395, ChEBI:CHEBI:57405; EC=1.14.99.1; Evidence={ECO:0000256|ARBA:ARBA00001779}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23729; Evidence={ECO:0000256|ARBA:ARBA00001779}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O; Xref=Rhea:RHEA:75455, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:136655; Evidence={ECO:0000256|ARBA:ARBA00036409}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75456; Evidence={ECO:0000256|ARBA:ARBA00036409}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O; Xref=Rhea:RHEA:75451, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:90850; Evidence={ECO:0000256|ARBA:ARBA00036358}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75452; Evidence={ECO:0000256|ARBA:ARBA00036358}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O; Xref=Rhea:RHEA:75447, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:77895; Evidence={ECO:0000256|ARBA:ARBA00036313}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75448; Evidence={ECO:0000256|ARBA:ARBA00036313}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O; Xref=Rhea:RHEA:75459, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:30245, ChEBI:CHEBI:77852; Evidence={ECO:0000256|ARBA:ARBA00035976}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:75460; Evidence={ECO:0000256|ARBA:ARBA00035976}; CATALYTIC ACTIVITY: Reaction=AH2 + prostaglandin G2 = A + H2O + prostaglandin H2; Xref=Rhea:RHEA:42600, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:57405, ChEBI:CHEBI:82629; Evidence={ECO:0000256|ARBA:ARBA00000489}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42601; Evidence={ECO:0000256|ARBA:ARBA00000489};

COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000256|ARBA:ARBA00001970};

PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000256|ARBA:ARBA00004702}.

Dioxygenase;EGF-like domain;Endoplasmic reticulum;Fatty acid biosynthesis;Fatty acid metabolism;Heme;Iron;Lipid biosynthesis;Lipid metabolism;Metal-binding;Microsome;Oxidoreductase;Peroxidase;Prostaglandin biosynthesis;Prostaglandin metabolism;Reference proteome

cyclooxygenase pathway [GO:0019371]; regulation of blood pressure [GO:0008217]; regulation of cell population proliferation [GO:0042127]; response to oxidative stress [GO:0006979]

cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; photoreceptor outer segment [GO:0001750]

heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]

IPR000742;IPR019791;IPR010255;IPR037120;

1.10.640.10;2.10.25.10;

A0A5F5XT25

MPLPSSRLATWRPAEPGDASAGGQPLLRGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSSLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPAIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI

Felis catus (Cat) (Felis silvestris catus)

2.7.11.30

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023945}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00023948, ECO:0000256|RuleBase:RU361271};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU361271}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|RuleBase:RU361271};

ATP-binding;Disulfide bond;Kinase;Magnesium;Manganese;Membrane;Metal-binding;Nucleotide-binding;Receptor;Reference proteome;Serine/threonine-protein kinase;Signal;Transferase;Transmembrane;Transmembrane helix

activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic foregut morphogenesis [GO:0048617]; gastrulation with mouth forming second [GO:0001702]; heart development [GO:0007507]; insulin secretion [GO:0030073]; kidney development [GO:0001822]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; mesoderm development [GO:0007498]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis of dentin-containing tooth [GO:0042475]; organ growth [GO:0035265]; pancreas development [GO:0031016]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; post-embryonic development [GO:0009791]; response to glucose [GO:0009749]; retina vasculature development in camera-type eye [GO:0061298]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; venous blood vessel development [GO:0060841]

activin receptor complex [GO:0048179]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]

activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; protein serine/threonine/tyrosine kinase activity [GO:0004712]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.

IPR000472;IPR011009;IPR000719;IPR008271;IPR045860;IPR000333;

2.10.60.10;1.10.510.10;

A0A5F5XUM6

MRWGLVGYEVLQSTMAEQLLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKSMHRYTLEMFRTCQFCPQFREIIHKALIDRTIQASLESQKKLNWCREVRKLVALKTNGDGNCLMHAASQYMWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWTDEWDSLVKMASTDTPMARGGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIILGYDSQHFVPLVTLKDSGPEIRAVPLVNRERGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSEQERREAHAQNPLEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQNNHTKSSKLHSKPGPEGLPGVAAGASRGEAYEPGGWSPEEPTGGPHSAPPTAPSLFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHQARQLNGGHTSDSMRHLDPGKCRACLQDVTRTFNGICSTCFKRTTAEPSSGLSSSVPPSCHQRSKSDPSQLIQSLSPHSCRRAGTEAPSGCLSQAPRTPGDRTGTSKCRKAGCMYFGTPENKGFCTLCFIEYRENKHFVAASTKASPTAPRFQNAVPCLGRECGTLGSTVFEGYCQKCFIEAQTQRFHEAKRTEEHLRSSQRRDVPRTTPSASRPKCARASCKNILACRSEELCMECQHLSQRAGPTPHRGEPAPEEPPKQRCRAPACDHFGNAKCNGYCNECFQFKQLYG

Felis catus (Cat) (Felis silvestris catus)

3.4.19.12

CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};

Cytoplasm;Hydrolase;Metal-binding;Nucleus;Phosphoprotein;Reference proteome;Zinc;Zinc-finger

B-1 B cell homeostasis [GO:0001922]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; cytoskeleton organization [GO:0007010]; establishment of protein localization to vacuole [GO:0072666]; negative regulation of B cell activation [GO:0050869]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of Wnt signaling pathway [GO:0030177]; protein K48-linked ubiquitination [GO:0070936]; regulation of germinal center formation [GO:0002634]; response to muramyl dipeptide [GO:0032495]; tolerance induction to lipopolysaccharide [GO:0072573]

cytoplasm [GO:0005737]; nucleus [GO:0005634]

cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein self-association [GO:0043621]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR003323;IPR002653;

1.20.5.4770;3.90.70.80;4.10.240.30;

A0A5F5XVG8

MTQTPAFDKPKVELHIHLDGAIKPETILYYGKKRGIALPADTTEELRDIIGMDKPTSLPGFLAKFDYYMPVIAGSREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWDQAEGDLTPDEVVAVVNQGLQEGERDFGVKVRSILCCMRHQPNWSLEVVELCKKYQHQTVVAIDLAGDETIQGSSLFPGHVQAYEAVDTLKTERVGHGYHTLDDEALYTRLRRENLHFEVSGRGARGPRRKARGRRGRASVAGLGSGHQSRQDGGHRTRQLGGQRGCAENGVRAGVTPWGVPAWGLGTVWPGGTRASYLPALPGLPLVQLPHRRLEVRHGAPGGSVRPRPWDPFGFVQQSEGWEGSAGAGCWPTRGLLIGNLSEALGSRCCRPHLTDEEPKPRVCYNVPRKPRSQIVDRGPLHSCGHRAMFRWP

Felis catus (Cat) (Felis silvestris catus)

3.5.4.4

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947};

Reference proteome

adenosine catabolic process [GO:0006154]; allantoin metabolic process [GO:0000255]; alpha-beta T cell differentiation [GO:0046632]; amide catabolic process [GO:0043605]; AMP catabolic process [GO:0006196]; AMP salvage [GO:0044209]; B cell proliferation [GO:0042100]; calcium-mediated signaling [GO:0019722]; dAMP catabolic process [GO:0046059]; dATP catabolic process [GO:0046061]; deoxyadenosine catabolic process [GO:0006157]; embryonic digestive tract development [GO:0048566]; germinal center B cell differentiation [GO:0002314]; germinal center formation [GO:0002467]; GMP salvage [GO:0032263]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; leukocyte migration [GO:0050900]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mature B cell apoptotic process [GO:0002901]; mucus secretion [GO:0070254]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of mucus secretion [GO:0070256]; negative regulation of penile erection [GO:0060407]; negative regulation of thymocyte apoptotic process [GO:0070244]; penile erection [GO:0043084]; Peyer's patch development [GO:0048541]; placenta development [GO:0001890]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of germinal center formation [GO:0002636]; positive regulation of heart rate [GO:0010460]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to purine-containing compound [GO:0014074]; smooth muscle contraction [GO:0006939]; T cell activation [GO:0042110]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; thymocyte apoptotic process [GO:0070242]; trophectodermal cell differentiation [GO:0001829]; xanthine biosynthetic process [GO:0046111]

cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; lysosome [GO:0005764]

2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; zinc ion binding [GO:0008270]

IPR001365;IPR006330;IPR032466;

3.20.20.140;

A0A5F5XWT4

MASPGLLLCLLSAAVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMERGGAHFVNAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGFDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSGLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIMYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPSDMDGKSILKLLDTERPVNRFHLKKKVRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDASGKLKLHRCKAPARPGGRALSNLVPKYYGQGGDACLCAGSDYKLSLAGRRKKFFKKKYKTGYARNRSIRSVAIEADGGVHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPGDFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLGLYQSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHKGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPLWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRYRFLLLSPGTAPRSWPVSGLTSVARVRLRPCPFSGLPGAWFAHQGEGTGSS

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. {ECO:0000256|PIRNR:PIRNR036665}.

3.1.6.-

CATALYTIC ACTIVITY: Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; EC=3.1.6.14; Evidence={ECO:0000256|ARBA:ARBA00034997}; CATALYTIC ACTIVITY: Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence={ECO:0000256|ARBA:ARBA00034984};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR036665-52}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR036665-52};

Calcium;Coiled coil;Endoplasmic reticulum;Golgi apparatus;Hydrolase;Metal-binding;Reference proteome;Signal

bone development [GO:0060348]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]

cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]

arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]

SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR036665}. Golgi apparatus, Golgi stack {ECO:0000256|ARBA:ARBA00004348, ECO:0000256|PIRNR:PIRNR036665}. Cell surface {ECO:0000256|PIRNR:PIRNR036665}.

PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000256|PIRSR:PIRSR036665-50}.

IPR017850;IPR014615;IPR024609;IPR024607;IPR000917;

3.40.720.10;

A0A5F5XWX0

MSRPPATGKMPGAPEAVSGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRENDSIQSRKNEIQKKLYTLEEHLSTEIQAKEELEQKCKSVNTRLEKVAKELEEEITLRKNVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESTKQIQQLESNNRDLQDKNCLLETAKLKLEKDFINLQSVLESERRDRTHGSEIINDLQGRISGLEEDLKNGKILLAKVEMEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKNLSEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLKQKDVLNEDIRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQKKQEFEDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMALDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPVHITQSRTMESLSFTYQRSSTSLNIATKPSSSHMLLDSDSDSEEESLPYLPISSEPDGTESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDRKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPRLLDLAFKDWDWSFDDVDGGDDDDDVFDF

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

ATP-binding;Biological rhythms;Cell membrane;Coiled coil;Cytoplasm;Cytoskeleton;Kinase;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc;Zinc-finger

actomyosin structure organization [GO:0031032]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; mitotic cytokinesis [GO:0000281]; modulation by host of viral process [GO:0044788]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein localization to lysosome [GO:0150033]; phosphorylation [GO:0016310]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; regulation of cell junction assembly [GO:1901888]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of keratinocyte differentiation [GO:0045616]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939]

centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]

ATP binding [GO:0005524]; metal ion binding [GO:0046872]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR000961;IPR046349;IPR011072;IPR011009;IPR002219;IPR011993;IPR001849;IPR000719;IPR017441;IPR029878;IPR037311;IPR015008;IPR008271;

1.20.5.340;3.30.60.20;2.30.29.30;1.20.5.730;1.10.510.10;

A0A5F5XXA8

MGRGLLRGLWPLHIVLWTRIASTIPPHVLKSVNNGMMVTDNNGIIKFPQLCKFCDVRSSTCDSQKSCLSNCSITSICERPHEVCLAVWRKNDENITLETLCHDPKVTYHGIALEDSASPKCIMKEKKVLGETFFMCSCSTDECNDYIIFSEDLQFMLSRESCGWHPVPVFKRNASTISPLESSLLKTIEYATNNPDLLLVIFQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWDTSKPRKLMEFSEHLAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRTLGSSLARGIAHLHSDHTLCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKEYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELQHLDRLSGRSCSEEKIPEDGSLNTTK

Felis catus (Cat) (Felis silvestris catus)

2.7.11.30

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

Apoptosis;ATP-binding;Cell membrane;Disulfide bond;Growth regulation;Kinase;Manganese;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Serine/threonine-protein kinase;Signal;Transferase;Transmembrane;Transmembrane helix

aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; brain development [GO:0007420]; branching involved in blood vessel morphogenesis [GO:0001569]; bronchus morphogenesis [GO:0060434]; cardiac left ventricle morphogenesis [GO:0003214]; cellular response to growth factor stimulus [GO:0071363]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic hemopoiesis [GO:0035162]; endocardial cushion fusion [GO:0003274]; epithelial to mesenchymal transition [GO:0001837]; gastrulation [GO:0007369]; growth plate cartilage chondrocyte growth [GO:0003430]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; inferior endocardial cushion morphogenesis [GO:1905317]; Langerhans cell differentiation [GO:0061520]; lens development in camera-type eye [GO:0002088]; lens fiber cell apoptotic process [GO:1990086]; lung lobe morphogenesis [GO:0060463]; mammary gland morphogenesis [GO:0060443]; membranous septum morphogenesis [GO:0003149]; miRNA transport [GO:1990428]; Notch signaling pathway [GO:0007219]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of angiogenesis [GO:0045766]; positive regulation of B cell tolerance induction [GO:0002663]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of tolerance induction to self antigen [GO:0002651]; regulation of gene expression [GO:0010468]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell proliferation [GO:0072091]; response to cholesterol [GO:0070723]; response to xenobiotic stimulus [GO:0009410]; secondary palate development [GO:0062009]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; trachea formation [GO:0060440]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tricuspid valve morphogenesis [GO:0003186]; vasculogenesis [GO:0001570]

caveola [GO:0005901]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; transforming growth factor beta ligand-receptor complex [GO:0070021]

activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; glycosaminoglycan binding [GO:0005539]; kinase activator activity [GO:0019209]; metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type II [GO:0005026]; type I transforming growth factor beta receptor binding [GO:0034713]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR011009;IPR000719;IPR017441;IPR001245;IPR008271;IPR045860;IPR000333;IPR017194;IPR015013;

2.10.60.10;1.10.510.10;

A0A5F5XXR7

MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVLEGHLLG

Felis catus (Cat) (Felis silvestris catus)

3.6.5.2

CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000256|ARBA:ARBA00000249}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00000249};

Cell membrane;Golgi apparatus;GTP-binding;Hydrolase;Membrane;Nucleotide-binding;Protein transport;Reference proteome;Transport

amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; establishment of protein localization to organelle [GO:0072594]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to cell surface [GO:0034394]; protein localization to cilium [GO:0061512]; protein transmembrane transport [GO:0071806]; regulation of cilium assembly [GO:1902017]; regulation of cytokinesis [GO:0032465]; regulation of early endosome to recycling endosome transport [GO:1902954]; regulation of endocytic recycling [GO:2001135]; regulation of multivesicular body size [GO:0010796]; regulation of protein localization to centrosome [GO:1904779]

centriolar satellite [GO:0034451]; centriole [GO:0005814]; cleavage furrow [GO:0032154]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; kinetochore microtubule [GO:0005828]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]

dynein light intermediate chain binding [GO:0051959]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Cytoplasmic vesicle, phagosome {ECO:0000256|ARBA:ARBA00004262}. Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}. Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004635}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004139}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004139}.

IPR027417;IPR005225;IPR001806;

3.40.50.300;

A0A5F5XZI9

MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRSTGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIIASHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLGGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQEPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKVMAGHGGGVMEREDENNYGDHGEKTEIKRIT

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000256|ARBA:ARBA00043880}.

4.6.1.2

CATALYTIC ACTIVITY: Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2; Evidence={ECO:0000256|RuleBase:RU003431};

cGMP biosynthesis;Coiled coil;Lyase;Membrane;Osteogenesis;Reference proteome;Signal;Transmembrane;Transmembrane helix

activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872]

cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]

adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR001054;IPR018297;IPR001828;IPR001170;IPR011009;IPR029787;IPR028082;IPR000719;IPR001245;

3.40.50.2300;3.30.70.1230;1.10.510.10;

A0A5F5XZJ3

MAPAWANVASRWALGCIGPPALGEMDPAGAASAFADNQPGSACPGGEDPSMPSETPQAETGSAGCPHLSGAHLGKGSLEKGPPGDKEAKERLWIRPDAPSKCSWQLGRPVTDSPHHHTVLTKSPQILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRCVIVMPEKMSTEKVDVLRALGAEIVRTPTTARFDSPESHVGVAWRLRNEIPNSHILDQYRNASNPLAHYDTTAEEILQQCDGKLDMLVASAGTGGTITGVARKLKEKCPGCKIIGVDPEGSILAEPEELNQSEQTVYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFAFARMLIAQEGLLCGGSAGSAMSVAVKAAQELQEGQRCVVILPDSVRNYMSKFLSDKWMMQKGFLKEEDFTVTKPWWWHLRVQELSLSAPLTVLPTVTCEHTIEILREKGFDQVPVVDESGVILGMVTLGNMLSSLLAGKVQPSDQVRKVLYKQFKQIRLTDPLGKLSHILETDHFALVVHEQIQSRDLALTGVVGGPSDHSNGRSSQRQTVFGVVTAIDLLNFVAARERDRKTKSGSTSEPRPAGATVQL

Felis catus (Cat) (Felis silvestris catus)

4.2.1.22

CATALYTIC ACTIVITY: Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine; Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384, ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22; Evidence={ECO:0000256|ARBA:ARBA00001175, ECO:0000256|RuleBase:RU361204};

COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000256|ARBA:ARBA00001933, ECO:0000256|RuleBase:RU361204};

PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. {ECO:0000256|ARBA:ARBA00005003}.

