bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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aim, prospective study, patent foramen ovale, contrast, risk factors, atherosclerosis, patients, ischemic, All, patients, neurological examination, NMR, transesophageal echocardiography, patent foramen ovale, patients, risk factors, atherosclerosis, patients, patent foramen ovale, age, hypertension, diabetes, use, oral contraceptives, atrial fibrillation, aneurysm, Multivariate analysis, risk factors, atherosclerosis, hypertension, diabetes, age, risk factors, patients, foramen ovale, patients, patent foramen ovale, use, oral contraceptives, risk factor, ischemic, Patients, ischemic, foramen ovale, age, patients, foramen ovale, frequency, hypertension, diabetes, patients, atrial fibrillation, Patients, patent foramen ovale, risk factors, atherosclerosis, use, oral contraceptives, aneurysm	IntensiveMedizin.80350607.eng.abstr_task2	Sentence: The aim of this prospective study was to assess the clinical and prognostic relevance of patent foramen ovale - in contrast to risk factors for atherosclerosis and cardioembolic sources - in 208 patients with cerebral ischemic events . All patients underwent neurological examination ( Doppler , CT , NMR ) as well as transthoracic and transesophageal echocardiography . A patent foramen ovale was found in 75 patients ( 36% ) . With regard to risk factors for atherosclerosis patients with closed resp. patent foramen ovale revealed significant differencies for age , hypertension , diabetes and use of oral contraceptives . Cardioembolic sources showed significant differencies for atrial fibrillation and atrial septal aneurysm . Multivariate analysis of risk factors for atherosclerosis and cardioembolic sources revealed hypertension and diabetes as age dependant risk factors in patients with closed foramen ovale . In patients with patent foramen ovale the use of oral contraceptives was found as an independant risk factor for cerebral ischemic event . Patients > 60 years with cerebral ischemic events had more often a closed foramen ovale . Dependant on age patients with closed foramen ovale showed a higher frequency of hypertension and diabetes . In addition these patients revealed more often atrial fibrillation . Patients with patent foramen ovale had fewer risk factors for atherosclerosis or cardioembolic sources but presented more frequent the use of oral contraceptives or atrial septal aneurysm . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	The aim of this prospective study was to assess the clinical and prognostic relevance of patent foramen ovale - in contrast to risk factors for atherosclerosis and cardioembolic sources - in 208 patients with cerebral ischemic events . All patients underwent neurological examination ( Doppler , CT , NMR ) as well as transthoracic and transesophageal echocardiography . A patent foramen ovale was found in 75 patients ( 36% ) . With regard to risk factors for atherosclerosis patients with closed resp. patent foramen ovale revealed significant differencies for age , hypertension , diabetes and use of oral contraceptives . Cardioembolic sources showed significant differencies for atrial fibrillation and atrial septal aneurysm . Multivariate analysis of risk factors for atherosclerosis and cardioembolic sources revealed hypertension and diabetes as age dependant risk factors in patients with closed foramen ovale . In patients with patent foramen ovale the use of oral contraceptives was found as an independant risk factor for cerebral ischemic event . Patients > 60 years with cerebral ischemic events had more often a closed foramen ovale . Dependant on age patients with closed foramen ovale showed a higher frequency of hypertension and diabetes . In addition these patients revealed more often atrial fibrillation . Patients with patent foramen ovale had fewer risk factors for atherosclerosis or cardioembolic sources but presented more frequent the use of oral contraceptives or atrial septal aneurysm .	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Physiology is an umlsterm, Health is an umlsterm, Evaluation is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, critically ill is an umlsterm, patients is an umlsterm, APACHE III is an umlsterm, Europe is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, ICU is an umlsterm, value is an umlsterm, hospital mortality is an umlsterm, Method is an umlsterm, patients is an umlsterm, APACHE II is an umlsterm, values is an umlsterm, survivors is an umlsterm, Mann - Whitney U test is an umlsterm, Receiver operating characteristics is an umlsterm, ROC analysis is an umlsterm, ROC curves is an umlsterm, patients is an umlsterm, hospital is an umlsterm, APACHE II is an umlsterm, ROC curve is an umlsterm, APACHE III is an umlsterm, APACHE II is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, value is an umlsterm, ICU is an umlsterm, patients is an umlsterm, APACHE III is an umlsterm, hospital mortality is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, Glasgow Coma Scale is an umlsterm	DerAnaesthesist.50440037.eng.abstr_task0	Sentence: The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]	The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements .	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Physiology is an umlsterm, Health is an umlsterm, Evaluation is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, critically ill is an umlsterm, patients is an umlsterm, APACHE III is an umlsterm, Europe is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, ICU is an umlsterm, value is an umlsterm, hospital mortality is an umlsterm, Method is an umlsterm, patients is an umlsterm, APACHE II is an umlsterm, values is an umlsterm, survivors is an umlsterm, Mann - Whitney U test is an umlsterm, Receiver operating characteristics is an umlsterm, ROC analysis is an umlsterm, ROC curves is an umlsterm, patients is an umlsterm, hospital is an umlsterm, APACHE II is an umlsterm, ROC curve is an umlsterm, APACHE III is an umlsterm, APACHE II is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, value is an umlsterm, ICU is an umlsterm, patients is an umlsterm, APACHE III is an umlsterm, hospital mortality is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, Glasgow Coma Scale is an umlsterm	DerAnaesthesist.50440037.eng.abstr_task1	Sentence: The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements . Instructions: please typing these entity words according to sentence: Physiology, Health, Evaluation, APACHE II, APACHE III, critically ill, patients, APACHE III, Europe, APACHE II, APACHE III, patients, intensive care unit, ICU, value, hospital mortality, Method, patients, APACHE II, values, survivors, Mann - Whitney U test, Receiver operating characteristics, ROC analysis, ROC curves, patients, hospital, APACHE II, ROC curve, APACHE III, APACHE II, APACHE II, APACHE III, value, ICU, patients, APACHE III, hospital mortality, APACHE II, APACHE III, Glasgow Coma Scale Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]	The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements .	[ "The", "Acute", "Physiology", "and", "Chronic", "Health", "Evaluation", "model", "(", "APACHE", "II", ",", "APACHE", "III", ")", "is", "used", "to", "describe", "the", "severity", "of", "illness", "and", "predict", "the", "outcome", "in", "critically", "ill", "patients", ".", "APACHE", "III", ",", "introduced", "in", "1991", ",", "has", "not", "yet", "been", "validated", "in", "Europe", ".", "We", "calculated", "APACHE", "II", "and", "APACHE", "III", "scores", "in", "patients", "after", "admission", "to", "the", "intensive", "care", "unit", "(", "ICU", ")", "and", "compared", "the", "prognostic", "value", "on", "hospital", "mortality", ".", "Method", ".", "One", "hundred", "fifty", "patients", "with", "stay", "of", "over", "24", "h", "were", "enrolled", "in", "the", "study", "and", "prospectively", "and", "consecutively", "investigated", ".", "APACHE", "II", "and", "III", "scores", "were", "calculated", "as", "described", "by", "the", "authors", ".", "The", "mean", "and", "median", "values", "of", "the", "survivors", "were", "compared", "with", "the", "non", "-", "surviving", "group", "(", "Mann", "-", "Whitney", "U", "test", ")", ".", "Receiver", "operating", "characteristics", "(", "ROC", "analysis", ")", "and", "the", "areas", "under", "the", "ROC", "curves", "were", "plotted", ".", "Results", ".", "Of", "the", "150", "patients", ",", "34", "died", "during", "their", "hospital", "stay", "(", "22.7", "%", ")", ".", "The", "mean", "and", "median", "APACHE", "II", "and", "III", "scores", "were", "significantly", "higher", "(", "P", "0.001", ")", "in", "the", "non", "-", "surviving", "group", ".", "The", "area", "under", "the", "ROC", "curve", "was", "higher", "for", "APACHE", "III", "(", "0.899", ")", "compared", "to", "APACHE", "II", "(", "0.847", ")", ".", "Conclusions", ".", "APACHE", "II", "and", "APACHE", "III", "were", "both", "found", "to", "have", "good", "prognostic", "value", "in", "general", "ICU", "patients", ".", "Our", "results", "suggest", "that", "the", "APACHE", "III", "version", "includes", "a", "more", "precise", "prediction", "of", "hospital", "mortality", "than", "APACHE", "II", ".", "A", "new", "aspect", "of", "APACHE", "III", "is", "an", "expanded", "modification", "of", "the", "Glasgow", "Coma", "Scale", "to", "assess", "neurologic", "derangements", "." ]	[ "umlsterm" ]
Physiology, Health, Evaluation, APACHE II, APACHE III, critically ill, patients, APACHE III, Europe, APACHE II, APACHE III, patients, intensive care unit, ICU, value, hospital mortality, Method, patients, APACHE II, values, survivors, Mann - Whitney U test, Receiver operating characteristics, ROC analysis, ROC curves, patients, hospital, APACHE II, ROC curve, APACHE III, APACHE II, APACHE II, APACHE III, value, ICU, patients, APACHE III, hospital mortality, APACHE II, APACHE III, Glasgow Coma Scale	DerAnaesthesist.50440037.eng.abstr_task2	Sentence: The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O" ]	The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements .	[ "The", "Acute", "Physiology", "and", "Chronic", "Health", "Evaluation", "model", "(", "APACHE", "II", ",", "APACHE", "III", ")", "is", "used", "to", "describe", "the", "severity", "of", "illness", "and", "predict", "the", "outcome", "in", "critically", "ill", "patients", ".", "APACHE", "III", ",", "introduced", "in", "1991", ",", "has", "not", "yet", "been", "validated", "in", "Europe", ".", "We", "calculated", "APACHE", "II", "and", "APACHE", "III", "scores", "in", "patients", "after", "admission", "to", "the", "intensive", "care", "unit", "(", "ICU", ")", "and", "compared", "the", "prognostic", "value", "on", "hospital", "mortality", ".", "Method", ".", "One", "hundred", "fifty", "patients", "with", "stay", "of", "over", "24", "h", "were", "enrolled", "in", "the", "study", "and", "prospectively", "and", "consecutively", "investigated", ".", "APACHE", "II", "and", "III", "scores", "were", "calculated", "as", "described", "by", "the", "authors", ".", "The", "mean", "and", "median", "values", "of", "the", "survivors", "were", "compared", "with", "the", "non", "-", "surviving", "group", "(", "Mann", "-", "Whitney", "U", "test", ")", ".", "Receiver", "operating", "characteristics", "(", "ROC", "analysis", ")", "and", "the", "areas", "under", "the", "ROC", "curves", "were", "plotted", ".", "Results", ".", "Of", "the", "150", "patients", ",", "34", "died", "during", "their", "hospital", "stay", "(", "22.7", "%", ")", ".", "The", "mean", "and", "median", "APACHE", "II", "and", "III", "scores", "were", "significantly", "higher", "(", "P", "0.001", ")", "in", "the", "non", "-", "surviving", "group", ".", "The", "area", "under", "the", "ROC", "curve", "was", "higher", "for", "APACHE", "III", "(", "0.899", ")", "compared", "to", "APACHE", "II", "(", "0.847", ")", ".", "Conclusions", ".", "APACHE", "II", "and", "APACHE", "III", "were", "both", "found", "to", "have", "good", "prognostic", "value", "in", "general", "ICU", "patients", ".", "Our", "results", "suggest", "that", "the", "APACHE", "III", "version", "includes", "a", "more", "precise", "prediction", "of", "hospital", "mortality", "than", "APACHE", "II", ".", "A", "new", "aspect", "of", "APACHE", "III", "is", "an", "expanded", "modification", "of", "the", "Glasgow", "Coma", "Scale", "to", "assess", "neurologic", "derangements", "." ]	[ "umlsterm" ]
dissection is an umlsterm, emergency situation is an umlsterm, diagnosis is an umlsterm, mortality is an umlsterm, chest pain is an umlsterm, Transesophageal echocardiography is an umlsterm, computed tomography is an umlsterm, magnetic resonance imaging is an umlsterm, aortography is an umlsterm, diagnostic is an umlsterm, dissection is an umlsterm, flap is an umlsterm, tears is an umlsterm, complications is an umlsterm, pleural effusions is an umlsterm, aortic insufficiency is an umlsterm, arteries is an umlsterm, Treatment is an umlsterm, hemodynamic is an umlsterm, systolic is an umlsterm, blood pressure is an umlsterm, stress is an umlsterm, dissections is an umlsterm, ascending aorta is an umlsterm, surgery is an umlsterm, dissections is an umlsterm, descending aorta is an umlsterm, surgical treatment is an umlsterm, hypertension is an umlsterm, dissection is an umlsterm, treatment is an umlsterm, patients is an umlsterm, dissections is an umlsterm, surgical is an umlsterm, risks is an umlsterm	IntensiveMedizin.80350593.eng.abstr_task0	Sentence: Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks .	[ "Acute", "aortic", "dissection", "is", "an", "emergency", "situation", ",", "and", "the", "diagnosis", "must", "be", "confirmed", "as", "soon", "as", "possible", "because", "of", "high", "early", "mortality", ".", "Severe", ",", "persistent", "chest", "pain", "of", "sudden", "onset", "is", "characteristic", ".", "Transesophageal", "echocardiography", ",", "computed", "tomography", ",", "magnetic", "resonance", "imaging", ",", "and", "aortography", "have", "comparable", "diagnostic", "accuracy", "with", "advantages", "and", "disadvantages", ",", "which", "are", "discussed", "in", "this", "overview", ".", "Echocardiography", "in", "aortic", "dissection", "can", "detect", "an", "intimal", "flap", ",", "intimal", "tears", ",", "the", "true", "and", "false", "lumen", ",", "complications", "such", "as", "pericardial", "and", "pleural", "effusions", ",", "aortic", "insufficiency", ",", "and", "involvement", "of", "the", "coronary", "arteries", ".", "Treatment", "includes", "the", "hemodynamic", "stabilization", ",", "simultaneous", "reduction", "of", "the", "systolic", "blood", "pressure", ",", "and", "reduction", "of", "the", "pulsatile", "aortic", "flow", "(", "shear", "stress", ")", ".", "All", "acute", "dissections", "involving", "the", "ascending", "aorta", "should", "be", "treated", "promptly", "with", "surgery", ".", "For", "dissections", "arising", "in", "the", "descending", "aorta", ",", "surgical", "treatment", "may", "be", "delayed", "until", "the", "hypertension", "and", "dissection", "have", "been", "stabilized", ".", "Permanent", "medical", "treatment", "may", "be", "offered", "in", "patients", "with", "type", "B", "dissections", "which", "tend", "to", "be", "poor", "surgical", "risks", "." ]	[ "umlsterm" ]
dissection is an umlsterm, emergency situation is an umlsterm, diagnosis is an umlsterm, mortality is an umlsterm, chest pain is an umlsterm, Transesophageal echocardiography is an umlsterm, computed tomography is an umlsterm, magnetic resonance imaging is an umlsterm, aortography is an umlsterm, diagnostic is an umlsterm, dissection is an umlsterm, flap is an umlsterm, tears is an umlsterm, complications is an umlsterm, pleural effusions is an umlsterm, aortic insufficiency is an umlsterm, arteries is an umlsterm, Treatment is an umlsterm, hemodynamic is an umlsterm, systolic is an umlsterm, blood pressure is an umlsterm, stress is an umlsterm, dissections is an umlsterm, ascending aorta is an umlsterm, surgery is an umlsterm, dissections is an umlsterm, descending aorta is an umlsterm, surgical treatment is an umlsterm, hypertension is an umlsterm, dissection is an umlsterm, treatment is an umlsterm, patients is an umlsterm, dissections is an umlsterm, surgical is an umlsterm, risks is an umlsterm	IntensiveMedizin.80350593.eng.abstr_task1	Sentence: Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks . Instructions: please typing these entity words according to sentence: dissection, emergency situation, diagnosis, mortality, chest pain, Transesophageal echocardiography, computed tomography, magnetic resonance imaging, aortography, diagnostic, dissection, flap, tears, complications, pleural effusions, aortic insufficiency, arteries, Treatment, hemodynamic, systolic, blood pressure, stress, dissections, ascending aorta, surgery, dissections, descending aorta, surgical treatment, hypertension, dissection, treatment, patients, dissections, surgical, risks Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks .	[ "Acute", "aortic", "dissection", "is", "an", "emergency", "situation", ",", "and", "the", "diagnosis", "must", "be", "confirmed", "as", "soon", "as", "possible", "because", "of", "high", "early", "mortality", ".", "Severe", ",", "persistent", "chest", "pain", "of", "sudden", "onset", "is", "characteristic", ".", "Transesophageal", "echocardiography", ",", "computed", "tomography", ",", "magnetic", "resonance", "imaging", ",", "and", "aortography", "have", "comparable", "diagnostic", "accuracy", "with", "advantages", "and", "disadvantages", ",", "which", "are", "discussed", "in", "this", "overview", ".", "Echocardiography", "in", "aortic", "dissection", "can", "detect", "an", "intimal", "flap", ",", "intimal", "tears", ",", "the", "true", "and", "false", "lumen", ",", "complications", "such", "as", "pericardial", "and", "pleural", "effusions", ",", "aortic", "insufficiency", ",", "and", "involvement", "of", "the", "coronary", "arteries", ".", "Treatment", "includes", "the", "hemodynamic", "stabilization", ",", "simultaneous", "reduction", "of", "the", "systolic", "blood", "pressure", ",", "and", "reduction", "of", "the", "pulsatile", "aortic", "flow", "(", "shear", "stress", ")", ".", "All", "acute", "dissections", "involving", "the", "ascending", "aorta", "should", "be", "treated", "promptly", "with", "surgery", ".", "For", "dissections", "arising", "in", "the", "descending", "aorta", ",", "surgical", "treatment", "may", "be", "delayed", "until", "the", "hypertension", "and", "dissection", "have", "been", "stabilized", ".", "Permanent", "medical", "treatment", "may", "be", "offered", "in", "patients", "with", "type", "B", "dissections", "which", "tend", "to", "be", "poor", "surgical", "risks", "." ]	[ "umlsterm" ]
dissection, emergency situation, diagnosis, mortality, chest pain, Transesophageal echocardiography, computed tomography, magnetic resonance imaging, aortography, diagnostic, dissection, flap, tears, complications, pleural effusions, aortic insufficiency, arteries, Treatment, hemodynamic, systolic, blood pressure, stress, dissections, ascending aorta, surgery, dissections, descending aorta, surgical treatment, hypertension, dissection, treatment, patients, dissections, surgical, risks	IntensiveMedizin.80350593.eng.abstr_task2	Sentence: Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks .	[ "Acute", "aortic", "dissection", "is", "an", "emergency", "situation", ",", "and", "the", "diagnosis", "must", "be", "confirmed", "as", "soon", "as", "possible", "because", "of", "high", "early", "mortality", ".", "Severe", ",", "persistent", "chest", "pain", "of", "sudden", "onset", "is", "characteristic", ".", "Transesophageal", "echocardiography", ",", "computed", "tomography", ",", "magnetic", "resonance", "imaging", ",", "and", "aortography", "have", "comparable", "diagnostic", "accuracy", "with", "advantages", "and", "disadvantages", ",", "which", "are", "discussed", "in", "this", "overview", ".", "Echocardiography", "in", "aortic", "dissection", "can", "detect", "an", "intimal", "flap", ",", "intimal", "tears", ",", "the", "true", "and", "false", "lumen", ",", "complications", "such", "as", "pericardial", "and", "pleural", "effusions", ",", "aortic", "insufficiency", ",", "and", "involvement", "of", "the", "coronary", "arteries", ".", "Treatment", "includes", "the", "hemodynamic", "stabilization", ",", "simultaneous", "reduction", "of", "the", "systolic", "blood", "pressure", ",", "and", "reduction", "of", "the", "pulsatile", "aortic", "flow", "(", "shear", "stress", ")", ".", "All", "acute", "dissections", "involving", "the", "ascending", "aorta", "should", "be", "treated", "promptly", "with", "surgery", ".", "For", "dissections", "arising", "in", "the", "descending", "aorta", ",", "surgical", "treatment", "may", "be", "delayed", "until", "the", "hypertension", "and", "dissection", "have", "been", "stabilized", ".", "Permanent", "medical", "treatment", "may", "be", "offered", "in", "patients", "with", "type", "B", "dissections", "which", "tend", "to", "be", "poor", "surgical", "risks", "." ]	[ "umlsterm" ]
fluoride is a Intervention_Pharmacological, chlorhexidine is a Intervention_Pharmacological, microflora of dental root surfaces is a Outcome_Physical, Forty - four patients , surgically treated for advanced periodontal disease is a Participant_Condition, control group is a Intervention_Control, Mutans streptococci on root surfaces were suppressed is a Outcome_Physical, increase in the number of Actinomyces viscosus / naeslundii is a Outcome_Physical, increase in the number of decayed and filled root surfaces is a Outcome_Physical, initial root - surface lesions had hardened is a Outcome_Physical	42844_task0	Sentence: Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Control, Intervention_Pharmacological, Outcome_Physical, Participant_Condition	[ "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O" ]	Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups .	[ "Effects", "of", "fluoride", "and", "chlorhexidine", "on", "the", "microflora", "of", "dental", "root", "surfaces", "and", "progression", "of", "root", "-", "surface", "caries", ".", "The", "effects", "of", "fluoride", "and", "chlorhexidine", "varnishes", "on", "the", "microflora", "of", "dental", "root", "surfaces", "and", "on", "the", "progression", "of", "root", "-", "surface", "caries", "were", "studied", ".", "Forty", "-", "four", "patients", ",", "surgically", "treated", "for", "advanced", "periodontal", "disease", ",", "were", "distributed", "at", "random", "among", "three", "groups", ".", "All", "patients", "received", "a", "standardized", "preventive", "treatment", ".", "Furthermore", ",", "the", "dentition", "of", "the", "patients", "in", "the", "two", "experimental", "groups", "was", "treated", ",", "at", "three", "-", "month", "intervals", ",", "with", "chlorhexidine", "and", "fluoride", "varnish", ",", "respectively", ".", "Patients", "in", "the", "control", "group", "received", "no", "additional", "treatment", ".", "In", "the", "experimental", "groups", ",", "plaque", "samples", "were", "collected", "from", "selected", "sound", "and", "carious", "root", "surfaces", "at", "baseline", "and", "at", "three", ",", "six", ",", "and", "nine", "months", "after", "the", "onset", "of", "the", "study", ".", "The", "presence", "of", "root", "-", "surface", "caries", "was", "scored", "at", "baseline", "and", "after", "one", "year", ".", "In", "addition", ",", "the", "texture", ",", "depth", ",", "and", "color", "of", "the", "root", "-", "surface", "lesions", "were", "monitored", ".", "Mutans", "streptococci", "on", "root", "surfaces", "were", "suppressed", "significantly", "(", "p", "less", "than", "0.05", ")", "during", "the", "whole", "experimental", "period", "in", "the", "chlorhexidine", "varnish", "group", ",", "but", "not", "in", "the", "fluoride", "varnish", "group", ".", "A", "non", "-", "significant", "increase", "in", "the", "number", "of", "Actinomyces", "viscosus", "/", "naeslundii", "was", "noted", "after", "treatment", "with", "chlorhexidine", "and", "fluoride", "varnish", ".", "The", "increase", "in", "the", "number", "of", "decayed", "and", "filled", "root", "surfaces", "after", "one", "year", "was", "significantly", "lower", "in", "the", "experimental", "groups", "than", "in", "the", "control", "group", ".", "After", "treatment", "with", "chlorhexidine", "varnish", ",", "significantly", "more", "initial", "root", "-", "surface", "lesions", "had", "hardened", "than", "in", "the", "other", "groups", "." ]	[ "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]
fluoride is a Intervention_Pharmacological, chlorhexidine is a Intervention_Pharmacological, microflora of dental root surfaces is a Outcome_Physical, Forty - four patients , surgically treated for advanced periodontal disease is a Participant_Condition, control group is a Intervention_Control, Mutans streptococci on root surfaces were suppressed is a Outcome_Physical, increase in the number of Actinomyces viscosus / naeslundii is a Outcome_Physical, increase in the number of decayed and filled root surfaces is a Outcome_Physical, initial root - surface lesions had hardened is a Outcome_Physical	42844_task1	Sentence: Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups . Instructions: please typing these entity words according to sentence: fluoride, chlorhexidine, microflora of dental root surfaces, Forty - four patients , surgically treated for advanced periodontal disease, control group, Mutans streptococci on root surfaces were suppressed, increase in the number of Actinomyces viscosus / naeslundii, increase in the number of decayed and filled root surfaces, initial root - surface lesions had hardened Options: Intervention_Control, Intervention_Pharmacological, Outcome_Physical, Participant_Condition	[ "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O" ]	Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups .	[ "Effects", "of", "fluoride", "and", "chlorhexidine", "on", "the", "microflora", "of", "dental", "root", "surfaces", "and", "progression", "of", "root", "-", "surface", "caries", ".", "The", "effects", "of", "fluoride", "and", "chlorhexidine", "varnishes", "on", "the", "microflora", "of", "dental", "root", "surfaces", "and", "on", "the", "progression", "of", "root", "-", "surface", "caries", "were", "studied", ".", "Forty", "-", "four", "patients", ",", "surgically", "treated", "for", "advanced", "periodontal", "disease", ",", "were", "distributed", "at", "random", "among", "three", "groups", ".", "All", "patients", "received", "a", "standardized", "preventive", "treatment", ".", "Furthermore", ",", "the", "dentition", "of", "the", "patients", "in", "the", "two", "experimental", "groups", "was", "treated", ",", "at", "three", "-", "month", "intervals", ",", "with", "chlorhexidine", "and", "fluoride", "varnish", ",", "respectively", ".", "Patients", "in", "the", "control", "group", "received", "no", "additional", "treatment", ".", "In", "the", "experimental", "groups", ",", "plaque", "samples", "were", "collected", "from", "selected", "sound", "and", "carious", "root", "surfaces", "at", "baseline", "and", "at", "three", ",", "six", ",", "and", "nine", "months", "after", "the", "onset", "of", "the", "study", ".", "The", "presence", "of", "root", "-", "surface", "caries", "was", "scored", "at", "baseline", "and", "after", "one", "year", ".", "In", "addition", ",", "the", "texture", ",", "depth", ",", "and", "color", "of", "the", "root", "-", "surface", "lesions", "were", "monitored", ".", "Mutans", "streptococci", "on", "root", "surfaces", "were", "suppressed", "significantly", "(", "p", "less", "than", "0.05", ")", "during", "the", "whole", "experimental", "period", "in", "the", "chlorhexidine", "varnish", "group", ",", "but", "not", "in", "the", "fluoride", "varnish", "group", ".", "A", "non", "-", "significant", "increase", "in", "the", "number", "of", "Actinomyces", "viscosus", "/", "naeslundii", "was", "noted", "after", "treatment", "with", "chlorhexidine", "and", "fluoride", "varnish", ".", "The", "increase", "in", "the", "number", "of", "decayed", "and", "filled", "root", "surfaces", "after", "one", "year", "was", "significantly", "lower", "in", "the", "experimental", "groups", "than", "in", "the", "control", "group", ".", "After", "treatment", "with", "chlorhexidine", "varnish", ",", "significantly", "more", "initial", "root", "-", "surface", "lesions", "had", "hardened", "than", "in", "the", "other", "groups", "." ]	[ "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]
fluoride, chlorhexidine, microflora of dental root surfaces, Forty - four patients , surgically treated for advanced periodontal disease, control group, Mutans streptococci on root surfaces were suppressed, increase in the number of Actinomyces viscosus / naeslundii, increase in the number of decayed and filled root surfaces, initial root - surface lesions had hardened	42844_task2	Sentence: Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O" ]	Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups .	[ "Effects", "of", "fluoride", "and", "chlorhexidine", "on", "the", "microflora", "of", "dental", "root", "surfaces", "and", "progression", "of", "root", "-", "surface", "caries", ".", "The", "effects", "of", "fluoride", "and", "chlorhexidine", "varnishes", "on", "the", "microflora", "of", "dental", "root", "surfaces", "and", "on", "the", "progression", "of", "root", "-", "surface", "caries", "were", "studied", ".", "Forty", "-", "four", "patients", ",", "surgically", "treated", "for", "advanced", "periodontal", "disease", ",", "were", "distributed", "at", "random", "among", "three", "groups", ".", "All", "patients", "received", "a", "standardized", "preventive", "treatment", ".", "Furthermore", ",", "the", "dentition", "of", "the", "patients", "in", "the", "two", "experimental", "groups", "was", "treated", ",", "at", "three", "-", "month", "intervals", ",", "with", "chlorhexidine", "and", "fluoride", "varnish", ",", "respectively", ".", "Patients", "in", "the", "control", "group", "received", "no", "additional", "treatment", ".", "In", "the", "experimental", "groups", ",", "plaque", "samples", "were", "collected", "from", "selected", "sound", "and", "carious", "root", "surfaces", "at", "baseline", "and", "at", "three", ",", "six", ",", "and", "nine", "months", "after", "the", "onset", "of", "the", "study", ".", "The", "presence", "of", "root", "-", "surface", "caries", "was", "scored", "at", "baseline", "and", "after", "one", "year", ".", "In", "addition", ",", "the", "texture", ",", "depth", ",", "and", "color", "of", "the", "root", "-", "surface", "lesions", "were", "monitored", ".", "Mutans", "streptococci", "on", "root", "surfaces", "were", "suppressed", "significantly", "(", "p", "less", "than", "0.05", ")", "during", "the", "whole", "experimental", "period", "in", "the", "chlorhexidine", "varnish", "group", ",", "but", "not", "in", "the", "fluoride", "varnish", "group", ".", "A", "non", "-", "significant", "increase", "in", "the", "number", "of", "Actinomyces", "viscosus", "/", "naeslundii", "was", "noted", "after", "treatment", "with", "chlorhexidine", "and", "fluoride", "varnish", ".", "The", "increase", "in", "the", "number", "of", "decayed", "and", "filled", "root", "surfaces", "after", "one", "year", "was", "significantly", "lower", "in", "the", "experimental", "groups", "than", "in", "the", "control", "group", ".", "After", "treatment", "with", "chlorhexidine", "varnish", ",", "significantly", "more", "initial", "root", "-", "surface", "lesions", "had", "hardened", "than", "in", "the", "other", "groups", "." ]	[ "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]
Weights and heights is an outcome	841_task0	Sentence: Weights and heights were measured at the tri-monthly treatment visits for a period of one year . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: outcome	[ "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Weights and heights were measured at the tri-monthly treatment visits for a period of one year .	[ "Weights", "and", "heights", "were", "measured", "at", "the", "tri", "-", "monthly", "treatment", "visits", "for", "a", "period", "of", "one", "year", "." ]	[ "outcome" ]
Weights and heights is an outcome	841_task1	Sentence: Weights and heights were measured at the tri-monthly treatment visits for a period of one year . Instructions: please typing these entity words according to sentence: Weights and heights Options: outcome	[ "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Weights and heights were measured at the tri-monthly treatment visits for a period of one year .	[ "Weights", "and", "heights", "were", "measured", "at", "the", "tri", "-", "monthly", "treatment", "visits", "for", "a", "period", "of", "one", "year", "." ]	[ "outcome" ]
Weights and heights	841_task2	Sentence: Weights and heights were measured at the tri-monthly treatment visits for a period of one year . Instructions: please extract entity words from the input sentence	[ "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Weights and heights were measured at the tri-monthly treatment visits for a period of one year .	[ "Weights", "and", "heights", "were", "measured", "at", "the", "tri", "-", "monthly", "treatment", "visits", "for", "a", "period", "of", "one", "year", "." ]	[ "outcome" ]
PKC is a protein, PMA is a compound, PKC is a protein	DS.d1322_task0	Sentence: 4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.	[ "4", ")", "PKA", "regulates", "neurotransmission", "without", "PKC", "involvement", "because", ",", "after", "PMA", "or", "CaC", "modulation", "of", "the", "PKC", "activity", ",", "coupling", "to", "the", "ACh", "release", "of", "PKA", "can", "normally", "be", "stimulated", "with", "Sp-8-BrcAMP", "or", "inhibited", "with", "H-89", "." ]	[ "compound", "protein" ]
