id
string | words
sequence | boxes
sequence | question
string | answer
string |
|---|---|---|---|---|
544 | [
"4)",
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">",
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"US",
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"Cal",
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"as",
"in",
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"issues",
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"with",
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"o",
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"expected",
"in",
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"2004",
"Risk",
"Management",
"-",
"component",
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"comprehensive",
"product",
"stewardship",
"pre-market/",
"clinical",
"development",
"post-marketing",
"General",
"Discussion",
"ALL",
"Question",
"1",
"-",
"Japan's",
"role",
"in",
"RM;",
"Who",
"will",
"direct",
"company's",
"position?",
"Suggestion",
"from",
"Glyn:",
"TGRD",
"would",
"formulate",
"direct",
"Risk",
"Management",
"plan",
"and",
"obtain",
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"input,",
"`Takeda",
"Forum",
"Risk",
"Management",
"March",
"22,",
"2004",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-BAROND-00208932",
"Produced",
"in",
"MDL",
"on",
"09/02/12",
"Source:",
"https://www.induspop56-00602s.ucsf.edu/docs/gmjf0226"
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544 | [
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">",
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588 | [
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544 | [
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">",
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] | What is the Suggestion from Glyn? | tgrd would formulate direct risk management plan and obtain japan's input |
588 | [
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"Source:",
"https://www.industrydocup27-00902",
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] | what is the executive summary of bladder cancer cases ? | CONFIRM |
544 | [
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">",
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"-",
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588 | [
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] | what is the name of the request document ? | PARTIAL CLINICAL HOLD REMOVAL REQUEST DOCUMENT |
545 | [
"PENGAD",
"BOO-631-698",
"EXHIBIT",
"102",
"FDA",
"Conference",
"Call",
"on",
"July",
"31,",
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"Michael",
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"Hoos,",
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"Affairs",
"John",
"Page,",
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"Alfonso",
"Perez,",
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"Director",
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"Mary",
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"Thom,",
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"Weber,",
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"data",
"recently",
"received",
"by",
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] | On the purpose of teleconference, how many topics were to be discussed? | 3 |
545 | [
"PENGAD",
"BOO-631-698",
"EXHIBIT",
"102",
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"on",
"July",
"31,",
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"Vice",
"President,",
"of",
"Medial",
"and",
"Scientific",
"Affairs",
"Michael",
"Elisseou,",
"Ph.D.,",
"Director,",
"Product",
"Development",
"and",
"Planning",
"Janet",
"Haskins,",
"Manager,",
"Regulatory",
"Affairs",
"Ingrid",
"Hoos,",
"Director,",
"Regulatory",
"Affairs",
"John",
"Page,",
"M.D.,",
"Director.",
"Product",
"Safety",
"Alfonso",
"Perez,",
"M.D.,",
"Sr.",
"Director",
"of",
"Clinical",
"Development",
"Mary",
"Ramstack,",
"Sr.",
"Manager,",
"Product",
"Development",
"and",
"Planning",
"Claire",
"Thom,",
"Pharm.D.,",
"Vice",
"President,",
"Research",
"and",
"Development",
"FDA",
"Personnel:",
"David",
"Orloff,",
"M.D.,",
"Division",
"Director",
"Bob",
"Misbin,",
"M.D.,",
"Medical",
"Review",
"Jena",
"Weber,",
"Project",
"Manager",
"Jeri",
"El-Hage,",
"Toxicology",
"Team",
"Leader",
"Dr.",
"Orloff",
"stated",
"that",
"the",
"purpose",
"of",
"the",
"teleconference",
"was",
"to",
"discuss",
"three",
"topics",
"related",
"to",
"additional",
"nonclinical",
"data",
"recently",
"received",
"by",
"the",
"Division",
"1.",
"a",
"proposal",
"to",
"monitor",
"bladder",
"toxicily",
"in",
"long",
"term",
"clinical",
"trials",
"2.",
"the",
"Division's",
"inclination",
"to",
"rescind",
"the",
"written",
"request",
"for",
"pediatric",
"exclusivity",
"3.",
"a",
"labeling",
"change",
"that",
"would",
"reflect",
"possible",
"relatedness",
"of",
"tumor",
"formation",
"to",
"drug",
"mechanism",
"of",
"action.",
"Dr.",
"Orloff",
"stated_that",
"the",
"Division",
"is",
"considering",
"additional",
"data",
"that",
"indicates",
"that",
"the",
"bladder",
"tumors",
"seen",
"in",
"the",
"rat",
"carcinogenicity",
"study",
"maybe",
"a",
"mixed",
"PPAR",
"class",
"effect.",
"He",
"further",
"noted",
"that",
"when",
"proglitazone",
"was",
"approved",
"by",
"the",
"Division,",
"the",
"significance",
"of",
"these",
"findings",
"was",
"tempered",
"by",
"the",
"data",
"presented",
"by",
"Takeda",
"relating",
"the",
"tumor",
"formation",
"to",
"the",
"presence",
"of",
"calculi.",
"He",
"further",
"indicated",
"that",
"However",
",",
"as",
"the",
"Division",
"has",
"recently",
"reviewed",
"data",
"for",
"similar",
"compounds.",
"the",
"additional.",
"Additional",
"data",
"suggests",
"that",
"those",
"tumors",
"may",
"have",
"beenbe-",
"drug",
"related.",
"Dr.",
"Perez",
"inquired",
"about",
"the",
"Division's",
"definition",
"of",
"long",
"term",
"trials",
"and",
"stated",
"that",
"urine",
"cytology",
"was",
"preformed",
"in",
"two",
"trials",
"that",
"were",
"over",
"one",
"year",
"in",
"duration.",
"Dr.",
"Misbin",
"noted",
"that",
"the",
"Division",
"considers",
"long-term",
"as",
"a",
"trial",
"longer",
"than",
"one-year",
"and",
"inquired",
"about",
"what",
"type",
"of",
"testing",
"was",
"conducted",
"in",
"the",
"trials",
"mentioned",
"by",
"Dr.",
"Perez.",
"Dr.",
"Perez",
"noted",
"that",
"urine",
"cytology",
"was",
"performed",
"for",
"any",
"subject",
"presenting",
"hematuria",
"at",
"any",
"time",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00235775",
"Produced",
"in",
"MDL",
"on",
"09/18/12",
"Source:",
"https://www.indup53670boots.ucsf.edu/docs/fsjf0226"
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] | What is the date mentioned at the bottom? | 09/18/12 |
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343,
974,
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596 | [
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[
289,
976,
340,
996
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[
343,
974,
711,
996
]
] | What are shown on the x-axis? | FULL MONTHS POST LAUNCH |
596 | [
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343,
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711,
996
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[
231,
982,
298,
996
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[
302,
979,
772,
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] | What is the date of randomisation? | 05-11-01 |
598 | [
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602 | [
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966,
979,
979
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231,
982,
298,
996
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302,
979,
772,
997
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] | What is the patient number? | 014 |
602 | [
"04/05/2004",
"11:05",
"22434/2084",
"12:0",
"49-931-20136759",
"NORL",
"*",
"9004993123136283",
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"35037-hrt-11",
"92-04-04",
"Date",
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"Alert",
"Report",
"Booklet",
"A15778",
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"appreci-",
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"At",
"A",
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"could",
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"attached",
"questionnaire",
"and",
"return",
"it",
"to",
"is",
"with",
"this",
"enquiry",
"form",
"signed",
"and",
"card",
"as",
"soon",
"as",
"possible.",
"Reply:",
"was",
"no",
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"a",
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"turnor",
"see",
"the",
"diagnosis",
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"the",
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"Signature:",
"C",
"Beds",
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"provided",
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"that",
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"reply",
"is",
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"sheet",
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"the",
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"please",
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"Coordinating",
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"44",
"115",
"956",
"77",
"22)",
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"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-INDNDA-00456053",
"Produced",
"in",
"MDL",
"on",
"09/12/12",
"Source:",
"https://www.indupoo26-ooocats.ucsf.edu/docs/rljf0226"
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554,
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412,
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473,
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473,
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473,
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484
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473,
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474,
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484
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474,
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720,
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483,
195,
493
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274,
483,
300,
493
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483,
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493
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384,
493
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483,
418,
493
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483,
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493
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483,
478,
493
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483,
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494
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483,
517,
494
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518,
483,
534,
494
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537,
483,
565,
494
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567,
483,
629,
494
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484,
664,
494
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484,
684,
494
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686,
484,
698,
494
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484,
720,
494
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491,
198,
502
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201,
491,
214,
502
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216,
491,
232,
502
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234,
492,
253,
502
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255,
492,
282,
503
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285,
492,
302,
503
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[
304,
492,
339,
503
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[
341,
493,
351,
503
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[
352,
493,
368,
503
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[
371,
493,
412,
503
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[
414,
493,
440,
503
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442,
493,
476,
503
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478,
493,
506,
503
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54,
947,
130,
960
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132,
948,
143,
960
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146,
949,
195,
960
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198,
949,
212,
960
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[
215,
949,
281,
960
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[
284,
949,
327,
960
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[
778,
950,
934,
964
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771,
965,
837,
978
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[
840,
966,
854,
978
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[
857,
966,
891,
978
],
[
894,
966,
912,
979
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[
916,
966,
979,
979
],
[
231,
982,
298,
996
],
[
302,
979,
772,
997
]
] | What is the Centre number? | 49013 |
598 | [
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"on",
"09/14/12",
"Source:",
"https://www.indupp45200002s.ucsf.edu/docs/ymjf0226"
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79
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352,
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231,
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377,
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396,
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403,
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490,
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535,
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122,
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359,
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114,
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220
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"04/05/2004",
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] | What is the Reference mentioned here? | 135037-HRT-11 |
604 | [
"NDA",
"21-073/8-023",
"Page",
"13",
"in",
"insulin",
"combination",
"studies,",
"a",
"small",
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"(",
"Table",
"6).",
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"accumulation.",
"Table",
"6",
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"160",
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"338",
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"10",
"26",
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"anovulatory",
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"a",
"result,",
"these",
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"be",
"at",
"an",
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"while",
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"in",
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"women",
"should",
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"recommended.",
"This",
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"effect",
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"in",
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"the",
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"this",
"occurrence",
"is",
"not",
"known.",
"Hematologic:",
"ACTOS",
"may",
"cause",
"decreases",
"in",
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"and",
"hematocrit.",
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"all",
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"any",
"significant",
"hematologic",
"clinical",
"effects",
"(see",
"ADVERSE",
"REACTIONS,",
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"Source:",
"https://www.industrybethents.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062920"
