id
string | words
sequence | boxes
sequence | question
string | answer
string |
|---|---|---|---|---|
539 | [
"Actos",
"Pediatric",
"Working",
"Group",
"Date:",
"20",
"April",
"2006",
"Time:",
"4:00pm",
"-",
"5:00pm",
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"403",
"Attendees",
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"Alfonso",
"Perez",
"-",
"Clinical",
"Karen",
"Kaluzny",
"-",
"Project",
"Management",
"X",
"Stuart",
"Kupfer",
"-",
"Clinica",
"X",
"Mary",
"Jo",
"Pritza",
"-",
"Regulatory",
"X",
"Brigit",
"Isaacson",
"-",
"Clinical",
"X",
"Shari",
"Bodnoff",
"-",
"Medical",
"Writing",
"X",
"Pat",
"Schwartz",
"-",
"Clinical",
"Andy",
"Roberts",
"-",
"Medical",
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"X",
"Mondira",
"Bhattacharya",
"-",
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"Safety",
"X",
"Agenda",
"Items",
"GDC",
"Update",
"TPC",
"stressed",
"the",
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"ACTOS",
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"and",
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"that",
"the",
"preparation",
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"the",
"written",
"request",
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"Next",
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"-",
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"Clinical",
"Hold",
"Removal",
"Request",
"Document",
"A",
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"will",
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"scheduled",
"in",
"early",
"May",
"to",
"develop",
"the",
"overall",
"structure",
"of",
"the",
"document.",
"In",
"addition",
"to",
"the",
"elements",
"already",
"defined,",
"the",
"team",
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"the",
"following",
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"new",
"nonclinical",
"data",
"regarding",
"PPAR",
"agonists",
"and",
"bladder",
"safety",
"Bladder",
"safety",
"analysis",
"from",
"CHICAGO",
"study",
"(Projected",
"database",
"lock:",
"5",
"June",
"2006)",
"Post-meeting",
"note:",
"Additional",
"safety",
"analysis",
"from",
"ACTOS",
"506",
"study",
"Action",
"Items:",
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"will",
"forward",
"article",
"regarding",
"rosiglitazone",
"and",
"nonclinical",
"bladder",
"data",
"to",
"Andy.",
"Andy",
"will",
"request",
"a",
"literature",
"search",
"for",
"any",
"new",
"articles",
"regarding",
"PPARs",
"and",
"nonclinical",
"bladder",
"data.",
"Mary",
"Jo",
"will",
"follow-up",
"with",
"David",
"Baron",
"to",
"determine",
"if",
"he",
"is",
"aware",
"of",
"any",
"new",
"data",
"regarding",
"PPARs",
"and",
"bladder",
"safety.",
"Mary",
"Jo",
"will",
"determine",
"if",
"the",
"FDA",
"has",
"received",
"information",
"about",
"the",
"PROactive",
"extension",
"and",
"the",
"second",
"KNPC",
"study",
"being",
"done",
"to",
"fulfill",
"EMEA's",
"requirements.",
"Post-meeting",
"note:",
"Completed.",
"Both",
"protocols",
"were",
"sent",
"to",
"the",
"FDA.",
"Andy",
"will",
"follow-up",
"with",
"Regulatory",
"to",
"obtain",
"examples",
"of",
"other",
"clinical",
"hold",
"removal",
"request",
"documents.",
"(Deb",
"Yarbrough",
"-",
"TAK-428,",
"Mary",
"Jo",
"-",
"TAK-654)",
"Karen",
"will",
"schedule",
"the",
"document",
"development",
"meeting",
"for",
"the",
"second",
"week",
"of",
"May.",
"N:/Product",
"Development",
"and",
"Planning/ACTOS/Working",
"Groups/Pediatrics/<AUTO>",
"Page",
"1",
"of",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-KUPFES-00716752",
"Produced",
"in",
"MDL",
"on",
"09/19/12",
"Source:",
"https://www.indup4885-ooounits.ucsf.edu/docs/nqjf0226"
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] | what is the place mentioned ? | Meeting Room 403 |
543 | [
"Ms.",
"Wakamatsu,",
"Assistant",
"manager,",
"Dept.",
"Strategic",
"Development,",
"et",
"al.",
"Attachment:",
"NDA",
"schedule",
"for",
"each",
"project",
"approved",
"on",
"the",
"5th",
"GDC",
"1.",
"Openings",
"Remarks",
"Dr.",
"Kitazawa",
"made",
"opening",
"remarks.",
"He",
"mentioned",
"that",
"TAKEDA",
"has",
"been",
"driving",
"for",
"to",
"be",
"a",
"global",
"pharmaceutical",
"company",
"in",
"this",
"decade,",
"concentrating",
"all",
"resource",
"into",
"the",
"pharmaceutical",
"business,",
"under",
"the",
"clear-cut",
"leadership",
"of",
"the",
"CEO.",
"Pharmaceutical",
"Development",
"Division",
"is",
"a",
"core",
"organization",
"of",
"Takeda",
"Pharmaceutical",
"Company,",
"enhancing",
"the",
"pipeline",
"products,",
"which",
"is",
"the",
"decisive",
"factor",
"for",
"TAKEDA",
"business.",
"However,",
"in",
"the",
"present",
"condition,",
"since",
"the",
"launch",
"of",
"Actos",
"in",
"1999",
"there",
"are",
"no",
"new",
"products",
"launched.",
"While",
"this",
"situation",
"is",
"critical,",
"the",
"Pharmaceutical",
"Development",
"Division",
"is",
"thought",
"to",
"be",
"conservative",
"and",
"lack",
"of",
"challenging",
"spirit.",
"He",
"stated",
"that",
"his",
"mission",
"is",
"to",
"improve",
"this",
"conservative",
"atmosphere",
"and",
"grow",
"challenging",
"spirit",
"to",
"develop",
"and",
"launch",
"the",
"new",
"products",
"earlier",
"than",
"scheduled.",
"Formatted:",
"Not",
"Hidden",
"3.",
"MPDRAP-I",
"(Diabetes)",
"1)",
"AD-4833",
"Update",
"of",
"US",
"status",
"by",
"TPNA",
"Bladder",
"tumor",
"observed",
"in",
"NN622",
"study",
"As",
"for",
"the",
"bladder",
"issues,",
"an",
"expected",
"response",
"from",
"FDA",
"is",
"in",
"early",
"October",
"and",
"pediatric",
"study",
"(Actos",
"508)",
"is",
"temporarily",
"on",
"hold,",
"however,",
"this",
"is",
"not",
"an",
"official",
"hold.",
"In",
"the",
"recent",
"teleconference",
"discussing",
"non-clinical",
"issues,",
"the",
"experts",
"could",
"not",
"identify",
"any",
"rational",
"hypothesis",
"that",
"dual",
"PPAR",
"agonists",
"may",
"be",
"linked",
"to",
"bladder",
"tumogenesis.",
"A",
"clinical",
"expert",
"meeting",
"is",
"scheduled",
"for",
"October",
"1",
"and",
"2",
"to",
"discuss",
"how",
"to",
"screen/monitor",
"bladder",
"tumors",
"in",
"long-term",
"clinical",
"trials,",
"since",
"FDA",
"may",
"force",
"TPNA",
"to",
"do",
"it.",
"Label",
"changes",
"may",
"be",
"requested",
"by",
"FDA",
"and",
"it",
"is",
"very",
"difficult",
"to",
"assess",
"the",
"marketing",
"impact",
"of",
"such",
"label",
"change",
"at",
"this",
"moment.",
"It",
"was",
"suggested",
"to",
"prepare",
"non-clinical",
"\"White",
"paper\"",
"to",
"address",
"the",
"bladder",
"issue.",
"US",
"commitment",
"study",
"of",
"30mg",
"vs.",
"45mg",
"An",
"SNDA",
"will",
"be",
"submitted",
"in",
"this",
"autumn,",
"where",
"studies",
"341,",
"342,",
"343",
"and",
"513",
"are",
"included.",
"The",
"objectives",
"of",
"the",
"submission",
"are",
"for",
"1)",
"a",
"safety",
"purpose,",
"not",
"for",
"an",
"efficacy",
"or",
"new",
"indication",
"of",
"45mg,",
"and",
"2)",
"an",
"update",
"of",
"oral",
"contraceptive",
"interaction",
"results",
"in",
"the",
"label.",
"Timelines",
"and",
"issues",
"on",
"Actos",
"combination",
"projects",
"were",
"presented.",
"Actos-Metformin",
"Convenience",
"Pack",
"is",
"expected",
"to",
"file",
"sNDA",
"in",
"March",
"2003",
"and",
"to",
"be",
"approved",
"in",
"September",
"2003.",
"TPNA",
"believes",
"stability",
"data",
"of",
"3",
"months",
"are",
"sufficient",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-THOMCL-00012574",
"Source:",
"https://www.indupto442coo02ts.ucsf.edu/docs/Imjf0226",
"Produced",
"in",
"MDL",
"on",
"09/14/12"
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539 | [
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] | What date is the meeting scheduled to develop the overall structure of the document? | in early May |
540 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"4",
"of",
"4",
"Highlights",
"from",
"Cohen",
"Hypothesis",
"Discussion",
">",
"Philip",
"Collett",
"presented",
"an",
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"the",
"Cohen",
"hypothesis",
"Male",
"rat",
"urine",
"has",
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"high",
"protein",
"content,",
"which",
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"a",
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"sex",
"hormones",
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"the",
"pH",
"of",
"male",
"rat",
"urine",
"above",
"6.5",
"is",
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"the",
"development",
"of",
"calculi",
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"rats",
"are",
"quadropeds,",
"they",
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"do",
"The",
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"in",
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"paper",
"is",
"0.61.",
"The",
"European",
"authorities",
"initially",
"determined",
"this",
"to",
"be",
"quite",
"low;",
"however,",
"Dr.",
"Cohen",
"authored",
"an",
"expert",
"report",
"which",
"stated",
"that",
"the",
"0.61",
"correlation",
"was",
"actually",
"high,",
"as",
"calculi",
"can",
"dissolve",
"over",
"time.",
"In",
"summary,",
"the",
"tumors",
"seen",
"in",
"rats",
"were",
"due",
"to",
"the",
"presence",
"of",
"calculi.",
"The",
"male",
"rat",
"urine",
"milieu",
"contributes",
"to",
"the",
"formation",
"of",
"calculi.",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"bipeds",
"do.",
"Main",
"Points",
"from",
"Takeda",
"Europe",
"Experience",
"Takeda",
"Europe",
"successfully",
"employed",
"the",
"following",
"strategy:",
"Defended",
"Cohen",
"hypothesis,",
"despite",
"numerous",
"challenges",
"Stressed",
"the",
"\"one",
"sex,",
"one",
"species\"",
"argument",
"Challenged",
"authorities",
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"plan",
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"to",
"conduct",
"a",
"case",
"control",
"study",
"post-approval",
"Highlights",
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"Agonist",
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"address",
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"issues",
"in",
"the",
"initial",
"FDA",
"response.",
"However,",
"it",
"was",
"decided",
"that",
"this",
"argument",
"should",
"be",
"developed,",
"as",
"it",
"may",
"be",
"necessary",
"to",
"use",
"it",
"in",
"the",
"future,",
"and",
"action",
"items",
"were",
"assigned",
"accordingly.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487176",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indug2/pg-00604s.ucsf.edu/docs/myjf0226"
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] | Who presented an outline of the Cohen hypothesis? | Philip Collett |
540 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"4",
"of",
"4",
"Highlights",
"from",
"Cohen",
"Hypothesis",
"Discussion",
">",
"Philip",
"Collett",
"presented",
"an",
"outline",
"of",
"the",
"Cohen",
"hypothesis",
"Male",
"rat",
"urine",
"has",
"a",
"very",
"high",
"protein",
"content,",
"which",
"is",
"a",
"function",
"of",
"sex",
"hormones",
"Raising",
"the",
"pH",
"of",
"male",
"rat",
"urine",
"above",
"6.5",
"is",
"significant",
"in",
"the",
"development",
"of",
"calculi",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"humans",
"do",
"The",
"correlation",
"observed",
"in",
"Cohen's",
"paper",
"is",
"0.61.",
"The",
"European",
"authorities",
"initially",
"determined",
"this",
"to",
"be",
"quite",
"low;",
"however,",
"Dr.",
"Cohen",
"authored",
"an",
"expert",
"report",
"which",
"stated",
"that",
"the",
"0.61",
"correlation",
"was",
"actually",
"high,",
"as",
"calculi",
"can",
"dissolve",
"over",
"time.",
"In",
"summary,",
"the",
"tumors",
"seen",
"in",
"rats",
"were",
"due",
"to",
"the",
"presence",
"of",
"calculi.",
"The",
"male",
"rat",
"urine",
"milieu",
"contributes",
"to",
"the",
"formation",
"of",
"calculi.",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"bipeds",
"do.",
"Main",
"Points",
"from",
"Takeda",
"Europe",
"Experience",
"Takeda",
"Europe",
"successfully",
"employed",
"the",
"following",
"strategy:",
"Defended",
"Cohen",
"hypothesis,",
"despite",
"numerous",
"challenges",
"Stressed",
"the",
"\"one",
"sex,",
"one",
"species\"",
"argument",
"Challenged",
"authorities",
"regarding",
"implementing",
"monitoring",
"plan",
"Offered",
"to",
"conduct",
"a",
"case",
"control",
"study",
"post-approval",
"Highlights",
"from",
"PPAR",
"Agonist",
"Discussion",
"The",
"group",
"extensively",
"discussed",
"many",
"aspects",
"of",
"the",
"PPAR",
"mechanism",
"and",
"ultimately",
"decided",
"to",
"not",
"address",
"mechanistic",
"issues",
"in",
"the",
"initial",
"FDA",
"response.",
"However,",
"it",
"was",
"decided",
"that",
"this",
"argument",
"should",
"be",
"developed,",
"as",
"it",
"may",
"be",
"necessary",
"to",
"use",
"it",
"in",
"the",
"future,",
"and",
"action",
"items",
"were",
"assigned",
"accordingly.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487176",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indug2/pg-00604s.ucsf.edu/docs/myjf0226"
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] | What is significant in the development of calculi? | Raising the pH of male rat urine above 6.5 |
540 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"4",
"of",
"4",
"Highlights",
"from",
"Cohen",
"Hypothesis",
"Discussion",
">",
"Philip",
"Collett",
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"rat",
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"has",
"a",
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"high",
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"content,",
"which",
"is",
"a",
"function",
"of",
"sex",
"hormones",
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"the",
"pH",
"of",
"male",
"rat",
"urine",
"above",
"6.5",
"is",
"significant",
"in",
"the",
"development",
"of",
"calculi",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"humans",
"do",
"The",
"correlation",
"observed",
"in",
"Cohen's",
"paper",
"is",
"0.61.",
"The",
"European",
"authorities",
"initially",
"determined",
"this",
"to",
"be",
"quite",
"low;",
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"report",
"which",
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"the",
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"rats",
"were",
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"the",
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"rat",
"urine",
"milieu",
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"rats",
"are",
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"they",
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"Main",
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"Europe",
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"one",
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"argument",
"should",
"be",
"developed,",
"as",
"it",
"may",
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"and",
"action",
"items",
"were",
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"-",
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"to",
"Protective",
"Order",
"TAK-RAMSTM-00487176",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indug2/pg-00604s.ucsf.edu/docs/myjf0226"
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997
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] | What is the correlation observed in cohen's paper? | 0.61 |
540 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"4",
"of",
"4",
"Highlights",
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"Cohen",
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"Discussion",
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"Collett",
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"pH",
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"male",
"rat",
"urine",
"above",
"6.5",
"is",
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"in",
"the",
"development",
"of",
"calculi",
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"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"humans",
"do",
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"to",
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"quite",
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547 | [
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"on",
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"Source:",
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] | Which forum is mentioned in this document? | Takeda Global Risk Management Forum |
542 | [
"107",
"FDA",
"Conference",
"Call:",
"August",
"13,",
"2002",
"PENGAD",
"800-631-698",
"EXHIBIT",
"FDA",
"Personnel:",
"Jeri",
"El-Hage,",
"Ph.D.,",
"Toxicology",
"Team",
"Leader",
"Jena",
"Weber,",
"Project",
"Manager",
"TPNA",
"Personnel:",
"David",
"Baron,",
"Ph.D.,",
"Director,",
"Nonclinical",
"Safety",
"and",
"Efficacy",
"Janet",
"Haskins,",
"Manager,",
"Regulatory",
"Affairs",
"Pat",
"Frank,",
"Ph.D.,",
"TPNA",
"Consultant",
"This",
"teleconference",
"was",
"held",
"as",
"a",
"follow-up",
"to",
"a",
"discussion",
"between",
"TPNA",
"and",
"the",
"Agency",
"on",
"July",
"31,",
"2002.",
"The",
"purpose",
"of",
"this",
"call",
"was",
"so",
"that",
"Dr.",
"El-Hage",
"could",
"expand",
"upon",
"the",
"nonclinical",
"data",
"related",
"to",
"dual",
"PPAR",
"agonists",
"that",
"were",
"discussed",
"with",
"TPNA",
"on",
"July",
"31,",
"2002.",
"Dr.",
"El-Hage",
"informed",
"TPNA",
"that",
"in",
"standard",
"2-year",
"rat",
"and",
"mouse",
"bioassay",
"studies,",
"several",
"other",
"dual",
"PPAR",
"agonists",
"were",
"shown",
"to",
"cause",
"transitional",
"cell",
"tumors",
"in",
"the",
"bladder",
"and",
"kidneys",
"of",
"male",
"and",
"female",
"rats",
"and",
"male",
"mice.",
"Therefore,",
"the",
"Division",
"is",
"considering",
"the",
"relevance",
"of",
"these",
"findings",
"to",
"this",
"pharmaceutical",
"class",
"of",
"drugs.",
"She",
"also",
"noted",
"that",
"in",
"follow-up",
"unspecified",
"mechanistic",
"studies",
"of",
"the",
"other",
"dual",
"PPAR",
"agonists,",
"no",
"evidence",
"of",
"irritation",
"by",
"crystalluria",
"or",
"calculi",
"was",
"noted.",
"Dr.",
"El-Hage",
"then",
"described",
"a",
"tumor",
"promoter-model",
"study",
"that",
"was",
"conducted",
"by",
"another",
"sponsor",
"in",
"which",
"pioglitazone",
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"The",
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"was",
"designed",
"as",
"follows:",
".",
"BBN",
"was",
"given",
"to",
"male",
"Fisher",
"rats",
"in",
"their",
"drinking",
"water",
"for",
"four",
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"Four",
"groups",
"were",
"designated:",
".",
"Pioglitazone",
"40",
"mg/kg/day",
"after",
"BBN",
"The",
"study",
"compound",
"plus",
"BBN",
"(No",
"dosages",
"were",
"specified,",
"but",
"Dr.",
"El-Hage",
"noted",
"that",
"multiple",
"dosages",
"were",
"studied",
"and",
"the",
"high",
"dose",
"was",
"designed",
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"\"equivalent\"",
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"40",
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")",
"The",
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"group",
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"BBN",
"only.",
".",
"The",
"positive",
"control",
"group",
"received",
"uracil.",
"Duration",
"of",
"daily",
"dosing",
"was",
"32-weeks",
"after",
"BBN.",
"Results:",
".",
"85%",
"of",
"the",
"animals",
"in",
"the",
"pioglitazone",
"and",
"the",
"other",
"sponsor's",
"compound",
"groups",
"had",
"tumor",
"formation.",
"Calculi",
"formation",
"was",
"not",
"confirmed",
"in",
"either",
"group,",
"but",
"was",
"looked",
"for",
"using",
"unspecified",
"methodology",
"15%",
"of",
"the",
"animals",
"in",
"the",
"negative",
"control",
"group",
"had",
"tumor",
"formation,",
"while",
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"50%",
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"control",
"group",
"presented",
"tumors",
"in",
"the",
"presence",
"of",
"calculi",
"formation",
"(uracil).",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-NAUGHP-00080811",
"Source:",
"https://www.indup53720boots.ucsf.edu/docs/jsjf0226"
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] | What is the issued date of this document? | august 13, 2002 |
542 | [
"107",
"FDA",
"Conference",
"Call:",
"August",
"13,",
"2002",
"PENGAD",
"800-631-698",
"EXHIBIT",
"FDA",
"Personnel:",
"Jeri",
"El-Hage,",
"Ph.D.,",
"Toxicology",
"Team",
"Leader",
"Jena",
"Weber,",
"Project",
"Manager",
"TPNA",
"Personnel:",
"David",
"Baron,",
"Ph.D.,",
"Director,",
"Nonclinical",
"Safety",
"and",
"Efficacy",
"Janet",
"Haskins,",
"Manager,",
"Regulatory",
"Affairs",
"Pat",
"Frank,",
"Ph.D.,",
"TPNA",
"Consultant",
"This",
"teleconference",
"was",
"held",
"as",
"a",
"follow-up",
"to",
"a",
"discussion",
"between",
"TPNA",
"and",
"the",
"Agency",
"on",
"July",
"31,",
"2002.",
"The",
"purpose",
"of",
"this",
"call",
"was",
"so",
"that",
"Dr.",
"El-Hage",
"could",
"expand",
"upon",
"the",
"nonclinical",
"data",
"related",
"to",
"dual",
"PPAR",
"agonists",
"that",
"were",
"discussed",
"with",
"TPNA",
"on",
"July",
"31,",
"2002.",
"Dr.",
"El-Hage",
"informed",
"TPNA",
"that",
"in",
"standard",
"2-year",
"rat",
"and",
"mouse",
"bioassay",
"studies,",
"several",
"other",
"dual",
"PPAR",
"agonists",
"were",
"shown",
"to",
"cause",
"transitional",
"cell",
"tumors",
"in",
"the",
"bladder",
"and",
"kidneys",
"of",
"male",
"and",
"female",
"rats",
"and",
"male",
"mice.",
"Therefore,",
"the",
"Division",
"is",
"considering",
"the",
"relevance",
"of",
"these",
"findings",
"to",
"this",
"pharmaceutical",
"class",
"of",
"drugs.",
"She",
"also",
"noted",
"that",
"in",
"follow-up",
"unspecified",
"mechanistic",
"studies",
"of",
"the",
"other",
"dual",
"PPAR",
"agonists,",
"no",
"evidence",
"of",
"irritation",
"by",
"crystalluria",
"or",
"calculi",
"was",
"noted.",
"Dr.",
"El-Hage",
"then",
"described",
"a",
"tumor",
"promoter-model",
"study",
"that",
"was",
"conducted",
"by",
"another",
"sponsor",
"in",
"which",
"pioglitazone",
"was",
"administered.",
"The",
"study",
"was",
"designed",
"as",
"follows:",
".",
"BBN",
"was",
"given",
"to",
"male",
"Fisher",
"rats",
"in",
"their",
"drinking",
"water",
"for",
"four",
"weeks.",
"Four",
"groups",
"were",
"designated:",
".",
"Pioglitazone",
"40",
"mg/kg/day",
"after",
"BBN",
"The",
"study",
"compound",
"plus",
"BBN",
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"85%",
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"the",
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"(uracil).",
"Confidential",
"-",
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"TAK-NAUGHP-00080811",
"Source:",
"https://www.indup53720boots.ucsf.edu/docs/jsjf0226"
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300,
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] | Who is the Director of Nonclinical Safety and Efficacy? | David baron |
542 | [
"107",
"FDA",
"Conference",
"Call:",
"August",
"13,",
"2002",
"PENGAD",
"800-631-698",
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"Personnel:",
"Jeri",
"El-Hage,",
"Ph.D.,",
"Toxicology",
"Team",
"Leader",
"Jena",
"Weber,",
"Project",
"Manager",
"TPNA",
"Personnel:",
"David",
"Baron,",
"Ph.D.,",
"Director,",
"Nonclinical",
"Safety",
"and",
"Efficacy",
"Janet",
"Haskins,",
"Manager,",
"Regulatory",
"Affairs",
"Pat",
"Frank,",
"Ph.D.,",
"TPNA",
"Consultant",
"This",
"teleconference",
"was",
"held",
"as",
"a",
"follow-up",
"to",
"a",
"discussion",
"between",
"TPNA",
"and",
"the",
"Agency",
"on",
"July",
"31,",
"2002.",
"The",
"purpose",
"of",
"this",
"call",
"was",
"so",
"that",
"Dr.",
"El-Hage",
"could",
"expand",
"upon",
"the",
"nonclinical",
"data",
"related",
"to",
"dual",
"PPAR",
"agonists",
"that",
"were",
"discussed",
"with",
"TPNA",
"on",
"July",
"31,",
"2002.",
"Dr.",
"El-Hage",
"informed",
"TPNA",
"that",
"in",
"standard",
"2-year",
"rat",
"and",
"mouse",
"bioassay",
"studies,",
"several",
"other",
"dual",
"PPAR",
"agonists",
"were",
"shown",
"to",
"cause",
"transitional",
"cell",
"tumors",
"in",
"the",
"bladder",
"and",
"kidneys",
"of",
"male",
"and",
"female",
"rats",
"and",
"male",
"mice.",
"Therefore,",
"the",
"Division",
"is",
"considering",
"the",
"relevance",
"of",
"these",
"findings",
"to",
"this",
"pharmaceutical",
"class",
"of",
"drugs.",
"She",
"also",
"noted",
"that",
"in",
"follow-up",
"unspecified",
"mechanistic",