PKC is a protein, PMA is a compound, PKC is a protein	DS.d1322_task1	Sentence: 4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89. Instructions: please typing these entity words according to sentence: PKC, PMA, PKC Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.	[ "4", ")", "PKA", "regulates", "neurotransmission", "without", "PKC", "involvement", "because", ",", "after", "PMA", "or", "CaC", "modulation", "of", "the", "PKC", "activity", ",", "coupling", "to", "the", "ACh", "release", "of", "PKA", "can", "normally", "be", "stimulated", "with", "Sp-8-BrcAMP", "or", "inhibited", "with", "H-89", "." ]	[ "compound", "protein" ]
PKC, PMA, PKC	DS.d1322_task2	Sentence: 4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.	[ "4", ")", "PKA", "regulates", "neurotransmission", "without", "PKC", "involvement", "because", ",", "after", "PMA", "or", "CaC", "modulation", "of", "the", "PKC", "activity", ",", "coupling", "to", "the", "ACh", "release", "of", "PKA", "can", "normally", "be", "stimulated", "with", "Sp-8-BrcAMP", "or", "inhibited", "with", "H-89", "." ]	[ "compound", "protein" ]
Primary ITP is a Condition, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l is a Scope, Age is a Person, 18 - 45 years is a Value, Previously treated is a Observation, failure is a Qualifier, intolerance is a Qualifier, first - line therapy is a Procedure, relapse is a Condition, after first - line therapy is a Temporal, corticosteroids is a Drug, intravenous immunoglobulin is a Drug, IVIG is a Drug, anti - D immunoglobulins is a Drug	NCT02760251_inc_task0	Sentence: Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Scope, Drug	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Qualifier", "O", "B-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O" ]	Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins	[ "Informed", "consent", "as", "documented", "by", "signature", "(", "see", "informed", "consent", "form", ")", "\n", "Primary", "ITP", "according", "to", "the", "definition", "of", "Rodeghiero", "et", "al", ".", "(", "52", ")", "and", "a", "platelet", "count", "of", "<", "30x109", "/", "l", "\n", "Age", "range", ":", "18", "-", "45", "years", "\n", "Previously", "treated", "patients", ",", "with", "failure", "or", "intolerance", "to", "first", "-", "line", "therapy", ",", "or", "relapse", "after", "first", "-", "line", "therapy", ",", "i.e", ".", "corticosteroids", ",", "intravenous", "immunoglobulin", "(", "IVIG", ")", ",", "or", "anti", "-", "D", "immunoglobulins", "\n" ]	[ "Scope", "Drug", "Measurement", "Temporal", "Observation", "Procedure", "Reference_point", "Condition", "Value", "Qualifier", "Person" ]
Primary ITP is a Condition, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l is a Scope, Age is a Person, 18 - 45 years is a Value, Previously treated is a Observation, failure is a Qualifier, intolerance is a Qualifier, first - line therapy is a Procedure, relapse is a Condition, after first - line therapy is a Temporal, corticosteroids is a Drug, intravenous immunoglobulin is a Drug, IVIG is a Drug, anti - D immunoglobulins is a Drug	NCT02760251_inc_task1	Sentence: Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins Instructions: please typing these entity words according to sentence: Primary ITP, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l, Age, 18 - 45 years, Previously treated, failure, intolerance, first - line therapy, relapse, after first - line therapy, corticosteroids, intravenous immunoglobulin, IVIG, anti - D immunoglobulins Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Scope, Drug	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Qualifier", "O", "B-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O" ]	Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins	[ "Informed", "consent", "as", "documented", "by", "signature", "(", "see", "informed", "consent", "form", ")", "\n", "Primary", "ITP", "according", "to", "the", "definition", "of", "Rodeghiero", "et", "al", ".", "(", "52", ")", "and", "a", "platelet", "count", "of", "<", "30x109", "/", "l", "\n", "Age", "range", ":", "18", "-", "45", "years", "\n", "Previously", "treated", "patients", ",", "with", "failure", "or", "intolerance", "to", "first", "-", "line", "therapy", ",", "or", "relapse", "after", "first", "-", "line", "therapy", ",", "i.e", ".", "corticosteroids", ",", "intravenous", "immunoglobulin", "(", "IVIG", ")", ",", "or", "anti", "-", "D", "immunoglobulins", "\n" ]	[ "Scope", "Drug", "Measurement", "Temporal", "Observation", "Procedure", "Reference_point", "Condition", "Value", "Qualifier", "Person" ]
Primary ITP, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l, Age, 18 - 45 years, Previously treated, failure, intolerance, first - line therapy, relapse, after first - line therapy, corticosteroids, intravenous immunoglobulin, IVIG, anti - D immunoglobulins	NCT02760251_inc_task2	Sentence: Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Qualifier", "O", "B-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O" ]	Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins	[ "Informed", "consent", "as", "documented", "by", "signature", "(", "see", "informed", "consent", "form", ")", "\n", "Primary", "ITP", "according", "to", "the", "definition", "of", "Rodeghiero", "et", "al", ".", "(", "52", ")", "and", "a", "platelet", "count", "of", "<", "30x109", "/", "l", "\n", "Age", "range", ":", "18", "-", "45", "years", "\n", "Previously", "treated", "patients", ",", "with", "failure", "or", "intolerance", "to", "first", "-", "line", "therapy", ",", "or", "relapse", "after", "first", "-", "line", "therapy", ",", "i.e", ".", "corticosteroids", ",", "intravenous", "immunoglobulin", "(", "IVIG", ")", ",", "or", "anti", "-", "D", "immunoglobulins", "\n" ]	[ "Scope", "Drug", "Measurement", "Temporal", "Observation", "Procedure", "Reference_point", "Condition", "Value", "Qualifier", "Person" ]
Hoehe is an umlsterm, Verletzungen is an umlsterm, Beckens is an umlsterm, unteren Extremitaeten is an umlsterm, Schultergelenkluxation is an umlsterm, Verletzung is an umlsterm, Axilla is an umlsterm, Literatur is an umlsterm, Pathophysiologie is an umlsterm, Diagnostik is an umlsterm, Verletzung is an umlsterm, Weichteilverletzungen is an umlsterm	DerUnfallchirurg.60990801.ger.abstr_task0	Sentence: Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung .	[ "Es", "wird", "der", "Fall", "eines", "36jaehrigen", "Montagearbeiters", "beschrieben", ",", "der", "nach", "Sturz", "aus", "ca", ".", "20", "m", "Hoehe", "neben", "schweren", "Verletzungen", "des", "Abdomens", ",", "des", "Beckens", "sowie", "der", "oberen", "und", "unteren", "Extremitaeten", "eine", "beidseitige", "aufrechte", ",", "untere", "Schultergelenkluxation", "(", "Luxatio", "erecta", "humeri", ")", "erlitt", ".", "Rechtsseitig", "bestand", "eine", "infrakorakoidale", "Form", ",", "linksseitig", "eine", "infraglenoidale", ",", "II", "Grad", "offene", "Verletzung", "mit", "sichtbarem", "Humeruskopf", "in", "der", "Axilla", ".", "Anhand", "dieses", "Beispiels", "und", "der", "Literatur", "wird", "die", "Pathophysiologie", ",", "Diagnostik", "und", "Behandlungsstrategie", "dieser", "seltenen", "Verletzung", "dargestellt", "und", "diskutiert", ".", "Nach", "sofortiger", "geschlossener", "Reposition", "erfordert", "das", "Vorliegen", "von", "ausgedehnten", "Weichteilverletzungen", ",", "Begleitfrakturen", "bzw", ".", "neurovaskulaeren", "Laesionen", "die", "fruehestmoegliche", "operative", "Versorgung", "." ]	[ "umlsterm" ]
Hoehe is an umlsterm, Verletzungen is an umlsterm, Beckens is an umlsterm, unteren Extremitaeten is an umlsterm, Schultergelenkluxation is an umlsterm, Verletzung is an umlsterm, Axilla is an umlsterm, Literatur is an umlsterm, Pathophysiologie is an umlsterm, Diagnostik is an umlsterm, Verletzung is an umlsterm, Weichteilverletzungen is an umlsterm	DerUnfallchirurg.60990801.ger.abstr_task1	Sentence: Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung . Instructions: please typing these entity words according to sentence: Hoehe, Verletzungen, Beckens, unteren Extremitaeten, Schultergelenkluxation, Verletzung, Axilla, Literatur, Pathophysiologie, Diagnostik, Verletzung, Weichteilverletzungen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung .	[ "Es", "wird", "der", "Fall", "eines", "36jaehrigen", "Montagearbeiters", "beschrieben", ",", "der", "nach", "Sturz", "aus", "ca", ".", "20", "m", "Hoehe", "neben", "schweren", "Verletzungen", "des", "Abdomens", ",", "des", "Beckens", "sowie", "der", "oberen", "und", "unteren", "Extremitaeten", "eine", "beidseitige", "aufrechte", ",", "untere", "Schultergelenkluxation", "(", "Luxatio", "erecta", "humeri", ")", "erlitt", ".", "Rechtsseitig", "bestand", "eine", "infrakorakoidale", "Form", ",", "linksseitig", "eine", "infraglenoidale", ",", "II", "Grad", "offene", "Verletzung", "mit", "sichtbarem", "Humeruskopf", "in", "der", "Axilla", ".", "Anhand", "dieses", "Beispiels", "und", "der", "Literatur", "wird", "die", "Pathophysiologie", ",", "Diagnostik", "und", "Behandlungsstrategie", "dieser", "seltenen", "Verletzung", "dargestellt", "und", "diskutiert", ".", "Nach", "sofortiger", "geschlossener", "Reposition", "erfordert", "das", "Vorliegen", "von", "ausgedehnten", "Weichteilverletzungen", ",", "Begleitfrakturen", "bzw", ".", "neurovaskulaeren", "Laesionen", "die", "fruehestmoegliche", "operative", "Versorgung", "." ]	[ "umlsterm" ]
Hoehe, Verletzungen, Beckens, unteren Extremitaeten, Schultergelenkluxation, Verletzung, Axilla, Literatur, Pathophysiologie, Diagnostik, Verletzung, Weichteilverletzungen	DerUnfallchirurg.60990801.ger.abstr_task2	Sentence: Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung .	[ "Es", "wird", "der", "Fall", "eines", "36jaehrigen", "Montagearbeiters", "beschrieben", ",", "der", "nach", "Sturz", "aus", "ca", ".", "20", "m", "Hoehe", "neben", "schweren", "Verletzungen", "des", "Abdomens", ",", "des", "Beckens", "sowie", "der", "oberen", "und", "unteren", "Extremitaeten", "eine", "beidseitige", "aufrechte", ",", "untere", "Schultergelenkluxation", "(", "Luxatio", "erecta", "humeri", ")", "erlitt", ".", "Rechtsseitig", "bestand", "eine", "infrakorakoidale", "Form", ",", "linksseitig", "eine", "infraglenoidale", ",", "II", "Grad", "offene", "Verletzung", "mit", "sichtbarem", "Humeruskopf", "in", "der", "Axilla", ".", "Anhand", "dieses", "Beispiels", "und", "der", "Literatur", "wird", "die", "Pathophysiologie", ",", "Diagnostik", "und", "Behandlungsstrategie", "dieser", "seltenen", "Verletzung", "dargestellt", "und", "diskutiert", ".", "Nach", "sofortiger", "geschlossener", "Reposition", "erfordert", "das", "Vorliegen", "von", "ausgedehnten", "Weichteilverletzungen", ",", "Begleitfrakturen", "bzw", ".", "neurovaskulaeren", "Laesionen", "die", "fruehestmoegliche", "operative", "Versorgung", "." ]	[ "umlsterm" ]
Cyclosporin is an umlsterm, Herztransplantation is an umlsterm, Behandlung is an umlsterm, Nierenfunktion is an umlsterm, Herzempfaengern is an umlsterm, Methoden is an umlsterm, herztransplantierte is an umlsterm, Patienten is an umlsterm, Maenner is an umlsterm, Frauen is an umlsterm, Immunsuppression is an umlsterm, Azathioprin is an umlsterm, Steroide is an umlsterm, Kreatinin is an umlsterm, Kardiomyopathie is an umlsterm, Patienten is an umlsterm, Kardiomyopathie is an umlsterm, Patientenalter is an umlsterm, Azathioprin is an umlsterm, Kreatinin is an umlsterm, Harnsaeure is an umlsterm, Patienten is an umlsterm	ZfuerHerzThoraxGefaesschirurgie.9013s032.ger.abstr_task0	Sentence: Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF .	[ "Cyclosporin", "(", "CSA", ")", "Nephrotoxizitaet", "ist", "ein", "haeufiges", "Problem", "nach", "Herztransplantation", ".", "Wir", "untersuchten", "den", "Effekt", "einer", "CSA", "-", "Dosisreduktion", "in", "Verbindung", "mit", "einer", "Mycophenolat", "Mofetil", "(", "MMF", ")", "Behandlung", "auf", "die", "Nierenfunktion", "von", "Herzempfaengern", "mit", "CSA", "-", "Nephrotoxizitaet", "(", "Serum", "-", "Kreatinin", ">", "2mg", "/", "dl", ")", ".", "Methoden", ":", "14", "herztransplantierte", "Patienten", "(", "12", "Maenner", ",", "2", "Frauen", ";", "111", "bis", "1813", "Tage", "nach", "HTX", ")", "mit", "CSA", "-", "basierter", "Immunsuppression", "(", "plus", "Azathioprin", "und", "/", "oder", "Steroide", ")", "und", "einem", "Serum", "Kreatinin", ">", "2mg", "/", "dl", "wurden", "mit", "einer", "Tagesdosis", "von", "2000", "mg", "MMF", "behandelt", ".", "Eine", "dilatative", "Kardiomyopathie", "war", "bei", "10", "Patienten", "die", "Grunderkrankung", ",", "eine", "ischaemische", "Kardiomyopathie", "bei", "4", ".", "Das", "mittlere", "Patientenalter", "betrug", "57", "Jahre", "(", "44", "-", "69", "Jahre", ")", ".", "Azathioprin", "wurde", "abgesetzt", "und", "CSA", "langsam", "reduziert", ".", "Kreatinin", "-", "Clearance", ",", "Serum", "Kreatinin", ",", "Harnstoff", "-", "N", "und", "Harnsaeure", "wurden", "kontrolliert", ".", "Cyclosporin", "-", "Spiegel", "wurden", "gemessen", "und", "die", "Dosis", "auf", "Zielspiegel", "von", "70", "-", "120µg", "/", "l", "eingestellt", ".", "12", "Patienten", "hatten", "Endomyokardbiopsien", "2", ",", "nur", "noch", "echokardiographische", "Kontrollen", ".", "Ergebnisse", ":", "Zwei", "Abstossungen", "Grad", "1B", "nach", "ISHLT", "wurden", "beobachtet", "innerhalb", "von", "einem", "Jahr", "nach", "Wechsel", "zu", "MMF", "." ]	[ "umlsterm" ]
Cyclosporin is an umlsterm, Herztransplantation is an umlsterm, Behandlung is an umlsterm, Nierenfunktion is an umlsterm, Herzempfaengern is an umlsterm, Methoden is an umlsterm, herztransplantierte is an umlsterm, Patienten is an umlsterm, Maenner is an umlsterm, Frauen is an umlsterm, Immunsuppression is an umlsterm, Azathioprin is an umlsterm, Steroide is an umlsterm, Kreatinin is an umlsterm, Kardiomyopathie is an umlsterm, Patienten is an umlsterm, Kardiomyopathie is an umlsterm, Patientenalter is an umlsterm, Azathioprin is an umlsterm, Kreatinin is an umlsterm, Harnsaeure is an umlsterm, Patienten is an umlsterm	ZfuerHerzThoraxGefaesschirurgie.9013s032.ger.abstr_task1	Sentence: Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF . Instructions: please typing these entity words according to sentence: Cyclosporin, Herztransplantation, Behandlung, Nierenfunktion, Herzempfaengern, Methoden, herztransplantierte, Patienten, Maenner, Frauen, Immunsuppression, Azathioprin, Steroide, Kreatinin, Kardiomyopathie, Patienten, Kardiomyopathie, Patientenalter, Azathioprin, Kreatinin, Harnsaeure, Patienten Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF .	[ "Cyclosporin", "(", "CSA", ")", "Nephrotoxizitaet", "ist", "ein", "haeufiges", "Problem", "nach", "Herztransplantation", ".", "Wir", "untersuchten", "den", "Effekt", "einer", "CSA", "-", "Dosisreduktion", "in", "Verbindung", "mit", "einer", "Mycophenolat", "Mofetil", "(", "MMF", ")", "Behandlung", "auf", "die", "Nierenfunktion", "von", "Herzempfaengern", "mit", "CSA", "-", "Nephrotoxizitaet", "(", "Serum", "-", "Kreatinin", ">", "2mg", "/", "dl", ")", ".", "Methoden", ":", "14", "herztransplantierte", "Patienten", "(", "12", "Maenner", ",", "2", "Frauen", ";", "111", "bis", "1813", "Tage", "nach", "HTX", ")", "mit", "CSA", "-", "basierter", "Immunsuppression", "(", "plus", "Azathioprin", "und", "/", "oder", "Steroide", ")", "und", "einem", "Serum", "Kreatinin", ">", "2mg", "/", "dl", "wurden", "mit", "einer", "Tagesdosis", "von", "2000", "mg", "MMF", "behandelt", ".", "Eine", "dilatative", "Kardiomyopathie", "war", "bei", "10", "Patienten", "die", "Grunderkrankung", ",", "eine", "ischaemische", "Kardiomyopathie", "bei", "4", ".", "Das", "mittlere", "Patientenalter", "betrug", "57", "Jahre", "(", "44", "-", "69", "Jahre", ")", ".", "Azathioprin", "wurde", "abgesetzt", "und", "CSA", "langsam", "reduziert", ".", "Kreatinin", "-", "Clearance", ",", "Serum", "Kreatinin", ",", "Harnstoff", "-", "N", "und", "Harnsaeure", "wurden", "kontrolliert", ".", "Cyclosporin", "-", "Spiegel", "wurden", "gemessen", "und", "die", "Dosis", "auf", "Zielspiegel", "von", "70", "-", "120µg", "/", "l", "eingestellt", ".", "12", "Patienten", "hatten", "Endomyokardbiopsien", "2", ",", "nur", "noch", "echokardiographische", "Kontrollen", ".", "Ergebnisse", ":", "Zwei", "Abstossungen", "Grad", "1B", "nach", "ISHLT", "wurden", "beobachtet", "innerhalb", "von", "einem", "Jahr", "nach", "Wechsel", "zu", "MMF", "." ]	[ "umlsterm" ]
Cyclosporin, Herztransplantation, Behandlung, Nierenfunktion, Herzempfaengern, Methoden, herztransplantierte, Patienten, Maenner, Frauen, Immunsuppression, Azathioprin, Steroide, Kreatinin, Kardiomyopathie, Patienten, Kardiomyopathie, Patientenalter, Azathioprin, Kreatinin, Harnsaeure, Patienten	ZfuerHerzThoraxGefaesschirurgie.9013s032.ger.abstr_task2	Sentence: Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF .	[ "Cyclosporin", "(", "CSA", ")", "Nephrotoxizitaet", "ist", "ein", "haeufiges", "Problem", "nach", "Herztransplantation", ".", "Wir", "untersuchten", "den", "Effekt", "einer", "CSA", "-", "Dosisreduktion", "in", "Verbindung", "mit", "einer", "Mycophenolat", "Mofetil", "(", "MMF", ")", "Behandlung", "auf", "die", "Nierenfunktion", "von", "Herzempfaengern", "mit", "CSA", "-", "Nephrotoxizitaet", "(", "Serum", "-", "Kreatinin", ">", "2mg", "/", "dl", ")", ".", "Methoden", ":", "14", "herztransplantierte", "Patienten", "(", "12", "Maenner", ",", "2", "Frauen", ";", "111", "bis", "1813", "Tage", "nach", "HTX", ")", "mit", "CSA", "-", "basierter", "Immunsuppression", "(", "plus", "Azathioprin", "und", "/", "oder", "Steroide", ")", "und", "einem", "Serum", "Kreatinin", ">", "2mg", "/", "dl", "wurden", "mit", "einer", "Tagesdosis", "von", "2000", "mg", "MMF", "behandelt", ".", "Eine", "dilatative", "Kardiomyopathie", "war", "bei", "10", "Patienten", "die", "Grunderkrankung", ",", "eine", "ischaemische", "Kardiomyopathie", "bei", "4", ".", "Das", "mittlere", "Patientenalter", "betrug", "57", "Jahre", "(", "44", "-", "69", "Jahre", ")", ".", "Azathioprin", "wurde", "abgesetzt", "und", "CSA", "langsam", "reduziert", ".", "Kreatinin", "-", "Clearance", ",", "Serum", "Kreatinin", ",", "Harnstoff", "-", "N", "und", "Harnsaeure", "wurden", "kontrolliert", ".", "Cyclosporin", "-", "Spiegel", "wurden", "gemessen", "und", "die", "Dosis", "auf", "Zielspiegel", "von", "70", "-", "120µg", "/", "l", "eingestellt", ".", "12", "Patienten", "hatten", "Endomyokardbiopsien", "2", ",", "nur", "noch", "echokardiographische", "Kontrollen", ".", "Ergebnisse", ":", "Zwei", "Abstossungen", "Grad", "1B", "nach", "ISHLT", "wurden", "beobachtet", "innerhalb", "von", "einem", "Jahr", "nach", "Wechsel", "zu", "MMF", "." ]	[ "umlsterm" ]
Abgeschlagenheit is an umlsterm, Ermuedung is an umlsterm, Patienten is an umlsterm, Sklerose is an umlsterm, Belastbarkeit is an umlsterm, Patienten is an umlsterm, Ruhepausen is an umlsterm, Entzuendungsmediatoren is an umlsterm, Medikamente is an umlsterm, Amantadin is an umlsterm, Therapieansaetze is an umlsterm, Aminopyridine is an umlsterm, 4-Aminopyridin is an umlsterm, epileptische Anfaelle is an umlsterm	DerNervenarzt.90700566.ger.abstr_task0	Sentence: " Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]	" Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten .	[ "\"", "Fatigue", "\"", "(", "Erschoepfung", "Abgeschlagenheit", ",", "Ermuedung", ")", ",", "ist", "ein", "haeufiges", "Symptom", "bei", "Patienten", "mit", "multipler", "Sklerose", ".", "Die", "uebermaessige", "Erschoepfung", "und", "verminderte", "Belastbarkeit", "fuehrt", "bei", "vielen", "Patienten", "zu", "Schwierigkeiten", ",", "einen", "normalen", "Tagesablauf", "zu", "bewaeltigen", ".", "Durch", "Ruhepausen", "kann", "die", "Fatigue", "nur", "zum", "Teil", "kompensiert", "werden", ".", "Die", "pathophysiologischen", "Mechanismen", "der", "Fatigue", "sind", "bisher", "nicht", "geklaert", ".", "Als", "Ursache", "kommen", "neben", "der", "direkten", "Schaedigung", "strategisch", "wichtiger", "neuroanatomischer", "Regionen", "auch", "generalisierte", "Effekte", "von", "Entzuendungsmediatoren", "in", "Betracht", ".", "Fuer", "einige", "Medikamente", "wie", "z.", "B.", "Amantadin", "konnte", "ein", "positiver", "Einfluss", "auf", "die", "Fatigue", "gezeigt", "werden", ".", "Als", "neue", "Therapieansaetze", "werden", "in", "der", "Zwischenzeit", "Aminopyridine", "(", "4-Aminopyridin", "und", "3,4-Diaminopyridin", ")", "eingesetzt", ".", "Neben", "einer", "Verbesserung", "der", "Nervenleitfaehigkeit", "haben", "diese", "beiden", "Substanzen", "wahrscheinlich", "einen", "zentral", "stimulierenden", "Effekt", ".", "Bei", "Ueberdosierung", "koennen", "deswegen", "epileptische", "Anfaelle", "und", "Verwirrtheitszustaende", "auftreten", "." ]	[ "umlsterm" ]
Abgeschlagenheit is an umlsterm, Ermuedung is an umlsterm, Patienten is an umlsterm, Sklerose is an umlsterm, Belastbarkeit is an umlsterm, Patienten is an umlsterm, Ruhepausen is an umlsterm, Entzuendungsmediatoren is an umlsterm, Medikamente is an umlsterm, Amantadin is an umlsterm, Therapieansaetze is an umlsterm, Aminopyridine is an umlsterm, 4-Aminopyridin is an umlsterm, epileptische Anfaelle is an umlsterm	DerNervenarzt.90700566.ger.abstr_task1	Sentence: " Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten . Instructions: please typing these entity words according to sentence: Abgeschlagenheit, Ermuedung, Patienten, Sklerose, Belastbarkeit, Patienten, Ruhepausen, Entzuendungsmediatoren, Medikamente, Amantadin, Therapieansaetze, Aminopyridine, 4-Aminopyridin, epileptische Anfaelle Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]	" Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten .	[ "\"", "Fatigue", "\"", "(", "Erschoepfung", "Abgeschlagenheit", ",", "Ermuedung", ")", ",", "ist", "ein", "haeufiges", "Symptom", "bei", "Patienten", "mit", "multipler", "Sklerose", ".", "Die", "uebermaessige", "Erschoepfung", "und", "verminderte", "Belastbarkeit", "fuehrt", "bei", "vielen", "Patienten", "zu", "Schwierigkeiten", ",", "einen", "normalen", "Tagesablauf", "zu", "bewaeltigen", ".", "Durch", "Ruhepausen", "kann", "die", "Fatigue", "nur", "zum", "Teil", "kompensiert", "werden", ".", "Die", "pathophysiologischen", "Mechanismen", "der", "Fatigue", "sind", "bisher", "nicht", "geklaert", ".", "Als", "Ursache", "kommen", "neben", "der", "direkten", "Schaedigung", "strategisch", "wichtiger", "neuroanatomischer", "Regionen", "auch", "generalisierte", "Effekte", "von", "Entzuendungsmediatoren", "in", "Betracht", ".", "Fuer", "einige", "Medikamente", "wie", "z.", "B.", "Amantadin", "konnte", "ein", "positiver", "Einfluss", "auf", "die", "Fatigue", "gezeigt", "werden", ".", "Als", "neue", "Therapieansaetze", "werden", "in", "der", "Zwischenzeit", "Aminopyridine", "(", "4-Aminopyridin", "und", "3,4-Diaminopyridin", ")", "eingesetzt", ".", "Neben", "einer", "Verbesserung", "der", "Nervenleitfaehigkeit", "haben", "diese", "beiden", "Substanzen", "wahrscheinlich", "einen", "zentral", "stimulierenden", "Effekt", ".", "Bei", "Ueberdosierung", "koennen", "deswegen", "epileptische", "Anfaelle", "und", "Verwirrtheitszustaende", "auftreten", "." ]	[ "umlsterm" ]
Abgeschlagenheit, Ermuedung, Patienten, Sklerose, Belastbarkeit, Patienten, Ruhepausen, Entzuendungsmediatoren, Medikamente, Amantadin, Therapieansaetze, Aminopyridine, 4-Aminopyridin, epileptische Anfaelle	DerNervenarzt.90700566.ger.abstr_task2	Sentence: " Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]	" Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten .	[ "\"", "Fatigue", "\"", "(", "Erschoepfung", "Abgeschlagenheit", ",", "Ermuedung", ")", ",", "ist", "ein", "haeufiges", "Symptom", "bei", "Patienten", "mit", "multipler", "Sklerose", ".", "Die", "uebermaessige", "Erschoepfung", "und", "verminderte", "Belastbarkeit", "fuehrt", "bei", "vielen", "Patienten", "zu", "Schwierigkeiten", ",", "einen", "normalen", "Tagesablauf", "zu", "bewaeltigen", ".", "Durch", "Ruhepausen", "kann", "die", "Fatigue", "nur", "zum", "Teil", "kompensiert", "werden", ".", "Die", "pathophysiologischen", "Mechanismen", "der", "Fatigue", "sind", "bisher", "nicht", "geklaert", ".", "Als", "Ursache", "kommen", "neben", "der", "direkten", "Schaedigung", "strategisch", "wichtiger", "neuroanatomischer", "Regionen", "auch", "generalisierte", "Effekte", "von", "Entzuendungsmediatoren", "in", "Betracht", ".", "Fuer", "einige", "Medikamente", "wie", "z.", "B.", "Amantadin", "konnte", "ein", "positiver", "Einfluss", "auf", "die", "Fatigue", "gezeigt", "werden", ".", "Als", "neue", "Therapieansaetze", "werden", "in", "der", "Zwischenzeit", "Aminopyridine", "(", "4-Aminopyridin", "und", "3,4-Diaminopyridin", ")", "eingesetzt", ".", "Neben", "einer", "Verbesserung", "der", "Nervenleitfaehigkeit", "haben", "diese", "beiden", "Substanzen", "wahrscheinlich", "einen", "zentral", "stimulierenden", "Effekt", ".", "Bei", "Ueberdosierung", "koennen", "deswegen", "epileptische", "Anfaelle", "und", "Verwirrtheitszustaende", "auftreten", "." ]	[ "umlsterm" ]
soybeans is a Plant, cancer is a Disease, soybean is a Plant, soybean is a Plant, soybean is a Plant, Soybean is a Plant, soybean is a Plant, soybean is a Plant, cancer is a Disease, cancers is a Disease, soybean is a Plant, cancer is a Disease	7884559_task0	Sentence: There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]	There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates.	[ "There", "is", "much", "evidence", "suggesting", "that", "compounds", "present", "in", "soybeans", "can", "prevent", "cancer", "in", "many", "different", "organ", "systems", ".", "The", "evidence", "for", "specific", "soybean", "-", "derived", "compounds", "having", "a", "suppressive", "effect", "on", "carcinogenesis", "in", "animal", "model", "systems", "is", "limited", ",", "however", ".", "There", "is", "evidence", "that", "the", "following", "isolated", "soybean", "derived", "products", "suppress", "carcinogenesis", "in", "vivo", ":", "a", "protease", "inhibitor", ",", "the", "Bowman", "-", "Birk", "inhibitor", ",", "inositol", "hexaphosphate", "(", "phytic", "acid", ")", "and", "the", "sterol", "beta", "-", "sitosterol", ".", "Other", "compounds", "that", "may", "be", "able", "to", "suppress", "carcinogenesis", "in", "animals", "are", "the", "soybean", "isoflavones", ".", "Soybean", "compounds", "reported", "to", "have", "other", "types", "of", "anticarcinogenic", "activity", "include", "soybean", "trypsin", "inhibitor", ",", "saponins", "and", "genistein", ".", "There", "is", "much", "evidence", "to", "suggest", "that", "diets", "containing", "large", "amounts", "of", "soybean", "products", "are", "associated", "with", "overall", "low", "cancer", "mortality", "rates", ",", "particularly", "for", "cancers", "of", "the", "colon", ",", "breast", "and", "prostate", ".", "It", "is", "believed", "that", "supplementation", "of", "human", "diets", "with", "certain", "soybean", "products", "shown", "to", "suppress", "carcinogenesis", "in", "animals", "could", "markedly", "reduce", "human", "cancer", "mortality", "rates", "." ]	[ "Plant", "Disease" ]
soybeans is a Plant, cancer is a Disease, soybean is a Plant, soybean is a Plant, soybean is a Plant, Soybean is a Plant, soybean is a Plant, soybean is a Plant, cancer is a Disease, cancers is a Disease, soybean is a Plant, cancer is a Disease	7884559_task1	Sentence: There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates. Instructions: please typing these entity words according to sentence: soybeans, cancer, soybean, soybean, soybean, Soybean, soybean, soybean, cancer, cancers, soybean, cancer Options: Disease, Plant	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]	There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates.	[ "There", "is", "much", "evidence", "suggesting", "that", "compounds", "present", "in", "soybeans", "can", "prevent", "cancer", "in", "many", "different", "organ", "systems", ".", "The", "evidence", "for", "specific", "soybean", "-", "derived", "compounds", "having", "a", "suppressive", "effect", "on", "carcinogenesis", "in", "animal", "model", "systems", "is", "limited", ",", "however", ".", "There", "is", "evidence", "that", "the", "following", "isolated", "soybean", "derived", "products", "suppress", "carcinogenesis", "in", "vivo", ":", "a", "protease", "inhibitor", ",", "the", "Bowman", "-", "Birk", "inhibitor", ",", "inositol", "hexaphosphate", "(", "phytic", "acid", ")", "and", "the", "sterol", "beta", "-", "sitosterol", ".", "Other", "compounds", "that", "may", "be", "able", "to", "suppress", "carcinogenesis", "in", "animals", "are", "the", "soybean", "isoflavones", ".", "Soybean", "compounds", "reported", "to", "have", "other", "types", "of", "anticarcinogenic", "activity", "include", "soybean", "trypsin", "inhibitor", ",", "saponins", "and", "genistein", ".", "There", "is", "much", "evidence", "to", "suggest", "that", "diets", "containing", "large", "amounts", "of", "soybean", "products", "are", "associated", "with", "overall", "low", "cancer", "mortality", "rates", ",", "particularly", "for", "cancers", "of", "the", "colon", ",", "breast", "and", "prostate", ".", "It", "is", "believed", "that", "supplementation", "of", "human", "diets", "with", "certain", "soybean", "products", "shown", "to", "suppress", "carcinogenesis", "in", "animals", "could", "markedly", "reduce", "human", "cancer", "mortality", "rates", "." ]	[ "Plant", "Disease" ]
soybeans, cancer, soybean, soybean, soybean, Soybean, soybean, soybean, cancer, cancers, soybean, cancer	7884559_task2	Sentence: There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]	There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates.	[ "There", "is", "much", "evidence", "suggesting", "that", "compounds", "present", "in", "soybeans", "can", "prevent", "cancer", "in", "many", "different", "organ", "systems", ".", "The", "evidence", "for", "specific", "soybean", "-", "derived", "compounds", "having", "a", "suppressive", "effect", "on", "carcinogenesis", "in", "animal", "model", "systems", "is", "limited", ",", "however", ".", "There", "is", "evidence", "that", "the", "following", "isolated", "soybean", "derived", "products", "suppress", "carcinogenesis", "in", "vivo", ":", "a", "protease", "inhibitor", ",", "the", "Bowman", "-", "Birk", "inhibitor", ",", "inositol", "hexaphosphate", "(", "phytic", "acid", ")", "and", "the", "sterol", "beta", "-", "sitosterol", ".", "Other", "compounds", "that", "may", "be", "able", "to", "suppress", "carcinogenesis", "in", "animals", "are", "the", "soybean", "isoflavones", ".", "Soybean", "compounds", "reported", "to", "have", "other", "types", "of", "anticarcinogenic", "activity", "include", "soybean", "trypsin", "inhibitor", ",", "saponins", "and", "genistein", ".", "There", "is", "much", "evidence", "to", "suggest", "that", "diets", "containing", "large", "amounts", "of", "soybean", "products", "are", "associated", "with", "overall", "low", "cancer", "mortality", "rates", ",", "particularly", "for", "cancers", "of", "the", "colon", ",", "breast", "and", "prostate", ".", "It", "is", "believed", "that", "supplementation", "of", "human", "diets", "with", "certain", "soybean", "products", "shown", "to", "suppress", "carcinogenesis", "in", "animals", "could", "markedly", "reduce", "human", "cancer", "mortality", "rates", "." ]	[ "Plant", "Disease" ]
HIV-1 parasitism is an other_name, T cells is a cell_type, nuclear factor of activated T cells is a protein_family_or_group	69245_task0	Sentence: Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, other_name	[ "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O" ]	Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.	[ "Host", "control", "of", "HIV-1", "parasitism", "in", "T", "cells", "by", "the", "nuclear", "factor", "of", "activated", "T", "cells", "." ]	[ "protein_family_or_group", "other_name", "cell_type", "virus", "protein_molecule", "other_organic_compound" ]
HIV-1 parasitism is an other_name, T cells is a cell_type, nuclear factor of activated T cells is a protein_family_or_group	69245_task1	Sentence: Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Instructions: please typing these entity words according to sentence: HIV-1 parasitism, T cells, nuclear factor of activated T cells Options: cell_type, protein_family_or_group, other_name	[ "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O" ]	Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.	[ "Host", "control", "of", "HIV-1", "parasitism", "in", "T", "cells", "by", "the", "nuclear", "factor", "of", "activated", "T", "cells", "." ]	[ "protein_family_or_group", "other_name", "cell_type", "virus", "protein_molecule", "other_organic_compound" ]
HIV-1 parasitism, T cells, nuclear factor of activated T cells	69245_task2	Sentence: Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O" ]	Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.	[ "Host", "control", "of", "HIV-1", "parasitism", "in", "T", "cells", "by", "the", "nuclear", "factor", "of", "activated", "T", "cells", "." ]	[ "protein_family_or_group", "other_name", "cell_type", "virus", "protein_molecule", "other_organic_compound" ]