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786,
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834
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835
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225,
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292,
997
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[
296,
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776,
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842,
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986
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650,
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678,
639
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305,
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372,
656
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376,
641,
394,
656
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397,
641,
426,
656
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430,
641,
521,
656
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275,
690,
348,
706
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479,
690,
504,
705
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507,
691,
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608,
691,
653,
706
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657,
690,
720,
706
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275,
723,
348,
738
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275,
741,
324,
755
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328,
742,
382,
756
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275,
757,
325,
771
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329,
758,
379,
771
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276,
773,
322,
787
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275,
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342,
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277,
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320,
820
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654,
811,
668,
818
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654,
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668,
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652,
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667,
785
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651,
744,
667,
752
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650,
728,
667,
735
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918,
918,
929,
929
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71,
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149,
968
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152,
955,
162,
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165,
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217,
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230,
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233,
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300,
968
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303,
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344,
968
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791,
955,
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230,
982,
298,
997
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301,
982,
500,
998
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[
503,
980,
771,
998
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] | what is the total number of drug claims under the title of "summary of litigation risk in the ous territories"? | 5 |
606 | [
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"or",
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"Endpoints:",
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"mortality",
"9/18/2013",
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"Confidential",
"Copyright",
"@",
"2000",
"Eli",
"Lilly",
"and",
"Company",
"PLA-TAK-00053926",
"Source:",
"https://www.indup634orooorts.ucsf.edu/docs/fzjf0226"
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342,
996
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344,
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710,
996
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] | what are secondary endpoints ? | CARDIOVASCULAR MORTALITY |
608 | [
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],
[
648,
719,
669,
748
],
[
673,
718,
835,
747
],
[
838,
717,
858,
744
],
[
375,
749,
405,
777
],
[
409,
750,
436,
777
],
[
132,
779,
243,
807
],
[
246,
779,
366,
807
],
[
374,
780,
519,
807
],
[
522,
780,
604,
807
],
[
68,
854,
107,
868
],
[
397,
856,
433,
868
],
[
435,
854,
480,
868
],
[
397,
867,
433,
880
],
[
435,
867,
441,
880
],
[
443,
867,
462,
880
],
[
463,
867,
473,
880
],
[
474,
867,
490,
880
],
[
492,
867,
506,
880
],
[
508,
867,
545,
881
],
[
855,
934,
965,
952
],
[
290,
976,
342,
996
],
[
344,
974,
710,
996
]
] | What is the number of patients ? | 5,000 |
606 | [
"PROactive",
"Objective:",
"Demonstrate",
"that",
"pioglitazone",
"reduces",
"total",
"mortality",
"and",
"macrovascular",
"morbidity",
"in",
"high-risk",
"patients",
"with",
"type",
"2",
"diabetes",
"mellitus",
"Number",
"of",
"patients:",
"5,000",
"Countries:",
"Austria,",
"Belgium,",
"Czech",
"Republic,",
"Denmark,",
"Estonia,",
"Finland,",
"France,",
"Germany,",
"Hungary,",
"Italy,",
"Latvia,",
"Lithuania,",
"Netherlands,",
"Norway,",
"Poland,",
"Sweden,",
"Switzerland,",
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"FPV:",
"June",
"2001",
"LPV:",
"Q2",
"2005",
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"Endpoints:",
"All-cause",
"mortality,",
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"MI,",
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"intervention,",
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"major",
"leg",
"amputation,",
"bypass",
"surgery,",
"or",
"revascularisation",
"in",
"the",
"leg",
"Secondary",
"Endpoints:",
"Cardiovascular",
"mortality",
"9/18/2013",
"Company",
"Confidential",
"Copyright",
"@",
"2000",
"Eli",
"Lilly",
"and",
"Company",
"PLA-TAK-00053926",
"Source:",
"https://www.indup634orooorts.ucsf.edu/docs/fzjf0226"
] | [
[
85,
136,
287,
187
],
[
132,
273,
236,
299
],
[
374,
278,
496,
305
],
[
502,
278,
540,
305
],
[
543,
278,
657,
305
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[
661,
278,
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305
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[
745,
278,
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302
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[
372,
309,
456,
336
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[
460,
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496,
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[
500,
308,
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[
646,
308,
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336
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[
737,
307,
756,
335
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[
760,
306,
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335
],
[
373,
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368
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[
453,
340,
494,
368
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[
498,
339,
540,
368
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[
544,
339,
558,
368
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[
566,
339,
645,
368
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[
648,
340,
721,
367
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[
130,
382,
214,
411
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[
218,
382,
240,
411
],
[
243,
381,
335,
412
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[
373,
382,
428,
408
],
[
132,
430,
238,
455
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[
374,
431,
447,
459
],
[
452,
431,
537,
459
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[
542,
431,
602,
459
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[
606,
431,
698,
459
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[
702,
431,
793,
459
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[
373,
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453,
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457,
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[
539,
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617,
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[
716,
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[
809,
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855,
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373,
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437,
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441,
492,
536,
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[
540,
492,
663,
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667,
492,
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751,
492,
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375,
523,
460,
551
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[
463,
523,
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552
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[
585,
523,
614,
552
],
[
132,
552,
179,
578
],
[
376,
556,
422,
581
],
[
427,
555,
472,
582
],
[
131,
601,
179,
624
],
[
374,
602,
405,
629
],
[
409,
602,
457,
629
],
[
131,
652,
213,
682
],
[
217,
653,
327,
685
],
[
374,
656,
463,
683
],
[
467,
656,
556,
684
],
[
559,
657,
645,
685
],
[
648,
657,
681,
685
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[
685,
657,
739,
685
],
[
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657,
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685
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[
374,
688,
476,
716
],
[
480,
687,
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[
554,
687,
673,
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[
677,
687,
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[
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687,
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],
[
805,
687,
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[
376,
719,
487,
747
],
[
491,
719,
562,
748
],
[
566,
719,
644,
748
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[
648,
719,
669,
748
],
[
673,
718,
835,
747
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[
838,
717,
858,
744
],
[
375,
749,
405,
777
],
[
409,
750,
436,
777
],
[
132,
779,
243,
807
],
[
246,
779,
366,
807
],
[
374,
780,
519,
807
],
[
522,
780,
604,
807
],
[
68,
854,
107,
868
],
[
397,
856,
433,
868
],
[
435,
854,
480,
868
],
[
397,
867,
433,
880
],
[
435,
867,
441,
880
],
[
443,
867,
462,
880
],
[
463,
867,
473,
880
],
[
474,
867,
490,
880
],
[
492,
867,
506,
880
],
[
508,
867,
545,
881
],
[
855,
934,
965,
952
],
[
290,
976,
342,
996
],
[
344,
974,
710,
996
]
] | What is "FPV" ? | JUNE 2001 |
604 | [
"NDA",
"21-073/8-023",
"Page",
"13",
"in",
"insulin",
"combination",
"studies,",
"a",
"small",
"number",
"of",
"patients",
"with",
"a",
"history",
"of",
"previously",
"existing",
"cardiac",
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"congestive",
"heart",
"failure",
"when",
"treated",
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"ACTOS",
"in",
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"with",
"insulin",
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"ill",
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"status,",
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"ACTOS,",
"cases",
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"failure",
"have",
"been",
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"in",
"patients",
"both",
"with",
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"without",
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"known",
"heart",
"disease.",
"Edema:",
"ACTOS",
"should",
"be",
"used",
"with",
"caution",
"in",
"patients",
"with",
"edema,",
"In",
"all",
"U.S.",
"clinical",
"trials.",
"edema",
"was",
"reported",
"more",
"frequently",
"in",
"patients",
"treated",
"with",
"ACTOS",
"than",
"in",
"placebo-treated",
"patients",
"and",
"appears",
"to",
"be",
"dose",
"related",
"(see",
"ADVERSE",
"REACTIONS).",
"In",
"postmarketing",
"experience,",
"reports",
"of",
"initiation",
"or",
"worsening",
"of",
"edema",
"have",
"been",
"received.",
"Weight",
"Gain:",
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"related",
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"was",
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"and",
"in",
"combination",
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"agents",
"(",
"Table",
"6).",
"The",
"mechanism",
"of",
"weight",
"gain",
"is",
"unclear",
"but",
"probably",
"involves",
"a",
"combination",
"of",
"fluid",
"retention",
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"fat",
"accumulation.",
"Table",
"6",
"Weight",
"Changes",
"(kg)",
"from",
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"with",
"ACTOS",
"Control",
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"ACTOS",
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"15",
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"30",
"mg",
"15",
"mg",
"Median",
"Median",
"Median",
"Median",
"(25",
"/75",
"(25",
"/75",
"(25",
"/75",
"(25/75",
"percentile)",
"percentile)",
"percentile)",
"percentile)",
"Monotherapy",
"-1,4",
"(-2.7/0.0)",
"0.9(-0.5/3.4)",
"1.0(-0.9/3.4)",
"2.6",
"(0.2/5.4)",
"n=256",
"n",
"=",
"79",
"1=188",
"n",
"=",
"79",
"Combination",
"Sulfonylurea",
"-D.5",
"(-1.8/0.7)",
"2.0",
"(0.2/3.2)",
"3.1",
"(1.1/5.4)",
"4.1",
"(1.8/7.3)",
"n=187",
"1=183",
"1=528",
"N-333",
"Therapy",
"Metformin",
"-1.4",
"(-3.2/0.3)",
"1=",
"160",
"N/A",
"0.9(-0.3/3.2)",
"1.8(-0.9/5.0)",
"1=567",
"N=407",
"Insulin",
"0.2",
"(-1.4/1.4)",
"2.3",
"(0.5/4.3)",
"3.3",
"(0.9/6.3)",
":1523",
"4.1",
"(1.4/6.8)",
"n=",
"182",
"1=190",
"N=",
"338",
"Note:",
"Trial",
"durations",
"of",
"16",
"10",
"26",
"weeks",
"Ovulation:",
"Therapy",
"with",
"ACTOS,",
"like",
"other",
"thiazolidinediones,",
"may",
"result",
"in",
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"in",
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"premenopausal",
"anovulatory",
"women.",
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"a",
"result,",
"these",
"patients",
"may",
"be",
"at",
"an",
"increased",
"risk",
"for",
"pregnancy",
"while",
"taking",
"ACTOS.",
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"in",
"premenopausal",
"women",
"should",
"be",
"recommended.",
"This",
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"not",
"been",
"investigated",
"in",
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"studies",
"so",
"the",
"frequency",
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"this",
"occurrence",
"is",
"not",
"known.",
"Hematologic:",
"ACTOS",
"may",
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"decreases",
"in",
"hemoglobin",
"and",
"hematocrit.",
"Across",
"all",
"clinical",
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"patients",
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"with",
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"changes",
"primarily",
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"within",
"the",
"first",
"4",
"to",
"12",
"weeks",
"of",
"therapy",
"and",
"remained",
"relatively",
"constant",
"thereafter.",
"These",
"changes",
"may",
"be",
"related",
"to",
"increased",
"plasma",
"volume",
"and",
"have",
"rarely",
"been",
"associated",
"with",
"any",
"significant",
"hematologic",
"clinical",
"effects",
"(see",
"ADVERSE",
"REACTIONS,",
"Laboratory",
"Abnormalities).",
"Source:",
"https://www.industrybethents.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062920"
] | [
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61,
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508,
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620,
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636,