Amino-acid biosynthesis;CBS domain;Cysteine biosynthesis;Heme;Iron;Isopeptide bond;Lyase;Metal-binding;Pyridoxal phosphate;Reference proteome

blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; DNA protection [GO:0042262]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; hydrogen sulfide biosynthetic process [GO:0070814]; L-cysteine catabolic process [GO:0019448]; L-serine catabolic process [GO:0006565]; maternal process involved in female pregnancy [GO:0060135]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]

cytoplasm [GO:0005737]; nucleus [GO:0005634]

carbon monoxide binding [GO:0070025]; cystathionine beta-synthase activity [GO:0004122]; cysteine synthase activity [GO:0004124]; heme binding [GO:0020037]; L-cysteine desulfhydrase activity [GO:0080146]; modified amino acid binding [GO:0072341]; nitric oxide binding [GO:0070026]; nitrite reductase (NO-forming) activity [GO:0050421]; oxygen binding [GO:0019825]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; S-adenosyl-L-methionine binding [GO:1904047]; ubiquitin protein ligase binding [GO:0031625]

IPR046353;IPR000644;IPR046342;IPR005857;IPR001216;IPR001926;IPR036052;

3.40.50.1100;3.10.580.10;

A0A5F5XZJ7

MQTVVTPLTVGLGKVCPISVKSDLRGSYPRAGSPPPLPTALPCSAPCPRQSAPGHRQQAGTWEPRPCDQAKETGAPGSRPPVPPMELRPWLLWVVAAAGALVLLAADACGQKVYTNTWAVHIPGGPAVADSLARKHGFLNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQLGNVPWYSEACSSTLATTYSSGSQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVTLAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKMVTACLGEPSHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLHAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFTPQVLDTHYSTENDVEIIRASVCAPCHASCATCQGLAPTDCLSCPSHASLDPVEQTCSRQSQSSRESPEQQPPRPPPEVEAEPRARAELLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEEGPSDSEEDEGRGERTAFIKDQSAL

Felis catus (Cat) (Felis silvestris catus)

3.4.21.75

CATALYTIC ACTIVITY: Reaction=Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.; EC=3.4.21.75; Evidence={ECO:0000256|ARBA:ARBA00035756};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00001913};

Cell membrane;Cleavage on pair of basic residues;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Transmembrane;Transmembrane helix

blastocyst formation [GO:0001825]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; positive regulation of viral entry into host cell [GO:0046598]; regulation of cholesterol transport [GO:0032374]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058]; zymogen activation [GO:0031638]

cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]

heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Golgi apparatus, trans-Golgi network membrane {ECO:0000256|ARBA:ARBA00004393}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004393}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR006212;IPR008979;IPR009030;IPR034182;IPR002884;IPR000209;IPR036852;IPR023827;IPR022398;IPR023828;IPR015500;IPR032815;IPR038466;

2.60.120.260;3.30.70.850;3.40.50.200;

A0A5F5XZY3

MRVAGLGALPGLALPLLLAGVGVLTAASPPAPPLFNVSLDAAPELRWLPVLRHFDLDFVRAAMAHILGNRVPKWVHALIGKVVGELAAFLPQPFTDEIRGMCEVLNYDLADCLLLNLAYETTAFCTSIVAQDSKGHIYHGRNLDYPFGDFLRKLTVDVQFLKNGQVAFTGTTFIGYVGLWTGQSPRKFTISGDERDEGWWWENVIAALFQRHSVISWLIRTMRYMFHPDFCHLNETLSESENFDAAVYKLANTPLIAGVYYIVGGASPREGVVITRNRNGPADIWPLDPLNGAWFRVETNYDHWKPVPEKDDRRTPAMKALNATGQENLSLETLFQVLSVFPVCNNYTIYTTVMSAANPEKYTTRIRNLG

Felis catus (Cat) (Felis silvestris catus)

3.5.1.23; 3.5.1.60

CATALYTIC ACTIVITY: Reaction=H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine; Xref=Rhea:RHEA:17505, ChEBI:CHEBI:15377, ChEBI:CHEBI:15897, ChEBI:CHEBI:57560, ChEBI:CHEBI:57603; EC=3.5.1.60; Evidence={ECO:0000256|ARBA:ARBA00036451}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17506; Evidence={ECO:0000256|ARBA:ARBA00036451}; CATALYTIC ACTIVITY: Reaction=H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine; Xref=Rhea:RHEA:45456, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57603, ChEBI:CHEBI:85263; Evidence={ECO:0000256|ARBA:ARBA00036827}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45457; Evidence={ECO:0000256|ARBA:ARBA00036827}; CATALYTIC ACTIVITY: Reaction=H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine; Xref=Rhea:RHEA:41291, ChEBI:CHEBI:15377, ChEBI:CHEBI:18262, ChEBI:CHEBI:57756, ChEBI:CHEBI:72956; Evidence={ECO:0000256|ARBA:ARBA00035891}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41292; Evidence={ECO:0000256|ARBA:ARBA00035891}; CATALYTIC ACTIVITY: Reaction=H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate; Xref=Rhea:RHEA:45064, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57603, ChEBI:CHEBI:71464; Evidence={ECO:0000256|ARBA:ARBA00036896}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45065; Evidence={ECO:0000256|ARBA:ARBA00036896}; CATALYTIC ACTIVITY: Reaction=H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine; Xref=Rhea:RHEA:38891, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence={ECO:0000256|ARBA:ARBA00035825}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38892; Evidence={ECO:0000256|ARBA:ARBA00035825}; CATALYTIC ACTIVITY: Reaction=H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate; Xref=Rhea:RHEA:45452, ChEBI:CHEBI:15377, ChEBI:CHEBI:30807, ChEBI:CHEBI:57603, ChEBI:CHEBI:85262; Evidence={ECO:0000256|ARBA:ARBA00036924}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45453; Evidence={ECO:0000256|ARBA:ARBA00036924}; CATALYTIC ACTIVITY: Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine; Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868, ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23; Evidence={ECO:0000256|ARBA:ARBA00000595}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20857; Evidence={ECO:0000256|ARBA:ARBA00000595};

PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000256|ARBA:ARBA00004872}.

Autocatalytic cleavage;Fatty acid metabolism;Glycoprotein;Hydrolase;Lipid degradation;Lipid metabolism;Lysosome;Membrane;Reference proteome;Signal

fatty acid metabolic process [GO:0006631]; lipid catabolic process [GO:0016042]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; sphingosine metabolic process [GO:0006670]

lysosome [GO:0005764]; membrane [GO:0016020]

ceramidase activity [GO:0102121]; DNA-binding transcription factor binding [GO:0140297]; fatty acid amide hydrolase activity [GO:0017064]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; N-(long-chain-acyl)ethanolamine deacylase activity [GO:0047412]; N-acylsphingosine amidohydrolase activity [GO:0017040]

SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371, ECO:0000256|PIRNR:PIRNR017632}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR016699;IPR029130;

A0A5F5Y1G6

MESALPAAGFLYWVGAGTVAYLALRISCSLFTALRVWGLSHEVGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKIVLISRSQDKLNQVSSEIREKFKVETMTIAVDFASEDIYDKIKTSLAGLKIGVLVNNVGVSYEYPEYFLDVPDLDNTIKKLINVNVLSVCKMTRLVLPGMVERSKGAILNISSASGLVPVPLLAMYSATKAFVDFFSQCLHEEYRSKGIFVQWHPVLLTLKDQIEKNTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRRKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRINLTFRTVYPDPRGARW

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. {ECO:0000256|ARBA:ARBA00037337}.

1.1.1.330; 1.1.1.62

CATALYTIC ACTIVITY: Reaction=(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+); Xref=Rhea:RHEA:39323, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73852, ChEBI:CHEBI:76415; Evidence={ECO:0000256|ARBA:ARBA00036946}; CATALYTIC ACTIVITY: Reaction=(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+); Xref=Rhea:RHEA:39459, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:73863, ChEBI:CHEBI:76460; Evidence={ECO:0000256|ARBA:ARBA00036361}; CATALYTIC ACTIVITY: Reaction=(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+); Xref=Rhea:RHEA:39311, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:71481, ChEBI:CHEBI:76411; Evidence={ECO:0000256|ARBA:ARBA00036851}; CATALYTIC ACTIVITY: Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence={ECO:0000256|ARBA:ARBA00035946}; CATALYTIC ACTIVITY: Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence={ECO:0000256|ARBA:ARBA00036215}; CATALYTIC ACTIVITY: Reaction=3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+); Xref=Rhea:RHEA:39151, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:71407, ChEBI:CHEBI:76374; Evidence={ECO:0000256|ARBA:ARBA00035933}; CATALYTIC ACTIVITY: Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:48680, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85440, ChEBI:CHEBI:90725; EC=1.1.1.330; Evidence={ECO:0000256|ARBA:ARBA00036602};

COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|ARBA:ARBA00001954};

PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|ARBA:ARBA00005194}.; PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000256|ARBA:ARBA00037929}.

Lipid biosynthesis;Lipid metabolism;Oxidoreductase;Reference proteome;Steroid biosynthesis

extracellular matrix organization [GO:0030198]; fatty acid elongation, saturated fatty acid [GO:0019367]; positive regulation of cell-substrate adhesion [GO:0010811]; steroid biosynthetic process [GO:0006694]

endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; fatty acid elongase complex [GO:0009923]

collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; oxidoreductase activity [GO:0016491]; very-long-chain 3-oxoacyl-CoA reductase activity [GO:0141040]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR027450;IPR037151;IPR036291;IPR005123;IPR020904;IPR002347;

2.60.120.590;3.40.50.720;

A0A5F5Y3F5

MCAAEVDHQVAQRYLLKRRLGKGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREIMLLQQLGDHPNIIRLLDVIRAENDRDIYLVFESMDTDLNAVICKGRLLKDVHKRFIMYQLLRATKFIHSGGVIHRDQKPSNILLDASCLVKLCDFGLARPLGGLPEGPEGPALTDYVATRWYRAPEVLLSSSWYTPGVDMWSLGCVLGEMLRGRPLFPGTSTLHQLELILETIPPPSKEDLLALSSSFSASVLPCLGSRPRQTLDALLPPDTPPEALDLLKGLLVFAPGKRLSAAQALRHPYVQRFHCPAREQTLDAAVRLPVLEGVQLSAPEYRSRVYQMILERRGGGPVPRGKGPGGTPPGQARLRSPRAVPQLSPGSPSQKPGADAQSSLGQQSAHDVPCGAENLPRPDVAPLLQPPPPGGLGRAERPPGVTAQAPSGHSWVKPSVKGAAPSLASQAAARVAVQALIRSDWNLGRGVRASGARRVPRGLPADARPEPRPGRRMFGASAWQGAQGASRAALGGYSQAYGTVCHSALGRLLLLPPRA

Felis catus (Cat) (Felis silvestris catus)

2.7.11.24

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000494}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24; Evidence={ECO:0000256|ARBA:ARBA00000088};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

DNA damage response [GO:0006974]; dopamine uptake [GO:0090494]; endoplasmic reticulum organization [GO:0007029]; intracellular signal transduction [GO:0035556]; negative regulation of cell migration [GO:0030336]; phosphorylation [GO:0016310]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of metaphase/anaphase transition of meiosis I [GO:1905188]; positive regulation of spindle assembly [GO:1905832]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to ciliary transition zone [GO:1904491]; regulation of autophagy [GO:0010506]; regulation of cilium assembly [GO:1902017]; regulation of COPII vesicle coating [GO:0003400]

autophagosome [GO:0005776]; cell-cell junction [GO:0005911]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; meiotic spindle [GO:0072687]; nucleus [GO:0005634]

ATP binding [GO:0005524]; chromatin binding [GO:0003682]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR003527;IPR000719;IPR017441;

1.10.510.10;

A0A5F5Y3G7

MPRAPRCRAVRALLRGRYREVLPLATFMRRLGPQGRRLVRRGDPAAFRALVAQCLVCVPWDARPAPVGPSFRQVGCPGDPARACRGGRGRAARSGPGAPPSPAPRDPSTPQVSCLKELVARVVQRLCERGARNVLAFGFALLDGARGGPPVAFTTSVRSYLPNTVTETLRGSGAWGLLLRRVGDDVLAHLLTRCALYVLVAPSCAYQVCGPPLYDLCAPAATRPLATSGHRPGTRMDLRPTRQARNAGARRRRGAGGSSPPLAKRPRRDVTPEPERGPDRPSSRHPPGRAHGLSGGEPGAVTSARAAAEANSGEGGPPGTRLTSAGAQLSRPQGVPLSHLSHPETKHFLYCPGGKERLRPSFLLSALRPSLTGARTLLEAIFLGSKSPRPGAARRTRRLPARYWRMRPLFRELLANHARCPYDALLRTHCPLRAPAPAEGSSRGVGGGAGGCALGRPPGAPGGLLQLLRQHSSPWQVYAFLRACLCRLVPAGLWGSGHNRRRFLRNVKKFVSLGKHAKLSLQELTWKMRVQDCAWLRGSPGARCVPAAEHRRREEVLAKLLCWLMGTYVVELLKSFFYVTETTFQKNRLFFYRKRIWSQLQSIGIRQHFNSVHLRELSEAEVRRHQEARPTLLTSKLRFLPKPSGLRPIVNMDYVVGARTFRRDKKVRHLTSQVKNLFSVLNYERARRPSLLGASVLGMDDIHRVWRSFVLRVRAQDPAPQLYFVKVDVTGAYDALPQDKLVEVIANVIRPQENTYCVRHYAVVQRTAQGHVRKSFKRHVSTFVDLQPYMRQFVEHLQETSSLRDAVVIEQSSSLNETGHSLFHLFLRLVHNHVIRIGGKSYVQCQGIPQGSILSTLLCSLCYGDMESRLFSGIQQDGVLLRLVDDFLLVTPHLAQAQAFLRTLVSGVPEYGCTANLQKTAVNFPVDTGAPGSAAPLQLPAHCLFPWCGLLLDTRTLEVFCDYSSYAQTSIRSSLTFSQGTRPGRNMRRKLLAVMRLKCCAVFLDLQVNSIHTVYTNIYKIFLLQAYRFHACVLQFPFNQPVRKNPSFFLRVIADTASRCYSLLKAKNTGVRSEPARLAGSGGSLGVPAKPRLLARLLPIPGAVCAPGAPCRTCRQRSRRGGEGGGLREAGSCRLQLRWPLPTAHWPLTRPLPEGSGPVCWECDGHSRPPPGGHLRQARARSRLSPATCARAGQGSAGGRPPHRLPIPGEREGRPRGPLARLCLGLPVCSSAFLRAPPRMVSAPRGLSRRFWSVAAQAEPCPQGPCCFPFCASFFGKVEGSISAIRVPGACVGAVLETKSPV

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. {ECO:0000256|RuleBase:RU365061}.

2.7.7.49

CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000256|ARBA:ARBA00024557, ECO:0000256|RuleBase:RU365061};

Chromosome;Magnesium;Metal-binding;Nucleotidyltransferase;Nucleus;Reference proteome;Ribonucleoprotein;RNA-directed DNA polymerase;Telomere;Transferase

cellular response to hypoxia [GO:0071456]; DNA strand elongation [GO:0022616]; establishment of protein localization to telomere [GO:0070200]; mitochondrion organization [GO:0007005]; negative regulation of cellular senescence [GO:2000773]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of protein stability [GO:0031647]; replicative senescence [GO:0090399]; siRNA processing [GO:0030422]; siRNA transcription [GO:0140745]; telomere maintenance via telomerase [GO:0007004]

chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; PML body [GO:0016605]; telomerase catalytic core complex [GO:0000333]; TERT-RMRP complex [GO:1990572]

metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; RNA-dependent RNA polymerase activity [GO:0003968]; telomerase RNA binding [GO:0070034]; telomerase RNA reverse transcriptase activity [GO:0003721]; telomeric DNA binding [GO:0042162]; template-free RNA nucleotidyltransferase [GO:0098680]; transcription coactivator binding [GO:0001223]; tRNA binding [GO:0000049]

SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574, ECO:0000256|RuleBase:RU365061}. Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322, ECO:0000256|RuleBase:RU365061}. Nucleus, nucleolus {ECO:0000256|RuleBase:RU365061}. Nucleus, nucleoplasm {ECO:0000256|RuleBase:RU365061}. Nucleus {ECO:0000256|RuleBase:RU365061}. Cytoplasm {ECO:0000256|RuleBase:RU365061}. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT. {ECO:0000256|RuleBase:RU365061}.

DOMAIN: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity. {ECO:0000256|RuleBase:RU365061}.; DOMAIN: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis. {ECO:0000256|RuleBase:RU365061}.; DOMAIN: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers. {ECO:0000256|RuleBase:RU365061}.

IPR043502;IPR000477;IPR021891;IPR003545;IPR049139;

1.10.132.70;1.10.357.90;

A0A5F5Y3Q7

MVLYTAPFPNSCLSALHAVSWALIFPCYWLLDRLVASFIPIACQKRQRADDPCYLQLLCTVLFAPVYLALLVASLPFAFVGFLLWSPLQSARRPYIYSRLEDKGPAGGAALLSEWKGTGPGKSFCFATANLCLLPDSLARLNNVFNTQARAKEIGQRIRNGASRPQIKIYIDSPTNTSISAASFSSLVSPQGSDGVARAVPGSIKRTASVEYKGDSGHHSSDEAANGPASGDPAEGGSLEDACIVRIGGEDGGRPPEADDSASGGQARNGAGGGSRGQTPNHSQRDGDSGSLGSPSASRESLVKARDGGSGEPGATNSKLPYKASGVKKAAARKRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAAAKLKAQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLFFASRYPIMDVAYHCYPNGRGSDGLASKGALFLKVQVGSTPQDQRIVGYISCTHLHALPEDSAIRCEQLDLLQDWLADFRKSTSSSSTANPEELVVFDVVCGDFNFDNCSSDDKLEQQHSLFTHYKDPCRLGPGEEKSWAIGTMLDTDNLYDEDVCTPDNLQKVLETEEGRREYLAFPTSKSPGAGQKGRKDLLKGNGRRIDYMLYAEEGLCPDWKAVSRVGRAMPIDRGSRALYPSAALSSSLKTRSVSLRVLGAHGMLPFLCLREDPG

Felis catus (Cat) (Felis silvestris catus)

3.1.4.12

CATALYTIC ACTIVITY: Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:39923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74001, ChEBI:CHEBI:75216, ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00035963}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39924; Evidence={ECO:0000256|ARBA:ARBA00035963}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000008}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; Evidence={ECO:0000256|ARBA:ARBA00000008}; CATALYTIC ACTIVITY: Reaction=H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine; Xref=Rhea:RHEA:45644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72959, ChEBI:CHEBI:78646, ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00023739}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45645; Evidence={ECO:0000256|ARBA:ARBA00023739}; CATALYTIC ACTIVITY: Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; Evidence={ECO:0000256|ARBA:ARBA00023999}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254; Evidence={ECO:0000256|ARBA:ARBA00023999}; CATALYTIC ACTIVITY: Reaction=a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:84410, ChEBI:CHEBI:85171, ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00036120}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45297; Evidence={ECO:0000256|ARBA:ARBA00036120}; CATALYTIC ACTIVITY: Reaction=an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64583, ChEBI:CHEBI:83273, ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00036372}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45301; Evidence={ECO:0000256|ARBA:ARBA00036372};

PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004760}.; PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.

Lipid metabolism;Membrane;Reference proteome;Sphingolipid metabolism;Transmembrane;Transmembrane helix

BMP signaling pathway [GO:0030509]; bone growth [GO:0098868]; bone mineralization [GO:0030282]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to magnesium ion [GO:0071286]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to peptide [GO:1901653]; cellular response to redox state [GO:0071461]; cellular response to tumor necrosis factor [GO:0071356]; ceramide metabolic process [GO:0006672]; chondrocyte development involved in endochondral bone morphogenesis [GO:0003433]; collagen metabolic process [GO:0032963]; dentinogenesis [GO:0097187]; DNA biosynthetic process [GO:0071897]; endochondral ossification [GO:0001958]; extracellular matrix assembly [GO:0085029]; G1 to G0 transition [GO:0070314]; hematopoietic progenitor cell differentiation [GO:0002244]; lung alveolus development [GO:0048286]; mitotic nuclear division [GO:0140014]; multicellular organism growth [GO:0035264]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; peptide hormone secretion [GO:0030072]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; polysaccharide transport [GO:0015774]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of cartilage development [GO:0061035]; regulation of leukocyte migration [GO:0002685]; regulation of protein phosphorylation [GO:0001932]; sphingolipid mediated signaling pathway [GO:0090520]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]

cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi cis cisterna [GO:0000137]; plasma membrane [GO:0005886]

identical protein binding [GO:0042802]; neutral sphingomyelin phosphodiesterase activity [GO:0061751]; phosphatidic acid binding [GO:0070300]; phosphatidylserine binding [GO:0001786]; sphingomyelin phosphodiesterase activity [GO:0004767]

IPR036691;IPR005135;IPR038772;IPR017766;

3.60.10.10;

A0A5F5Y3W1

MPGPRLAPPTLPGPRPAAEGRGAPGGAALASGRGIRRGVTGKLVRVPGVSPVFPGARPAGAPAPRLPPSFTAHQIPPSGSAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHAFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSSESVGTMKATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

Apoptosis;ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Transferase

canonical Wnt signaling pathway [GO:0060070]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; epithelial cell proliferation [GO:0050673]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; organ growth [GO:0035265]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; primitive hemopoiesis [GO:0060215]; protein import into nucleus [GO:0006606]; protein localization to centrosome [GO:0071539]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; regulation of MAPK cascade [GO:0043408]

centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR024205;IPR049568;IPR036674;IPR000719;IPR017441;IPR011524;

1.10.287.4270;4.10.170.10;1.10.510.10;

A0A5F5Y3X7

MRAGPGAGLQDGRAGTGAPVAQPERCAPSQSACQTASSPAARLAALRRRPFLMLAPPASETAVPMSQAEADLALRPPPPLAAAGPPRLGPPPRRARRFSGKAETRPRSSRLSRRSSVDLGLLSSWSQPASPAPEPPEPPDSAEPGPAKSPPPSCPEPPEGTWTGGAPAKAADSARPELAVSAGGPGSREPPRVPEAAARERQREQEEKEDTETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRTERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLKGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHTRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERWGGGGRVGVGSGAGAGVGGRRQGSAHRSTPPRFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPAPGPPPAAVPKTPGPPSVFPPEPEEPEADQHQSFLLRHASYSSTTSDCETDGYLSSSGFLDASDPAFQPPGGVPSSPAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGRMRRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERAGFLSRIREIIQRVETLLKRDTGPVEAAEDPLGSQVEPAPLPALSDPLPDPSRELQSSTSLEQSCWAAFSTSPSSPGTPLSPGSLFSPGTPVSPSPIFPITSPPCCPSPVPFSQVSSNLSPQTLSSPLAFSPSAAQLPGPPSQSPPSCLLPSPPAFSPSCSQVTITPPSFPHCPSASPLPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPAPLPSLPLPPPPAPCGQDRPSPPTAETESEVPPNPARPLLGEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQPTFPTLSSSLKPPTPQLTSESSDTEDSAGGGPEAREALAESDRAAEGLVAGAEEEGDDGKEPRGGGSPPPQSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAQLQSLRQKHLSEVEALQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRMGP

Felis catus (Cat) (Felis silvestris catus)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Transferase

aldosterone secretion [GO:0035932]; calcium ion homeostasis [GO:0055074]; cellular response to xenobiotic stimulus [GO:0071466]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; ERK1 and ERK2 cascade [GO:0070371]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; monoatomic ion homeostasis [GO:0050801]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of sodium ion transport [GO:0010766]; phosphorylation [GO:0016310]; positive regulation of potassium ion import across plasma membrane [GO:1903288]; potassium ion transmembrane transport [GO:0071805]; protein kinase C signaling [GO:0070528]; protein localization [GO:0008104]; regulation of blood pressure [GO:0008217]; regulation of potassium ion export across plasma membrane [GO:1903764]; renal sodium ion absorption [GO:0070294]; response to dietary excess [GO:0002021]; sodium ion transmembrane transport [GO:0035725]

bicellular tight junction [GO:0005923]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]

ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; potassium channel inhibitor activity [GO:0019870]; protein serine/threonine kinase activity [GO:0004674]

IPR011009;IPR024678;IPR000719;IPR008271;

1.10.510.10;

A0A5F5Y512

MKKSRSVMAVTADDNVKDYLECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQEGFDVENGPSPGRSPLDPQASSSSGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTVLTNLHGASNKRSPAAASQPPVSRVNLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLEEEDSEGPEKEGEGHDYFSSTKTLCVIDPEHRESLGGTDVDIVTEDKSPIDT

Felis catus (Cat) (Felis silvestris catus)

3.1.4.-

CATALYTIC ACTIVITY: Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53; Evidence={ECO:0000256|ARBA:ARBA00033681}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25278; Evidence={ECO:0000256|ARBA:ARBA00033681};

COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000256|RuleBase:RU363067}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};

PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004703}.

cAMP;cGMP;Hydrolase;Metal-binding;Reference proteome

cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; neutrophil homeostasis [GO:0001780]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of type II interferon production [GO:0032729]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell contraction [GO:0086004]; T cell receptor signaling pathway [GO:0050852]

centrosome [GO:0005813]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; gamma-tubulin complex [GO:0000930]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; synaptic vesicle [GO:0008021]; voltage-gated calcium channel complex [GO:0005891]; Z disc [GO:0030018]

3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calcium channel regulator activity [GO:0005246]; cAMP binding [GO:0030552]; gamma-tubulin binding [GO:0043015]; metal ion binding [GO:0046872]; transmembrane transporter binding [GO:0044325]

IPR003607;IPR040844;IPR023088;IPR002073;IPR036971;IPR023174;

1.10.1300.10;

A0A5F5Y6J1

MDQREILQKFLDEAQNKKSNKEEFANEFLWLKRQSTKYKADKTYPTTVAERPKNIKKNRYKDILPYDHSLVELSLITSDEDSNYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEFEMGKKKCERYWTEPGELQLQVGPFSISCEAENRKSDYIIRTLKAKFNSETRTLYQFHYRNWPDHDVPSSIDPILELIWDMRSYQEDDHVPVCIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSIFSLIQEMRTQRPSFVQTQEQYELVYKAVLELFKRQMDVIRGKKSGTEIQAKYSVLEQNPTLEAESYSNLPKSGIKEAKMVKQQNKQKIRLKSADASSFGPRTPEISEKEGLVLHPAEQSSSFDILELNCGCNKNADTTEKWEPKAFPIVGEPLQKHQSLDWSPVLFNSKPANVAGGYFNSKGPITRAKSTSFELMQQRDTKELDIEENVLCLEPQPHNSPLGRARKAMHVSSAELNYSLPSDSRRQTGNASNAKQQDASAVQVHSYMSLEDPFFSSLSPSSTGSKMSLDLPERPDGTALPRSPLPASSTTLFSCYNSHDSLALSSPTGHPPPLDQETAVVATSPRIDDDIPPPLPERTPESFIVVEGEFPQTVPKSLSSAVKVIIGTSLECSGTSESKKSDDSVRLRPTKSVKLRSPQSDRHQDRSSPPPPPLPERTLESFLLADEDCMQAQSIRTYSTSCPNTMENSTSSKQTLKTPGKSFTRTKSLKILRNMKKSVSNSSPANKPADSVQSNRSNSFLNFGFANRFSKPKGPRKPPATWNI

Felis catus (Cat) (Felis silvestris catus)

3.1.3.48

Hydrolase;Reference proteome

cellular response to muramyl dipeptide [GO:0071225]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of T cell activation [GO:0050868]; negative regulation of tumor necrosis factor production [GO:0032720]; phosphoanandamide dephosphorylation [GO:0035644]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granzyme B production [GO:0071663]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; regulation of leukocyte migration [GO:0002685]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]

cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; nucleus [GO:0005634]

kinase binding [GO:0019900]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; SH3 domain binding [GO:0017124]

IPR029021;IPR047170;IPR047253;IPR000242;IPR016130;IPR003595;IPR000387;

3.90.190.10;

A0A5F5Y795

MTAPPPPPLAWGGRGAGVATSGRMWGSAAGRHVTRPGDKWTARRGSAQSPSPLLPRVPRRRSQHPAPQRAPSAGRMERPQPDSMPQDLSEALKEATKEVHVQAENAEFMKNFQKGQVTRKGFKLVMASLYHIYVALEEQIERNKENPAYAPLYFPEELHRRAALERDMAFWYGPRWEDAIPYTQATRHYVRRLHEVGRKEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGVDFFTFPNVASATKFKQLYRSRMNTLEMTPEVRQRVIEEAKAAFLLNIQLFEELQELLGQDAEDQSPSQAPGLRRRVGSGARGEGPPGDGRCGRGAGPSRVSRAPLGCPVFRVFRVTSRAQAQGRHSGARGQPCSLSTPVSPSLKSRAVNWFSFTVTPSPRPFHGF

Felis catus (Cat) (Felis silvestris catus)

FUNCTION: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000256|ARBA:ARBA00037361}.

1.14.14.18

CATALYTIC ACTIVITY: Reaction=heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:21764, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17245, ChEBI:CHEBI:29033, ChEBI:CHEBI:57618, ChEBI:CHEBI:57991, ChEBI:CHEBI:58210, ChEBI:CHEBI:60344; EC=1.14.14.18; Evidence={ECO:0000256|ARBA:ARBA00036473}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21765; Evidence={ECO:0000256|ARBA:ARBA00036473};

Endoplasmic reticulum;Heme;Iron;Metal-binding;Oxidoreductase;Reference proteome

cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to cisplatin [GO:0072719]; cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; epithelial cell apoptotic process [GO:1904019]; erythrocyte homeostasis [GO:0034101]; heme catabolic process [GO:0042167]; heme oxidation [GO:0006788]; intracellular iron ion homeostasis [GO:0006879]; macroautophagy [GO:0016236]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of macroautophagy [GO:0016242]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of macroautophagy [GO:0016239]; positive regulation of smooth muscle cell proliferation [GO:0048661]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; wound healing involved in inflammatory response [GO:0002246]

cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]

heme binding [GO:0020037]; heme oxygenase (decyclizing) activity [GO:0004392]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00037869}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00037869}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037869}.

IPR002051;IPR016053;IPR016084;IPR018207;

1.20.910.10;

A0A5F7Z806

MRGARGAWDFLCVLLFLLHVQTGSSQPSVSPGEPSPPSIHPAKSELIVRVGNEIRLLCIDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSSSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTSYSLKGCQGKPLPKDLRFVPDPKAGITIKSVKRAYHRLCLHCSADQEGKSVLSDKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRGNSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNASIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNASGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAESALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSMRINSVGSTASSSQPLLVHDDV

Macaca mulatta (Rhesus macaque)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171, ECO:0000256|PIRNR:PIRNR500951};

ATP-binding;Cell membrane;Disulfide bond;Glycoprotein;Immunoglobulin domain;Kinase;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase;Ubl conjugation

actin cytoskeleton organization [GO:0030036]; B cell differentiation [GO:0030183]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; digestive tract development [GO:0048565]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; Fc receptor signaling pathway [GO:0038093]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell migration [GO:0035701]; immature B cell differentiation [GO:0002327]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; lamellipodium assembly [GO:0030032]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; mast cell proliferation [GO:0070662]; megakaryocyte development [GO:0035855]; melanocyte adhesion [GO:0097326]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of developmental process [GO:0051093]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reproductive process [GO:2000242]; ovarian follicle development [GO:0001541]; phosphorylation [GO:0016310]; positive regulation of cell migration [GO:0030335]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; regulation of cell shape [GO:0008360]; response to radiation [GO:0009314]; spermatid development [GO:0007286]; stem cell differentiation [GO:0048863]; T cell differentiation [GO:0030217]

cell-cell junction [GO:0005911]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; fibrillar center [GO:0001650]; receptor complex [GO:0043235]

ATP binding [GO:0005524]; cytokine binding [GO:0019955]; growth factor binding [GO:0019838]; metal ion binding [GO:0046872]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; SH2 domain binding [GO:0042169]; stem cell factor receptor activity [GO:0005020]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000311}.

IPR007110;IPR036179;IPR013783;IPR003599;IPR003598;IPR013151;IPR011009;IPR000719;IPR017441;IPR027263;IPR001245;IPR008266;IPR020635;IPR001824;

2.60.40.10;1.10.510.10;

A0A5F7Z9G9

MSEAGGAGPGGCGAGAGAGAGPGALPPQPVVLPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKSVLNHTFLHDGFSKMTHHTLNTSLSLRAFTLVCKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVISPPPVAGTISYNSTSSSLEQSNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKRPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK

Macaca mulatta (Rhesus macaque)

2.3.1.48

CATALYTIC ACTIVITY: Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000256|ARBA:ARBA00024456}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21993; Evidence={ECO:0000256|ARBA:ARBA00024456};

Bromodomain;Cytoplasm;Cytoskeleton;Nucleus;Reference proteome;Transcription;Transcription regulation

cellular response to insulin stimulus [GO:0032869]; chromatin remodeling [GO:0006338]; gluconeogenesis [GO:0006094]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of centriole replication [GO:0046600]; negative regulation of rRNA processing [GO:2000233]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glycolytic process [GO:0045821]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]

A band [GO:0031672]; actomyosin [GO:0042641]; ATAC complex [GO:0140672]; centrosome [GO:0005813]; cytosol [GO:0005829]; I band [GO:0031674]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]

chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K9 acetyltransferase activity [GO:0043992]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; protein kinase binding [GO:0019901]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]

SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR016181;IPR001487;IPR036427;IPR018359;IPR037800;IPR016376;IPR000182;IPR009464;

3.40.630.30;1.20.920.10;

A0A5F7ZBV5

MEHKEVVLLLLLFLKSGQGEPLDDYVNTKGASLFSITKKQLGAGSIEECAAKCEEEEEFTCRSFQYHSKEQQCVIMAENRKSSIVFRMRDVVLFEKKVYLSECKTGNGKSYRGTMSKTRTGITCQKWSSTSPHRPKFSPATHPSEGLEENYCRNPDNDGQGPWCYTTDPEERFDYCDIPECEDECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDGEPRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGDVAVTVSGHTCQRWSAQTPHTHNRTPENFPCKNLDENYCRNPDGEKAPWCYTTNSQVRWEYCKIPSCESSPVSTEPLDPTAPPELTPVVQECYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHWHEKTPENFPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEGSVAAPPPVAQLPDAETPSEEDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHSHRIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLFDYCDVPQCAASSFDCGKPQVEPKKCPGRVVGGCVAYPHSWPWQISLRTRLGMHFCGGTLISPEWVLTAAHCLEKSSRPSFYKVILGAHREVHLEPHVQEIEVSKMFSEPARADIALLKLSSPAIITDKVIPACLPSPNYVVADRTECFITGWGETQGTYGAGLLKEARLPVIENKVCNRYEFLNGRVKTTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN

Macaca mulatta (Rhesus macaque)

FUNCTION: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000256|ARBA:ARBA00025229, ECO:0000256|PIRNR:PIRNR001150}.

3.4.21.7

CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.; EC=3.4.21.7; Evidence={ECO:0000256|ARBA:ARBA00000717, ECO:0000256|PIRNR:PIRNR001150};

Blood coagulation;Disulfide bond;Fibrinolysis;Hemostasis;Hydrolase;Kringle;Phosphoprotein;Protease;Reference proteome;Secreted;Serine protease;Signal;Tissue remodeling;Zymogen

biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; proteolysis [GO:0006508]; tissue remodeling [GO:0048771]

external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]

apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]

SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|PIRNR:PIRNR001150}.

IPR000001;IPR013806;IPR018056;IPR038178;IPR003609;IPR023317;IPR009003;IPR043504;IPR001314;IPR001254;IPR018114;IPR033116;

3.50.4.10;2.40.20.10;2.40.10.10;

A0A5F7ZD13

MLLPQASQASRGSGSTGCSLMAPELDTAQGAKMRRGAGAARGRASWCPAVALLWLAAVPGWPRASGVLSRRHWPVPYKRFDSRPKPDPYCQAKYTFCPTGSPIPVMEGDDDIEVFRLQAPVWEFKYGDLLGHLKIMHDAIGFRSTLTGKNYTMEWYELFQLGNCTFPHLRPEMDAPFWCNQGAACFFEGIDDVHWKENGTLVKVATISGNMFNQMAKWVKQDNETGIYYETWNVKASPEKGAETWFDSYDCSQFVLRTFSKLAEFGAEFKNIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLGLAIKRFYYPFKPHLSTKEFLLNLLQIFDAVIVHREFYLFYNFEYWFLPMKFPFIKITYEEIPLPNKNKTLSGL

Macaca mulatta (Rhesus macaque)

FUNCTION: Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation. {ECO:0000256|ARBA:ARBA00044494}.

3.1.2.22

CATALYTIC ACTIVITY: Reaction=2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77599, ChEBI:CHEBI:139150, ChEBI:CHEBI:139152, ChEBI:CHEBI:197411; Evidence={ECO:0000256|ARBA:ARBA00044481}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77600; Evidence={ECO:0000256|ARBA:ARBA00044481}; CATALYTIC ACTIVITY: Reaction=2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77607, ChEBI:CHEBI:44859, ChEBI:CHEBI:197411, ChEBI:CHEBI:197415; Evidence={ECO:0000256|ARBA:ARBA00044455}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77608; Evidence={ECO:0000256|ARBA:ARBA00044455}; CATALYTIC ACTIVITY: Reaction=2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77603, ChEBI:CHEBI:197411, ChEBI:CHEBI:197412, ChEBI:CHEBI:197414; Evidence={ECO:0000256|ARBA:ARBA00044460}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77604; Evidence={ECO:0000256|ARBA:ARBA00044460}; CATALYTIC ACTIVITY: Reaction=2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77611, ChEBI:CHEBI:197411, ChEBI:CHEBI:197413, ChEBI:CHEBI:197416; Evidence={ECO:0000256|ARBA:ARBA00044453}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77612; Evidence={ECO:0000256|ARBA:ARBA00044453}; CATALYTIC ACTIVITY: Reaction=2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol); Xref=Rhea:RHEA:77619, ChEBI:CHEBI:77717, ChEBI:CHEBI:197411, ChEBI:CHEBI:197425; Evidence={ECO:0000256|ARBA:ARBA00044472}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77620; Evidence={ECO:0000256|ARBA:ARBA00044472}; CATALYTIC ACTIVITY: Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:74151; EC=3.1.2.22; Evidence={ECO:0000256|ARBA:ARBA00037021}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19234; Evidence={ECO:0000256|ARBA:ARBA00037021};

Glycoprotein;Reference proteome

brain development [GO:0007420]; glycosylation [GO:0070085]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; neurogenesis [GO:0022008]; retrograde transport, endosome to Golgi [GO:0042147]; signal peptide processing [GO:0006465]; visual perception [GO:0007601]

cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; vacuolar lumen [GO:0005775]

bis(monoacylglycero)phosphate synthase activity [GO:0160121]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; mannose binding [GO:0005537]

IPR026138;

A0A5F7ZD59

MAAAAAAALAAADPPPAMPQAAGAGGPTARRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNRHYKHFGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHTYTGIIHAFKTIYAQEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLFQKKAVASFPRTVLSRGMDNRYLVLAVSTVQNKEGNCEKHLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILYPDILISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNASTDFPQMQLSLPSDSSKDNSTCNIEVVKSMDIEESIWSPRFGLKGKIDVTVGVKIHRGCKTKYKIMPLELKTGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVSANHLDKRELLKLRNQMAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQMGNCALYSRAVEQQMDGSSVPIVMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIGHLIRTEHVKTICDGQYLHNFQRKHGAIPVTNLLAGDRVIVSGEERSLFALSRGYVKEINTTTVTCLLDRNLSVLPESILFRLDQEEKSCDIETPLGNLSKLMENTFVSKKLRDLIIDFREPQFTSYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLVVGMPGTGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQTQKVHPAIQQFTEQEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQSKNAVVQLTVQYRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLPHFKDVKLDLEFYADYSDNPWLMGVFEPNNPVCFLNTDKVPAPEQVEKGGVSNITEAKVIVFLTSIFIKAGCSPSDIGIIAPYRQQLKIINDLLAHSSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSLNCYPPLEKLLNHLNSEKLIIDLPSREHGSLCHILGDFQRE

Macaca mulatta (Rhesus macaque)

3.6.4.12

CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00001665};

COFACTOR: Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000256|ARBA:ARBA00001966};

4Fe-4S;ATP-binding;DNA damage;DNA repair;DNA replication;Hydrolase;Iron;Iron-sulfur;Membrane;Metal-binding;Mitochondrion;Multifunctional enzyme;Nucleotide-binding;Nucleus;Reference proteome;Repeat;Transmembrane;Transport

base-excision repair [GO:0006284]; DNA double-strand break processing [GO:0000729]; DNA replication checkpoint signaling [GO:0000076]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication, removal of RNA primer [GO:0043137]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; positive regulation of DNA replication [GO:0045740]; replication fork reversal [GO:0071932]; transmembrane transport [GO:0055085]

chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; gamma DNA polymerase complex [GO:0005760]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]

4 iron, 4 sulfur cluster binding [GO:0051539]; 5'-3' DNA helicase activity [GO:0043139]; 5'-flap endonuclease activity [GO:0017108]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; single-stranded DNA helicase activity [GO:0017116]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.

IPR026851;IPR041679;IPR041677;IPR048459;IPR014808;IPR002167;IPR002067;IPR018108;IPR023395;IPR027417;IPR011604;IPR047187;

3.90.320.10;1.50.40.10;3.40.50.300;

A0A5F7ZFG1

MKCPQSCERMKMSFGLTFKSAKGRWIANPSWQCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMHRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAYGLAPDGDVFLSEEQVRSFQVPSCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSSYRFILTAREKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPR

Macaca mulatta (Rhesus macaque)

FUNCTION: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion. {ECO:0000256|HAMAP-Rule:MF_03161}.

2.3.1.-; 2.3.1.286; 2.4.2.-

CATALYTIC ACTIVITY: Reaction=H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:63640, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10474, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:83099, ChEBI:CHEBI:189572; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; CATALYTIC ACTIVITY: Reaction=H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:70479, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10505, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:83144, ChEBI:CHEBI:189573; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; CATALYTIC ACTIVITY: Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence={ECO:0000256|HAMAP-Rule:MF_03161};

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-Rule:MF_03161};

Metal-binding;Mitochondrion;NAD;Reference proteome;Transferase;Transit peptide;Zinc

DNA damage response [GO:0006974]; glutamine metabolic process [GO:0006541]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of insulin secretion [GO:0046676]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of glutamine family amino acid metabolic process [GO:0000820]; tricarboxylic acid metabolic process [GO:0072350]

mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]

histone deacetylase activity [GO:0004407]; lipoamidase activity [GO:0061690]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD+- protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD-dependent protein biotinidase activity [GO:0106420]; NAD-dependent protein deacetylase activity [GO:0034979]; NAD-dependent protein lipoamidase activity [GO:0106419]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000256|HAMAP-Rule:MF_03161}.