Patienten is an umlsterm, Sarkoidose is an umlsterm, Autopsieberichte is an umlsterm, Zentralnervensystems is an umlsterm, Beurteilung is an umlsterm, Magnetresonanztomographie is an umlsterm, Diagnostik is an umlsterm, Patienten is an umlsterm, Sarkoidose is an umlsterm, Fazialisparese is an umlsterm, Patienten is an umlsterm, Marklagerlaesionen is an umlsterm, Kontrastmittelanreicherung is an umlsterm	DerRadiologe.90390889.ger.abstr_task0	Sentence: Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% .	[ "Klinische", "Untersuchungen", "an", "Patienten", "mit", "systemischer", "Sarkoidose", "sprechen", "in", "5", "%", ",", "Autopsieberichte", "in", "25", "%", "fuer", "eine", "Beteiligung", "des", "Zentralnervensystems", ".", "Ziel", "der", "Studie", "ist", "eine", "Beurteilung", "der", "Beitrags", "der", "Magnetresonanztomographie", "(", "MRT", ")", "in", "der", "Diagnostik", "der", "Neurosarkoidose", ".", "Die", "MR", "-", "Tomogramme", "von", "22", "Patienten", "mit", "gesicherter", "Sarkoidose", "und", "neurologischer", "Symptomatik", "wurden", "retrospektiv", "ausgewertet", ".", "Haeufigstes", "klinisches", "Symptom", "der", "Neurosarkoidose", "war", "eine", "Fazialisparese", "(", "10", "Patienten", ")", ".", "MR", "-", "tomographisch", "konnte", "eine", "Vielzahl", "verschiedener", "Befunde", "erhoben", "werden", ":", "periventrikulaere", "und", "Marklagerlaesionen", "in", "T2-gewichteten", "Bildern", "in", "46", "%", ",", "multiple", "bzw", ".", "miliare", "supratentorielle", "und", "infratentorielle", "Laesionen", "in", "36", "%", ",", "solitaere", "intraaxiale", "Raumforderungen", "in", "9", "%", ",", "solitaere", "extraaxiale", "Raumforderungen", "in", "5", "%", "und", "meningeale", "Kontrastmittelanreicherung", "(", "nodulaer", "oder", "diffus", ")", "in", "36", "%", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Sarkoidose is an umlsterm, Autopsieberichte is an umlsterm, Zentralnervensystems is an umlsterm, Beurteilung is an umlsterm, Magnetresonanztomographie is an umlsterm, Diagnostik is an umlsterm, Patienten is an umlsterm, Sarkoidose is an umlsterm, Fazialisparese is an umlsterm, Patienten is an umlsterm, Marklagerlaesionen is an umlsterm, Kontrastmittelanreicherung is an umlsterm	DerRadiologe.90390889.ger.abstr_task1	Sentence: Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% . Instructions: please typing these entity words according to sentence: Patienten, Sarkoidose, Autopsieberichte, Zentralnervensystems, Beurteilung, Magnetresonanztomographie, Diagnostik, Patienten, Sarkoidose, Fazialisparese, Patienten, Marklagerlaesionen, Kontrastmittelanreicherung Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% .	[ "Klinische", "Untersuchungen", "an", "Patienten", "mit", "systemischer", "Sarkoidose", "sprechen", "in", "5", "%", ",", "Autopsieberichte", "in", "25", "%", "fuer", "eine", "Beteiligung", "des", "Zentralnervensystems", ".", "Ziel", "der", "Studie", "ist", "eine", "Beurteilung", "der", "Beitrags", "der", "Magnetresonanztomographie", "(", "MRT", ")", "in", "der", "Diagnostik", "der", "Neurosarkoidose", ".", "Die", "MR", "-", "Tomogramme", "von", "22", "Patienten", "mit", "gesicherter", "Sarkoidose", "und", "neurologischer", "Symptomatik", "wurden", "retrospektiv", "ausgewertet", ".", "Haeufigstes", "klinisches", "Symptom", "der", "Neurosarkoidose", "war", "eine", "Fazialisparese", "(", "10", "Patienten", ")", ".", "MR", "-", "tomographisch", "konnte", "eine", "Vielzahl", "verschiedener", "Befunde", "erhoben", "werden", ":", "periventrikulaere", "und", "Marklagerlaesionen", "in", "T2-gewichteten", "Bildern", "in", "46", "%", ",", "multiple", "bzw", ".", "miliare", "supratentorielle", "und", "infratentorielle", "Laesionen", "in", "36", "%", ",", "solitaere", "intraaxiale", "Raumforderungen", "in", "9", "%", ",", "solitaere", "extraaxiale", "Raumforderungen", "in", "5", "%", "und", "meningeale", "Kontrastmittelanreicherung", "(", "nodulaer", "oder", "diffus", ")", "in", "36", "%", "." ]	[ "umlsterm" ]
Patienten, Sarkoidose, Autopsieberichte, Zentralnervensystems, Beurteilung, Magnetresonanztomographie, Diagnostik, Patienten, Sarkoidose, Fazialisparese, Patienten, Marklagerlaesionen, Kontrastmittelanreicherung	DerRadiologe.90390889.ger.abstr_task2	Sentence: Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% .	[ "Klinische", "Untersuchungen", "an", "Patienten", "mit", "systemischer", "Sarkoidose", "sprechen", "in", "5", "%", ",", "Autopsieberichte", "in", "25", "%", "fuer", "eine", "Beteiligung", "des", "Zentralnervensystems", ".", "Ziel", "der", "Studie", "ist", "eine", "Beurteilung", "der", "Beitrags", "der", "Magnetresonanztomographie", "(", "MRT", ")", "in", "der", "Diagnostik", "der", "Neurosarkoidose", ".", "Die", "MR", "-", "Tomogramme", "von", "22", "Patienten", "mit", "gesicherter", "Sarkoidose", "und", "neurologischer", "Symptomatik", "wurden", "retrospektiv", "ausgewertet", ".", "Haeufigstes", "klinisches", "Symptom", "der", "Neurosarkoidose", "war", "eine", "Fazialisparese", "(", "10", "Patienten", ")", ".", "MR", "-", "tomographisch", "konnte", "eine", "Vielzahl", "verschiedener", "Befunde", "erhoben", "werden", ":", "periventrikulaere", "und", "Marklagerlaesionen", "in", "T2-gewichteten", "Bildern", "in", "46", "%", ",", "multiple", "bzw", ".", "miliare", "supratentorielle", "und", "infratentorielle", "Laesionen", "in", "36", "%", ",", "solitaere", "intraaxiale", "Raumforderungen", "in", "9", "%", ",", "solitaere", "extraaxiale", "Raumforderungen", "in", "5", "%", "und", "meningeale", "Kontrastmittelanreicherung", "(", "nodulaer", "oder", "diffus", ")", "in", "36", "%", "." ]	[ "umlsterm" ]
celecoxib is a compound, Akt is a protein	DS.d1370_task0	Sentence: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]	Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.	[ "Anti", "-", "gastric", "cancer", "effects", "of", "celecoxib", ",", "a", "selective", "COX-2", "inhibitor", ",", "through", "inhibition", "of", "Akt", "signaling", "." ]	[ "compound", "protein" ]
celecoxib is a compound, Akt is a protein	DS.d1370_task1	Sentence: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. Instructions: please typing these entity words according to sentence: celecoxib, Akt Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]	Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.	[ "Anti", "-", "gastric", "cancer", "effects", "of", "celecoxib", ",", "a", "selective", "COX-2", "inhibitor", ",", "through", "inhibition", "of", "Akt", "signaling", "." ]	[ "compound", "protein" ]
celecoxib, Akt	DS.d1370_task2	Sentence: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]	Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.	[ "Anti", "-", "gastric", "cancer", "effects", "of", "celecoxib", ",", "a", "selective", "COX-2", "inhibitor", ",", "through", "inhibition", "of", "Akt", "signaling", "." ]	[ "compound", "protein" ]
city is an umlsterm, son is an umlsterm, Theodor is an umlsterm, head is an umlsterm, district hospital is an umlsterm, medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, dermatology is an umlsterm, period is an umlsterm, president is an umlsterm, Dermatology is an umlsterm, Association is an umlsterm, death is an umlsterm, city hospital is an umlsterm, War is an umlsterm, all is an umlsterm, medical facilities is an umlsterm, dermatology is an umlsterm, army hospital is an umlsterm, dermatology is an umlsterm, hospital is an umlsterm	DerHautarzt.70480762.eng.abstr_task0	Sentence: In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital .	[ "In", "1837", ",", "Germany", "'s", "first", "in", "-", "patient", "dermatological", "department", "named", "\"", "Heilanstalt", "fuer", "Flechtenkranke", "\"", "was", "founded", "by", "Dr", ".", "Albert", "Friedrich", "Veiel", "in", "the", "city", "of", "Cannstatt", "(", "which", "since", "1905", "is", "part", "of", "Stuttgart", ")", ".", "Later", "his", "son", ",", "Dr", ".", "Theodor", "Veiel", ",", "directed", "this", "private", "dermatological", "clinic", ",", "and", "became", "head", "of", "the", "district", "hospital", "of", "Cannstatt", "in", "1881", ".", "Although", "he", "was", "active", "in", "many", "areas", "of", "medicine", ",", "dermatology", "was", "his", "main", "interest", ".", "He", "very", "much", "influenced", "the", "development", "of", "dermatology", "during", "his", "period", "as", "president", "of", "the", "German", "Dermatology", "Association", "until", "his", "death", "in", "1923", ".", "In", "1935", ",", "the", "first", "dermatological", "city", "hospital", "was", "established", "in", "Cannstatt", "/", "Stuttgart", ".", "But", ",", "after", "World", "War", "II", ",", "all", "the", "medical", "facilities", "were", "taken", "over", "by", "the", "US", "Army", ".", "Thus", ",", "medical", "activities", "including", "dermatology", "had", "to", "be", "spread", "all", "over", "Stuttgart", ",", "until", "in", "1965", "they", "were", "returned", "to", "their", "former", "place", ".", "At", "the", "end", "of", "1998", ",", "the", "large", "abandoned", "US", "army", "hospital", "will", "home", "a", "totally", "renovated", "and", "modernized", "Stuttgart", "dermatology", "hospital", "." ]	[ "umlsterm" ]
city is an umlsterm, son is an umlsterm, Theodor is an umlsterm, head is an umlsterm, district hospital is an umlsterm, medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, dermatology is an umlsterm, period is an umlsterm, president is an umlsterm, Dermatology is an umlsterm, Association is an umlsterm, death is an umlsterm, city hospital is an umlsterm, War is an umlsterm, all is an umlsterm, medical facilities is an umlsterm, dermatology is an umlsterm, army hospital is an umlsterm, dermatology is an umlsterm, hospital is an umlsterm	DerHautarzt.70480762.eng.abstr_task1	Sentence: In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital . Instructions: please typing these entity words according to sentence: city, son, Theodor, head, district hospital, medicine, dermatology, development, dermatology, period, president, Dermatology, Association, death, city hospital, War, all, medical facilities, dermatology, army hospital, dermatology, hospital Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital .	[ "In", "1837", ",", "Germany", "'s", "first", "in", "-", "patient", "dermatological", "department", "named", "\"", "Heilanstalt", "fuer", "Flechtenkranke", "\"", "was", "founded", "by", "Dr", ".", "Albert", "Friedrich", "Veiel", "in", "the", "city", "of", "Cannstatt", "(", "which", "since", "1905", "is", "part", "of", "Stuttgart", ")", ".", "Later", "his", "son", ",", "Dr", ".", "Theodor", "Veiel", ",", "directed", "this", "private", "dermatological", "clinic", ",", "and", "became", "head", "of", "the", "district", "hospital", "of", "Cannstatt", "in", "1881", ".", "Although", "he", "was", "active", "in", "many", "areas", "of", "medicine", ",", "dermatology", "was", "his", "main", "interest", ".", "He", "very", "much", "influenced", "the", "development", "of", "dermatology", "during", "his", "period", "as", "president", "of", "the", "German", "Dermatology", "Association", "until", "his", "death", "in", "1923", ".", "In", "1935", ",", "the", "first", "dermatological", "city", "hospital", "was", "established", "in", "Cannstatt", "/", "Stuttgart", ".", "But", ",", "after", "World", "War", "II", ",", "all", "the", "medical", "facilities", "were", "taken", "over", "by", "the", "US", "Army", ".", "Thus", ",", "medical", "activities", "including", "dermatology", "had", "to", "be", "spread", "all", "over", "Stuttgart", ",", "until", "in", "1965", "they", "were", "returned", "to", "their", "former", "place", ".", "At", "the", "end", "of", "1998", ",", "the", "large", "abandoned", "US", "army", "hospital", "will", "home", "a", "totally", "renovated", "and", "modernized", "Stuttgart", "dermatology", "hospital", "." ]	[ "umlsterm" ]
city, son, Theodor, head, district hospital, medicine, dermatology, development, dermatology, period, president, Dermatology, Association, death, city hospital, War, all, medical facilities, dermatology, army hospital, dermatology, hospital	DerHautarzt.70480762.eng.abstr_task2	Sentence: In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital .	[ "In", "1837", ",", "Germany", "'s", "first", "in", "-", "patient", "dermatological", "department", "named", "\"", "Heilanstalt", "fuer", "Flechtenkranke", "\"", "was", "founded", "by", "Dr", ".", "Albert", "Friedrich", "Veiel", "in", "the", "city", "of", "Cannstatt", "(", "which", "since", "1905", "is", "part", "of", "Stuttgart", ")", ".", "Later", "his", "son", ",", "Dr", ".", "Theodor", "Veiel", ",", "directed", "this", "private", "dermatological", "clinic", ",", "and", "became", "head", "of", "the", "district", "hospital", "of", "Cannstatt", "in", "1881", ".", "Although", "he", "was", "active", "in", "many", "areas", "of", "medicine", ",", "dermatology", "was", "his", "main", "interest", ".", "He", "very", "much", "influenced", "the", "development", "of", "dermatology", "during", "his", "period", "as", "president", "of", "the", "German", "Dermatology", "Association", "until", "his", "death", "in", "1923", ".", "In", "1935", ",", "the", "first", "dermatological", "city", "hospital", "was", "established", "in", "Cannstatt", "/", "Stuttgart", ".", "But", ",", "after", "World", "War", "II", ",", "all", "the", "medical", "facilities", "were", "taken", "over", "by", "the", "US", "Army", ".", "Thus", ",", "medical", "activities", "including", "dermatology", "had", "to", "be", "spread", "all", "over", "Stuttgart", ",", "until", "in", "1965", "they", "were", "returned", "to", "their", "former", "place", ".", "At", "the", "end", "of", "1998", ",", "the", "large", "abandoned", "US", "army", "hospital", "will", "home", "a", "totally", "renovated", "and", "modernized", "Stuttgart", "dermatology", "hospital", "." ]	[ "umlsterm" ]
nicotine is an intervention, cardiovascular or lipid stress reactivity is an outcome, women is a participant	90_task0	Sentence: These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: intervention, participant, outcome	[ "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "B-participant", "O" ]	These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .	[ "These", "data", "show", "that", "acute", "nicotine", "administration", ",", "in", "the", "form", "of", "nicotine", "gum", ",", "has", "no", "effect", "on", "cardiovascular", "or", "lipid", "stress", "reactivity", "in", "women", "." ]	[ "outcome", "intervention", "participant" ]
nicotine is an intervention, cardiovascular or lipid stress reactivity is an outcome, women is a participant	90_task1	Sentence: These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women . Instructions: please typing these entity words according to sentence: nicotine, cardiovascular or lipid stress reactivity, women Options: intervention, participant, outcome	[ "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "B-participant", "O" ]	These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .	[ "These", "data", "show", "that", "acute", "nicotine", "administration", ",", "in", "the", "form", "of", "nicotine", "gum", ",", "has", "no", "effect", "on", "cardiovascular", "or", "lipid", "stress", "reactivity", "in", "women", "." ]	[ "outcome", "intervention", "participant" ]
nicotine, cardiovascular or lipid stress reactivity, women	90_task2	Sentence: These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "B-participant", "O" ]	These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .	[ "These", "data", "show", "that", "acute", "nicotine", "administration", ",", "in", "the", "form", "of", "nicotine", "gum", ",", "has", "no", "effect", "on", "cardiovascular", "or", "lipid", "stress", "reactivity", "in", "women", "." ]	[ "outcome", "intervention", "participant" ]
PSK is a Intervention_Pharmacological, CD57 ( + ) T cells is a Outcome_Physical, oral adjuvant immunochemotherapy is a Intervention_Pharmacological, protein - bound polysaccharide K ( PSK ) is a Intervention_Pharmacological, tegafur / uracil ( UFT ) is a Intervention_Pharmacological, UFT alone is a Intervention_Pharmacological, immunological parameters is a Outcome_Physical, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells is a Outcome_Physical, PSK plus 300 mg UFT ( PSK group ) is a Intervention_Pharmacological, control is a Intervention_Control, 3-year overall survival is a Outcome_Mortality, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T is a Outcome_Physical, 3-year survival is a Outcome_Mortality, PSK + UFT is a Intervention_Pharmacological	44924_task0	Sentence: PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mortality	[ "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer .	[ "PSK", "may", "suppress", "CD57", "(", "+", ")", "T", "cells", "to", "improve", "survival", "of", "advanced", "gastric", "cancer", "patients", ".", "BACKGROUND", "A", "recent", "report", "showed", "that", "oral", "adjuvant", "immunochemotherapy", "with", "protein", "-", "bound", "polysaccharide", "K", "(", "PSK", ")", "and", "tegafur", "/", "uracil", "(", "UFT", ")", "for", "stage", "II", "and", "III", "colorectal", "cancer", "improves", "overall", "survival", "compared", "with", "UFT", "alone", ".", "PSK", "has", "been", "supposed", "to", "improve", "survival", "through", "immunological", "mechanisms", "such", "as", "induction", "of", "cytokines", ",", "regulation", "of", "Th1", "/", "Th2", "balance", ",", "and", "inhibition", "of", "immunosuppressive", "molecules", ".", "METHODS", "We", "investigated", "the", "mechanisms", "by", "which", "PSK", "influences", "immunological", "parameters", "such", "as", "Th1", "cells", "(", "IFN", "-", "gamma", "-", "positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th2", "cells", "(", "IL-4-positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th1", "/", "Th2", "ratio", ",", "NKT", "cells", "(", "CD56", "(", "+", ")", "T", "cells", "and", "CD57", "(", "+", ")", "T", "cells", ")", ",", "NK", "cells", ",", "and", "CD25", "(", "+", ")", "CD4", "(", "+", ")", "T", "cells", "in", "stage", "III", "gastric", "cancer", "patients", ".", "Patients", "were", "randomly", "assigned", "to", "receive", "either", "3", "g", "PSK", "plus", "300", "mg", "UFT", "(", "PSK", "group", ")", "or", "300", "mg", "UFT", "alone", "(", "control", ")", "orally", "each", "day", "for", "at", "least", "1", "year", "following", "their", "operation", ".", "RESULTS", "Twenty", "-", "one", "registered", "patients", "with", "stage", "III", "gastric", "cancer", "were", "analyzed", ".", "The", "3-year", "overall", "survival", "was", "62.2", "%", "in", "the", "PSK", "group", "(", "n", "=", "10", ")", "and", "12.5", "%", "in", "the", "control", "group", "(", "n", "=", "11", ")", "(", "P", "=", "0.038", ")", ".", "Before", "operation", ",", "there", "were", "no", "significant", "differences", "in", "the", "proportions", "of", "Th1", "cells", ",", "Th2", "cells", ",", "Th1", "/", "Th2", "ratio", ",", "CD56", "(", "+", ")", "T", "cells", ",", "CD57", "(", "+", ")", "T", "cells", ",", "NK", "cells", ",", "and", "CD4", "(", "+", ")", "CD25", "(", "+", ")", "T", "cells", "between", "PSK", "and", "control", "groups", ".", "However", ",", "after", "operation", ",", "CD57", "(", "+", ")", "T", "cells", "decreased", "significantly", "in", "the", "PSK", "group", "compared", "to", "the", "control", "(", "P", "=", "0.0486", ")", ".", "When", "all", "patients", "were", "analyzed", ",", "patients", "with", "increased", "proportion", "(", ">", "18", "%", ")", "of", "CD57", "(", "+", ")", "T", "cells", "showed", "worse", "survival", "than", "those", "with", "lower", "(", "<", "or", "=", "18", "%", ")", "CD57", "(", "+", ")", "T", "cells", "(", "3-year", "survival", ",", "25.0", "and", "45.7", "%", ",", "respectively", ";", "P", "=", "0.046", ")", ",", "consistent", "with", "our", "previous", "report", "that", "high", "CD57", "(", "+", ")", "is", "an", "indicator", "of", "poor", "prognosis", "in", "patients", "with", "advanced", "gastric", "cancer", ".", "However", ",", "in", "the", "group", "treated", "with", "PSK", "+", "UFT", ",", "3-year", "survival", "of", "CD57-high", "patients", "was", "as", "great", "as", "that", "of", "CD57-low", "patients", "(", "66.7", "and", "51.4", "%", ",", "respectively", ";", "P", "=", "0.67", ")", ".", "CONCLUSION", "The", "present", "findings", "suggest", "that", "PSK", "improves", "overall", "survival", "of", "stage", "III", "gastric", "cancer", "patients", "partly", "by", "inhibiting", "CD57", "(", "+", ")", "T", "cells", ",", "a", "proven", "poor", "prognostic", "factor", "in", "advanced", "gastric", "cancer", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Mortality", "Intervention_Control" ]
PSK is a Intervention_Pharmacological, CD57 ( + ) T cells is a Outcome_Physical, oral adjuvant immunochemotherapy is a Intervention_Pharmacological, protein - bound polysaccharide K ( PSK ) is a Intervention_Pharmacological, tegafur / uracil ( UFT ) is a Intervention_Pharmacological, UFT alone is a Intervention_Pharmacological, immunological parameters is a Outcome_Physical, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells is a Outcome_Physical, PSK plus 300 mg UFT ( PSK group ) is a Intervention_Pharmacological, control is a Intervention_Control, 3-year overall survival is a Outcome_Mortality, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T is a Outcome_Physical, 3-year survival is a Outcome_Mortality, PSK + UFT is a Intervention_Pharmacological	44924_task1	Sentence: PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer . Instructions: please typing these entity words according to sentence: PSK, CD57 ( + ) T cells, oral adjuvant immunochemotherapy, protein - bound polysaccharide K ( PSK ), tegafur / uracil ( UFT ), UFT alone, immunological parameters, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells, PSK plus 300 mg UFT ( PSK group ), control, 3-year overall survival, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T, 3-year survival, PSK + UFT Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mortality	[ "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", 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"I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer .	[ "PSK", "may", "suppress", "CD57", "(", "+", ")", "T", "cells", "to", "improve", "survival", "of", "advanced", "gastric", "cancer", "patients", ".", "BACKGROUND", "A", "recent", "report", "showed", "that", "oral", "adjuvant", "immunochemotherapy", "with", "protein", "-", "bound", "polysaccharide", "K", "(", "PSK", ")", "and", "tegafur", "/", "uracil", "(", "UFT", ")", "for", "stage", "II", "and", "III", "colorectal", "cancer", "improves", "overall", "survival", "compared", "with", "UFT", "alone", ".", "PSK", "has", "been", "supposed", "to", "improve", "survival", "through", "immunological", "mechanisms", "such", "as", "induction", "of", "cytokines", ",", "regulation", "of", "Th1", "/", "Th2", "balance", ",", "and", "inhibition", "of", "immunosuppressive", "molecules", ".", "METHODS", "We", "investigated", "the", "mechanisms", "by", "which", "PSK", "influences", "immunological", "parameters", "such", "as", "Th1", "cells", "(", "IFN", "-", "gamma", "-", "positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th2", "cells", "(", "IL-4-positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th1", "/", "Th2", "ratio", ",", "NKT", "cells", "(", "CD56", "(", "+", ")", "T", "cells", "and", "CD57", "(", "+", ")", "T", "cells", ")", ",", "NK", "cells", ",", "and", "CD25", "(", "+", ")", "CD4", "(", "+", ")", "T", "cells", "in", "stage", "III", "gastric", "cancer", "patients", ".", "Patients", "were", "randomly", "assigned", "to", "receive", "either", "3", "g", "PSK", "plus", "300", "mg", "UFT", "(", "PSK", "group", ")", "or", "300", "mg", "UFT", "alone", "(", "control", ")", "orally", "each", "day", "for", "at", "least", "1", "year", "following", "their", "operation", ".", "RESULTS", "Twenty", "-", "one", "registered", "patients", "with", "stage", "III", "gastric", "cancer", "were", "analyzed", ".", "The", "3-year", "overall", "survival", "was", "62.2", "%", "in", "the", "PSK", "group", "(", "n", "=", "10", ")", "and", "12.5", "%", "in", "the", "control", "group", "(", "n", "=", "11", ")", "(", "P", "=", "0.038", ")", ".", "Before", "operation", ",", "there", "were", "no", "significant", "differences", "in", "the", "proportions", "of", "Th1", "cells", ",", "Th2", "cells", ",", "Th1", "/", "Th2", "ratio", ",", "CD56", "(", "+", ")", "T", "cells", ",", "CD57", "(", "+", ")", "T", "cells", ",", "NK", "cells", ",", "and", "CD4", "(", "+", ")", "CD25", "(", "+", ")", "T", "cells", "between", "PSK", "and", "control", "groups", ".", "However", ",", "after", "operation", ",", "CD57", "(", "+", ")", "T", "cells", "decreased", "significantly", "in", "the", "PSK", "group", "compared", "to", "the", "control", "(", "P", "=", "0.0486", ")", ".", "When", "all", "patients", "were", "analyzed", ",", "patients", "with", "increased", "proportion", "(", ">", "18", "%", ")", "of", "CD57", "(", "+", ")", "T", "cells", "showed", "worse", "survival", "than", "those", "with", "lower", "(", "<", "or", "=", "18", "%", ")", "CD57", "(", "+", ")", "T", "cells", "(", "3-year", "survival", ",", "25.0", "and", "45.7", "%", ",", "respectively", ";", "P", "=", "0.046", ")", ",", "consistent", "with", "our", "previous", "report", "that", "high", "CD57", "(", "+", ")", "is", "an", "indicator", "of", "poor", "prognosis", "in", "patients", "with", "advanced", "gastric", "cancer", ".", "However", ",", "in", "the", "group", "treated", "with", "PSK", "+", "UFT", ",", "3-year", "survival", "of", "CD57-high", "patients", "was", "as", "great", "as", "that", "of", "CD57-low", "patients", "(", "66.7", "and", "51.4", "%", ",", "respectively", ";", "P", "=", "0.67", ")", ".", "CONCLUSION", "The", "present", "findings", "suggest", "that", "PSK", "improves", "overall", "survival", "of", "stage", "III", "gastric", "cancer", "patients", "partly", "by", "inhibiting", "CD57", "(", "+", ")", "T", "cells", ",", "a", "proven", "poor", "prognostic", "factor", "in", "advanced", "gastric", "cancer", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Mortality", "Intervention_Control" ]
PSK, CD57 ( + ) T cells, oral adjuvant immunochemotherapy, protein - bound polysaccharide K ( PSK ), tegafur / uracil ( UFT ), UFT alone, immunological parameters, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells, PSK plus 300 mg UFT ( PSK group ), control, 3-year overall survival, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T, 3-year survival, PSK + UFT	44924_task2	Sentence: PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer . 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer .	[ "PSK", "may", "suppress", "CD57", "(", "+", ")", "T", "cells", "to", "improve", "survival", "of", "advanced", "gastric", "cancer", "patients", ".", "BACKGROUND", "A", "recent", "report", "showed", "that", "oral", "adjuvant", "immunochemotherapy", "with", "protein", "-", "bound", "polysaccharide", "K", "(", "PSK", ")", "and", "tegafur", "/", "uracil", "(", "UFT", ")", "for", "stage", "II", "and", "III", "colorectal", "cancer", "improves", "overall", "survival", "compared", "with", "UFT", "alone", ".", "PSK", "has", "been", "supposed", "to", "improve", "survival", "through", "immunological", "mechanisms", "such", "as", "induction", "of", "cytokines", ",", "regulation", "of", "Th1", "/", "Th2", "balance", ",", "and", "inhibition", "of", "immunosuppressive", "molecules", ".", "METHODS", "We", "investigated", "the", "mechanisms", "by", "which", "PSK", "influences", "immunological", "parameters", "such", "as", "Th1", "cells", "(", "IFN", "-", "gamma", "-", "positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th2", "cells", "(", "IL-4-positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th1", "/", "Th2", "ratio", ",", "NKT", "cells", "(", "CD56", "(", "+", ")", "T", "cells", "and", "CD57", "(", "+", ")", "T", "cells", ")", ",", "NK", "cells", ",", "and", "CD25", "(", "+", ")", "CD4", "(", "+", ")", "T", "cells", "in", "stage", "III", "gastric", "cancer", "patients", ".", "Patients", "were", "randomly", "assigned", "to", "receive", "either", "3", "g", "PSK", "plus", "300", "mg", "UFT", "(", "PSK", "group", ")", "or", "300", "mg", "UFT", "alone", "(", "control", ")", "orally", "each", "day", "for", "at", "least", "1", "year", "following", "their", "operation", ".", "RESULTS", "Twenty", "-", "one", "registered", "patients", "with", "stage", "III", "gastric", "cancer", "were", "analyzed", ".", "The", "3-year", "overall", "survival", "was", "62.2", "%", "in", "the", "PSK", "group", "(", "n", "=", "10", ")", "and", "12.5", "%", "in", "the", "control", "group", "(", "n", "=", "11", ")", "(", "P", "=", "0.038", ")", ".", "Before", "operation", ",", "there", "were", "no", "significant", "differences", "in", "the", "proportions", "of", "Th1", "cells", ",", "Th2", "cells", ",", "Th1", "/", "Th2", "ratio", ",", "CD56", "(", "+", ")", "T", "cells", ",", "CD57", "(", "+", ")", "T", "cells", ",", "NK", "cells", ",", "and", "CD4", "(", "+", ")", "CD25", "(", "+", ")", "T", "cells", "between", "PSK", "and", "control", "groups", ".", "However", ",", "after", "operation", ",", "CD57", "(", "+", ")", "T", "cells", "decreased", "significantly", "in", "the", "PSK", "group", "compared", "to", "the", "control", "(", "P", "=", "0.0486", ")", ".", "When", "all", "patients", "were", "analyzed", ",", "patients", "with", "increased", "proportion", "(", ">", "18", "%", ")", "of", "CD57", "(", "+", ")", "T", "cells", "showed", "worse", "survival", "than", "those", "with", "lower", "(", "<", "or", "=", "18", "%", ")", "CD57", "(", "+", ")", "T", "cells", "(", "3-year", "survival", ",", "25.0", "and", "45.7", "%", ",", "respectively", ";", "P", "=", "0.046", ")", ",", "consistent", "with", "our", "previous", "report", "that", "high", "CD57", "(", "+", ")", "is", "an", "indicator", "of", "poor", "prognosis", "in", "patients", "with", "advanced", "gastric", "cancer", ".", "However", ",", "in", "the", "group", "treated", "with", "PSK", "+", "UFT", ",", "3-year", "survival", "of", "CD57-high", "patients", "was", "as", "great", "as", "that", "of", "CD57-low", "patients", "(", "66.7", "and", "51.4", "%", ",", "respectively", ";", "P", "=", "0.67", ")", ".", "CONCLUSION", "The", "present", "findings", "suggest", "that", "PSK", "improves", "overall", "survival", "of", "stage", "III", "gastric", "cancer", "patients", "partly", "by", "inhibiting", "CD57", "(", "+", ")", "T", "cells", ",", "a", "proven", "poor", "prognostic", "factor", "in", "advanced", "gastric", "cancer", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Mortality", "Intervention_Control" ]
treatment is an umlsterm, patients is an umlsterm, burn injuries is an umlsterm, hands is an umlsterm, patients is an umlsterm, June is an umlsterm, patients is an umlsterm, patients is an umlsterm, Patients is an umlsterm, ABSI is an umlsterm, mortality is an umlsterm, costs is an umlsterm, DM is an umlsterm, costs is an umlsterm, costs is an umlsterm, DM is an umlsterm, costs is an umlsterm, treatment is an umlsterm, DM is an umlsterm, costs is an umlsterm, DM is an umlsterm, laboratory is an umlsterm, DM is an umlsterm, blood bank is an umlsterm, DM is an umlsterm, costs is an umlsterm, analysis is an umlsterm, costs is an umlsterm, therapy is an umlsterm, analysis is an umlsterm, individuality is an umlsterm, patients is an umlsterm	DerUnfallchirurg.60990875.eng.abstr_task0	Sentence: The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients .	[ "The", "treatment", "of", "patients", "with", "severe", "burn", "injuries", "is", "expensive", "and", "belongs", "in", "the", "hands", "of", "specialized", "burn", "centres", ".", "In", "our", "burn", "centre", "257", "patients", "were", "treated", "from", "1991", "to", "June", "1995", "(", "between", "50", "and", "60", "patients", "per", "year", "except", "for", "1993", "with", "77", "patients", ")", ".", "Patients", "were", "evaluated", "according", "to", "the", "ABSI", "score", "(", "mean", "7", ")", "and", "had", "mortality", "of", "around", "15", "%", ".", "The", "costs", "range", "between", "3.7", "and", "4.8", "million", "DM", "per", "year", ",", "the", "profit", "lies", "in", "the", "same", "range", ".", "The", "costs", "are", "divided", "into", "staff", "costs", "(", "1.4", "-", "1.8", "million", "DM", "per", "year", ")", ",", "costs", "for", "medical", "treatment", "(", "1.5", "-", "1.9", "million", "DM", "per", "year", ")", "and", "costs", "for", "internal", "services", "(", "600", "000", "-", "900", "000", "DM", "per", "year", ")", "such", "as", "laboratory", "examinations", "(", "247", "000", "-", "386", "000", "DM", "per", "year", ")", "and", "blood", "bank", "(", "100", "000", "-", "215", "000", "DM", "per", "year", ")", ",", "the", "main", "factors", "in", "this", "category", ".", "The", "different", "fields", "of", "costs", "and", "profit", "are", "compared", "in", "this", "analysis", ".", "Possible", "ways", "of", "reducing", "costs", "are", "pointed", "out", ",", "and", "the", "question", "of", "effectiveness", "of", "therapy", "is", "discussed", ".", "Conclusions", "from", "this", "analysis", "are", "limited", "by", "the", "individuality", "of", "each", "case", "with", "different", "clinical", "courses", ",", "the", "great", "number", "of", "influencing", "factors", "and", "the", "comparably", "small", "numbers", "of", "patients", "." ]	[ "umlsterm" ]