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705,
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171
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745,
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130,
186
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603,
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668,
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687,
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115,
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174,
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208,
267
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212,
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279,
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284,
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330,
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415,
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] | What is the ACTOS 15 mg of Monotherapy? | 0.9(-0.5/3.4) N=79 |
604 | [
"NDA",
"21-073/8-023",
"Page",
"13",
"in",
"insulin",
"combination",
"studies,",
"a",
"small",
"number",
"of",
"patients",
"with",
"a",
"history",
"of",
"previously",
"existing",
"cardiac",
"disease",
"developed",
"congestive",
"heart",
"failure",
"when",
"treated",
"with",
"ACTOS",
"in",
"combination",
"with",
"insulin",
"(see",
"WARNINGS).",
"Patients",
"with",
"NYHA",
"Class",
"ill",
"and",
"IV",
"cardiac",
"status",
"were",
"not",
"studied",
"in",
"these",
"ACTOS",
"clinical",
"trials.",
"ACTOS",
"is",
"not",
"indicated",
"in",
"patients",
"with",
"NYHA",
"Class",
"Ill",
"or",
"IV",
"cardiac",
"status,",
"In",
"postmarketing",
"experience",
"with",
"ACTOS,",
"cases",
"of",
"congestive",
"heart",
"failure",
"have",
"been",
"reported",
"in",
"patients",
"both",
"with",
"and",
"without",
"previously",
"known",
"heart",
"disease.",
"Edema:",
"ACTOS",
"should",
"be",
"used",
"with",
"caution",
"in",
"patients",
"with",
"edema,",
"In",
"all",
"U.S.",
"clinical",
"trials.",
"edema",
"was",
"reported",
"more",
"frequently",
"in",
"patients",
"treated",
"with",
"ACTOS",
"than",
"in",
"placebo-treated",
"patients",
"and",
"appears",
"to",
"be",
"dose",
"related",
"(see",
"ADVERSE",
"REACTIONS).",
"In",
"postmarketing",
"experience,",
"reports",
"of",
"initiation",
"or",
"worsening",
"of",
"edema",
"have",
"been",
"received.",
"Weight",
"Gain:",
"Dose",
"related",
"weight",
"gain",
"was",
"seen",
"with",
"ACTOS",
"alone",
"and",
"in",
"combination",
"with",
"other",
"hypoglycemic",
"agents",
"(",
"Table",
"6).",
"The",
"mechanism",
"of",
"weight",
"gain",
"is",
"unclear",
"but",
"probably",
"involves",
"a",
"combination",
"of",
"fluid",
"retention",
"and",
"fat",
"accumulation.",
"Table",
"6",
"Weight",
"Changes",
"(kg)",
"from",
"Baseline",
"during",
"Double-Blind",
"Clinical",
"Trials",
"with",
"ACTOS",
"Control",
"Group",
"ACTOS",
"ACTOS",
"ACTOS",
"Placebo)",
"15",
"mg",
"30",
"mg",
"15",
"mg",
"Median",
"Median",
"Median",
"Median",
"(25",
"/75",
"(25",
"/75",
"(25",
"/75",
"(25/75",
"percentile)",
"percentile)",
"percentile)",
"percentile)",
"Monotherapy",
"-1,4",
"(-2.7/0.0)",
"0.9(-0.5/3.4)",
"1.0(-0.9/3.4)",
"2.6",
"(0.2/5.4)",
"n=256",
"n",
"=",
"79",
"1=188",
"n",
"=",
"79",
"Combination",
"Sulfonylurea",
"-D.5",
"(-1.8/0.7)",
"2.0",
"(0.2/3.2)",
"3.1",
"(1.1/5.4)",
"4.1",
"(1.8/7.3)",
"n=187",
"1=183",
"1=528",
"N-333",
"Therapy",
"Metformin",
"-1.4",
"(-3.2/0.3)",
"1=",
"160",
"N/A",
"0.9(-0.3/3.2)",
"1.8(-0.9/5.0)",
"1=567",
"N=407",
"Insulin",
"0.2",
"(-1.4/1.4)",
"2.3",
"(0.5/4.3)",
"3.3",
"(0.9/6.3)",
":1523",
"4.1",
"(1.4/6.8)",
"n=",
"182",
"1=190",
"N=",
"338",
"Note:",
"Trial",
"durations",
"of",
"16",
"10",
"26",
"weeks",
"Ovulation:",
"Therapy",
"with",
"ACTOS,",
"like",
"other",
"thiazolidinediones,",
"may",
"result",
"in",
"ovulation",
"in",
"some",
"premenopausal",
"anovulatory",
"women.",
"As",
"a",
"result,",
"these",
"patients",
"may",
"be",
"at",
"an",
"increased",
"risk",
"for",
"pregnancy",
"while",
"taking",
"ACTOS.",
"Thus,",
"adequate",
"contraception",
"in",
"premenopausal",
"women",
"should",
"be",
"recommended.",
"This",
"possible",
"effect",
"has",
"not",
"been",
"investigated",
"in",
"clinical",
"studies",
"so",
"the",
"frequency",
"of",
"this",
"occurrence",
"is",
"not",
"known.",
"Hematologic:",
"ACTOS",
"may",
"cause",
"decreases",
"in",
"hemoglobin",
"and",
"hematocrit.",
"Across",
"all",
"clinical",
"studies,",
"mean",
"hemoglobin",
"values",
"declined",
"by",
"2%",
"to",
"4%",
"in",
"patients",
"treated",
"with",
"ACTOS.",
"These",
"changes",
"primarily",
"occurred",
"within",
"the",
"first",
"4",
"to",
"12",
"weeks",
"of",
"therapy",
"and",
"remained",
"relatively",
"constant",
"thereafter.",
"These",
"changes",
"may",
"be",
"related",
"to",
"increased",
"plasma",
"volume",
"and",
"have",
"rarely",
"been",
"associated",
"with",
"any",
"significant",
"hematologic",
"clinical",
"effects",
"(see",
"ADVERSE",
"REACTIONS,",
"Laboratory",
"Abnormalities).",
"Source:",
"https://www.industrybethents.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062920"
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[
646,
770,
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[
714,
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774,
784
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[
776,
770,
809,
784
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[
111,
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[
191,
786,
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[
245,
786,
315,
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[
319,
787,
390,
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[
393,
787,
465,
802
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[
469,
787,
516,
802
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520,
786,
547,
802
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550,
786,
582,
801
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585,
786,
597,
801
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786,
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623,
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643,
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646,
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723,
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785,
800
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788,
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800
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113,
803,
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[
192,
803,
266,
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270,
803,
340,
819
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[
344,
802,
434,
819
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[
437,
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489,
819
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[
493,
802,
563,
818
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[
566,
802,
601,
818
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[
605,
802,
627,
818
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[
631,
802,
688,
818
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[
691,
802,
708,
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[
711,
802,
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817
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796,
802,
853,
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[
116,
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172,
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175,
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834
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251,
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[
352,
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439,
835
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[
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479,
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482,
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[
517,
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597,
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[
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818,
701,
835
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[
705,
818,
762,
834
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[
766,
818,
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834
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823,
818,
859,
834
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[
112,
835,
199,
850
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316,
850
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320,
835,
410,
851
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413,
835,
535,
851
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225,
981,
292,
997
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[
296,
980,
776,
997
],
[
842,
974,
984,
986
]
] | What is the trial duration mentioned? | 16 TO 26 WEEKS |
610 | [
"84/05/2004",
"11:05",
"49",
"931",
"20136759",
"32/04/2004",
"19-931-20136759",
"12:03",
"NCRL",
"+",
"9004993129136283",
"DIABETESAMBULANZ",
"01/03",
"NO.",
"938",
"0302",
"PROactive",
"Urgent",
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"Centre",
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"Patient",
"number",
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"Date",
"of",
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"9013",
"05:1",
"1:01",
"Reference",
"Date",
"Issued",
"32-04-04",
"Date",
"resolved",
"135036-17thrunet-10",
"Atat",
"Report",
"Booklet",
"A",
"15776",
"(page",
"001)",
"._.-04,",
"Benign",
"tumor",
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"bla",
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"Of:",
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"As",
"the",
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"for",
"this",
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"this",
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"as",
"a",
"GAL.",
"Other",
"hospitalisation",
"should",
"only",
"be",
"ticked",
"for",
"admission",
"to",
"hospital",
"for",
"a",
"procedure",
"or",
"treatment",
"for",
"an",
"event",
"which",
"is",
"not",
"new",
"of",
"has",
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"worsened",
"after",
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"We",
"have",
"murefore",
"ticked",
"box",
"01",
"and",
"box:10,",
"Please",
"confirm",
"that",
"we",
"may",
"remove",
"the",
"ticks",
"from",
"Dax",
"06",
"and",
"box",
"14.",
"Reply:",
"Okay",
"15",
"Alert",
"Report",
"Booklet",
"A15778",
"(page",
"(01)",
".....-04,",
"Benign",
"tumor",
"of",
"the",
"urinary",
"bla",
"ITEM",
"21:",
"Details:",
"summary",
"of",
"relevant",
"medical",
"details",
"Please",
"provide",
"a",
"brief",
"description",
"of",
"the",
"events/symptoms",
"which",
"lead",
"to",
"the",
"panion",
"being",
"hospitalised.",
"Reply:",
"The",
"patient",
"had",
"a",
"macro",
"fematuria",
"16",
"Alert",
"Report",
"Booklet",
"A15778",
"(page",
"006).-.04:",
"Benign",
"tumor",
"of",
"the",
"urmary",
"bia",
"ITEM",
"50:",
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"/",
"addmonal",
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"detale",
"The",
"date",
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"so",
"1604-04",
"however",
"we",
"note",
"that",
"this",
"is",
"2",
"months",
"after",
"the",
"date",
"of",
"#scharge.",
"Please",
"provide",
"details",
"of",
"any",
"treatment",
"given",
"to",
"the",
"patient",
"after",
"discharge.",
"Reply:",
"sonyi",
"had",
"was",
"a",
"mistake",
"Date",
"resolution",
"is",
"of",
"course",
"Signature:",
"-",
"Bell",
"Date:",
"$415",
"104",
"Please",
"write",
"your",
"reply",
"in",
"the",
"space",
"provided",
"and",
"ensure",
"that",
"the",
"reply",
"is",
"signed",
"as",
"this",
"sheet",
"will",
"become",
"part",
"of",
"he",
"patient's",
"tucord",
"form.",
"Once",
"completed,",
"please",
"fax",
"the",
"form",
"back",
"to",
"the",
"Study",
"Coordinating",
"Centre",
"(+",
"+",
"44",
"115",
"956",
"77",
"22)",
"and",
"retain",
"the",
"original",
"in",
"the",
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"Case",
"Report",
"Form.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-INDNDA-00456052",
"Produced",
"in",
"MDL",
"on",
"09/12/12",
"Source:",
"https://www.indupoo26-oooo2ts.ucsf.edu/docs/rljf0226"
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610 | [
"84/05/2004",
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"treatment",
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"murefore",
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"01",
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] | what is the centre number ? | 49013 |
604 | [
"NDA",
"21-073/8-023",
"Page",
"13",
"in",
"insulin",
"combination",
"studies,",
"a",
"small",
"number",
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"patients",
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"a",
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"congestive",
"heart",
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"ACTOS",
"in",
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"with",
"insulin",
"(see",
"WARNINGS).",
"Patients",
"with",
"NYHA",
"Class",
"ill",
"and",
"IV",
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"patients",
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"with",
"ACTOS",
"than",
"in",
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"patients",
"and",
"appears",
"to",
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"dose",
"related",
"(see",
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"REACTIONS).",
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"experience,",
"reports",
"of",
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"or",
"worsening",
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"edema",
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"in",
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"(",
"Table",
"6).",
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"a",
"combination",
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"retention",
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"fat",
"accumulation.",
"Table",
"6",
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"ACTOS",
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"(25",
"/75",
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"-1,4",
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"0.9(-0.5/3.4)",
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"2.6",
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"1=528",
"N-333",
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"Metformin",
"-1.4",
"(-3.2/0.3)",
"1=",
"160",
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":1523",
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"182",
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"N=",
"338",
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"16",
"10",
"26",
"weeks",
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"ACTOS,",
"like",
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"thiazolidinediones,",
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"in",
"some",
"premenopausal",
"anovulatory",
"women.",
"As",
"a",
"result,",
"these",
"patients",
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"an",
"increased",
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"women",
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"effect",
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"Hematologic:",
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"in",
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"4%",
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"These",
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"to",
"12",
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"These",
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"be",
"related",
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"increased",