IPR029035;IPR003000;IPR026591;IPR026587;IPR026590;

3.30.1600.10;3.40.50.1220;

A0A5F7ZFY5

MVFCLALAWTLLVGAWTPMGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQALGEPHLPNPRDLSNTISRGPAGLASLRNRTVLAVFFGYHLLSDLVSVETPGCPAEFLNIHIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPQDSQKHLLMWAAPDPATGQSGPRGLYAFGAERGNREPFLQALGLLWFRYHNLCAQRLARQHPDWGDEELFQHARKRVIATYQNIAVYEWLPSFLQKTPPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQVVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVVVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYNKARAALGLSPITRWQDINPVLFRSNDTVLEATADLYKQDLSWLELLPGGLLESHRDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLRDVLVAVINIDPGALQPSVFVWHKGDPCPQPRQLSTEGLPACAPSIVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGRKEPCRPVLVHLQPGQIRVVDGRLTMLRTIQLQPPQQVNLVLSSNRGRRTLLLKIPKEYDLVLLFNSEEERQTLVENLRAALKESGLSIQEWELREQELMRGAVTREQRSHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVQEALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQETICPSPRVSAHCSHGDIETELTPQRLQCPTDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVVLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVCCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFESFFNSLQEVHPQVSPIHIQVHFLFIIWGLSKAPKPAPSRKKLTADENPSPGRLVG

Macaca mulatta (Rhesus macaque)

FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000256|ARBA:ARBA00003796}.

1.6.3.1

CATALYTIC ACTIVITY: Reaction=H(+) + NADH + O2 = H2O2 + NAD(+); Xref=Rhea:RHEA:11264, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.3.1; Evidence={ECO:0000256|ARBA:ARBA00000518}; CATALYTIC ACTIVITY: Reaction=H(+) + NADPH + O2 = H2O2 + NADP(+); Xref=Rhea:RHEA:11260, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.3.1; Evidence={ECO:0000256|ARBA:ARBA00000547};

PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis. {ECO:0000256|ARBA:ARBA00005197}.

Calcium;Cell membrane;FAD;Flavoprotein;Glycoprotein;Membrane;Metal-binding;NADP;Oxidoreductase;Reference proteome;Repeat;Signal;Thyroid hormones biosynthesis;Transmembrane;Transmembrane helix

cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590]

apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]

calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]

SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR034821;IPR011992;IPR018247;IPR002048;IPR013112;IPR017927;IPR013130;IPR013121;IPR039261;IPR019791;IPR010255;IPR037120;IPR017938;

1.10.238.10;1.10.640.10;3.40.50.80;2.40.30.10;

A0A5F7ZGX4

MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEATRAPGVSAARGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHSYIFGFYKWDHEPAKSQATAQLQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGKFRAVSPLLSSKGKFSFTINESTIIDSPRFPHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSIAFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMKQKGFGKDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKVKLAPGTIVEVWKDNAYPEELSKVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTREQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDGAYDRLTRHRCRMVERGIAAQPLYAGYCNHENV

Macaca mulatta (Rhesus macaque)

3.2.1.52

CATALYTIC ACTIVITY: Reaction=H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine; Xref=Rhea:RHEA:64384, ChEBI:CHEBI:15377, ChEBI:CHEBI:152567, ChEBI:CHEBI:152568, ChEBI:CHEBI:153064; Evidence={ECO:0000256|ARBA:ARBA00023541}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64385; Evidence={ECO:0000256|ARBA:ARBA00023541}; CATALYTIC ACTIVITY: Reaction=H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:48276, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:90163, ChEBI:CHEBI:90164; Evidence={ECO:0000256|ARBA:ARBA00023953}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48277; Evidence={ECO:0000256|ARBA:ARBA00023953}; CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; Evidence={ECO:0000256|ARBA:ARBA00001231, ECO:0000256|PIRNR:PIRNR001093}; CATALYTIC ACTIVITY: Reaction=a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:47940, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:60065, ChEBI:CHEBI:71502; Evidence={ECO:0000256|ARBA:ARBA00043767}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47941; Evidence={ECO:0000256|ARBA:ARBA00043767}; CATALYTIC ACTIVITY: Reaction=a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine; Xref=Rhea:RHEA:47968, ChEBI:CHEBI:15377, ChEBI:CHEBI:28497, ChEBI:CHEBI:79210, ChEBI:CHEBI:79218; Evidence={ECO:0000256|ARBA:ARBA00043827}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47969; Evidence={ECO:0000256|ARBA:ARBA00043827}; CATALYTIC ACTIVITY: Reaction=beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine; Xref=Rhea:RHEA:64372, ChEBI:CHEBI:15377, ChEBI:CHEBI:28037, ChEBI:CHEBI:152565, ChEBI:CHEBI:152566; Evidence={ECO:0000256|ARBA:ARBA00023505}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64373; Evidence={ECO:0000256|ARBA:ARBA00023505};

Disulfide bond;Glycosidase;Hydrolase;Lysosome;Reference proteome

astrocyte cell migration [GO:0043615]; chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; intracellular calcium ion homeostasis [GO:0006874]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maintenance of location in cell [GO:0051651]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; neuron cellular homeostasis [GO:0070050]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]

acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]

acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylhexosaminidase activity [GO:0004563]; identical protein binding [GO:0042802]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]

SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000256|ARBA:ARBA00037865}. Lysosome {ECO:0000256|ARBA:ARBA00004371}.

IPR025705;IPR015883;IPR017853;IPR029018;IPR029019;

3.30.379.10;3.20.20.80;

A0A5F7ZHX3

MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAVGAGALALQEPGLWLGEVELAVEKAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKRELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWFQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL

Macaca mulatta (Rhesus macaque)

3.1.3.48

Carbohydrate metabolism;Hydrolase;Protein phosphatase;Reference proteome

autophagosome assembly [GO:0000045]; calcium ion transport [GO:0006816]; carbohydrate phosphorylation [GO:0046835]; dephosphorylation [GO:0016311]; glial cell proliferation [GO:0014009]; glycogen biosynthetic process [GO:0005978]; habituation [GO:0046959]; L-glutamate transmembrane transport [GO:0015813]; mitochondrion organization [GO:0007005]; negative regulation of cell cycle [GO:0045786]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of macroautophagy [GO:0016239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell growth [GO:0001558]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein import into nucleus [GO:0042306]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein ubiquitination [GO:0031396]; Wnt signaling pathway [GO:0016055]

cytoplasm [GO:0005737]; cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]

carbohydrate phosphatase activity [GO:0019203]; glycogen (starch) synthase activity [GO:0004373]; glycogen binding [GO:2001069]; protein homodimerization activity [GO:0042803]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; starch binding [GO:2001070]

IPR013784;IPR034831;IPR002044;IPR045204;IPR000340;IPR013783;IPR042942;IPR029021;IPR016130;IPR000387;IPR020422;

2.60.40.10;3.90.190.10;

A0A5F7ZIA6

MAESPASAFRDSLRKSVRTAAGNPGVPELGGTHPGLREEREKVKLGVATPRLVGMQLEGASWERACSQSQEEEEVEEEGCLRKYKNEVVELRFPSIGTGETRGAAWAAVRPFPRGSFRRRAPGPHPSPHPAPHALPAGSSRSHGAGAAVSTMELAAWYRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDLLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPVCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLRVFETLEEITGYLYISAWPDSLPDLSVLQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTRLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQSCPINCTHSPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGTGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPRAPSEGTGSDVFDGDLGMGAAKGLQSLPAHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPGMESSLSGETDGRGRGDPQPRVHCGGRGSGSDTGVPSPNRSSSLGLSEYVNQPDVRPQPPSPQEGPLSPARPTGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRGGAAPQPHLPPAFSPAFDNLYYWDQDPSERGAPPSTFKGTPTAENPEYLGLDVPV

Macaca mulatta (Rhesus macaque)

FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000256|ARBA:ARBA00037619}.

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Cytoplasm;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Transcription;Transcription regulation;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

cellular response to epidermal growth factor stimulus [GO:0071364]; ERBB2-EGFR signaling pathway [GO:0038134]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERBB2-ERBB4 signaling pathway [GO:0038135]; heart development [GO:0007507]; immature T cell proliferation in thymus [GO:0033080]; motor neuron axon guidance [GO:0008045]; myelination [GO:0042552]; negative regulation of apoptotic process [GO:0043066]; negative regulation of immature T cell proliferation in thymus [GO:0033088]; neurogenesis [GO:0022008]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; oligodendrocyte differentiation [GO:0048709]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of translation [GO:0045727]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of microtubule-based process [GO:0032886]; Schwann cell development [GO:0014044]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing [GO:0042060]

apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ERBB3:ERBB2 complex [GO:0038143]; myelin sheath [GO:0043209]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]; ruffle membrane [GO:0032587]; semaphorin receptor complex [GO:0002116]

ATP binding [GO:0005524]; coreceptor activity [GO:0015026]; ErbB-3 class receptor binding [GO:0043125]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase I core binding [GO:0001042]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]

SUBCELLULAR LOCATION: Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004199}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004199}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR044912;IPR006211;IPR006212;IPR032778;IPR009030;IPR011009;IPR000719;IPR017441;IPR000494;IPR036941;IPR001245;IPR049328;IPR008266;IPR020635;IPR016245;

6.10.250.2930;3.80.20.20;1.10.510.10;

A0A5F7ZJ41

MAQRCLCVLALAAMLLLVFATVSRSMGLRSDEHQRESRIPAEFSKEERVAMKEALKGAIQIPTVTFSYEKANTTALVEFGKYIYKVFPTVLSTSFIQHEVVEEYSHLFTIKGSDPSLQPYLLMAHFDVVPAPEEGWEVPPFSGLEREGAIYGRGTLDDKNSVMALLQALELLLIRKYIPRRSFFISLGHDEESSGTGAQKVSALLQSRGVQLAFVVDEGGFILDDFIPDFKKPIALIGVSEKGSMNLLLQVNMSSGHSSAPPKETSIGILAAAVSRLEQTPMPIIFGSGTLVTVLRQMADEFPFPVDKILSNPRLFEPLITRFMEKNPLTNAMIRTTTALTIFEAGIKVNVIPSVAKAAVNFRIHSGQTVQEVLELTKNIVADNRVQFHVMTAFDPLPISPYDDKALGYQLLRQTIQSVFPEVNITIPGTCLGNTDSRFFTDLTTGIYRFNPYYLQPEDLKRVSSSPPRIDGNWPLFYKDGDNWVIGEKLVESVPLGANPSSSCLWERAYPLDPVSSTYKMGRLLSIL

Macaca mulatta (Rhesus macaque)

CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine; Xref=Rhea:RHEA:51312, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:58095, ChEBI:CHEBI:134022; Evidence={ECO:0000256|ARBA:ARBA00034626}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51313; Evidence={ECO:0000256|ARBA:ARBA00034626}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51314; Evidence={ECO:0000256|ARBA:ARBA00034626}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine; Xref=Rhea:RHEA:51300, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58095, ChEBI:CHEBI:134020; Evidence={ECO:0000256|ARBA:ARBA00034630}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51301; Evidence={ECO:0000256|ARBA:ARBA00034630}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51302; Evidence={ECO:0000256|ARBA:ARBA00034630}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine; Xref=Rhea:RHEA:51316, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57305, ChEBI:CHEBI:133992; Evidence={ECO:0000256|ARBA:ARBA00034640}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51318; Evidence={ECO:0000256|ARBA:ARBA00034640}; CATALYTIC ACTIVITY: Reaction=H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine; Xref=Rhea:RHEA:64132, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:77016, ChEBI:CHEBI:149701; Evidence={ECO:0000256|ARBA:ARBA00034635}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64133; Evidence={ECO:0000256|ARBA:ARBA00034635}; CATALYTIC ACTIVITY: Reaction=H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine; Xref=Rhea:RHEA:64108, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57305, ChEBI:CHEBI:59002; Evidence={ECO:0000256|ARBA:ARBA00034637}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64109; Evidence={ECO:0000256|ARBA:ARBA00034637}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64110; Evidence={ECO:0000256|ARBA:ARBA00034637}; CATALYTIC ACTIVITY: Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine; Xref=Rhea:RHEA:64116, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:33384, ChEBI:CHEBI:149697; Evidence={ECO:0000256|ARBA:ARBA00034616}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64117; Evidence={ECO:0000256|ARBA:ARBA00034616}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64118; Evidence={ECO:0000256|ARBA:ARBA00034616}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-asparagine = (9Z)-octadecenoate + L-asparagine; Xref=Rhea:RHEA:64136, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58048, ChEBI:CHEBI:149730; Evidence={ECO:0000256|ARBA:ARBA00034627}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64137; Evidence={ECO:0000256|ARBA:ARBA00034627}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine; Xref=Rhea:RHEA:51356, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58359, ChEBI:CHEBI:134033; Evidence={ECO:0000256|ARBA:ARBA00034643}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51357; Evidence={ECO:0000256|ARBA:ARBA00034643}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine; Xref=Rhea:RHEA:51360, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57427, ChEBI:CHEBI:134035; Evidence={ECO:0000256|ARBA:ARBA00034652}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51361; Evidence={ECO:0000256|ARBA:ARBA00034652}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:51362; Evidence={ECO:0000256|ARBA:ARBA00034652}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine; Xref=Rhea:RHEA:64192, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:32551, ChEBI:CHEBI:149731; Evidence={ECO:0000256|ARBA:ARBA00034633}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64193; Evidence={ECO:0000256|ARBA:ARBA00034633}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine; Xref=Rhea:RHEA:64144, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57844, ChEBI:CHEBI:149732; Evidence={ECO:0000256|ARBA:ARBA00034645}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64145; Evidence={ECO:0000256|ARBA:ARBA00034645}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine; Xref=Rhea:RHEA:51352, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:33384, ChEBI:CHEBI:134031; Evidence={ECO:0000256|ARBA:ARBA00034646}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51353; Evidence={ECO:0000256|ARBA:ARBA00034646}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan; Xref=Rhea:RHEA:64176, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57912, ChEBI:CHEBI:149733; Evidence={ECO:0000256|ARBA:ARBA00034619}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64177; Evidence={ECO:0000256|ARBA:ARBA00034619}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine; Xref=Rhea:RHEA:64184, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:58315, ChEBI:CHEBI:149734; Evidence={ECO:0000256|ARBA:ARBA00034625}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64185; Evidence={ECO:0000256|ARBA:ARBA00034625}; CATALYTIC ACTIVITY: Reaction=H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine; Xref=Rhea:RHEA:64124, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:58095, ChEBI:CHEBI:149699; Evidence={ECO:0000256|ARBA:ARBA00034620}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64125; Evidence={ECO:0000256|ARBA:ARBA00034620}; CATALYTIC ACTIVITY: Reaction=H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate; Xref=Rhea:RHEA:64128, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:58095, ChEBI:CHEBI:149700; Evidence={ECO:0000256|ARBA:ARBA00034641}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64129; Evidence={ECO:0000256|ARBA:ARBA00034641}; CATALYTIC ACTIVITY: Reaction=an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid; Xref=Rhea:RHEA:15565, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:59869, ChEBI:CHEBI:59874; EC=3.5.1.14; Evidence={ECO:0000256|ARBA:ARBA00034644}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15566; Evidence={ECO:0000256|ARBA:ARBA00034644}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:15567; Evidence={ECO:0000256|ARBA:ARBA00034644}; CATALYTIC ACTIVITY: Reaction=an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid; Xref=Rhea:RHEA:54184, ChEBI:CHEBI:15377, ChEBI:CHEBI:29067, ChEBI:CHEBI:84824, ChEBI:CHEBI:138093; EC=3.5.1.114; Evidence={ECO:0000256|ARBA:ARBA00034622}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54185; Evidence={ECO:0000256|ARBA:ARBA00034622}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:54186; Evidence={ECO:0000256|ARBA:ARBA00034622};

PATHWAY: Amino-acid metabolism. {ECO:0000256|ARBA:ARBA00034698}.; PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000256|ARBA:ARBA00004872}.

Hydrolase;Metal-binding;Protease;Reference proteome;Signal;Zinc

adaptive thermogenesis [GO:1990845]; amide biosynthetic process [GO:0043604]; amide catabolic process [GO:0043605]; amino acid metabolic process [GO:0006520]; cellular lipid metabolic process [GO:0044255]; energy homeostasis [GO:0097009]; proteolysis involved in protein catabolic process [GO:0051603]

extracellular space [GO:0005615]

carboxypeptidase activity [GO:0004180]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; metal ion binding [GO:0046872]

IPR036264;IPR047177;IPR002933;IPR011650;

3.30.70.360;3.40.630.10;

A0A5F7ZJF7

MGPLPVCLPIMLLLLLPSLLLLLPGPGPRSGEASRTLHMQRRGILELAGTVGCVGSRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHRHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCERDSPKCG

Macaca mulatta (Rhesus macaque)

3.1.1.4

CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000256|RuleBase:RU361236};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR601211-2}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR601211-2};

Calcium;Disulfide bond;Hydrolase;Lipid metabolism;Metal-binding;Reference proteome;Secreted;Signal

arachidonic acid secretion [GO:0050482]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; defense response to virus [GO:0051607]; erythrocyte maturation [GO:0043249]; fertilization [GO:0009566]; hair follicle morphogenesis [GO:0031069]; intestinal stem cell homeostasis [GO:0036335]; low-density lipoprotein particle remodeling [GO:0034374]; lysophospholipid transport [GO:0051977]; macrophage activation [GO:0042116]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; platelet activating factor catabolic process [GO:0062234]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of lipid storage [GO:0010884]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of protein metabolic process [GO:0051247]; production of molecular mediator involved in inflammatory response [GO:0002532]; prostaglandin biosynthetic process [GO:0001516]; regulation of macrophage activation [GO:0043030]

acrosomal vesicle [GO:0001669]; extracellular space [GO:0005615]

1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipid binding [GO:0005543]

SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU361236}.

IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;

1.20.90.10;

A0A5F7ZL92

MPDRGKGDMCLVEKRRWEGRNGADDQDGKRDLQTPREPTTCSFTALQEIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTNDIDKAVTISSALQAGTVWVNCYGVVTAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS

Macaca mulatta (Rhesus macaque)

1.2.1.19; 1.2.1.28; 1.2.1.3; 1.2.1.36

CATALYTIC ACTIVITY: Reaction=(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58968, ChEBI:CHEBI:142920; Evidence={ECO:0000256|ARBA:ARBA00036562}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67249; Evidence={ECO:0000256|ARBA:ARBA00036562}; CATALYTIC ACTIVITY: Reaction=13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:45487, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:169952; Evidence={ECO:0000256|ARBA:ARBA00036540}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67333; Evidence={ECO:0000256|ARBA:ARBA00036540}; CATALYTIC ACTIVITY: Reaction=3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH; Xref=Rhea:RHEA:67244, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57990, ChEBI:CHEBI:60777; Evidence={ECO:0000256|ARBA:ARBA00036972}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67245; Evidence={ECO:0000256|ARBA:ARBA00036972}; CATALYTIC ACTIVITY: Reaction=4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:19105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58264, ChEBI:CHEBI:59888; EC=1.2.1.19; Evidence={ECO:0000256|ARBA:ARBA00036645}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19106; Evidence={ECO:0000256|ARBA:ARBA00036645}; CATALYTIC ACTIVITY: Reaction=9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78273, ChEBI:CHEBI:78630; Evidence={ECO:0000256|ARBA:ARBA00036033}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42085; Evidence={ECO:0000256|ARBA:ARBA00036033}; CATALYTIC ACTIVITY: Reaction=H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate; Xref=Rhea:RHEA:67256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17153, ChEBI:CHEBI:17272, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00036694}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67257; Evidence={ECO:0000256|ARBA:ARBA00036694}; CATALYTIC ACTIVITY: Reaction=H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH; Xref=Rhea:RHEA:67276, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:88528; Evidence={ECO:0000256|ARBA:ARBA00036723}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67277; Evidence={ECO:0000256|ARBA:ARBA00036723}; CATALYTIC ACTIVITY: Reaction=H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH; Xref=Rhea:RHEA:67252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33190, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:566274; Evidence={ECO:0000256|ARBA:ARBA00036632}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67253; Evidence={ECO:0000256|ARBA:ARBA00036632}; CATALYTIC ACTIVITY: Reaction=acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH; Xref=Rhea:RHEA:25294, ChEBI:CHEBI:15343, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00036545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25295; Evidence={ECO:0000256|ARBA:ARBA00036545}; CATALYTIC ACTIVITY: Reaction=all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH; Xref=Rhea:RHEA:42080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.36; Evidence={ECO:0000256|ARBA:ARBA00035919}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42081; Evidence={ECO:0000256|ARBA:ARBA00035919}; CATALYTIC ACTIVITY: Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00036925}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16186; Evidence={ECO:0000256|ARBA:ARBA00036925}; CATALYTIC ACTIVITY: Reaction=benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH; Xref=Rhea:RHEA:11840, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:17169, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.28; Evidence={ECO:0000256|ARBA:ARBA00036598}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11841; Evidence={ECO:0000256|ARBA:ARBA00036598};

PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000256|ARBA:ARBA00004891}.