"studies",
"of",
"the",
"other",
"dual",
"PPAR",
"agonists,",
"no",
"evidence",
"of",
"irritation",
"by",
"crystalluria",
"or",
"calculi",
"was",
"noted.",
"Dr.",
"El-Hage",
"then",
"described",
"a",
"tumor",
"promoter-model",
"study",
"that",
"was",
"conducted",
"by",
"another",
"sponsor",
"in",
"which",
"pioglitazone",
"was",
"administered.",
"The",
"study",
"was",
"designed",
"as",
"follows:",
".",
"BBN",
"was",
"given",
"to",
"male",
"Fisher",
"rats",
"in",
"their",
"drinking",
"water",
"for",
"four",
"weeks.",
"Four",
"groups",
"were",
"designated:",
".",
"Pioglitazone",
"40",
"mg/kg/day",
"after",
"BBN",
"The",
"study",
"compound",
"plus",
"BBN",
"(No",
"dosages",
"were",
"specified,",
"but",
"Dr.",
"El-Hage",
"noted",
"that",
"multiple",
"dosages",
"were",
"studied",
"and",
"the",
"high",
"dose",
"was",
"designed",
"to",
"be",
"\"equivalent\"",
"to",
"40",
"mg/kg",
"pioglitazone",
")",
"The",
"negative",
"control",
"group",
"received",
"BBN",
"only.",
".",
"The",
"positive",
"control",
"group",
"received",
"uracil.",
"Duration",
"of",
"daily",
"dosing",
"was",
"32-weeks",
"after",
"BBN.",
"Results:",
".",
"85%",
"of",
"the",
"animals",
"in",
"the",
"pioglitazone",
"and",
"the",
"other",
"sponsor's",
"compound",
"groups",
"had",
"tumor",
"formation.",
"Calculi",
"formation",
"was",
"not",
"confirmed",
"in",
"either",
"group,",
"but",
"was",
"looked",
"for",
"using",
"unspecified",
"methodology",
"15%",
"of",
"the",
"animals",
"in",
"the",
"negative",
"control",
"group",
"had",
"tumor",
"formation,",
"while",
"approximately",
"50%",
"of",
"the",
"positive",
"control",
"group",
"presented",
"tumors",
"in",
"the",
"presence",
"of",
"calculi",
"formation",
"(uracil).",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-NAUGHP-00080811",
"Source:",
"https://www.indup53720boots.ucsf.edu/docs/jsjf0226"
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] | Who described tumor promoter-model study? | dr. el-hage |
542 | [
"107",
"FDA",
"Conference",
"Call:",
"August",
"13,",
"2002",
"PENGAD",
"800-631-698",
"EXHIBIT",
"FDA",
"Personnel:",
"Jeri",
"El-Hage,",
"Ph.D.,",
"Toxicology",
"Team",
"Leader",
"Jena",
"Weber,",
"Project",
"Manager",
"TPNA",
"Personnel:",
"David",
"Baron,",
"Ph.D.,",
"Director,",
"Nonclinical",
"Safety",
"and",
"Efficacy",
"Janet",
"Haskins,",
"Manager,",
"Regulatory",
"Affairs",
"Pat",
"Frank,",
"Ph.D.,",
"TPNA",
"Consultant",
"This",
"teleconference",
"was",
"held",
"as",
"a",
"follow-up",
"to",
"a",
"discussion",
"between",
"TPNA",
"and",
"the",
"Agency",
"on",
"July",
"31,",
"2002.",
"The",
"purpose",
"of",
"this",
"call",
"was",
"so",
"that",
"Dr.",
"El-Hage",
"could",
"expand",
"upon",
"the",
"nonclinical",
"data",
"related",
"to",
"dual",
"PPAR",
"agonists",
"that",
"were",
"discussed",
"with",
"TPNA",
"on",
"July",
"31,",
"2002.",
"Dr.",
"El-Hage",
"informed",
"TPNA",
"that",
"in",
"standard",
"2-year",
"rat",
"and",
"mouse",
"bioassay",
"studies,",
"several",
"other",
"dual",
"PPAR",
"agonists",
"were",
"shown",
"to",
"cause",
"transitional",
"cell",
"tumors",
"in",
"the",
"bladder",
"and",
"kidneys",
"of",
"male",
"and",
"female",
"rats",
"and",
"male",
"mice.",
"Therefore,",
"the",
"Division",
"is",
"considering",
"the",
"relevance",
"of",
"these",
"findings",
"to",
"this",
"pharmaceutical",
"class",
"of",
"drugs.",
"She",
"also",
"noted",
"that",
"in",
"follow-up",
"unspecified",
"mechanistic",
"studies",
"of",
"the",
"other",
"dual",
"PPAR",
"agonists,",
"no",
"evidence",
"of",
"irritation",
"by",
"crystalluria",
"or",
"calculi",
"was",
"noted.",
"Dr.",
"El-Hage",
"then",
"described",
"a",
"tumor",
"promoter-model",
"study",
"that",
"was",
"conducted",
"by",
"another",
"sponsor",
"in",
"which",
"pioglitazone",
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"was",
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"as",
"follows:",
".",
"BBN",
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"male",
"Fisher",
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"in",
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"water",
"for",
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"Four",
"groups",
"were",
"designated:",
".",
"Pioglitazone",
"40",
"mg/kg/day",
"after",
"BBN",
"The",
"study",
"compound",
"plus",
"BBN",
"(No",
"dosages",
"were",
"specified,",
"but",
"Dr.",
"El-Hage",
"noted",
"that",
"multiple",
"dosages",
"were",
"studied",
"and",
"the",
"high",
"dose",
"was",
"designed",
"to",
"be",
"\"equivalent\"",
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"40",
"mg/kg",
"pioglitazone",
")",
"The",
"negative",
"control",
"group",
"received",
"BBN",
"only.",
".",
"The",
"positive",
"control",
"group",
"received",
"uracil.",
"Duration",
"of",
"daily",
"dosing",
"was",
"32-weeks",
"after",
"BBN.",
"Results:",
".",
"85%",
"of",
"the",
"animals",
"in",
"the",
"pioglitazone",
"and",
"the",
"other",
"sponsor's",
"compound",
"groups",
"had",
"tumor",
"formation.",
"Calculi",
"formation",
"was",
"not",
"confirmed",
"in",
"either",
"group,",
"but",
"was",
"looked",
"for",
"using",
"unspecified",
"methodology",
"15%",
"of",
"the",
"animals",
"in",
"the",
"negative",
"control",
"group",
"had",
"tumor",
"formation,",
"while",
"approximately",
"50%",
"of",
"the",
"positive",
"control",
"group",
"presented",
"tumors",
"in",
"the",
"presence",
"of",
"calculi",
"formation",
"(uracil).",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-NAUGHP-00080811",
"Source:",
"https://www.indup53720boots.ucsf.edu/docs/jsjf0226"
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] | What is the duration of daily dosing? | 32-weeks |
541 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"2",
"of",
"4",
"Summary",
"of",
"July",
"31",
"Teleconference",
"with",
"FDA",
"(J.",
"Haskins)",
"-",
"Continued",
">",
"The",
"group",
"summarized",
"the",
"FDA's",
"concerns",
"as",
"follows:",
">",
"The",
"FDA",
"is",
"not",
"stating",
"that",
"ACTOS",
"specifically",
"causes",
"or",
"contributes",
"to",
"bladder",
"tumors.",
"The",
"FDA",
"no",
"longer",
"supports",
"Dr.",
"Cohen's",
"hypothesis,",
"since",
"the",
"tumor",
"promoter",
"study",
"data",
"they",
"received",
"demonstrated",
"the",
"presence",
"of",
"tumors",
"without",
"calculi.",
">",
"The",
"FDA",
"no",
"longer",
"feels",
"that",
"they",
"understand",
"how",
"these",
"findings",
"relate",
"to",
"humans.",
"Update",
"from",
"TCI",
"Meeting",
"with",
"CEO",
"(Mr.",
"Saito)",
"Mr.",
"Saito",
"updated",
"the",
"CEO",
"on",
"this",
"situation",
"on",
"August",
"6.",
"The",
"following",
"strategy",
"was",
"decided",
"on:",
">",
"Attempt",
"to",
"keep",
"current",
"carcinogenicity",
"label",
"wording;",
"if",
"not",
"possible,",
"request",
"that",
"same",
"labeling",
"be",
"applied",
"to",
"Avandia",
">",
"Find",
"rationale",
"to",
"support",
"not",
"establishing",
"monitoring",
"plan,",
"but",
"if",
"necessary,",
"would",
"compromise",
"on",
"monitoring",
"wording",
"to",
"avoid",
"changing",
"carcinogenicity",
"wording",
"Develop",
"argument",
"to",
"proceed",
"with",
"Actos",
"508",
"(safety/efficacy",
"in",
"pediatrics)",
"study",
"under",
"current",
"timelines,",
"but",
"are",
"willing",
"to",
"postpone",
">",
"The",
"following",
"timelines",
"were",
"established:",
"TPNA",
"to",
"send",
"outline",
"of",
"response",
"to",
"TCI",
"by",
"August",
"19",
"Mr.",
"Saito",
"will",
"present",
"outline",
"to",
"CEO",
"on",
"August",
"20",
"TPNA",
"will",
"send",
"draft",
"document",
"to",
"TCI,",
"TEUR&D,",
"and",
"Lilly",
"on",
"August",
"21",
"Document",
"will",
"be",
"finalized",
"by",
"August",
"26",
"Response",
"will",
"be",
"sent",
"to",
"FDA",
"on",
"August",
"28",
">",
"Mr",
"Saito",
"also",
"presented",
"the",
"following",
"communication",
"structure",
"and",
"schematic",
"Leadership:",
"Claire",
"Thom,",
"David",
"Eckland,",
"Mr.",
"Saito",
">",
"Primary",
"contacts:",
"Mary",
"Ramstack,",
"Janet",
"Haskins,",
"Philip",
"Collett,",
"Mr.",
"Miyazaki",
">The",
"only",
"exception",
"to",
"this",
"schematic",
"will",
"be",
"that",
"on",
"August",
"26,",
"TPNA",
"will",
"communicate",
"directly",
"with",
"Lilly",
"to",
"distribute",
"the",
"draft",
"document",
"CEO",
"Mr",
"Saito",
"-",
"TPNA",
"TCI",
"labs",
"Lilly",
"FU",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487174",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooops.ucsf.edu/docs/myjf0226"
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] | Who updated the CEO on August 6? | Mr. Saito |
541 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"2",
"of",
"4",
"Summary",
"of",
"July",
"31",
"Teleconference",
"with",
"FDA",
"(J.",
"Haskins)",
"-",
"Continued",
">",
"The",
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"summarized",
"the",
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"concerns",
"as",
"follows:",
">",
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"FDA",
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"not",
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"that",
"ACTOS",
"specifically",
"causes",
"or",
"contributes",
"to",
"bladder",
"tumors.",
"The",
"FDA",
"no",
"longer",
"supports",
"Dr.",
"Cohen's",
"hypothesis,",
"since",
"the",
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"promoter",
"study",
"data",
"they",
"received",
"demonstrated",
"the",
"presence",
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"tumors",
"without",
"calculi.",
">",
"The",
"FDA",
"no",
"longer",
"feels",
"that",
"they",
"understand",
"how",
"these",
"findings",
"relate",
"to",
"humans.",
"Update",
"from",
"TCI",
"Meeting",
"with",
"CEO",
"(Mr.",
"Saito)",
"Mr.",
"Saito",
"updated",
"the",
"CEO",
"on",
"this",
"situation",
"on",
"August",
"6.",
"The",
"following",
"strategy",
"was",
"decided",
"on:",
">",
"Attempt",
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"carcinogenicity",
"label",
"wording;",
"if",
"not",
"possible,",
"request",
"that",
"same",
"labeling",
"be",
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"to",
"Avandia",
">",
"Find",
"rationale",
"to",
"support",
"not",
"establishing",
"monitoring",
"plan,",
"but",
"if",
"necessary,",
"would",
"compromise",
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"avoid",
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"508",
"(safety/efficacy",
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"timelines,",
"but",
"are",
"willing",
"to",
"postpone",
">",
"The",
"following",
"timelines",
"were",
"established:",
"TPNA",
"to",
"send",
"outline",
"of",
"response",
"to",
"TCI",
"by",
"August",
"19",
"Mr.",
"Saito",
"will",
"present",
"outline",
"to",
"CEO",
"on",
"August",
"20",
"TPNA",
"will",
"send",
"draft",
"document",
"to",
"TCI,",
"TEUR&D,",
"and",
"Lilly",
"on",
"August",
"21",
"Document",
"will",
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"by",
"August",
"26",
"Response",
"will",
"be",
"sent",
"to",
"FDA",
"on",
"August",
"28",
">",
"Mr",
"Saito",
"also",
"presented",
"the",
"following",
"communication",
"structure",
"and",
"schematic",
"Leadership:",
"Claire",
"Thom,",
"David",
"Eckland,",
"Mr.",
"Saito",
">",
"Primary",
"contacts:",
"Mary",
"Ramstack,",
"Janet",
"Haskins,",
"Philip",
"Collett,",
"Mr.",
"Miyazaki",
">The",
"only",
"exception",
"to",
"this",
"schematic",
"will",
"be",
"that",
"on",
"August",
"26,",
"TPNA",
"will",
"communicate",
"directly",
"with",
"Lilly",
"to",
"distribute",
"the",
"draft",
"document",
"CEO",
"Mr",
"Saito",
"-",
"TPNA",
"TCI",
"labs",
"Lilly",
"FU",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487174",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooops.ucsf.edu/docs/myjf0226"
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] | By when should TPNA send outline of response to TCI ? | August 19 |
541 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"2",
"of",
"4",
"Summary",
"of",
"July",
"31",
"Teleconference",
"with",
"FDA",
"(J.",
"Haskins)",
"-",
"Continued",
">",
"The",
"group",
"summarized",
"the",
"FDA's",
"concerns",
"as",
"follows:",
">",
"The",
"FDA",
"is",
"not",
"stating",
"that",
"ACTOS",
"specifically",
"causes",
"or",
"contributes",
"to",
"bladder",
"tumors.",
"The",
"FDA",
"no",
"longer",
"supports",
"Dr.",
"Cohen's",
"hypothesis,",
"since",
"the",
"tumor",
"promoter",
"study",
"data",
"they",
"received",
"demonstrated",
"the",
"presence",
"of",
"tumors",
"without",
"calculi.",
">",
"The",
"FDA",
"no",
"longer",
"feels",
"that",
"they",
"understand",
"how",
"these",
"findings",
"relate",
"to",
"humans.",
"Update",
"from",
"TCI",
"Meeting",
"with",
"CEO",
"(Mr.",
"Saito)",
"Mr.",
"Saito",
"updated",
"the",
"CEO",
"on",
"this",
"situation",
"on",
"August",
"6.",
"The",
"following",
"strategy",
"was",
"decided",
"on:",
">",
"Attempt",
"to",
"keep",
"current",
"carcinogenicity",
"label",
"wording;",
"if",
"not",
"possible,",
"request",
"that",
"same",
"labeling",
"be",
"applied",
"to",
"Avandia",
">",
"Find",
"rationale",
"to",
"support",
"not",
"establishing",
"monitoring",
"plan,",
"but",
"if",
"necessary,",
"would",
"compromise",
"on",
"monitoring",
"wording",
"to",
"avoid",
"changing",
"carcinogenicity",
"wording",
"Develop",
"argument",
"to",
"proceed",
"with",
"Actos",
"508",
"(safety/efficacy",
"in",
"pediatrics)",
"study",
"under",
"current",
"timelines,",
"but",
"are",
"willing",
"to",
"postpone",
">",
"The",
"following",
"timelines",
"were",
"established:",
"TPNA",
"to",
"send",
"outline",
"of",
"response",
"to",
"TCI",
"by",
"August",
"19",
"Mr.",
"Saito",
"will",
"present",
"outline",
"to",
"CEO",
"on",
"August",
"20",
"TPNA",
"will",
"send",
"draft",
"document",
"to",
"TCI,",
"TEUR&D,",
"and",
"Lilly",
"on",
"August",
"21",
"Document",
"will",
"be",
"finalized",
"by",
"August",
"26",
"Response",
"will",
"be",
"sent",
"to",
"FDA",
"on",
"August",
"28",
">",
"Mr",
"Saito",
"also",
"presented",
"the",
"following",
"communication",
"structure",
"and",
"schematic",
"Leadership:",
"Claire",
"Thom,",
"David",
"Eckland,",
"Mr.",
"Saito",
">",
"Primary",
"contacts:",
"Mary",
"Ramstack,",
"Janet",
"Haskins,",
"Philip",
"Collett,",
"Mr.",
"Miyazaki",
">The",
"only",
"exception",
"to",
"this",
"schematic",
"will",
"be",
"that",
"on",
"August",
"26,",
"TPNA",
"will",
"communicate",
"directly",
"with",
"Lilly",
"to",
"distribute",
"the",
"draft",
"document",
"CEO",
"Mr",
"Saito",
"-",
"TPNA",
"TCI",
"labs",
"Lilly",
"FU",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487174",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooops.ucsf.edu/docs/myjf0226"
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] | When will Mr. Saito present outline to CEO? | August 20 |
541 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"2",
"of",
"4",
"Summary",
"of",
"July",
"31",
"Teleconference",
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"(J.",
"Haskins)",
"-",
"Continued",
">",
"The",
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"Dr.",
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"since",
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"data",
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"the",
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"without",
"calculi.",
">",
"The",
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"no",
"longer",
"feels",
"that",
"they",
"understand",
"how",
"these",
"findings",
"relate",
"to",
"humans.",
"Update",
"from",
"TCI",
"Meeting",
"with",
"CEO",
"(Mr.",
"Saito)",
"Mr.",
"Saito",
"updated",
"the",
"CEO",
"on",
"this",
"situation",
"on",
"August",
"6.",
"The",
"following",
"strategy",
"was",
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"on:",
">",
"Attempt",
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"carcinogenicity",
"label",
"wording;",
"if",
"not",
"possible,",
"request",
"that",
"same",
"labeling",
"be",
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"to",
"Avandia",
">",
"Find",
"rationale",
"to",
"support",
"not",
"establishing",
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"plan,",
"but",
"if",
"necessary,",
"would",
"compromise",
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"avoid",
"changing",
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"508",
"(safety/efficacy",
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"timelines,",
"but",
"are",
"willing",
"to",
"postpone",
">",
"The",
"following",
"timelines",
"were",
"established:",
"TPNA",
"to",
"send",
"outline",
"of",
"response",
"to",
"TCI",
"by",
"August",
"19",
"Mr.",
"Saito",
"will",
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"outline",
"to",
"CEO",
"on",
"August",
"20",
"TPNA",
"will",
"send",
"draft",
"document",
"to",
"TCI,",
"TEUR&D,",
"and",
"Lilly",
"on",
"August",
"21",
"Document",
"will",
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"by",
"August",
"26",
"Response",
"will",
"be",
"sent",
"to",
"FDA",
"on",
"August",
"28",
">",
"Mr",
"Saito",
"also",
"presented",
"the",
"following",
"communication",
"structure",
"and",
"schematic",
"Leadership:",
"Claire",
"Thom,",
"David",
"Eckland,",
"Mr.",
"Saito",
">",
"Primary",
"contacts:",
"Mary",
"Ramstack,",
"Janet",
"Haskins,",
"Philip",
"Collett,",
"Mr.",
"Miyazaki",
">The",
"only",
"exception",
"to",
"this",
"schematic",
"will",
"be",
"that",
"on",
"August",
"26,",
"TPNA",
"will",
"communicate",
"directly",
"with",
"Lilly",
"to",
"distribute",
"the",
"draft",
"document",
"CEO",
"Mr",
"Saito",
"-",
"TPNA",
"TCI",
"labs",
"Lilly",
"FU",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487174",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooops.ucsf.edu/docs/myjf0226"
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] | By when will the document be finalized? | August 26 |
545 | [
"PENGAD",
"BOO-631-698",
"EXHIBIT",
"102",
"FDA",
"Conference",
"Call",
"on",
"July",
"31,",
"2002",
"TPNA",
"Personnel:",
"Wendell",
"Cheatham,",
"M.D.",
"Vice",
"President,",
"of",
"Medial",
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"Scientific",
"Affairs",
"Michael",
"Elisseou,",
"Ph.D.,",
"Director,",
"Product",
"Development",
"and",
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"Janet",
"Haskins,",
"Manager,",
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"Affairs",
"Ingrid",
"Hoos,",
"Director,",
"Regulatory",
"Affairs",
"John",
"Page,",
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"Safety",
"Alfonso",
"Perez,",
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"Director",
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"Clinical",
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"Mary",
"Ramstack,",
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"Manager,",
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"Claire",
"Thom,",
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"President,",
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"Orloff,",
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"Jena",
"Weber,",
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"Jeri",
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"and",
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"-",
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"Order",
"TAK-RAMSTM-00235775",
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"on",
"09/18/12",
"Source:",
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942,
594,
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606
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[
228,
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295,
996
],
[
299,
979,
774,
997
]
] | What is the last point in the table? | Evaluate Impact on Tak-559 |
548 | [
"Task",
"Notes",
"Lead",
"Responsibility",
"Due",
"Date",
"8.",
"COMPETITIVE",
"INTELLIGENCE",
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"team",
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"Q&",
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"11",
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"TEUR&D,",
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"1,",
"2002",
"Page",
"7",
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"-",
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"to",
"Protective",
"Order",
"TAK-THOMCL-00032216",
"Produced",
"in",
"MDL",
"on",
"02/21/13",
"Source:",
"https://www.indups318coo0ogts.ucsf.edu/docs/qtjf0226"
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151,
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209,
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820,
582,
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820,
594,
875,
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878,
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942,
594,
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[
228,
980,
295,
996
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[
299,
979,
774,
997
]
] | What is the Draft's Due Date? | August 5 |
501 | [
"Dr.",
"Tan",
"January",
"14,",
"1999",
"Page",
"5",
"ELI",
"LILLY",
"AND",
"COMPANY",
"COMPENSATION",
"AND",
"BENEFITS",
"PROGRAM",
"(CONTINUED)",
"Additional",
"Company",
"Benefits",
"Medical",
"and",
"Dental",
"Insurance",
"Prescription",
"Drug",
"Benefits",
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"Accounts",
"Illness",
"Pay",
"Extended",
"Disability",
"(Eligibility",
"begins",
"after",
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"service)",
"Credit",
"Union",
"Moving",
"Plan",
"(see",
"enclosed",
"brochure)",
"Retirement",
"Plan",
"Employee",
"Health",
"Services",
"Employee",
"Activities",
"Educational",
"Assistance",
"Program",
"Savings",
"Plan",
"Holiday",
"and",
"Vacation",
"Plan",
"Please",
"refer",
"to",
"the",
"\"Employee",
"Compensation\"",
"booklet",
"for",
"the",
"details.",
"Optional",
"Employee-Paid",
"Benefits",
"Supplemental",
"Life",
"Insurance",
"Dependent",
"Life",
"Insurance",
"Flexible",
"CarePlus",
"(life/long-term",
"care",
"insurance)",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-TANM-PF-00000050",
"Source:",
"https://www.indup6330-00005",
"ts.ucsf.edu/docs/ttjf0226"
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] | Which benefit start after 1 year of service? | Extended Disability |
543 | [
"Ms.",
"Wakamatsu,",
"Assistant",
"manager,",
"Dept.",
"Strategic",
"Development,",
"et",
"al.",
"Attachment:",
"NDA",
"schedule",
"for",
"each",
"project",
"approved",
"on",
"the",
"5th",
"GDC",
"1.",
"Openings",
"Remarks",
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"remarks.",
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"in",
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"decade,",
"concentrating",
"all",
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"the",
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"under",
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"Pharmaceutical",
"Development",
"Division",
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"Pharmaceutical",
"Company,",
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"the",
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"products,",
"which",
"is",
"the",
"decisive",
"factor",
"for",
"TAKEDA",
"business.",
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"in",
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"since",
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"no",
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"launched.",
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"this",
"situation",
"is",
"critical,",
"the",
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"Development",
"Division",
"is",
"thought",
"to",
"be",
"conservative",
"and",
"lack",
"of",
"challenging",
"spirit.",
"He",
"stated",
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"his",
"mission",
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"this",
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"atmosphere",
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"to",
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"launch",
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"earlier",
"than",
"scheduled.",
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"Not",
"Hidden",
"3.",
"MPDRAP-I",
"(Diabetes)",
"1)",
"AD-4833",
"Update",
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"508)",
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"discussing",