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"volume",
"and",
"have",
"rarely",
"been",
"associated",
"with",
"any",
"significant",
"hematologic",
"clinical",
"effects",
"(see",
"ADVERSE",
"REACTIONS,",
"Laboratory",
"Abnormalities).",
"Source:",
"https://www.industrybethents.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062920"
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] | What is the date mentioned? | August 12-13, 2002 |
610 | [
"84/05/2004",
"11:05",
"49",
"931",
"20136759",
"32/04/2004",
"19-931-20136759",
"12:03",
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"1:01",
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"Date",
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"32-04-04",
"Date",
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"135036-17thrunet-10",
"Atat",
"Report",
"Booklet",
"A",
"15776",
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"001)",
"._.-04,",
"Benign",
"tumor",
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"this",
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"GAL.",
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"should",
"only",
"be",
"ticked",
"for",
"admission",
"to",
"hospital",
"for",
"a",
"procedure",
"or",
"treatment",
"for",
"an",
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"which",
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"new",
"of",
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"have",
"murefore",
"ticked",
"box",
"01",
"and",
"box:10,",
"Please",
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"that",
"we",
"may",
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"06",
"and",
"box",
"14.",
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"Okay",
"15",
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"Report",
"Booklet",
"A15778",
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"Benign",
"tumor",
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"the",
"panion",
"being",
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"had",
"a",
"macro",
"fematuria",
"16",
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"Report",
"Booklet",
"A15778",
"(page",
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"bia",
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"/",
"addmonal",
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"detale",
"The",
"date",
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"1604-04",
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"note",
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"2",
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"date",
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"Please",
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"of",
"any",
"treatment",
"given",
"to",
"the",
"patient",
"after",
"discharge.",
"Reply:",
"sonyi",
"had",
"was",
"a",
"mistake",
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"resolution",
"is",
"of",
"course",
"Signature:",
"-",
"Bell",
"Date:",
"$415",
"104",
"Please",
"write",
"your",
"reply",
"in",
"the",
"space",
"provided",
"and",
"ensure",
"that",
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"reply",
"is",
"signed",
"as",
"this",
"sheet",
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"become",
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"he",
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"Once",
"completed,",
"please",
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"form",
"back",
"to",
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"Coordinating",
"Centre",
"(+",
"+",
"44",
"115",
"956",
"77",
"22)",
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"retain",
"the",
"original",
"in",
"the",
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"Case",
"Report",
"Form.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-INDNDA-00456052",
"Produced",
"in",
"MDL",
"on",
"09/12/12",
"Source:",
"https://www.indupoo26-oooo2ts.ucsf.edu/docs/rljf0226"
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] | what is the date issued mentioned in the form ? | 22-04-04 |
610 | [
"84/05/2004",
"11:05",
"49",
"931",
"20136759",
"32/04/2004",
"19-931-20136759",
"12:03",
"NCRL",
"+",
"9004993129136283",
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"Date",
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"9013",
"05:1",
"1:01",
"Reference",
"Date",
"Issued",
"32-04-04",
"Date",
"resolved",
"135036-17thrunet-10",
"Atat",
"Report",
"Booklet",
"A",
"15776",
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"001)",
"._.-04,",
"Benign",
"tumor",
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"bla",
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"As",
"the",
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"was",
"hospitalised",
"for",
"this",
"event,",
"this",
"qualifies",
"as",
"a",
"GAL.",
"Other",
"hospitalisation",
"should",
"only",
"be",
"ticked",
"for",
"admission",
"to",
"hospital",
"for",
"a",
"procedure",
"or",
"treatment",
"for",
"an",
"event",
"which",
"is",
"not",
"new",
"of",
"has",
"not",
"worsened",
"after",
"randomisation.",
"We",
"have",
"murefore",
"ticked",
"box",
"01",
"and",
"box:10,",
"Please",
"confirm",
"that",
"we",
"may",
"remove",
"the",
"ticks",
"from",
"Dax",
"06",
"and",
"box",
"14.",
"Reply:",
"Okay",
"15",
"Alert",
"Report",
"Booklet",
"A15778",
"(page",
"(01)",
".....-04,",
"Benign",
"tumor",
"of",
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"bla",
"ITEM",
"21:",
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"summary",
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"a",
"brief",
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"the",
"events/symptoms",
"which",
"lead",
"to",
"the",
"panion",
"being",
"hospitalised.",
"Reply:",
"The",
"patient",
"had",
"a",
"macro",
"fematuria",
"16",
"Alert",
"Report",
"Booklet",
"A15778",
"(page",
"006).-.04:",
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"tumor",
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"bia",
"ITEM",
"50:",
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"new",
"/",
"addmonal",
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"detale",
"The",
"date",
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"so",
"1604-04",
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"we",
"note",
"that",
"this",
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"2",
"months",
"after",
"the",
"date",
"of",
"#scharge.",
"Please",
"provide",
"details",
"of",
"any",
"treatment",
"given",
"to",
"the",
"patient",
"after",
"discharge.",
"Reply:",
"sonyi",
"had",
"was",
"a",
"mistake",
"Date",
"resolution",
"is",
"of",
"course",
"Signature:",
"-",
"Bell",
"Date:",
"$415",
"104",
"Please",
"write",
"your",
"reply",
"in",
"the",
"space",
"provided",
"and",
"ensure",
"that",
"the",
"reply",
"is",
"signed",
"as",
"this",
"sheet",
"will",
"become",
"part",
"of",
"he",
"patient's",
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"form.",
"Once",
"completed,",
"please",
"fax",
"the",
"form",
"back",
"to",
"the",
"Study",
"Coordinating",
"Centre",
"(+",
"+",
"44",
"115",
"956",
"77",
"22)",
"and",
"retain",
"the",
"original",
"in",
"the",
"patient's",
"Case",
"Report",
"Form.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-INDNDA-00456052",
"Produced",
"in",
"MDL",
"on",
"09/12/12",
"Source:",
"https://www.indupoo26-oooo2ts.ucsf.edu/docs/rljf0226"
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614 | [
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614 | [
"TPNA/TEUR&D/TCI",
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"12-13,",
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547,
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769,
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617 | [
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"In",
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"of",
"Retention",
"shall",
"immediately",
"take",
"necessary",
"measures.",
"For",
"documents",
"this",
"Division",
"retains,",
"we",
"shall",
"have",
"it",
"made",
"at",
"each",
"control",
"unit",
"in",
"accordance",
"with",
"the",
"format",
"of",
"Attachment",
"1,",
"and",
"shall",
"stipulate",
"the",
"retention",
"time",
"period",
"and",
"retention",
"location",
"by",
"specific",
"type",
"of",
"such",
"document.",
"Further,",
"regardless",
"of",
"the",
"retention",
"time",
"period",
"that",
"has",
"been",
"stipulated,",
"when",
"it",
"is",
"recognized",
"to",
"be",
"necessary",
"in",
"work",
"duties,",
"based",
"on",
"the",
"determination",
"of",
"the",
"Person",
"Responsible",
"for",
"Retention",
"(the",
"Head",
"of",
"the",
"Pharmaceutical",
"Research",
"Division),",
"for",
"a",
"portion",
"of",
"the",
"retained",
"documents.",
"the",
"retention",
"can",
"be",
"continued",
"by",
"stipulating",
"an",
"extended",
"period",
"of",
"time.",
"Article",
"4",
"(Disposal",
"Record",
"Ledger)",
"The",
"Person",
"Responsible",
"of",
"each",
"control",
"unit,",
"for",
"retained",
"documents",
"it",
"keeps,",
"shall",
"create",
"a",
"Disposal",
"Record",
"Ledger",
"in",
"accordance",
"with",
"the",
"form",
"of",
"Attachment",
"2.",
")",
"When",
"the",
"members",
"affiliated",
"in",
"this",
"Division",
"dispose",
"of",
"documents",
"for",
"which",
"the",
"retention",
"period",
"has",
"elapsed.",
"they",
"shall",
"carry",
"it",
"out",
"obtaining",
"the",
"approval",
"of",
"the",
"Person",
"Responsible",
"of",
"each",
"control",
"unit,",
"and",
"when",
"disposed",
"of,",
"shall",
"enter",
"it",
"that",
"into",
"the",
"Disposal",
"Record",
"Ledger.",
"3)",
"The",
"Person",
"Responsible",
"of",
"each",
"control",
"unit",
"shall",
"properly",
"control",
"the",
"Disposal",
"Record",
"Ledger,",
"and",
"the",
"Persons",
"In",
"Charge",
"of",
"Retention",
"shall",
"inspect",
"them",
"after",
"having",
"periodically",
"gathered",
"each",
"Disposal",
"Record",
"Ledger",
"within",
"this",
"Division,",
"and",
"when",
"necessary",
"shall",
"report",
"those",
"results",
"to",
"the",
"Person",
"Responsible",
"for",
"Retention.",
"Article",
"5",
"(Items",
"to",
"Confirm",
"At",
"the",
"Time",
"of",
"Retained",
"Document",
"Disposal)",
"EXHIBIT",
"$762823",
"v2",
"5402825",
"v2",
"PENGAD",
"200-631-5989",
"Confidential",
",",
"Briniant",
"in",
"Dratentina",
"Andar",
"TAK_DiManhe.nonnon??",
"Source:",
"https://www.indupt2377coooats.ucsf.edu/docs/xpjf0226"
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] | Which Procedures No is being decribed here? | Procedures No. 19 |
612 | [
"Top-Line",
"Summary",
"Eight",
"Regional",
"Market",
"Research",
"Consultants",
"Meetings",
"were",
"held",
"in",
"October",
"and",
"November",
"2001.",
"Each",
"location",
"featured",
"the",
"same",
"program:",
"1)",
"A",
"3-hour",
"plenary",
"session",
"featuring",
"speakers",
"and",
"Q&A;",
"and",
"2)",
"90-minute",
"breakout",
"discussion",
"sessions",
"in",
"which",
"High",
"Potential",
"TZD",
"users",
"were",
"separated",
"from",
"TZD",
"Splitters.",
"These",
"meetings",
"included",
"350",
"targeted",
"primary",
"care",
"physicians-",
"181",
"High",
"Potentials",
"and",
"169",
"TZD",
"Splitters.",
"The",
"presentations",
"strengthened",
"already-positive",
"perceptions",
"of",
"TZDs.",
"Participants",
"in",
"all",
"groups",
"agree",
"that",
"insulin",
"resistance",
"is",
"the",
"primary",
"or",
"foundational",
"defect",
"in",
"Type",
"2",
"diabetes.",
"Most",
"believe",
"intuitively",
"that",
"TZDs",
"preserve",
"beta",
"cell",
"function.",
"If",
"convinced",
"by",
"clinical",
"data",
"that",
"TZDs",
"do,",
"in",
"fact,",
"preserve",
"beta",
"cells,",
"many",
"participants",
"would",
"feel",
"compelled",
"to",
"use",
"TZDs",
"as",
"1\"-line",
"therapy.",
"There",
"is",
"broad",
"and",
"substantial",
"recognition",
"of",
"the",
"relationship",
"of",
"diabetic",
"dyslipidemia",
"and",
"cardiovascular",
"disease.",
"TZDs",
"are",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"other",
"OADs",
"on",
"most",
"concepts",
"related",
"to",
"IR",
"and",
"vascular",
"health.",
"Most",
"believe",
"that",
"TZDs",
"have",
"the",
"best",
"potential",
"for",
"a",
"positive",
"cardiovascular",
"profile.",
"Participants",
"accept",
"ACTOS",
"as",
"an",
"effective",
"and",
"liver-safe",
"agent.",
"ACTOS",
"is",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"or",
"equal",
"to",
"Avandia",
"on",
"all",
"key",
"attributes,",
"including",
"lipid",
"effects.",
"While",
"participants",
"accept",
"the",
"head-to-head",
"lipid",
"studies",
"as",
"validly-",
"conducted",
"research",
"(with",
"some",
"reservations),",
"most",
"are",
"reluctant",
"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Head-to-head",
"data",
"from",
"clinical",
"studies",
"(TZDs",
"vs.",
"other",
"OADs,",
"AND",
"ACTOS",
"vs.",
"Avandia)",
"is",
"needed",
"to",
"significantly",
"alter",
"prescribing",
"habits.",
"Splitters",
"and",
"High",
"Potentials",
"responded",
"similarly",
"with",
"regard",
"to",
"most",
"of",
"the",
"observed",
"core",
"issues,",
"although",
"Splitters",
"are",
"clearly",
"more",
"likely",
"than",
"High",
"Potentials",
"to",
"use",
"TZDs",
"as",
"first-line",
"therapy.",
"All",
"groups",
"believe",
"that",
"ACTOS",
"can",
"be",
"shown",
"to",
"be",
"valid",
"foundation",
"therapy,",
"assuming",
"the",
"accumulation",
"of",
"clinical",
"outcomes",
"data.",
"Metformin",
"is",
"an",
"effective",
"and",
"trusted",
"agent.",
"Doctors",
"caution",
"against",
"fighting",
"against",
"it",
"-",
"instead,",
"promote",
"combo",
"use",
"with",
"metformin.",
"The",
"most",
"commonly",
"mentioned",
"reasons",
"NOT",
"to",
"prescribe",
"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
"Reimbursement.",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058798",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptygacoo093ts.ucsf.edu/docs/rnjf0226"
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617 | [
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225,
982,
294,
997
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[
297,
980,
775,
997
]
] | What is Article 4 in this document referred to? | Disposal Record Ledger |
612 | [
"Top-Line",
"Summary",
"Eight",
"Regional",
"Market",
"Research",
"Consultants",
"Meetings",
"were",
"held",
"in",
"October",
"and",
"November",
"2001.",
"Each",
"location",
"featured",
"the",
"same",
"program:",
"1)",
"A",
"3-hour",
"plenary",
"session",
"featuring",
"speakers",
"and",
"Q&A;",
"and",
"2)",
"90-minute",
"breakout",
"discussion",
"sessions",
"in",
"which",
"High",
"Potential",
"TZD",
"users",
"were",
"separated",
"from",
"TZD",
"Splitters.",
"These",
"meetings",
"included",
"350",
"targeted",
"primary",
"care",
"physicians-",
"181",
"High",
"Potentials",
"and",
"169",
"TZD",
"Splitters.",
"The",
"presentations",
"strengthened",
"already-positive",
"perceptions",
"of",
"TZDs.",
"Participants",
"in",
"all",
"groups",
"agree",
"that",
"insulin",
"resistance",
"is",
"the",
"primary",
"or",
"foundational",
"defect",
"in",
"Type",
"2",
"diabetes.",
"Most",
"believe",
"intuitively",
"that",
"TZDs",
"preserve",
"beta",
"cell",
"function.",
"If",
"convinced",
"by",
"clinical",
"data",
"that",
"TZDs",
"do,",
"in",
"fact,",
"preserve",
"beta",
"cells,",
"many",
"participants",
"would",
"feel",
"compelled",
"to",
"use",
"TZDs",
"as",
"1\"-line",
"therapy.",
"There",
"is",
"broad",
"and",
"substantial",
"recognition",
"of",
"the",
"relationship",
"of",
"diabetic",
"dyslipidemia",
"and",
"cardiovascular",
"disease.",
"TZDs",
"are",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"other",
"OADs",
"on",
"most",
"concepts",
"related",
"to",
"IR",
"and",
"vascular",
"health.",
"Most",
"believe",
"that",
"TZDs",
"have",
"the",
"best",
"potential",
"for",
"a",
"positive",
"cardiovascular",
"profile.",
"Participants",
"accept",
"ACTOS",
"as",
"an",
"effective",
"and",
"liver-safe",
"agent.",
"ACTOS",
"is",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"or",
"equal",
"to",
"Avandia",
"on",
"all",
"key",
"attributes,",
"including",
"lipid",
"effects.",
"While",
"participants",
"accept",
"the",
"head-to-head",