Oxidoreductase;Reference proteome

cellular detoxification of aldehyde [GO:0110095]; fructosamine catabolic process [GO:0030392]

cytosol [GO:0005829]

3-deoxyglucosone dehydrogenase activity [GO:0106373]; benzaldehyde dehydrogenase (NAD+) activity [GO:0018479]

IPR016161;IPR016163;IPR016160;IPR029510;IPR016162;IPR015590;

A0A5F7ZLL7

MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVSTNDDRYCHRHLLPRGLVNLEGSLLSSHGSRRCWWESSSPYASPSGQLPLRTGTQVTWVKSPSCSQLAVTLRHCLGYLNFSSLSAL

Macaca mulatta (Rhesus macaque)

CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000256|ARBA:ARBA00000249}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00000249};

Autophagy;Endosome;GTP-binding;Lipid degradation;Lipid metabolism;Nucleotide-binding;Reference proteome

autophagosome assembly [GO:0000045]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; epidermal growth factor catabolic process [GO:0007174]; establishment of vesicle localization [GO:0051650]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; negative regulation of exosomal secretion [GO:1903542]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; viral release from host cell [GO:0019076]

autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; retromer complex [GO:0030904]

GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]

SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane {ECO:0000256|ARBA:ARBA00037866}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037866}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037866}. Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00037824}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037824}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037824}. Endosome membrane {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004125}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004492}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004630}. Melanosome membrane {ECO:0000256|ARBA:ARBA00037798}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037798}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00037798}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004318}.

IPR027417;IPR005225;IPR001806;

3.40.50.300;

A0A5F7ZLM3

MDTPAWAPPRGHPGHRRADTLTRTPRPRGHLPRGRPDPILPAAPRAAPRTPPATACVRHRKRPPNPRSATAIAAILAGLLGRLGLPAALPAPDRGGSSPGRAAAVEMLEAPPLLLAAVFLGLVLVVLLLILRRWGWGLCLICWNEFVLQPIRNLLMGDTKEQRILHHVLQHAEPGNAQSVVEAIDTYCQQKEWAMNVGDKKGKIVDAVIQEHQPSMLLELGAYCGYSAVRMARLLSPGARLLTIEINPDYAAITQRMVDFAGMQDKVTVVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLTHVRGSNRFECTHYQSFLEYRKVVDGLEKAIYKGPGSEAQP

Macaca mulatta (Rhesus macaque)

2.1.1.6

CATALYTIC ACTIVITY: Reaction=a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17877, ChEBI:CHEBI:15378, ChEBI:CHEBI:33566, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:134251; EC=2.1.1.6; Evidence={ECO:0000256|ARBA:ARBA00001722}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17878; Evidence={ECO:0000256|ARBA:ARBA00001722};

Catecholamine metabolism;Membrane;Methyltransferase;Neurotransmitter degradation;Reference proteome;S-adenosyl-L-methionine;Transferase;Transmembrane;Transmembrane helix

artery development [GO:0060840]; behavioral fear response [GO:0001662]; catecholamine catabolic process [GO:0042424]; cellular response to cocaine [GO:0071314]; cellular response to phosphate starvation [GO:0016036]; cerebellar cortex morphogenesis [GO:0021696]; cholesterol efflux [GO:0033344]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; developmental process [GO:0032502]; dopamine catabolic process [GO:0042420]; dopamine metabolic process [GO:0042417]; dopamine secretion [GO:0014046]; exploration behavior [GO:0035640]; gene expression [GO:0010467]; glomerulus development [GO:0032835]; glycogen metabolic process [GO:0005977]; habituation [GO:0046959]; mastication [GO:0071626]; memory [GO:0007613]; methylation [GO:0032259]; multicellular organism growth [GO:0035264]; norepinephrine metabolic process [GO:0042415]; norepinephrine secretion [GO:0048243]; prostaglandin metabolic process [GO:0006693]; renal albumin absorption [GO:0097018]; renal filtration [GO:0097205]; renal sodium excretion [GO:0035812]; renin secretion into blood stream [GO:0002001]; response to amphetamine [GO:0001975]; response to angiotensin [GO:1990776]; response to corticosterone [GO:0051412]; response to cytokine [GO:0034097]; response to dopamine [GO:1903350]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to oxidative stress [GO:0006979]; response to salt [GO:1902074]; response to toxic substance [GO:0009636]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; startle response [GO:0001964]; synaptic transmission, dopaminergic [GO:0001963]; visual learning [GO:0008542]

axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; synapse [GO:0045202]; vesicle [GO:0031982]

catechol O-methyltransferase activity [GO:0016206]

IPR029063;IPR002935;

3.40.50.150;

A0A5F7ZNA4

MSLFSNNMFLYLKFDVGWASNSIMARGLRPQLHPCEAQILQGTRVPRGMCTLRIVLPGWQRDPSGTMSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRGTVIVPTLDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLLLSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS

Macaca mulatta (Rhesus macaque)

FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. {ECO:0000256|RuleBase:RU368050}.

1.14.13.n7; 1.14.14.1

CATALYTIC ACTIVITY: Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:132025; Evidence={ECO:0000256|ARBA:ARBA00000615, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50089; Evidence={ECO:0000256|ARBA:ARBA00000615, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence={ECO:0000256|ARBA:ARBA00001354, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50077; Evidence={ECO:0000256|ARBA:ARBA00001354, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence={ECO:0000256|ARBA:ARBA00000326, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39788; Evidence={ECO:0000256|ARBA:ARBA00000326, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50096, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30807, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132031; Evidence={ECO:0000256|ARBA:ARBA00000338, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50097; Evidence={ECO:0000256|ARBA:ARBA00000338, ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000256|ARBA:ARBA00000089}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence={ECO:0000256|ARBA:ARBA00000089}; CATALYTIC ACTIVITY: Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; Evidence={ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17150; Evidence={ECO:0000256|RuleBase:RU368050}; CATALYTIC ACTIVITY: Reaction=dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39751, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:18262, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76628; Evidence={ECO:0000256|ARBA:ARBA00001427, ECO:0000256|RuleBase:RU368050}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39752; Evidence={ECO:0000256|ARBA:ARBA00001427, ECO:0000256|RuleBase:RU368050};

COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000256|ARBA:ARBA00001971, ECO:0000256|PIRSR:PIRSR602401-1, ECO:0000256|RuleBase:RU368050};

PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000256|ARBA:ARBA00004872, ECO:0000256|RuleBase:RU368050}.

Endoplasmic reticulum;Fatty acid metabolism;Heme;Iron;Lipid metabolism;Membrane;Metal-binding;Microsome;Mitochondrion;Mitochondrion inner membrane;Monooxygenase;NADP;Oxidoreductase;Reference proteome;Transmembrane;Transmembrane helix

epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]

cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial inner membrane [GO:0005743]

arachidonic acid epoxygenase activity [GO:0008392]; aromatase activity [GO:0070330]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU368050}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368050}. Microsome membrane {ECO:0000256|ARBA:ARBA00004174, ECO:0000256|RuleBase:RU368050}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004174, ECO:0000256|RuleBase:RU368050}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU368050}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368050}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR001128;IPR017972;IPR002401;IPR008070;IPR036396;

1.10.630.10;

A0A5F7ZNR5

RRSLLQRLRSVSQYSEAGPRRGLASHGDEGRESNGPVKVWGSITGLTEGLHGFHVHQFGDNTQGCTSAGPHFNPLSRQHGGPKDEERHVGDLGNVTAGKDGVAKVSFEDSVISLSGDHSIIGRTLVVHEKADDLGKGGNEESKKTGNAGGRLACGVIGIAQ

Macaca mulatta (Rhesus macaque)

FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000256|ARBA:ARBA00003917, ECO:0000256|RuleBase:RU000393}.

1.15.1.1

CATALYTIC ACTIVITY: Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; Evidence={ECO:0000256|RuleBase:RU000393};

COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000256|RuleBase:RU000393}; Note=Binds 1 copper ion per subunit. {ECO:0000256|RuleBase:RU000393}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|RuleBase:RU000393}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU000393};

Copper;Lipoprotein;Metal-binding;Oxidoreductase;Palmitate;Reference proteome;Zinc

action potential initiation [GO:0099610]; anterograde axonal transport [GO:0008089]; apoptotic process [GO:0006915]; auditory receptor cell stereocilium organization [GO:0060088]; determination of adult lifespan [GO:0008340]; ectopic germ cell programmed cell death [GO:0035234]; embryo implantation [GO:0007566]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular iron ion homeostasis [GO:0006879]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of developmental process [GO:0051093]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reproductive process [GO:2000242]; neurofilament cytoskeleton organization [GO:0060052]; neuronal action potential [GO:0019228]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of phagocytosis [GO:0050766]; positive regulation of superoxide anion generation [GO:0032930]; regulation of blood pressure [GO:0008217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; relaxation of vascular associated smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to xenobiotic stimulus [GO:0009410]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]

axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]

copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein phosphatase 2B binding [GO:0030346]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]

IPR036423;IPR024134;IPR018152;IPR001424;

2.60.40.200;

A0A5F7ZPS4

MPTTIEREFEELDTQRRWQSLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSSNKIMTEKYNGNRIGLEEEKLTGDRCTGLPSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFVSVILVGAFVGWTLFFQQNAL

Macaca mulatta (Rhesus macaque)

3.1.3.48

CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000256|PIRNR:PIRNR000926};

Endoplasmic reticulum;Hydrolase;Membrane;Protein phosphatase;Reference proteome;Transmembrane;Transmembrane helix

B cell differentiation [GO:0030183]; dephosphorylation [GO:0016311]; erythrocyte differentiation [GO:0030218]; glucose homeostasis [GO:0042593]; insulin receptor recycling [GO:0038020]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of interleukin-2-mediated signaling pathway [GO:1902206]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of positive thymic T cell selection [GO:1902233]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; T cell differentiation [GO:0030217]

cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome lumen [GO:0031904]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]

integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; receptor tyrosine kinase binding [GO:0030971]; STAT family protein binding [GO:0097677]; syntaxin binding [GO:0019905]

IPR029021;IPR000242;IPR012265;IPR016130;IPR003595;IPR000387;

3.90.190.10;

A0A5F7ZSW0

MQVDDPNAEPWMVMRMIPAGLTLLVGFNPLVTGFKMEHFDASLSTYFKALLGPRDTRVKGWFLLDNYIPTFICSVIYLLIVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTRTAGESDMKIIRVLWWYYFSKLIEFMDTFFFILRKNNHQITVLHVYHHASMLNIWWFVMNWVPCGHSYFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQLLQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMISLIALFTNFYIQTYNKKGASRRKDHLKDHQNGSVAAVNGHTNSFSPLENNVKPRKLRKD

Macaca mulatta (Rhesus macaque)

FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000256|HAMAP-Rule:MF_03205}.

2.3.1.199

CATALYTIC ACTIVITY: Reaction=(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39679, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:75121, ChEBI:CHEBI:76559; Evidence={ECO:0000256|ARBA:ARBA00001296}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39680; Evidence={ECO:0000256|ARBA:ARBA00001296}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36475, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:57384, ChEBI:CHEBI:73852; Evidence={ECO:0000256|ARBA:ARBA00000904}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36476; Evidence={ECO:0000256|ARBA:ARBA00000904}; CATALYTIC ACTIVITY: Reaction=(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35379, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57363, ChEBI:CHEBI:57384, ChEBI:CHEBI:71481; Evidence={ECO:0000256|ARBA:ARBA00000735}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35380; Evidence={ECO:0000256|ARBA:ARBA00000735}; CATALYTIC ACTIVITY: Reaction=(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:35391, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:71489, ChEBI:CHEBI:71491; Evidence={ECO:0000256|ARBA:ARBA00000337}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35392; Evidence={ECO:0000256|ARBA:ARBA00000337}; CATALYTIC ACTIVITY: Reaction=(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:39675, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:61540, ChEBI:CHEBI:76555; Evidence={ECO:0000256|ARBA:ARBA00001297}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39676; Evidence={ECO:0000256|ARBA:ARBA00001297}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36511, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57387, ChEBI:CHEBI:74011; Evidence={ECO:0000256|ARBA:ARBA00001347}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36512; Evidence={ECO:0000256|ARBA:ARBA00001347}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36503, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57384, ChEBI:CHEBI:74012; Evidence={ECO:0000256|ARBA:ARBA00000592}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36504; Evidence={ECO:0000256|ARBA:ARBA00000592}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:36523, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:74034, ChEBI:CHEBI:74054; Evidence={ECO:0000256|ARBA:ARBA00001158}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36524; Evidence={ECO:0000256|ARBA:ARBA00001158}; CATALYTIC ACTIVITY: Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736; EC=2.3.1.199; Evidence={ECO:0000256|HAMAP-Rule:MF_03205, ECO:0000256|RuleBase:RU361115};

PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000256|HAMAP-Rule:MF_03205}.

Cell projection;Endoplasmic reticulum;Fatty acid biosynthesis;Fatty acid metabolism;Lipid biosynthesis;Lipid metabolism;Membrane;Reference proteome;Transferase;Transmembrane;Transmembrane helix

fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of fatty acid biosynthetic process [GO:0045723]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]

dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]

fatty acid elongase activity [GO:0009922]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|HAMAP-Rule:MF_03205}; Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000256|HAMAP-Rule:MF_03205}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. {ECO:0000256|HAMAP-Rule:MF_03205}.

IPR002076;IPR033677;

A0A5F7ZW22

RLTATSASQVQAIPLLFLSLHIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELSKNPYPKDTSRVHTEKPLLWEERGCLLAPGVRMDLEGWGEGL

Macaca mulatta (Rhesus macaque)

FUNCTION: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. {ECO:0000256|RuleBase:RU363048}.

3.6.4.12

CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000256|ARBA:ARBA00000600}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000256|ARBA:ARBA00000600};

ATP-binding;DNA damage;DNA recombination;DNA repair;Helicase;Hydrolase;Nucleotide-binding;Nucleus;Reference proteome;Transcription;Transcription regulation

box C/D snoRNP assembly [GO:0000492]; cellular response to estradiol stimulus [GO:0071392]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; telomere maintenance [GO:0000723]

centrosome [GO:0005813]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; euchromatin [GO:0000791]; Ino80 complex [GO:0031011]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleosome [GO:0000786]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]

ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; beta-catenin binding [GO:0008013]; DNA helicase activity [GO:0003678]; promoter-enhancer loop anchoring activity [GO:0140585]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription corepressor activity [GO:0003714]

SUBCELLULAR LOCATION: Dynein axonemal particle {ECO:0000256|ARBA:ARBA00024190}. Nucleus {ECO:0000256|RuleBase:RU363048}.

IPR003593;IPR027417;IPR027238;IPR041048;IPR042487;IPR010339;

1.10.8.60;3.40.50.300;2.40.50.360;

A0A5F7ZX99

MWAFGASEVGGTDAGGVLGPGGCRGGGAYGEWEEPRGSGCSGEATLGSALRARWAGRWADGRGSPTGAGGGVPHGVRSAPPHPRPPVLRRGSEEMPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV

Macaca mulatta (Rhesus macaque)

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000946}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569};

ATP-binding;Cytoplasm;Kinase;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Zinc;Zinc-finger

actin filament organization [GO:0007015]; cell-cell junction organization [GO:0045216]; cellular response to insulin stimulus [GO:0032869]; establishment of apical/basal cell polarity [GO:0035089]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; eye photoreceptor cell development [GO:0042462]; intracellular signal transduction [GO:0035556]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron apoptotic process [GO:0043524]; phosphorylation [GO:0016310]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of glucose import [GO:0046326]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of primary metabolic process [GO:0080090]

apical plasma membrane [GO:0016324]; brush border [GO:0005903]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; PAR polarity complex [GO:0120157]; Schmidt-Lanterman incisure [GO:0043220]

ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR000961;IPR034661;IPR046349;IPR020454;IPR011009;IPR034877;IPR000270;IPR002219;IPR017892;IPR000719;IPR017441;IPR008271;

3.30.60.20;1.10.510.10;

A0A5F7ZYF3

MRAPGAGTASVVSLALLWLLGLPWTWSAVAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFVQLDAYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMAAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTQRFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSLLDPNAMYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDQLFFLDLKQGHYLPLNESPGPGLLRLLGSRCCSSM

Macaca mulatta (Rhesus macaque)

6.2.1.3

CATALYTIC ACTIVITY: Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036436}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence={ECO:0000256|ARBA:ARBA00036436}; CATALYTIC ACTIVITY: Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence={ECO:0000256|ARBA:ARBA00024484}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence={ECO:0000256|ARBA:ARBA00024484}; CATALYTIC ACTIVITY: Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036527}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence={ECO:0000256|ARBA:ARBA00036527};

Ligase;Lipid metabolism;Reference proteome

adiponectin-activated signaling pathway [GO:0033211]; biotin import across plasma membrane [GO:1905135]; cardiolipin biosynthetic process [GO:0032049]; export across plasma membrane [GO:0140115]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import across plasma membrane [GO:0015911]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to cold [GO:0009409]

basal plasma membrane [GO:0009925]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]

biotin transmembrane transporter activity [GO:0015225]; efflux transmembrane transporter activity [GO:0015562]; fatty acid transmembrane transporter activity [GO:0015245]; identical protein binding [GO:0042802]; long-chain fatty acid transporter activity [GO:0005324]; nucleotide binding [GO:0000166]; oleoyl-CoA ligase activity [GO:0090434]; protein serine/threonine kinase activator activity [GO:0043539]; very long-chain fatty acid-CoA ligase activity [GO:0031957]

IPR025110;IPR045851;IPR020845;IPR000873;IPR042099;

3.30.300.30;3.40.50.12780;

A0A5F7ZYR0

MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTLMGGLEPRPPRQPATFCACKKRRDASYRCPTRAPCDTGMWLSALYVS

Macaca mulatta (Rhesus macaque)

2.7.12.2

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000256|ARBA:ARBA00036883}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000256|ARBA:ARBA00036524}; CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2; Evidence={ECO:0000256|ARBA:ARBA00035978};

ATP-binding;Coiled coil;Kinase;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; MAPK cascade [GO:0000165]; myelination [GO:0042552]; phosphorylation [GO:0016310]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of stress-activated MAPK cascade [GO:0032872]; Schwann cell development [GO:0014044]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]

cell-cell junction [GO:0005911]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]

ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP-kinase scaffold activity [GO:0005078]; PDZ domain binding [GO:0030165]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; scaffold protein binding [GO:0097110]

IPR011009;IPR000719;IPR017441;IPR008271;

1.10.510.10;

A0A5F8A004

MADVFPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVTLCTKMHWLQWASRSSCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV

Macaca mulatta (Rhesus macaque)

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000946}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569, ECO:0000256|PIRNR:PIRNR000550};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR000550-4}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain. {ECO:0000256|PIRSR:PIRSR000550-4};

Acetylation;ATP-binding;Calcium;Cytoplasm;Kinase;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Repeat;Serine/threonine-protein kinase;Transferase;Zinc;Zinc-finger

desmosome assembly [GO:0002159]; intracellular signal transduction [GO:0035556]; negative regulation of glial cell apoptotic process [GO:0034351]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of angiotensin-activated signaling pathway [GO:0110063]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of mitotic cell cycle [GO:0045931]; post-translational protein modification [GO:0043687]; regulation of platelet aggregation [GO:0090330]; regulation of primary metabolic process [GO:0080090]; response to interleukin-1 [GO:0070555]

ciliary basal body [GO:0036064]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]

ATP binding [GO:0005524]; calcium,diacylglycerol-dependent serine/threonine kinase activity [GO:0004698]; enzyme binding [GO:0019899]; histone H3T6 kinase activity [GO:0035403]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion membrane {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004318}.