treatment is an umlsterm, patients is an umlsterm, burn injuries is an umlsterm, hands is an umlsterm, patients is an umlsterm, June is an umlsterm, patients is an umlsterm, patients is an umlsterm, Patients is an umlsterm, ABSI is an umlsterm, mortality is an umlsterm, costs is an umlsterm, DM is an umlsterm, costs is an umlsterm, costs is an umlsterm, DM is an umlsterm, costs is an umlsterm, treatment is an umlsterm, DM is an umlsterm, costs is an umlsterm, DM is an umlsterm, laboratory is an umlsterm, DM is an umlsterm, blood bank is an umlsterm, DM is an umlsterm, costs is an umlsterm, analysis is an umlsterm, costs is an umlsterm, therapy is an umlsterm, analysis is an umlsterm, individuality is an umlsterm, patients is an umlsterm	DerUnfallchirurg.60990875.eng.abstr_task1	Sentence: The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients . Instructions: please typing these entity words according to sentence: treatment, patients, burn injuries, hands, patients, June, patients, patients, Patients, ABSI, mortality, costs, DM, costs, costs, DM, costs, treatment, DM, costs, DM, laboratory, DM, blood bank, DM, costs, analysis, costs, therapy, analysis, individuality, patients Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients .	[ "The", "treatment", "of", "patients", "with", "severe", "burn", "injuries", "is", "expensive", "and", "belongs", "in", "the", "hands", "of", "specialized", "burn", "centres", ".", "In", "our", "burn", "centre", "257", "patients", "were", "treated", "from", "1991", "to", "June", "1995", "(", "between", "50", "and", "60", "patients", "per", "year", "except", "for", "1993", "with", "77", "patients", ")", ".", "Patients", "were", "evaluated", "according", "to", "the", "ABSI", "score", "(", "mean", "7", ")", "and", "had", "mortality", "of", "around", "15", "%", ".", "The", "costs", "range", "between", "3.7", "and", "4.8", "million", "DM", "per", "year", ",", "the", "profit", "lies", "in", "the", "same", "range", ".", "The", "costs", "are", "divided", "into", "staff", "costs", "(", "1.4", "-", "1.8", "million", "DM", "per", "year", ")", ",", "costs", "for", "medical", "treatment", "(", "1.5", "-", "1.9", "million", "DM", "per", "year", ")", "and", "costs", "for", "internal", "services", "(", "600", "000", "-", "900", "000", "DM", "per", "year", ")", "such", "as", "laboratory", "examinations", "(", "247", "000", "-", "386", "000", "DM", "per", "year", ")", "and", "blood", "bank", "(", "100", "000", "-", "215", "000", "DM", "per", "year", ")", ",", "the", "main", "factors", "in", "this", "category", ".", "The", "different", "fields", "of", "costs", "and", "profit", "are", "compared", "in", "this", "analysis", ".", "Possible", "ways", "of", "reducing", "costs", "are", "pointed", "out", ",", "and", "the", "question", "of", "effectiveness", "of", "therapy", "is", "discussed", ".", "Conclusions", "from", "this", "analysis", "are", "limited", "by", "the", "individuality", "of", "each", "case", "with", "different", "clinical", "courses", ",", "the", "great", "number", "of", "influencing", "factors", "and", "the", "comparably", "small", "numbers", "of", "patients", "." ]	[ "umlsterm" ]
treatment, patients, burn injuries, hands, patients, June, patients, patients, Patients, ABSI, mortality, costs, DM, costs, costs, DM, costs, treatment, DM, costs, DM, laboratory, DM, blood bank, DM, costs, analysis, costs, therapy, analysis, individuality, patients	DerUnfallchirurg.60990875.eng.abstr_task2	Sentence: The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients .	[ "The", "treatment", "of", "patients", "with", "severe", "burn", "injuries", "is", "expensive", "and", "belongs", "in", "the", "hands", "of", "specialized", "burn", "centres", ".", "In", "our", "burn", "centre", "257", "patients", "were", "treated", "from", "1991", "to", "June", "1995", "(", "between", "50", "and", "60", "patients", "per", "year", "except", "for", "1993", "with", "77", "patients", ")", ".", "Patients", "were", "evaluated", "according", "to", "the", "ABSI", "score", "(", "mean", "7", ")", "and", "had", "mortality", "of", "around", "15", "%", ".", "The", "costs", "range", "between", "3.7", "and", "4.8", "million", "DM", "per", "year", ",", "the", "profit", "lies", "in", "the", "same", "range", ".", "The", "costs", "are", "divided", "into", "staff", "costs", "(", "1.4", "-", "1.8", "million", "DM", "per", "year", ")", ",", "costs", "for", "medical", "treatment", "(", "1.5", "-", "1.9", "million", "DM", "per", "year", ")", "and", "costs", "for", "internal", "services", "(", "600", "000", "-", "900", "000", "DM", "per", "year", ")", "such", "as", "laboratory", "examinations", "(", "247", "000", "-", "386", "000", "DM", "per", "year", ")", "and", "blood", "bank", "(", "100", "000", "-", "215", "000", "DM", "per", "year", ")", ",", "the", "main", "factors", "in", "this", "category", ".", "The", "different", "fields", "of", "costs", "and", "profit", "are", "compared", "in", "this", "analysis", ".", "Possible", "ways", "of", "reducing", "costs", "are", "pointed", "out", ",", "and", "the", "question", "of", "effectiveness", "of", "therapy", "is", "discussed", ".", "Conclusions", "from", "this", "analysis", "are", "limited", "by", "the", "individuality", "of", "each", "case", "with", "different", "clinical", "courses", ",", "the", "great", "number", "of", "influencing", "factors", "and", "the", "comparably", "small", "numbers", "of", "patients", "." ]	[ "umlsterm" ]
NF - ATc is a protein_molecule, NF - ATp is a protein_molecule, cytoplasmic components is a cell_component	19289_task0	Sentence: Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_component, protein_molecule	[ "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "O" ]	Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.	[ "Cloning", "and", "characterization", "of", "NF", "-", "ATc", "and", "NF", "-", "ATp", ":", "the", "cytoplasmic", "components", "of", "NF", "-", "AT", "." ]	[ "protein_complex", "protein_family_or_group", "cell_component", "atom", "other_name", "protein_domain_or_region", "other_organic_compound", "protein_molecule", "cell_type" ]
NF - ATc is a protein_molecule, NF - ATp is a protein_molecule, cytoplasmic components is a cell_component	19289_task1	Sentence: Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Instructions: please typing these entity words according to sentence: NF - ATc, NF - ATp, cytoplasmic components Options: cell_component, protein_molecule	[ "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "O" ]	Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.	[ "Cloning", "and", "characterization", "of", "NF", "-", "ATc", "and", "NF", "-", "ATp", ":", "the", "cytoplasmic", "components", "of", "NF", "-", "AT", "." ]	[ "protein_complex", "protein_family_or_group", "cell_component", "atom", "other_name", "protein_domain_or_region", "other_organic_compound", "protein_molecule", "cell_type" ]
NF - ATc, NF - ATp, cytoplasmic components	19289_task2	Sentence: Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "O" ]	Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.	[ "Cloning", "and", "characterization", "of", "NF", "-", "ATc", "and", "NF", "-", "ATp", ":", "the", "cytoplasmic", "components", "of", "NF", "-", "AT", "." ]	[ "protein_complex", "protein_family_or_group", "cell_component", "atom", "other_name", "protein_domain_or_region", "other_organic_compound", "protein_molecule", "cell_type" ]
extraocular muscles is an umlsterm, patients is an umlsterm, thyroid - associated ophthalmopathy is an umlsterm, TAO is an umlsterm	DerOpthalmologe.70940290.eng.abstr_task0	Sentence: Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O" ]	Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) .	[ "Background", ":", "To", "determine", "the", "functional", "changes", "in", "the", "extraocular", "muscles", "in", "patients", "with", "thyroid", "-", "associated", "ophthalmopathy", "(", "TAO", ")", "." ]	[ "umlsterm" ]
extraocular muscles is an umlsterm, patients is an umlsterm, thyroid - associated ophthalmopathy is an umlsterm, TAO is an umlsterm	DerOpthalmologe.70940290.eng.abstr_task1	Sentence: Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) . Instructions: please typing these entity words according to sentence: extraocular muscles, patients, thyroid - associated ophthalmopathy, TAO Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O" ]	Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) .	[ "Background", ":", "To", "determine", "the", "functional", "changes", "in", "the", "extraocular", "muscles", "in", "patients", "with", "thyroid", "-", "associated", "ophthalmopathy", "(", "TAO", ")", "." ]	[ "umlsterm" ]
extraocular muscles, patients, thyroid - associated ophthalmopathy, TAO	DerOpthalmologe.70940290.eng.abstr_task2	Sentence: Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O" ]	Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) .	[ "Background", ":", "To", "determine", "the", "functional", "changes", "in", "the", "extraocular", "muscles", "in", "patients", "with", "thyroid", "-", "associated", "ophthalmopathy", "(", "TAO", ")", "." ]	[ "umlsterm" ]
surgical is an umlsterm, malignant is an umlsterm, choroid is an umlsterm, melanoma is an umlsterm, systolic is an umlsterm, blood pressure is an umlsterm, choroidal haemorrhages is an umlsterm, blood pressure is an umlsterm, risk of is an umlsterm, cerebral ischaemia is an umlsterm, patient is an umlsterm, malignant is an umlsterm, choroid is an umlsterm, melanoma is an umlsterm, brainstem is an umlsterm, auditory evoked potentials is an umlsterm, surgery is an umlsterm, arterial hypotension is an umlsterm, hypothermia is an umlsterm, pressure is an umlsterm, oesophageal is an umlsterm, temperature is an umlsterm, time is an umlsterm, electroencephalogram is an umlsterm, EEG is an umlsterm, time is an umlsterm, period is an umlsterm, arterial hypotension is an umlsterm, EEG is an umlsterm, knowledge is an umlsterm, literature is an umlsterm, maintenance is an umlsterm, literature is an umlsterm, acoustic neurinoma is an umlsterm, patients is an umlsterm, patient is an umlsterm, artery is an umlsterm, anatomic is an umlsterm, blood supply is an umlsterm, stenosis is an umlsterm, basilar artery is an umlsterm, cause is an umlsterm, induced hypothermia is an umlsterm, temperature is an umlsterm	DerAnaesthesist.50440785.eng.abstr_task0	Sentence: For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss .	[ "For", "surgical", "removal", "of", "a", "malignant", "choroid", "melanoma", ",", "it", "is", "necessary", "to", "reduce", "systolic", "blood", "pressure", "to", "around", "50", "-", "60", "mmHg", "in", "order", "to", "prevent", "choroidal", "haemorrhages", ".", "However", ",", "blood", "pressure", "reduction", "is", "associated", "with", "the", "risk", "of", "cerebral", "ischaemia", ".", "We", "report", "a", "patient", "with", "a", "malignant", "choroid", "melanoma", "in", "whom", "waves", "I", "and", "II", "of", "the", "brainstem", "auditory", "evoked", "potentials", "(", "BAEP", ")", "disappeared", "during", "surgery", "under", "controlled", "arterial", "hypotension", "and", "hypothermia", "(", "31.1", "°", "C", ")", ".", "The", "waves", "could", "be", "recorded", "again", "immediately", "after", "the", "mean", "arterial", "pressure", "was", "increased", "from", "48", "to", "77", "mmHg", ".", "The", "oesophageal", "temperature", "had", "dropped", "by", "0.3", "°", "C", "at", "this", "time", ".", "The", "2-channel", "electroencephalogram", "(", "EEG", ")", "showed", "no", "irregularities", "during", "this", "time", "period", ".", "A", "bilateral", ",", "reversible", ",", "apparently", "blood", "-", "pressure", "-", "dependent", "loss", "of", "waves", "I", "and", "II", "during", "arterial", "hypotension", "despite", "a", "normal", "EEG", "has", "to", "our", "knowledge", "not", "been", "previously", "described", "in", "the", "literature", ".", "The", "isolated", "loss", "of", "waves", "I", "and", "II", "with", "maintenance", "of", "waves", "III", ",", "IV", ",", "and", "V", "is", "unusual", ".", "The", "literature", "contains", "reports", "of", "acoustic", "neurinoma", "patients", "in", "whom", "only", "wave", "V", "could", "be", "recorded", ".", "This", "is", "regarded", "as", "an", "indication", "of", "continued", "impulse", "conduction", "despite", "the", "loss", "of", "waves", "I", "to", "IV", ".", "Others", "have", "observed", "a", "patient", "with", "temporary", "and", "reversible", "loss", "of", "BAEP", "wave", "I", "due", "to", "vasospasm", "of", "the", "internal", "auditory", "artery", "that", "apparently", "occurred", "during", "or", "shortly", "after", "manipulation", "of", "the", "internal", "auditory", "meatus", ".", "Assuming", "anatomic", "peculiarities", "in", "the", "blood", "supply", "to", "the", "generators", "of", "the", "BAEP", "waves", ",", "a", "stenosis", "of", "the", "basilar", "artery", "could", "be", "considered", "as", "the", "cause", "of", "the", "bilateral", "reversible", "loss", "of", "waves", "I", "and", "II", ".", "Another", "potential", "source", "could", "be", "the", "induced", "hypothermia", ",", "but", "this", "does", "not", "seem", "very", "likely", "because", "the", "patient", "'s", "temperature", "was", "0.3", "°", "C", "lower", "at", "the", "return", "of", "the", "waves", "than", "at", "their", "loss", "." ]	[ "umlsterm" ]
surgical is an umlsterm, malignant is an umlsterm, choroid is an umlsterm, melanoma is an umlsterm, systolic is an umlsterm, blood pressure is an umlsterm, choroidal haemorrhages is an umlsterm, blood pressure is an umlsterm, risk of is an umlsterm, cerebral ischaemia is an umlsterm, patient is an umlsterm, malignant is an umlsterm, choroid is an umlsterm, melanoma is an umlsterm, brainstem is an umlsterm, auditory evoked potentials is an umlsterm, surgery is an umlsterm, arterial hypotension is an umlsterm, hypothermia is an umlsterm, pressure is an umlsterm, oesophageal is an umlsterm, temperature is an umlsterm, time is an umlsterm, electroencephalogram is an umlsterm, EEG is an umlsterm, time is an umlsterm, period is an umlsterm, arterial hypotension is an umlsterm, EEG is an umlsterm, knowledge is an umlsterm, literature is an umlsterm, maintenance is an umlsterm, literature is an umlsterm, acoustic neurinoma is an umlsterm, patients is an umlsterm, patient is an umlsterm, artery is an umlsterm, anatomic is an umlsterm, blood supply is an umlsterm, stenosis is an umlsterm, basilar artery is an umlsterm, cause is an umlsterm, induced hypothermia is an umlsterm, temperature is an umlsterm	DerAnaesthesist.50440785.eng.abstr_task1	Sentence: For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss . Instructions: please typing these entity words according to sentence: surgical, malignant, choroid, melanoma, systolic, blood pressure, choroidal haemorrhages, blood pressure, risk of, cerebral ischaemia, patient, malignant, choroid, melanoma, brainstem, auditory evoked potentials, surgery, arterial hypotension, hypothermia, pressure, oesophageal, temperature, time, electroencephalogram, EEG, time, period, arterial hypotension, EEG, knowledge, literature, maintenance, literature, acoustic neurinoma, patients, patient, artery, anatomic, blood supply, stenosis, basilar artery, cause, induced hypothermia, temperature Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss .	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surgical, malignant, choroid, melanoma, systolic, blood pressure, choroidal haemorrhages, blood pressure, risk of, cerebral ischaemia, patient, malignant, choroid, melanoma, brainstem, auditory evoked potentials, surgery, arterial hypotension, hypothermia, pressure, oesophageal, temperature, time, electroencephalogram, EEG, time, period, arterial hypotension, EEG, knowledge, literature, maintenance, literature, acoustic neurinoma, patients, patient, artery, anatomic, blood supply, stenosis, basilar artery, cause, induced hypothermia, temperature	DerAnaesthesist.50440785.eng.abstr_task2	Sentence: For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss .	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TRP channel is a GENE-N, TRPA-1 is a GENE-Y, TRP channel is a GENE-N, calcium is a CHEMICAL, calcium is a CHEMICAL, PKC is a GENE-N, DAF-16 is a GENE-Y, FOXO is a GENE-Y, Human TRPA1 is a GENE-Y, worm TRPA-1 is a GENE-N, TRP channels is a GENE-N, calcium is a CHEMICAL	13115_task0	Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.	[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", ".", "\n", "Both", "poikilotherms", "and", "homeotherms", "live", "longer", "at", "lower", "body", "temperatures", ",", "highlighting", "a", "general", "role", "of", "temperature", "reduction", "in", "lifespan", "extension", ".", "However", ",", "the", "underlying", "mechanisms", "remain", "unclear", ".", "One", "prominent", "model", "is", "that", "cold", "temperatures", "reduce", "the", "rate", "of", "chemical", "reactions", ",", "thereby", "slowing", "the", "rate", "of", "aging", ".", "This", "view", "suggests", "that", "cold", "-", "dependent", "lifespan", "extension", "is", "simply", "a", "passive", "thermodynamic", "process", ".", "Here", ",", "we", "challenge", "this", "view", "in", "C.", "elegans", "by", "showing", "that", "genetic", "programs", "actively", "promote", "longevity", "at", "cold", "temperatures", ".", "We", "find", "that", "TRPA-1", ",", "a", "cold", "-", "sensitive", "TRP", "channel", ",", "detects", "temperature", "drop", "in", "the", "environment", "to", "extend", "lifespan", ".", "This", "effect", "requires", "cold", "-", "induced", ",", "TRPA-1-mediated", "calcium", "influx", "and", "a", "calcium", "-", "sensitive", "PKC", "that", "signals", "to", "the", "transcription", "factor", "DAF-16", "/", "FOXO", ".", "Human", "TRPA1", "can", "functionally", "substitute", "for", "worm", "TRPA-1", "in", "promoting", "longevity", ".", "Our", "results", "reveal", "a", "previously", "unrecognized", "function", "for", "TRP", "channels", ",", "link", "calcium", "signaling", "to", "longevity", ",", "and", ",", "importantly", ",", "demonstrate", "that", "genetic", "programs", "contribute", "to", "lifespan", "extension", "at", "cold", "temperatures", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
TRP channel is a GENE-N, TRPA-1 is a GENE-Y, TRP channel is a GENE-N, calcium is a CHEMICAL, calcium is a CHEMICAL, PKC is a GENE-N, DAF-16 is a GENE-Y, FOXO is a GENE-Y, Human TRPA1 is a GENE-Y, worm TRPA-1 is a GENE-N, TRP channels is a GENE-N, calcium is a CHEMICAL	13115_task1	Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures. Instructions: please typing these entity words according to sentence: TRP channel, TRPA-1, TRP channel, calcium, calcium, PKC, DAF-16, FOXO, Human TRPA1, worm TRPA-1, TRP channels, calcium Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.	[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", ".", "\n", "Both", "poikilotherms", "and", "homeotherms", "live", "longer", "at", "lower", "body", "temperatures", ",", "highlighting", "a", "general", "role", "of", "temperature", "reduction", "in", "lifespan", "extension", ".", "However", ",", "the", "underlying", "mechanisms", "remain", "unclear", ".", "One", "prominent", "model", "is", "that", "cold", "temperatures", "reduce", "the", "rate", "of", "chemical", "reactions", ",", "thereby", "slowing", "the", "rate", "of", "aging", ".", "This", "view", "suggests", "that", "cold", "-", "dependent", "lifespan", "extension", "is", "simply", "a", "passive", "thermodynamic", "process", ".", "Here", ",", "we", "challenge", "this", "view", "in", "C.", "elegans", "by", "showing", "that", "genetic", "programs", "actively", "promote", "longevity", "at", "cold", "temperatures", ".", "We", "find", "that", "TRPA-1", ",", "a", "cold", "-", "sensitive", "TRP", "channel", ",", "detects", "temperature", "drop", "in", "the", "environment", "to", "extend", "lifespan", ".", "This", "effect", "requires", "cold", "-", "induced", ",", "TRPA-1-mediated", "calcium", "influx", "and", "a", "calcium", "-", "sensitive", "PKC", "that", "signals", "to", "the", "transcription", "factor", "DAF-16", "/", "FOXO", ".", "Human", "TRPA1", "can", "functionally", "substitute", "for", "worm", "TRPA-1", "in", "promoting", "longevity", ".", "Our", "results", "reveal", "a", "previously", "unrecognized", "function", "for", "TRP", "channels", ",", "link", "calcium", "signaling", "to", "longevity", ",", "and", ",", "importantly", ",", "demonstrate", "that", "genetic", "programs", "contribute", "to", "lifespan", "extension", "at", "cold", "temperatures", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
TRP channel, TRPA-1, TRP channel, calcium, calcium, PKC, DAF-16, FOXO, Human TRPA1, worm TRPA-1, TRP channels, calcium	13115_task2	Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.	[ "A", "genetic", "program", "promotes", "C.", "elegans", "longevity", "at", "cold", "temperatures", "via", "a", "thermosensitive", "TRP", "channel", ".", "\n", "Both", "poikilotherms", "and", "homeotherms", "live", "longer", "at", "lower", "body", "temperatures", ",", "highlighting", "a", "general", "role", "of", "temperature", "reduction", "in", "lifespan", "extension", ".", "However", ",", "the", "underlying", "mechanisms", "remain", "unclear", ".", "One", "prominent", "model", "is", "that", "cold", "temperatures", "reduce", "the", "rate", "of", "chemical", "reactions", ",", "thereby", "slowing", "the", "rate", "of", "aging", ".", "This", "view", "suggests", "that", "cold", "-", "dependent", "lifespan", "extension", "is", "simply", "a", "passive", "thermodynamic", "process", ".", "Here", ",", "we", "challenge", "this", "view", "in", "C.", "elegans", "by", "showing", "that", "genetic", "programs", "actively", "promote", "longevity", "at", "cold", "temperatures", ".", "We", "find", "that", "TRPA-1", ",", "a", "cold", "-", "sensitive", "TRP", "channel", ",", "detects", "temperature", "drop", "in", "the", "environment", "to", "extend", "lifespan", ".", "This", "effect", "requires", "cold", "-", "induced", ",", "TRPA-1-mediated", "calcium", "influx", "and", "a", "calcium", "-", "sensitive", "PKC", "that", "signals", "to", "the", "transcription", "factor", "DAF-16", "/", "FOXO", ".", "Human", "TRPA1", "can", "functionally", "substitute", "for", "worm", "TRPA-1", "in", "promoting", "longevity", ".", "Our", "results", "reveal", "a", "previously", "unrecognized", "function", "for", "TRP", "channels", ",", "link", "calcium", "signaling", "to", "longevity", ",", "and", ",", "importantly", ",", "demonstrate", "that", "genetic", "programs", "contribute", "to", "lifespan", "extension", "at", "cold", "temperatures", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
LASIK is an umlsterm, date is an umlsterm, complication is an umlsterm, LASIK is an umlsterm, myopia is an umlsterm	DerOpthalmologe.80950494.eng.abstr_task0	Sentence: Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia .	[ "Background", ":", "Long", "-", "term", "results", "on", "LASIK", "are", "not", "available", "to", "date", ".", "We", "therefore", "evaluated", "the", "predictability", ",", "stability", "and", "complication", "rate", "after", "LASIK", "in", "moderate", "-", "to", "-", "high", "myopia", "." ]	[ "umlsterm" ]
LASIK is an umlsterm, date is an umlsterm, complication is an umlsterm, LASIK is an umlsterm, myopia is an umlsterm	DerOpthalmologe.80950494.eng.abstr_task1	Sentence: Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia . Instructions: please typing these entity words according to sentence: LASIK, date, complication, LASIK, myopia Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia .	[ "Background", ":", "Long", "-", "term", "results", "on", "LASIK", "are", "not", "available", "to", "date", ".", "We", "therefore", "evaluated", "the", "predictability", ",", "stability", "and", "complication", "rate", "after", "LASIK", "in", "moderate", "-", "to", "-", "high", "myopia", "." ]	[ "umlsterm" ]
LASIK, date, complication, LASIK, myopia	DerOpthalmologe.80950494.eng.abstr_task2	Sentence: Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia .	[ "Background", ":", "Long", "-", "term", "results", "on", "LASIK", "are", "not", "available", "to", "date", ".", "We", "therefore", "evaluated", "the", "predictability", ",", "stability", "and", "complication", "rate", "after", "LASIK", "in", "moderate", "-", "to", "-", "high", "myopia", "." ]	[ "umlsterm" ]
phosphatidylcholine synthase is a Protein, PCS is a Protein, PCS is a Protein, Pmt is a Protein, Pcs is a Protein, Pcs is a Protein, PCS is a Protein	121_task0	Sentence: Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]	Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation.	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phosphatidylcholine synthase is a Protein, PCS is a Protein, PCS is a Protein, Pmt is a Protein, Pcs is a Protein, Pcs is a Protein, PCS is a Protein	121_task1	Sentence: Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation. Instructions: please typing these entity words according to sentence: phosphatidylcholine synthase, PCS, PCS, Pmt, Pcs, Pcs, PCS Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]	Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation.	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phosphatidylcholine synthase, PCS, PCS, Pmt, Pcs, Pcs, PCS	121_task2	Sentence: Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O" ]	Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation.	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complex regional pain syndrome is a Participant_Condition, motor imagery program is a Intervention_Physical, imagined movements is a Intervention_Physical, mirror movements is a Intervention_Physical, disability is a Outcome_Physical, effect is a Outcome_Other, Twenty is a Participant_Sample-size, chronic CRPS1 initiated by wrist fracture is a Participant_Condition, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . is a Intervention_Physical	20665_task0	Sentence: Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks .	[ "Is", "successful", "rehabilitation", "of", "complex", "regional", "pain", "syndrome", "due", "to", "sustained", "attention", "to", "the", "affected", "limb", "?", "A", "randomised", "clinical", "trial", ".", "In", "complex", "regional", "pain", "syndrome", "(", "CRPS1", ")", "initiated", "by", "wrist", "fracture", ",", "a", "motor", "imagery", "program", "(", "MIP", ")", ",", "consisting", "of", "hand", "laterality", "recognition", "followed", "by", "imagined", "movements", "and", "then", "mirror", "movements", ",", "reduces", "pain", "and", "disability", ",", "but", "the", "mechanism", "of", "effect", "is", "unclear", ".", "Possibilities", "include", "sustained", "attention", "to", "the", "affected", "limb", ",", "in", "which", "case", "the", "order", "of", "MIP", "components", "would", "not", "alter", "the", "effect", ",", "and", "sequential", "activation", "of", "cortical", "motor", "networks", ",", "in", "which", "case", "it", "would", ".", "Twenty", "subjects", "with", "chronic", "CRPS1", "initiated", "by", "wrist", "fracture", "and", "who", "satisfied", "stringent", "inclusion", "criteria", ",", "were", "randomly", "allocated", "to", "one", "of", "three", "groups", ":", "hand", "laterality", "recognition", ",", "imagined", "movements", ",", "mirror", "movements", "(", "RecImMir", ",", "MIP", ")", ";", "imagined", "movements", ",", "recognition", ",", "imagined", "movements", "(", "ImRecIm", ")", ";", "recognition", ",", "mirror", "movements", ",", "recognition", "(", "RecMirRec", ")", ".", "At", "6", "and", "18", "weeks", ",", "reduced", "pain", "and", "disability", "were", "greater", "for", "the", "RecImMir", "group", "than", "for", "the", "other", "groups", "(", "P", "<", "0.05", ")", ".", "Hand", "laterality", "recognition", "imparted", "a", "consistent", "reduction", "in", "pain", "and", "disability", "across", "groups", ",", "however", ",", "this", "effect", "was", "limited", "in", "magnitude", ".", "Imagined", "movements", "imparted", "a", "further", "reduction", "in", "pain", "and", "disability", ",", "but", "only", "if", "they", "followed", "hand", "laterality", "recognition", ".", "Mirror", "movements", "also", "imparted", "a", "reduction", "in", "pain", "and", "disability", ",", "but", "only", "when", "they", "followed", "imagined", "movements", ".", "The", "effect", "of", "the", "MIP", "seems", "to", "be", "dependent", "on", "the", "order", "of", "components", ",", "which", "suggests", "that", "it", "is", "not", "due", "to", "sustained", "attention", "to", "the", "affected", "limb", ",", "but", "is", "consistent", "with", "sequential", "activation", "of", "cortical", "motor", "networks", "." ]	[ "Intervention_Physical", "Participant_Condition", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size", "Outcome_Pain" ]
complex regional pain syndrome is a Participant_Condition, motor imagery program is a Intervention_Physical, imagined movements is a Intervention_Physical, mirror movements is a Intervention_Physical, disability is a Outcome_Physical, effect is a Outcome_Other, Twenty is a Participant_Sample-size, chronic CRPS1 initiated by wrist fracture is a Participant_Condition, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . is a Intervention_Physical	20665_task1	Sentence: Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks . Instructions: please typing these entity words according to sentence: complex regional pain syndrome, motor imagery program, imagined movements, mirror movements, disability, effect, Twenty, chronic CRPS1 initiated by wrist fracture, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . Options: Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks .	[ "Is", "successful", "rehabilitation", "of", "complex", "regional", "pain", "syndrome", "due", "to", "sustained", "attention", "to", "the", "affected", "limb", "?", "A", "randomised", "clinical", "trial", ".", "In", "complex", "regional", "pain", "syndrome", "(", "CRPS1", ")", "initiated", "by", "wrist", "fracture", ",", "a", "motor", "imagery", "program", "(", "MIP", ")", ",", "consisting", "of", "hand", "laterality", "recognition", "followed", "by", "imagined", "movements", "and", "then", "mirror", "movements", ",", "reduces", "pain", "and", "disability", ",", "but", "the", "mechanism", "of", "effect", "is", "unclear", ".", "Possibilities", "include", "sustained", "attention", "to", "the", "affected", "limb", ",", "in", "which", "case", "the", "order", "of", "MIP", "components", "would", "not", "alter", "the", "effect", ",", "and", "sequential", "activation", "of", "cortical", "motor", "networks", ",", "in", "which", "case", "it", "would", ".", "Twenty", "subjects", "with", "chronic", "CRPS1", "initiated", "by", "wrist", "fracture", "and", "who", "satisfied", "stringent", "inclusion", "criteria", ",", "were", "randomly", "allocated", "to", "one", "of", "three", "groups", ":", "hand", "laterality", "recognition", ",", "imagined", "movements", ",", "mirror", "movements", "(", "RecImMir", ",", "MIP", ")", ";", "imagined", "movements", ",", "recognition", ",", "imagined", "movements", "(", "ImRecIm", ")", ";", "recognition", ",", "mirror", "movements", ",", "recognition", "(", "RecMirRec", ")", ".", "At", "6", "and", "18", "weeks", ",", "reduced", "pain", "and", "disability", "were", "greater", "for", "the", "RecImMir", "group", "than", "for", "the", "other", "groups", "(", "P", "<", "0.05", ")", ".", "Hand", "laterality", "recognition", "imparted", "a", "consistent", "reduction", "in", "pain", "and", "disability", "across", "groups", ",", "however", ",", "this", "effect", "was", "limited", "in", "magnitude", ".", "Imagined", "movements", "imparted", "a", "further", "reduction", "in", "pain", "and", "disability", ",", "but", "only", "if", "they", "followed", "hand", "laterality", "recognition", ".", "Mirror", "movements", "also", "imparted", "a", "reduction", "in", "pain", "and", "disability", ",", "but", "only", "when", "they", "followed", "imagined", "movements", ".", "The", "effect", "of", "the", "MIP", "seems", "to", "be", "dependent", "on", "the", "order", "of", "components", ",", "which", "suggests", "that", "it", "is", "not", "due", "to", "sustained", "attention", "to", "the", "affected", "limb", ",", "but", "is", "consistent", "with", "sequential", "activation", "of", "cortical", "motor", "networks", "." ]	[ "Intervention_Physical", "Participant_Condition", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size", "Outcome_Pain" ]
complex regional pain syndrome, motor imagery program, imagined movements, mirror movements, disability, effect, Twenty, chronic CRPS1 initiated by wrist fracture, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) .	20665_task2	Sentence: Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks .	[ "Is", "successful", "rehabilitation", "of", "complex", "regional", "pain", "syndrome", "due", "to", "sustained", "attention", "to", "the", "affected", "limb", "?", "A", "randomised", "clinical", "trial", ".", "In", "complex", "regional", "pain", "syndrome", "(", "CRPS1", ")", "initiated", "by", "wrist", "fracture", ",", "a", "motor", "imagery", "program", "(", "MIP", ")", ",", "consisting", "of", "hand", "laterality", "recognition", "followed", "by", "imagined", "movements", "and", "then", "mirror", "movements", ",", "reduces", "pain", "and", "disability", ",", "but", "the", "mechanism", "of", "effect", "is", "unclear", ".", "Possibilities", "include", "sustained", "attention", "to", "the", "affected", "limb", ",", "in", "which", "case", "the", "order", "of", "MIP", "components", "would", "not", "alter", "the", "effect", ",", "and", "sequential", "activation", "of", "cortical", "motor", "networks", ",", "in", "which", "case", "it", "would", ".", "Twenty", "subjects", "with", "chronic", "CRPS1", "initiated", "by", "wrist", "fracture", "and", "who", "satisfied", "stringent", "inclusion", "criteria", ",", "were", "randomly", "allocated", "to", "one", "of", "three", "groups", ":", "hand", "laterality", "recognition", ",", "imagined", "movements", ",", "mirror", "movements", "(", "RecImMir", ",", "MIP", ")", ";", "imagined", "movements", ",", "recognition", ",", "imagined", "movements", "(", "ImRecIm", ")", ";", "recognition", ",", "mirror", "movements", ",", "recognition", "(", "RecMirRec", ")", ".", "At", "6", "and", "18", "weeks", ",", "reduced", "pain", "and", "disability", "were", "greater", "for", "the", "RecImMir", "group", "than", "for", "the", "other", "groups", "(", "P", "<", "0.05", ")", ".", "Hand", "laterality", "recognition", "imparted", "a", "consistent", "reduction", "in", "pain", "and", "disability", "across", "groups", ",", "however", ",", "this", "effect", "was", "limited", "in", "magnitude", ".", "Imagined", "movements", "imparted", "a", "further", "reduction", "in", "pain", "and", "disability", ",", "but", "only", "if", "they", "followed", "hand", "laterality", "recognition", ".", "Mirror", "movements", "also", "imparted", "a", "reduction", "in", "pain", "and", "disability", ",", "but", "only", "when", "they", "followed", "imagined", "movements", ".", "The", "effect", "of", "the", "MIP", "seems", "to", "be", "dependent", "on", "the", "order", "of", "components", ",", "which", "suggests", "that", "it", "is", "not", "due", "to", "sustained", "attention", "to", "the", "affected", "limb", ",", "but", "is", "consistent", "with", "sequential", "activation", "of", "cortical", "motor", "networks", "." ]	[ "Intervention_Physical", "Participant_Condition", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size", "Outcome_Pain" ]