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"agonists",
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"impact",
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"at",
"this",
"moment.",
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"to",
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"\"White",
"paper\"",
"to",
"address",
"the",
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"issue.",
"US",
"commitment",
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"vs.",
"45mg",
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"341,",
"342,",
"343",
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"513",
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] | What is Ms Wakamatsu's role in Dept. Strategic Development? | Assistant manager |
526 | [
"08/07/2002",
"18:47",
"06",
"6204",
"2244",
".",
"2002'",
"08/08",
"21:50",
"FAX",
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"2244",
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"/",
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"Date:",
"Monday,",
"12",
"and",
"Tuesday,",
"13",
"August",
"2002",
"Venue:",
"TPNA,",
"Chicago",
"ISSUES",
"1.",
"They",
"requested",
"us",
"to",
"propose",
"a",
"method",
"by",
"which",
"to",
"monitor",
"bladder",
"toxicity",
"in",
"patients",
"in",
"our",
"long",
"term",
"phase",
"4",
"clinical",
"trials",
"(long",
"term",
"was",
"defined",
"as",
"at",
"least",
"1",
"year)",
"2.",
"They",
"indicated",
"an",
"inclination",
"to",
"rescind",
"the",
"written",
"request",
"for",
"pediatric",
"exclusivity",
"based",
"on",
"their",
"concern",
"about",
"bladder",
"tumors.",
"3.",
"They",
"requested",
"us",
"to",
"give",
"some",
"consideration",
"to",
"a",
"label",
"change",
"that",
"would",
"reflect",
"possible",
"relatedness",
"of",
"tumor",
"formation",
"to",
"mechanism",
"(dual",
"PPAR",
"agonist)",
"instead",
"of",
"the",
"current",
"language",
"(\"The",
"relationship",
"of",
"these",
"findings",
"in",
"male",
"rats",
"to",
"humans",
"is",
"unclear.\")",
"DISCUSSION",
"POINTS",
"to",
"briefly",
"review",
"the",
"toxicity",
"study",
"results",
"of",
"pioglitazone,",
"particularly",
"carcinogenicity",
"studies",
"b.",
"to",
"summarise",
"discussions",
"with",
"the",
"CPMP",
"to",
"submit",
"literature",
"suggesting",
"that",
"pioglitazone",
"suppresses",
"the",
"cell",
"growth,",
"particularly",
"urinary",
"bladder",
"cell",
"1.",
"to",
"perform",
"an",
"in-vitro",
"study",
"to",
"evaluate",
"the",
"cell",
"growth",
"and",
"cell",
"growth",
"inhibition",
"with",
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"e.",
"to",
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"carbonic",
"anhydrase",
"inhibiting",
"activity",
"of",
"NN622,",
"pioglitazone",
"and",
"rosiglitazone",
"f.",
"to",
"compare",
"PPAR",
"agonists",
"in",
"terms",
"of",
"alpha",
"and",
"gamma",
"activities",
"g.",
"to",
"differentiate",
"between",
"glitazones",
"and",
"glitazars",
"h.",
"to",
"consult",
"with",
"non-clinical",
"external",
"experts",
"for",
"their",
"expertise",
"i.",
"to",
"find",
"a",
"rationale",
"for",
"not",
"doing",
"clinical",
"monitoring",
"j-",
"a",
"monotoring",
"method",
"k",
".",
"a",
"case",
"control",
"study",
"1.",
"a",
"pharmacoepidemiology",
"study",
"m.",
"to",
"submit",
"a",
"report",
"from",
"a",
"Japanese",
"follow",
"up",
"study",
"for",
"pioglitazone",
"n.",
"to",
"assess",
"cases",
"from",
"database",
"search",
"for",
"pioglitazone",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-THOMCL-00019749",
"Produced",
"in",
"MDL",
"on",
"09/14/12",
"Source:",
"https://www.indupbodocoboosts.ucsf.edu/docs/pljf0226"
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] | Which drug's toxicity study results will be discussed ? | pioglitazone |
535 | [
"Task",
"Notes",
"Lead",
"Responsibility",
"Due",
"Date",
"4.",
"PEDIATRIC",
"STUDIES",
"(CONTINUED)",
"Evaluate",
"data",
"from",
"Actos",
"507",
">",
"Evaluate",
"data",
"to",
"support",
"Amy",
"Hagaman",
"August",
"5",
"ustification",
"to",
"proceed",
"with",
"Actos",
"508",
"Develop",
"additional",
"monitoring",
"Amy",
"Hagaman",
"plan",
"for",
"Actos",
"508",
"Evaluate",
"feasibility/business",
"T.",
"Muldoon",
"case",
"of",
"request",
"to",
"FDA",
"to",
"delay",
"start",
"of",
"Actos",
"50",
"M",
"Ramstack",
"pending",
"Actos",
"506",
"data;",
"J",
"Haskins",
"assess",
"impact",
"on",
"pediatric",
"exclusivity/patent",
"Draft",
"justification",
"for",
"Actos",
"508",
",",
">",
"Justification",
"should",
"be",
"Amy",
"Hagaman/Alfonso",
"August",
"12",
"based",
"on",
"rebuttal",
"of",
"FDA",
"Pere",
"hypothesis",
"regarding",
"mechanism",
"of",
"action",
"for",
"bladder",
"cancer",
"and",
"addition",
"of",
"clinical",
"monitoring",
"plan",
"to",
"protocol",
"Last",
"Update:",
"August",
"1,",
"2002",
"Page",
"3",
"of",
"7",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-THOMEL-00032212",
"Produced",
"in",
"MDL",
"on",
"02/21/13-",
"Source:",
"https://www.indupssiscoboots.ucsf.edu/docs/qtjf0226"
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298,
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] | How many pages are there in total as part of this document? | 7 |
540 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"4",
"of",
"4",
"Highlights",
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">",
"Philip",
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"urine",
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"quite",
"low;",
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"was",
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"high,",
"as",
"calculi",
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"In",
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"the",
"tumors",
"seen",
"in",
"rats",
"were",
"due",
"to",
"the",
"presence",
"of",
"calculi.",
"The",
"male",
"rat",
"urine",
"milieu",
"contributes",
"to",
"the",
"formation",
"of",
"calculi.",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
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"as",
"bipeds",
"do.",
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"Europe",
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"plan",
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"control",
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"post-approval",
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"issues",
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"the",
"initial",
"FDA",
"response.",
"However,",
"it",
"was",
"decided",
"that",
"this",
"argument",
"should",
"be",
"developed,",
"as",
"it",
"may",
"be",
"necessary",
"to",
"use",
"it",
"in",
"the",
"future,",
"and",
"action",
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"were",
"assigned",
"accordingly.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487176",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indug2/pg-00604s.ucsf.edu/docs/myjf0226"
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] | Who challenged authorities regrading implementing monitoring plan? | Takeda Europe |
540 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"4",
"of",
"4",
"Highlights",
"from",
"Cohen",
"Hypothesis",
"Discussion",
">",
"Philip",
"Collett",
"presented",
"an",
"outline",
"of",
"the",
"Cohen",
"hypothesis",
"Male",
"rat",
"urine",
"has",
"a",
"very",
"high",
"protein",
"content,",
"which",
"is",
"a",
"function",
"of",
"sex",
"hormones",
"Raising",
"the",
"pH",
"of",
"male",
"rat",
"urine",
"above",
"6.5",
"is",
"significant",
"in",
"the",
"development",
"of",
"calculi",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"humans",
"do",
"The",
"correlation",
"observed",
"in",
"Cohen's",
"paper",
"is",
"0.61.",
"The",
"European",
"authorities",
"initially",
"determined",
"this",
"to",
"be",
"quite",
"low;",
"however,",
"Dr.",
"Cohen",
"authored",
"an",
"expert",
"report",
"which",
"stated",
"that",
"the",
"0.61",
"correlation",
"was",
"actually",
"high,",
"as",
"calculi",
"can",
"dissolve",
"over",
"time.",
"In",
"summary,",
"the",
"tumors",
"seen",
"in",
"rats",
"were",
"due",
"to",
"the",
"presence",
"of",
"calculi.",
"The",
"male",
"rat",
"urine",
"milieu",
"contributes",
"to",
"the",
"formation",
"of",
"calculi.",
"Because",
"rats",
"are",
"quadropeds,",
"they",
"do",
"not",
"eliminate",
"calculi",
"as",
"bipeds",
"do.",
"Main",
"Points",
"from",
"Takeda",
"Europe",
"Experience",
"Takeda",
"Europe",
"successfully",
"employed",
"the",
"following",
"strategy:",
"Defended",
"Cohen",
"hypothesis,",
"despite",
"numerous",
"challenges",
"Stressed",
"the",
"\"one",
"sex,",
"one",
"species\"",
"argument",
"Challenged",
"authorities",
"regarding",
"implementing",
"monitoring",
"plan",
"Offered",
"to",
"conduct",
"a",
"case",
"control",
"study",
"post-approval",
"Highlights",
"from",
"PPAR",
"Agonist",
"Discussion",
"The",
"group",
"extensively",
"discussed",
"many",
"aspects",
"of",
"the",
"PPAR",
"mechanism",
"and",
"ultimately",
"decided",
"to",
"not",
"address",
"mechanistic",
"issues",
"in",
"the",
"initial",
"FDA",
"response.",
"However,",
"it",
"was",
"decided",
"that",
"this",
"argument",
"should",
"be",
"developed,",
"as",
"it",
"may",
"be",
"necessary",
"to",
"use",
"it",
"in",
"the",
"future,",
"and",
"action",
"items",
"were",
"assigned",
"accordingly.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487176",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indug2/pg-00604s.ucsf.edu/docs/myjf0226"
] | [
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893,
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[
915,
966,
979,
979
],
[
222,
982,
291,
997
],
[
294,
980,
775,
997
]
] | What content is high in male rat urine? | protein |
550 | [
"ACTOS",
"FDA",
"RESPONSE",
"MEETING",
"TPNA/TEUR&D/TCI",
"AUGUST",
"12-13,",
"2002",
"Attendees:",
"TPNA",
"TEUR&D",
"Sam",
"Hamanaka",
"David",
"Eckland",
"Claire",
"Thom",
"Yasuhiko",
"Wada",
"Ingrid",
"Hood",
"Glyn",
"Belcher",
"Alfonso",
"Perez",
"Philip",
"Collett",
"David",
"Recker",
"John",
"Page",
"TCI",
"Mary",
"Ramstack",
"Katsuhisa",
"Saito",
"Janet",
"Haskins",
"Masahiro",
"Miyazaki",
"Dan",
"Orlando",
"Takashi",
"Kuroiwa",
"David",
"Baron",
"Takashi",
"Nonoyama",
"Chris",
"Durack",
"Keiichiro",
"Sato",
"Larry",
"Hancock",
"Hiroyuki",
"Odaka",
"Bob",
"Ahlbrandt",
"Tom",
"Muldoon",
"Karen",
"Kaluzny",
"Summary",
"of",
"July",
"31",
"Teleconference",
"with",
"FDA",
"(J.",
"Haskins)",
">",
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"FDA",
"informed",
"TPNA",
"that",
"they",
"had",
"received",
"data",
"from",
"a",
"rat",
"tumor",
"promoter",
"study",
"using",
"dual",
"PPAR",
"agonists.",
"Pioglitazone",
"was",
"used",
"in",
"this",
"experiment,",
"and",
"the",
"group",
"of",
"rats",
"treated",
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"experienced",
"the",
"same",
"frequency",
"of",
"transitional",
"cell",
"tumors",
"as",
"the",
"group",
"treated",
"with",
"the",
"dual",
"PPAR",
"agonist",
"under",
"investigation.",
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"FDA",
"clarified",
"that",
"due",
"to",
"this",
"data,",
"they",
"had",
"concerns",
"with",
"the",
"dual",
"PPAR",
"mechanism,",
"and",
"considered",
"pioglitazone",
"to",
"have",
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"mechanism.",
">",
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"were",
"three",
"key",
"messages",
"from",
"the",
"teleconference:",
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"FDA",
"asked",
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"consider",
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"label",
"change,",
"as",
"they",
"feel",
"that",
"the",
"current",
"package",
"insert",
"does",
"not",
"adequately",
"inform",
"patients",
"of",
"the",
"risk",
"associated",
"with",
"bladder",
"tumors.",
"The",
"FDA",
"asked",
"TPNA",
"to",
"research",
"and",
"propose",
"a",
"monitoring",
"plan,",
"which",
"would",
"be",
"incorporated",
"into",
"clinical",
"trials.",
"The",
"FDA",
"stated",
"that",
"they",
"were",
"considering",
"rescinding",
"their",
"written",
"request",
"to",
"TPNA",
"to",
"conduct",
"pediatric",
"studies",
"with",
"pioglitazone.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487173",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indup2/Thgoood",
"ts.ucsf.edu/docs/myjf0226"
] | [
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700,
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608,
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704,
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280,
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387,
814
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390,
798,
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814
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429,
798,
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814
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491,
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814
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237,
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832
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276,
816,
330,
832
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335,
816,
368,
832
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372,
816,
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832
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817,
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832
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462,
817,
559,
832
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563,
816,
650,
832
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654,
816,
694,
832
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698,
815,
761,
832
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199,
834,
264,
849
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267,
834,
286,
849
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292,
834,
338,
849
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341,
834,
361,
849
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[
365,
834,
431,
849
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[
435,
834,
510,
850
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513,
834,
574,
850
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577,
834,
615,
850
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618,
835,
721,
850
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32,
950,
112,
964
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115,
951,
124,
964
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[
128,
951,
178,
964
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[
181,
951,
195,
964
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198,
951,
267,
964
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[
270,
951,
311,
964
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[
763,
949,
935,
964
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[
765,
967,
834,
980
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[
837,
967,
852,
979
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[
855,
967,
890,
979
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[
893,
967,
912,
979
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[
916,
966,
979,
979
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[
222,
982,
291,
997
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[
294,
982,
545,
998
],
[
549,
980,
775,
998
]
] | What kind of meeting is mentioned in this letter? | ACTOS FDA RESPONSE MEETING |
550 | [
"ACTOS",
"FDA",
"RESPONSE",
"MEETING",
"TPNA/TEUR&D/TCI",
"AUGUST",
"12-13,",
"2002",
"Attendees:",
"TPNA",
"TEUR&D",
"Sam",
"Hamanaka",
"David",
"Eckland",
"Claire",
"Thom",
"Yasuhiko",
"Wada",
"Ingrid",
"Hood",
"Glyn",
"Belcher",
"Alfonso",
"Perez",
"Philip",
"Collett",
"David",
"Recker",
"John",
"Page",
"TCI",
"Mary",
"Ramstack",
"Katsuhisa",
"Saito",
"Janet",
"Haskins",
"Masahiro",
"Miyazaki",
"Dan",
"Orlando",
"Takashi",
"Kuroiwa",
"David",
"Baron",
"Takashi",
"Nonoyama",
"Chris",
"Durack",
"Keiichiro",
"Sato",
"Larry",
"Hancock",
"Hiroyuki",
"Odaka",
"Bob",
"Ahlbrandt",
"Tom",
"Muldoon",
"Karen",
"Kaluzny",
"Summary",
"of",
"July",
"31",
"Teleconference",
"with",
"FDA",
"(J.",
"Haskins)",
">",
"The",
"FDA",
"informed",
"TPNA",
"that",
"they",
"had",
"received",
"data",
"from",
"a",
"rat",
"tumor",
"promoter",
"study",
"using",
"dual",
"PPAR",
"agonists.",
"Pioglitazone",
"was",
"used",
"in",
"this",
"experiment,",
"and",
"the",
"group",
"of",
"rats",
"treated",
"with",
"pioglitazone",
"experienced",
"the",
"same",
"frequency",
"of",
"transitional",
"cell",
"tumors",
"as",
"the",
"group",
"treated",
"with",
"the",
"dual",
"PPAR",
"agonist",
"under",
"investigation.",
"The",
"FDA",
"clarified",
"that",
"due",
"to",
"this",
"data,",
"they",
"had",
"concerns",
"with",
"the",
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"-",
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"TAK-RAMSTM-00487173",
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] | what kind of drug is used to treat the group of rats? | Pioglitazone |
552 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"3",
"of",
"4",
"Highlights/",
"Discussion",
"Points",
"from",
"Preclinical",
"Data",
"Presentation",
"In",
"the",
"rat",
"oncogenicity",
"study,",
"thickening",
"of",
"the",
"bladder",
"and",
"hypertrophy",
"of",
"the",
"urothelium",
"was",
"observed",
"in",
"male",
"rats.",
"These",
"findings",
"were",
"not",
"dose-",
"dependent.",
"Nearly",
"all",
"of",
"the",
"tumors",
"were",
"found",
"at",
"the",
"end",
"of",
"the",
"study",
"Some",
"cases",
"of",
"hyperplasia",
"were",
"seen",
"in",
"female",
"rats",
"at",
"the",
"highest",
"dose",
"level",
"only,",
"but",
"no",
"malignancies",
"were",
"seen.",
"There",
"were",
"no",
"tumors",
"seen",
"in",
"the",
"shorter",
"term",
"(12",
"month)",
"rat",
"toxicity",
"studies.",
"Glyn",
"Belcher",
"suggested",
"creating",
"a",
"summary",
"able",
"for",
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"toxicology",
"studies",
"with",
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"between",
"6",
"months",
"and",
"less",
"than",
"2",
"years.",
"In",
"the",
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"study,",
"hyperplasia",
"was",
"seen",
"in",
"male",
"mice",
"only.",
"These",
"findings",
"were",
"not",
"dose-dependent,",
"and",
"results",
"were",
"not",
"statistically",
"significant.",
"One",
"case",
"of",
"hyperplasia",
"was",
"observed",
"in",
"the",
"placebo",
"group.",
"Philip",
"Collett",
"stated",
"that",
"the",
"European",
"authorities",
"did",
"not",
"question",
"the",
"mouse",
"data",
"for",
"ACTOS,",
"but",
"rather",
"only",
"the",
"rat",
"data.",
"A",
"list",
"of",
"all",
"mutagenicity",
"studies",
"conducted",
"with",
"pioglitazone",
"was",
"shown,",
"and",
"David",
"Baron",
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"that",
"TCI",
"had",
"conducted",
"a",
"very",
"robust",
"program",
"that",
"went",
"beyond",
"regulatory",
"requirements.",
"A",
"study",
"observing",
"the",
"effects",
"of",
"pioglitazone",
"on",
"urinary",
"parameters",
"in",
"rats",
"was",
"conducted,",
"and",
"highlights",
"are",
"as",
"follows:",
"Simple",
"hyperplasia",
"seen",
"in",
"one",
"male",
">",
"Increase",
"in",
"urine",
"pH,",
"urine",
"volume,",
"microcrystal",
"count",
"Slight",
"decrease",
"in",
"magnesium,",
"calcium,",
"phosphorous,",
"sodium,",
"potassium,",
"and",
"chloride",
"Conclusion:",
"Changes",
"in",
"urinary",
"components",
"are",
"considered",
"to",
"be",
"factors",
"in",
"the",
"etiology",
"of",
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"lesions",
"of",
"the",
"bladder:",
"Pioglitazone",
"ingestion",
"Altered",
"urinary",
"physiology",
"Calculus",
"formation",
"Urothelial",
"ulceration",
"an",
"regeneration",
"(hyperplasia)",
"Benin",
"papilloma",
"Carcinoma",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487175",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooogs.ucsf.edu/docs/myjf0226"
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]
] | What is the due date to conduct review meeting for FDA package? | August 22 |
552 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"3",
"of",
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"Highlights/",
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"the",
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"thickening",
"of",
"the",
"bladder",
"and",
"hypertrophy",
"of",
"the",
"urothelium",
"was",
"observed",
"in",
"male",
"rats.",
"These",
"findings",
"were",
"not",
"dose-",
"dependent.",
"Nearly",
"all",
"of",
"the",
"tumors",
"were",
"found",
"at",
"the",
"end",
"of",
"the",
"study",
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"cases",
"of",
"hyperplasia",
"were",
"seen",
"in",
"female",
"rats",
"at",
"the",
"highest",
"dose",
"level",
"only,",
"but",
"no",
"malignancies",
"were",
"seen.",
"There",
"were",
"no",
"tumors",
"seen",
"in",
"the",
"shorter",
"term",
"(12",
"month)",
"rat",
"toxicity",
"studies.",
"Glyn",
"Belcher",
"suggested",
"creating",
"a",
"summary",
"able",
"for",
"all",
"toxicology",
"studies",
"with",
"durations",
"between",
"6",
"months",
"and",
"less",
"than",
"2",
"years.",
"In",
"the",
"mouse",
"oncogenicity",
"study,",
"hyperplasia",
"was",
"seen",
"in",
"male",
"mice",
"only.",
"These",
"findings",
"were",
"not",
"dose-dependent,",
"and",
"results",
"were",
"not",
"statistically",
"significant.",
"One",
"case",
"of",
"hyperplasia",
"was",
"observed",
"in",
"the",
"placebo",
"group.",
"Philip",
"Collett",
"stated",
"that",
"the",
"European",
"authorities",
"did",
"not",
"question",
"the",
"mouse",
"data",
"for",
"ACTOS,",
"but",
"rather",
"only",
"the",
"rat",
"data.",
"A",
"list",
"of",
"all",
"mutagenicity",
"studies",
"conducted",
"with",
"pioglitazone",
"was",
"shown,",
"and",
"David",
"Baron",
"acknowledged",
"that",
"TCI",
"had",
"conducted",
"a",
"very",
"robust",
"program",
"that",
"went",
"beyond",
"regulatory",
"requirements.",
"A",
"study",
"observing",
"the",
"effects",
"of",
"pioglitazone",
"on",
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"in",
"rats",
"was",
"conducted,",
"and",
"highlights",
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"as",
"follows:",
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"hyperplasia",
"seen",
"in",
"one",
"male",
">",
"Increase",
"in",
"urine",
"pH,",
"urine",
"volume,",
"microcrystal",
"count",
"Slight",
"decrease",
"in",
"magnesium,",
"calcium,",
"phosphorous,",
"sodium,",
"potassium,",
"and",
"chloride",
"Conclusion:",
"Changes",
"in",
"urinary",
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"are",
"considered",
"to",
"be",
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"in",
"the",
"etiology",
"of",
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"lesions",
"of",
"the",
"bladder:",
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"ingestion",
"Altered",
"urinary",
"physiology",
"Calculus",
"formation",
"Urothelial",
"ulceration",
"an",
"regeneration",
"(hyperplasia)",
"Benin",
"papilloma",
"Carcinoma",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487175",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooogs.ucsf.edu/docs/myjf0226"
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294,
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503,
980,
774,
998
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] | What is the time span where no tumors are seen? | shorter term (12 month) |
551 | [
"Task",
"Notes",
"Lead",
"Responsibility",
"Due",
"Date",
"6.",
"INTRODUCTORY/CONCLUSION",
"STATEMENTS",
"(CONTINUED)",
"Send",
"nonclinical",
"David",
"Baron",
"August",
"20",
"rationale/justification",
"section",
"to",
"medical",
"writing",
"for",
"compilation",
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"VERBIAGE",
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"1",
"-",
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"August",
"12",
"similar",
"class-related",
"issues",
"(T.e.,",
"ACE-inhibitors)",
"Last",
"Update:",
"August",
"1,",
"2002",
"Page",
"6",
"of",
"7",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-THOMCL-00032215",
"Produced",
"in",
"MDL",
"on",
"02/21/1",
"Source:",
"https://www.indup538coo097ts.ucsf.edu/docs/qtjf0226"