"lipid",
"studies",
"as",
"validly-",
"conducted",
"research",
"(with",
"some",
"reservations),",
"most",
"are",
"reluctant",
"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Head-to-head",
"data",
"from",
"clinical",
"studies",
"(TZDs",
"vs.",
"other",
"OADs,",
"AND",
"ACTOS",
"vs.",
"Avandia)",
"is",
"needed",
"to",
"significantly",
"alter",
"prescribing",
"habits.",
"Splitters",
"and",
"High",
"Potentials",
"responded",
"similarly",
"with",
"regard",
"to",
"most",
"of",
"the",
"observed",
"core",
"issues,",
"although",
"Splitters",
"are",
"clearly",
"more",
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298,
980,
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] | in which month and year eight regional market research consultants meetings were held ? | October and November 2001 |
617 | [
"Translation",
"of",
"TAKJ-TPC-00000431",
"Procedures",
"Regarding",
"Document",
"Control",
"Research.",
"Div.",
"Procedures",
"No.",
"19",
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"12",
"Section",
"1",
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"Policy,",
"the",
"Person",
"In",
"Charge",
"of",
"Retention",
"shall",
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"For",
"documents",
"this",
"Division",
"retains,",
"we",
"shall",
"have",
"it",
"made",
"at",
"each",
"control",
"unit",
"in",
"accordance",
"with",
"the",
"format",
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"Attachment",
"1,",
"and",
"shall",
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"the",
"retention",
"time",
"period",
"and",
"retention",
"location",
"by",
"specific",
"type",
"of",
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"Further,",
"regardless",
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"retention",
"time",
"period",
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"when",
"it",
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"based",
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"Person",
"Responsible",
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"Retention",
"(the",
"Head",
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"Pharmaceutical",
"Research",
"Division),",
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"a",
"portion",
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"the",
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"an",
"extended",
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"Article",
"4",
"(Disposal",
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"Ledger)",
"The",
"Person",
"Responsible",
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"unit,",
"for",
"retained",
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"it",
"keeps,",
"shall",
"create",
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"Disposal",
"Record",
"Ledger",
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"the",
"form",
"of",
"Attachment",
"2.",
")",
"When",
"the",
"members",
"affiliated",
"in",
"this",
"Division",
"dispose",
"of",
"documents",
"for",
"which",
"the",
"retention",
"period",
"has",
"elapsed.",
"they",
"shall",
"carry",
"it",
"out",
"obtaining",
"the",
"approval",
"of",
"the",
"Person",
"Responsible",
"of",
"each",
"control",
"unit,",
"and",
"when",
"disposed",
"of,",
"shall",
"enter",
"it",
"that",
"into",
"the",
"Disposal",
"Record",
"Ledger.",
"3)",
"The",
"Person",
"Responsible",
"of",
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"control",
"unit",
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"properly",
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"the",
"Disposal",
"Record",
"Ledger,",
"and",
"the",
"Persons",
"In",
"Charge",
"of",
"Retention",
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"inspect",
"them",
"after",
"having",
"periodically",
"gathered",
"each",
"Disposal",
"Record",
"Ledger",
"within",
"this",
"Division,",
"and",
"when",
"necessary",
"shall",
"report",
"those",
"results",
"to",
"the",
"Person",
"Responsible",
"for",
"Retention.",
"Article",
"5",
"(Items",
"to",
"Confirm",
"At",
"the",
"Time",
"of",
"Retained",
"Document",
"Disposal)",
"EXHIBIT",
"$762823",
"v2",
"5402825",
"v2",
"PENGAD",
"200-631-5989",
"Confidential",
",",
"Briniant",
"in",
"Dratentina",
"Andar",
"TAK_DiManhe.nonnon??",
"Source:",
"https://www.indupt2377coooats.ucsf.edu/docs/xpjf0226"
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"Overall,",
"there",
"were",
"few",
"challenges",
"to",
"the",
"data",
"as",
"presented.",
"Challenges",
"included:",
"small",
"numbers",
"in",
"the",
"studies,",
"non-randomized,",
"company-",
"sponsored.",
"While",
"participants",
"accept",
"the",
"head-to-head",
"lipid",
"studies",
"as",
"validly",
"conducted",
"research",
"(with",
"the",
"caveats",
"mentioned",
"above),",
"they",
"are",
"reluctant",
"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Most",
"are",
"not",
"willing",
"to",
"base",
"their",
"decision",
"of",
"ACTOS",
"or",
"Avandia",
"on",
"these",
"data.",
".",
"In",
"certain",
"cities",
"a",
"slide",
"was",
"presented",
"showing",
"differences",
"in",
"PPAR-alpha",
"activation",
"by",
"ACTOS",
"and",
"Avandia.",
"This",
"data",
"provided",
"an",
"important",
"\"hook\"",
"for",
"participants",
"that",
"helped",
"them",
"accept",
"the",
"lipid",
"effect",
"differences.",
"Multiple",
"groups",
"noted",
"that",
"standard",
"territory",
"reps",
"may",
"not",
"be",
"trusted",
"to",
"present",
"and",
"discuss",
"detailed",
"information",
"on",
"PPAR",
"activation.",
"There",
"is",
"a",
"real",
"desire",
"for",
"clinical",
"endpoint",
"data",
"that",
"compares",
"CVD",
"endpoints",
"of",
"ACTOS",
"vs.",
"Avandia.",
"In",
"lieu",
"of",
"those",
"clinical",
"endpoint",
"data,",
"surrogates",
"would",
"include",
"those",
"listed",
"in",
"the",
"previous",
"section.",
"D.",
"Reaction",
"to",
"ACTOS",
"Foundation",
"Therapy",
"Strategy",
"All",
"groups",
"believe",
"ACTOS",
"can",
"eventually",
"capture",
"the",
"position",
"of",
"\"Foundation",
"Therapy\"",
"Participants",
"caution",
"against",
"promoting",
"against",
"metformin.",
"Instead,",
"promote",
"combination",
"therapy.",
"All",
"groups",
"believe",
"that",
"ACTOS",
"can",
"be",
"shown",
"to",
"be",
"valid",
"foundation",
"therapy,",
"with",
"clinical",
"outcomes",
"data",
"Alternative",
"terms",
"include:",
"core",
"therapy;",
"cornerstone",
"therapy;",
"first-line.",
".",
"Several",
"impediments",
"to",
"broad",
"first-line",
"use",
"were",
"mentioned:",
"edema,",
"cost,",
"reimbursement,",
"potential",
"liver",
"toxicity.",
"Several",
"groups",
"noted",
"the",
"need",
"for",
"patient",
"education",
"efforts,",
"although",
"specific",
"programs",
"were",
"not",
"defined.",
"10",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058806",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.industrygacoooquits.ucsf.edu/docs/rnjf0226"
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] | what are the challenges of ACTOS positive data? | small numbers in the studies, non-randomized, company-sponsored. |
631 | [
"NDA",
"21-073/5-023",
"Page",
"19",
"Pediatric",
"Use",
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"and",
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"U.S.",
"clinical",
"trials,",
"over",
"4700",
"patients",
"have",
"received",
"ACTOS,",
"over",
"3300",
"patients",
"have",
"been",
"treated",
"for",
"6",
"months",
"or",
"longer,",
"and",
"over",
"450",
"patients",
"for",
"one",
"year",
"or",
"longer.",
"The",
"overall",
"incidence",
"and",
"types",
"of",
"adverse",
"events",
"reported",
"in",
"placebo-controlled",
"clinical",
"trials",
"of",
"ACTOS",
"monotherapy",
"at",
"doses",
"of",
"7.5",
"mg,",
"15",
"mg,",
"30",
"mg,",
"or",
"45",
"mg",
"once",
"daily",
"are",
"shown",
"in",
"Table",
"7.",
"Table",
"7",
"Placebo-Controlled",
"Clinical",
"Studies",
"of",
"ACTOS",
"Monotherapy:",
"Adverse",
"Events",
"Reported",
"at",
"a",
"Frequency",
"2",
"5%",
"of",
"Patients",
"Treated",
"with",
"ACTOS",
"(%",
"of",
"Patients)",
"Placebo",
"ACTOS",
"V-259",
"N=606",
"Upper",
"Respiratory",
"Tract",
"Infection",
"8.5",
"13.2",
"Headache",
"6.8",
"9.1",
"Sinusitis",
"4,6",
"6.3",
"Myalgia",
"2.7",
"5.4",
"Tooth",
"Disorder",
"2.3",
"5.3",
"Diabetes",
"Mellitus",
"Aggravated",
"8.1",
"5.1",
"Pharyngitis",
"0.8",
"5.1",
"For",
"most",
"clinical",
"adverse",
"events",
"the",
"incidence",
"was",
"similar",
"for",
"groups",
"treated",
"with",
"ACTOS",
"monotherapy",
"and",
"those",
"treated",
"in",
"combination",
"with",
"sulfonylureas,",
"metformin,",
"and",
"insulin.",
"There",
"was",
"an",
"increase",
"in",
"the",
"occurrence",
"of",
"edema",
"in",
"the",
"patients",
"treated",
"with",
"ACTOS",
"and",
"insulin",
"compared",
"to",
"insulin",
"alone.",
"n",
"a",
"16-week,",
"placebo",
"controlled",
"ACTOS",
"plus",
"insulin",
"trial",
"(n=379),",
"10",
"patients",
"treated",
"with",
"ACTOS",
"plus",
"insulin",
"developed",
"dyspnea",
"and",
"also,",
"at",
"some",
"point",
"during",
"their",
"therapy,",
"developed",
"either",
"weight",
"change",
"or",
"edema.",
"Seven",
"of",
"these",
"10",
"patients",
"received",
"diuretics",
"to",
"treat",
"these",
"symptoms.",
"This",
"was",
"not",
"reported",
"in",
"the",
"insulin",
"plus",
"placebo",
"group.",
"The",
"incidence",
"of",
"withdrawals",
"from",
"placebo-controlled",
"clinical",
"trials",
"due",
"to",
"an",
"adverse",
"event",
"other",
"than",
"hyperglycemia",
"was",
"similar",
"for",
"patients",
"treated",
"with",
"placebo",
"(2.8%",
")",
"or",
"ACTOS",
"(3.3%).",
"In",
"controlled",
"combination",
"therapy",
"studies",
"with",
"either",
"a",
"sulfonylurea",
"or",
"insulin,",
"mild",
"to",
"moderate",
"hypoglycemia,",
"which",
"appears",
"to",
"be",
"dose",
"related,",
"was",
"reported",
"(see",
"PRECAUTIONS,",
"General,",
"Hypoglycemia",
"and",
"DOSAGE",
"and",
"ADMINISTRATION,",
"Combination",
"Therapy).",
"in",
"U.S.",
"double-blind",
"studies,",
"anemia",
"was",
"reported",
"in",
"$",
"2%",
"of",
"patients",
"treated",
"with",
"Hematologic).",
"ACTOS",
"plus",
"sulfonylurea,",
"metformin",
"or",
"insulin",
"(see",
"PRECAUTIONS,",
"General,",
"Source:",
"https://www.industrybeuthents.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062924"
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733,
742,
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[
780,
742,
788,
758
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[
791,
742,
810,
758
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[
115,
758,
179,
774
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[
183,
758,
243,
774
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[
141,
776,
158,
790
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[
162,
776,
242,
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246,
776,
346,
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350,
776,
412,
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[
415,
776,
475,
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478,
776,
513,
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516,
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563,
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582,
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684,
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701,
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705,
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763,
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767,
775,
801,
791
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[
805,
775,
824,
791
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[
115,
792,
192,
806
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[
196,
792,
315,
807
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[
318,
792,
366,
807
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[
370,
792,
438,
807
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[
441,
792,
457,
807
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460,
792,
483,
807
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488,
792,
527,
807
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530,
792,
593,
807
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596,
792,
631,
806
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634,
791,
703,
806
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706,
791,
744,
805
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[
115,
806,
252,
823
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256,
807,
326,
823
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330,
807,
447,
823
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451,
807,
482,
823
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[
486,
807,
565,
823
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[
569,
807,
600,
823
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[
604,
806,
771,
823
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[
116,
823,
219,
838
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[
223,
824,
302,
839
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[
141,
839,
158,
855
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[
162,
840,
201,
855
],
[
205,
840,
306,
856
],
[
310,
841,
375,
857
],
[
379,
841,
441,
857
],
[
445,
842,
479,
857
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[
483,
841,
553,
857
],
[
557,
841,
574,
857
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[
579,
841,
589,
857
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[
593,
841,
617,
857
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[
624,
841,
640,
857
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[
644,
840,
712,
857
],
[
716,
839,
774,
856
],
[
778,
838,
813,
856
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[
112,
871,
228,
889
],
[
114,
856,
178,
872
],
[
182,
857,
219,
872
],
[
223,
857,
328,
873
],
[
332,
858,
416,
873
],
[
420,
858,
437,
873
],
[
441,
858,
495,
873
],
[
499,
858,
537,
873
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[
540,
857,
680,
873
],
[
683,
856,
756,
873
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[
226,
981,
293,
997
],
[
296,
980,
775,
997
],
[
842,
974,
982,
987
]
] | In U.S. clinical trials, how many patients have received ACTOS? | over 4700 patients |
618 | [
"There",
"is",
"generally",
"broad",
"acceptance",
"of",
"the",
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"distinctions",
"between",
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"as",
"validly",
"conducted",
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"(with",
"the",
"caveats",
"mentioned",
"above),",
"they",
"are",
"reluctant",
"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Most",
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"not",
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"to",
"base",
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"of",
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"or",
"Avandia",
"on",
"these",
"data.",
".",
"In",
"certain",
"cities",
"a",
"slide",
"was",
"presented",
"showing",
"differences",
"in",
"PPAR-alpha",
"activation",
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"ACTOS",
"and",
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"provided",
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"important",
"\"hook\"",
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"participants",
"that",
"helped",
"them",
"accept",
"the",
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"effect",
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"Multiple",
"groups",
"noted",
"that",
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"territory",
"reps",
"may",
"not",
"be",
"trusted",
"to",
"present",
"and",
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"on",
"PPAR",
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"There",
"is",
"a",
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"desire",
"for",
"clinical",
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"data",
"that",
"compares",
"CVD",
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"of",
"ACTOS",