IPR000961;IPR046349;IPR000008;IPR035892;IPR034663;IPR020454;IPR011009;IPR002219;IPR017892;IPR000719;IPR017441;IPR014375;IPR008271;

3.30.60.20;2.60.40.150;1.10.510.10;

A0A5F8A113

MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQRSRDMASLRLHAARQGTRCRPQRPRRTY

Macaca mulatta (Rhesus macaque)

2.7.11.1; 2.7.11.26

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001127}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17990; Evidence={ECO:0000256|ARBA:ARBA00001127}; CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]; Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA-COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence={ECO:0000256|ARBA:ARBA00036761}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12802; Evidence={ECO:0000256|ARBA:ARBA00036761}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001416}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46609; Evidence={ECO:0000256|ARBA:ARBA00001416}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L-threonyl-[tau protein]; Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26; Evidence={ECO:0000256|ARBA:ARBA00036446}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53905; Evidence={ECO:0000256|ARBA:ARBA00036446};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase;Wnt signaling pathway

endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; non-motile cilium assembly [GO:1905515]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; regulation of circadian rhythm [GO:0042752]; signal transduction [GO:0007165]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]

centrosome [GO:0005813]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle microtubule [GO:0005876]

ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR011009;IPR000719;IPR017441;IPR008271;

1.10.510.10;

A0A5F8A1T8

MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQHAFHIMIEDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL

Macaca mulatta (Rhesus macaque)

2.7.11.30

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]; Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00036790}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18674; Evidence={ECO:0000256|ARBA:ARBA00036790}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]; Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30; Evidence={ECO:0000256|ARBA:ARBA00036287}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44881; Evidence={ECO:0000256|ARBA:ARBA00036287};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU361271}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|RuleBase:RU361271};

ATP-binding;Cell membrane;Kinase;Magnesium;Manganese;Membrane;Metal-binding;Nucleotide-binding;Receptor;Reference proteome;Serine/threonine-protein kinase;Signal;Transferase;Transmembrane;Transmembrane helix

activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; cellular response to growth factor stimulus [GO:0071363]; determination of left/right symmetry [GO:0007368]; embryonic skeletal system development [GO:0048706]; gastrulation with mouth forming second [GO:0001702]; mesoderm development [GO:0007498]; odontogenesis of dentin-containing tooth [GO:0042475]; penile erection [GO:0043084]; phosphorylation [GO:0016310]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of nitric oxide biosynthetic process [GO:0045428]; Sertoli cell proliferation [GO:0060011]; sperm ejaculation [GO:0042713]; spermatogenesis [GO:0007283]

activin receptor complex [GO:0048179]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]

activin binding [GO:0048185]; activin receptor activity [GO:0017002]; ATP binding [GO:0005524]; BMP receptor activity [GO:0098821]; coreceptor activity [GO:0015026]; growth factor binding [GO:0019838]; inhibin binding [GO:0034711]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein self-association [GO:0043621]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU361271}.

IPR000472;IPR011009;IPR000719;IPR008271;IPR045860;IPR000333;

2.10.60.10;1.10.510.10;

A0A5F8A1X8

MDESALTLGTIDVSYLPNSSEYSVGRCKHTSEEWGECGFRPTVFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWDRFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLHIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIEGHYNGEQLGKPKKNESLWSIARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSAPLSLEQALLPAILPSRPNDAADEGRDTSINESRNATDEFLRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRNDEFFITPSTTVPAVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLGGPTGTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEHDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLVTRTERNVAVYEHRFCGFFESSQIRPDIQSVPSGNSGKRVPADDVHVLWMHDAAVKLTDAQDHPIRSPASLSP

Macaca mulatta (Rhesus macaque)

FUNCTION: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids. {ECO:0000256|ARBA:ARBA00023435}.

2.3.1.15

CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37199, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57597, ChEBI:CHEBI:74544; Evidence={ECO:0000256|ARBA:ARBA00023362}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37200; Evidence={ECO:0000256|ARBA:ARBA00023362}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37203, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:57597, ChEBI:CHEBI:74547; Evidence={ECO:0000256|ARBA:ARBA00023344}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37204; Evidence={ECO:0000256|ARBA:ARBA00023344}; CATALYTIC ACTIVITY: Reaction=1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA; Xref=Rhea:RHEA:33203, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64716, ChEBI:CHEBI:64840; Evidence={ECO:0000256|ARBA:ARBA00023355}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33204; Evidence={ECO:0000256|ARBA:ARBA00023355}; CATALYTIC ACTIVITY: Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; Evidence={ECO:0000256|PIRNR:PIRNR000437}; CATALYTIC ACTIVITY: Reaction=dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA; Xref=Rhea:RHEA:35727, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57597, ChEBI:CHEBI:72682; Evidence={ECO:0000256|ARBA:ARBA00023335}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35728; Evidence={ECO:0000256|ARBA:ARBA00023335}; CATALYTIC ACTIVITY: Reaction=hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:35723, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57518, ChEBI:CHEBI:57597; Evidence={ECO:0000256|ARBA:ARBA00023405}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35724; Evidence={ECO:0000256|ARBA:ARBA00023405}; CATALYTIC ACTIVITY: Reaction=octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA; Xref=Rhea:RHEA:37195, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57597, ChEBI:CHEBI:74565; Evidence={ECO:0000256|ARBA:ARBA00023374}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37196; Evidence={ECO:0000256|ARBA:ARBA00023374};

PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.; PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. {ECO:0000256|ARBA:ARBA00004765, ECO:0000256|PIRNR:PIRNR000437}.

Acetylation;Acyltransferase;Lipid biosynthesis;Lipid metabolism;Membrane;Mitochondrion;Phospholipid biosynthesis;Phospholipid metabolism;Phosphoprotein;Reference proteome;Transferase;Transmembrane;Transmembrane helix

activated T cell proliferation [GO:0050798]; activation-induced cell death of T cells [GO:0006924]; acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; defense response to virus [GO:0051607]; fatty acid homeostasis [GO:0055089]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; negative regulation of activation-induced cell death of T cells [GO:0070236]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid biosynthetic process [GO:0008654]; phospholipid homeostasis [GO:0055091]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of multicellular organism growth [GO:0040018]; regulation of cytokine production [GO:0001817]; response to glucose [GO:0009749]; triglyceride biosynthetic process [GO:0019432]

mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]

glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004374}.

IPR022284;IPR045520;IPR041728;IPR028354;IPR002123;

A0A5F8A4A6

MPPGLCVTHTHAHTALARFPPSFPAPGRIPHLFQLSTEGKRERECVGSASKEGRGKRNKATDDATSDSCIPKEAPDQPKQKMGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNILQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQCVEDATGKLKLHKCKGPVQLGSSRALSNLVPKYYGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYARSRSIRSVAIEVDGRVYHVGLGDAAQPRNLTKRHWPGAPEDQDDKDGGDFSGTGGLPDYSAANPIKVTHRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHKGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG

Macaca mulatta (Rhesus macaque)

FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. {ECO:0000256|PIRNR:PIRNR036665}.

3.1.6.-

CATALYTIC ACTIVITY: Reaction=Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.; EC=3.1.6.14; Evidence={ECO:0000256|ARBA:ARBA00034997}; CATALYTIC ACTIVITY: Reaction=an aryl sulfate + H2O = a phenol + H(+) + sulfate; Xref=Rhea:RHEA:17261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:33853, ChEBI:CHEBI:140317; EC=3.1.6.1; Evidence={ECO:0000256|ARBA:ARBA00034984};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|PIRSR:PIRSR036665-52}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR036665-52};

Calcium;Coiled coil;Endoplasmic reticulum;Golgi apparatus;Hydrolase;Metal-binding;Reference proteome;Signal

bone development [GO:0060348]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]

cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]

arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]

SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR036665}. Golgi apparatus, Golgi stack {ECO:0000256|ARBA:ARBA00004348, ECO:0000256|PIRNR:PIRNR036665}. Cell surface {ECO:0000256|PIRNR:PIRNR036665}.

PTM: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000256|PIRSR:PIRSR036665-50}.

IPR017850;IPR014615;IPR024609;IPR024607;IPR000917;

3.40.720.10;

A0A5F8A4B4

MFSSLLFSPEKNHTIIPNPFDKVSVIWTRPILRKGYRQRLELSDIYQIPSADSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIVPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKINERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIVLRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNSNRKTSNDDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLRPDFSSKLMGYDSFDQFSAERRNSILTETLRRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEVILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQSIHRKTAASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWFLGNTPPQDKGNSTYSRNNSYAVIITRTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEEGKPTRSTKPYKNGQLSKVMVIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNPILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKTQPQIAALKEETEEEVQDTRL

Macaca mulatta (Rhesus macaque)

FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. {ECO:0000256|ARBA:ARBA00033719}.; FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. {ECO:0000256|RuleBase:RU362037}.

5.6.1.6

CATALYTIC ACTIVITY: Reaction=ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.; EC=5.6.1.6; Evidence={ECO:0000256|ARBA:ARBA00034073, ECO:0000256|RuleBase:RU362037};

ATP-binding;Chloride;Chloride channel;Endoplasmic reticulum;Endosome;Glycoprotein;Ion channel;Ion transport;Isomerase;Isopeptide bond;Lipoprotein;Membrane;Nucleotide-binding;Nucleus;Palmitate;Phosphoprotein;Reference proteome;Repeat;Transmembrane;Transmembrane helix;Transport;Ubl conjugation

amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; chloride transmembrane transport [GO:1902476]; cholesterol biosynthetic process [GO:0006695]; cholesterol transport [GO:0030301]; establishment of localization in cell [GO:0051649]; intracellular pH elevation [GO:0051454]; membrane hyperpolarization [GO:0060081]; multicellular organismal-level water homeostasis [GO:0050891]; positive regulation of enamel mineralization [GO:0070175]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to endoplasmic reticulum stress [GO:0034976]; sperm capacitation [GO:0048240]; transepithelial water transport [GO:0035377]; vesicle docking involved in exocytosis [GO:0006904]

apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]

ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel inhibitor activity [GO:0019869]; enzyme binding [GO:0019899]; intracellularly ATP-gated chloride channel activity [GO:0005260]; isomerase activity [GO:0016853]; PDZ domain binding [GO:0030165]; protein-folding chaperone binding [GO:0051087]; Sec61 translocon complex binding [GO:0106138]

SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362037}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362037}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004520}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Endosome membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004337}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Recycling endosome membrane {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004195}.

IPR003593;IPR011527;IPR036640;IPR003439;IPR017871;IPR009147;IPR047082;IPR025837;IPR027417;

1.20.1560.10;3.40.50.300;

A0A5F8A505

MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISASNVVQMKLTPRQTALAPLIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSEDASFTCILKDGIYSSAVVDSELNAVNDGNLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGSYTNSVISDSSSYTLPPSDDTFLGGNLPSDSTSSGIVPNRNTTPCEIFSRSTSTDPFVQDDLEHGLEIMKLPVSRNTKIPLKRCSSLVIFPRSPSNTPPTSPTSPCTLLSKGSYQTSHQFIISPSEIAHNEGGTGAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNTPKQTVCEKSSEGYSCVSVHFTQQKTTTLDCETTNGDCKPEMSEIKLNSDSEYIKLTHRTYACLPSSQNVDYQININGELERPNSQMNKNHGILQRSISLGGAYPNISCLSSLKHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSATSQSASSSNHSSRRGSLQAYTFEEQPALPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSSQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSSDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD

Macaca mulatta (Rhesus macaque)

2.3.2.26

CATALYTIC ACTIVITY: Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};

PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906}.

Reference proteome;Ubl conjugation pathway

cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; formation of structure involved in a symbiotic process [GO:0044111]; glucocorticoid receptor signaling pathway [GO:0042921]; innate immune response [GO:0045087]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein polyubiquitination [GO:0000209]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of synapse organization [GO:0050807]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]

cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]

beta-2 adrenergic receptor binding [GO:0031698]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]

IPR035892;IPR000569;IPR035983;IPR001202;IPR036020;

2.20.70.10;2.60.40.150;3.30.2160.10;3.30.2410.10;3.90.1750.10;

A0A5F8A8E7

MRFAWTVFLLGPLQLCALVRCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAASASAQQPRTPILLIRDNRTAAARARTAGSSGVTAGRPRPTARHWFQAGYSTSGAREAGAPRAENQTAPGDVPELSNLQLPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

Macaca mulatta (Rhesus macaque)

FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). {ECO:0000256|RuleBase:RU367046}.

1.4.3.13

CATALYTIC ACTIVITY: Reaction=H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+); Xref=Rhea:RHEA:24544, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:12448, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:29969, ChEBI:CHEBI:131803; EC=1.4.3.13; Evidence={ECO:0000256|ARBA:ARBA00036237, ECO:0000256|RuleBase:RU367046};

COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000256|ARBA:ARBA00001935, ECO:0000256|RuleBase:RU367046};

Copper;Disulfide bond;LTQ;Metal-binding;Oxidoreductase;Reference proteome;Secreted;Signal;Sulfation;TPQ

ascending aorta development [GO:0035905]; blood vessel morphogenesis [GO:0048514]; bone mineralization [GO:0030282]; cell chemotaxis [GO:0060326]; cellular response to chemokine [GO:1990869]; collagen fibril organization [GO:0030199]; connective tissue development [GO:0061448]; descending aorta development [GO:0035906]; DNA biosynthetic process [GO:0071897]; elastic fiber assembly [GO:0048251]; heart development [GO:0007507]; lung development [GO:0030324]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; osteoblast differentiation [GO:0001649]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; regulation of apoptotic process [GO:0042981]; regulation of bone development [GO:1903010]; regulation of gene expression [GO:0010468]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586]; regulation of protein phosphorylation [GO:0001932]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]

collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]

collagen binding [GO:0005518]; copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; protein-lysine 6-oxidase activity [GO:0004720]

SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000256|ARBA:ARBA00004239, ECO:0000256|RuleBase:RU367046}.

PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000256|RuleBase:RU367046}.

IPR001695;IPR019828;

A0A5F8A945

MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPSIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNTTTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW

Macaca mulatta (Rhesus macaque)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775, ECO:0000256|RuleBase:RU364109};

ATP-binding;Kinase;Nucleotide-binding;Reference proteome;Repeat;Serine/threonine-protein kinase;Transferase

'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; behavioral response to pain [GO:0048266]; calcineurin-NFAT signaling cascade [GO:0033173]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to nutrient [GO:0031670]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; multicellular organism growth [GO:0035264]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of protein localization to nucleus [GO:1900181]; neuronal action potential [GO:0019228]; nucleus localization [GO:0051647]; oligodendrocyte differentiation [GO:0048709]; phosphorylation [GO:0016310]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translational initiation [GO:0045948]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein destabilization [GO:0031648]; regulation of autophagosome assembly [GO:2000785]; regulation of cell growth [GO:0001558]; regulation of cellular response to stress [GO:0080135]; regulation of locomotor rhythm [GO:1904059]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; response to heat [GO:0009408]; ruffle organization [GO:0031529]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; voluntary musculoskeletal movement [GO:0050882]

cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; PML body [GO:0016605]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156]

IPR011989;IPR016024;IPR003152;IPR009076;IPR036738;IPR011009;IPR024585;IPR000403;IPR036940;IPR018936;IPR003151;IPR014009;IPR026683;IPR011990;

1.20.120.150;1.25.10.10;1.10.1070.11;1.25.40.10;

A0A5F8ABT3

MGDRGGAGGSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDMGAAGDAPAPVPSKDADDGVASGHWELRCHRLQDSLFSSDSGFNNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMVHTILFLKLFSYRDVNLWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCMNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSRWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLTLIIGQPIAVLMYVHDYYVLNYEAPVAGA

Macaca mulatta (Rhesus macaque)

CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753; Evidence={ECO:0000256|ARBA:ARBA00000645}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38380; Evidence={ECO:0000256|ARBA:ARBA00000645}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38219, ChEBI:CHEBI:52333, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence={ECO:0000256|ARBA:ARBA00000389}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38220; Evidence={ECO:0000256|ARBA:ARBA00000389}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38435, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75735; Evidence={ECO:0000256|ARBA:ARBA00000883}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38436; Evidence={ECO:0000256|ARBA:ARBA00000883}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:37915, ChEBI:CHEBI:52323, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75342; Evidence={ECO:0000256|ARBA:ARBA00001009}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37916; Evidence={ECO:0000256|ARBA:ARBA00001009}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:55340, ChEBI:CHEBI:34116, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:197429; Evidence={ECO:0000256|ARBA:ARBA00043738}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55341; Evidence={ECO:0000256|ARBA:ARBA00043738}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA; Xref=Rhea:RHEA:55344, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:138735, ChEBI:CHEBI:197429; Evidence={ECO:0000256|ARBA:ARBA00043821}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55345; Evidence={ECO:0000256|ARBA:ARBA00043821}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38307, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75728, ChEBI:CHEBI:75729; Evidence={ECO:0000256|ARBA:ARBA00001100}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38308; Evidence={ECO:0000256|ARBA:ARBA00001100}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA; Xref=Rhea:RHEA:38439, ChEBI:CHEBI:53753, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:75824; Evidence={ECO:0000256|ARBA:ARBA00001338}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38440; Evidence={ECO:0000256|ARBA:ARBA00001338}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:37911, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:73990; Evidence={ECO:0000256|ARBA:ARBA00001793}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37912; Evidence={ECO:0000256|ARBA:ARBA00001793}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA; Xref=Rhea:RHEA:38163, ChEBI:CHEBI:52333, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75583; Evidence={ECO:0000256|ARBA:ARBA00001349}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38164; Evidence={ECO:0000256|ARBA:ARBA00001349}; CATALYTIC ACTIVITY: Reaction=13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:55296, ChEBI:CHEBI:45479, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:138722; Evidence={ECO:0000256|ARBA:ARBA00000895}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55297; Evidence={ECO:0000256|ARBA:ARBA00000895}; CATALYTIC ACTIVITY: Reaction=2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA; Xref=Rhea:RHEA:38071, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:73990, ChEBI:CHEBI:75466; Evidence={ECO:0000256|ARBA:ARBA00001313}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38072; Evidence={ECO:0000256|ARBA:ARBA00001313}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20; Evidence={ECO:0000256|ARBA:ARBA00001150}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10869; Evidence={ECO:0000256|ARBA:ARBA00001150}; CATALYTIC ACTIVITY: Reaction=all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA; Xref=Rhea:RHEA:11488, ChEBI:CHEBI:17336, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342, ChEBI:CHEBI:63410; EC=2.3.1.76; Evidence={ECO:0000256|ARBA:ARBA00000633}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11489; Evidence={ECO:0000256|ARBA:ARBA00000633}; CATALYTIC ACTIVITY: Reaction=all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA; Xref=Rhea:RHEA:38175, ChEBI:CHEBI:17336, ChEBI:CHEBI:17616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence={ECO:0000256|ARBA:ARBA00001764}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38176; Evidence={ECO:0000256|ARBA:ARBA00001764}; CATALYTIC ACTIVITY: Reaction=hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate; Xref=Rhea:RHEA:38167, ChEBI:CHEBI:16125, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75584; Evidence={ECO:0000256|ARBA:ARBA00001796}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38168; Evidence={ECO:0000256|ARBA:ARBA00001796}; CATALYTIC ACTIVITY: Reaction=hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA; Xref=Rhea:RHEA:38211, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75608; Evidence={ECO:0000256|ARBA:ARBA00001118}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38212; Evidence={ECO:0000256|ARBA:ARBA00001118}; CATALYTIC ACTIVITY: Reaction=hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA; Xref=Rhea:RHEA:38171, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:75586, ChEBI:CHEBI:75587; Evidence={ECO:0000256|ARBA:ARBA00000174}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38172; Evidence={ECO:0000256|ARBA:ARBA00000174};

PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000256|ARBA:ARBA00005175}.