human phosphodiesterase is a GENE-N, cAMP is a CHEMICAL, cGMP is a CHEMICAL, PDE10A is a GENE-Y	10373451_task0	Sentence: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O" ]	Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).	[ "Cloning", "and", "characterization", "of", "a", "novel", "human", "phosphodiesterase", "that", "hydrolyzes", "both", "cAMP", "and", "cGMP", "(", "PDE10A", ")", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
human phosphodiesterase is a GENE-N, cAMP is a CHEMICAL, cGMP is a CHEMICAL, PDE10A is a GENE-Y	10373451_task1	Sentence: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). Instructions: please typing these entity words according to sentence: human phosphodiesterase, cAMP, cGMP, PDE10A Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O" ]	Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).	[ "Cloning", "and", "characterization", "of", "a", "novel", "human", "phosphodiesterase", "that", "hydrolyzes", "both", "cAMP", "and", "cGMP", "(", "PDE10A", ")", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
human phosphodiesterase, cAMP, cGMP, PDE10A	10373451_task2	Sentence: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O" ]	Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).	[ "Cloning", "and", "characterization", "of", "a", "novel", "human", "phosphodiesterase", "that", "hydrolyzes", "both", "cAMP", "and", "cGMP", "(", "PDE10A", ")", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose is a CHEMICAL, TNF - α is a GENE-Y	22532499_task0	Sentence: Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O" ]	Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes.	[ "Effect", "of", "water", "extracts", "from", "edible", "myrtaceae", "plants", "on", "uptake", "of", "2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose", "in", "TNF", "-", "α", "-", "treated", "FL83B", "mouse", "hepatocytes", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose is a CHEMICAL, TNF - α is a GENE-Y	22532499_task1	Sentence: Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Instructions: please typing these entity words according to sentence: 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose, TNF - α Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O" ]	Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes.	[ "Effect", "of", "water", "extracts", "from", "edible", "myrtaceae", "plants", "on", "uptake", "of", "2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose", "in", "TNF", "-", "α", "-", "treated", "FL83B", "mouse", "hepatocytes", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose, TNF - α	22532499_task2	Sentence: Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O" ]	Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes.	[ "Effect", "of", "water", "extracts", "from", "edible", "myrtaceae", "plants", "on", "uptake", "of", "2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose", "in", "TNF", "-", "α", "-", "treated", "FL83B", "mouse", "hepatocytes", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
psychotherapy is an umlsterm, forms is an umlsterm, treatment is an umlsterm, psychotherapy is an umlsterm, Treatment outcome is an umlsterm, sick leave is an umlsterm, medication is an umlsterm, care is an umlsterm, outpatient is an umlsterm, treatment is an umlsterm, treatment selection is an umlsterm	Psychotherapeut.90440083.eng.abstr_task0	Sentence: Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change .	[ "Short", "-", "term", "and", "long", "-", "term", "psychodynamic", "psychotherapy", "were", "the", "most", "frequent", "forms", "of", "treatment", "in", "the", "participating", "sample", "of", "therapists", ".", "Psychoanalytic", "psychotherapy", "made", "32", "%", "of", "the", "total", "of", "psychotherapeutic", "interventions", ".", "Treatment", "outcome", "shows", "substantial", "reduction", "in", "sick", "leave", ",", "psychotropic", "medication", "and", "patient", "'s", "attending", "for", "medical", "care", ".", "The", "results", "are", "discussed", "in", "terms", "of", "the", "availability", "of", "outpatient", "psychotherapeutic", "treatment", ",", "in", "terms", "of", "differential", "treatment", "selection", "and", "in", "terms", "of", "the", "validity", "of", "\"", "events", "-", "parameters", "\"", "in", "order", "to", "evaluate", "psychotherapeutic", "change", "." ]	[ "umlsterm" ]
psychotherapy is an umlsterm, forms is an umlsterm, treatment is an umlsterm, psychotherapy is an umlsterm, Treatment outcome is an umlsterm, sick leave is an umlsterm, medication is an umlsterm, care is an umlsterm, outpatient is an umlsterm, treatment is an umlsterm, treatment selection is an umlsterm	Psychotherapeut.90440083.eng.abstr_task1	Sentence: Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change . Instructions: please typing these entity words according to sentence: psychotherapy, forms, treatment, psychotherapy, Treatment outcome, sick leave, medication, care, outpatient, treatment, treatment selection Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change .	[ "Short", "-", "term", "and", "long", "-", "term", "psychodynamic", "psychotherapy", "were", "the", "most", "frequent", "forms", "of", "treatment", "in", "the", "participating", "sample", "of", "therapists", ".", "Psychoanalytic", "psychotherapy", "made", "32", "%", "of", "the", "total", "of", "psychotherapeutic", "interventions", ".", "Treatment", "outcome", "shows", "substantial", "reduction", "in", "sick", "leave", ",", "psychotropic", "medication", "and", "patient", "'s", "attending", "for", "medical", "care", ".", "The", "results", "are", "discussed", "in", "terms", "of", "the", "availability", "of", "outpatient", "psychotherapeutic", "treatment", ",", "in", "terms", "of", "differential", "treatment", "selection", "and", "in", "terms", "of", "the", "validity", "of", "\"", "events", "-", "parameters", "\"", "in", "order", "to", "evaluate", "psychotherapeutic", "change", "." ]	[ "umlsterm" ]
psychotherapy, forms, treatment, psychotherapy, Treatment outcome, sick leave, medication, care, outpatient, treatment, treatment selection	Psychotherapeut.90440083.eng.abstr_task2	Sentence: Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change .	[ "Short", "-", "term", "and", "long", "-", "term", "psychodynamic", "psychotherapy", "were", "the", "most", "frequent", "forms", "of", "treatment", "in", "the", "participating", "sample", "of", "therapists", ".", "Psychoanalytic", "psychotherapy", "made", "32", "%", "of", "the", "total", "of", "psychotherapeutic", "interventions", ".", "Treatment", "outcome", "shows", "substantial", "reduction", "in", "sick", "leave", ",", "psychotropic", "medication", "and", "patient", "'s", "attending", "for", "medical", "care", ".", "The", "results", "are", "discussed", "in", "terms", "of", "the", "availability", "of", "outpatient", "psychotherapeutic", "treatment", ",", "in", "terms", "of", "differential", "treatment", "selection", "and", "in", "terms", "of", "the", "validity", "of", "\"", "events", "-", "parameters", "\"", "in", "order", "to", "evaluate", "psychotherapeutic", "change", "." ]	[ "umlsterm" ]
transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, IgM is a PROTEINAS	443_task0	Sentence: Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica.	[ "Paciente", "mujer", "de", "13", "años", "de", "edad", ",", "sin", "antecedentes", "personales", "de", "interés", "que", "consulta", "por", "edema", "palpebral", "bilateral", "de", "tres", "días", "de", "evolución", ".", "En", "la", "anamnesis", "posterior", "dirigida", "refiere", "cefalea", "acompañante", "con", "leve", "odinofagia", ",", "sin", "fiebre", "asociada", ".", "A", "la", "exploración", "física", "se", "objetiva", "dicho", "edema", "palpebral", "bilateral", "sin", "otra", "afectación", "ocular", ",", "no", "presenta", "edemas", "en", "otras", "localizaciones", "y", "sí", "hipertrofia", "amigdalar", "2/4", "sin", "exudados", ".", "En", "los", "días", "sucesivos", "vuelve", "a", "consultar", "hasta", "en", "tres", "ocasiones", "por", "persistencia", "y", "aumento", "del", "edema", "palpebral", ",", "sin", "aparición", "de", "otra", "sintomatología", ".", "Se", "realizan", "tira", "reactiva", "de", "orina", "en", "varias", "ocasiones", "sin", "detectarse", "proteinuria", "y", "cultivo", "de", "exudado", "faríngeo", "que", "resulta", "negativo", ".", "Ante", "los", "hallazgos", "clínicos", "y", "la", "negatividad", "de", "las", "pruebas", "realizadas", "hasta", "el", "momento", ",", "se", "solicita", "estudio", "analítico", "con", "hemograma", ",", "bioquímica", "sanguínea", ",", "perfil", "hepático", "y", "sedimento", "de", "orina", "con", "resultados", "normales", "excepto", "leucocitosis", "(", "18", "460/µl", ")", "con", "predominio", "linfocítico", "(", "61,8", "%", ")", "y", "aumento", "de", "transaminasas", "(", "GOT", "139", "UI", "/", "l", ",", "GPT", "184", "UI", "/", "l", ")", ".", "A", "los", "diez", "días", "del", "inicio", "del", "cuadro", "se", "produce", "resolución", "del", "edema", "palpebral", "sin", "haberse", "evidenciado", "a", "lo", "largo", "de", "la", "evolución", "fiebre", ",", "adenopatías", "ni", "hepatoesplenomegalia", ".", "Se", "realiza", "control", "analítico", "a", "las", "tres", "semanas", "encontrando", "un", "hemograma", "sin", "alteraciones", "y", "descenso", "de", "las", "transaminasas", "hasta", "valores", "normales", "(", "GOT", "22", "UI", "/", "l", ",", "GPT", "16", "UI", "/", "l", ")", ".", "Ante", "la", "sospecha", "de", "síndrome", "mononucleósico", "se", "solicita", "serología", "de", "VEB", "y", "citomegalovirus", "(", "CMV", ")", ",", "obteniéndose", "IgM", "positiva", "frente", "a", "VEB", "lo", "que", "permite", "la", "confirmación", "diagnóstica", ".", "\n\n" ]	[ "PROTEINAS" ]
transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, IgM is a PROTEINAS	443_task1	Sentence: Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica. Instructions: please typing these entity words according to sentence: transaminasas, GOT, GPT, transaminasas, GOT, GPT, IgM Options: PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica.	[ "Paciente", "mujer", "de", "13", "años", "de", "edad", ",", "sin", "antecedentes", "personales", "de", "interés", "que", "consulta", "por", "edema", "palpebral", "bilateral", "de", "tres", "días", "de", "evolución", ".", "En", "la", "anamnesis", "posterior", "dirigida", "refiere", "cefalea", "acompañante", "con", "leve", "odinofagia", ",", "sin", "fiebre", "asociada", ".", "A", "la", "exploración", "física", "se", "objetiva", "dicho", "edema", "palpebral", "bilateral", "sin", "otra", "afectación", "ocular", ",", "no", "presenta", "edemas", "en", "otras", "localizaciones", "y", "sí", "hipertrofia", "amigdalar", "2/4", "sin", "exudados", ".", "En", "los", "días", "sucesivos", "vuelve", "a", "consultar", "hasta", "en", "tres", "ocasiones", "por", "persistencia", "y", "aumento", "del", "edema", "palpebral", ",", "sin", "aparición", "de", "otra", "sintomatología", ".", "Se", "realizan", "tira", "reactiva", "de", "orina", "en", "varias", "ocasiones", "sin", "detectarse", "proteinuria", "y", "cultivo", "de", "exudado", "faríngeo", "que", "resulta", "negativo", ".", "Ante", "los", "hallazgos", "clínicos", "y", "la", "negatividad", "de", "las", "pruebas", "realizadas", "hasta", "el", "momento", ",", "se", "solicita", "estudio", "analítico", "con", "hemograma", ",", "bioquímica", "sanguínea", ",", "perfil", "hepático", "y", "sedimento", "de", "orina", "con", "resultados", "normales", "excepto", "leucocitosis", "(", "18", "460/µl", ")", "con", "predominio", "linfocítico", "(", "61,8", "%", ")", "y", "aumento", "de", "transaminasas", "(", "GOT", "139", "UI", "/", "l", ",", "GPT", "184", "UI", "/", "l", ")", ".", "A", "los", "diez", "días", "del", "inicio", "del", "cuadro", "se", "produce", "resolución", "del", "edema", "palpebral", "sin", "haberse", "evidenciado", "a", "lo", "largo", "de", "la", "evolución", "fiebre", ",", "adenopatías", "ni", "hepatoesplenomegalia", ".", "Se", "realiza", "control", "analítico", "a", "las", "tres", "semanas", "encontrando", "un", "hemograma", "sin", "alteraciones", "y", "descenso", "de", "las", "transaminasas", "hasta", "valores", "normales", "(", "GOT", "22", "UI", "/", "l", ",", "GPT", "16", "UI", "/", "l", ")", ".", "Ante", "la", "sospecha", "de", "síndrome", "mononucleósico", "se", "solicita", "serología", "de", "VEB", "y", "citomegalovirus", "(", "CMV", ")", ",", "obteniéndose", "IgM", "positiva", "frente", "a", "VEB", "lo", "que", "permite", "la", "confirmación", "diagnóstica", ".", "\n\n" ]	[ "PROTEINAS" ]
transaminasas, GOT, GPT, transaminasas, GOT, GPT, IgM	443_task2	Sentence: Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica.	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polymerase chain reaction is an umlsterm, PCR is an umlsterm, assay is an umlsterm, dermatophytes is an umlsterm, gene is an umlsterm, rRNA is an umlsterm, fungi is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, yeasts is an umlsterm, oligonucleotides is an umlsterm, identification is an umlsterm, dermatophytes is an umlsterm, Candida albicans is an umlsterm, analysis is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, yeasts is an umlsterm, PCR is an umlsterm, fungi is an umlsterm, human is an umlsterm, DNA is an umlsterm, dermis is an umlsterm, epidermis is an umlsterm, DNA is an umlsterm, plants is an umlsterm, animals is an umlsterm, PCR is an umlsterm, assay is an umlsterm, skin is an umlsterm, nail is an umlsterm, PCR is an umlsterm, culture is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, culture is an umlsterm, Sensitivity is an umlsterm, PCR is an umlsterm, culture is an umlsterm, PCR is an umlsterm, culture is an umlsterm, dermatophytes is an umlsterm	DerHautarzt.70480175.eng.abstr_task0	Sentence: A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes .	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polymerase chain reaction is an umlsterm, PCR is an umlsterm, assay is an umlsterm, dermatophytes is an umlsterm, gene is an umlsterm, rRNA is an umlsterm, fungi is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, yeasts is an umlsterm, oligonucleotides is an umlsterm, identification is an umlsterm, dermatophytes is an umlsterm, Candida albicans is an umlsterm, analysis is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, yeasts is an umlsterm, PCR is an umlsterm, fungi is an umlsterm, human is an umlsterm, DNA is an umlsterm, dermis is an umlsterm, epidermis is an umlsterm, DNA is an umlsterm, plants is an umlsterm, animals is an umlsterm, PCR is an umlsterm, assay is an umlsterm, skin is an umlsterm, nail is an umlsterm, PCR is an umlsterm, culture is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, culture is an umlsterm, Sensitivity is an umlsterm, PCR is an umlsterm, culture is an umlsterm, PCR is an umlsterm, culture is an umlsterm, dermatophytes is an umlsterm	DerHautarzt.70480175.eng.abstr_task1	Sentence: A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes . Instructions: please typing these entity words according to sentence: polymerase chain reaction, PCR, assay, dermatophytes, gene, rRNA, fungi, PCR, dermatophytes, yeasts, oligonucleotides, identification, dermatophytes, Candida albicans, analysis, PCR, dermatophytes, yeasts, PCR, fungi, human, DNA, dermis, epidermis, DNA, plants, animals, PCR, assay, skin, nail, PCR, culture, PCR, dermatophytes, culture, Sensitivity, PCR, culture, PCR, culture, dermatophytes Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes .	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polymerase chain reaction, PCR, assay, dermatophytes, gene, rRNA, fungi, PCR, dermatophytes, yeasts, oligonucleotides, identification, dermatophytes, Candida albicans, analysis, PCR, dermatophytes, yeasts, PCR, fungi, human, DNA, dermis, epidermis, DNA, plants, animals, PCR, assay, skin, nail, PCR, culture, PCR, dermatophytes, culture, Sensitivity, PCR, culture, PCR, culture, dermatophytes	DerHautarzt.70480175.eng.abstr_task2	Sentence: A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes .	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GTP is a compound, ras is a protein, Rheb is a protein	DS.d1001_task0	Sentence: The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O" ]	The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.	[ "The", "dominant", "positive", "regulator", "of", "mTORC1", "is", "the", "GTP", "-", "charged", "form", "of", "the", "ras", "-", "like", "GTPase", "Rheb", "." ]	[ "protein", "compound" ]
GTP is a compound, ras is a protein, Rheb is a protein	DS.d1001_task1	Sentence: The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb. Instructions: please typing these entity words according to sentence: GTP, ras, Rheb Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O" ]	The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.	[ "The", "dominant", "positive", "regulator", "of", "mTORC1", "is", "the", "GTP", "-", "charged", "form", "of", "the", "ras", "-", "like", "GTPase", "Rheb", "." ]	[ "protein", "compound" ]
GTP, ras, Rheb	DS.d1001_task2	Sentence: The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O" ]	The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.	[ "The", "dominant", "positive", "regulator", "of", "mTORC1", "is", "the", "GTP", "-", "charged", "form", "of", "the", "ras", "-", "like", "GTPase", "Rheb", "." ]	[ "protein", "compound" ]
progesterone is a compound, 17beta - estradiol is a compound, gonadotropin - releasing hormone is a protein	DS.d1245_task0	Sentence: The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.	[ "The", "secretion", "of", "endorphins", ",", "progesterone", "(", "P(4", ")", ")", ",", "human", "chorionic", "gonadotropin", ",", "17beta", "-", "estradiol", ",", "and", "gonadotropin", "-", "releasing", "hormone", "by", "trophoblasts", "that", "lie", "adjacent", "to", "the", "embryoblast", "in", "the", "blastocyst", "suggests", "that", "these", "pregnancy", "-", "associated", "factors", "may", "directly", "signal", "the", "growth", "and", "development", "of", "the", "embryoblast", "." ]	[ "protein", "compound" ]
progesterone is a compound, 17beta - estradiol is a compound, gonadotropin - releasing hormone is a protein	DS.d1245_task1	Sentence: The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast. Instructions: please typing these entity words according to sentence: progesterone, 17beta - estradiol, gonadotropin - releasing hormone Options: compound, protein	[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.	[ "The", "secretion", "of", "endorphins", ",", "progesterone", "(", "P(4", ")", ")", ",", "human", "chorionic", "gonadotropin", ",", "17beta", "-", "estradiol", ",", "and", "gonadotropin", "-", "releasing", "hormone", "by", "trophoblasts", "that", "lie", "adjacent", "to", "the", "embryoblast", "in", "the", "blastocyst", "suggests", "that", "these", "pregnancy", "-", "associated", "factors", "may", "directly", "signal", "the", "growth", "and", "development", "of", "the", "embryoblast", "." ]	[ "protein", "compound" ]
progesterone, 17beta - estradiol, gonadotropin - releasing hormone	DS.d1245_task2	Sentence: The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.	[ "The", "secretion", "of", "endorphins", ",", "progesterone", "(", "P(4", ")", ")", ",", "human", "chorionic", "gonadotropin", ",", "17beta", "-", "estradiol", ",", "and", "gonadotropin", "-", "releasing", "hormone", "by", "trophoblasts", "that", "lie", "adjacent", "to", "the", "embryoblast", "in", "the", "blastocyst", "suggests", "that", "these", "pregnancy", "-", "associated", "factors", "may", "directly", "signal", "the", "growth", "and", "development", "of", "the", "embryoblast", "." ]	[ "protein", "compound" ]
Patienten is an umlsterm, Stenose is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Herzbeutel - Tamponade is an umlsterm, Blutdruckabfall is an umlsterm, Schmerzsymptomatik is an umlsterm, Herzbeuteltamponade is an umlsterm, Perikarderguss is an umlsterm, Blut is an umlsterm, Kontrollangiographie is an umlsterm, Venen - Bypass is an umlsterm, Patient is an umlsterm	ZfuerKardiologie.80870233.ger.abstr_task0	Sentence: Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden .	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Patienten is an umlsterm, Stenose is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Herzbeutel - Tamponade is an umlsterm, Blutdruckabfall is an umlsterm, Schmerzsymptomatik is an umlsterm, Herzbeuteltamponade is an umlsterm, Perikarderguss is an umlsterm, Blut is an umlsterm, Kontrollangiographie is an umlsterm, Venen - Bypass is an umlsterm, Patient is an umlsterm	ZfuerKardiologie.80870233.ger.abstr_task1	Sentence: Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden . Instructions: please typing these entity words according to sentence: Patienten, Stenose, Stenose, Stent, Stenose, Stent, Herzbeutel - Tamponade, Blutdruckabfall, Schmerzsymptomatik, Herzbeuteltamponade, Perikarderguss, Blut, Kontrollangiographie, Venen - Bypass, Patient Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden .	[ "Bei", "einem", "70jaehrigen", "Patienten", "mit", "koronarer", "Dreigefaesserkrankung", "und", "Zustand", "nach", "ACB", "-", "Operation", "1989", "zeigte", "die", "diagnostische", "Kerzkatheteruntersuchung", "eine", "filiforme", "Ostiumstenose", "des", "Lambda", "-", "Bypasses", "(", "R.", "circumflexus", "und", "R.", "marginalis", ")", "sowie", "eine", "filiforme", "Stenose", "des", "RIVA", "-", "Bypasses", "unmittelbar", "vor", "der", "peripheren", "Anastomose", ".", "Der", "ACD", "-", "Bypass", "war", "verschlossen", ".", "Waehrend", "die", "Stenose", "des", "Lambda", "-", "Bypasses", "problemlos", "mit", "gutem", "Primaerresultat", "mit", "einem", "Stent", "versorgt", "werden", "kann", ",", "kommt", "es", "beim", "Versuch", ",", "die", "filiforme", "Stenose", "des", "RIVA", "-", "ACB", "zu", "dilatieren", "bzw", ".", "einen", "Stent", "zu", "implantieren", ",", "zu", "der", "seltenen", "vital", "bedrohlichen", "Bypass", "-", "Perforation", "mit", "einer", "sich", "rasch", "entwickelnden", "Herzbeutel", "-", "Tamponade", ".", "Wegen", "sofortigem", "Blutdruckabfall", "mit", "schwerster", "Schmerzsymptomatik", "wird", "sofort", "ein", "Autoperfusionskatheter", "im", "Bereich", "der", "Perforationsstelle", "positioniert", ",", "worauf", "sich", "die", "haemodynamische", "Situation", "stabilisiert", ".", "Ein", "Abdichten", "durch", "mehrfaches", "Aufblasen", "und", "Ablassen", "des", "Perfusionsballons", "war", "nicht", "moeglich", ",", "so", "dass", "dieser", "entfaltet", "im", "Gefaess", "belassen", "wird", ".", "Dennoch", "kommt", "es", "im", "weiteren", "Verlauf", "zu", "einer", "Herzbeuteltamponade", ".", "Der", "abgekapselte", "Perikarderguss", "wird", "an", "atypischer", "Stelle", "(", "intercostal", ")", "erfolgreich", "punktiert", ".", "Ueber", "einen", "Perikard", "-", "Pigtail", "-", "Katheter", "werden", "in", "der", "naechsten", "Stunde", "ca", ".", "sieben", "Liter", "Blut", "entnommen", "und", "retransfundiert", ".", "Da", "der", "kardiologisch", "interventionelle", "Weg", "zwar", "die", "Situation", "stabilisiert", ",", "das", "Problem", "des", "Abdichtens", "der", "Perforationsstelle", "jedoch", "nicht", "loesen", "kann", ",", "faellt", "die", "Entscheidung", "zur", "Operation", ".", "Mittels", "linksthorakaler", "Thoraktomie", "werden", "saemtliche", "Blutkoagel", "ausgeraeumt", ",", "trotz", "sorgfaeltigster", "Inspektion", "kann", "jedoch", "keine", "Blutungsquelle", "ausfindig", "gemacht", "werden", ".", "Somit", "muss", "von", "einem", "Spontanverschluss", "der", "Perforationsstelle", "durch", "Thrombusbildung", "ausgegangen", "werden", ".", "Eine", "Kontrollangiographie", "eine", "Woche", "spaeter", "zeigte", "ein", "gutes", "Resultat", "sowohl", "am", "Lambda", "-", "Bypass", "als", "auch", "am", "Venen", "-", "Bypass", "auf", "den", "RIVA", "ohne", "Extravasat", "oder", "Nachweis", "der", "ehemaligen", "Perforationsstelle", ".", "Der", "Patient", "konnte", "in", "beschwerdefreiem", "Zustand", "nach", "Hause", "entlassen", "werden", "." ]	[ "umlsterm" ]
Patienten, Stenose, Stenose, Stent, Stenose, Stent, Herzbeutel - Tamponade, Blutdruckabfall, Schmerzsymptomatik, Herzbeuteltamponade, Perikarderguss, Blut, Kontrollangiographie, Venen - Bypass, Patient	ZfuerKardiologie.80870233.ger.abstr_task2	Sentence: Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden .	[ "Bei", "einem", "70jaehrigen", "Patienten", "mit", "koronarer", "Dreigefaesserkrankung", "und", "Zustand", "nach", "ACB", "-", "Operation", "1989", "zeigte", "die", "diagnostische", "Kerzkatheteruntersuchung", "eine", "filiforme", "Ostiumstenose", "des", "Lambda", "-", "Bypasses", "(", "R.", "circumflexus", "und", "R.", "marginalis", ")", "sowie", "eine", "filiforme", "Stenose", "des", "RIVA", "-", "Bypasses", "unmittelbar", "vor", "der", "peripheren", "Anastomose", ".", "Der", "ACD", "-", "Bypass", "war", "verschlossen", ".", "Waehrend", "die", "Stenose", "des", "Lambda", "-", "Bypasses", "problemlos", "mit", "gutem", "Primaerresultat", "mit", "einem", "Stent", "versorgt", "werden", "kann", ",", "kommt", "es", "beim", "Versuch", ",", "die", "filiforme", "Stenose", "des", "RIVA", "-", "ACB", "zu", "dilatieren", "bzw", ".", "einen", "Stent", "zu", "implantieren", ",", "zu", "der", "seltenen", "vital", "bedrohlichen", "Bypass", "-", "Perforation", "mit", "einer", "sich", "rasch", "entwickelnden", "Herzbeutel", "-", "Tamponade", ".", "Wegen", "sofortigem", "Blutdruckabfall", "mit", "schwerster", "Schmerzsymptomatik", "wird", "sofort", "ein", "Autoperfusionskatheter", "im", "Bereich", "der", "Perforationsstelle", "positioniert", ",", "worauf", "sich", "die", "haemodynamische", "Situation", "stabilisiert", ".", "Ein", "Abdichten", "durch", "mehrfaches", "Aufblasen", "und", "Ablassen", "des", "Perfusionsballons", "war", "nicht", "moeglich", ",", "so", "dass", "dieser", "entfaltet", "im", "Gefaess", "belassen", "wird", ".", "Dennoch", "kommt", "es", "im", "weiteren", "Verlauf", "zu", "einer", "Herzbeuteltamponade", ".", "Der", "abgekapselte", "Perikarderguss", "wird", "an", "atypischer", "Stelle", "(", "intercostal", ")", "erfolgreich", "punktiert", ".", "Ueber", "einen", "Perikard", "-", "Pigtail", "-", "Katheter", "werden", "in", "der", "naechsten", "Stunde", "ca", ".", "sieben", "Liter", "Blut", "entnommen", "und", "retransfundiert", ".", "Da", "der", "kardiologisch", "interventionelle", "Weg", "zwar", "die", "Situation", "stabilisiert", ",", "das", "Problem", "des", "Abdichtens", "der", "Perforationsstelle", "jedoch", "nicht", "loesen", "kann", ",", "faellt", "die", "Entscheidung", "zur", "Operation", ".", "Mittels", "linksthorakaler", "Thoraktomie", "werden", "saemtliche", "Blutkoagel", "ausgeraeumt", ",", "trotz", "sorgfaeltigster", "Inspektion", "kann", "jedoch", "keine", "Blutungsquelle", "ausfindig", "gemacht", "werden", ".", "Somit", "muss", "von", "einem", "Spontanverschluss", "der", "Perforationsstelle", "durch", "Thrombusbildung", "ausgegangen", "werden", ".", "Eine", "Kontrollangiographie", "eine", "Woche", "spaeter", "zeigte", "ein", "gutes", "Resultat", "sowohl", "am", "Lambda", "-", "Bypass", "als", "auch", "am", "Venen", "-", "Bypass", "auf", "den", "RIVA", "ohne", "Extravasat", "oder", "Nachweis", "der", "ehemaligen", "Perforationsstelle", ".", "Der", "Patient", "konnte", "in", "beschwerdefreiem", "Zustand", "nach", "Hause", "entlassen", "werden", "." ]	[ "umlsterm" ]
Notfallbehandlung is an umlsterm, Thoraxschmerzes is an umlsterm, Patienten is an umlsterm, Myokardinfarkt is an umlsterm, Koronarsyndrom is an umlsterm, Behandlung is an umlsterm, Akutdiagnostik is an umlsterm, Zeit is an umlsterm, Rolle is an umlsterm, Ischaemietoleranz is an umlsterm, Myokards is an umlsterm, Zeit is an umlsterm, Infarktgefaesses is an umlsterm, Infarktstunde is an umlsterm, Patienten is an umlsterm, Herzrhythmusstoerungen is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm	IntensiveMedizin.90360727.ger.abstr_task0	Sentence: Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik .	[ "Die", "praeklinische", "Notfallbehandlung", "des", "akuten", "Thoraxschmerzes", "zaehlt", "zu", "den", "haeufigsten", "Einsaetzen", "des", "Notarztes", ",", "wobei", "bei", "ca", ".", "einem", "Drittel", "der", "Patienten", "ein", "akuter", "Myokardinfarkt", "oder", "im", "weiteren", "Sinne", "ein", "akutes", "Koronarsyndrom", "vorliegt", ".", "Zur", "akuten", "Behandlung", "bedarf", "es", "einer", "klaren", "Vorstellung", "von", "der", "Pathogenese", ",", "der", "klinischen", "Symptomatik", ",", "der", "moeglichen", "Akutdiagnostik", "und", "den", "therapeutischen", "Optionen", ".", "Dabei", "spielt", "der", "Faktor", "Zeit", "die", "entscheidenden", "Rolle", "!", "Aufgrund", "der", "geringen", "Ischaemietoleranz", "des", "Myokards", "bestimmt", "die", "Zeit", "zwischen", "Symptombeginn", "und", "Wiedereroeffnung", "des", "Infarktgefaesses", "einerseits", "den", "Erfolg", "der", "Reperfusionstherapie", "und", "andererseits", "sterben", "in", "der", "ersten", "Infarktstunde", "schon", "ca", ".", "30", "%", "der", "Patienten", "vorrangig", "durch", "auftretenden", "ventrikulaere", "Herzrhythmusstoerungen", ".", "In", "der", "vorliegenden", "Uebersicht", "wird", "auf", "die", "akute", "praeklinische", "Diagnostik", "und", "moegliche", "Therapie", "ausfuehrlich", "eingegangen", ",", "mit", "dem", "Ziel", "der", "sofortigen", "Einleitung", "einer", "spezifischen", "Therapie", ",", "der", "sicheren", "Ueberwachung", "und", "des", "sicheren", "Transportes", "des", "Patienten", "in", "die", "Klinik", "." ]	[ "umlsterm" ]
Notfallbehandlung is an umlsterm, Thoraxschmerzes is an umlsterm, Patienten is an umlsterm, Myokardinfarkt is an umlsterm, Koronarsyndrom is an umlsterm, Behandlung is an umlsterm, Akutdiagnostik is an umlsterm, Zeit is an umlsterm, Rolle is an umlsterm, Ischaemietoleranz is an umlsterm, Myokards is an umlsterm, Zeit is an umlsterm, Infarktgefaesses is an umlsterm, Infarktstunde is an umlsterm, Patienten is an umlsterm, Herzrhythmusstoerungen is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm	IntensiveMedizin.90360727.ger.abstr_task1	Sentence: Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik . Instructions: please typing these entity words according to sentence: Notfallbehandlung, Thoraxschmerzes, Patienten, Myokardinfarkt, Koronarsyndrom, Behandlung, Akutdiagnostik, Zeit, Rolle, Ischaemietoleranz, Myokards, Zeit, Infarktgefaesses, Infarktstunde, Patienten, Herzrhythmusstoerungen, Diagnostik, Therapie, Therapie, Patienten Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik .	[ "Die", "praeklinische", "Notfallbehandlung", "des", "akuten", "Thoraxschmerzes", "zaehlt", "zu", "den", "haeufigsten", "Einsaetzen", "des", "Notarztes", ",", "wobei", "bei", "ca", ".", "einem", "Drittel", "der", "Patienten", "ein", "akuter", "Myokardinfarkt", "oder", "im", "weiteren", "Sinne", "ein", "akutes", "Koronarsyndrom", "vorliegt", ".", "Zur", "akuten", "Behandlung", "bedarf", "es", "einer", "klaren", "Vorstellung", "von", "der", "Pathogenese", ",", "der", "klinischen", "Symptomatik", ",", "der", "moeglichen", "Akutdiagnostik", "und", "den", "therapeutischen", "Optionen", ".", "Dabei", "spielt", "der", "Faktor", "Zeit", "die", "entscheidenden", "Rolle", "!", "Aufgrund", "der", "geringen", "Ischaemietoleranz", "des", "Myokards", "bestimmt", "die", "Zeit", "zwischen", "Symptombeginn", "und", "Wiedereroeffnung", "des", "Infarktgefaesses", "einerseits", "den", "Erfolg", "der", "Reperfusionstherapie", "und", "andererseits", "sterben", "in", "der", "ersten", "Infarktstunde", "schon", "ca", ".", "30", "%", "der", "Patienten", "vorrangig", "durch", "auftretenden", "ventrikulaere", "Herzrhythmusstoerungen", ".", "In", "der", "vorliegenden", "Uebersicht", "wird", "auf", "die", "akute", "praeklinische", "Diagnostik", "und", "moegliche", "Therapie", "ausfuehrlich", "eingegangen", ",", "mit", "dem", "Ziel", "der", "sofortigen", "Einleitung", "einer", "spezifischen", "Therapie", ",", "der", "sicheren", "Ueberwachung", "und", "des", "sicheren", "Transportes", "des", "Patienten", "in", "die", "Klinik", "." ]	[ "umlsterm" ]
Notfallbehandlung, Thoraxschmerzes, Patienten, Myokardinfarkt, Koronarsyndrom, Behandlung, Akutdiagnostik, Zeit, Rolle, Ischaemietoleranz, Myokards, Zeit, Infarktgefaesses, Infarktstunde, Patienten, Herzrhythmusstoerungen, Diagnostik, Therapie, Therapie, Patienten	IntensiveMedizin.90360727.ger.abstr_task2	Sentence: Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik .	[ "Die", "praeklinische", "Notfallbehandlung", "des", "akuten", "Thoraxschmerzes", "zaehlt", "zu", "den", "haeufigsten", "Einsaetzen", "des", "Notarztes", ",", "wobei", "bei", "ca", ".", "einem", "Drittel", "der", "Patienten", "ein", "akuter", "Myokardinfarkt", "oder", "im", "weiteren", "Sinne", "ein", "akutes", "Koronarsyndrom", "vorliegt", ".", "Zur", "akuten", "Behandlung", "bedarf", "es", "einer", "klaren", "Vorstellung", "von", "der", "Pathogenese", ",", "der", "klinischen", "Symptomatik", ",", "der", "moeglichen", "Akutdiagnostik", "und", "den", "therapeutischen", "Optionen", ".", "Dabei", "spielt", "der", "Faktor", "Zeit", "die", "entscheidenden", "Rolle", "!", "Aufgrund", "der", "geringen", "Ischaemietoleranz", "des", "Myokards", "bestimmt", "die", "Zeit", "zwischen", "Symptombeginn", "und", "Wiedereroeffnung", "des", "Infarktgefaesses", "einerseits", "den", "Erfolg", "der", "Reperfusionstherapie", "und", "andererseits", "sterben", "in", "der", "ersten", "Infarktstunde", "schon", "ca", ".", "30", "%", "der", "Patienten", "vorrangig", "durch", "auftretenden", "ventrikulaere", "Herzrhythmusstoerungen", ".", "In", "der", "vorliegenden", "Uebersicht", "wird", "auf", "die", "akute", "praeklinische", "Diagnostik", "und", "moegliche", "Therapie", "ausfuehrlich", "eingegangen", ",", "mit", "dem", "Ziel", "der", "sofortigen", "Einleitung", "einer", "spezifischen", "Therapie", ",", "der", "sicheren", "Ueberwachung", "und", "des", "sicheren", "Transportes", "des", "Patienten", "in", "die", "Klinik", "." ]	[ "umlsterm" ]