"vs.",
"Avandia.",
"In",
"lieu",
"of",
"those",
"clinical",
"endpoint",
"data,",
"surrogates",
"would",
"include",
"those",
"listed",
"in",
"the",
"previous",
"section.",
"D.",
"Reaction",
"to",
"ACTOS",
"Foundation",
"Therapy",
"Strategy",
"All",
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"believe",
"ACTOS",
"can",
"eventually",
"capture",
"the",
"position",
"of",
"\"Foundation",
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"Participants",
"caution",
"against",
"promoting",
"against",
"metformin.",
"Instead,",
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"combination",
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"All",
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"that",
"ACTOS",
"can",
"be",
"shown",
"to",
"be",
"valid",
"foundation",
"therapy,",
"with",
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"outcomes",
"data",
"Alternative",
"terms",
"include:",
"core",
"therapy;",
"cornerstone",
"therapy;",
"first-line.",
".",
"Several",
"impediments",
"to",
"broad",
"first-line",
"use",
"were",
"mentioned:",
"edema,",
"cost,",
"reimbursement,",
"potential",
"liver",
"toxicity.",
"Several",
"groups",
"noted",
"the",
"need",
"for",
"patient",
"education",
"efforts,",
"although",
"specific",
"programs",
"were",
"not",
"defined.",
"10",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058806",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.industrygacoooquits.ucsf.edu/docs/rnjf0226"
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] | What does alternate terms include? | core therapy; cornerstone therapy; first-line. |
612 | [
"Top-Line",
"Summary",
"Eight",
"Regional",
"Market",
"Research",
"Consultants",
"Meetings",
"were",
"held",
"in",
"October",
"and",
"November",
"2001.",
"Each",
"location",
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"the",
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"A",
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"and",
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"and",
"2)",
"90-minute",
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"which",
"High",
"Potential",
"TZD",
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"169",
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"resistance",
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"or",
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"that",
"TZDs",
"do,",
"in",
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"preserve",
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"many",
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"feel",
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"to",
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"as",
"1\"-line",
"therapy.",
"There",
"is",
"broad",
"and",
"substantial",
"recognition",
"of",
"the",
"relationship",
"of",
"diabetic",
"dyslipidemia",
"and",
"cardiovascular",
"disease.",
"TZDs",
"are",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"other",
"OADs",
"on",
"most",
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"related",
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"IR",
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"vascular",
"health.",
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"believe",
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"TZDs",
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"for",
"a",
"positive",
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"profile.",
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"accept",
"ACTOS",
"as",
"an",
"effective",
"and",
"liver-safe",
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"ACTOS",
"is",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"or",
"equal",
"to",
"Avandia",
"on",
"all",
"key",
"attributes,",
"including",
"lipid",
"effects.",
"While",
"participants",
"accept",
"the",
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"studies",
"as",
"validly-",
"conducted",
"research",
"(with",
"some",
"reservations),",
"most",
"are",
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"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Head-to-head",
"data",
"from",
"clinical",
"studies",
"(TZDs",
"vs.",
"other",
"OADs,",
"AND",
"ACTOS",
"vs.",
"Avandia)",
"is",
"needed",
"to",
"significantly",
"alter",
"prescribing",
"habits.",
"Splitters",
"and",
"High",
"Potentials",
"responded",
"similarly",
"with",
"regard",
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"most",
"of",
"the",
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"core",
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"although",
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"are",
"clearly",
"more",
"likely",
"than",
"High",
"Potentials",
"to",
"use",
"TZDs",
"as",
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"therapy.",
"All",
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"believe",
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"ACTOS",
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"shown",
"to",
"be",
"valid",
"foundation",
"therapy,",
"assuming",
"the",
"accumulation",
"of",
"clinical",
"outcomes",
"data.",
"Metformin",
"is",
"an",
"effective",
"and",
"trusted",
"agent.",
"Doctors",
"caution",
"against",
"fighting",
"against",
"it",
"-",
"instead,",
"promote",
"combo",
"use",
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"metformin.",
"The",
"most",
"commonly",
"mentioned",
"reasons",
"NOT",
"to",
"prescribe",
"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
"Reimbursement.",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058798",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptygacoo093ts.ucsf.edu/docs/rnjf0226"
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] | which is an effective and liver-safe agent accepted by the participants ? | ACTOS |
612 | [
"Top-Line",
"Summary",
"Eight",
"Regional",
"Market",
"Research",
"Consultants",
"Meetings",
"were",
"held",
"in",
"October",
"and",
"November",
"2001.",
"Each",
"location",
"featured",
"the",
"same",
"program:",
"1)",
"A",
"3-hour",
"plenary",
"session",
"featuring",
"speakers",
"and",
"Q&A;",
"and",
"2)",
"90-minute",
"breakout",
"discussion",
"sessions",
"in",
"which",
"High",
"Potential",
"TZD",
"users",
"were",
"separated",
"from",
"TZD",
"Splitters.",
"These",
"meetings",
"included",
"350",
"targeted",
"primary",
"care",
"physicians-",
"181",
"High",
"Potentials",
"and",
"169",
"TZD",
"Splitters.",
"The",
"presentations",
"strengthened",
"already-positive",
"perceptions",
"of",
"TZDs.",
"Participants",
"in",
"all",
"groups",
"agree",
"that",
"insulin",
"resistance",
"is",
"the",
"primary",
"or",
"foundational",
"defect",
"in",
"Type",
"2",
"diabetes.",
"Most",
"believe",
"intuitively",
"that",
"TZDs",
"preserve",
"beta",
"cell",
"function.",
"If",
"convinced",
"by",
"clinical",
"data",
"that",
"TZDs",
"do,",
"in",
"fact,",
"preserve",
"beta",
"cells,",
"many",
"participants",
"would",
"feel",
"compelled",
"to",
"use",
"TZDs",
"as",
"1\"-line",
"therapy.",
"There",
"is",
"broad",
"and",
"substantial",
"recognition",
"of",
"the",
"relationship",
"of",
"diabetic",
"dyslipidemia",
"and",
"cardiovascular",
"disease.",
"TZDs",
"are",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"other",
"OADs",
"on",
"most",
"concepts",
"related",
"to",
"IR",
"and",
"vascular",
"health.",
"Most",
"believe",
"that",
"TZDs",
"have",
"the",
"best",
"potential",
"for",
"a",
"positive",
"cardiovascular",
"profile.",
"Participants",
"accept",
"ACTOS",
"as",
"an",
"effective",
"and",
"liver-safe",
"agent.",
"ACTOS",
"is",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"or",
"equal",
"to",
"Avandia",
"on",
"all",
"key",
"attributes,",
"including",
"lipid",
"effects.",
"While",
"participants",
"accept",
"the",
"head-to-head",
"lipid",
"studies",
"as",
"validly-",
"conducted",
"research",
"(with",
"some",
"reservations),",
"most",
"are",
"reluctant",
"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Head-to-head",
"data",
"from",
"clinical",
"studies",
"(TZDs",
"vs.",
"other",
"OADs,",
"AND",
"ACTOS",
"vs.",
"Avandia)",
"is",
"needed",
"to",
"significantly",
"alter",
"prescribing",
"habits.",
"Splitters",
"and",
"High",
"Potentials",
"responded",
"similarly",
"with",
"regard",
"to",
"most",
"of",
"the",
"observed",
"core",
"issues,",
"although",
"Splitters",
"are",
"clearly",
"more",
"likely",
"than",
"High",
"Potentials",
"to",
"use",
"TZDs",
"as",
"first-line",
"therapy.",
"All",
"groups",
"believe",
"that",
"ACTOS",
"can",
"be",
"shown",
"to",
"be",
"valid",
"foundation",
"therapy,",
"assuming",
"the",
"accumulation",
"of",
"clinical",
"outcomes",
"data.",
"Metformin",
"is",
"an",
"effective",
"and",
"trusted",
"agent.",
"Doctors",
"caution",
"against",
"fighting",
"against",
"it",
"-",
"instead,",
"promote",
"combo",
"use",
"with",
"metformin.",
"The",
"most",
"commonly",
"mentioned",
"reasons",
"NOT",
"to",
"prescribe",
"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
"Reimbursement.",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058798",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptygacoo093ts.ucsf.edu/docs/rnjf0226"
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] | what is an effective and trusted agent ? | Metformin |
631 | [
"NDA",
"21-073/5-023",
"Page",
"19",
"Pediatric",
"Use",
"Safety",
"and",
"effectiveness",
"of",
"ACTOS",
"in",
"pediatric",
"patients",
"have",
"not",
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"established.",
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"Use",
"Approximately",
"500",
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"in",
"placebo-controlled",
"clinical",
"trials",
"of",
"ACTOS",
"were",
"65",
"and",
"over.",
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"significant",
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"and",
"safety",
"were",
"observed",
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"these",
"patients",
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"younger",
"patients.",
"ADVERSE",
"REACTIONS",
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"worldwide",
"clinical",
"trials,",
"over",
"6900",
"patients",
"with",
"type",
"2",
"diabetes",
"have",
"been",
"treated",
"with",
"ACTOS.",
"In",
"U.S.",
"clinical",
"trials,",
"over",
"4700",
"patients",
"have",
"received",
"ACTOS,",
"over",
"3300",
"patients",
"have",
"been",
"treated",
"for",
"6",
"months",
"or",
"longer,",
"and",
"over",
"450",
"patients",
"for",
"one",
"year",
"or",
"longer.",
"The",
"overall",
"incidence",
"and",
"types",
"of",
"adverse",
"events",
"reported",
"in",
"placebo-controlled",
"clinical",
"trials",
"of",
"ACTOS",
"monotherapy",
"at",
"doses",
"of",
"7.5",
"mg,",
"15",
"mg,",
"30",
"mg,",
"or",
"45",
"mg",
"once",
"daily",
"are",
"shown",
"in",
"Table",
"7.",
"Table",
"7",
"Placebo-Controlled",
"Clinical",
"Studies",
"of",
"ACTOS",
"Monotherapy:",
"Adverse",
"Events",
"Reported",
"at",
"a",
"Frequency",
"2",
"5%",
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"Treated",
"with",
"ACTOS",
"(%",
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"Patients)",
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"ACTOS",
"V-259",
"N=606",
"Upper",
"Respiratory",
"Tract",
"Infection",
"8.5",
"13.2",
"Headache",
"6.8",
"9.1",
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"4,6",
"6.3",
"Myalgia",
"2.7",
"5.4",
"Tooth",
"Disorder",
"2.3",
"5.3",
"Diabetes",
"Mellitus",
"Aggravated",
"8.1",
"5.1",
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"0.8",
"5.1",
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"the",
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"monotherapy",
"and",
"those",
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"in",
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"with",
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"and",
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"an",
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"of",
"edema",
"in",
"the",
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"treated",
"with",
"ACTOS",
"and",
"insulin",
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"to",
"insulin",
"alone.",
"n",
"a",
"16-week,",
"placebo",
"controlled",
"ACTOS",
"plus",
"insulin",
"trial",
"(n=379),",
"10",
"patients",
"treated",
"with",
"ACTOS",
"plus",
"insulin",
"developed",
"dyspnea",
"and",
"also,",
"at",
"some",
"point",
"during",
"their",
"therapy,",
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"either",
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"change",
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"10",
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"This",
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"not",
"reported",
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")",
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"ACTOS",
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"a",
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"insulin,",
"mild",
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"which",
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"dose",
"related,",
"was",
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"(see",
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"DOSAGE",
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"ADMINISTRATION,",
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"U.S.",
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"was",
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"in",
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"of",
"patients",
"treated",
"with",
"Hematologic).",
"ACTOS",
"plus",
"sulfonylurea,",
"metformin",
"or",
"insulin",
"(see",
"PRECAUTIONS,",
"General,",
"Source:",
"https://www.industrybeuthents.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062924"
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] | Which medicine is used for treating type 2 diabetes in over 5900 patients? | ACTOS |
612 | [
"Top-Line",
"Summary",
"Eight",
"Regional",
"Market",
"Research",
"Consultants",
"Meetings",
"were",
"held",
"in",
"October",
"and",
"November",
"2001.",
"Each",
"location",
"featured",
"the",
"same",
"program:",
"1)",
"A",
"3-hour",
"plenary",
"session",
"featuring",
"speakers",
"and",
"Q&A;",
"and",
"2)",
"90-minute",
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"discussion",
"sessions",
"in",
"which",
"High",
"Potential",
"TZD",
"users",
"were",
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"Splitters.",
"These",
"meetings",
"included",
"350",
"targeted",
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"care",
"physicians-",
"181",
"High",
"Potentials",
"and",
"169",
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"The",
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"already-positive",
"perceptions",
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"TZDs.",
"Participants",
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"agree",
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"insulin",
"resistance",
"is",
"the",
"primary",
"or",
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"defect",
"in",
"Type",
"2",
"diabetes.",
"Most",
"believe",
"intuitively",
"that",
"TZDs",
"preserve",
"beta",
"cell",
"function.",
"If",
"convinced",
"by",
"clinical",
"data",
"that",
"TZDs",
"do,",
"in",
"fact,",
"preserve",
"beta",
"cells,",
"many",
"participants",
"would",
"feel",
"compelled",
"to",
"use",
"TZDs",
"as",
"1\"-line",
"therapy.",
"There",
"is",
"broad",
"and",
"substantial",
"recognition",
"of",
"the",
"relationship",
"of",
"diabetic",
"dyslipidemia",
"and",
"cardiovascular",
"disease.",
"TZDs",
"are",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"other",
"OADs",
"on",
"most",
"concepts",
"related",
"to",
"IR",
"and",
"vascular",
"health.",
"Most",
"believe",
"that",
"TZDs",
"have",
"the",
"best",
"potential",
"for",
"a",
"positive",
"cardiovascular",
"profile.",
"Participants",
"accept",
"ACTOS",
"as",
"an",
"effective",
"and",
"liver-safe",
"agent.",
"ACTOS",
"is",
"currently",
"perceived",
"to",