Acyltransferase;Endoplasmic reticulum;Membrane;Reference proteome;Transferase;Transmembrane;Transmembrane helix

diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]; very-low-density lipoprotein particle assembly [GO:0034379]

endoplasmic reticulum membrane [GO:0005789]

2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; identical protein binding [GO:0042802]; retinol O-fatty-acyltransferase activity [GO:0050252]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR027251;IPR004299;IPR014371;

A0A5F8ADY8

MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDSQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAVKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVVRDPALHCLWAGLLLPCPPSLLHHSHAFHLSLLPASVLPRSPQHVQSQLLPLYSHPLPPDSVSTHWGLWIPLYAQDPVLGNRVKTSCYYSIQSILQYIWGVPSPC

Macaca mulatta (Rhesus macaque)

2.7.11.13

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000946}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.13; Evidence={ECO:0000256|ARBA:ARBA00000569, ECO:0000256|PIRNR:PIRNR000551};

ATP-binding;Cytoplasm;Kinase;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Repeat;Serine/threonine-protein kinase;Transferase;Zinc

apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; cell chemotaxis [GO:0060326]; cellular response to angiotensin [GO:1904385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; cellular senescence [GO:0090398]; defense response to bacterium [GO:0042742]; DNA damage response [GO:0006974]; immunoglobulin mediated immune response [GO:0016064]; intracellular signal transduction [GO:0035556]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of platelet aggregation [GO:0090331]; neutrophil activation [GO:0042119]; phosphorylation [GO:0016310]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of glucosylceramide catabolic process [GO:2000753]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of sphingomyelin catabolic process [GO:2000755]; positive regulation of superoxide anion generation [GO:0032930]; post-translational protein modification [GO:0043687]; termination of signal transduction [GO:0023021]

cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; nuclear matrix [GO:0016363]; plasma membrane [GO:0005886]

ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; enzyme activator activity [GO:0008047]; insulin receptor substrate binding [GO:0043560]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.

IPR046349;IPR000008;IPR035892;IPR020454;IPR011009;IPR002219;IPR027436;IPR014376;IPR000719;IPR017441;IPR008271;

3.30.60.20;2.60.40.150;1.10.510.10;

A0A5F8AFL2

MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGIVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQNSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKTVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSTPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSSTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPTMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTAPLQHHGQLAQPGALNLPMGYGPRMQQPSNQSQFLPQTQFPSQGMNVTNMPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLAPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIPEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMEPTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPTANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWGQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGVSPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQSQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQMGQLPQALGAEAGASLQAYQQRLLQQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH

Macaca mulatta (Rhesus macaque)

2.3.1.48

Acyltransferase;Biological rhythms;Bromodomain;Cytoplasm;Isopeptide bond;Metal-binding;Methylation;Nucleus;Phosphoprotein;Reference proteome;Repeat;Transcription;Transcription regulation;Transferase;Ubl conjugation;Zinc;Zinc-finger

animal organ morphogenesis [GO:0009887]; B cell differentiation [GO:0030183]; behavioral defense response [GO:0002209]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; learning or memory [GO:0007611]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; megakaryocyte development [GO:0035855]; multicellular organism growth [GO:0035264]; negative regulation of autophagy [GO:0010507]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of glycolytic process [GO:0006110]; regulation of mitochondrion organization [GO:0010821]; regulation of tubulin deacetylation [GO:0090043]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; swimming [GO:0036268]; thigmotaxis [GO:0001966]; transcription initiation-coupled chromatin remodeling [GO:0045815]

cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]

acetylation-dependent protein binding [GO:0140033]; beta-catenin binding [GO:0008013]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; histone acetyltransferase activity [GO:0004402]; histone butyryltransferase activity [GO:0140069]; histone crotonyltransferase activity [GO:0140068]; histone H2B acetyltransferase activity [GO:0044013]; histone H3K122 acetyltransferase activity [GO:0140908]; histone H3K18 acetyltransferase activity [GO:0043993]; histone H3K27 acetyltransferase activity [GO:0044017]; histone H4 acetyltransferase activity [GO:0010485]; histone lactyltransferase activity [GO:0120301]; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468]; NF-kappaB binding [GO:0051059]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; pre-mRNA intronic binding [GO:0097157]; protein propionyltransferase activity [GO:0061920]; STAT family protein binding [GO:0097677]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; zinc ion binding [GO:0008270]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR001487;IPR036427;IPR018359;IPR031162;IPR013178;IPR003101;IPR036529;IPR009110;IPR014744;IPR037073;IPR010303;IPR038547;IPR035898;IPR013083;IPR000197;IPR000433;IPR043145;

2.10.110.40;3.30.60.90;1.20.920.10;1.10.246.20;1.10.1630.10;1.20.1020.10;3.30.40.10;

A0A5F8AFR4

MISFNNICVNGEFVIVLGLGRNCFIHIHRYMNHVRTRRGLQDDTNSDCCLFFIGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR

Macaca mulatta (Rhesus macaque)

3.4.24.81

CATALYTIC ACTIVITY: Reaction=Endopeptidase of broad specificity.; EC=3.4.24.81; Evidence={ECO:0000256|ARBA:ARBA00001809};

COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00001947};

Cleavage on pair of basic residues;Membrane;Metal-binding;Phosphoprotein;Reference proteome;SH3-binding;Signal;Transmembrane;Transmembrane helix;Zinc

adherens junction organization [GO:0034332]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; in utero embryonic development [GO:0001701]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612]; toxin transport [GO:1901998]

adherens junction [GO:0005912]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; tetraspanin-enriched microdomain [GO:0097197]

metal ion binding [GO:0046872]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]

SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000256|ARBA:ARBA00004132}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004614}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR034025;IPR049038;IPR001762;IPR036436;IPR024079;IPR001590;

3.40.390.10;4.10.70.10;

A0A5F8AH52

MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPIIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLTSPADAAGFLHSSRDSGGSKDSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAVRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSVGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSVPEHSTRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGMVMAPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPEPGSTESLQEKPMEIAPSAGCGGSLHPGARAGGASSPSPVVFTVGSPPSGSTPPQGPRTRMFSVGSTGSAGSSARHLVSGACSEAPAPELPAPGHSCSFADPIAANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRVHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVAKCKLCIERRLSALLTGICA

Macaca mulatta (Rhesus macaque)

FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation. {ECO:0000256|PIRNR:PIRNR000580}.

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|PIRNR:PIRNR000580}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|PIRNR:PIRNR000580};

ATP-binding;Autophagy;Kinase;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

autophagosome assembly [GO:0000045]; axon extension [GO:0048675]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of protein-containing complex assembly [GO:0031333]; phosphorylation [GO:0016310]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagy [GO:0010508]; protein localization [GO:0008104]; regulation of macroautophagy [GO:0016241]; regulation of protein lipidation [GO:1903059]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]

Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; omegasome membrane [GO:1903349]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]

ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; small GTPase binding [GO:0031267]

IPR045269;IPR048941;IPR022708;IPR011009;IPR000719;IPR017441;IPR016237;IPR008271;

1.10.510.10;

A0A5F8AJN1

MAEYKRLHNALALIRLRNPPVNAISTAVLRDVKEGLQKAVIDHTIKAIVICGAEGKFSAGADIHGFSAPRTFGLTLGHVVDEIQRNVKPVVAAIQGMAFGGGLELALGCHYRIAHTEAQVGLPEVTLGLLPGARGTQLLPRLIGVPAALDLITSGRHILAGEALKLGILDKVVNSDPVEEAIRFAQTVSDQPLESRRLCNKPIQSLPNMDTIFSEVLLKMQKQHPGCLAQEACVRAVQAAVQYPYEVGIKKEEELFLYLFQSGQARALQYAFFAERKANKWSTPSGASWKTASAQPVSSVGVVGLGTMGRGIVISFARAGIPVIAVDSDKNQLATANKIITSVLEKEASKMQQSGHPWSGPKPKLTSSMKELGGVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIASSTDHPHLVIGTHFFSPAHVMKLLEVIPSRYSSPTTIATVMNLSKKIKKIGVVVGNCFGFVGNRMLNPYYNQTYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKGQGLTGPTLPPGTPARKRGNRRYCPIPDMLCELGRFGQKTGKGWYQYDKPLGRIHKPDPWLSKFLSQYRETYHIEPRTISQDEILERCLYSLINEAFHILGEGIATSPEHIDVVYLHGYGWPRHKGGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKEWQSLAGSPSSNL

Macaca mulatta (Rhesus macaque)

1.1.1.35; 4.2.1.17; 5.3.3.8

CATALYTIC ACTIVITY: Reaction=(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA; Xref=Rhea:RHEA:40259, ChEBI:CHEBI:15377, ChEBI:CHEBI:77075, ChEBI:CHEBI:77080; Evidence={ECO:0000256|ARBA:ARBA00036989}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40260; Evidence={ECO:0000256|ARBA:ARBA00036989}; CATALYTIC ACTIVITY: Reaction=(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O; Xref=Rhea:RHEA:31119, ChEBI:CHEBI:15377, ChEBI:CHEBI:57312, ChEBI:CHEBI:57337; Evidence={ECO:0000256|ARBA:ARBA00036472}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31121; Evidence={ECO:0000256|ARBA:ARBA00036472}; CATALYTIC ACTIVITY: Reaction=(3E)-decenoyl-CoA = (2E)-decenoyl-CoA; Xref=Rhea:RHEA:45752, ChEBI:CHEBI:61406, ChEBI:CHEBI:84793; Evidence={ECO:0000256|ARBA:ARBA00036656}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45753; Evidence={ECO:0000256|ARBA:ARBA00036656}; CATALYTIC ACTIVITY: Reaction=(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA; Xref=Rhea:RHEA:45736, ChEBI:CHEBI:62077, ChEBI:CHEBI:84790; Evidence={ECO:0000256|ARBA:ARBA00036353}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45737; Evidence={ECO:0000256|ARBA:ARBA00036353}; CATALYTIC ACTIVITY: Reaction=(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA; Xref=Rhea:RHEA:49932, ChEBI:CHEBI:85108, ChEBI:CHEBI:131990; Evidence={ECO:0000256|ARBA:ARBA00035863}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:49934; Evidence={ECO:0000256|ARBA:ARBA00035863}; CATALYTIC ACTIVITY: Reaction=(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA; Xref=Rhea:RHEA:47464, ChEBI:CHEBI:71586, ChEBI:CHEBI:87701; Evidence={ECO:0000256|ARBA:ARBA00036570}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:47466; Evidence={ECO:0000256|ARBA:ARBA00036570}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62548, ChEBI:CHEBI:62616; Evidence={ECO:0000256|ARBA:ARBA00001391}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31188; Evidence={ECO:0000256|ARBA:ARBA00001391}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O; Xref=Rhea:RHEA:31191, ChEBI:CHEBI:15377, ChEBI:CHEBI:61406, ChEBI:CHEBI:62616; Evidence={ECO:0000256|ARBA:ARBA00035760}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31193; Evidence={ECO:0000256|ARBA:ARBA00035760}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:40267, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:77080, ChEBI:CHEBI:77081; Evidence={ECO:0000256|ARBA:ARBA00036386}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40268; Evidence={ECO:0000256|ARBA:ARBA00036386}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:31159, ChEBI:CHEBI:15378, ChEBI:CHEBI:57349, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62613; Evidence={ECO:0000256|ARBA:ARBA00000193}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31160; Evidence={ECO:0000256|ARBA:ARBA00000193}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O; Xref=Rhea:RHEA:31163, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526, ChEBI:CHEBI:62613; Evidence={ECO:0000256|ARBA:ARBA00000469}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31165; Evidence={ECO:0000256|ARBA:ARBA00000469}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O; Xref=Rhea:RHEA:30547, ChEBI:CHEBI:15377, ChEBI:CHEBI:62075, ChEBI:CHEBI:62077; Evidence={ECO:0000256|ARBA:ARBA00036370}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30549; Evidence={ECO:0000256|ARBA:ARBA00036370}; CATALYTIC ACTIVITY: Reaction=(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA; Xref=Rhea:RHEA:45748, ChEBI:CHEBI:62077, ChEBI:CHEBI:85415; Evidence={ECO:0000256|ARBA:ARBA00036336}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45749; Evidence={ECO:0000256|ARBA:ARBA00036336}; CATALYTIC ACTIVITY: Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; EC=5.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00035949}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45229; Evidence={ECO:0000256|ARBA:ARBA00035949}; CATALYTIC ACTIVITY: Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35; Evidence={ECO:0000256|ARBA:ARBA00036547}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22433; Evidence={ECO:0000256|ARBA:ARBA00036547}; CATALYTIC ACTIVITY: Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489; EC=5.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00035959}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45901; Evidence={ECO:0000256|ARBA:ARBA00035959}; CATALYTIC ACTIVITY: Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521, ChEBI:CHEBI:137480; EC=4.2.1.17; Evidence={ECO:0000256|ARBA:ARBA00035909}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20725; Evidence={ECO:0000256|ARBA:ARBA00035909};

PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000256|ARBA:ARBA00005005}.

Acetylation;Fatty acid metabolism;Lipid metabolism;NAD;Peroxisome;Reference proteome

fatty acid beta-oxidation [GO:0006635]

peroxisome [GO:0005777]

3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; enoyl-CoA hydratase activity [GO:0004300]; enzyme binding [GO:0019899]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]

SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.

IPR006180;IPR006176;IPR006108;IPR008927;IPR029045;IPR018376;IPR001753;IPR036291;

1.10.1040.50;3.40.50.720;

A0A5F8AKI0

MAEPSGSPVHVQLPQQAAPVTAAATAPAAATAAPAPAAPAAPAPAPAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVNASTIPEQIQSLSVHDSQSPPSANEDYREAASCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS

Macaca mulatta (Rhesus macaque)

2.7.11.1

CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00001433}; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};

ATP-binding;Cytoplasm;Kinase;Nucleotide-binding;Reference proteome;Transferase

cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; cellular hypotonic response [GO:0071476]; cellular response to potassium ion [GO:0035865]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; inflammatory response [GO:0006954]; intracellular chloride ion homeostasis [GO:0030644]; intracellular signal transduction [GO:0035556]; macrophage activation [GO:0042116]; maintenance of lens transparency [GO:0036438]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; phosphorylation [GO:0016310]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of T cell chemotaxis [GO:0010820]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; renal sodium ion absorption [GO:0070294]; response to aldosterone [GO:1904044]; response to dietary excess [GO:0002021]; sodium ion transmembrane transport [GO:0035725]

apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]

ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.

IPR011009;IPR024678;IPR000719;IPR017441;

1.10.510.10;

A0A5F8ALZ2

MPSPRRSVEGRPLGVSASSSSSSSPGSPAHGGGGGGSRFEFQSLLSSRATGVDPTCARLRASESPVHRRGSFPLAAAGPSQAPPPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR

Macaca mulatta (Rhesus macaque)

3.6.1.68

CATALYTIC ACTIVITY: Reaction=(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:47944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58057, ChEBI:CHEBI:88107; EC=3.6.1.68; Evidence={ECO:0000256|ARBA:ARBA00035809}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47945; Evidence={ECO:0000256|ARBA:ARBA00035809}; CATALYTIC ACTIVITY: Reaction=(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate; Xref=Rhea:RHEA:68020, ChEBI:CHEBI:15377, ChEBI:CHEBI:17447, ChEBI:CHEBI:43474, ChEBI:CHEBI:88107; Evidence={ECO:0000256|ARBA:ARBA00036169}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68021; Evidence={ECO:0000256|ARBA:ARBA00036169}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:48128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226, ChEBI:CHEBI:175763; Evidence={ECO:0000256|ARBA:ARBA00037020}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48129; Evidence={ECO:0000256|ARBA:ARBA00037020}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate; Xref=Rhea:RHEA:48132, ChEBI:CHEBI:15377, ChEBI:CHEBI:16619, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226; Evidence={ECO:0000256|ARBA:ARBA00036036}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48133; Evidence={ECO:0000256|ARBA:ARBA00036036}; CATALYTIC ACTIVITY: Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:68008, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58756, ChEBI:CHEBI:144936; Evidence={ECO:0000256|ARBA:ARBA00035926}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68009; Evidence={ECO:0000256|ARBA:ARBA00035926}; CATALYTIC ACTIVITY: Reaction=(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate; Xref=Rhea:RHEA:68016, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46762, ChEBI:CHEBI:144936; Evidence={ECO:0000256|ARBA:ARBA00036255}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68017; Evidence={ECO:0000256|ARBA:ARBA00036255}; CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000256|ARBA:ARBA00001611}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence={ECO:0000256|ARBA:ARBA00001611}; CATALYTIC ACTIVITY: Reaction=H2O + presqualene diphosphate = H(+) + phosphate + presqualene phosphate; Xref=Rhea:RHEA:67968, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57310, ChEBI:CHEBI:176803; Evidence={ECO:0000256|ARBA:ARBA00036000}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67969; Evidence={ECO:0000256|ARBA:ARBA00036000}; CATALYTIC ACTIVITY: Reaction=H2O + presqualene phosphate = phosphate + presqualene alcohol; Xref=Rhea:RHEA:68024, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:176803, ChEBI:CHEBI:176962; Evidence={ECO:0000256|ARBA:ARBA00035802}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68025; Evidence={ECO:0000256|ARBA:ARBA00035802};

Hydrolase;Lipid metabolism;Membrane;Nucleus;Reference proteome;Transmembrane;Transmembrane helix

farnesyl diphosphate catabolic process [GO:0045339]; geranyl diphosphate metabolic process [GO:0033383]; geranylgeranyl diphosphate catabolic process [GO:1902247]; phospholipid dephosphorylation [GO:0046839]; positive regulation of neutrophil activation [GO:1902565]

endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear inner membrane [GO:0005637]

isoprenoid diphosphate phosphatase activity [GO:0106405]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane {ECO:0000256|ARBA:ARBA00004370}. Nucleus envelope {ECO:0000256|ARBA:ARBA00004259}. Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004540}.

IPR036938;IPR000326;

1.20.144.10;

A0A5F8AMU1

MSTVYVEKNAQILVICPLSFHKPNTPCGQEAALPTTGSAPPGPGDQDFPKGPANVRKEGRKGGRGREECWLLSSAPFGFGLCRGLKAALRAPGWQGGVVAAADSKEPPETQSWARRATRAPALAKGHVRPHWMQPRPGPGHILKTTGVWGSAPGLSARGPRYIAQAQKRTAERWPRRAEGARFQLRPRSVLRGGARGGPGAGRAQGARGAGTGTGRGRRRGAGGGSASWARVSAAAMAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIQQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRTAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTAQTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEAIQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISQGHTVYVVHDGFEGLAKGQVQVVGWHNVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF

Macaca mulatta (Rhesus macaque)

FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. {ECO:0000256|HAMAP-Rule:MF_03184}.

2.7.1.11

CATALYTIC ACTIVITY: Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634, ChEBI:CHEBI:456216; EC=2.7.1.11; Evidence={ECO:0000256|ARBA:ARBA00000432, ECO:0000256|HAMAP-Rule:MF_03184};

COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|HAMAP-Rule:MF_03184};

PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000256|ARBA:ARBA00004679, ECO:0000256|HAMAP-Rule:MF_03184}.

Acetylation;Allosteric enzyme;ATP-binding;Cytoplasm;Glycolysis;Kinase;Magnesium;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Transferase

canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; negative regulation of insulin secretion [GO:0046676]; response to glucose [GO:0009749]

6-phosphofructokinase complex [GO:0005945]; membrane [GO:0016020]

6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03184}.