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] | Who is the lead responsible person for the compilation of FDA package? | Larry Hancock |
552 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"3",
"of",
"4",
"Highlights/",
"Discussion",
"Points",
"from",
"Preclinical",
"Data",
"Presentation",
"In",
"the",
"rat",
"oncogenicity",
"study,",
"thickening",
"of",
"the",
"bladder",
"and",
"hypertrophy",
"of",
"the",
"urothelium",
"was",
"observed",
"in",
"male",
"rats.",
"These",
"findings",
"were",
"not",
"dose-",
"dependent.",
"Nearly",
"all",
"of",
"the",
"tumors",
"were",
"found",
"at",
"the",
"end",
"of",
"the",
"study",
"Some",
"cases",
"of",
"hyperplasia",
"were",
"seen",
"in",
"female",
"rats",
"at",
"the",
"highest",
"dose",
"level",
"only,",
"but",
"no",
"malignancies",
"were",
"seen.",
"There",
"were",
"no",
"tumors",
"seen",
"in",
"the",
"shorter",
"term",
"(12",
"month)",
"rat",
"toxicity",
"studies.",
"Glyn",
"Belcher",
"suggested",
"creating",
"a",
"summary",
"able",
"for",
"all",
"toxicology",
"studies",
"with",
"durations",
"between",
"6",
"months",
"and",
"less",
"than",
"2",
"years.",
"In",
"the",
"mouse",
"oncogenicity",
"study,",
"hyperplasia",
"was",
"seen",
"in",
"male",
"mice",
"only.",
"These",
"findings",
"were",
"not",
"dose-dependent,",
"and",
"results",
"were",
"not",
"statistically",
"significant.",
"One",
"case",
"of",
"hyperplasia",
"was",
"observed",
"in",
"the",
"placebo",
"group.",
"Philip",
"Collett",
"stated",
"that",
"the",
"European",
"authorities",
"did",
"not",
"question",
"the",
"mouse",
"data",
"for",
"ACTOS,",
"but",
"rather",
"only",
"the",
"rat",
"data.",
"A",
"list",
"of",
"all",
"mutagenicity",
"studies",
"conducted",
"with",
"pioglitazone",
"was",
"shown,",
"and",
"David",
"Baron",
"acknowledged",
"that",
"TCI",
"had",
"conducted",
"a",
"very",
"robust",
"program",
"that",
"went",
"beyond",
"regulatory",
"requirements.",
"A",
"study",
"observing",
"the",
"effects",
"of",
"pioglitazone",
"on",
"urinary",
"parameters",
"in",
"rats",
"was",
"conducted,",
"and",
"highlights",
"are",
"as",
"follows:",
"Simple",
"hyperplasia",
"seen",
"in",
"one",
"male",
">",
"Increase",
"in",
"urine",
"pH,",
"urine",
"volume,",
"microcrystal",
"count",
"Slight",
"decrease",
"in",
"magnesium,",
"calcium,",
"phosphorous,",
"sodium,",
"potassium,",
"and",
"chloride",
"Conclusion:",
"Changes",
"in",
"urinary",
"components",
"are",
"considered",
"to",
"be",
"factors",
"in",
"the",
"etiology",
"of",
"proliferative",
"lesions",
"of",
"the",
"bladder:",
"Pioglitazone",
"ingestion",
"Altered",
"urinary",
"physiology",
"Calculus",
"formation",
"Urothelial",
"ulceration",
"an",
"regeneration",
"(hyperplasia)",
"Benin",
"papilloma",
"Carcinoma",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487175",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooogs.ucsf.edu/docs/myjf0226"
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] | According to mouse oncogenicity study, what was seen male mice only? | hyperplasia |
550 | [
"ACTOS",
"FDA",
"RESPONSE",
"MEETING",
"TPNA/TEUR&D/TCI",
"AUGUST",
"12-13,",
"2002",
"Attendees:",
"TPNA",
"TEUR&D",
"Sam",
"Hamanaka",
"David",
"Eckland",
"Claire",
"Thom",
"Yasuhiko",
"Wada",
"Ingrid",
"Hood",
"Glyn",
"Belcher",
"Alfonso",
"Perez",
"Philip",
"Collett",
"David",
"Recker",
"John",
"Page",
"TCI",
"Mary",
"Ramstack",
"Katsuhisa",
"Saito",
"Janet",
"Haskins",
"Masahiro",
"Miyazaki",
"Dan",
"Orlando",
"Takashi",
"Kuroiwa",
"David",
"Baron",
"Takashi",
"Nonoyama",
"Chris",
"Durack",
"Keiichiro",
"Sato",
"Larry",
"Hancock",
"Hiroyuki",
"Odaka",
"Bob",
"Ahlbrandt",
"Tom",
"Muldoon",
"Karen",
"Kaluzny",
"Summary",
"of",
"July",
"31",
"Teleconference",
"with",
"FDA",
"(J.",
"Haskins)",
">",
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"FDA",
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"that",
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"data",
"from",
"a",
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"tumor",
"promoter",
"study",
"using",
"dual",
"PPAR",
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"Pioglitazone",
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"in",
"this",
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"and",
"the",
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"rats",
"treated",
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"experienced",
"the",
"same",
"frequency",
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"cell",
"tumors",
"as",
"the",
"group",
"treated",
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"under",
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"data,",
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"and",
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"dual",
"PPAR",
"mechanism.",
">",
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"the",
"teleconference:",
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"FDA",
"asked",
"TPNA",
"to",
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"label",
"change,",
"as",
"they",
"feel",
"that",
"the",
"current",
"package",
"insert",
"does",
"not",
"adequately",
"inform",
"patients",
"of",
"the",
"risk",
"associated",
"with",
"bladder",
"tumors.",
"The",
"FDA",
"asked",
"TPNA",
"to",
"research",
"and",
"propose",
"a",
"monitoring",
"plan,",
"which",
"would",
"be",
"incorporated",
"into",
"clinical",
"trials.",
"The",
"FDA",
"stated",
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"they",
"were",
"considering",
"rescinding",
"their",
"written",
"request",
"to",
"TPNA",
"to",
"conduct",
"pediatric",
"studies",
"with",
"pioglitazone.",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487173",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indup2/Thgoood",
"ts.ucsf.edu/docs/myjf0226"
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222,
982,
291,
997
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[
294,
982,
545,
998
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[
549,
980,
775,
998
]
] | what kind of cell tumours experienced the same frequency when group of rats treated with pioglitazone? | transitional |
552 | [
"ACTOS",
"FDA",
"Response",
"Meeting",
"August",
"12-13,",
"2002",
"Page",
"3",
"of",
"4",
"Highlights/",
"Discussion",
"Points",
"from",
"Preclinical",
"Data",
"Presentation",
"In",
"the",
"rat",
"oncogenicity",
"study,",
"thickening",
"of",
"the",
"bladder",
"and",
"hypertrophy",
"of",
"the",
"urothelium",
"was",
"observed",
"in",
"male",
"rats.",
"These",
"findings",
"were",
"not",
"dose-",
"dependent.",
"Nearly",
"all",
"of",
"the",
"tumors",
"were",
"found",
"at",
"the",
"end",
"of",
"the",
"study",
"Some",
"cases",
"of",
"hyperplasia",
"were",
"seen",
"in",
"female",
"rats",
"at",
"the",
"highest",
"dose",
"level",
"only,",
"but",
"no",
"malignancies",
"were",
"seen.",
"There",
"were",
"no",
"tumors",
"seen",
"in",
"the",
"shorter",
"term",
"(12",
"month)",
"rat",
"toxicity",
"studies.",
"Glyn",
"Belcher",
"suggested",
"creating",
"a",
"summary",
"able",
"for",
"all",
"toxicology",
"studies",
"with",
"durations",
"between",
"6",
"months",
"and",
"less",
"than",
"2",
"years.",
"In",
"the",
"mouse",
"oncogenicity",
"study,",
"hyperplasia",
"was",
"seen",
"in",
"male",
"mice",
"only.",
"These",
"findings",
"were",
"not",
"dose-dependent,",
"and",
"results",
"were",
"not",
"statistically",
"significant.",
"One",
"case",
"of",
"hyperplasia",
"was",
"observed",
"in",
"the",
"placebo",
"group.",
"Philip",
"Collett",
"stated",
"that",
"the",
"European",
"authorities",
"did",
"not",
"question",
"the",
"mouse",
"data",
"for",
"ACTOS,",
"but",
"rather",
"only",
"the",
"rat",
"data.",
"A",
"list",
"of",
"all",
"mutagenicity",
"studies",
"conducted",
"with",
"pioglitazone",
"was",
"shown,",
"and",
"David",
"Baron",
"acknowledged",
"that",
"TCI",
"had",
"conducted",
"a",
"very",
"robust",
"program",
"that",
"went",
"beyond",
"regulatory",
"requirements.",
"A",
"study",
"observing",
"the",
"effects",
"of",
"pioglitazone",
"on",
"urinary",
"parameters",
"in",
"rats",
"was",
"conducted,",
"and",
"highlights",
"are",
"as",
"follows:",
"Simple",
"hyperplasia",
"seen",
"in",
"one",
"male",
">",
"Increase",
"in",
"urine",
"pH,",
"urine",
"volume,",
"microcrystal",
"count",
"Slight",
"decrease",
"in",
"magnesium,",
"calcium,",
"phosphorous,",
"sodium,",
"potassium,",
"and",
"chloride",
"Conclusion:",
"Changes",
"in",
"urinary",
"components",
"are",
"considered",
"to",
"be",
"factors",
"in",
"the",
"etiology",
"of",
"proliferative",
"lesions",
"of",
"the",
"bladder:",
"Pioglitazone",
"ingestion",
"Altered",
"urinary",
"physiology",
"Calculus",
"formation",
"Urothelial",
"ulceration",
"an",
"regeneration",
"(hyperplasia)",
"Benin",
"papilloma",
"Carcinoma",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RAMSTM-00487175",
"Produced",
"in",
"MDL",
"on",
"03/06/13",
"Source:",
"https://www.indusp2/phg",
"oooogs.ucsf.edu/docs/myjf0226"
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] | who conducted robust program? | TCI |
551 | [
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"Due",
"Date",
"6.",
"INTRODUCTORY/CONCLUSION",
"STATEMENTS",
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210,
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822,
580,
955,
592
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824,
594,
877,
605
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880,
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891,
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923,
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943,
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980,
295,
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299,
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] | What is the due date for sending FDA Document to Regulatory Affairs? | August 26 |
551 | [
"Task",
"Notes",
"Lead",
"Responsibility",
"Due",
"Date",
"6.",
"INTRODUCTORY/CONCLUSION",
"STATEMENTS",
"(CONTINUED)",
"Send",
"nonclinical",
"David",
"Baron",
"August",
"20",
"rationale/justification",
"section",
"to",
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"writing",
"for",
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"package",
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"August",
"21",
"review",
"Conduct",
"review",
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"22",
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"26",
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"August",
"1",
"-",
"DONE",
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"12",
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"Update:",
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"1,",
"2002",
"Page",
"6",
"of",
"7",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-THOMCL-00032215",
"Produced",
"in",
"MDL",
"on",
"02/21/1",
"Source:",
"https://www.indup538coo097ts.ucsf.edu/docs/qtjf0226"
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] | What is the last updated date mentioned in this document? | August 1, 2002 |
554 | [
"Horizon",
"-",
"ACTOS",
"PRODUCTS",
"LIABILITY",
"CLAIMS",
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"1",
"of",
"2",
"Home",
"News",
"&",
"Events",
"People",
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"&",
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"&",
"Resources",
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"HOLD",
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"or",
"lawsuits",
"(\"claims\")",
"relating",
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"ACTOS@",
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"HCI).",
"As",
"a",
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"these",
"Litigation",
"claims,",
"all",
"documents,",
"materials,",
"Information",
"and",
"things",
"that",
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"or",
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"continue",
"to",
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"pertaining",
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"subject",
"to",
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"PRODUCTS",
"LIABILITY",
"CLAIMS",
"Additionally,",
"all",
"documents",
"and",
"materials",
"that",
"exist",
"or",
"continue",
"to",
"be",
"developed",
"pertaining",
"to",
"Combination",
"medicines",
"Involving",
"ACTOS@,",
"ACTIONS",
"whether",
"a",
"marketed",
"or",
"development",
"medicine,",
"also",
"continue",
"to",
"be",
"subject",
"Add",
"to",
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"Links",
"i",
"to",
"a",
"Legal",
"Hold.",
"Alert",
"Me",
"Each",
"Takeda",
"Employee",
"or",
"Contractor",
"shall",
"create",
"an",
"Outlook",
"Folder",
"entitled",
"\"ACTOS\"",
"beneath",
"the",
"\"Legal",
"Hold\"",
"folder",
"provided",
"as",
"part",
"of",
"the",
"implementation",
"of",
"CORP-B-019",
"\"E-mail",
"Management",
"and",
"Retention.\"",
"Contact",
"the",
"Help",
"Desk",
"if",
"your",
"Outlook",
"file",
"folder",
"structure",
"does",
"not",
"contain",
"a",
"\"Legal",
"Hold\"",
"folder.",
"This",
"means",
"that",
"all",
"documents,",
"materials,",
"and",
"computer",
"files",
"(Including",
"e-",
"malls,",
"word",
"processing",
"documents,",
"slides,",
"etc.)",
"falling",
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"this",
"category",
"must",
"continue",
"to",
"be",
"maintained",
"until",
"you",
"are",
"Informed",
"otherwise,",
"regardless",
"of",
"the",
"specified",
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"retention",
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"would",
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"under",
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"CORP-B-019",
"\"E-mail",
"Management",
"and",
"Retention\"",
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"And",
"Electronic",
"Storage",
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"HOLD.",
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"RECORDS:",
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"records",
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"in",
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"department.",
"For",
"documents,",
"materials,",
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"recorded",
"on",
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"media,",
"such",
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"medium,",
"that",
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"Schedules,",
"you",
"are",
"also",
"reminded",
"to",
"retain",
"such",
"material",
"in",
"your",
"department.",
"http://horizon/C3/ACTOS%20Product%20Liability%20Litiga/default.aspx",
"1/1",
"1/2007",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RIM30b6-00000678",
"Source:",
"https://www.indup5329cooooqts.ucsf.edu/docs/hrjf0226"
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] | Which product's liability claims are described here? | ACTOS PRODUCTS |
554 | [
"Horizon",
"-",
"ACTOS",
"PRODUCTS",
"LIABILITY",
"CLAIMS",
"Page",
"1",
"of",
"2",
"Home",
"News",
"&",
"Events",
"People",
"Workplace",
"&",
"Services",
"Culture",
"&",
"Values",
"Tools",
"&",
"Resources",
"Team",
"Horton",
"ACTOS",
"PRODUCTS",
"LIABILITY",
"D",
"EXHIBIT",
"HORIZON",
"CLAIMS",
"52",
"CURRENT",
"PENGAD",
"800-631-696",
"LOCATION",
"dome",
"LEGAL",
"HOLD",
"RELATED",
"TO",
"ACTOS",
"PRODUCTS",
"LIABILITY",
"CLAIMS:",
"PLEASE",
"READ",
"THIS",
"MESSAGE",
"CAREFULLY",
"Culture",
"&",
"Values",
"Office",
"of",
"Ethics",
"&",
"Compliance",
"Takeda",
"continues",
"to",
"be",
"involved",
"in",
"a",
"small",
"number",
"of",
"claims",
"or",
"lawsuits",
"(\"claims\")",
"relating",
"to",
"ACTOS@",
"(pioglitazone",
"HCI).",
"As",
"a",
"result",
"of",
"these",
"Litigation",
"claims,",
"all",
"documents,",
"materials,",
"Information",
"and",
"things",
"that",
"exist",
"or",
"Resources",
"continue",
"to",
"be",
"developed",
"pertaining",
"to",
"ACTOS@",
"have",
"been",
"and",
"continue",
"ACTOS",
"to",
"be",
"subject",
"to",
"a",
"Legal",
"Hold.",
"PRODUCTS",
"LIABILITY",
"CLAIMS",
"Additionally,",
"all",
"documents",
"and",
"materials",
"that",
"exist",
"or",
"continue",
"to",
"be",
"developed",
"pertaining",
"to",
"Combination",
"medicines",
"Involving",
"ACTOS@,",
"ACTIONS",
"whether",
"a",
"marketed",
"or",
"development",
"medicine,",
"also",
"continue",
"to",
"be",
"subject",
"Add",
"to",
"My",
"Links",
"i",
"to",
"a",
"Legal",
"Hold.",
"Alert",
"Me",
"Each",
"Takeda",
"Employee",
"or",
"Contractor",
"shall",
"create",
"an",
"Outlook",
"Folder",
"entitled",
"\"ACTOS\"",
"beneath",
"the",
"\"Legal",
"Hold\"",
"folder",
"provided",
"as",
"part",
"of",
"the",
"implementation",
"of",
"CORP-B-019",
"\"E-mail",
"Management",
"and",
"Retention.\"",
"Contact",
"the",
"Help",
"Desk",
"if",
"your",
"Outlook",
"file",
"folder",
"structure",
"does",
"not",
"contain",
"a",
"\"Legal",
"Hold\"",
"folder.",
"This",
"means",
"that",
"all",
"documents,",
"materials,",
"and",
"computer",
"files",
"(Including",
"e-",
"malls,",
"word",
"processing",
"documents,",
"slides,",
"etc.)",
"falling",
"into",
"this",
"category",
"must",
"continue",
"to",
"be",
"maintained",
"until",
"you",
"are",
"Informed",
"otherwise,",
"regardless",
"of",
"the",
"specified",
"record",
"retention",
"perlod",
"that",
"would",
"apply",
"to",
"such",
"materials",
"under",
"Takeda's",
"current",
"Records",
"Retention",
"Schedules",
"and",
"program",
"You",
"are",
"reminded",
"that",
"you",
"must",
"follow",
"the",
"requirements",
"of",
"both",
"BOP,",
"CORP-B-019",
"\"E-mail",
"Management",
"and",
"Retention\"",
"for",
"the",
"retention",
"of",
"electronic",
"materials,",
"and",
"\"Best",
"Practices",
"For",
"The",
"Physical",
"And",
"Electronic",
"Storage",
"Of",
"Materials",
"That",
"Must",
"Be",
"Retained",
"For",
"Legal",
"Reasons....\"",
"IN",
"ALL",
"CASES,",
"THE",
"FOLLOWING",
"INSTRUCTIONS",
"APPLY",
"TO",
"DOCUMENTS,",
"MATERIALS,",
"INFORMATION,",
"AND",
"THINGS,",
"IN",
"HARD",
"COPY",
"OR",
"ELECTRONIC",
"FORMAT,",
"THAT",
"ARE",
"REQUIRED",
"TO",
"BE",
"RETAINED",
"PURSUANT",
"TO",
"THIS",
"LEGAL",
"HOLD.",
"FOR",
"MATERIALS",
"THAT",
"ARE",
"RECORDS:",
"For",
"paper",
"materials,",
"documents,",
"information,",
"and",
"other",
"tangible",
"things,",
"that",
"are",
"records",
"as",
"defined",
"by",
"Takeda's",
"Records",
"Retention",
"Schedules,",
"you",
"are",
"required",
"to",
"retain",
"such",
"materials",
"in",
"your",
"department.",
"For",
"documents,",
"materials,",
"and",
"information",
"recorded",
"on",
"disposable",
"electronic",
"storage",
"media,",
"such",
"as",
"floppy",
"discs,",
"CDs,",
"video",
"or",
"any",
"other",
"portable",
"medium,",
"that",
"are",
"records",
"as",
"defined",
"by",
"Takeda's",
"Records",
"Retention",
"Schedules,",
"you",
"are",
"also",
"reminded",
"to",
"retain",
"such",
"material",
"in",
"your",
"department.",
"http://horizon/C3/ACTOS%20Product%20Liability%20Litiga/default.aspx",
"1/1",
"1/2007",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RIM30b6-00000678",
"Source:",
"https://www.indup5329cooooqts.ucsf.edu/docs/hrjf0226"
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] | What is the date mentioned in this document at the bottom? | 1/11/2007 |
553 | [
"PROactive'",
"Executive",
"Committee",
"Conference",
"Call",
"Minutes",
"of",
"Conference",
"Call",
"Date:",
"Monday",
"28\"",
"November",
"2005",
"EXHIBIT",
"NO.",
"Time:",
"1900",
"hours",
"In",
"attendance:",
"Professor",
"Erland",
"Erdmann",
"(EE)",
"rmandy",
"(JD)",
"Professor",
"Bernard",
"Charbonnel",
"(BC)",
"Professor",
"Massimo",
"Massi-Benedetti",
"(MMB)",
"Mr",
"lan",
"Moules",
"(IM)",
"Dr",
"Alfonso",
"Perez",
"(AP)",
"Mrs",
"Lucy",
"Bennett",
"(LB)",
"Dr",
"Susan",
"Crawford",
"(SC)",
"Apologies:",
"Professor",
"Ele",
"Ferrannini",
"Dr",
"Allan",
"Skene",
"Dr",
"Meng",
"Tan",
"Professor",
"Robert",
"Wilcox",
"1.",
"Minutes",
"of",
"last",
"meeting/conference",
"call",
"(15",
"October",
"2005)",
"Minutes",
"of",
"the",
"last",
"meeting/conference",
"call",
"held",
"on",
"15\"",
"October",
"2005",
"were",
"accepted.",
"The",
"EC",
"stressed",
"that",
"it",
"has",
"been",
"recorded",
"in",
"minutes",
"of",
"previous",
"meetings",
"and",
"teleconferences",
"that",
"its",
"members",
"wish",
"to",
"review",
"the",
"manuscript",
"for",
"all",
"abstracts",
"for",
"future",
"conferences",
"The",
"EC",
"discussed",
"the",
"stage",
"at",
"which",
"each",
"manuscript",
"would",
"be",
"ready",
"for",
"EC",
"review.",
"It",
"was",
"confirmed",
"that",
"the",
"EC",
"require",
"a",
"draft",
"of",
"the",
"manuscript",
"that",
"demonstrates",
"the",
"aims",
"of",
"the",
"paper,",
"how",
"to",
"interpret",
"the",
"data",
"and",
"how",
"the",
"manuscript",
"will",
"be",
"discussed",
"in",
"the",
"context",
"of",
"other",
"data.",
"This",
"is",
"more",
"than",
"simply",
"an",
"outline",
"of",
"what",
"would",
"be",
"included",
"in",
"the",
"manuscript",
"together",
"with",
"supporting",
"data.",
"Figures",
"and",
"tables",
"are",
"required",
"at",
"this",
"stage",
"of",
"review.",
"The",
"EC",
"Lead",
"will",
"take",
"responsibility",
"for",
"determining",
"the",
"stage",
"at",
"which",
"the",
"manuscript",
"is",
"ready",
"for",
"review.",
"The",
"EC",
"is",
"not",
"interested",
"in",
"refining",
"the",
"wording",
"of",
"manuscripts,",
"but",
"all",
"authors",
"would",
"need",
"to",
"agree",
"on",
"the",
"solidity",
"of",
"the",
"data",
"and",
"would",
"need",
"to",
"agree",
"to",
"presentation",
"of",
"an",
"abstract,",
"in",
"order",
"for",
"the",
"EC",
"to",
"carry",
"out",
"a",
"review.",
"JD",
"advised",
"the",
"EC",
"that",
"previous",
"indications",
"to",
"the",
"Committee",
"that",
"the",
"EAC",
"reviewed",
"all",
"cases",
"of",
"heart",
"failure",
"resulting",
"in",
"death,",
"as",
"discussed",
"during",
"the",
"last",
"meeting/call,",
"is",
"incorrect",
"The",
"Endpoint",
"Adjudication",
"Committee",
"reviewed",
"all",
"fatal",
"events,",
"however,",
"there",
"was",
"no",
"classification",
"regarding",
"death",
"due",
"to",
"heart",
"ailure",
"by",
"the",
"Committee/Panellists.",
"This",
"determination",
"was",
"made",
"by",
"the",
"Investigator.",
"Professor",
"Ryden",
"Karolinska",
"Institute,",
"Stockholm)",
"will",
"lead",
"an",
"independent",
"commission",
"into",
"heart",
"failure",
"and",
"the",
"results",
"of",
"these",
"findings",
"are",
"awaite",
"1.1",
"Revised",
"membership",
"of",
"the",
"Executive",
"Committee",
"Following",
"EE's",
"initial",
"discussions",
"with",
"Professor",
"Ferrannini",
"and",
"Professor",
"Wilcox,",
"IM",
"reported",
"that",
"he",
"had",
"written",
"to",
"them,",
"outlining",
"details",
"of",
"the",
"contract",
"held",
"with",
"EC",
"members,",
"together",
"with",
"the",
"proposed",
"honorarium.",
"The",
"actual",
"contracts",
"are",
"currently",
"held",
"up",
"within",
"Takeda",
"but",
"will",
"be",
"sent",
"out",
"within",
"one",
"week",
"Action:",
"IM",
"to",
"forward",
"EC",
"contracts",
"to",
"EC",
"members.",
"Takeda",
"\"PROspective",
"PioglitAzone",
"Clinical",
"Trial",
"In",
"MacroVascular",
"Events",
"Lilly",
"Page",
"1",
"of",
"6",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-MOULEI-00026121",
"Source:",
"https://www.indup6056-oooents.ucsf.edu/docs/Itjf0226"
] | [
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] | Mention the first name listed in the "apologies"? | Professor Ele Ferrannini |
554 | [
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"-",
"ACTOS",
"PRODUCTS",
"LIABILITY",
"CLAIMS",
"Page",
"1",
"of",
"2",
"Home",
"News",
"&",
"Events",
"People",
"Workplace",
"&",
"Services",
"Culture",
"&",
"Values",
"Tools",
"&",
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"Team",
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"dome",
"LEGAL",
"HOLD",
"RELATED",
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"LIABILITY",
"CLAIMS:",
"PLEASE",
"READ",
"THIS",
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"CAREFULLY",
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"Office",
"of",
"Ethics",
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"Compliance",
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"of",
"claims",
"or",
"lawsuits",
"(\"claims\")",
"relating",
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"HCI).",
"As",
"a",
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"claims,",