aim, prospective study, patent foramen ovale, contrast, risk factors, atherosclerosis, patients, ischemic, All, patients, neurological examination, NMR, transesophageal echocardiography, patent foramen ovale, patients, risk factors, atherosclerosis, patients, patent foramen ovale, age, hypertension, diabetes, use, oral contraceptives, atrial fibrillation, aneurysm, Multivariate analysis, risk factors, atherosclerosis, hypertension, diabetes, age, risk factors, patients, foramen ovale, patients, patent foramen ovale, use, oral contraceptives, risk factor, ischemic, Patients, ischemic, foramen ovale, age, patients, foramen ovale, frequency, hypertension, diabetes, patients, atrial fibrillation, Patients, patent foramen ovale, risk factors, atherosclerosis, use, oral contraceptives, aneurysm

IntensiveMedizin.80350607.eng.abstr_task2

Sentence: The aim of this prospective study was to assess the clinical and prognostic relevance of patent foramen ovale - in contrast to risk factors for atherosclerosis and cardioembolic sources - in 208 patients with cerebral ischemic events . All patients underwent neurological examination ( Doppler , CT , NMR ) as well as transthoracic and transesophageal echocardiography . A patent foramen ovale was found in 75 patients ( 36% ) . With regard to risk factors for atherosclerosis patients with closed resp. patent foramen ovale revealed significant differencies for age , hypertension , diabetes and use of oral contraceptives . Cardioembolic sources showed significant differencies for atrial fibrillation and atrial septal aneurysm . Multivariate analysis of risk factors for atherosclerosis and cardioembolic sources revealed hypertension and diabetes as age dependant risk factors in patients with closed foramen ovale . In patients with patent foramen ovale the use of oral contraceptives was found as an independant risk factor for cerebral ischemic event . Patients > 60 years with cerebral ischemic events had more often a closed foramen ovale . Dependant on age patients with closed foramen ovale showed a higher frequency of hypertension and diabetes . In addition these patients revealed more often atrial fibrillation . Patients with patent foramen ovale had fewer risk factors for atherosclerosis or cardioembolic sources but presented more frequent the use of oral contraceptives or atrial septal aneurysm . Instructions: please extract entity words from the input sentence

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The aim of this prospective study was to assess the clinical and prognostic relevance of patent foramen ovale - in contrast to risk factors for atherosclerosis and cardioembolic sources - in 208 patients with cerebral ischemic events . All patients underwent neurological examination ( Doppler , CT , NMR ) as well as transthoracic and transesophageal echocardiography . A patent foramen ovale was found in 75 patients ( 36% ) . With regard to risk factors for atherosclerosis patients with closed resp. patent foramen ovale revealed significant differencies for age , hypertension , diabetes and use of oral contraceptives . Cardioembolic sources showed significant differencies for atrial fibrillation and atrial septal aneurysm . Multivariate analysis of risk factors for atherosclerosis and cardioembolic sources revealed hypertension and diabetes as age dependant risk factors in patients with closed foramen ovale . In patients with patent foramen ovale the use of oral contraceptives was found as an independant risk factor for cerebral ischemic event . Patients > 60 years with cerebral ischemic events had more often a closed foramen ovale . Dependant on age patients with closed foramen ovale showed a higher frequency of hypertension and diabetes . In addition these patients revealed more often atrial fibrillation . Patients with patent foramen ovale had fewer risk factors for atherosclerosis or cardioembolic sources but presented more frequent the use of oral contraceptives or atrial septal aneurysm .

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[ "umlsterm" ]

Physiology is an umlsterm, Health is an umlsterm, Evaluation is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, critically ill is an umlsterm, patients is an umlsterm, APACHE III is an umlsterm, Europe is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, ICU is an umlsterm, value is an umlsterm, hospital mortality is an umlsterm, Method is an umlsterm, patients is an umlsterm, APACHE II is an umlsterm, values is an umlsterm, survivors is an umlsterm, Mann - Whitney U test is an umlsterm, Receiver operating characteristics is an umlsterm, ROC analysis is an umlsterm, ROC curves is an umlsterm, patients is an umlsterm, hospital is an umlsterm, APACHE II is an umlsterm, ROC curve is an umlsterm, APACHE III is an umlsterm, APACHE II is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, value is an umlsterm, ICU is an umlsterm, patients is an umlsterm, APACHE III is an umlsterm, hospital mortality is an umlsterm, APACHE II is an umlsterm, APACHE III is an umlsterm, Glasgow Coma Scale is an umlsterm

DerAnaesthesist.50440037.eng.abstr_task0

Sentence: The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements .

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DerAnaesthesist.50440037.eng.abstr_task1

Sentence: The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements . Instructions: please typing these entity words according to sentence: Physiology, Health, Evaluation, APACHE II, APACHE III, critically ill, patients, APACHE III, Europe, APACHE II, APACHE III, patients, intensive care unit, ICU, value, hospital mortality, Method, patients, APACHE II, values, survivors, Mann - Whitney U test, Receiver operating characteristics, ROC analysis, ROC curves, patients, hospital, APACHE II, ROC curve, APACHE III, APACHE II, APACHE II, APACHE III, value, ICU, patients, APACHE III, hospital mortality, APACHE II, APACHE III, Glasgow Coma Scale Options: umlsterm

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The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements .

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[ "umlsterm" ]

Physiology, Health, Evaluation, APACHE II, APACHE III, critically ill, patients, APACHE III, Europe, APACHE II, APACHE III, patients, intensive care unit, ICU, value, hospital mortality, Method, patients, APACHE II, values, survivors, Mann - Whitney U test, Receiver operating characteristics, ROC analysis, ROC curves, patients, hospital, APACHE II, ROC curve, APACHE III, APACHE II, APACHE II, APACHE III, value, ICU, patients, APACHE III, hospital mortality, APACHE II, APACHE III, Glasgow Coma Scale

DerAnaesthesist.50440037.eng.abstr_task2

Sentence: The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements . Instructions: please extract entity words from the input sentence

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The Acute Physiology and Chronic Health Evaluation model ( APACHE II , APACHE III ) is used to describe the severity of illness and predict the outcome in critically ill patients . APACHE III , introduced in 1991 , has not yet been validated in Europe . We calculated APACHE II and APACHE III scores in patients after admission to the intensive care unit ( ICU ) and compared the prognostic value on hospital mortality . Method . One hundred fifty patients with stay of over 24 h were enrolled in the study and prospectively and consecutively investigated . APACHE II and III scores were calculated as described by the authors . The mean and median values of the survivors were compared with the non-surviving group ( Mann-Whitney U test ) . Receiver operating characteristics ( ROC analysis ) and the areas under the ROC curves were plotted . Results . Of the 150 patients , 34 died during their hospital stay ( 22.7% ) . The mean and median APACHE II and III scores were significantly higher ( P 0.001 ) in the non-surviving group . The area under the ROC curve was higher for APACHE III ( 0.899 ) compared to APACHE II ( 0.847 ) . Conclusions . APACHE II and APACHE III were both found to have good prognostic value in general ICU patients . Our results suggest that the APACHE III version includes a more precise prediction of hospital mortality than APACHE II . A new aspect of APACHE III is an expanded modification of the Glasgow Coma Scale to assess neurologic derangements .