IPR009161;IPR022953;IPR041914;IPR015912;IPR000023;IPR035966;

3.40.50.450;3.40.50.460;

A0A5F8ANJ3

MAPDGSRTLRELHAGGGVQGEGIYAACGGEGGFSGSMKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKYPEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYDGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESDDDSHFEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVRDDVDNGDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDVSMPLPFDLTDIVSELRAEYQSTINTMLPGAISCFKFASQICCSGSQGRCSIKKRKKSDTDPSQERSGGDCRKLGKLS

Macaca mulatta (Rhesus macaque)

1.14.11.53

CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57900, Rhea:RHEA-COMP:13573, Rhea:RHEA-COMP:13574, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; Evidence={ECO:0000256|ARBA:ARBA00000560}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57904, Rhea:RHEA-COMP:15030, Rhea:RHEA-COMP:15031, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85958, ChEBI:CHEBI:85959; Evidence={ECO:0000256|ARBA:ARBA00000383}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:57896, Rhea:RHEA-COMP:11518, Rhea:RHEA-COMP:11519, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:85958, ChEBI:CHEBI:85959; Evidence={ECO:0000256|ARBA:ARBA00000305}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:54576, Rhea:RHEA-COMP:10242, Rhea:RHEA-COMP:12312, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74491; Evidence={ECO:0000256|ARBA:ARBA00001575}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate; Xref=Rhea:RHEA:49520, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=1.14.11.53; Evidence={ECO:0000256|ARBA:ARBA00033605};

COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|ARBA:ARBA00001954};

Cytoplasm;Dioxygenase;Iron;Metal-binding;Nucleus;Oxidoreductase;Reference proteome

adipose tissue development [GO:0060612]; DNA dealkylation involved in DNA repair [GO:0006307]; mRNA destabilization [GO:0061157]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of brown fat cell differentiation [GO:0090335]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; temperature homeostasis [GO:0001659]

cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]

broad specificity oxidative DNA demethylase activity [GO:0035516]; ferrous iron binding [GO:0008198]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; tRNA demethylase activity [GO:1990984]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.

IPR037151;IPR032868;IPR024366;IPR038413;IPR024367;

2.60.120.590;1.20.58.1470;

A0A5F8AQ28

MNEQESVLTQLPLRTLGRRGRSCARVGWRERTPRPACRRAGVRAPGSGNRTESKERGMELWAARACFVLLWGCALAPATAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQSLARFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEVSESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPMSMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCESSVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGSLAVIGGVAVCVVLLLLLAGAGFFIHRRRKNLRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGTLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVVSKYKPMMIITEFMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI

Macaca mulatta (Rhesus macaque)

2.7.10.1

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000256|ARBA:ARBA00001171};

ATP-binding;Disulfide bond;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Receptor;Reference proteome;Signal;Transferase;Transmembrane;Transmembrane helix;Tyrosine-protein kinase

axial mesoderm formation [GO:0048320]; axon guidance [GO:0007411]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cAMP metabolic process [GO:0046058]; cell chemotaxis [GO:0060326]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; neural tube development [GO:0021915]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of bicellular tight junction assembly [GO:1903348]; positive regulation of cell migration [GO:0030335]; positive regulation of protein localization to plasma membrane [GO:1903078]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570]

cell surface [GO:0009986]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; leading edge membrane [GO:0031256]; receptor complex [GO:0043235]; tight junction [GO:0070160]

ATP binding [GO:0005524]; growth factor binding [GO:0019838]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane-ephrin receptor activity [GO:0005005]

SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.

IPR027936;IPR034263;IPR001090;IPR003961;IPR036116;IPR008979;IPR009030;IPR013783;IPR011009;IPR000719;IPR017441;IPR001660;IPR013761;IPR001245;IPR008266;IPR020635;IPR016257;IPR001426;

2.60.40.1770;2.60.120.260;2.60.40.10;1.20.5.510;1.10.150.50;1.10.510.10;2.10.50.10;

A0A5F8AQS9

MACPWKFLFKTKFHQYTMTGGKDINNNMEKAACATSSLVTQDDLQYHSLSKQQNESPQPLVGTGKKSPESLVKPDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARNCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQADGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYSLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELTNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSSVTWDPHHYRLVQDSQPLDLSKALSNVHAKNVFTMRLKSRQNLQSLTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPAPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEATERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTQDGQGPLHHGVCSTWLNSLKPRDPVPCFIRNASGFHLPEDPSHPCILVGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHEEPGHLYVCGDVRMAWDVAHTLKQLVAAKLNLNEEQVEDYFFQLKRARSAIMKISLVLYFPTRRRRTGRQCSPGAWRCQPSDGPTGGVKTADTELNRGASSEVTGPGGMEKSDIPQPQVLFPHFVPHQALYLTSYQVAPWIDRSLLSQAGASLVPWRRTLQCQTWQVGERWNPLLSAPLHVTTRRCCCATVYLTALCTVIYASVFKKLTPQSAPSGHLGLPCMIP

Macaca mulatta (Rhesus macaque)

FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions. {ECO:0000256|PIRNR:PIRNR000333}.

1.14.13.39

CATALYTIC ACTIVITY: Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence={ECO:0000256|ARBA:ARBA00035595}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19898; Evidence={ECO:0000256|ARBA:ARBA00035595};

COFACTOR: Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence={ECO:0000256|ARBA:ARBA00001950}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FAD. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FMN. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000256|ARBA:ARBA00001970, ECO:0000256|PIRNR:PIRNR000333};

Calmodulin-binding;FAD;Flavoprotein;FMN;Heme;Iron;Metal-binding;NADP;Oxidoreductase;Reference proteome

arginine catabolic process [GO:0006527]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to type II interferon [GO:0071346]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of killing of cells of another organism [GO:0051712]; prostaglandin secretion [GO:0032310]; regulation of cell population proliferation [GO:0042127]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of insulin secretion [GO:0050796]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; superoxide metabolic process [GO:0006801]

cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]

arginine binding [GO:0034618]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitric-oxide synthase activity [GO:0004517]; protein homodimerization activity [GO:0042803]; tetrahydrobiopterin binding [GO:0034617]

IPR003097;IPR017927;IPR001094;IPR008254;IPR001709;IPR029039;IPR039261;IPR023173;IPR044943;IPR044940;IPR044944;IPR012144;IPR004030;IPR036119;IPR001433;IPR017938;

3.40.50.360;6.10.250.410;3.90.440.10;3.40.50.80;2.40.30.10;

A0A5F8ARL5

MGREELYLTFSFSSGFQESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENIKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKYVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQITFVPQNQTTESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSVLELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMNFLNLTSEKVSQEKVTEMMKKFCSQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLVIVAIIGLLIFHKPSYFWKDMV

Macaca mulatta (Rhesus macaque)

3.6.1.5

CATALYTIC ACTIVITY: Reaction=2 H2O + ITP = 2 H(+) + IMP + 2 phosphate; Xref=Rhea:RHEA:77735, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; Evidence={ECO:0000256|ARBA:ARBA00043682}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77736; Evidence={ECO:0000256|ARBA:ARBA00043682}; CATALYTIC ACTIVITY: Reaction=2 H2O + UTP = 2 H(+) + 2 phosphate + UMP; Xref=Rhea:RHEA:64896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:57865; Evidence={ECO:0000256|ARBA:ARBA00043678}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64897; Evidence={ECO:0000256|ARBA:ARBA00043678}; CATALYTIC ACTIVITY: Reaction=ADP + H2O = AMP + H(+) + phosphate; Xref=Rhea:RHEA:61436, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036139}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61437; Evidence={ECO:0000256|ARBA:ARBA00036139}; CATALYTIC ACTIVITY: Reaction=ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:20988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00043702}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20989; Evidence={ECO:0000256|ARBA:ARBA00043702}; CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00034440}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; Evidence={ECO:0000256|ARBA:ARBA00034440}; CATALYTIC ACTIVITY: Reaction=CDP + H2O = CMP + H(+) + phosphate; Xref=Rhea:RHEA:64880, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00043676}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64881; Evidence={ECO:0000256|ARBA:ARBA00043676}; CATALYTIC ACTIVITY: Reaction=CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:64908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00043680}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64909; Evidence={ECO:0000256|ARBA:ARBA00043680}; CATALYTIC ACTIVITY: Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; Evidence={ECO:0000256|ARBA:ARBA00043776}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; Evidence={ECO:0000256|ARBA:ARBA00043776}; CATALYTIC ACTIVITY: Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; Evidence={ECO:0000256|ARBA:ARBA00043654}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; Evidence={ECO:0000256|ARBA:ARBA00043654}; CATALYTIC ACTIVITY: Reaction=GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:64904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115; Evidence={ECO:0000256|ARBA:ARBA00043766}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64905; Evidence={ECO:0000256|ARBA:ARBA00043766}; CATALYTIC ACTIVITY: Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000256|ARBA:ARBA00001702}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670; Evidence={ECO:0000256|ARBA:ARBA00001702}; CATALYTIC ACTIVITY: Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; Evidence={ECO:0000256|ARBA:ARBA00043688}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; Evidence={ECO:0000256|ARBA:ARBA00043688}; CATALYTIC ACTIVITY: Reaction=H2O + ITP = H(+) + IDP + phosphate; Xref=Rhea:RHEA:28330, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; Evidence={ECO:0000256|ARBA:ARBA00043752}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28331; Evidence={ECO:0000256|ARBA:ARBA00043752}; CATALYTIC ACTIVITY: Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; Evidence={ECO:0000256|ARBA:ARBA00043716}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; Evidence={ECO:0000256|ARBA:ARBA00043716}; CATALYTIC ACTIVITY: Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; Evidence={ECO:0000256|ARBA:ARBA00043661}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64901; Evidence={ECO:0000256|ARBA:ARBA00043661}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; Evidence={ECO:0000256|ARBA:ARBA00043714}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; Evidence={ECO:0000256|ARBA:ARBA00043714}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; Evidence={ECO:0000256|ARBA:ARBA00043753}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36796; Evidence={ECO:0000256|ARBA:ARBA00043753}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; Evidence={ECO:0000256|ARBA:ARBA00043686}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; Evidence={ECO:0000256|ARBA:ARBA00043686};

COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00001913}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946};

ATP-binding;Calcium;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Nucleotide-binding;Reference proteome;Transmembrane;Transmembrane helix

nucleoside diphosphate catabolic process [GO:0009134]; platelet aggregation [GO:0070527]

caveola [GO:0005901]; plasma membrane [GO:0005886]

ATP binding [GO:0005524]; GDP phosphatase activity [GO:0004382]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]

SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR000407;

3.30.420.40;3.30.420.150;

A0A5F8ASS9

MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL

Macaca mulatta (Rhesus macaque)

2.7.10.2

CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000256|ARBA:ARBA00001149, ECO:0000256|RuleBase:RU362096};

COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936};

ATP-binding;Cytoplasm;Kinase;Lipoprotein;Nucleotide-binding;Palmitate;Reference proteome;SH2 domain;SH3 domain;Transferase;Tyrosine-protein kinase

activated T cell proliferation [GO:0050798]; cell differentiation [GO:0030154]; cellular response to amyloid-beta [GO:1904646]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendrite morphogenesis [GO:0048813]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; forebrain development [GO:0030900]; gene expression [GO:0010467]; heart process [GO:0003015]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; neuron migration [GO:0001764]; phosphorylation [GO:0016310]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell shape [GO:0008360]; regulation of glutamate receptor signaling pathway [GO:1900449]; response to ethanol [GO:0045471]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

actin filament [GO:0005884]; cell body [GO:0044297]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glial cell projection [GO:0097386]; membrane raft [GO:0045121]; postsynaptic density [GO:0014069]; Schaffer collateral - CA1 synapse [GO:0098685]

alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; ephrin receptor binding [GO:0046875]; G protein-coupled receptor binding [GO:0001664]; growth factor receptor binding [GO:0070851]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; scaffold protein binding [GO:0097110]; signaling receptor binding [GO:0005102]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]

IPR047924;IPR035750;IPR011009;IPR000719;IPR017441;IPR001245;IPR000980;IPR036860;IPR036028;IPR001452;IPR008266;IPR020635;

3.30.505.10;2.30.30.40;1.10.510.10;

A0A5F8AUQ8

MGSRLGARGSVGGAQGAIFSSLPGTSASPDSPSQKPAGEGGLASCPRNGQDHLLLRPLSHDPPTAVFLAPQQVFLAPQQALSLLQRVRRASSGFLEEVFKGNLERECVEETCSYEEAFEALESSTATDAFWAKYTACETARTSRDTLAACLEGNCAEDLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRREECSIPVCGQDQVTVAMTPRSSVNLSLPSEECVPDRGRQYQGHLAVTTHGLPCLAWASAQAKALSKHQDFDSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFEYCDLNYCEEAVDEETGDGLGEDPDRAIEGRTATSEYQTFFDPRTFGLGEADCGLRPLFEKKSLEDKTEGELLESYIDGRIVEGWDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRETAASLFQAGYKGRVTGWGNLKETWTTNVGKVQPSVLQVVNLPIVERSVCKDSTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKNPLNKRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQEVIDQFGD

Macaca mulatta (Rhesus macaque)

FUNCTION: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. {ECO:0000256|ARBA:ARBA00025390}.

3.4.21.5

CATALYTIC ACTIVITY: Reaction=Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.; EC=3.4.21.5; Evidence={ECO:0000256|ARBA:ARBA00001621};

Acute phase;Blood coagulation;Cleavage on pair of basic residues;Disulfide bond;Gamma-carboxyglutamic acid;Hemostasis;Hydrolase;Kringle;Protease;Reference proteome;Serine protease;Signal

acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; G protein-coupled receptor signaling pathway [GO:0007186]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]

collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]

calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053]

IPR035972;IPR000294;IPR000001;IPR013806;IPR018056;IPR038178;IPR009003;IPR043504;IPR001314;IPR003966;IPR018992;IPR037111;IPR001254;IPR018114;IPR033116;

2.40.20.10;4.10.140.10;2.40.10.10;

A0A5F8G8W5

MGHCFSHDSIKTNEEQGLPKADAEKLKGVKIIFVVGGPGSGKGTQCEKIVEKYGFTHLSSGDLLREEVRSGSERGKTLSEIMEKGELVPLDTVLDMLKEAILAKAETSKGFLIDGYPREVAQGEAFEKKIGSPTLLLYIDAGSETMVERLLKRGETSGRVDDNEETIKSRLKTYYSATEPVIKFYEGRGIVRRINAEGSVESVFEEVCTHLDALN

Monodelphis domestica (Gray short-tailed opossum)

FUNCTION: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000256|HAMAP-Rule:MF_03171}.

2.7.4.3; 2.7.4.6

CATALYTIC ACTIVITY: Reaction=ADP + thiamine diphosphate = AMP + thiamine triphosphate; Xref=Rhea:RHEA:69180, ChEBI:CHEBI:58937, ChEBI:CHEBI:58938, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00034400}; CATALYTIC ACTIVITY: Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence={ECO:0000256|HAMAP-Rule:MF_03171}; CATALYTIC ACTIVITY: Reaction=ATP + GDP = ADP + GTP; Xref=Rhea:RHEA:27686, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034442}; CATALYTIC ACTIVITY: Reaction=ATP + UDP = ADP + UTP; Xref=Rhea:RHEA:25098, ChEBI:CHEBI:30616, ChEBI:CHEBI:46398, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034451}; CATALYTIC ACTIVITY: Reaction=ATP + dGDP = ADP + dGTP; Xref=Rhea:RHEA:27690, ChEBI:CHEBI:30616, ChEBI:CHEBI:58595, ChEBI:CHEBI:61429, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034407}; CATALYTIC ACTIVITY: Reaction=ATP + dTDP = ADP + dTTP; Xref=Rhea:RHEA:27682, ChEBI:CHEBI:30616, ChEBI:CHEBI:37568, ChEBI:CHEBI:58369, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|ARBA:ARBA00034432}; CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|HAMAP-Rule:MF_03171}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000256|HAMAP-Rule:MF_03171}; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP; Xref=Rhea:RHEA:13749, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.10; Evidence={ECO:0000256|ARBA:ARBA00034410};

ATP-binding;Cytoplasm;Kinase;Nucleotide-binding;Reference proteome;Transferase

ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; nucleoside triphosphate biosynthetic process [GO:0009142]; phosphorylation [GO:0016310]

cytoplasm [GO:0005737]; cytosol [GO:0005829]

adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; cytidylate kinase activity [GO:0004127]; nucleoside diphosphate kinase activity [GO:0004550]; nucleoside triphosphate adenylate kinase activity [GO:0046899]

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_03171}.

DOMAIN: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. {ECO:0000256|HAMAP-Rule:MF_03171}.

IPR000850;IPR033690;IPR028582;IPR006267;IPR027417;

3.40.50.300;

A0A5F8GBD0

MFDKTRLPFVALDMVCLLLAAMPLIVLNLAKIKPYQRGFFCSDNSIKYPYHDSTVPSPLLYAVGFTLPISSMILGEALSVYYNLLHSNSFVRNNYIATIYKAIGTFIFGAAASQSLTDIAKYSIGRLRPHFLAVCDPDWTQFNCSDGYIENFPCRGDAGIVNEGRLSFYSGHSSFSMYCMLFLALYLQARMKADWARLLRPTLQFAFIALSIYVGLSRVSDYKHHWSDVLTGLIQGAVVAILVVILVSDFFEERTCPYKQRKEEDSHTTLHETPTNGNHYGSNHQA

Monodelphis domestica (Gray short-tailed opossum)

3.1.3.106; 3.1.3.4; 3.6.1.75

CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence={ECO:0000256|ARBA:ARBA00000974}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50885; Evidence={ECO:0000256|ARBA:ARBA00000974}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence={ECO:0000256|ARBA:ARBA00000980}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43245; Evidence={ECO:0000256|ARBA:ARBA00000980}; CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000256|ARBA:ARBA00001611}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence={ECO:0000256|ARBA:ARBA00001611}; CATALYTIC ACTIVITY: Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence={ECO:0000256|ARBA:ARBA00000235}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence={ECO:0000256|ARBA:ARBA00000235}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:41255, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466; Evidence={ECO:0000256|ARBA:ARBA00023681}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41256; Evidence={ECO:0000256|ARBA:ARBA00023681}; CATALYTIC ACTIVITY: Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence={ECO:0000256|ARBA:ARBA00001542}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62161; Evidence={ECO:0000256|ARBA:ARBA00001542}; CATALYTIC ACTIVITY: Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence={ECO:0000256|ARBA:ARBA00001710}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62041; Evidence={ECO:0000256|ARBA:ARBA00001710}; CATALYTIC ACTIVITY: Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence={ECO:0000256|ARBA:ARBA00001476}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46737; Evidence={ECO:0000256|ARBA:ARBA00001476}; CATALYTIC ACTIVITY: Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence={ECO:0000256|ARBA:ARBA00001716}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27519; Evidence={ECO:0000256|ARBA:ARBA00001716}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence={ECO:0000256|ARBA:ARBA00001180}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27430; Evidence={ECO:0000256|ARBA:ARBA00001180}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=3.6.1.75; Evidence={ECO:0000256|ARBA:ARBA00035886}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:27450; Evidence={ECO:0000256|ARBA:ARBA00035886}; CATALYTIC ACTIVITY: Reaction=a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:33155, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57970, ChEBI:CHEBI:64683; EC=3.1.3.106; Evidence={ECO:0000256|ARBA:ARBA00001472}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33156; Evidence={ECO:0000256|ARBA:ARBA00001472}; CATALYTIC ACTIVITY: Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence={ECO:0000256|ARBA:ARBA00023977}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33744; Evidence={ECO:0000256|ARBA:ARBA00023977};

PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000256|ARBA:ARBA00005074}.; PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.

Cell membrane;Hydrolase;Lipid metabolism;Membrane;Reference proteome;Transmembrane;Transmembrane helix

phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]

apical plasma membrane [GO:0016324]; caveola [GO:0005901]; plasma membrane [GO:0005886]

lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]

SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}. Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane raft {ECO:0000256|ARBA:ARBA00004314}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004314}. Membrane, caveola {ECO:0000256|ARBA:ARBA00004189}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004189}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.

IPR036938;IPR000326;IPR043216;

1.20.144.10;