"all",
"documents,",
"materials,",
"Information",
"and",
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"or",
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"all",
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"materials",
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"or",
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"pertaining",
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"ACTIONS",
"whether",
"a",
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"or",
"development",
"medicine,",
"also",
"continue",
"to",
"be",
"subject",
"Add",
"to",
"My",
"Links",
"i",
"to",
"a",
"Legal",
"Hold.",
"Alert",
"Me",
"Each",
"Takeda",
"Employee",
"or",
"Contractor",
"shall",
"create",
"an",
"Outlook",
"Folder",
"entitled",
"\"ACTOS\"",
"beneath",
"the",
"\"Legal",
"Hold\"",
"folder",
"provided",
"as",
"part",
"of",
"the",
"implementation",
"of",
"CORP-B-019",
"\"E-mail",
"Management",
"and",
"Retention.\"",
"Contact",
"the",
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"Desk",
"if",
"your",
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"file",
"folder",
"structure",
"does",
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"Hold\"",
"folder.",
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"all",
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"materials,",
"and",
"computer",
"files",
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"e-",
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"slides,",
"etc.)",
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"this",
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"must",
"continue",
"to",
"be",
"maintained",
"until",
"you",
"are",
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"otherwise,",
"regardless",
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"and",
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"RETAINED",
"PURSUANT",
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"FOR",
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"RECORDS:",
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"materials,",
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"information,",
"and",
"other",
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"things,",
"that",
"are",
"records",
"as",
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"to",
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"in",
"your",
"department.",
"For",
"documents,",
"materials,",
"and",
"information",
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"media,",
"such",
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"any",
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"medium,",
"that",
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"Schedules,",
"you",
"are",
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"reminded",
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"retain",
"such",
"material",
"in",
"your",
"department.",
"http://horizon/C3/ACTOS%20Product%20Liability%20Litiga/default.aspx",
"1/1",
"1/2007",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-RIM30b6-00000678",
"Source:",
"https://www.indup5329cooooqts.ucsf.edu/docs/hrjf0226"
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915,
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857,
928
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[
859,
914,
907,
928
],
[
62,
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171,
971
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[
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955,
184,
971
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188,
955,
256,
971
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[
260,
956,
280,
971
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[
284,
956,
378,
972
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[
381,
956,
435,
972
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[
758,
957,
963,
973
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[
228,
982,
294,
998
],
[
298,
980,
772,
998
]
] | What is the exhibit number? | 52 |
553 | [
"PROactive'",
"Executive",
"Committee",
"Conference",
"Call",
"Minutes",
"of",
"Conference",
"Call",
"Date:",
"Monday",
"28\"",
"November",
"2005",
"EXHIBIT",
"NO.",
"Time:",
"1900",
"hours",
"In",
"attendance:",
"Professor",
"Erland",
"Erdmann",
"(EE)",
"rmandy",
"(JD)",
"Professor",
"Bernard",
"Charbonnel",
"(BC)",
"Professor",
"Massimo",
"Massi-Benedetti",
"(MMB)",
"Mr",
"lan",
"Moules",
"(IM)",
"Dr",
"Alfonso",
"Perez",
"(AP)",
"Mrs",
"Lucy",
"Bennett",
"(LB)",
"Dr",
"Susan",
"Crawford",
"(SC)",
"Apologies:",
"Professor",
"Ele",
"Ferrannini",
"Dr",
"Allan",
"Skene",
"Dr",
"Meng",
"Tan",
"Professor",
"Robert",
"Wilcox",
"1.",
"Minutes",
"of",
"last",
"meeting/conference",
"call",
"(15",
"October",
"2005)",
"Minutes",
"of",
"the",
"last",
"meeting/conference",
"call",
"held",
"on",
"15\"",
"October",
"2005",
"were",
"accepted.",
"The",
"EC",
"stressed",
"that",
"it",
"has",
"been",
"recorded",
"in",
"minutes",
"of",
"previous",
"meetings",
"and",
"teleconferences",
"that",
"its",
"members",
"wish",
"to",
"review",
"the",
"manuscript",
"for",
"all",
"abstracts",
"for",
"future",
"conferences",
"The",
"EC",
"discussed",
"the",
"stage",
"at",
"which",
"each",
"manuscript",
"would",
"be",
"ready",
"for",
"EC",
"review.",
"It",
"was",
"confirmed",
"that",
"the",
"EC",
"require",
"a",
"draft",
"of",
"the",
"manuscript",
"that",
"demonstrates",
"the",
"aims",
"of",
"the",
"paper,",
"how",
"to",
"interpret",
"the",
"data",
"and",
"how",
"the",
"manuscript",
"will",
"be",
"discussed",
"in",
"the",
"context",
"of",
"other",
"data.",
"This",
"is",
"more",
"than",
"simply",
"an",
"outline",
"of",
"what",
"would",
"be",
"included",
"in",
"the",
"manuscript",
"together",
"with",
"supporting",
"data.",
"Figures",
"and",
"tables",
"are",
"required",
"at",
"this",
"stage",
"of",
"review.",
"The",
"EC",
"Lead",
"will",
"take",
"responsibility",
"for",
"determining",
"the",
"stage",
"at",
"which",
"the",
"manuscript",
"is",
"ready",
"for",
"review.",
"The",
"EC",
"is",
"not",
"interested",
"in",
"refining",
"the",
"wording",
"of",
"manuscripts,",
"but",
"all",
"authors",
"would",
"need",
"to",
"agree",
"on",
"the",
"solidity",
"of",
"the",
"data",
"and",
"would",
"need",
"to",
"agree",
"to",
"presentation",
"of",
"an",
"abstract,",
"in",
"order",
"for",
"the",
"EC",
"to",
"carry",
"out",
"a",
"review.",
"JD",
"advised",
"the",
"EC",
"that",
"previous",
"indications",
"to",
"the",
"Committee",
"that",
"the",
"EAC",
"reviewed",
"all",
"cases",
"of",
"heart",
"failure",
"resulting",
"in",
"death,",
"as",
"discussed",
"during",
"the",
"last",
"meeting/call,",
"is",
"incorrect",
"The",
"Endpoint",
"Adjudication",
"Committee",
"reviewed",
"all",
"fatal",
"events,",
"however,",
"there",
"was",
"no",
"classification",
"regarding",
"death",
"due",
"to",
"heart",
"ailure",
"by",
"the",
"Committee/Panellists.",
"This",
"determination",
"was",
"made",
"by",
"the",
"Investigator.",
"Professor",
"Ryden",
"Karolinska",
"Institute,",
"Stockholm)",
"will",
"lead",
"an",
"independent",
"commission",
"into",
"heart",
"failure",
"and",
"the",
"results",
"of",
"these",
"findings",
"are",
"awaite",
"1.1",
"Revised",
"membership",
"of",
"the",
"Executive",
"Committee",
"Following",
"EE's",
"initial",
"discussions",
"with",
"Professor",
"Ferrannini",
"and",
"Professor",
"Wilcox,",
"IM",
"reported",
"that",
"he",
"had",
"written",
"to",
"them,",
"outlining",
"details",
"of",
"the",
"contract",
"held",
"with",
"EC",
"members,",
"together",
"with",
"the",
"proposed",
"honorarium.",
"The",
"actual",
"contracts",
"are",
"currently",
"held",
"up",
"within",
"Takeda",
"but",
"will",
"be",
"sent",
"out",
"within",
"one",
"week",
"Action:",
"IM",
"to",
"forward",
"EC",
"contracts",
"to",
"EC",
"members.",
"Takeda",
"\"PROspective",
"PioglitAzone",
"Clinical",
"Trial",
"In",
"MacroVascular",
"Events",
"Lilly",
"Page",
"1",
"of",
"6",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-MOULEI-00026121",
"Source:",
"https://www.indup6056-oooents.ucsf.edu/docs/Itjf0226"
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] | when was the last meeting/conference call held on ? | 15th October 2005 |
542 | [
"107",
"FDA",
"Conference",
"Call:",
"August",
"13,",
"2002",
"PENGAD",
"800-631-698",
"EXHIBIT",
"FDA",
"Personnel:",
"Jeri",
"El-Hage,",
"Ph.D.,",
"Toxicology",
"Team",
"Leader",
"Jena",
"Weber,",
"Project",
"Manager",
"TPNA",
"Personnel:",
"David",
"Baron,",
"Ph.D.,",
"Director,",
"Nonclinical",
"Safety",
"and",
"Efficacy",
"Janet",
"Haskins,",
"Manager,",
"Regulatory",
"Affairs",
"Pat",
"Frank,",
"Ph.D.,",
"TPNA",
"Consultant",
"This",
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"was",
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"a",
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"to",
"a",
"discussion",
"between",
"TPNA",
"and",
"the",
"Agency",
"on",
"July",
"31,",
"2002.",
"The",
"purpose",
"of",
"this",
"call",
"was",
"so",
"that",
"Dr.",
"El-Hage",
"could",
"expand",
"upon",
"the",
"nonclinical",
"data",
"related",
"to",
"dual",
"PPAR",
"agonists",
"that",
"were",
"discussed",
"with",
"TPNA",
"on",
"July",
"31,",
"2002.",
"Dr.",
"El-Hage",
"informed",
"TPNA",
"that",
"in",
"standard",
"2-year",
"rat",
"and",
"mouse",
"bioassay",
"studies,",
"several",
"other",
"dual",
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"agonists",
"were",
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"transitional",
"cell",
"tumors",
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"and",
"kidneys",
"of",
"male",
"and",
"female",
"rats",
"and",
"male",
"mice.",
"Therefore,",
"the",
"Division",
"is",
"considering",
"the",
"relevance",
"of",
"these",
"findings",
"to",
"this",
"pharmaceutical",
"class",
"of",
"drugs.",
"She",
"also",
"noted",
"that",
"in",
"follow-up",
"unspecified",
"mechanistic",
"studies",
"of",
"the",
"other",
"dual",
"PPAR",
"agonists,",
"no",
"evidence",
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"irritation",
"by",
"crystalluria",
"or",
"calculi",
"was",
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"Dr.",
"El-Hage",
"then",
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"a",
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"that",
"was",
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"by",
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"which",
"pioglitazone",
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"was",
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"as",
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".",
"BBN",
"was",
"given",
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"male",
"Fisher",
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"in",
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"water",
"for",
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".",
"Pioglitazone",
"40",
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"The",
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"plus",
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"(No",
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"were",
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"El-Hage",
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"were",
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"and",
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")",
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".",
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"Duration",
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"was",
"32-weeks",
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"Results:",
".",
"85%",
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"the",
"other",
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"groups",
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"formation.",
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"formation",
"was",
"not",
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"group,",
"but",
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"unspecified",
"methodology",
"15%",
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"animals",
"in",
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"negative",
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"group",
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"presence",
"of",
"calculi",
"formation",
"(uracil).",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-NAUGHP-00080811",
"Source:",
"https://www.indup53720boots.ucsf.edu/docs/jsjf0226"
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] | What is the exhibit number? | 107 |
553 | [
"PROactive'",
"Executive",
"Committee",
"Conference",
"Call",
"Minutes",
"of",
"Conference",
"Call",
"Date:",
"Monday",
"28\"",
"November",
"2005",
"EXHIBIT",
"NO.",
"Time:",
"1900",
"hours",
"In",
"attendance:",
"Professor",
"Erland",
"Erdmann",
"(EE)",
"rmandy",
"(JD)",
"Professor",
"Bernard",
"Charbonnel",
"(BC)",
"Professor",
"Massimo",
"Massi-Benedetti",
"(MMB)",
"Mr",
"lan",
"Moules",
"(IM)",
"Dr",
"Alfonso",
"Perez",
"(AP)",
"Mrs",
"Lucy",
"Bennett",
"(LB)",
"Dr",
"Susan",
"Crawford",
"(SC)",
"Apologies:",
"Professor",
"Ele",
"Ferrannini",
"Dr",
"Allan",
"Skene",
"Dr",
"Meng",
"Tan",
"Professor",
"Robert",
"Wilcox",
"1.",
"Minutes",
"of",
"last",
"meeting/conference",
"call",
"(15",
"October",
"2005)",
"Minutes",
"of",
"the",
"last",
"meeting/conference",
"call",
"held",
"on",
"15\"",
"October",
"2005",
"were",
"accepted.",
"The",
"EC",
"stressed",
"that",
"it",
"has",
"been",
"recorded",
"in",
"minutes",
"of",
"previous",
"meetings",
"and",
"teleconferences",
"that",
"its",
"members",
"wish",
"to",
"review",
"the",
"manuscript",
"for",
"all",
"abstracts",
"for",
"future",
"conferences",
"The",
"EC",
"discussed",
"the",
"stage",
"at",
"which",
"each",
"manuscript",
"would",
"be",
"ready",
"for",
"EC",
"review.",
"It",
"was",
"confirmed",
"that",
"the",
"EC",
"require",
"a",
"draft",
"of",
"the",
"manuscript",
"that",
"demonstrates",
"the",
"aims",
"of",
"the",
"paper,",
"how",
"to",
"interpret",
"the",
"data",
"and",
"how",
"the",
"manuscript",
"will",
"be",
"discussed",
"in",
"the",
"context",
"of",
"other",
"data.",
"This",
"is",
"more",
"than",
"simply",
"an",
"outline",
"of",
"what",
"would",
"be",
"included",
"in",
"the",
"manuscript",
"together",
"with",
"supporting",
"data.",
"Figures",
"and",
"tables",
"are",
"required",
"at",
"this",
"stage",
"of",
"review.",
"The",
"EC",
"Lead",
"will",
"take",
"responsibility",
"for",
"determining",
"the",
"stage",
"at",
"which",
"the",
"manuscript",
"is",
"ready",
"for",
"review.",
"The",
"EC",
"is",
"not",
"interested",
"in",
"refining",
"the",
"wording",
"of",
"manuscripts,",
"but",
"all",
"authors",
"would",
"need",
"to",
"agree",
"on",
"the",
"solidity",
"of",
"the",
"data",
"and",
"would",
"need",
"to",
"agree",
"to",
"presentation",
"of",
"an",
"abstract,",
"in",
"order",
"for",
"the",
"EC",
"to",
"carry",
"out",
"a",
"review.",
"JD",
"advised",
"the",
"EC",
"that",
"previous",
"indications",
"to",
"the",
"Committee",
"that",
"the",
"EAC",
"reviewed",
"all",
"cases",
"of",
"heart",
"failure",
"resulting",
"in",
"death,",
"as",
"discussed",
"during",
"the",
"last",
"meeting/call,",
"is",
"incorrect",
"The",
"Endpoint",
"Adjudication",
"Committee",
"reviewed",
"all",
"fatal",
"events,",
"however,",
"there",
"was",
"no",
"classification",
"regarding",
"death",
"due",
"to",
"heart",
"ailure",
"by",
"the",
"Committee/Panellists.",
"This",
"determination",
"was",
"made",
"by",
"the",
"Investigator.",
"Professor",
"Ryden",
"Karolinska",
"Institute,",
"Stockholm)",
"will",
"lead",
"an",
"independent",
"commission",
"into",
"heart",
"failure",
"and",
"the",
"results",
"of",
"these",
"findings",
"are",
"awaite",
"1.1",
"Revised",
"membership",
"of",
"the",
"Executive",
"Committee",
"Following",
"EE's",
"initial",
"discussions",
"with",
"Professor",
"Ferrannini",
"and",
"Professor",
"Wilcox,",
"IM",
"reported",
"that",
"he",
"had",
"written",
"to",
"them,",
"outlining",
"details",
"of",
"the",
"contract",
"held",
"with",
"EC",
"members,",
"together",
"with",
"the",
"proposed",
"honorarium.",
"The",
"actual",
"contracts",
"are",
"currently",
"held",
"up",
"within",
"Takeda",
"but",
"will",
"be",
"sent",
"out",
"within",
"one",
"week",
"Action:",
"IM",
"to",
"forward",
"EC",
"contracts",
"to",
"EC",
"members.",
"Takeda",
"\"PROspective",
"PioglitAzone",
"Clinical",
"Trial",
"In",
"MacroVascular",
"Events",
"Lilly",
"Page",
"1",
"of",
"6",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAK-MOULEI-00026121",
"Source:",
"https://www.indup6056-oooents.ucsf.edu/docs/Itjf0226"
] | [
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] | what is the date mentioned under the title - " minutes of conference call"? | Monday 28th November 2005 |
558 | [
"Rationale",
"for",
"3",
"Segments",
"actos",
"pioglitazone",
"HCI",
"For",
"performance",
"that",
"benefits",
"the",
"body.",
"Summary",
"of",
"Segment",
"Attractiveness",
"(based",
"on",
"current",
"situation",
"&",
"future",
"trends)",
"Treatment",
"Machines,",
"Life",
"Negotiators,",
"Struggle",
"for",
"Control",
"60",
"50",
"Opportunity",
"40",
"All",
"3",
"Segments",
"Have",
"Consistent",
"Needs",
"20",
"10",
"7:",
"1101",
"7/24/01",
"Company",
"Confidential",
"File",
"name/location",
"Copyright",
"@",
"2000",
"Eli",
"Lilly",
"and",
"Company",
"Source:",
"https://www.indupt4608coooo2ts.ucsf.edu/docs/xqjf0226"
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] | What is the heading of this document? | Rationale for 3 segments |
556 | [
"(2)",
"The",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"properly",
"store,",
"and",
"dispose",
"of,",
"any",
"stored",
"documents",
"assigned,",
"and",
"properly",
"store",
"any",
"records",
"relevant",
"to",
"those",
"storage",
"and",
"disposal.",
"(3)",
"In",
"case",
"the",
"document",
"storage",
"functions",
"are",
"reorganized",
"or",
"abolished",
"due",
"to",
"organizational",
"changes,",
"etc.,",
"the",
"core",
"organizations",
"taking",
"over",
"the",
"document-related",
"operations",
"shall",
"continue",
"to",
"store",
"the",
"documents",
"and",
"retain",
"the",
"disposal",
"records.",
"Chapter",
"3",
"Document",
"Storage",
"Period",
"Article",
"7",
"(Document",
"Storage",
"Period)",
"The",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"establish",
"storage",
"periods",
"for",
"different",
"types",
"of",
"assigned",
"documents,",
"by",
"checking",
"opinions",
"of",
"the",
"relevant",
"internal",
"functions,",
"if",
"necessary,",
"and",
"distinguish",
"and",
"designate",
"the",
"periods,",
"in",
"principle,",
"as",
"indicated",
"below.",
"However,",
"if",
"the",
"storage",
"periods",
"are",
"specified",
"by",
"laws,",
"regulations",
"or",
"Company",
"Regulations,",
"they",
"shall",
"be",
"established",
"in",
"compliance",
"with",
"those",
"laws,",
"regulations",
"and",
"Company",
"Regulations.",
"The",
"starting",
"point",
"for",
"determining",
"a",
"storage",
"period",
"shall",
"be,",
"in",
"principle,",
"the",
"date",
"on",
"which",
"the",
"document",
"is",
"created.",
"1.",
"To",
"be",
"stored",
"permanently",
"2.",
"To",
"be",
"stored",
"for",
"ten",
"years",
"3.",
"To",
"be",
"stored",
"for",
"seven",
"years",
"4.",
"To",
"be",
"stored",
"for",
"five",
"years",
"5.",
"To",
"be",
"stored",
"for",
"three",
"years",
"6.",
"To",
"be",
"stored",
"for",
"one",
"year",
"7.",
"To",
"be",
"stored",
"for",
"less",
"than",
"one",
"year",
"(to",
"be",
"disposed",
"of",
"promptly",
"after",
"use)",
"(2)",
"If",
"a",
"document",
"turns",
"out",
"not",
"to",
"be",
"categorized",
"into",
"any",
"document",
"types",
"designated",
"for",
"specified",
"storage",
"periods,",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"establish",
"a",
"storage",
"period",
"for",
"the",
"new",
"document",
"type,",
"as",
"stipulated",
"in",
"the",
"preceding",
"paragraph.",
"(3)",
"Concerning",
"the",
"provisions",
"set",
"forth",
"in",
"Paragraph",
"I",
"above,",
"the",
"following",
"documents",
"shall",
"be",
"stored",
"permanently.",
"1.",
"Articles",
"of",
"Incorporation",
"and",
"Company",
"Regulations",
"2.",
"Important",
"documents",
"concerning",
"the",
"General",
"Meetings",
"of",
"Shareholders,",
"the",
"Board",
"of",
"Directors,",
"the",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"important",
"conferences.",
"3.",
"Important",
"documents",
"concerning",
"mid/long-range",
"management",
"policies",
"and",
"plans",
"4.",
"Important",
"documents",
"concerning",
"the",
"Company's",
"rights",
"and",
"duties,",
"including",
"important",
"contracts,",
"lawsuits,",
"registrations,",
"etc.",
"Important",
"documents",
"concerning",
"budgets,",
"account",
"settlements,",
"and",
"other",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAKJ-TPC-00000254",
"Source:",
"https://www.indup2378",
"0boats.ucsf.edu/docs/jpjf0226"
] | [
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] | What are the three segments indicated in the graph? | Treatment Machines, Life Negotiators, Struggle for Control |
556 | [
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"4.",
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"To",
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"To",
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"for",
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"designated",
"for",
"specified",
"storage",
"periods,",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"establish",
"a",
"storage",
"period",
"for",
"the",
"new",
"document",
"type,",
"as",
"stipulated",
"in",
"the",
"preceding",
"paragraph.",
"(3)",
"Concerning",
"the",
"provisions",
"set",
"forth",
"in",
"Paragraph",
"I",
"above,",
"the",
"following",
"documents",
"shall",
"be",
"stored",
"permanently.",
"1.",
"Articles",
"of",
"Incorporation",
"and",
"Company",
"Regulations",
"2.",
"Important",
"documents",
"concerning",
"the",
"General",
"Meetings",
"of",
"Shareholders,",
"the",
"Board",
"of",
"Directors,",
"the",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"important",
"conferences.",
"3.",
"Important",
"documents",
"concerning",
"mid/long-range",
"management",
"policies",
"and",
"plans",
"4.",
"Important",
"documents",
"concerning",
"the",
"Company's",
"rights",
"and",
"duties,",
"including",
"important",
"contracts,",
"lawsuits,",
"registrations,",
"etc.",
"Important",
"documents",
"concerning",
"budgets,",
"account",
"settlements,",
"and",
"other",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAKJ-TPC-00000254",
"Source:",
"https://www.indup2378",
"0boats.ucsf.edu/docs/jpjf0226"
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] | what is the "document storage period " article number? | 7 |
558 | [
"Rationale",
"for",
"3",
"Segments",
"actos",
"pioglitazone",
"HCI",
"For",
"performance",
"that",
"benefits",
"the",
"body.",
"Summary",
"of",
"Segment",
"Attractiveness",
"(based",
"on",
"current",
"situation",
"&",
"future",
"trends)",
"Treatment",
"Machines,",
"Life",
"Negotiators,",
"Struggle",
"for",
"Control",
"60",
"50",
"Opportunity",
"40",
"All",
"3",
"Segments",
"Have",
"Consistent",
"Needs",
"20",
"10",
"7:",
"1101",
"7/24/01",
"Company",
"Confidential",
"File",
"name/location",
"Copyright",
"@",
"2000",
"Eli",
"Lilly",
"and",
"Company",
"Source:",
"https://www.indupt4608coooo2ts.ucsf.edu/docs/xqjf0226"
] | [
[
93,
134,
279,
188
],
[
290,
134,
349,
190
],
[
355,
134,
381,
190
],
[
392,
134,
590,
195
],
[
784,
104,
941,
151
],
[
782,
147,
904,
179
],
[
908,
145,
945,
176
],
[
783,
184,
809,
206
],
[
811,
186,
909,
206
],
[
911,
184,
943,
206
],
[
783,
203,
842,
224
],
[
845,
206,
869,
225
],
[
871,
206,
909,
225
],
[
287,
251,
377,
275
],
[
383,
251,
404,
276
],
[
407,
251,
497,
276
],
[
500,
251,
634,
276
],
[
259,
281,
326,
305
],
[
330,
281,
354,
305
],
[
359,
281,
430,
305
],
[
433,
281,
511,
305
],
[
521,
280,
534,
305
],
[
540,
279,
595,
306
],
[
599,
279,
667,
306
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[
85,
338,
205,
365
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[
208,
338,
336,
366
],
[
340,
338,
383,
366
],
[
390,
338,
540,
367
],
[
544,
337,
644,
367
],
[
650,
337,
687,
366
],
[
691,
336,
782,
366
],
[
185,
378,
200,
392
],
[
185,