"be",
"better",
"than",
"or",
"equal",
"to",
"Avandia",
"on",
"all",
"key",
"attributes,",
"including",
"lipid",
"effects.",
"While",
"participants",
"accept",
"the",
"head-to-head",
"lipid",
"studies",
"as",
"validly-",
"conducted",
"research",
"(with",
"some",
"reservations),",
"most",
"are",
"reluctant",
"to",
"attach",
"a",
"great",
"deal",
"of",
"clinical",
"value",
"to",
"the",
"data.",
"Head-to-head",
"data",
"from",
"clinical",
"studies",
"(TZDs",
"vs.",
"other",
"OADs,",
"AND",
"ACTOS",
"vs.",
"Avandia)",
"is",
"needed",
"to",
"significantly",
"alter",
"prescribing",
"habits.",
"Splitters",
"and",
"High",
"Potentials",
"responded",
"similarly",
"with",
"regard",
"to",
"most",
"of",
"the",
"observed",
"core",
"issues,",
"although",
"Splitters",
"are",
"clearly",
"more",
"likely",
"than",
"High",
"Potentials",
"to",
"use",
"TZDs",
"as",
"first-line",
"therapy.",
"All",
"groups",
"believe",
"that",
"ACTOS",
"can",
"be",
"shown",
"to",
"be",
"valid",
"foundation",
"therapy,",
"assuming",
"the",
"accumulation",
"of",
"clinical",
"outcomes",
"data.",
"Metformin",
"is",
"an",
"effective",
"and",
"trusted",
"agent.",
"Doctors",
"caution",
"against",
"fighting",
"against",
"it",
"-",
"instead,",
"promote",
"combo",
"use",
"with",
"metformin.",
"The",
"most",
"commonly",
"mentioned",
"reasons",
"NOT",
"to",
"prescribe",
"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
"Reimbursement.",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058798",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptygacoo093ts.ucsf.edu/docs/rnjf0226"
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".0,1",
"0.0",
"0.6",
"Difference",
"from",
"placebo",
"(adjusted",
"mean*)",
"1.0",
"-0.9",
"14",
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"(mg/dL)",
"N=54",
"N=53",
"N=58",
"N=56",
"Screening",
"(mean)",
"222",
"209",
"230",
"215",
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"(mean)",
"285",
"275",
"286",
"292",
"Change",
"from",
"baseline",
"(adjusted",
"mean*)",
"-32",
"-27",
"-56",
"Difference",
"from",
"placebo",
"(adjusted",
"mean*)",
"-36",
"-31",
"59",
"Adjusted",
"for",
"baseline",
"and",
"pooled",
"canter",
"In",
"a",
"24-week",
"placebo-controlled",
"study,",
"260",
"patients",
"with",
"type",
"2",
"diabetes",
"were",
"randomized",
"to",
"one",
"of",
"two",
"forced-titration",
"ACTOS",
"treatment",
"groups",
"or",
"a",
"mock",
"titration",
"placebo",
"group",
"Therapy",
"with",
"any",
"previous",
"antidiabetic",
"agent",
"was",
"discontinued",
"6",
"weeks",
"prior",
"to",
"the",
"double-",
"blind",
"period.",
"In",
"one",
"ACTOS",
"treatment",
"group,",
"patients",
"received",
"an",
"initial",
"dose",
"of",
"7.5",
"mg",
"once",
"daily.",
"After",
"four",
"weeks,",
"the",
"dose",
"was",
"increased",
"to",
"15",
"mg",
"once",
"daily",
"and",
"after",
"another",
"four",
"weeks,",
"the",
"dose",
"was",
"increased",
"to",
"30",
"mg",
"once",
"daily",
"for",
"the",
"remainder",
"of",
"the",
"study",
"(16",
"weeks).",
"In",
"the",
"second",
"ACTOS",
"treatment",
"group,",
"patients",
"received",
"an",
"initial",
"dose",
"of",
"15",
"mg",
"once",
"daily",
"and",
"were",
"titrated",
"to",
"30",
"mg",
"once",
"daily",
"and",
"45",
"mg",
"once",
"daily",
"in",
"a",
"similar",
"manner.",
"Treatment",
"with",
"ACTOS,",
"as",
"described,",
"produced",
"statistically",
"significant",
"improvements",
"in",
"HbAjc",
"and",
"FPG",
"at",
"endpoint",
"compared",
"to",
"placebo",
"(see",
"Table",
"4).",
"Source:",
"https://www.indusR716020908",
"trydocuments.ucsf.edu/docs/hfkf0226",
"PLA-TAK-00062915"
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] | in a 24 week placebo controlled study how many patients with type 2 diabetes were randomized ? | 260 patients |
625 | [
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] | What is the retention time period of contracts? | Permanently |
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] | What is the date mentioned in this document? | March 2017 |
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] | What is the exhibit number? | 39 |
667 | [
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295,
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]
] | Roger Johnson is associated with which union? | National Farmers Union |
667 | [
"CEO",
"Council",
"Members",
"American",
"Farm",
"Bureau",
"Vincent",
"\"Zippy\"",
"Duvall,",
"President",
"American",
"Seed",
"Trade",
"Association",
"Andrew",
"\"Andy\"",
"LaVigne,",
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"and",
"CEO",
"American",
"Soybean",
"Association",
"Steve",
"Censky,",
"Chief",
"Executive",
"Officer",
"(Co-Chair)",
"Biotechnology",
"Innovation",
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"Dana",
"O'Brien,",
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"America",
"Jay",
"Vroom,",
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"and",
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"(Co-Chair)",
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"Chris",
"Jahn,",
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"Association",
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"Chandler",
"Goule,",
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"Association",
"Kendal",
"Frazier,",
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"National",
"Chicken",
"Council",
"Michael",
"Brown,",
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"National",
"Corn",
"Growers",
"Association",
"Chris",
"Novak,",
"CEO",
"(Co-Chair)",
"National",
"Cotton",
"Council",
"Gary",
"Adams,",
"President",
"and",
"CEO",
"National",
"Council",
"of",
"Farmer",
"Cooperatives",
"Chuck",
"Conner,",
"President",
"and",
"CEO",
"National",
"Farmers",
"Union",
"Roger",
"Johnson,",
"President",
"National",
"Milk",
"Producers",
"Federation",
"Jim",
"Mulhern,",
"President",
"and",
"CEO",
"National",
"Pork",
"Producers",
"Council",
"Neil",
"Dierks,",
"CEO",
"United",
"Fresh",
"Produce",
"Association",
"Tom",
"Stenzel,",
"President",
"and",
"CEO",
"USA",
"Rice",
"Federation",
"Betsy",
"Ward,",
"President",
"&",
"CEO",
"National",
"Association",
"of",
"State",
"Departments",
"of",
"Barb",
"Glenn,",
"CEO,",
"ex-officio",
"Agriculture",
"March",
"2017",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/ffcn0225_001225_00000062-00003"
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] | What is the title of this document? | CEO Council Members |
630 | [
"Specific",
"Findings",
"A.",
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"accept",
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"1)",
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"random",
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"is",
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"convinced",
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"that",
"TZDs",
"do,",
"in",
"fact,",
"preserve",
"beta",
"cell",
"function,",
"many",
"(perhaps",
"most)",
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"would",
"feel",
"compelled",
"to",
"use",
"TZDs",
"as",
"first",
"line",
"therapy.",
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"believe",
"intuitively",
"that",
"TZDs",
"preserve",
"beta",
"cells.",
".",
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"all",
"groups,",
"the",
"most",
"commonly",
"mentioned",
"reasons",
"NOT",
"to",
"prescribe",
"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
"Reimbursement.",
"In",
"Dallas",
"and",
"Miami,",
"Steve",
"Crow",
"asked",
"his",
"High",
"Potential",
"groups",
"\"If",
"a",
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"accepts",
"IR",
"as",
"the",
"core",
"defect,",
"and",
"agrees",
"that",
"TZDs",
"directly",
"address",
"IR,",
"what",
"would",
"preclude",
"the",
"use",
"of",
"TZDs",
"as",
"primary",
"mono/combo",
"therapy?\"",
"Responses",
"included,",
"in",
"no",
"particular",
"order:",
"8",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058804",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptrygacoooogts.ucsf.edu/docs/rnjf0226"
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] | What is accepted as an effective glucose control agent? | ACTOS |
630 | [
"Specific",
"Findings",
"A.",
"Reaction",
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"accept",
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"1)",
"Cost,",
"2)",
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"do,",
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"line",
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".",
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"mentioned",
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"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
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"In",
"Dallas",
"and",
"Miami,",
"Steve",
"Crow",
"asked",
"his",
"High",
"Potential",
"groups",
"\"If",
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"IR",
"as",
"the",
"core",
"defect,",
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"agrees",
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"TZDs",
"directly",
"address",
"IR,",
"what",
"would",
"preclude",
"the",
"use",
"of",
"TZDs",
"as",
"primary",
"mono/combo",
"therapy?\"",
"Responses",
"included,",
"in",
"no",
"particular",
"order:",
"8",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058804",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptrygacoooogts.ucsf.edu/docs/rnjf0226"
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] | what are reasons not to prescribe TZDs ? | 1)cost,2)edema/weight gain, and 3) reimbursement |
630 | [
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"Findings",
"A.",
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"1)",
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"2)",
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".",
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"TZDs",
"are",
"1)",
"Cost,",
"2)",
"Edema/weight",
"gain,",
"and",
"3)",
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"In",
"Dallas",
"and",
"Miami,",
"Steve",
"Crow",
"asked",
"his",
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"\"If",
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"IR,",
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"would",
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"the",
"use",
"of",
"TZDs",
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"primary",
"mono/combo",
"therapy?\"",
"Responses",
"included,",
"in",
"no",
"particular",
"order:",
"8",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-DALYRI-00058804",
"Produced",
"in",
"MDL",
"on",
"09/17/12",
"Source:",
"https://www.induptrygacoooogts.ucsf.edu/docs/rnjf0226"
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] | By whom was this document prepared? | C. Beck, LLC |
639 | [
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316,
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] | When was the rule PROPOSED? | Jan. 19, 2017 |
645 | [
"Toxicology",
"Education",
"Foundation",
"page",
"2",
"-",
"Proposal",
"to",
"3M",
"from",
"the",
"Toxicology",
"Education",
"Foundation",
"(TEF)",
"Toxicology",
"Education",
"Foundation",
"F.O.",
"Box",
"98224",
"ESTIMATED",
"DATE",
"OF",
"COMPLETION:",
"It",
"is",
"TEF's",
"intention",
"to",
"upload",
"a",
"Raleigh,",
"NO",
"27624",
"Korean",
"version",
"of",
"Is",
"It",
"Safe?",
"by",
"September",
"30,",
"2017.",
"The",
"parties",
"acknowledging",
"this",
"agreement",
"below",
"recognize",
"that",
"meeting",
"this",
"target",
"date",
"is",
"dependent",
"upon",
"consensus",
"about",
"the",
"timeline",
"and",
"cooperation",
"of",
"all",
"parties",
"involved.",
"TEF",
"will",
"do",
"everything",
"reasonable",
"to",
"keep",
"all",
"parties",
"involved",
"on",
"schedule.",
"2017-2018",
"Board",
"of",
"Trustees",
"DISCLAIMER:",
"IN",
"NO",
"EVENT",
"WILL",
"3M",
"BE",
"LIABLE",
"TO",
"TEF",
"OR",
"ANY",
"THIRD",
"PARTY",
"FOR",
"ANY",
"DIRECT,",
"INDIRECT,",
"INCIDENTAL,",
"SPECIAL",
"OR",
"President",
"Stickael",
"Dourson,",
"Ph.D.,",
"DABT",
"CONSEQUENTIAL",
"DAMAGES",
"FOR",
"THE",
"KOREAN",
"VERSION",
"\"IS",
"IT",
"SAFE\"",
"University",
"of",
"Clushumans",
"VIDEO",
"INCLUDING,",
"BUT",
"NOT",
"LIMITED",
"TO,",
"DAMAGES",
"ARISING",
"FROM",
"Vice",
"President",
"William",
"Farland,",
"PID,",
"ATS",
"LOSS",
"OF",
"PROFITS,",
"BUSINESS",
"INTERRUPTION,",
"OR",
"LOSS",
"OF",
"DATA,",
"Colorado",
"State",
"University",
"EVEN",
"IF",
"3M",
"IS",
"EXPRESSLY",
"ADVISED",
"ABOUT",
"THE",
"POSSIBILITY",
"OF",
"Secretary!",
"Treasurer",
"SUCH",
"DAMAGES,",
"TO",
"THE",
"FULLEST",
"EXTENT",
"ALLOWABLE",
"BY",
"LAW.",
"Tony",
"Ndifor,",
"Ph.D.",
"Johnson",
"&",
"Johnson",
"Trustees",
"The",
"undersigned",
"agree",
"to",
"all",
"terms",
"of",
"this",
"proposal.",
"Nancy",
"Deck,",
"Ph.D.,",
"DABT",
"American",
"Chemistry",
"Council",
"Silvia",
"Berlang's",
"de",
"Marses",
"Barros,",
"MSc.,",
"Ph.D.",
"University",
"of",
"Sao",
"Park",
"For",
"3M:",
"David",
"Cragin,",
"Ph.D.,",
"DABT",
"Merck",
"And",
"de",
"Poyster,",
"Ph.D.,",
"ATS",
"James",
"Zappia,",
"Manager",
"San",
"Diego",
"State",
"University",
"(Emeritus)",
"Toxicology",
"and",
"Compliance",
"Solutions,",
"3M",
"Medical",
"Department",
"John",
"DeSesso,",
"Ph.D.,",
"ATS",
"Exponent",
"Date:",
"Suzanne",
"C.",
"Fitzpatrick,",
"Ph.D.,",
"DART",
"U.S.",
"Food",
"and",
"Drug",
"Administration",
"Jay",
"W.",
"Gooch,",
"Ph.",
"D.",
"Riffles",
"&",
"Pools",
"Commimications,",
"LLC",
"Mark",
"Lafranconi,",
"Ph.D.,",
"DART",
"ox.Horizons",
"For",
"TEF:",
"Gladys",
"Ouedraogo,",
"Ph.D.",
"L'oreal",
"Anthony",
"Ndifor,",
"TEF",
"Secretary/Treasurer",
"Richard",
"D.",
"Phillips,",
"Ph.",
"D.",
"ExxonMobil",
"(retired",
"Date:_",
"July",
"20th",
"20it",
"Nicole",
"Soucy,",
"PAD.",
"DABT",
"David",
"Steup,",
"Ph.D.,",
"DABT",
"Shell",
"(retired)",
"Philip",
"Wexler,",
"BS,",
"MLS",
"National",
"Library",
"of",
"Medicine",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/nfcn0226"
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] | What is the name of the FOUNDATION this PROPOSAL belongs to? | Toxicology Education Foundation |
645 | [
"Toxicology",
"Education",
"Foundation",
"page",
"2",
"-",
"Proposal",
"to",
"3M",
"from",
"the",
"Toxicology",
"Education",
"Foundation",
"(TEF)",
"Toxicology",
"Education",
"Foundation",
"F.O.",
"Box",
"98224",
"ESTIMATED",
"DATE",
"OF",
"COMPLETION:",
"It",
"is",
"TEF's",
"intention",
"to",
"upload",
"a",
"Raleigh,",
"NO",
"27624",
"Korean",
"version",
"of",
"Is",
"It",
"Safe?",
"by",
"September",
"30,",
"2017.",
"The",
"parties",
"acknowledging",
"this",
"agreement",
"below",
"recognize",
"that",
"meeting",
"this",
"target",
"date",
"is",
"dependent",
"upon",
"consensus",
"about",
"the",
"timeline",
"and",
"cooperation",
"of",
"all",
"parties",
"involved.",
"TEF",
"will",
"do",
"everything",
"reasonable",
"to",
"keep",
"all",
"parties",
"involved",
"on",
"schedule.",
"2017-2018",
"Board",
"of",
"Trustees",
"DISCLAIMER:",
"IN",
"NO",
"EVENT",
"WILL",
"3M",
"BE",
"LIABLE",
"TO",
"TEF",
"OR",
"ANY",
"THIRD",
"PARTY",
"FOR",
"ANY",
"DIRECT,",
"INDIRECT,",
"INCIDENTAL,",
"SPECIAL",
"OR",
"President",
"Stickael",
"Dourson,",
"Ph.D.,",
"DABT",
"CONSEQUENTIAL",
"DAMAGES",
"FOR",
"THE",
"KOREAN",
"VERSION",
"\"IS",
"IT",
"SAFE\"",
"University",
"of",
"Clushumans",
"VIDEO",
"INCLUDING,",
"BUT",
"NOT",
"LIMITED",
"TO,",
"DAMAGES",
"ARISING",
"FROM",
"Vice",
"President",
"William",
"Farland,",
"PID,",
"ATS",
"LOSS",
"OF",
"PROFITS,",
"BUSINESS",
"INTERRUPTION,",
"OR",
"LOSS",
"OF",
"DATA,",
"Colorado",
"State",
"University",
"EVEN",
"IF",
"3M",
"IS",
"EXPRESSLY",
"ADVISED",
"ABOUT",
"THE",
"POSSIBILITY",
"OF",
"Secretary!",
"Treasurer",
"SUCH",
"DAMAGES,",
"TO",
"THE",
"FULLEST",
"EXTENT",
"ALLOWABLE",
"BY",
"LAW.",
"Tony",
"Ndifor,",
"Ph.D.",
"Johnson",
"&",
"Johnson",
"Trustees",
"The",
"undersigned",
"agree",
"to",
"all",
"terms",
"of",
"this",
"proposal.",
"Nancy",
"Deck,",
"Ph.D.,",
"DABT",
"American",
"Chemistry",
"Council",
"Silvia",
"Berlang's",
"de",
"Marses",
"Barros,",
"MSc.,",
"Ph.D.",
"University",