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[ "umlsterm" ]

dissection is an umlsterm, emergency situation is an umlsterm, diagnosis is an umlsterm, mortality is an umlsterm, chest pain is an umlsterm, Transesophageal echocardiography is an umlsterm, computed tomography is an umlsterm, magnetic resonance imaging is an umlsterm, aortography is an umlsterm, diagnostic is an umlsterm, dissection is an umlsterm, flap is an umlsterm, tears is an umlsterm, complications is an umlsterm, pleural effusions is an umlsterm, aortic insufficiency is an umlsterm, arteries is an umlsterm, Treatment is an umlsterm, hemodynamic is an umlsterm, systolic is an umlsterm, blood pressure is an umlsterm, stress is an umlsterm, dissections is an umlsterm, ascending aorta is an umlsterm, surgery is an umlsterm, dissections is an umlsterm, descending aorta is an umlsterm, surgical treatment is an umlsterm, hypertension is an umlsterm, dissection is an umlsterm, treatment is an umlsterm, patients is an umlsterm, dissections is an umlsterm, surgical is an umlsterm, risks is an umlsterm

IntensiveMedizin.80350593.eng.abstr_task0

Sentence: Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks .

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[ "umlsterm" ]

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IntensiveMedizin.80350593.eng.abstr_task1

Sentence: Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks . Instructions: please typing these entity words according to sentence: dissection, emergency situation, diagnosis, mortality, chest pain, Transesophageal echocardiography, computed tomography, magnetic resonance imaging, aortography, diagnostic, dissection, flap, tears, complications, pleural effusions, aortic insufficiency, arteries, Treatment, hemodynamic, systolic, blood pressure, stress, dissections, ascending aorta, surgery, dissections, descending aorta, surgical treatment, hypertension, dissection, treatment, patients, dissections, surgical, risks Options: umlsterm

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Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks .

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[ "umlsterm" ]

dissection, emergency situation, diagnosis, mortality, chest pain, Transesophageal echocardiography, computed tomography, magnetic resonance imaging, aortography, diagnostic, dissection, flap, tears, complications, pleural effusions, aortic insufficiency, arteries, Treatment, hemodynamic, systolic, blood pressure, stress, dissections, ascending aorta, surgery, dissections, descending aorta, surgical treatment, hypertension, dissection, treatment, patients, dissections, surgical, risks

IntensiveMedizin.80350593.eng.abstr_task2

Sentence: Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks . Instructions: please extract entity words from the input sentence

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Acute aortic dissection is an emergency situation , and the diagnosis must be confirmed as soon as possible because of high early mortality . Severe , persistent chest pain of sudden onset is characteristic . Transesophageal echocardiography , computed tomography , magnetic resonance imaging , and aortography have comparable diagnostic accuracy with advantages and disadvantages , which are discussed in this overview . Echocardiography in aortic dissection can detect an intimal flap , intimal tears , the true and false lumen , complications such as pericardial and pleural effusions , aortic insufficiency , and involvement of the coronary arteries . Treatment includes the hemodynamic stabilization , simultaneous reduction of the systolic blood pressure , and reduction of the pulsatile aortic flow ( shear stress ) . All acute dissections involving the ascending aorta should be treated promptly with surgery . For dissections arising in the descending aorta , surgical treatment may be delayed until the hypertension and dissection have been stabilized . Permanent medical treatment may be offered in patients with type B dissections which tend to be poor surgical risks .

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[ "umlsterm" ]

fluoride is a Intervention_Pharmacological, chlorhexidine is a Intervention_Pharmacological, microflora of dental root surfaces is a Outcome_Physical, Forty - four patients , surgically treated for advanced periodontal disease is a Participant_Condition, control group is a Intervention_Control, Mutans streptococci on root surfaces were suppressed is a Outcome_Physical, increase in the number of Actinomyces viscosus / naeslundii is a Outcome_Physical, increase in the number of decayed and filled root surfaces is a Outcome_Physical, initial root - surface lesions had hardened is a Outcome_Physical

42844_task0

Sentence: Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Control, Intervention_Pharmacological, Outcome_Physical, Participant_Condition

[ "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O" ]

Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups .

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[ "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]

fluoride is a Intervention_Pharmacological, chlorhexidine is a Intervention_Pharmacological, microflora of dental root surfaces is a Outcome_Physical, Forty - four patients , surgically treated for advanced periodontal disease is a Participant_Condition, control group is a Intervention_Control, Mutans streptococci on root surfaces were suppressed is a Outcome_Physical, increase in the number of Actinomyces viscosus / naeslundii is a Outcome_Physical, increase in the number of decayed and filled root surfaces is a Outcome_Physical, initial root - surface lesions had hardened is a Outcome_Physical

42844_task1

Sentence: Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups . Instructions: please typing these entity words according to sentence: fluoride, chlorhexidine, microflora of dental root surfaces, Forty - four patients , surgically treated for advanced periodontal disease, control group, Mutans streptococci on root surfaces were suppressed, increase in the number of Actinomyces viscosus / naeslundii, increase in the number of decayed and filled root surfaces, initial root - surface lesions had hardened Options: Intervention_Control, Intervention_Pharmacological, Outcome_Physical, Participant_Condition

[ "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O" ]

Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups .

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[ "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]

fluoride, chlorhexidine, microflora of dental root surfaces, Forty - four patients , surgically treated for advanced periodontal disease, control group, Mutans streptococci on root surfaces were suppressed, increase in the number of Actinomyces viscosus / naeslundii, increase in the number of decayed and filled root surfaces, initial root - surface lesions had hardened

42844_task2

Sentence: Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O" ]

Effects of fluoride and chlorhexidine on the microflora of dental root surfaces and progression of root-surface caries . The effects of fluoride and chlorhexidine varnishes on the microflora of dental root surfaces and on the progression of root-surface caries were studied . Forty-four patients , surgically treated for advanced periodontal disease , were distributed at random among three groups . All patients received a standardized preventive treatment . Furthermore , the dentition of the patients in the two experimental groups was treated , at three-month intervals , with chlorhexidine and fluoride varnish , respectively . Patients in the control group received no additional treatment . In the experimental groups , plaque samples were collected from selected sound and carious root surfaces at baseline and at three , six , and nine months after the onset of the study . The presence of root-surface caries was scored at baseline and after one year . In addition , the texture , depth , and color of the root-surface lesions were monitored . Mutans streptococci on root surfaces were suppressed significantly ( p less than 0.05 ) during the whole experimental period in the chlorhexidine varnish group , but not in the fluoride varnish group . A non-significant increase in the number of Actinomyces viscosus/naeslundii was noted after treatment with chlorhexidine and fluoride varnish . The increase in the number of decayed and filled root surfaces after one year was significantly lower in the experimental groups than in the control group . After treatment with chlorhexidine varnish , significantly more initial root-surface lesions had hardened than in the other groups .

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[ "Participant_Condition", "Outcome_Physical", "Intervention_Pharmacological", "Intervention_Control" ]

Weights and heights is an outcome

841_task0

Sentence: Weights and heights were measured at the tri-monthly treatment visits for a period of one year . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: outcome

[ "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Weights and heights were measured at the tri-monthly treatment visits for a period of one year .

[ "Weights", "and", "heights", "were", "measured", "at", "the", "tri", "-", "monthly", "treatment", "visits", "for", "a", "period", "of", "one", "year", "." ]

[ "outcome" ]

Weights and heights is an outcome

841_task1

Sentence: Weights and heights were measured at the tri-monthly treatment visits for a period of one year . Instructions: please typing these entity words according to sentence: Weights and heights Options: outcome

[ "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Weights and heights were measured at the tri-monthly treatment visits for a period of one year .

[ "Weights", "and", "heights", "were", "measured", "at", "the", "tri", "-", "monthly", "treatment", "visits", "for", "a", "period", "of", "one", "year", "." ]

[ "outcome" ]

Weights and heights

841_task2

Sentence: Weights and heights were measured at the tri-monthly treatment visits for a period of one year . Instructions: please extract entity words from the input sentence

[ "B-outcome", "I-outcome", "I-outcome", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Weights and heights were measured at the tri-monthly treatment visits for a period of one year .

[ "Weights", "and", "heights", "were", "measured", "at", "the", "tri", "-", "monthly", "treatment", "visits", "for", "a", "period", "of", "one", "year", "." ]

[ "outcome" ]

PKC is a protein, PMA is a compound, PKC is a protein

DS.d1322_task0

Sentence: 4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.

[ "4", ")", "PKA", "regulates", "neurotransmission", "without", "PKC", "involvement", "because", ",", "after", "PMA", "or", "CaC", "modulation", "of", "the", "PKC", "activity", ",", "coupling", "to", "the", "ACh", "release", "of", "PKA", "can", "normally", "be", "stimulated", "with", "Sp-8-BrcAMP", "or", "inhibited", "with", "H-89", "." ]

[ "compound", "protein" ]

PKC is a protein, PMA is a compound, PKC is a protein

DS.d1322_task1

Sentence: 4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89. Instructions: please typing these entity words according to sentence: PKC, PMA, PKC Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.

[ "4", ")", "PKA", "regulates", "neurotransmission", "without", "PKC", "involvement", "because", ",", "after", "PMA", "or", "CaC", "modulation", "of", "the", "PKC", "activity", ",", "coupling", "to", "the", "ACh", "release", "of", "PKA", "can", "normally", "be", "stimulated", "with", "Sp-8-BrcAMP", "or", "inhibited", "with", "H-89", "." ]

[ "compound", "protein" ]

PKC, PMA, PKC

DS.d1322_task2

Sentence: 4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

4) PKA regulates neurotransmission without PKC involvement because, after PMA or CaC modulation of the PKC activity, coupling to the ACh release of PKA can normally be stimulated with Sp-8-BrcAMP or inhibited with H-89.

[ "4", ")", "PKA", "regulates", "neurotransmission", "without", "PKC", "involvement", "because", ",", "after", "PMA", "or", "CaC", "modulation", "of", "the", "PKC", "activity", ",", "coupling", "to", "the", "ACh", "release", "of", "PKA", "can", "normally", "be", "stimulated", "with", "Sp-8-BrcAMP", "or", "inhibited", "with", "H-89", "." ]

[ "compound", "protein" ]

Primary ITP is a Condition, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l is a Scope, Age is a Person, 18 - 45 years is a Value, Previously treated is a Observation, failure is a Qualifier, intolerance is a Qualifier, first - line therapy is a Procedure, relapse is a Condition, after first - line therapy is a Temporal, corticosteroids is a Drug, intravenous immunoglobulin is a Drug, IVIG is a Drug, anti - D immunoglobulins is a Drug

NCT02760251_inc_task0

Sentence: Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Scope, Drug

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Qualifier", "O", "B-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O" ]

Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins

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[ "Scope", "Drug", "Measurement", "Temporal", "Observation", "Procedure", "Reference_point", "Condition", "Value", "Qualifier", "Person" ]

Primary ITP is a Condition, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l is a Scope, Age is a Person, 18 - 45 years is a Value, Previously treated is a Observation, failure is a Qualifier, intolerance is a Qualifier, first - line therapy is a Procedure, relapse is a Condition, after first - line therapy is a Temporal, corticosteroids is a Drug, intravenous immunoglobulin is a Drug, IVIG is a Drug, anti - D immunoglobulins is a Drug

NCT02760251_inc_task1

Sentence: Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins Instructions: please typing these entity words according to sentence: Primary ITP, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l, Age, 18 - 45 years, Previously treated, failure, intolerance, first - line therapy, relapse, after first - line therapy, corticosteroids, intravenous immunoglobulin, IVIG, anti - D immunoglobulins Options: Temporal, Condition, Qualifier, Value, Person, Observation, Procedure, Scope, Drug

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Qualifier", "O", "B-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O" ]

Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins

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[ "Scope", "Drug", "Measurement", "Temporal", "Observation", "Procedure", "Reference_point", "Condition", "Value", "Qualifier", "Person" ]

Primary ITP, definition of Rodeghiero et al . ( 52 ) and a platelet count of < 30x109 / l, Age, 18 - 45 years, Previously treated, failure, intolerance, first - line therapy, relapse, after first - line therapy, corticosteroids, intravenous immunoglobulin, IVIG, anti - D immunoglobulins

NCT02760251_inc_task2

Sentence: Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Qualifier", "O", "B-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O" ]

Informed consent as documented by signature (see informed consent form) Primary ITP according to the definition of Rodeghiero et al. (52) and a platelet count of <30x109/l Age range: 18-45 years Previously treated patients, with failure or intolerance to first-line therapy, or relapse after first-line therapy, i.e. corticosteroids, intravenous immunoglobulin (IVIG), or anti-D immunoglobulins

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[ "Scope", "Drug", "Measurement", "Temporal", "Observation", "Procedure", "Reference_point", "Condition", "Value", "Qualifier", "Person" ]

Hoehe is an umlsterm, Verletzungen is an umlsterm, Beckens is an umlsterm, unteren Extremitaeten is an umlsterm, Schultergelenkluxation is an umlsterm, Verletzung is an umlsterm, Axilla is an umlsterm, Literatur is an umlsterm, Pathophysiologie is an umlsterm, Diagnostik is an umlsterm, Verletzung is an umlsterm, Weichteilverletzungen is an umlsterm

DerUnfallchirurg.60990801.ger.abstr_task0

Sentence: Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung .

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[ "umlsterm" ]

Hoehe is an umlsterm, Verletzungen is an umlsterm, Beckens is an umlsterm, unteren Extremitaeten is an umlsterm, Schultergelenkluxation is an umlsterm, Verletzung is an umlsterm, Axilla is an umlsterm, Literatur is an umlsterm, Pathophysiologie is an umlsterm, Diagnostik is an umlsterm, Verletzung is an umlsterm, Weichteilverletzungen is an umlsterm

DerUnfallchirurg.60990801.ger.abstr_task1

Sentence: Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung . Instructions: please typing these entity words according to sentence: Hoehe, Verletzungen, Beckens, unteren Extremitaeten, Schultergelenkluxation, Verletzung, Axilla, Literatur, Pathophysiologie, Diagnostik, Verletzung, Weichteilverletzungen Options: umlsterm

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Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung .

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[ "umlsterm" ]

Hoehe, Verletzungen, Beckens, unteren Extremitaeten, Schultergelenkluxation, Verletzung, Axilla, Literatur, Pathophysiologie, Diagnostik, Verletzung, Weichteilverletzungen

DerUnfallchirurg.60990801.ger.abstr_task2

Sentence: Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Es wird der Fall eines 36jaehrigen Montagearbeiters beschrieben , der nach Sturz aus ca. 20 m Hoehe neben schweren Verletzungen des Abdomens , des Beckens sowie der oberen und unteren Extremitaeten eine beidseitige aufrechte , untere Schultergelenkluxation ( Luxatio erecta humeri ) erlitt . Rechtsseitig bestand eine infrakorakoidale Form , linksseitig eine infraglenoidale , II Grad offene Verletzung mit sichtbarem Humeruskopf in der Axilla . Anhand dieses Beispiels und der Literatur wird die Pathophysiologie , Diagnostik und Behandlungsstrategie dieser seltenen Verletzung dargestellt und diskutiert . Nach sofortiger geschlossener Reposition erfordert das Vorliegen von ausgedehnten Weichteilverletzungen , Begleitfrakturen bzw. neurovaskulaeren Laesionen die fruehestmoegliche operative Versorgung .

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[ "umlsterm" ]

Cyclosporin is an umlsterm, Herztransplantation is an umlsterm, Behandlung is an umlsterm, Nierenfunktion is an umlsterm, Herzempfaengern is an umlsterm, Methoden is an umlsterm, herztransplantierte is an umlsterm, Patienten is an umlsterm, Maenner is an umlsterm, Frauen is an umlsterm, Immunsuppression is an umlsterm, Azathioprin is an umlsterm, Steroide is an umlsterm, Kreatinin is an umlsterm, Kardiomyopathie is an umlsterm, Patienten is an umlsterm, Kardiomyopathie is an umlsterm, Patientenalter is an umlsterm, Azathioprin is an umlsterm, Kreatinin is an umlsterm, Harnsaeure is an umlsterm, Patienten is an umlsterm

ZfuerHerzThoraxGefaesschirurgie.9013s032.ger.abstr_task0

Sentence: Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF .

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[ "umlsterm" ]

Cyclosporin is an umlsterm, Herztransplantation is an umlsterm, Behandlung is an umlsterm, Nierenfunktion is an umlsterm, Herzempfaengern is an umlsterm, Methoden is an umlsterm, herztransplantierte is an umlsterm, Patienten is an umlsterm, Maenner is an umlsterm, Frauen is an umlsterm, Immunsuppression is an umlsterm, Azathioprin is an umlsterm, Steroide is an umlsterm, Kreatinin is an umlsterm, Kardiomyopathie is an umlsterm, Patienten is an umlsterm, Kardiomyopathie is an umlsterm, Patientenalter is an umlsterm, Azathioprin is an umlsterm, Kreatinin is an umlsterm, Harnsaeure is an umlsterm, Patienten is an umlsterm

ZfuerHerzThoraxGefaesschirurgie.9013s032.ger.abstr_task1

Sentence: Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF . Instructions: please typing these entity words according to sentence: Cyclosporin, Herztransplantation, Behandlung, Nierenfunktion, Herzempfaengern, Methoden, herztransplantierte, Patienten, Maenner, Frauen, Immunsuppression, Azathioprin, Steroide, Kreatinin, Kardiomyopathie, Patienten, Kardiomyopathie, Patientenalter, Azathioprin, Kreatinin, Harnsaeure, Patienten Options: umlsterm

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Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF .

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[ "umlsterm" ]

Cyclosporin, Herztransplantation, Behandlung, Nierenfunktion, Herzempfaengern, Methoden, herztransplantierte, Patienten, Maenner, Frauen, Immunsuppression, Azathioprin, Steroide, Kreatinin, Kardiomyopathie, Patienten, Kardiomyopathie, Patientenalter, Azathioprin, Kreatinin, Harnsaeure, Patienten

ZfuerHerzThoraxGefaesschirurgie.9013s032.ger.abstr_task2

Sentence: Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF . Instructions: please extract entity words from the input sentence

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Cyclosporin ( CSA ) Nephrotoxizitaet ist ein haeufiges Problem nach Herztransplantation . Wir untersuchten den Effekt einer CSA-Dosisreduktion in Verbindung mit einer Mycophenolat Mofetil ( MMF ) Behandlung auf die Nierenfunktion von Herzempfaengern mit CSA-Nephrotoxizitaet ( Serum-Kreatinin > 2mg/dl). Methoden : 14 herztransplantierte Patienten ( 12 Maenner , 2 Frauen ; 111 bis 1813 Tage nach HTX ) mit CSA-basierter Immunsuppression ( plus Azathioprin und/oder Steroide ) und einem Serum Kreatinin > 2mg/dl wurden mit einer Tagesdosis von 2000mg MMF behandelt . Eine dilatative Kardiomyopathie war bei 10 Patienten die Grunderkrankung , eine ischaemische Kardiomyopathie bei 4. Das mittlere Patientenalter betrug 57 Jahre ( 44-69 Jahre ) . Azathioprin wurde abgesetzt und CSA langsam reduziert . Kreatinin-Clearance , Serum Kreatinin , Harnstoff-N und Harnsaeure wurden kontrolliert . Cyclosporin-Spiegel wurden gemessen und die Dosis auf Zielspiegel von 70-120µg/l eingestellt . 12 Patienten hatten Endomyokardbiopsien 2 , nur noch echokardiographische Kontrollen . Ergebnisse : Zwei Abstossungen Grad 1B nach ISHLT wurden beobachtet innerhalb von einem Jahr nach Wechsel zu MMF .

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[ "umlsterm" ]

Abgeschlagenheit is an umlsterm, Ermuedung is an umlsterm, Patienten is an umlsterm, Sklerose is an umlsterm, Belastbarkeit is an umlsterm, Patienten is an umlsterm, Ruhepausen is an umlsterm, Entzuendungsmediatoren is an umlsterm, Medikamente is an umlsterm, Amantadin is an umlsterm, Therapieansaetze is an umlsterm, Aminopyridine is an umlsterm, 4-Aminopyridin is an umlsterm, epileptische Anfaelle is an umlsterm

DerNervenarzt.90700566.ger.abstr_task0

Sentence: " Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O" ]

" Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten .

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[ "umlsterm" ]

Abgeschlagenheit is an umlsterm, Ermuedung is an umlsterm, Patienten is an umlsterm, Sklerose is an umlsterm, Belastbarkeit is an umlsterm, Patienten is an umlsterm, Ruhepausen is an umlsterm, Entzuendungsmediatoren is an umlsterm, Medikamente is an umlsterm, Amantadin is an umlsterm, Therapieansaetze is an umlsterm, Aminopyridine is an umlsterm, 4-Aminopyridin is an umlsterm, epileptische Anfaelle is an umlsterm

DerNervenarzt.90700566.ger.abstr_task1

Sentence: " Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten . Instructions: please typing these entity words according to sentence: Abgeschlagenheit, Ermuedung, Patienten, Sklerose, Belastbarkeit, Patienten, Ruhepausen, Entzuendungsmediatoren, Medikamente, Amantadin, Therapieansaetze, Aminopyridine, 4-Aminopyridin, epileptische Anfaelle Options: umlsterm

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" Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten .

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[ "umlsterm" ]

Abgeschlagenheit, Ermuedung, Patienten, Sklerose, Belastbarkeit, Patienten, Ruhepausen, Entzuendungsmediatoren, Medikamente, Amantadin, Therapieansaetze, Aminopyridine, 4-Aminopyridin, epileptische Anfaelle

DerNervenarzt.90700566.ger.abstr_task2

Sentence: " Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten . Instructions: please extract entity words from the input sentence

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" Fatigue " ( Erschoepfung Abgeschlagenheit , Ermuedung ) , ist ein haeufiges Symptom bei Patienten mit multipler Sklerose . Die uebermaessige Erschoepfung und verminderte Belastbarkeit fuehrt bei vielen Patienten zu Schwierigkeiten , einen normalen Tagesablauf zu bewaeltigen . Durch Ruhepausen kann die Fatigue nur zum Teil kompensiert werden . Die pathophysiologischen Mechanismen der Fatigue sind bisher nicht geklaert . Als Ursache kommen neben der direkten Schaedigung strategisch wichtiger neuroanatomischer Regionen auch generalisierte Effekte von Entzuendungsmediatoren in Betracht . Fuer einige Medikamente wie z.B. Amantadin konnte ein positiver Einfluss auf die Fatigue gezeigt werden . Als neue Therapieansaetze werden in der Zwischenzeit Aminopyridine ( 4-Aminopyridin und 3,4-Diaminopyridin ) eingesetzt . Neben einer Verbesserung der Nervenleitfaehigkeit haben diese beiden Substanzen wahrscheinlich einen zentral stimulierenden Effekt . Bei Ueberdosierung koennen deswegen epileptische Anfaelle und Verwirrtheitszustaende auftreten .

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[ "umlsterm" ]

soybeans is a Plant, cancer is a Disease, soybean is a Plant, soybean is a Plant, soybean is a Plant, Soybean is a Plant, soybean is a Plant, soybean is a Plant, cancer is a Disease, cancers is a Disease, soybean is a Plant, cancer is a Disease

7884559_task0

Sentence: There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Disease, Plant

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There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates.

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[ "Plant", "Disease" ]

soybeans is a Plant, cancer is a Disease, soybean is a Plant, soybean is a Plant, soybean is a Plant, Soybean is a Plant, soybean is a Plant, soybean is a Plant, cancer is a Disease, cancers is a Disease, soybean is a Plant, cancer is a Disease

7884559_task1

Sentence: There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates. Instructions: please typing these entity words according to sentence: soybeans, cancer, soybean, soybean, soybean, Soybean, soybean, soybean, cancer, cancers, soybean, cancer Options: Disease, Plant

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]

There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates.

[ "There", "is", "much", "evidence", "suggesting", "that", "compounds", "present", "in", "soybeans", "can", "prevent", "cancer", "in", "many", "different", "organ", "systems", ".", "The", "evidence", "for", "specific", "soybean", "-", "derived", "compounds", "having", "a", "suppressive", "effect", "on", "carcinogenesis", "in", "animal", "model", "systems", "is", "limited", ",", "however", ".", "There", "is", "evidence", "that", "the", "following", "isolated", "soybean", "derived", "products", "suppress", "carcinogenesis", "in", "vivo", ":", "a", "protease", "inhibitor", ",", "the", "Bowman", "-", "Birk", "inhibitor", ",", "inositol", "hexaphosphate", "(", "phytic", "acid", ")", "and", "the", "sterol", "beta", "-", "sitosterol", ".", "Other", "compounds", "that", "may", "be", "able", "to", "suppress", "carcinogenesis", "in", "animals", "are", "the", "soybean", "isoflavones", ".", "Soybean", "compounds", "reported", "to", "have", "other", "types", "of", "anticarcinogenic", "activity", "include", "soybean", "trypsin", "inhibitor", ",", "saponins", "and", "genistein", ".", "There", "is", "much", "evidence", "to", "suggest", "that", "diets", "containing", "large", "amounts", "of", "soybean", "products", "are", "associated", "with", "overall", "low", "cancer", "mortality", "rates", ",", "particularly", "for", "cancers", "of", "the", "colon", ",", "breast", "and", "prostate", ".", "It", "is", "believed", "that", "supplementation", "of", "human", "diets", "with", "certain", "soybean", "products", "shown", "to", "suppress", "carcinogenesis", "in", "animals", "could", "markedly", "reduce", "human", "cancer", "mortality", "rates", "." ]

[ "Plant", "Disease" ]

soybeans, cancer, soybean, soybean, soybean, Soybean, soybean, soybean, cancer, cancers, soybean, cancer

7884559_task2

Sentence: There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Plant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Disease", "O", "O", "O" ]

There is much evidence suggesting that compounds present in soybeans can prevent cancer in many different organ systems. The evidence for specific soybean-derived compounds having a suppressive effect on carcinogenesis in animal model systems is limited, however. There is evidence that the following isolated soybean derived products suppress carcinogenesis in vivo: a protease inhibitor, the Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid) and the sterol beta-sitosterol. Other compounds that may be able to suppress carcinogenesis in animals are the soybean isoflavones. Soybean compounds reported to have other types of anticarcinogenic activity include soybean trypsin inhibitor, saponins and genistein. There is much evidence to suggest that diets containing large amounts of soybean products are associated with overall low cancer mortality rates, particularly for cancers of the colon, breast and prostate. It is believed that supplementation of human diets with certain soybean products shown to suppress carcinogenesis in animals could markedly reduce human cancer mortality rates.

[ "There", "is", "much", "evidence", "suggesting", "that", "compounds", "present", "in", "soybeans", "can", "prevent", "cancer", "in", "many", "different", "organ", "systems", ".", "The", "evidence", "for", "specific", "soybean", "-", "derived", "compounds", "having", "a", "suppressive", "effect", "on", "carcinogenesis", "in", "animal", "model", "systems", "is", "limited", ",", "however", ".", "There", "is", "evidence", "that", "the", "following", "isolated", "soybean", "derived", "products", "suppress", "carcinogenesis", "in", "vivo", ":", "a", "protease", "inhibitor", ",", "the", "Bowman", "-", "Birk", "inhibitor", ",", "inositol", "hexaphosphate", "(", "phytic", "acid", ")", "and", "the", "sterol", "beta", "-", "sitosterol", ".", "Other", "compounds", "that", "may", "be", "able", "to", "suppress", "carcinogenesis", "in", "animals", "are", "the", "soybean", "isoflavones", ".", "Soybean", "compounds", "reported", "to", "have", "other", "types", "of", "anticarcinogenic", "activity", "include", "soybean", "trypsin", "inhibitor", ",", "saponins", "and", "genistein", ".", "There", "is", "much", "evidence", "to", "suggest", "that", "diets", "containing", "large", "amounts", "of", "soybean", "products", "are", "associated", "with", "overall", "low", "cancer", "mortality", "rates", ",", "particularly", "for", "cancers", "of", "the", "colon", ",", "breast", "and", "prostate", ".", "It", "is", "believed", "that", "supplementation", "of", "human", "diets", "with", "certain", "soybean", "products", "shown", "to", "suppress", "carcinogenesis", "in", "animals", "could", "markedly", "reduce", "human", "cancer", "mortality", "rates", "." ]

[ "Plant", "Disease" ]

HIV-1 parasitism is an other_name, T cells is a cell_type, nuclear factor of activated T cells is a protein_family_or_group

69245_task0

Sentence: Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, protein_family_or_group, other_name

[ "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O" ]

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.

[ "Host", "control", "of", "HIV-1", "parasitism", "in", "T", "cells", "by", "the", "nuclear", "factor", "of", "activated", "T", "cells", "." ]

[ "protein_family_or_group", "other_name", "cell_type", "virus", "protein_molecule", "other_organic_compound" ]

HIV-1 parasitism is an other_name, T cells is a cell_type, nuclear factor of activated T cells is a protein_family_or_group

69245_task1

Sentence: Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Instructions: please typing these entity words according to sentence: HIV-1 parasitism, T cells, nuclear factor of activated T cells Options: cell_type, protein_family_or_group, other_name

[ "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O" ]

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.

[ "Host", "control", "of", "HIV-1", "parasitism", "in", "T", "cells", "by", "the", "nuclear", "factor", "of", "activated", "T", "cells", "." ]

[ "protein_family_or_group", "other_name", "cell_type", "virus", "protein_molecule", "other_organic_compound" ]

HIV-1 parasitism, T cells, nuclear factor of activated T cells

69245_task2

Sentence: Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-other_name", "I-other_name", "O", "B-cell_type", "I-cell_type", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "O" ]

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.

[ "Host", "control", "of", "HIV-1", "parasitism", "in", "T", "cells", "by", "the", "nuclear", "factor", "of", "activated", "T", "cells", "." ]

[ "protein_family_or_group", "other_name", "cell_type", "virus", "protein_molecule", "other_organic_compound" ]

Patienten is an umlsterm, Sarkoidose is an umlsterm, Autopsieberichte is an umlsterm, Zentralnervensystems is an umlsterm, Beurteilung is an umlsterm, Magnetresonanztomographie is an umlsterm, Diagnostik is an umlsterm, Patienten is an umlsterm, Sarkoidose is an umlsterm, Fazialisparese is an umlsterm, Patienten is an umlsterm, Marklagerlaesionen is an umlsterm, Kontrastmittelanreicherung is an umlsterm

DerRadiologe.90390889.ger.abstr_task0

Sentence: Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% .