445,
198,
460
],
[
164,
479,
184,
634
],
[
186,
514,
196,
528
],
[
689,
508,
721,
539
],
[
725,
509,
740,
539
],
[
745,
509,
840,
539
],
[
845,
509,
897,
539
],
[
707,
546,
811,
576
],
[
815,
546,
880,
576
],
[
185,
642,
200,
660
],
[
187,
716,
198,
728
],
[
119,
827,
125,
838
],
[
125,
825,
141,
837
],
[
120,
879,
152,
893
],
[
424,
880,
465,
895
],
[
467,
881,
518,
895
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[
120,
895,
135,
907
],
[
138,
895,
200,
908
],
[
422,
895,
465,
909
],
[
467,
895,
474,
909
],
[
477,
895,
500,
909
],
[
501,
896,
513,
910
],
[
515,
895,
533,
910
],
[
535,
895,
553,
910
],
[
555,
895,
598,
910
],
[
289,
976,
340,
996
],
[
343,
974,
712,
996
]
] | What is the conclusion obtained from the graph? | All 3 segments have consistent needs |
556 | [
"(2)",
"The",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"properly",
"store,",
"and",
"dispose",
"of,",
"any",
"stored",
"documents",
"assigned,",
"and",
"properly",
"store",
"any",
"records",
"relevant",
"to",
"those",
"storage",
"and",
"disposal.",
"(3)",
"In",
"case",
"the",
"document",
"storage",
"functions",
"are",
"reorganized",
"or",
"abolished",
"due",
"to",
"organizational",
"changes,",
"etc.,",
"the",
"core",
"organizations",
"taking",
"over",
"the",
"document-related",
"operations",
"shall",
"continue",
"to",
"store",
"the",
"documents",
"and",
"retain",
"the",
"disposal",
"records.",
"Chapter",
"3",
"Document",
"Storage",
"Period",
"Article",
"7",
"(Document",
"Storage",
"Period)",
"The",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"establish",
"storage",
"periods",
"for",
"different",
"types",
"of",
"assigned",
"documents,",
"by",
"checking",
"opinions",
"of",
"the",
"relevant",
"internal",
"functions,",
"if",
"necessary,",
"and",
"distinguish",
"and",
"designate",
"the",
"periods,",
"in",
"principle,",
"as",
"indicated",
"below.",
"However,",
"if",
"the",
"storage",
"periods",
"are",
"specified",
"by",
"laws,",
"regulations",
"or",
"Company",
"Regulations,",
"they",
"shall",
"be",
"established",
"in",
"compliance",
"with",
"those",
"laws,",
"regulations",
"and",
"Company",
"Regulations.",
"The",
"starting",
"point",
"for",
"determining",
"a",
"storage",
"period",
"shall",
"be,",
"in",
"principle,",
"the",
"date",
"on",
"which",
"the",
"document",
"is",
"created.",
"1.",
"To",
"be",
"stored",
"permanently",
"2.",
"To",
"be",
"stored",
"for",
"ten",
"years",
"3.",
"To",
"be",
"stored",
"for",
"seven",
"years",
"4.",
"To",
"be",
"stored",
"for",
"five",
"years",
"5.",
"To",
"be",
"stored",
"for",
"three",
"years",
"6.",
"To",
"be",
"stored",
"for",
"one",
"year",
"7.",
"To",
"be",
"stored",
"for",
"less",
"than",
"one",
"year",
"(to",
"be",
"disposed",
"of",
"promptly",
"after",
"use)",
"(2)",
"If",
"a",
"document",
"turns",
"out",
"not",
"to",
"be",
"categorized",
"into",
"any",
"document",
"types",
"designated",
"for",
"specified",
"storage",
"periods,",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"establish",
"a",
"storage",
"period",
"for",
"the",
"new",
"document",
"type,",
"as",
"stipulated",
"in",
"the",
"preceding",
"paragraph.",
"(3)",
"Concerning",
"the",
"provisions",
"set",
"forth",
"in",
"Paragraph",
"I",
"above,",
"the",
"following",
"documents",
"shall",
"be",
"stored",
"permanently.",
"1.",
"Articles",
"of",
"Incorporation",
"and",
"Company",
"Regulations",
"2.",
"Important",
"documents",
"concerning",
"the",
"General",
"Meetings",
"of",
"Shareholders,",
"the",
"Board",
"of",
"Directors,",
"the",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"important",
"conferences.",
"3.",
"Important",
"documents",
"concerning",
"mid/long-range",
"management",
"policies",
"and",
"plans",
"4.",
"Important",
"documents",
"concerning",
"the",
"Company's",
"rights",
"and",
"duties,",
"including",
"important",
"contracts,",
"lawsuits,",
"registrations,",
"etc.",
"Important",
"documents",
"concerning",
"budgets,",
"account",
"settlements,",
"and",
"other",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAKJ-TPC-00000254",
"Source:",
"https://www.indup2378",
"0boats.ucsf.edu/docs/jpjf0226"
] | [
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720,
315,
780,
330
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350
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201,
335,
217,
350
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335,
285,
350
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288,
335,
366,
350
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370,
335,
389,
350
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392,
334,
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350
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349
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542,
349
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567,
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630,
349
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690,
349
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693,
335,
764,
349
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768,
335,
781,
349
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160,
355,
234,
369
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236,
355,
265,
369
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267,
355,
345,
369
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348,
355,
377,
369
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380,
355,
446,
369
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449,
355,
472,
369
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475,
355,
534,
369
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537,
355,
552,
369
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555,
355,
625,
369
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628,
355,
644,
369
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647,
355,
714,
369
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717,
355,
764,
369
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374,
231,
389
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234,
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246,
389
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249,
375,
272,
389
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375,
327,
389
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330,
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383,
389
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410,
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628,
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647,
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250,
408
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433,
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448
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433,
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432,
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432,
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432,
386,
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390,
432,
459,
448
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462,
433,
474,
448
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478,
433,
532,
448
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164,
453,
181,
466
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[
198,
451,
215,
466
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[
219,
452,
238,
466
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[
241,
453,
285,
467
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289,
453,
379,
467
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473,
181,
486
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197,
471,
215,
486
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219,
471,
238,
486
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471,
284,
487
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288,
472,
310,
487
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472,
336,
487
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472,
377,
487
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490,
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505
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491,
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505
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491,
237,
505
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492,
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506
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492,
310,
506
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492,
355,
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492,
397,
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512,
285,
525
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512,
310,
525
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512,
341,
526
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345,
512,
385,
526
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529,
182,
545
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530,
215,
545
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219,
531,
237,
545
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532,
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546
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532,
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546
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312,
533,
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546
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532,
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545
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550,
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563
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565
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565
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566
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553,
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566
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553,
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566
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343,
553,
374,
565
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161,
568,
182,
583
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198,
570,
215,
584
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[
219,
570,
238,
585
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241,
570,
285,
585
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288,
571,
309,
585
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[
312,
571,
340,
586
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571,
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586
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378,
571,
405,
586
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408,
571,
440,
586
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443,
571,
463,
586
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467,
571,
487,
586
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490,
571,
551,
586
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555,
571,
571,
586
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[
575,
571,
641,
586
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[
644,
571,
678,
586
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681,
571,
711,
586
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130,
590,
157,
605
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[
160,
590,
172,
605
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591,
187,
605
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190,
591,
259,
605
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591,
298,
605
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301,
591,
325,
605
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329,
591,
352,
605
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591,
370,
605
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592,
391,
605
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394,
591,
477,
605
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481,
591,
511,
605
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514,
591,
542,
605
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545,
591,
614,
605
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618,
590,
659,
605
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662,
590,
737,
605
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740,
589,
765,
605
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161,
610,
224,
626
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] | mention the second point listed under the article 7(document storage period)? | To be stored for ten years |
557 | [
"3)",
"Other",
"places",
"designated",
"by",
"the",
"relevant",
"core",
"organizations",
".",
"\"Responsible",
"person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"a",
"core",
"organization.",
"5.",
"\"Person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"a",
"person",
"in",
"the",
"\"Line",
"Position\"",
"or",
"the",
"\"Quasi-Line",
"Position\",",
"as",
"stipulated",
"from",
"Article",
"41",
"1",
"through",
"Article",
"422",
"of",
"the",
"Business",
"Organization",
"Rule,",
"appointed",
"by",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage.",
"Article",
"4",
"(Principles",
"of",
"Creating",
"Documents)",
"Clerical",
"operations",
"shall",
"be",
"performed,",
"in",
"principle,",
"based",
"on",
"documents.",
"However,",
"efforts",
"shall",
"be",
"made",
"to",
"minimize",
"the",
"amount",
"of",
"documents",
"to",
"be",
"created.",
"Chapter",
"2",
"Document",
"Storage",
"Functions",
"Article",
"5",
"(Principles",
"concerning",
"Document",
"Storage",
"Functions",
")",
"In",
"principle,",
"for",
"documents",
"created",
"internally,",
"the",
"document",
"storage",
"functions",
"shall",
"be",
"the",
"core",
"organizations",
"in",
"charge",
"of",
"the",
"creation;",
"and",
"for",
"those",
"created",
"externally,",
"the",
"core",
"organizations",
"that",
"have",
"received",
"the",
"documents",
"shall",
"be",
"the",
"document",
"storage",
"functions.",
"However,",
"in",
"the",
"case",
"of",
"documents",
"created",
"internally,",
"if",
"the",
"receiving",
"core",
"organizations",
"are",
"designated",
"to",
"store",
"the",
"documents,",
"as",
"stipulated",
"by",
"laws,",
"regulations",
"or",
"Company",
"Regulations,",
"the",
"receiving",
"core",
"organizations",
"shall",
"be",
"the",
"document",
"storage",
"function.",
"(2)",
"Notwithstanding",
"the",
"preceding",
"paragraph,",
"materials",
"for",
"the",
"agenda",
"of",
"the",
"Board",
"of",
"Directors",
"and",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"conferences,",
"shall",
"be",
"stored",
"at",
"the",
"core",
"organizations",
"functioning",
"as",
"the",
"secretariats",
"for",
"the",
"conferences.",
"(3)",
"Documents",
"shall",
"be,",
"in",
"principle,",
"centrally",
"stored",
"at",
"the",
"document",
"storage",
"functions,",
"In",
"other",
"words,",
"functions",
"other",
"than",
"the",
"document",
"storage",
"functions",
"shall",
"not",
"store",
"the",
"relevant",
"documents,",
"and",
"shall",
"thus",
"dispose",
"of",
"any",
"documents",
"promptly",
"after",
"they",
"are",
"no",
"longer",
"necessary",
"(delete",
"any",
"electromagnetic",
"records;",
"the",
"same",
"shall",
"apply",
"to",
"the",
"rest",
"of",
"this",
"Policy)",
"Article",
"6",
"(Duties",
"of",
"Responsible",
"Person",
"in",
"Charge",
"of",
"Storage",
"and",
"Person",
"in",
"Charge",
"of",
"Storage",
"The",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"have",
"the",
"person",
"in",
"charge",
"of",
"storage",
"properly",
"store,",
"and",
"dispose",
"of,",
"any",
"stored",
"documents",
"in",
"the",
"relevant",
"core",
"organization,",
"and",
"ensure",
"that",
"any",
"relevant",
"subordinates",
"observe",
"this",
"Policy",
"and",
"the",
"Function",
"Standards",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAKJ-TPC-00000253",
"Source:",
"https://www.indup237800002ts.ucsf.edu/docs/jpjf0226"
] | [
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299,
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] | what is article 4? | (PRINCIPLES OF CREATING DOCUMENTS) |
580 | [
"Summary",
"of",
"Terms",
"for",
"OUS",
"Agreement",
"License",
"Exclusive",
"rights",
"in",
"approximately",
"60",
"countries",
"Semi",
"exclusive",
"rights",
"in",
"approximately",
"20",
"countries",
"Upfront",
"Fee",
"$20",
"million",
"signing",
"fee",
"with",
"$5",
"million",
"credible",
"to",
"Major",
"Europe",
"(Germany,",
"$2.0m;",
"UK,",
"$1.25;",
"France,",
"$1:0m,",
"Italy,",
"$0.75m)",
"Supply",
"Price",
"/",
"Royalty",
"Rate",
"30%",
"supply",
"price",
"Royalty",
"schedule",
"(based",
"on",
"half",
"year",
"sales)",
"Royalty",
"Rate",
"Year",
"1-3",
"Tiers",
"Year",
"4",
"onward",
"Tiers",
"5%",
"50",
"-",
"$85m",
"10",
"-",
"$170m",
"8%",
"$85m",
"-",
"$110m",
"$170m",
"-",
"$220m",
"14%",
">$110m",
"220m",
"Free",
"Goods",
"Year",
"Commercial",
"Free",
"Goods",
"Year",
"1",
"100%",
"30%",
"Year",
"2",
"100%",
"20%",
"Year",
"3",
"100%",
"10%",
"Overview",
"of",
"Major",
"Contract",
"Terms",
"Product",
"Liability",
"0(Lilly)/20",
"sharing",
"of",
"Serious",
"Adverse",
"Events",
"Takeda",
"Cap",
"at",
"$20Million",
"Minimum",
"Sales",
"20%",
"of",
"Lowest",
"Teir",
"($68",
"Million)",
"or",
"55%",
"of",
"rolling",
"one",
"year",
"forecast",
"Ability",
"to",
"lower",
"obligation",
"for",
"significant",
"event",
"Affiliate",
"Definition",
"Attempting",
"to",
"agree",
"on",
"a",
"proposal",
"which",
"prevents",
"Takeda",
"from",
"creating",
"local",
"JV",
"around",
"ACTOS",
"in",
"EU",
"Competing",
"Product",
"TZD",
"or",
"ISE",
"which",
"is",
"a",
"substitute",
"for",
"Pioglitazone",
"License",
"reverts",
"to",
"non-exclusive",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-RANSOM-00002624",
"Source:",
"https://www.indup5350-00002ts.ucsf.edu/docs/trjf0226"
] | [
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302,
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] | Semi exclusive rights in how many countries? | 20 |
557 | [
"3)",
"Other",
"places",
"designated",
"by",
"the",
"relevant",
"core",
"organizations",
".",
"\"Responsible",
"person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"a",
"core",
"organization.",
"5.",
"\"Person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"a",
"person",
"in",
"the",
"\"Line",
"Position\"",
"or",
"the",
"\"Quasi-Line",
"Position\",",
"as",
"stipulated",
"from",
"Article",
"41",
"1",
"through",
"Article",
"422",
"of",
"the",
"Business",
"Organization",
"Rule,",
"appointed",
"by",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage.",
"Article",
"4",
"(Principles",
"of",
"Creating",
"Documents)",
"Clerical",
"operations",
"shall",
"be",
"performed,",
"in",
"principle,",
"based",
"on",
"documents.",
"However,",
"efforts",
"shall",
"be",
"made",
"to",
"minimize",
"the",
"amount",
"of",
"documents",
"to",
"be",
"created.",
"Chapter",
"2",
"Document",
"Storage",
"Functions",
"Article",
"5",
"(Principles",
"concerning",
"Document",
"Storage",
"Functions",
")",
"In",
"principle,",
"for",
"documents",
"created",
"internally,",
"the",
"document",
"storage",
"functions",
"shall",
"be",
"the",
"core",
"organizations",
"in",
"charge",
"of",
"the",
"creation;",
"and",
"for",
"those",
"created",
"externally,",
"the",
"core",
"organizations",
"that",
"have",
"received",
"the",
"documents",
"shall",
"be",
"the",
"document",
"storage",
"functions.",
"However,",
"in",
"the",
"case",
"of",
"documents",
"created",
"internally,",
"if",
"the",
"receiving",
"core",
"organizations",
"are",
"designated",
"to",
"store",
"the",
"documents,",
"as",
"stipulated",
"by",
"laws,",
"regulations",
"or",
"Company",
"Regulations,",
"the",
"receiving",
"core",
"organizations",
"shall",
"be",
"the",
"document",
"storage",
"function.",
"(2)",
"Notwithstanding",
"the",
"preceding",
"paragraph,",
"materials",
"for",
"the",
"agenda",
"of",
"the",
"Board",
"of",
"Directors",
"and",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"conferences,",
"shall",
"be",
"stored",
"at",
"the",
"core",
"organizations",
"functioning",
"as",
"the",
"secretariats",
"for",
"the",
"conferences.",
"(3)",
"Documents",
"shall",
"be,",
"in",
"principle,",
"centrally",
"stored",
"at",
"the",
"document",
"storage",
"functions,",
"In",
"other",
"words,",
"functions",
"other",
"than",
"the",
"document",
"storage",
"functions",
"shall",
"not",
"store",
"the",
"relevant",
"documents,",
"and",
"shall",
"thus",
"dispose",
"of",
"any",
"documents",
"promptly",
"after",
"they",
"are",
"no",
"longer",
"necessary",
"(delete",
"any",
"electromagnetic",
"records;",
"the",
"same",
"shall",
"apply",
"to",
"the",
"rest",
"of",
"this",
"Policy)",
"Article",
"6",
"(Duties",
"of",
"Responsible",
"Person",
"in",
"Charge",
"of",
"Storage",
"and",
"Person",
"in",
"Charge",
"of",
"Storage",
"The",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"have",
"the",
"person",
"in",
"charge",
"of",
"storage",
"properly",
"store,",
"and",
"dispose",
"of,",
"any",
"stored",
"documents",
"in",
"the",
"relevant",
"core",
"organization,",
"and",
"ensure",
"that",
"any",
"relevant",
"subordinates",
"observe",
"this",
"Policy",
"and",
"the",
"Function",
"Standards",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAKJ-TPC-00000253",
"Source:",
"https://www.indup237800002ts.ucsf.edu/docs/jpjf0226"
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[
299,
980,
775,
997
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] | what is the title of chapter 2? | DOCUMENT STORAGE FUNCTIONS |
580 | [
"Summary",
"of",
"Terms",
"for",
"OUS",
"Agreement",
"License",
"Exclusive",
"rights",
"in",
"approximately",
"60",
"countries",
"Semi",
"exclusive",
"rights",
"in",
"approximately",
"20",
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"Upfront",
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"$20",
"million",
"signing",
"fee",
"with",
"$5",
"million",
"credible",
"to",
"Major",
"Europe",
"(Germany,",
"$2.0m;",
"UK,",
"$1.25;",
"France,",
"$1:0m,",
"Italy,",
"$0.75m)",
"Supply",
"Price",
"/",
"Royalty",
"Rate",
"30%",
"supply",
"price",
"Royalty",
"schedule",
"(based",
"on",
"half",
"year",
"sales)",
"Royalty",
"Rate",
"Year",
"1-3",
"Tiers",
"Year",
"4",
"onward",
"Tiers",
"5%",
"50",
"-",
"$85m",
"10",
"-",
"$170m",
"8%",
"$85m",
"-",
"$110m",
"$170m",
"-",
"$220m",
"14%",
">$110m",
"220m",
"Free",
"Goods",
"Year",
"Commercial",
"Free",
"Goods",
"Year",
"1",
"100%",
"30%",
"Year",
"2",
"100%",
"20%",
"Year",
"3",
"100%",
"10%",
"Overview",
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"Terms",
"Product",
"Liability",
"0(Lilly)/20",
"sharing",
"of",
"Serious",
"Adverse",
"Events",
"Takeda",
"Cap",
"at",
"$20Million",
"Minimum",
"Sales",
"20%",
"of",
"Lowest",
"Teir",
"($68",
"Million)",
"or",
"55%",
"of",
"rolling",
"one",
"year",
"forecast",
"Ability",
"to",
"lower",
"obligation",
"for",
"significant",
"event",
"Affiliate",
"Definition",
"Attempting",
"to",
"agree",
"on",
"a",
"proposal",
"which",
"prevents",
"Takeda",
"from",
"creating",
"local",
"JV",
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"ACTOS",
"in",
"EU",
"Competing",
"Product",
"TZD",
"or",
"ISE",
"which",
"is",
"a",
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"for",
"Pioglitazone",
"License",
"reverts",
"to",
"non-exclusive",
"2",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-RANSOM-00002624",
"Source:",
"https://www.indup5350-00002ts.ucsf.edu/docs/trjf0226"
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997
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302,
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] | What percent is the Supply Price / Royalty Rate? | 30% SUPPLY PRICE |
557 | [
"3)",
"Other",
"places",
"designated",
"by",
"the",
"relevant",
"core",
"organizations",
".",
"\"Responsible",
"person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"a",
"core",
"organization.",
"5.",
"\"Person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"a",
"person",
"in",
"the",
"\"Line",
"Position\"",
"or",
"the",
"\"Quasi-Line",
"Position\",",
"as",
"stipulated",
"from",
"Article",