"of",
"Sao",
"Park",
"For",
"3M:",
"David",
"Cragin,",
"Ph.D.,",
"DABT",
"Merck",
"And",
"de",
"Poyster,",
"Ph.D.,",
"ATS",
"James",
"Zappia,",
"Manager",
"San",
"Diego",
"State",
"University",
"(Emeritus)",
"Toxicology",
"and",
"Compliance",
"Solutions,",
"3M",
"Medical",
"Department",
"John",
"DeSesso,",
"Ph.D.,",
"ATS",
"Exponent",
"Date:",
"Suzanne",
"C.",
"Fitzpatrick,",
"Ph.D.,",
"DART",
"U.S.",
"Food",
"and",
"Drug",
"Administration",
"Jay",
"W.",
"Gooch,",
"Ph.",
"D.",
"Riffles",
"&",
"Pools",
"Commimications,",
"LLC",
"Mark",
"Lafranconi,",
"Ph.D.,",
"DART",
"ox.Horizons",
"For",
"TEF:",
"Gladys",
"Ouedraogo,",
"Ph.D.",
"L'oreal",
"Anthony",
"Ndifor,",
"TEF",
"Secretary/Treasurer",
"Richard",
"D.",
"Phillips,",
"Ph.",
"D.",
"ExxonMobil",
"(retired",
"Date:_",
"July",
"20th",
"20it",
"Nicole",
"Soucy,",
"PAD.",
"DABT",
"David",
"Steup,",
"Ph.D.,",
"DABT",
"Shell",
"(retired)",
"Philip",
"Wexler,",
"BS,",
"MLS",
"National",
"Library",
"of",
"Medicine",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/nfcn0226"
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] | Who is the vice president of this FOUNDATION? | William Farland, PhD, ATS |
645 | [
"Toxicology",
"Education",
"Foundation",
"page",
"2",
"-",
"Proposal",
"to",
"3M",
"from",
"the",
"Toxicology",
"Education",
"Foundation",
"(TEF)",
"Toxicology",
"Education",
"Foundation",
"F.O.",
"Box",
"98224",
"ESTIMATED",
"DATE",
"OF",
"COMPLETION:",
"It",
"is",
"TEF's",
"intention",
"to",
"upload",
"a",
"Raleigh,",
"NO",
"27624",
"Korean",
"version",
"of",
"Is",
"It",
"Safe?",
"by",
"September",
"30,",
"2017.",
"The",
"parties",
"acknowledging",
"this",
"agreement",
"below",
"recognize",
"that",
"meeting",
"this",
"target",
"date",
"is",
"dependent",
"upon",
"consensus",
"about",
"the",
"timeline",
"and",
"cooperation",
"of",
"all",
"parties",
"involved.",
"TEF",
"will",
"do",
"everything",
"reasonable",
"to",
"keep",
"all",
"parties",
"involved",
"on",
"schedule.",
"2017-2018",
"Board",
"of",
"Trustees",
"DISCLAIMER:",
"IN",
"NO",
"EVENT",
"WILL",
"3M",
"BE",
"LIABLE",
"TO",
"TEF",
"OR",
"ANY",
"THIRD",
"PARTY",
"FOR",
"ANY",
"DIRECT,",
"INDIRECT,",
"INCIDENTAL,",
"SPECIAL",
"OR",
"President",
"Stickael",
"Dourson,",
"Ph.D.,",
"DABT",
"CONSEQUENTIAL",
"DAMAGES",
"FOR",
"THE",
"KOREAN",
"VERSION",
"\"IS",
"IT",
"SAFE\"",
"University",
"of",
"Clushumans",
"VIDEO",
"INCLUDING,",
"BUT",
"NOT",
"LIMITED",
"TO,",
"DAMAGES",
"ARISING",
"FROM",
"Vice",
"President",
"William",
"Farland,",
"PID,",
"ATS",
"LOSS",
"OF",
"PROFITS,",
"BUSINESS",
"INTERRUPTION,",
"OR",
"LOSS",
"OF",
"DATA,",
"Colorado",
"State",
"University",
"EVEN",
"IF",
"3M",
"IS",
"EXPRESSLY",
"ADVISED",
"ABOUT",
"THE",
"POSSIBILITY",
"OF",
"Secretary!",
"Treasurer",
"SUCH",
"DAMAGES,",
"TO",
"THE",
"FULLEST",
"EXTENT",
"ALLOWABLE",
"BY",
"LAW.",
"Tony",
"Ndifor,",
"Ph.D.",
"Johnson",
"&",
"Johnson",
"Trustees",
"The",
"undersigned",
"agree",
"to",
"all",
"terms",
"of",
"this",
"proposal.",
"Nancy",
"Deck,",
"Ph.D.,",
"DABT",
"American",
"Chemistry",
"Council",
"Silvia",
"Berlang's",
"de",
"Marses",
"Barros,",
"MSc.,",
"Ph.D.",
"University",
"of",
"Sao",
"Park",
"For",
"3M:",
"David",
"Cragin,",
"Ph.D.,",
"DABT",
"Merck",
"And",
"de",
"Poyster,",
"Ph.D.,",
"ATS",
"James",
"Zappia,",
"Manager",
"San",
"Diego",
"State",
"University",
"(Emeritus)",
"Toxicology",
"and",
"Compliance",
"Solutions,",
"3M",
"Medical",
"Department",
"John",
"DeSesso,",
"Ph.D.,",
"ATS",
"Exponent",
"Date:",
"Suzanne",
"C.",
"Fitzpatrick,",
"Ph.D.,",
"DART",
"U.S.",
"Food",
"and",
"Drug",
"Administration",
"Jay",
"W.",
"Gooch,",
"Ph.",
"D.",
"Riffles",
"&",
"Pools",
"Commimications,",
"LLC",
"Mark",
"Lafranconi,",
"Ph.D.,",
"DART",
"ox.Horizons",
"For",
"TEF:",
"Gladys",
"Ouedraogo,",
"Ph.D.",
"L'oreal",
"Anthony",
"Ndifor,",
"TEF",
"Secretary/Treasurer",
"Richard",
"D.",
"Phillips,",
"Ph.",
"D.",
"ExxonMobil",
"(retired",
"Date:_",
"July",
"20th",
"20it",
"Nicole",
"Soucy,",
"PAD.",
"DABT",
"David",
"Steup,",
"Ph.D.,",
"DABT",
"Shell",
"(retired)",
"Philip",
"Wexler,",
"BS,",
"MLS",
"National",
"Library",
"of",
"Medicine",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/nfcn0226"
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] | What is the date mentioned at the bottom? | July 20th 2017 |
643 | [
"The",
"Fertilizer",
"Institute",
"Nourish,",
"Replenish,",
"Grow",
"BIOGRAPHY",
"OF",
"CHRISTOPHER",
"JAHN",
"President",
"The",
"Fertilizer",
"Institute",
"and",
"the",
"Nutrients",
"for",
"Life",
"Foundation",
"Christopher",
"L.",
"Jahn",
"is",
"president",
"of",
"The",
"Fertilizer",
"Institute",
"(TFI),",
"the",
"fertilizer",
"industry's",
"national",
"trade",
"association.",
"As",
"TFI",
"president,",
"Jahn",
"works",
"to",
"represent,",
"promote",
"and",
"protect",
"a",
"sound",
"fertilizer",
"industry",
"through",
"legislative",
"and",
"regulatory",
"activities",
"and",
"to",
"promote",
"a",
"favorable",
"public",
"image",
"of",
"the",
"fertilizer",
"industry",
"and",
"agriculture.",
"Jahn",
"also",
"serves",
"as",
"president",
"of",
"the",
"Nutrients",
"for",
"Life",
"Foundation",
"(NFL).",
"Jahn",
"comes",
"to",
"TFI",
"having",
"served",
"as",
"president",
"of",
"the",
"National",
"Association",
"of",
"Chemical",
"Distributors",
"(NACD)",
"since",
"2006.",
"Prior",
"to",
"leading",
"NACD,",
"Jahn",
"served",
"as",
"president",
"of",
"the",
"Contract",
"Services",
"Association",
"(CSA).",
"Before",
"joining",
"CSA,",
"Jahn",
"had",
"an",
"active",
"role",
"in",
"the",
"United",
"States",
"Senate",
"working",
"for",
"nearly",
"10",
"years",
"for",
"U.S.",
"Senator",
"Craig",
"Thomas",
"(R-Wyo.)",
"in",
"a",
"variety",
"of",
"roles,",
"including",
"legislative",
"assistant,",
"legislative",
"director",
"and",
"Chief",
"of",
"Staff.",
"After",
"graduating",
"from",
"Columbia",
"University",
"with",
"a",
"B.A.",
"in",
"Political",
"Science,",
"Jahn",
"co-founded",
"a",
"book",
"distribution",
"business.",
"He",
"also",
"earned",
"an",
"MBA",
"from",
"the",
"University",
"of",
"Maryland.",
"A",
"native",
"of",
"Wyoming,",
"Chris",
"and",
"his",
"wife,",
"Ex.",
"6",
"-",
"Personal",
"Privacy",
"Ex.",
"6",
"-",
"Personal",
"Privacy",
"Capitol",
"View",
"202.962.0490",
"425",
"Third",
"Street,",
"S.",
"W.,",
"Suite",
"950",
"202.962.0577",
"fax",
"Washington,",
"DC",
"20024",
"www.tfi.org",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/ffcn0225_001225_00000062-00012"
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296,
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] | Whose biography is this? | Christopher Jahn |
643 | [
"The",
"Fertilizer",
"Institute",
"Nourish,",
"Replenish,",
"Grow",
"BIOGRAPHY",
"OF",
"CHRISTOPHER",
"JAHN",
"President",
"The",
"Fertilizer",
"Institute",
"and",
"the",
"Nutrients",
"for",
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] | For how many years did Christopher Jahn work for U.S. Senator Craig Thomas? | 10 |
643 | [
"The",
"Fertilizer",
"Institute",
"Nourish,",
"Replenish,",
"Grow",
"BIOGRAPHY",
"OF",
"CHRISTOPHER",
"JAHN",
"President",
"The",
"Fertilizer",
"Institute",
"and",
"the",
"Nutrients",
"for",
"Life",
"Foundation",
"Christopher",
"L.",
"Jahn",
"is",
"president",
"of",
"The",
"Fertilizer",
"Institute",
"(TFI),",
"the",
"fertilizer",
"industry's",
"national",
"trade",
"association.",
"As",
"TFI",
"president,",
"Jahn",
"works",
"to",
"represent,",
"promote",
"and",
"protect",
"a",
"sound",
"fertilizer",
"industry",
"through",
"legislative",
"and",
"regulatory",
"activities",
"and",
"to",
"promote",
"a",
"favorable",
"public",
"image",
"of",
"the",
"fertilizer",
"industry",
"and",
"agriculture.",
"Jahn",
"also",
"serves",
"as",
"president",
"of",
"the",
"Nutrients",
"for",
"Life",
"Foundation",
"(NFL).",
"Jahn",
"comes",
"to",
"TFI",
"having",
"served",
"as",
"president",
"of",
"the",
"National",
"Association",
"of",
"Chemical",
"Distributors",
"(NACD)",
"since",
"2006.",
"Prior",
"to",
"leading",
"NACD,",
"Jahn",
"served",
"as",
"president",
"of",
"the",
"Contract",
"Services",
"Association",
"(CSA).",
"Before",
"joining",
"CSA,",
"Jahn",
"had",
"an",
"active",
"role",
"in",
"the",
"United",
"States",
"Senate",
"working",
"for",
"nearly",
"10",
"years",
"for",
"U.S.",
"Senator",
"Craig",
"Thomas",
"(R-Wyo.)",
"in",
"a",
"variety",
"of",
"roles,",
"including",
"legislative",
"assistant,",
"legislative",
"director",
"and",
"Chief",
"of",
"Staff.",
"After",
"graduating",
"from",
"Columbia",
"University",
"with",
"a",
"B.A.",
"in",
"Political",
"Science,",
"Jahn",
"co-founded",
"a",
"book",
"distribution",
"business.",
"He",
"also",
"earned",
"an",
"MBA",
"from",
"the",
"University",
"of",
"Maryland.",
"A",
"native",
"of",
"Wyoming,",
"Chris",
"and",
"his",
"wife,",
"Ex.",
"6",
"-",
"Personal",
"Privacy",
"Ex.",
"6",
"-",
"Personal",
"Privacy",
"Capitol",
"View",
"202.962.0490",
"425",
"Third",
"Street,",
"S.",
"W.,",
"Suite",
"950",
"202.962.0577",
"fax",
"Washington,",
"DC",
"20024",
"www.tfi.org",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/ffcn0225_001225_00000062-00012"
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641 | [
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640 | [
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"States",
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] | what is in the appendix A? | mode of action analysis for liver tumors based on NCI slide reread and Rfd derivation (Dourson et al. 2014) |
646 | [
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] | What is the name of the President of BOARD OF TRUSTEES? | Michael Leonard Dourson |
646 | [
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"2016",
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"C.",
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"Sciences,",
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"University",
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"Liaison",
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"H.",
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"ATS,",
"Website",
"Content",
"Philip",
"Wexler,",
"BS,",
"MLS",
"Colorado",
"State",
"University",
"National",
"Library",
"of",
"Medicine",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/jgcn0226"
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294,
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] | To which university did William H. Farland belong to? | Colorado State University |
642 | [
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"offers",
"a",
"one",
"week",
"turnaround,",
"depending",
"upon",
"availability.",
"12",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/mxcn0226"
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218,
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285,
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854,
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218,
981,
285,
997
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288,
980,
785,
997
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] | What is the heading of the budget table? | For 5 Test Articles - Phase IB (definitive) |
647 | [
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319,
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322,
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] | What is the heading of the document? | Thank You |
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322,
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] | Who are the Publication co-authors? | Michael Dourson, Bernard Gadagbui, John Lowe and Rod Thompson |
650 | [
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"Fire",
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"Ormond,",
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"919-524-1569",
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"Telephone:",
"+1.617.984.7281",
"Fax:",
"+1.617.984.7010",
"Email:",
"Foundation",
"@NFPA.org",
"www.NFPA.org/foundation",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/hlcn0226"
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223,
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291,
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[
294,
980,
779,
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] | what is the full form of ppe? | Personal Protective Equipment |
650 | [
"RESEARCH",
"FOUNDATION",
"NFPA",
"RESEARCH",
"FOR",
"THE",
"NFPA",
"MISSION",
"PPE",
"Cleaning",
"Validation",
"Validation",
"of",
"Cleaning",
"Procedures",
"for",
"Fire",
"Fighter",
"Personal",
"Protective",
"Equipment",
"(PPE)",
"PROJECT",
"CONTACTS",
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"Updated:",
"22",
"May",
"2017",
"Project",
"Technical",
"Panel",
"David",
"Bernzweig,",
"Columbus",
"Fire",
"Department",
"(OH)",
"Phone:",
"614-774-7446",
"Email:",
"Safety",
"@local67.com",
"Ken",
"Block,",
"Edmonton",
"Fire/Rescue",
"&",
"Metro",
"Chiefs",
"Representative",
":",
"780-496-3801",
"mail:",
"ken.block",
"@edmonton.ca",
"Ken",
"Brown,",
"VA",
"State",
"Firefighter's",
"Association",
"&",
"NVFC",
"(Alt",
"to",
"B.",
"McQueen)",
"Phone:",
"804-971-7983",
"Email;",
"kbrownret@aol.com",
"Roger",
"Curtis,",
"ECMS",
"Curtis",
"&",
"Sons",
"(CA)",
"Phone:",
"510-839-5111",
"Cell:",
"213-321-9393",
"mail:",
"rcurtis@incurtis.com",
"Paul",
"Curtis,",
"ECMS",
"Curtis",
"&",
"Sons",
"(CA)",
"(Alt",
"to",
"Roger",
"Curtis)",
"Phon",
"Email:",
"pcurtis@incurtis.com",
"Steve",
"Lakey,",
"Northwest",
"Safety",
"Clean",
"(WA)",
"Phone:",
"253-277-4131",
"Cell:",
"503-314-4832",
"Email:",
"Steve@northwestsafetyclean.com",
"Mark",
"Lambert,",
"WV",
"Fire",
"Academy",
"&",
"NAFTD",
"(WV)",
"Phone:",
"304-406-7479",
"Email:",
"mlambe",
"13",
"@mail.wvu.edu",
"Ed",
"Mccarthy,",
"Boston",
"Fire",
"Department",
"(MA)",
"Phone:",
"617-828-3978",
"Email:",
"Edward.mccarthy@boston.gov",
"Brian",
"McQueen,",
"FASNY",
"&",
"National",
"Volunteer",
"Fire",
"Council",
"(NY)",
"Phone:",
"315-736-7479",
"Cell:",
"315-552-8245",
"Email:",
"fasnydirector@gmail.com",
"Mark",
"Miller,",
"Phoenix",
"Fire",
"Dept.",
"(AZ)",
"Phone:",
"602-5",
"Email:",
"mark.a.miller@phoenix.gov",
"Bryan",
"Ormond,",
"NCSU",
"(NC)",
"Phone:",
"919-524-1569",
"Email:",
"rbormond",
"@ncsu.edu",
"Russ",
"Osgood,",
"Firefighter",
"Cancer",
"Support",
"Network",
"(NH)",
"(Alt",
"to",
"Keith",
"Tyson)",
"Phone",
"Email:",
"rosgood@fcsn.net",
"Larry",
"Petrick,",
"IAFF",
"(DC)",
"Phone",
"Email:",
"LPetrick@iaff.org",
"Jim",
"Riley,",
"Boston",
"Fire",
"Department",
"(MA)",
"(Alt",
"to",
"E.",
"Mccarthy)",
"Phone:",
"617-549-9850",
"Email:",
"james.riley",
"@boston.gov",
"Molly",
"Riley,",
"Virginia",
"Beach",
"Fire",
"Dept.",
"(VA)",
"Phone:",
"757-385-2892",
"mail:",
"mriley@vbgov.com",
"Thomas",
"Smith,",
"FDNY",
"(NY)",
"Phone:",
"718-999-2922",
"Email:",
"Thomas.Smith",
"@fany.nyc.gov",
"Tim",
"Tomlinson,",
"Gear",
"Cleaning",
"Solutions",
"(TX)",
"Phone:",
"214-774-2213",
"Cell:",
"940-300-5718",
"mail:",
"tim",
"@gearcleaningsolutions.com",
"Robert",
"Tutterow,",
"NFPA",
"Fire",
"Serv",
"Fire",
"Service",
"Section",
"(NC)",
"Phone",
"Email:",
"ratutterow",
"@gmail.com",
"Keith",
"Tyson,",
"Firefighter",
"Cancer",
"Support",
"Network",
"(FL)",
"Phone:",
"786-351-3276",
"Email:",
"KTyson",
"@FCSN.net",
"Dick",
"Weise,",
"LA",
"County",
"Fire",
"Dept.",
"(CA)",
"Phone:",
"95",
"1-",
"Email:",
"rweiselacofd@yahoo.com",
"Ken",
"Wiles,",
"LA",
"County",
"Fire",
"Dept.",
"(CA)",
"(Alt",
"to",
"Dick",
"Weiss)",
"Phone:",
"949-291-0637",
"Email:",
"Ken.",
"Wiles",
"@fire.lacounty.gov",
"Chris",
"Youngblood,",
"Austin",
"Fire",
"Dept.",
"(TX)",
"Phone:",
"512-974-0286",
"Email:",
"Christopher.",
"Youngblood@austintexas.gov",
"1",
"Batterymarch",
"Park,",
"Quincy,",
"MA",
"02169-7471",
"Telephone:",
"+1.617.984.7281",
"Fax:",
"+1.617.984.7010",
"Email:",
"Foundation",
"@NFPA.org",
"www.NFPA.org/foundation",
"Source:",
"https://www.industrydocuments.ucsf.edu/docs/hlcn0226"
] | [
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] | what is the subtitle for research foundation? | Research for the NFPA Mission |