"41",
"1",
"through",
"Article",
"422",
"of",
"the",
"Business",
"Organization",
"Rule,",
"appointed",
"by",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage.",
"Article",
"4",
"(Principles",
"of",
"Creating",
"Documents)",
"Clerical",
"operations",
"shall",
"be",
"performed,",
"in",
"principle,",
"based",
"on",
"documents.",
"However,",
"efforts",
"shall",
"be",
"made",
"to",
"minimize",
"the",
"amount",
"of",
"documents",
"to",
"be",
"created.",
"Chapter",
"2",
"Document",
"Storage",
"Functions",
"Article",
"5",
"(Principles",
"concerning",
"Document",
"Storage",
"Functions",
")",
"In",
"principle,",
"for",
"documents",
"created",
"internally,",
"the",
"document",
"storage",
"functions",
"shall",
"be",
"the",
"core",
"organizations",
"in",
"charge",
"of",
"the",
"creation;",
"and",
"for",
"those",
"created",
"externally,",
"the",
"core",
"organizations",
"that",
"have",
"received",
"the",
"documents",
"shall",
"be",
"the",
"document",
"storage",
"functions.",
"However,",
"in",
"the",
"case",
"of",
"documents",
"created",
"internally,",
"if",
"the",
"receiving",
"core",
"organizations",
"are",
"designated",
"to",
"store",
"the",
"documents,",
"as",
"stipulated",
"by",
"laws,",
"regulations",
"or",
"Company",
"Regulations,",
"the",
"receiving",
"core",
"organizations",
"shall",
"be",
"the",
"document",
"storage",
"function.",
"(2)",
"Notwithstanding",
"the",
"preceding",
"paragraph,",
"materials",
"for",
"the",
"agenda",
"of",
"the",
"Board",
"of",
"Directors",
"and",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"conferences,",
"shall",
"be",
"stored",
"at",
"the",
"core",
"organizations",
"functioning",
"as",
"the",
"secretariats",
"for",
"the",
"conferences.",
"(3)",
"Documents",
"shall",
"be,",
"in",
"principle,",
"centrally",
"stored",
"at",
"the",
"document",
"storage",
"functions,",
"In",
"other",
"words,",
"functions",
"other",
"than",
"the",
"document",
"storage",
"functions",
"shall",
"not",
"store",
"the",
"relevant",
"documents,",
"and",
"shall",
"thus",
"dispose",
"of",
"any",
"documents",
"promptly",
"after",
"they",
"are",
"no",
"longer",
"necessary",
"(delete",
"any",
"electromagnetic",
"records;",
"the",
"same",
"shall",
"apply",
"to",
"the",
"rest",
"of",
"this",
"Policy)",
"Article",
"6",
"(Duties",
"of",
"Responsible",
"Person",
"in",
"Charge",
"of",
"Storage",
"and",
"Person",
"in",
"Charge",
"of",
"Storage",
"The",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"have",
"the",
"person",
"in",
"charge",
"of",
"storage",
"properly",
"store,",
"and",
"dispose",
"of,",
"any",
"stored",
"documents",
"in",
"the",
"relevant",
"core",
"organization,",
"and",
"ensure",
"that",
"any",
"relevant",
"subordinates",
"observe",
"this",
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] | What does article 5 in this document describes? | (principles concerning document storage functions) |
557 | [
"3)",
"Other",
"places",
"designated",
"by",
"the",
"relevant",
"core",
"organizations",
".",
"\"Responsible",
"person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"a",
"core",
"organization.",
"5.",
"\"Person",
"in",
"charge",
"of",
"storage\"",
"shall",
"mean",
"a",
"person",
"in",
"the",
"\"Line",
"Position\"",
"or",
"the",
"\"Quasi-Line",
"Position\",",
"as",
"stipulated",
"from",
"Article",
"41",
"1",
"through",
"Article",
"422",
"of",
"the",
"Business",
"Organization",
"Rule,",
"appointed",
"by",
"the",
"responsible",
"person",
"in",
"charge",
"of",
"storage.",
"Article",
"4",
"(Principles",
"of",
"Creating",
"Documents)",
"Clerical",
"operations",
"shall",
"be",
"performed,",
"in",
"principle,",
"based",
"on",
"documents.",
"However,",
"efforts",
"shall",
"be",
"made",
"to",
"minimize",
"the",
"amount",
"of",
"documents",
"to",
"be",
"created.",
"Chapter",
"2",
"Document",
"Storage",
"Functions",
"Article",
"5",
"(Principles",
"concerning",
"Document",
"Storage",
"Functions",
")",
"In",
"principle,",
"for",
"documents",
"created",
"internally,",
"the",
"document",
"storage",
"functions",
"shall",
"be",
"the",
"core",
"organizations",
"in",
"charge",
"of",
"the",
"creation;",
"and",
"for",
"those",
"created",
"externally,",
"the",
"core",
"organizations",
"that",
"have",
"received",
"the",
"documents",
"shall",
"be",
"the",
"document",
"storage",
"functions.",
"However,",
"in",
"the",
"case",
"of",
"documents",
"created",
"internally,",
"if",
"the",
"receiving",
"core",
"organizations",
"are",
"designated",
"to",
"store",
"the",
"documents,",
"as",
"stipulated",
"by",
"laws,",
"regulations",
"or",
"Company",
"Regulations,",
"the",
"receiving",
"core",
"organizations",
"shall",
"be",
"the",
"document",
"storage",
"function.",
"(2)",
"Notwithstanding",
"the",
"preceding",
"paragraph,",
"materials",
"for",
"the",
"agenda",
"of",
"the",
"Board",
"of",
"Directors",
"and",
"Management",
"and",
"Operations",
"Committee,",
"and",
"other",
"conferences,",
"shall",
"be",
"stored",
"at",
"the",
"core",
"organizations",
"functioning",
"as",
"the",
"secretariats",
"for",
"the",
"conferences.",
"(3)",
"Documents",
"shall",
"be,",
"in",
"principle,",
"centrally",
"stored",
"at",
"the",
"document",
"storage",
"functions,",
"In",
"other",
"words,",
"functions",
"other",
"than",
"the",
"document",
"storage",
"functions",
"shall",
"not",
"store",
"the",
"relevant",
"documents,",
"and",
"shall",
"thus",
"dispose",
"of",
"any",
"documents",
"promptly",
"after",
"they",
"are",
"no",
"longer",
"necessary",
"(delete",
"any",
"electromagnetic",
"records;",
"the",
"same",
"shall",
"apply",
"to",
"the",
"rest",
"of",
"this",
"Policy)",
"Article",
"6",
"(Duties",
"of",
"Responsible",
"Person",
"in",
"Charge",
"of",
"Storage",
"and",
"Person",
"in",
"Charge",
"of",
"Storage",
"The",
"responsible",
"person",
"in",
"charge",
"of",
"storage",
"shall",
"have",
"the",
"person",
"in",
"charge",
"of",
"storage",
"properly",
"store,",
"and",
"dispose",
"of,",
"any",
"stored",
"documents",
"in",
"the",
"relevant",
"core",
"organization,",
"and",
"ensure",
"that",
"any",
"relevant",
"subordinates",
"observe",
"this",
"Policy",
"and",
"the",
"Function",
"Standards",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"TAKJ-TPC-00000253",
"Source:",
"https://www.indup237800002ts.ucsf.edu/docs/jpjf0226"
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] | When was expert advisory meeting ? | 4 OCTOBER 2006 |
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345,
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"Source:",
"https://www.industry@6209tents.ucsf.edu/docs/hfkf0226",
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] | What study is described in the table given? | Glycemic Parameters in a 26-Week Placebo-Controlled Dose-Ranging Study. |
605 | [
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] | Which parameters are considered for the study(see heading of table 2)? | Glycemic Parameters |
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582 | [
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579 | [
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583 | [
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620 | [
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620 | [
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583 | [
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584 | [
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"of",
"30.00%",
"Merck's",
"BMS'",
"PPAR's",
"PPAR's",
"Q3",
"2005",
"20.00%",
"Feb",
"2005",
"10.00%",
"0.00%",
"n-00",
"Apr-00",
"1-00",
"t-00",
"Jan",
"Apr-01",
"Jul-01",
"Apr-02",
"11-02",
"t-02",
"Jul-03",
"Jan-04",
"Apr-04",
"Jul-04",
"Jan-05",
"Apr-05",
"Jul-05",
"Oct",
"Jan-01",
"Oct",
"Jan-02",
"Jan-03",
"Apr-03",
"Oct-03",
"Oct-04",
"Oct-05",
"2000",
"2001",
"200",
"200",
"2004",
"2005",
"TZDs",
"TRx",
"(000s",
"10,577",
"14,681",
"17,",
"101",
"19,",
"407",
"21,479",
"22,902",
"Actos",
"TRx",
"(000s)",
"4,261",
"6,872",
"8,582",
"9,497",
"10,",
"149",
"10,472",
"TZD",
"Share",
"40.3%",
"46.8%",
"50.2%",
"49.0%",
"47.3%",
"45.7%",
"Plan",
"TZD",
"Share",
"n/a",
"n/a",
"7/a",
"46.",
"1%",
"42.9%",
"Forecast",
"as",
"a",
"%",
"of",
"Plan",
"n/a",
"n/a",
"na",
"106.3%",
"110.1%",
"AUTO>",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-HOVENR-00001898",
"Produced",
"in",
"MDL",
"on",
"02/27/13",
"Source:",
"https://www.induposciscoooo4ts.ucsf.edu/docs/ynjf0226"
] | [
[
108,
90,
221,
137
],
[
234,
89,
351,
138
],
[
362,
89,
411,
138
],
[
417,
89,
516,
138
],
[
106,
197,
156,
220
],
[
160,
196,
195,
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],
[
198,
196,
247,
220
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[
250,
196,
284,
220
],
[
289,
196,
342,
221
],
[
155,
235,
205,
252
],
[
366,
260,
430,
285
],
[
647,
264,
738,
289
],
[
155,
292,
200,
311
],
[
155,
349,
205,
366
],
[
615,
369,
669,
389
],
[
673,
369,
687,
389
],
[
753,
371,
807,
391
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[
811,
370,
827,
391
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[
155,
408,
201,
426
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[
622,
394,
680,
414
],
[
741,
394,
780,
414
],
[
783,
394,
840,
415
],
[
623,
415,
677,
435
],
[
759,
430,
782,
448
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[
785,
430,
818,
448
],
[
156,
466,
202,
484
],
[
617,
452,
646,
471
],
[
649,
452,
684,
471
],
[
156,
523,
205,
541
],
[
164,
583,
202,
599
],
[
193,
604,
218,
634
],
[
210,
605,
244,
646
],
[
245,
604,
266,
632
],
[
267,
605,
289,
633
],
[
185,
620,
208,
647
],
[
304,
604,
336,
648
],
[
331,
607,
359,
644
],
[
401,
605,
435,
648
],
[
432,
604,
456,
635
],
[
458,
605,
480,
633
],
[
522,
604,
552,
645
],
[
567,
605,
601,
648
],
[
592,
604,
626,
646
],
[
618,
604,
647,
645
],
[
662,
604,
694,
649
],
[
687,
603,
720,
649
],
[
713,
605,
741,
644
],
[
256,
621,
276,
647
],
[
280,
607,
313,
648
],
[
354,
624,
372,
648
],
[
376,
608,
409,
648
],
[
470,
607,
503,
647
],
[
496,
605,
527,
649
],
[
543,
607,
574,
648
],
[
638,
605,
670,
649
],
[
735,
605,
765,
649
],
[
410,
664,
437,
681
],
[
480,
664,
507,
682
],
[
550,
664,
573,
682
],
[
620,
665,
643,
683
],
[
690,
664,
715,
681
],
[
759,
663,
785,
682
],
[
225,
687,
260,
705
],
[
263,
687,
289,
705
],
[
291,
687,
326,
706
],
[
405,
686,
444,
706
],
[
475,
687,
512,
705
],
[
545,
687,
562,
705
],
[
565,
687,
586,
705
],
[
614,
688,
631,
705
],
[
633,
686,
657,
705
],
[
682,
686,
727,
706
],
[
752,
688,
796,
705
],
[
225,
711,
264,
729
],
[
267,
713,
293,
729
],
[
295,
713,
334,
730
],
[
409,
710,
442,
728
],
[
477,
712,
513,
730
],
[
547,
712,
579,
729
],
[
618,
711,
650,
730
],
[
684,
712,
701,
729
],
[
703,
713,
724,
729
],
[
754,
714,
793,
730
],
[
225,
734,
249,
752
],
[
255,
735,
291,
752
],
[
406,
734,
446,
751
],
[
475,
735,
517,
751
],
[
545,
735,
586,
752
],
[
614,
735,
655,
751
],
[
685,
734,
725,
751
],
[
755,
735,
792,
751
],
[
225,
759,
255,
778
],
[
259,
759,
283,
778
],
[
286,
759,
325,
777
],
[
415,
760,
434,
777
],
[
485,
760,
506,
778
],
[
558,
762,
575,
778
],
[
615,
759,
633,
777
],
[
635,
759,
651,
777
],
[
684,
758,
724,
777
],
[
224,
782,
282,
800
],
[
285,
783,
301,
800
],
[
305,
783,
314,
800
],
[
322,
783,
331,
800
],
[
333,
782,
346,
800
],
[
348,
781,
378,
800
],
[
414,
783,
435,
801
],
[
485,
783,
502,
799
],
[
555,
783,
574,
800
],
[
612,
783,
659,
800
],
[
681,
782,
730,
800
],
[
111,
834,
142,
846
],
[
47,
919,
103,
936
],
[
106,
920,
114,
936
],
[
116,
920,
153,
935
],
[
155,
920,
165,
935
],
[
167,
920,
218,
936
],
[
220,
919,
250,
936
],
[
792,
920,
917,
936
],
[
793,
939,
845,
956
],
[
848,
940,
859,
955
],
[
861,
940,
888,
956
],
[
890,
940,
905,
956
],
[
908,
940,
958,
957
],
[
288,
976,
340,
996
],
[
342,
974,
712,
997
]
] | what is the percentage of TZD share in the year 2000 ? | 40.3% |
584 | [
"Actos",
"Share",
"of",
"TZDs",
"Retail",
"TRX",
"SOM,",
"IMS",
"Health",
"60.00%",
"Actual",
"Forecast",
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"40.00%",
"Launch",
"of",
"Launch",
"of",
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"Merck's",
"BMS'",
"PPAR's",
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"Q3",
"2005",
"20.00%",
"Feb",
"2005",
"10.00%",
"0.00%",
"n-00",
"Apr-00",
"1-00",
"t-00",
"Jan",
"Apr-01",
"Jul-01",
"Apr-02",
"11-02",
"t-02",
"Jul-03",
"Jan-04",
"Apr-04",
"Jul-04",
"Jan-05",
"Apr-05",
"Jul-05",
"Oct",
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"Oct",
"Jan-02",
"Jan-03",
"Apr-03",
"Oct-03",
"Oct-04",
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"200",
"200",
"2004",
"2005",
"TZDs",
"TRx",
"(000s",
"10,577",
"14,681",
"17,",
"101",
"19,",
"407",
"21,479",
"22,902",
"Actos",
"TRx",
"(000s)",
"4,261",
"6,872",
"8,582",
"9,497",
"10,",
"149",
"10,472",
"TZD",
"Share",
"40.3%",
"46.8%",
"50.2%",
"49.0%",
"47.3%",
"45.7%",
"Plan",
"TZD",
"Share",
"n/a",
"n/a",
"7/a",
"46.",
"1%",
"42.9%",
"Forecast",
"as",
"a",
"%",
"of",
"Plan",
"n/a",
"n/a",
"na",
"106.3%",
"110.1%",
"AUTO>",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-HOVENR-00001898",
"Produced",
"in",
"MDL",
"on",
"02/27/13",
"Source:",
"https://www.induposciscoooo4ts.ucsf.edu/docs/ynjf0226"
] | [
[
108,
90,
221,
137
],
[
234,
89,
351,
138
],
[
362,
89,
411,
138
],
[
417,
89,
516,
138
],
[
106,
197,
156,
220
],
[
160,
196,
195,
220
],
[
198,
196,
247,
220
],
[
250,
196,
284,
220
],
[
289,
196,
342,
221
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[
155,
235,
205,
252
],
[
366,
260,
430,
285
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[
647,
264,
738,
289
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[
155,
292,
200,
311
],
[
155,
349,
205,
366
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[
615,
369,
669,
389
],
[
673,
369,
687,
389
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[
753,
371,
807,
391
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[
811,
370,
827,
391
],
[
155,
408,
201,
426
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[
622,
394,
680,
414
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[
741,
394,
780,
414
],
[
783,
394,
840,
415
],
[
623,
415,
677,
435
],
[
759,
430,
782,
448
],
[
785,
430,
818,
448
],
[
156,
466,
202,
484
],
[
617,
452,
646,
471
],
[
649,
452,
684,
471
],
[
156,
523,
205,
541
],
[
164,
583,
202,
599
],
[
193,
604,
218,
634
],
[
210,
605,
244,
646
],
[
245,
604,
266,
632
],
[
267,
605,
289,
633
],
[
185,
620,
208,
647
],
[
304,
604,
336,
648
],
[
331,
607,
359,
644
],
[
401,
605,
435,
648
],
[
432,
604,
456,
635
],
[
458,
605,
480,
633
],
[
522,
604,
552,
645
],
[
567,
605,
601,
648
],
[
592,
604,
626,
646
],
[
618,
604,
647,
645
],
[
662,
604,
694,
649
],
[
687,
603,
720,
649
],
[
713,
605,
741,
644
],
[
256,
621,
276,
647
],
[
280,
607,
313,
648
],
[
354,
624,
372,
648
],
[
376,
608,
409,
648
],
[
470,
607,
503,
647
],
[
496,
605,
527,
649
],
[
543,
607,
574,
648
],
[
638,
605,
670,
649
],
[
735,
605,
765,
649
],
[
410,
664,
437,
681
],
[
480,
664,
507,
682
],
[
550,
664,
573,
682
],
[
620,
665,
643,
683
],
[
690,
664,
715,
681
],
[
759,
663,
785,
682
],
[
225,
687,
260,
705
],
[
263,
687,
289,
705
],
[
291,
687,
326,
706
],
[
405,
686,
444,
706
],
[
475,
687,
512,
705
],
[
545,
687,
562,
705
],
[
565,
687,
586,
705
],
[
614,
688,
631,
705
],
[
633,
686,
657,
705
],
[
682,
686,
727,
706
],
[
752,
688,
796,
705
],
[
225,
711,
264,
729
],
[
267,
713,
293,
729
],
[
295,
713,
334,
730
],
[
409,
710,
442,
728
],
[
477,
712,
513,
730
],
[
547,
712,
579,
729
],
[
618,
711,
650,
730
],
[
684,
712,
701,
729
],
[
703,
713,
724,
729
],
[
754,
714,
793,
730
],
[
225,
734,
249,
752
],
[
255,
735,
291,
752
],
[
406,
734,
446,
751
],
[
475,
735,
517,
751
],
[
545,
735,
586,
752
],
[
614,
735,
655,
751
],
[
685,
734,
725,
751
],
[
755,
735,
792,
751
],
[
225,
759,
255,
778
],
[
259,
759,
283,
778
],
[
286,
759,
325,
777
],
[
415,
760,
434,
777
],
[
485,
760,
506,
778
],
[
558,
762,
575,
778
],
[
615,
759,
633,
777
],
[
635,
759,
651,
777
],
[
684,
758,
724,
777
],
[
224,
782,
282,
800
],
[
285,
783,
301,
800
],
[
305,
783,
314,
800
],
[
322,
783,
331,
800
],
[
333,
782,
346,
800
],
[
348,
781,
378,
800
],
[
414,
783,
435,
801
],
[
485,
783,
502,
799
],
[
555,
783,
574,
800
],
[
612,
783,
659,
800
],
[
681,
782,
730,
800
],
[
111,
834,
142,
846
],
[
47,
919,
103,
936
],
[
106,
920,
114,
936
],
[
116,
920,
153,
935
],
[
155,
920,
165,
935
],
[
167,
920,
218,
936
],
[
220,
919,
250,
936
],
[
792,
920,
917,
936
],
[
793,
939,
845,
956
],
[
848,
940,
859,
955
],
[
861,
940,
888,
956
],
[
890,
940,
905,
956
],
[
908,
940,
958,
957
],
[
288,
976,
340,
996
],
[
342,
974,
712,
997
]
] | what is Actos TRx (000s) in the year 2003 ? | 9,497 |
575 | [
"Most",
"Significant",
"Adverse",
"Events",
"Risks",
"for",
"Pioglitazone",
"Risk",
"Onset",
"Reversibility",
"Clinical",
"Findings",
"Occurrence",
"of",
"ALT",
"Elevation",
"Within",
"2",
"months",
"Only",
"through",
"Drug",
"Placebo",
"Liver",
"Failure",
"Transplant",
"Rezulln",
"1.1",
"70",
"0.120.",
"ACTOS",
"0.26%",
"0.25%",
"Avandia",
"0.20%",
"0.20%",
"Cardiac",
"Hypertrophy",
"Unknown",
"Unknown",
"Observed",
"during",
"Preclinical",
"Studies",
"in",
"Rats",
".",
"No",
"cases",
"in",
"Humans",
"Unknown",
"Unknown",
"Observed",
"during",
"Bladder",
"Cancer",
"Preclinical",
"Studies",
"in",
"Rats",
".",
"No",
"cases",
"in",
"Humans",
"Edema",
"Within",
"Yes",
"Occurrence",
"of",
"Edema",
"12",
"months",
"Drug",
"Placebo",
"ACTOS",
"15.3%",
"7.0%",
"Summary",
"of",
"Litigation",
"Risk",
"in",
"the",
"OUS",
"Territories",
"Out",
"of",
"10,359",
"claims",
"on",
"the",
"Litigation",
"Support",
"System",
"database,",
"only",
"10",
"claims",
"have",
"arose",
"from",
"the",
"Territory",
"in",
"this",
"Agreement",
"Country",
"All",
"Claims",
"Drug",
"Claims",
"Australia",
"Saudi",
"Arabia",
"South",
"Africa",
"Spain",
"Sweden",
"Total",
"U",
"-",
"OO",
"-",
"W",
"4",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-RANSOM-00002626",
"Source:",
"https://www.indup5350",
"0oo04ts.ucsf.edu/docs/trjf0226"
] | [
[
246,
181,
293,
198
],
[
297,
181,
392,
198
],
[
396,
182,
469,
199
],
[
473,
182,
534,
199
],
[
538,
182,
588,
199
],
[
593,
182,
618,
199
],
[
622,
182,
735,
199
],
[
257,
231,
292,
243
],
[
402,
232,
447,
244
],
[
502,
232,
596,
246
],
[
645,
232,
701,
246
],
[
704,
233,
770,
247
],
[
618,
251,
682,
261
],
[
685,
251,
698,
261
],
[
699,
251,
724,
261
],
[
725,
251,
778,
261
],
[
408,
258,
444,
269
],
[
405,
270,
412,
280
],
[
415,
270,
459,
281
],
[
507,
261,
533,
272
],
[
535,
261,
574,
273
],
[
680,
264,
708,
272
],
[
728,
263,
775,
273
],
[
242,
271,
273,
282
],
[
275,
270,
321,
282
],
[
513,
273,
574,
285
],
[
618,
274,
659,
285
],
[
684,
276,
700,
283
],
[
702,
277,
713,
284
],
[
742,
276,
772,
285
],
[
618,
285,
661,
295
],
[
684,
285,
718,
294
],
[
741,
285,
776,
295
],
[
618,
297,
664,
306
],
[
683,
297,
718,
307
],
[
742,
296,
780,
306
],
[
243,
335,
289,
346
],
[
292,
336,
369,
348
],
[
403,
338,
456,
349
],
[
517,
339,
568,
350
],
[
634,
336,
689,
345
],
[
692,
336,
725,
346
],
[
632,
347,
691,
357
],
[
692,
347,
734,
357
],
[
736,
347,
748,
357
],
[
749,
347,
776,
358
],
[
623,
359,
630,
368
],
[
633,
359,
650,
368
],
[
653,
359,
687,
368
],
[
688,
359,
699,
368
],
[
702,
359,
748,
369
],
[
403,
392,
456,
403
],
[
517,
388,
570,
398
],
[
633,
385,
689,
395
],
[
693,
385,
725,
396
],
[
243,
393,
291,
405
],
[
294,
393,
338,
406
],
[
632,
397,
692,
407
],
[
694,
397,
735,
407
],
[
737,
397,
748,
407
],
[
750,
397,
777,
408
],
[
623,
408,
631,
418
],
[
633,
409,
651,
418
],
[
653,
409,
687,
418
],
[
689,
409,
700,
418
],
[
702,
409,
751,
419
],
[
243,
441,
287,
452
],
[
409,
437,
446,
448
],
[
533,
433,
554,
445
],
[
631,
435,
694,
445
],
[
696,
435,
708,
445
],
[
710,
434,
751,
445
],
[
402,
449,
415,
459
],
[
417,
449,
459,
461
],
[
691,
446,
719,
455
],
[
738,
446,
783,
456
],
[
628,
457,
671,
468
],
[
698,
458,
734,
468
],
[
753,
457,
784,
467
],
[
254,
565,
357,
583
],
[
361,
565,
382,
583
],
[
386,
564,
485,
583
],
[
489,
564,
536,
583
],
[
540,
564,
561,
583
],
[
566,
564,
601,
583
],
[
605,
564,
653,
583
],
[
659,
563,
766,
583
],
[
303,
606,
334,
622
],
[
338,
607,
357,
622
],
[
361,
607,
416,
623
],
[
421,
608,
474,
623
],
[
478,
609,
498,
623
],
[
502,
609,
529,
623
],
[
533,
609,
611,
623
],
[
615,
608,
681,
624
],
[
685,
607,
745,
624
],
[
307,
625,
387,
639
],
[
391,
625,
426,
639
],
[
431,
625,
452,
639
],
[
455,
625,
507,
639
],
[
511,
625,
553,
639
],
[
557,
625,
604,
639
],
[
608,
625,
642,
639
],
[
650,
625,
678,
639
],
[
305,
641,
372,
656
],
[
376,
641,
394,
656
],
[
397,
641,
426,
656
],
[
430,
641,
521,
656
],
[
275,
690,
348,
706
],
[
479,
690,
504,
705
],
[
507,
691,
570,
705
],
[
608,
691,
653,
706
],
[
657,
690,
720,
706
],
[
275,
723,
348,
738
],
[
275,
741,
324,
755
],
[
328,
742,
382,
756
],
[
275,
757,
325,
771
],
[
329,
758,
379,
771
],
[
276,
773,
322,
787
],
[
275,
789,
342,
803
],
[
277,
807,
320,
820
],
[
654,
811,
668,
818
],
[
654,
795,
668,
802
],
[
652,
761,
667,
785
],
[
651,
744,
667,
752
],
[
650,
728,
667,
735
],
[
918,
918,
929,
929
],
[
71,
955,
149,
968
],
[
152,
955,
162,
968
],
[
165,
955,
214,
968
],
[
217,
955,
230,
968
],
[
233,
955,
300,
968
],
[
303,
955,
344,
968
],
[
791,
955,
955,
968
],
[
230,
982,
298,
997
],
[
301,
982,
500,
998
],
[
503,
980,
771,
998
]
] | how much percent of drug quantity present in rezulin under the title of 'clinical findings'? | 1.7% |
584 | [
"Actos",
"Share",
"of",
"TZDs",
"Retail",
"TRX",
"SOM,",
"IMS",
"Health",
"60.00%",
"Actual",
"Forecast",
"50.00%",
"40.00%",
"Launch",
"of",
"Launch",
"of",
"30.00%",
"Merck's",
"BMS'",
"PPAR's",
"PPAR's",
"Q3",
"2005",
"20.00%",
"Feb",
"2005",
"10.00%",
"0.00%",
"n-00",
"Apr-00",
"1-00",
"t-00",
"Jan",
"Apr-01",
"Jul-01",
"Apr-02",
"11-02",
"t-02",
"Jul-03",
"Jan-04",
"Apr-04",
"Jul-04",
"Jan-05",
"Apr-05",
"Jul-05",
"Oct",
"Jan-01",
"Oct",
"Jan-02",
"Jan-03",
"Apr-03",
"Oct-03",
"Oct-04",
"Oct-05",
"2000",
"2001",
"200",
"200",
"2004",
"2005",
"TZDs",
"TRx",
"(000s",
"10,577",
"14,681",
"17,",
"101",
"19,",
"407",
"21,479",
"22,902",
"Actos",
"TRx",
"(000s)",
"4,261",
"6,872",
"8,582",
"9,497",
"10,",
"149",
"10,472",
"TZD",
"Share",
"40.3%",
"46.8%",
"50.2%",
"49.0%",
"47.3%",
"45.7%",
"Plan",
"TZD",
"Share",
"n/a",
"n/a",
"7/a",
"46.",
"1%",
"42.9%",
"Forecast",
"as",
"a",
"%",
"of",
"Plan",
"n/a",
"n/a",
"na",
"106.3%",
"110.1%",
"AUTO>",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-HOVENR-00001898",
"Produced",
"in",
"MDL",
"on",
"02/27/13",
"Source:",
"https://www.induposciscoooo4ts.ucsf.edu/docs/ynjf0226"
] | [
[
108,
90,
221,
137
],
[
234,
89,
351,
138
],
[
362,
89,
411,
138
],
[
417,
89,
516,
138
],
[
106,
197,
156,
220
],
[
160,
196,
195,
220
],
[
198,
196,
247,
220
],
[
250,
196,
284,
220
],
[
289,
196,
342,
221
],
[
155,
235,
205,
252
],
[
366,
260,
430,
285
],
[
647,
264,
738,
289
],
[
155,
292,
200,
311
],
[
155,
349,
205,
366
],
[
615,
369,
669,
389
],
[
673,
369,
687,
389
],
[
753,
371,
807,
391
],
[
811,
370,
827,
391
],
[
155,
408,
201,
426
],
[
622,
394,
680,
414
],
[
741,
394,
780,
414
],
[
783,
394,
840,
415
],
[
623,
415,
677,
435
],
[
759,
430,
782,
448
],
[
785,
430,
818,
448
],
[
156,
466,
202,
484
],
[
617,
452,
646,
471
],
[
649,
452,
684,
471
],
[
156,
523,
205,
541
],
[
164,
583,
202,
599
],
[
193,
604,
218,
634
],
[
210,
605,
244,
646
],
[
245,
604,
266,
632
],
[
267,
605,
289,
633
],
[
185,
620,
208,
647
],
[
304,
604,
336,
648
],
[
331,
607,
359,
644
],
[
401,
605,
435,
648
],
[
432,
604,
456,
635
],
[
458,
605,
480,
633
],
[
522,
604,
552,
645
],
[
567,
605,
601,
648
],
[
592,
604,
626,
646
],
[
618,
604,
647,
645
],
[
662,
604,
694,
649
],
[
687,
603,
720,
649
],
[
713,
605,
741,
644
],
[
256,
621,
276,
647
],
[
280,
607,
313,
648
],
[
354,
624,
372,
648
],
[
376,
608,
409,
648
],
[
470,
607,
503,
647
],
[
496,
605,
527,
649
],
[
543,
607,
574,
648
],
[
638,
605,
670,
649
],
[
735,
605,
765,
649
],
[
410,
664,
437,
681
],
[
480,
664,
507,
682
],
[
550,
664,
573,
682
],
[
620,
665,
643,
683
],
[
690,
664,
715,
681
],
[
759,
663,
785,
682
],
[
225,
687,
260,
705
],
[
263,
687,
289,
705
],
[
291,
687,
326,
706
],
[
405,
686,
444,
706
],
[
475,
687,
512,
705
],
[
545,
687,
562,
705
],
[
565,
687,
586,
705
],
[
614,
688,
631,
705
],
[
633,
686,
657,
705
],
[
682,
686,
727,
706
],
[
752,
688,
796,
705
],
[
225,
711,
264,
729
],
[
267,
713,
293,
729
],
[
295,
713,
334,
730
],
[
409,
710,
442,
728
],
[
477,
712,
513,
730
],
[
547,
712,
579,
729
],
[
618,
711,
650,
730
],
[
684,
712,
701,
729
],
[
703,
713,
724,
729
],
[
754,
714,
793,
730
],
[
225,
734,
249,
752
],
[
255,
735,
291,
752
],
[
406,
734,
446,
751
],
[
475,
735,
517,
751
],
[
545,
735,
586,
752
],
[
614,
735,
655,
751
],
[
685,
734,
725,
751
],
[
755,
735,
792,
751
],
[
225,
759,
255,
778
],
[
259,
759,
283,
778
],
[
286,
759,
325,
777
],
[
415,
760,
434,
777
],
[
485,
760,
506,
778
],
[
558,
762,
575,
778
],
[
615,
759,
633,
777
],
[
635,
759,
651,
777
],
[
684,
758,
724,
777
],
[
224,
782,
282,
800
],
[
285,
783,
301,
800
],
[
305,
783,
314,
800
],
[
322,
783,
331,
800
],
[
333,
782,
346,
800
],
[
348,
781,
378,
800
],
[
414,
783,
435,
801
],
[
485,
783,
502,
799
],
[
555,
783,
574,
800
],
[
612,
783,
659,
800
],
[
681,
782,
730,
800
],
[
111,
834,
142,
846
],
[
47,
919,
103,
936
],
[
106,
920,
114,
936
],
[
116,
920,
153,
935
],
[
155,
920,
165,
935
],
[
167,
920,
218,
936
],
[
220,
919,
250,
936
],
[
792,
920,
917,
936
],
[
793,
939,
845,
956
],
[
848,
940,
859,
955
],
[
861,
940,
888,
956
],
[
890,
940,
905,
956
],
[
908,
940,
958,
957
],
[
288,
976,
340,
996
],
[
342,
974,
712,
997
]
] | what is the percentage of plan TZD share in the year 2004 ? | 42.9% |
575 | [
"Most",
"Significant",
"Adverse",
"Events",
"Risks",
"for",
"Pioglitazone",
"Risk",
"Onset",
"Reversibility",
"Clinical",
"Findings",
"Occurrence",
"of",
"ALT",
"Elevation",
"Within",
"2",
"months",
"Only",
"through",
"Drug",
"Placebo",
"Liver",
"Failure",
"Transplant",
"Rezulln",
"1.1",
"70",
"0.120.",
"ACTOS",
"0.26%",
"0.25%",
"Avandia",
"0.20%",
"0.20%",
"Cardiac",
"Hypertrophy",
"Unknown",
"Unknown",
"Observed",
"during",
"Preclinical",
"Studies",
"in",
"Rats",
".",
"No",
"cases",
"in",
"Humans",
"Unknown",
"Unknown",
"Observed",
"during",
"Bladder",
"Cancer",
"Preclinical",
"Studies",
"in",
"Rats",
".",
"No",
"cases",
"in",
"Humans",
"Edema",
"Within",
"Yes",
"Occurrence",
"of",
"Edema",
"12",
"months",
"Drug",
"Placebo",
"ACTOS",
"15.3%",
"7.0%",
"Summary",
"of",
"Litigation",
"Risk",
"in",
"the",
"OUS",
"Territories",
"Out",
"of",
"10,359",
"claims",
"on",
"the",
"Litigation",
"Support",
"System",
"database,",
"only",
"10",
"claims",
"have",
"arose",
"from",
"the",
"Territory",
"in",
"this",
"Agreement",
"Country",
"All",
"Claims",
"Drug",
"Claims",
"Australia",
"Saudi",
"Arabia",
"South",
"Africa",
"Spain",
"Sweden",
"Total",
"U",
"-",
"OO",
"-",
"W",
"4",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-RANSOM-00002626",
"Source:",
"https://www.indup5350",
"0oo04ts.ucsf.edu/docs/trjf0226"
] | [
[
246,
181,
293,
198
],
[
297,
181,
392,
198
],
[
396,
182,
469,
199
],
[
473,
182,
534,
199
],
[
538,
182,
588,
199
],
[
593,
182,
618,
199
],
[
622,
182,
735,
199
],
[
257,
231,
292,
243
],
[
402,
232,
447,
244
],
[
502,
232,
596,
246
],
[
645,
232,
701,
246
],
[
704,
233,
770,
247
],
[
618,
251,
682,
261
],
[
685,
251,
698,
261
],
[
699,
251,
724,
261
],
[
725,
251,
778,
261
],
[
408,
258,
444,
269
],
[
405,
270,
412,
280
],
[
415,
270,
459,
281
],
[
507,
261,
533,
272
],
[
535,
261,
574,
273
],
[
680,
264,
708,
272
],
[
728,
263,
775,
273
],
[
242,
271,
273,
282
],
[
275,
270,
321,
282
],
[
513,
273,
574,
285
],
[
618,
274,
659,
285
],
[
684,
276,
700,
283
],
[
702,
277,
713,
284
],
[
742,
276,
772,
285
],
[
618,
285,
661,
295
],
[
684,
285,
718,
294
],
[
741,
285,
776,
295
],
[
618,
297,
664,
306
],
[
683,
297,
718,
307
],
[
742,
296,
780,
306
],
[
243,
335,
289,
346
],
[
292,
336,
369,
348
],
[
403,
338,
456,
349
],
[
517,
339,
568,
350
],
[
634,
336,
689,
345
],
[
692,
336,
725,
346
],
[
632,
347,
691,
357
],
[
692,
347,
734,
357
],
[
736,
347,
748,
357
],
[
749,
347,
776,
358
],
[
623,
359,
630,
368
],
[
633,
359,
650,
368
],
[
653,
359,
687,
368
],
[
688,
359,
699,
368
],
[
702,
359,
748,
369
],
[
403,
392,
456,
403
],
[
517,
388,
570,
398
],
[
633,
385,
689,
395
],
[
693,
385,
725,
396
],
[
243,
393,
291,
405
],
[
294,
393,
338,
406
],
[
632,
397,
692,
407
],
[
694,
397,
735,
407
],
[
737,
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521,
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756
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329,
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771
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276,
773,
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787
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654,
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744,
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752
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[
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728,
667,
735
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918,
918,
929,
929
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303,
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968
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791,
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955,
968
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230,
982,
298,
997
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[
301,
982,
500,
998
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503,
980,
771,
998
]
] | how much percent of placebo present in avandia alongside of the clinical findings? | 0.20% |
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288,
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340,
996
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342,
974,
712,
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[
684,
758,
724,
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[
224,
782,
282,
800
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[
285,
783,
301,
800
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[
305,
783,
314,
800
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[
322,
783,
331,
800
],
[
333,
782,
346,
800
],
[
348,
781,
378,
800
],
[
414,
783,
435,
801
],
[
485,
783,
502,
799
],
[
555,
783,
574,
800
],
[
612,
783,
659,
800
],
[
681,
782,
730,
800
],
[
111,
834,
142,
846
],
[
47,
919,
103,
936
],
[
106,
920,
114,
936
],
[
116,
920,
153,
935
],
[
155,
920,
165,
935
],
[
167,
920,
218,
936
],
[
220,
919,
250,
936
],
[
792,
920,
917,
936
],
[
793,
939,
845,
956
],
[
848,
940,
859,
955
],
[
861,
940,
888,
956
],
[
890,
940,
905,
956
],
[
908,
940,
958,
957
],
[
288,
976,
340,
996
],
[
342,
974,
712,
997
]
] | what is the TZD's TRx (000s) in the year 2005 ? | 22,902 |
575 | [
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"Significant",
"Adverse",
"Events",
"Risks",
"for",
"Pioglitazone",
"Risk",
"Onset",
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"Clinical",
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"Transplant",
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"1.1",
"70",
"0.120.",
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"0.26%",
"0.25%",
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"0.20%",
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"Within",
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"12",
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"Arabia",
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"Africa",
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"U",
"-",
"OO",
"-",
"W",
"4",
"Confidential",
"-",
"Subject",
"to",
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"Order",
"LLY-RANSOM-00002626",
"Source:",
"https://www.indup5350",
"0oo04ts.ucsf.edu/docs/trjf0226"
] | [
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246,
181,
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[
297,
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396,
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538,
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588,
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257,
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778,
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258,
444,
269
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270,
412,
280
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415,
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459,
281
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507,
261,
533,
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535,
261,
574,
273
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680,
264,
708,
272
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728,
263,
775,
273
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242,
271,
273,
282
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275,
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321,
282
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513,
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700,
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702,
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713,
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618,
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684,
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285,
776,
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306
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683,
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306
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289,
346
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292,
336,
369,
348
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403,
338,
456,
349
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517,
339,
568,
350
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634,
336,
689,
345
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692,
336,
725,
346
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[
632,
347,
691,
357
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[
692,
347,
734,
357
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736,
347,
748,
357
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749,
347,
776,
358
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[
623,
359,
630,
368
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[
633,
359,
650,
368
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[
653,
359,
687,
368
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[
688,
359,
699,
368
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[
702,
359,
748,
369
],
[
403,
392,
456,
403
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[
517,
388,
570,
398
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[
633,
385,
689,
395
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[
693,
385,
725,
396
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243,
393,
291,
405
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294,
393,
338,
406
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632,
397,
692,
407
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694,
397,
735,
407
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737,
397,
748,
407
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750,
397,
777,
408
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418
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651,
418
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418
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689,
409,
700,
418
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702,
409,
751,
419
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243,
441,
287,
452
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409,
437,
446,
448
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533,
433,
554,
445
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631,
435,
694,
445
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696,
435,
708,
445
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710,
434,
751,
445
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402,
449,
415,
459
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[
417,
449,
459,
461
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691,
446,
719,
455
],
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738,
446,
783,
456
],
[
628,
457,
671,
468
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[
698,
458,
734,
468
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753,
457,
784,
467
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254,
565,
357,
583
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361,
565,
382,
583
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386,
564,
485,
583
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489,
564,
536,
583
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540,
564,
561,
583
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566,
564,
601,
583
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605,
564,
653,
583
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659,
563,
766,
583
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303,
606,
334,
622
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338,
607,
357,
622
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361,
607,
416,
623
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421,
608,
474,
623
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478,
609,
498,
623
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502,
609,
529,
623
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[
533,
609,
611,
623
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615,
608,
681,
624
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[
685,
607,
745,
624
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307,
625,
387,
639
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391,
625,
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639
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431,
625,
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639
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455,
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511,
625,
553,
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608,
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642,
639
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650,
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639
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305,
641,
372,
656
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376,
641,
394,
656
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397,
641,
426,
656
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430,
641,
521,
656
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275,
690,
348,
706
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479,
690,
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705
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507,
691,
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705
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608,
691,
653,
706
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657,
690,
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706
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275,
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348,
738
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275,
741,
324,
755
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328,
742,
382,
756
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275,
757,
325,
771
],
[
329,
758,
379,
771
],
[
276,
773,
322,
787
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[
275,
789,
342,
803
],
[
277,
807,
320,
820
],
[
654,
811,
668,
818
],
[
654,
795,
668,
802
],
[
652,
761,
667,
785
],
[
651,
744,
667,
752
],
[
650,
728,
667,
735
],
[
918,
918,
929,
929
],
[
71,
955,
149,
968
],
[
152,
955,
162,
968
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[
165,
955,
214,
968
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217,
955,
230,
968
],
[
233,
955,
300,
968
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[
303,
955,
344,
968
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[
791,
955,
955,
968
],
[
230,
982,
298,
997
],
[
301,
982,
500,
998
],
[
503,
980,
771,
998
]
] | what is the total number of all claims under the title of "summary of litigation risk in the ous territories"? | 10 |
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"on",
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"Source:",
"https://www.indupogg-0oogsts.ucsf.edu/docs/ynjf0226"
] | [
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95,
114,
262,
168
],
[
270,
113,
386,
168
],
[
393,
113,
419,
165
],
[
429,
113,
527,
163
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[
86,
224,
205,
261
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[
210,
224,
297,
261
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[
102,
306,
217,
341
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[
222,
305,
296,
341
],
[
299,
305,
332,
341
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[
336,
305,
378,
342
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[
381,
305,
440,
342
],
[
444,
305,
500,
342
],
[
509,
304,
648,
343
],
[
651,
304,
685,
343
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[
688,
304,
785,
343
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788,
304,
871,
343
],
[
118,
347,
256,
384
],
[
260,
346,
356,
385
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[
365,
345,
485,
385
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[
490,
345,
601,
385
],
[
606,
345,
693,
384
],
[
697,
345,
746,
382
],
[
751,
345,
852,
380
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367,
386,
548,
423
],
[
553,
385,
602,
422
],
[
85,
507,
184,
540
],
[
188,
508,
302,
541
],
[
308,
509,
406,
541
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88,
580,
114,
610
],
[
118,
580,
180,
611
],
[
185,
580,
295,
611
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[
299,
580,
364,
611
],
[
369,
580,
390,
611
],
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394,
579,
495,
612
],
[
499,
579,
523,
612
],
[
528,
579,
579,
612
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[
583,
579,
599,
612
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605,
578,
691,
612
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[
85,
647,
113,
677
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[
117,
647,
176,
677
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[
180,
647,
199,
677
],
[
203,
647,
237,
677
],
[
242,
647,
277,
678
],
[
282,
647,
323,
678
],
[
327,
647,
370,
679
],
[
375,
646,
428,
679
],
[
432,
646,
465,
679
],
[
469,
646,
520,
680
],
[
524,
646,
539,
680
],
[
542,
645,
628,
680
],
[
106,
834,
143,
848
],
[
46,
921,
103,
937
],
[
105,
922,
113,
937
],
[
115,
922,
152,
937
],
[
154,
922,
165,
937
],
[
167,
921,
217,
937
],
[
219,
920,
251,
937
],
[
792,
921,
916,
937
],
[
792,
940,
845,
958
],
[
847,
940,
859,
957
],
[
861,
940,
887,
958
],
[
890,
940,
905,
958
],
[
907,
939,
956,
959
],
[
288,
975,
341,
995
],
[
343,
973,
712,
996
]
] | what is the first TZD used for type 2 patients ? | ACTOS |
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"on",
"02/27/13",
"Source:",
"https://www.indupogg-0oogsts.ucsf.edu/docs/ynjf0226"
] | [
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95,
114,
262,
168
],
[
270,
113,
386,
168
],
[
393,
113,
419,
165
],
[
429,
113,
527,
163
],
[
86,
224,
205,
261
],
[
210,
224,
297,
261
],
[
102,
306,
217,
341
],
[
222,
305,
296,
341
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[
299,
305,
332,
341
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[
336,
305,
378,
342
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381,
305,
440,
342
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[
444,
305,
500,
342
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[
509,
304,
648,
343
],
[
651,
304,
685,
343
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[
688,
304,
785,
343
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[
788,
304,
871,
343
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118,
347,
256,
384
],
[
260,
346,
356,
385
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[
365,
345,
485,
385
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490,
345,
601,
385
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[
606,
345,
693,
384
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[
697,
345,
746,
382
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[
751,
345,
852,
380
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[
367,
386,
548,
423
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[
553,
385,
602,
422
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85,
507,
184,
540
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188,
508,
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541
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308,
509,
406,
541
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88,
580,
114,
610
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118,
580,
180,
611
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185,
580,
295,
611
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299,
580,
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611
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369,
580,
390,
611
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394,
579,
495,
612
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499,
579,
523,
612
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528,
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579,
612
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579,
599,
612
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605,
578,
691,
612
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85,
647,
113,
677
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117,
647,
176,
677
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180,
647,
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677
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203,
647,
237,
677
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242,
647,
277,
678
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282,
647,
323,
678
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327,
647,
370,
679
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[
375,
646,
428,
679
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432,
646,
465,
679
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469,
646,
520,
680
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524,
646,
539,
680
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542,
645,
628,
680
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106,
834,
143,
848
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921,
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937
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105,
922,
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937
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115,
922,
152,
937
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154,
922,
165,
937
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167,
921,
217,
937
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219,
920,
251,
937
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792,
921,
916,
937
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792,
940,
845,
958
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847,
940,
859,
957
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[
861,
940,
887,
958
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[
890,
940,
905,
958
],
[
907,
939,
956,
959
],
[
288,
975,
341,
995
],
[
343,
973,
712,
996
]
] | For which type of diabetes the TZD's prescribed earlier in treatment? | Type 2 diabetes |
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"prescribed",
"earlier",
"in",
"treatment",
"of",
"Type",
"2",
"diabetes",
"2.",
"Actos",
"is",
"the",
"the",
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"for",
"Type",
"2",
"patients.",
"<AUTO>",
"Confidential",
"-",
"Subject",
"to",
"Protective",
"Order",
"LLY-HOVENR-00001907",
"Produced",
"in",
"MDL",
"on",
"02/27/13",
"Source:",
"https://www.indupogg-0oogsts.ucsf.edu/docs/ynjf0226"
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] | what has to be establish as the the best OAD medication by treating insulin resistance ? | ACTOS |