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[ "umlsterm" ]

Patienten is an umlsterm, Sarkoidose is an umlsterm, Autopsieberichte is an umlsterm, Zentralnervensystems is an umlsterm, Beurteilung is an umlsterm, Magnetresonanztomographie is an umlsterm, Diagnostik is an umlsterm, Patienten is an umlsterm, Sarkoidose is an umlsterm, Fazialisparese is an umlsterm, Patienten is an umlsterm, Marklagerlaesionen is an umlsterm, Kontrastmittelanreicherung is an umlsterm

DerRadiologe.90390889.ger.abstr_task1

Sentence: Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% . Instructions: please typing these entity words according to sentence: Patienten, Sarkoidose, Autopsieberichte, Zentralnervensystems, Beurteilung, Magnetresonanztomographie, Diagnostik, Patienten, Sarkoidose, Fazialisparese, Patienten, Marklagerlaesionen, Kontrastmittelanreicherung Options: umlsterm

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Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% .

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[ "umlsterm" ]

Patienten, Sarkoidose, Autopsieberichte, Zentralnervensystems, Beurteilung, Magnetresonanztomographie, Diagnostik, Patienten, Sarkoidose, Fazialisparese, Patienten, Marklagerlaesionen, Kontrastmittelanreicherung

DerRadiologe.90390889.ger.abstr_task2

Sentence: Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Klinische Untersuchungen an Patienten mit systemischer Sarkoidose sprechen in 5% , Autopsieberichte in 25% fuer eine Beteiligung des Zentralnervensystems . Ziel der Studie ist eine Beurteilung der Beitrags der Magnetresonanztomographie ( MRT ) in der Diagnostik der Neurosarkoidose . Die MR-Tomogramme von 22 Patienten mit gesicherter Sarkoidose und neurologischer Symptomatik wurden retrospektiv ausgewertet . Haeufigstes klinisches Symptom der Neurosarkoidose war eine Fazialisparese ( 10 Patienten ) . MR-tomographisch konnte eine Vielzahl verschiedener Befunde erhoben werden : periventrikulaere und Marklagerlaesionen in T2-gewichteten Bildern in 46% , multiple bzw. miliare supratentorielle und infratentorielle Laesionen in 36% , solitaere intraaxiale Raumforderungen in 9% , solitaere extraaxiale Raumforderungen in 5% und meningeale Kontrastmittelanreicherung ( nodulaer oder diffus ) in 36% .

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[ "umlsterm" ]

celecoxib is a compound, Akt is a protein

DS.d1370_task0

Sentence: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]

Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.

[ "Anti", "-", "gastric", "cancer", "effects", "of", "celecoxib", ",", "a", "selective", "COX-2", "inhibitor", ",", "through", "inhibition", "of", "Akt", "signaling", "." ]

[ "compound", "protein" ]

celecoxib is a compound, Akt is a protein

DS.d1370_task1

Sentence: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. Instructions: please typing these entity words according to sentence: celecoxib, Akt Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]

Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.

[ "Anti", "-", "gastric", "cancer", "effects", "of", "celecoxib", ",", "a", "selective", "COX-2", "inhibitor", ",", "through", "inhibition", "of", "Akt", "signaling", "." ]

[ "compound", "protein" ]

celecoxib, Akt

DS.d1370_task2

Sentence: Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O" ]

Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling.

[ "Anti", "-", "gastric", "cancer", "effects", "of", "celecoxib", ",", "a", "selective", "COX-2", "inhibitor", ",", "through", "inhibition", "of", "Akt", "signaling", "." ]

[ "compound", "protein" ]

city is an umlsterm, son is an umlsterm, Theodor is an umlsterm, head is an umlsterm, district hospital is an umlsterm, medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, dermatology is an umlsterm, period is an umlsterm, president is an umlsterm, Dermatology is an umlsterm, Association is an umlsterm, death is an umlsterm, city hospital is an umlsterm, War is an umlsterm, all is an umlsterm, medical facilities is an umlsterm, dermatology is an umlsterm, army hospital is an umlsterm, dermatology is an umlsterm, hospital is an umlsterm

DerHautarzt.70480762.eng.abstr_task0

Sentence: In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital .

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[ "umlsterm" ]

city is an umlsterm, son is an umlsterm, Theodor is an umlsterm, head is an umlsterm, district hospital is an umlsterm, medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, dermatology is an umlsterm, period is an umlsterm, president is an umlsterm, Dermatology is an umlsterm, Association is an umlsterm, death is an umlsterm, city hospital is an umlsterm, War is an umlsterm, all is an umlsterm, medical facilities is an umlsterm, dermatology is an umlsterm, army hospital is an umlsterm, dermatology is an umlsterm, hospital is an umlsterm

DerHautarzt.70480762.eng.abstr_task1

Sentence: In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital . Instructions: please typing these entity words according to sentence: city, son, Theodor, head, district hospital, medicine, dermatology, development, dermatology, period, president, Dermatology, Association, death, city hospital, War, all, medical facilities, dermatology, army hospital, dermatology, hospital Options: umlsterm

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In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital .

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[ "umlsterm" ]

city, son, Theodor, head, district hospital, medicine, dermatology, development, dermatology, period, president, Dermatology, Association, death, city hospital, War, all, medical facilities, dermatology, army hospital, dermatology, hospital

DerHautarzt.70480762.eng.abstr_task2

Sentence: In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital . Instructions: please extract entity words from the input sentence

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In 1837 , Germany's first in-patient dermatological department named " Heilanstalt fuer Flechtenkranke " was founded by Dr. Albert Friedrich Veiel in the city of Cannstatt ( which since 1905 is part of Stuttgart ) . Later his son , Dr. Theodor Veiel , directed this private dermatological clinic , and became head of the district hospital of Cannstatt in 1881. Although he was active in many areas of medicine , dermatology was his main interest . He very much influenced the development of dermatology during his period as president of the German Dermatology Association until his death in 1923. In 1935 , the first dermatological city hospital was established in Cannstatt/Stuttgart . But , after World War II , all the medical facilities were taken over by the US Army . Thus , medical activities including dermatology had to be spread all over Stuttgart , until in 1965 they were returned to their former place . At the end of 1998 , the large abandoned US army hospital will home a totally renovated and modernized Stuttgart dermatology hospital .

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[ "umlsterm" ]

nicotine is an intervention, cardiovascular or lipid stress reactivity is an outcome, women is a participant

90_task0

Sentence: These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: intervention, participant, outcome

[ "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "B-participant", "O" ]

These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .

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[ "outcome", "intervention", "participant" ]

nicotine is an intervention, cardiovascular or lipid stress reactivity is an outcome, women is a participant

90_task1

Sentence: These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women . Instructions: please typing these entity words according to sentence: nicotine, cardiovascular or lipid stress reactivity, women Options: intervention, participant, outcome

[ "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "B-participant", "O" ]

These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .

[ "These", "data", "show", "that", "acute", "nicotine", "administration", ",", "in", "the", "form", "of", "nicotine", "gum", ",", "has", "no", "effect", "on", "cardiovascular", "or", "lipid", "stress", "reactivity", "in", "women", "." ]

[ "outcome", "intervention", "participant" ]

nicotine, cardiovascular or lipid stress reactivity, women

90_task2

Sentence: These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-outcome", "I-outcome", "I-outcome", "I-outcome", "I-outcome", "O", "B-participant", "O" ]

These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .

[ "These", "data", "show", "that", "acute", "nicotine", "administration", ",", "in", "the", "form", "of", "nicotine", "gum", ",", "has", "no", "effect", "on", "cardiovascular", "or", "lipid", "stress", "reactivity", "in", "women", "." ]

[ "outcome", "intervention", "participant" ]

PSK is a Intervention_Pharmacological, CD57 ( + ) T cells is a Outcome_Physical, oral adjuvant immunochemotherapy is a Intervention_Pharmacological, protein - bound polysaccharide K ( PSK ) is a Intervention_Pharmacological, tegafur / uracil ( UFT ) is a Intervention_Pharmacological, UFT alone is a Intervention_Pharmacological, immunological parameters is a Outcome_Physical, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells is a Outcome_Physical, PSK plus 300 mg UFT ( PSK group ) is a Intervention_Pharmacological, control is a Intervention_Control, 3-year overall survival is a Outcome_Mortality, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T is a Outcome_Physical, 3-year survival is a Outcome_Mortality, PSK + UFT is a Intervention_Pharmacological

44924_task0

Sentence: PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mortality

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PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Mortality", "Intervention_Control" ]

PSK is a Intervention_Pharmacological, CD57 ( + ) T cells is a Outcome_Physical, oral adjuvant immunochemotherapy is a Intervention_Pharmacological, protein - bound polysaccharide K ( PSK ) is a Intervention_Pharmacological, tegafur / uracil ( UFT ) is a Intervention_Pharmacological, UFT alone is a Intervention_Pharmacological, immunological parameters is a Outcome_Physical, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells is a Outcome_Physical, PSK plus 300 mg UFT ( PSK group ) is a Intervention_Pharmacological, control is a Intervention_Control, 3-year overall survival is a Outcome_Mortality, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T is a Outcome_Physical, 3-year survival is a Outcome_Mortality, PSK + UFT is a Intervention_Pharmacological

44924_task1

Sentence: PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer . Instructions: please typing these entity words according to sentence: PSK, CD57 ( + ) T cells, oral adjuvant immunochemotherapy, protein - bound polysaccharide K ( PSK ), tegafur / uracil ( UFT ), UFT alone, immunological parameters, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells, PSK plus 300 mg UFT ( PSK group ), control, 3-year overall survival, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T, 3-year survival, PSK + UFT Options: Intervention_Pharmacological, Outcome_Physical, Intervention_Control, Outcome_Mortality

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PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer .

[ "PSK", "may", "suppress", "CD57", "(", "+", ")", "T", "cells", "to", "improve", "survival", "of", "advanced", "gastric", "cancer", "patients", ".", "BACKGROUND", "A", "recent", "report", "showed", "that", "oral", "adjuvant", "immunochemotherapy", "with", "protein", "-", "bound", "polysaccharide", "K", "(", "PSK", ")", "and", "tegafur", "/", "uracil", "(", "UFT", ")", "for", "stage", "II", "and", "III", "colorectal", "cancer", "improves", "overall", "survival", "compared", "with", "UFT", "alone", ".", "PSK", "has", "been", "supposed", "to", "improve", "survival", "through", "immunological", "mechanisms", "such", "as", "induction", "of", "cytokines", ",", "regulation", "of", "Th1", "/", "Th2", "balance", ",", "and", "inhibition", "of", "immunosuppressive", "molecules", ".", "METHODS", "We", "investigated", "the", "mechanisms", "by", "which", "PSK", "influences", "immunological", "parameters", "such", "as", "Th1", "cells", "(", "IFN", "-", "gamma", "-", "positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th2", "cells", "(", "IL-4-positive", "CD4", "(", "+", ")", "T", "cells", ")", ",", "Th1", "/", "Th2", "ratio", ",", "NKT", "cells", "(", "CD56", "(", "+", ")", "T", "cells", "and", "CD57", "(", "+", ")", "T", "cells", ")", ",", "NK", "cells", ",", "and", "CD25", "(", "+", ")", "CD4", "(", "+", ")", "T", "cells", "in", "stage", "III", "gastric", "cancer", "patients", ".", "Patients", "were", "randomly", "assigned", "to", "receive", "either", "3", "g", "PSK", "plus", "300", "mg", "UFT", "(", "PSK", "group", ")", "or", "300", "mg", "UFT", "alone", "(", "control", ")", "orally", "each", "day", "for", "at", "least", "1", "year", "following", "their", "operation", ".", "RESULTS", "Twenty", "-", "one", "registered", "patients", "with", "stage", "III", "gastric", "cancer", "were", "analyzed", ".", "The", "3-year", "overall", "survival", "was", "62.2", "%", "in", "the", "PSK", "group", "(", "n", "=", "10", ")", "and", "12.5", "%", "in", "the", "control", "group", "(", "n", "=", "11", ")", "(", "P", "=", "0.038", ")", ".", "Before", "operation", ",", "there", "were", "no", "significant", "differences", "in", "the", "proportions", "of", "Th1", "cells", ",", "Th2", "cells", ",", "Th1", "/", "Th2", "ratio", ",", "CD56", "(", "+", ")", "T", "cells", ",", "CD57", "(", "+", ")", "T", "cells", ",", "NK", "cells", ",", "and", "CD4", "(", "+", ")", "CD25", "(", "+", ")", "T", "cells", "between", "PSK", "and", "control", "groups", ".", "However", ",", "after", "operation", ",", "CD57", "(", "+", ")", "T", "cells", "decreased", "significantly", "in", "the", "PSK", "group", "compared", "to", "the", "control", "(", "P", "=", "0.0486", ")", ".", "When", "all", "patients", "were", "analyzed", ",", "patients", "with", "increased", "proportion", "(", ">", "18", "%", ")", "of", "CD57", "(", "+", ")", "T", "cells", "showed", "worse", "survival", "than", "those", "with", "lower", "(", "<", "or", "=", "18", "%", ")", "CD57", "(", "+", ")", "T", "cells", "(", "3-year", "survival", ",", "25.0", "and", "45.7", "%", ",", "respectively", ";", "P", "=", "0.046", ")", ",", "consistent", "with", "our", "previous", "report", "that", "high", "CD57", "(", "+", ")", "is", "an", "indicator", "of", "poor", "prognosis", "in", "patients", "with", "advanced", "gastric", "cancer", ".", "However", ",", "in", "the", "group", "treated", "with", "PSK", "+", "UFT", ",", "3-year", "survival", "of", "CD57-high", "patients", "was", "as", "great", "as", "that", "of", "CD57-low", "patients", "(", "66.7", "and", "51.4", "%", ",", "respectively", ";", "P", "=", "0.67", ")", ".", "CONCLUSION", "The", "present", "findings", "suggest", "that", "PSK", "improves", "overall", "survival", "of", "stage", "III", "gastric", "cancer", "patients", "partly", "by", "inhibiting", "CD57", "(", "+", ")", "T", "cells", ",", "a", "proven", "poor", "prognostic", "factor", "in", "advanced", "gastric", "cancer", "." ]

[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Mortality", "Intervention_Control" ]

PSK, CD57 ( + ) T cells, oral adjuvant immunochemotherapy, protein - bound polysaccharide K ( PSK ), tegafur / uracil ( UFT ), UFT alone, immunological parameters, Th1 cells ( IFN - gamma - positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1 / Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells, PSK plus 300 mg UFT ( PSK group ), control, 3-year overall survival, Th1 cells , Th2 cells , Th1 / Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T, 3-year survival, PSK + UFT

44924_task2

Sentence: PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer . Instructions: please extract entity words from the input sentence

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"I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", 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PSK may suppress CD57 ( + ) T cells to improve survival of advanced gastric cancer patients . BACKGROUND A recent report showed that oral adjuvant immunochemotherapy with protein-bound polysaccharide K ( PSK ) and tegafur/uracil ( UFT ) for stage II and III colorectal cancer improves overall survival compared with UFT alone . PSK has been supposed to improve survival through immunological mechanisms such as induction of cytokines , regulation of Th1/Th2 balance , and inhibition of immunosuppressive molecules . METHODS We investigated the mechanisms by which PSK influences immunological parameters such as Th1 cells ( IFN-gamma-positive CD4 ( + ) T cells ) , Th2 cells ( IL-4-positive CD4 ( + ) T cells ) , Th1/Th2 ratio , NKT cells ( CD56 ( + ) T cells and CD57 ( + ) T cells ) , NK cells , and CD25 ( + ) CD4 ( + ) T cells in stage III gastric cancer patients . Patients were randomly assigned to receive either 3 g PSK plus 300 mg UFT ( PSK group ) or 300 mg UFT alone ( control ) orally each day for at least 1 year following their operation . RESULTS Twenty-one registered patients with stage III gastric cancer were analyzed . The 3-year overall survival was 62.2 % in the PSK group ( n = 10 ) and 12.5 % in the control group ( n = 11 ) ( P = 0.038 ) . Before operation , there were no significant differences in the proportions of Th1 cells , Th2 cells , Th1/Th2 ratio , CD56 ( + ) T cells , CD57 ( + ) T cells , NK cells , and CD4 ( + ) CD25 ( + ) T cells between PSK and control groups . However , after operation , CD57 ( + ) T cells decreased significantly in the PSK group compared to the control ( P = 0.0486 ) . When all patients were analyzed , patients with increased proportion ( > 18 % ) of CD57 ( + ) T cells showed worse survival than those with lower ( < or = 18 % ) CD57 ( + ) T cells ( 3-year survival , 25.0 and 45.7 % , respectively ; P = 0.046 ) , consistent with our previous report that high CD57 ( + ) is an indicator of poor prognosis in patients with advanced gastric cancer . However , in the group treated with PSK + UFT , 3-year survival of CD57-high patients was as great as that of CD57-low patients ( 66.7 and 51.4 % , respectively ; P = 0.67 ) . CONCLUSION The present findings suggest that PSK improves overall survival of stage III gastric cancer patients partly by inhibiting CD57 ( + ) T cells , a proven poor prognostic factor in advanced gastric cancer .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Outcome_Mortality", "Intervention_Control" ]

treatment is an umlsterm, patients is an umlsterm, burn injuries is an umlsterm, hands is an umlsterm, patients is an umlsterm, June is an umlsterm, patients is an umlsterm, patients is an umlsterm, Patients is an umlsterm, ABSI is an umlsterm, mortality is an umlsterm, costs is an umlsterm, DM is an umlsterm, costs is an umlsterm, costs is an umlsterm, DM is an umlsterm, costs is an umlsterm, treatment is an umlsterm, DM is an umlsterm, costs is an umlsterm, DM is an umlsterm, laboratory is an umlsterm, DM is an umlsterm, blood bank is an umlsterm, DM is an umlsterm, costs is an umlsterm, analysis is an umlsterm, costs is an umlsterm, therapy is an umlsterm, analysis is an umlsterm, individuality is an umlsterm, patients is an umlsterm

DerUnfallchirurg.60990875.eng.abstr_task0

Sentence: The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients .

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[ "umlsterm" ]

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DerUnfallchirurg.60990875.eng.abstr_task1

Sentence: The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients . Instructions: please typing these entity words according to sentence: treatment, patients, burn injuries, hands, patients, June, patients, patients, Patients, ABSI, mortality, costs, DM, costs, costs, DM, costs, treatment, DM, costs, DM, laboratory, DM, blood bank, DM, costs, analysis, costs, therapy, analysis, individuality, patients Options: umlsterm

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The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients .

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[ "umlsterm" ]

treatment, patients, burn injuries, hands, patients, June, patients, patients, Patients, ABSI, mortality, costs, DM, costs, costs, DM, costs, treatment, DM, costs, DM, laboratory, DM, blood bank, DM, costs, analysis, costs, therapy, analysis, individuality, patients

DerUnfallchirurg.60990875.eng.abstr_task2

Sentence: The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The treatment of patients with severe burn injuries is expensive and belongs in the hands of specialized burn centres . In our burn centre 257 patients were treated from 1991 to June 1995 ( between 50 and 60 patients per year except for 1993 with 77 patients ) . Patients were evaluated according to the ABSI score ( mean 7 ) and had mortality of around 15% . The costs range between 3.7 and 4.8 million DM per year , the profit lies in the same range . The costs are divided into staff costs ( 1.4 - 1.8 million DM per year ) , costs for medical treatment ( 1.5 - 1.9 million DM per year ) and costs for internal services ( 600 000 - 900 000 DM per year ) such as laboratory examinations ( 247 000 - 386 000 DM per year ) and blood bank ( 100 000 - 215 000 DM per year ) , the main factors in this category . The different fields of costs and profit are compared in this analysis . Possible ways of reducing costs are pointed out , and the question of effectiveness of therapy is discussed . Conclusions from this analysis are limited by the individuality of each case with different clinical courses , the great number of influencing factors and the comparably small numbers of patients .

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[ "umlsterm" ]

NF - ATc is a protein_molecule, NF - ATp is a protein_molecule, cytoplasmic components is a cell_component

19289_task0

Sentence: Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_component, protein_molecule

[ "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "O" ]

Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.

[ "Cloning", "and", "characterization", "of", "NF", "-", "ATc", "and", "NF", "-", "ATp", ":", "the", "cytoplasmic", "components", "of", "NF", "-", "AT", "." ]

[ "protein_complex", "protein_family_or_group", "cell_component", "atom", "other_name", "protein_domain_or_region", "other_organic_compound", "protein_molecule", "cell_type" ]

NF - ATc is a protein_molecule, NF - ATp is a protein_molecule, cytoplasmic components is a cell_component

19289_task1

Sentence: Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Instructions: please typing these entity words according to sentence: NF - ATc, NF - ATp, cytoplasmic components Options: cell_component, protein_molecule

[ "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "O" ]

Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.

[ "Cloning", "and", "characterization", "of", "NF", "-", "ATc", "and", "NF", "-", "ATp", ":", "the", "cytoplasmic", "components", "of", "NF", "-", "AT", "." ]

[ "protein_complex", "protein_family_or_group", "cell_component", "atom", "other_name", "protein_domain_or_region", "other_organic_compound", "protein_molecule", "cell_type" ]

NF - ATc, NF - ATp, cytoplasmic components

19289_task2

Sentence: Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "B-cell_component", "I-cell_component", "O", "O", "O", "O", "O" ]

Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.

[ "Cloning", "and", "characterization", "of", "NF", "-", "ATc", "and", "NF", "-", "ATp", ":", "the", "cytoplasmic", "components", "of", "NF", "-", "AT", "." ]

[ "protein_complex", "protein_family_or_group", "cell_component", "atom", "other_name", "protein_domain_or_region", "other_organic_compound", "protein_molecule", "cell_type" ]

extraocular muscles is an umlsterm, patients is an umlsterm, thyroid - associated ophthalmopathy is an umlsterm, TAO is an umlsterm

DerOpthalmologe.70940290.eng.abstr_task0

Sentence: Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O" ]

Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) .

[ "Background", ":", "To", "determine", "the", "functional", "changes", "in", "the", "extraocular", "muscles", "in", "patients", "with", "thyroid", "-", "associated", "ophthalmopathy", "(", "TAO", ")", "." ]

[ "umlsterm" ]

extraocular muscles is an umlsterm, patients is an umlsterm, thyroid - associated ophthalmopathy is an umlsterm, TAO is an umlsterm

DerOpthalmologe.70940290.eng.abstr_task1

Sentence: Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) . Instructions: please typing these entity words according to sentence: extraocular muscles, patients, thyroid - associated ophthalmopathy, TAO Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O" ]

Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) .

[ "Background", ":", "To", "determine", "the", "functional", "changes", "in", "the", "extraocular", "muscles", "in", "patients", "with", "thyroid", "-", "associated", "ophthalmopathy", "(", "TAO", ")", "." ]

[ "umlsterm" ]

extraocular muscles, patients, thyroid - associated ophthalmopathy, TAO

DerOpthalmologe.70940290.eng.abstr_task2

Sentence: Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O" ]

Background : To determine the functional changes in the extraocular muscles in patients with thyroid-associated ophthalmopathy ( TAO ) .

[ "Background", ":", "To", "determine", "the", "functional", "changes", "in", "the", "extraocular", "muscles", "in", "patients", "with", "thyroid", "-", "associated", "ophthalmopathy", "(", "TAO", ")", "." ]

[ "umlsterm" ]

surgical is an umlsterm, malignant is an umlsterm, choroid is an umlsterm, melanoma is an umlsterm, systolic is an umlsterm, blood pressure is an umlsterm, choroidal haemorrhages is an umlsterm, blood pressure is an umlsterm, risk of is an umlsterm, cerebral ischaemia is an umlsterm, patient is an umlsterm, malignant is an umlsterm, choroid is an umlsterm, melanoma is an umlsterm, brainstem is an umlsterm, auditory evoked potentials is an umlsterm, surgery is an umlsterm, arterial hypotension is an umlsterm, hypothermia is an umlsterm, pressure is an umlsterm, oesophageal is an umlsterm, temperature is an umlsterm, time is an umlsterm, electroencephalogram is an umlsterm, EEG is an umlsterm, time is an umlsterm, period is an umlsterm, arterial hypotension is an umlsterm, EEG is an umlsterm, knowledge is an umlsterm, literature is an umlsterm, maintenance is an umlsterm, literature is an umlsterm, acoustic neurinoma is an umlsterm, patients is an umlsterm, patient is an umlsterm, artery is an umlsterm, anatomic is an umlsterm, blood supply is an umlsterm, stenosis is an umlsterm, basilar artery is an umlsterm, cause is an umlsterm, induced hypothermia is an umlsterm, temperature is an umlsterm

DerAnaesthesist.50440785.eng.abstr_task0

Sentence: For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss .

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[ "umlsterm" ]

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DerAnaesthesist.50440785.eng.abstr_task1

Sentence: For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss . Instructions: please typing these entity words according to sentence: surgical, malignant, choroid, melanoma, systolic, blood pressure, choroidal haemorrhages, blood pressure, risk of, cerebral ischaemia, patient, malignant, choroid, melanoma, brainstem, auditory evoked potentials, surgery, arterial hypotension, hypothermia, pressure, oesophageal, temperature, time, electroencephalogram, EEG, time, period, arterial hypotension, EEG, knowledge, literature, maintenance, literature, acoustic neurinoma, patients, patient, artery, anatomic, blood supply, stenosis, basilar artery, cause, induced hypothermia, temperature Options: umlsterm

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For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss .

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[ "umlsterm" ]

surgical, malignant, choroid, melanoma, systolic, blood pressure, choroidal haemorrhages, blood pressure, risk of, cerebral ischaemia, patient, malignant, choroid, melanoma, brainstem, auditory evoked potentials, surgery, arterial hypotension, hypothermia, pressure, oesophageal, temperature, time, electroencephalogram, EEG, time, period, arterial hypotension, EEG, knowledge, literature, maintenance, literature, acoustic neurinoma, patients, patient, artery, anatomic, blood supply, stenosis, basilar artery, cause, induced hypothermia, temperature

DerAnaesthesist.50440785.eng.abstr_task2

Sentence: For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss . Instructions: please extract entity words from the input sentence

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For surgical removal of a malignant choroid melanoma , it is necessary to reduce systolic blood pressure to around 50-60 mmHg in order to prevent choroidal haemorrhages . However , blood pressure reduction is associated with the risk of cerebral ischaemia . We report a patient with a malignant choroid melanoma in whom waves I and II of the brainstem auditory evoked potentials ( BAEP ) disappeared during surgery under controlled arterial hypotension and hypothermia ( 31.1 ° C ) . The waves could be recorded again immediately after the mean arterial pressure was increased from 48 to 77 mmHg . The oesophageal temperature had dropped by 0.3 ° C at this time . The 2-channel electroencephalogram ( EEG ) showed no irregularities during this time period . A bilateral , reversible , apparently blood-pressure-dependent loss of waves I and II during arterial hypotension despite a normal EEG has to our knowledge not been previously described in the literature . The isolated loss of waves I and II with maintenance of waves III , IV , and V is unusual . The literature contains reports of acoustic neurinoma patients in whom only wave V could be recorded . This is regarded as an indication of continued impulse conduction despite the loss of waves I to IV . Others have observed a patient with temporary and reversible loss of BAEP wave I due to vasospasm of the internal auditory artery that apparently occurred during or shortly after manipulation of the internal auditory meatus . Assuming anatomic peculiarities in the blood supply to the generators of the BAEP waves , a stenosis of the basilar artery could be considered as the cause of the bilateral reversible loss of waves I and II . Another potential source could be the induced hypothermia , but this does not seem very likely because the patient's temperature was 0.3 ° C lower at the return of the waves than at their loss .

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[ "umlsterm" ]

TRP channel is a GENE-N, TRPA-1 is a GENE-Y, TRP channel is a GENE-N, calcium is a CHEMICAL, calcium is a CHEMICAL, PKC is a GENE-N, DAF-16 is a GENE-Y, FOXO is a GENE-Y, Human TRPA1 is a GENE-Y, worm TRPA-1 is a GENE-N, TRP channels is a GENE-N, calcium is a CHEMICAL

13115_task0

Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

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A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

TRP channel is a GENE-N, TRPA-1 is a GENE-Y, TRP channel is a GENE-N, calcium is a CHEMICAL, calcium is a CHEMICAL, PKC is a GENE-N, DAF-16 is a GENE-Y, FOXO is a GENE-Y, Human TRPA1 is a GENE-Y, worm TRPA-1 is a GENE-N, TRP channels is a GENE-N, calcium is a CHEMICAL

13115_task1

Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures. Instructions: please typing these entity words according to sentence: TRP channel, TRPA-1, TRP channel, calcium, calcium, PKC, DAF-16, FOXO, Human TRPA1, worm TRPA-1, TRP channels, calcium Options: GENE-Y, GENE-N, CHEMICAL

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A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

TRP channel, TRPA-1, TRP channel, calcium, calcium, PKC, DAF-16, FOXO, Human TRPA1, worm TRPA-1, TRP channels, calcium

13115_task2

Sentence: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures. Instructions: please extract entity words from the input sentence

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A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

LASIK is an umlsterm, date is an umlsterm, complication is an umlsterm, LASIK is an umlsterm, myopia is an umlsterm

DerOpthalmologe.80950494.eng.abstr_task0

Sentence: Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia .

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[ "umlsterm" ]

LASIK is an umlsterm, date is an umlsterm, complication is an umlsterm, LASIK is an umlsterm, myopia is an umlsterm

DerOpthalmologe.80950494.eng.abstr_task1

Sentence: Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia . Instructions: please typing these entity words according to sentence: LASIK, date, complication, LASIK, myopia Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia .

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[ "umlsterm" ]

LASIK, date, complication, LASIK, myopia

DerOpthalmologe.80950494.eng.abstr_task2

Sentence: Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background : Long-term results on LASIK are not available to date . We therefore evaluated the predictability , stability and complication rate after LASIK in moderate - to-high myopia .

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[ "umlsterm" ]

phosphatidylcholine synthase is a Protein, PCS is a Protein, PCS is a Protein, Pmt is a Protein, Pcs is a Protein, Pcs is a Protein, PCS is a Protein

121_task0

Sentence: Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation.

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[ "Protein" ]

phosphatidylcholine synthase is a Protein, PCS is a Protein, PCS is a Protein, Pmt is a Protein, Pcs is a Protein, Pcs is a Protein, PCS is a Protein

121_task1

Sentence: Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation. Instructions: please typing these entity words according to sentence: phosphatidylcholine synthase, PCS, PCS, Pmt, Pcs, Pcs, PCS Options: Protein

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Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation.

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[ "Protein" ]

phosphatidylcholine synthase, PCS, PCS, Pmt, Pcs, Pcs, PCS

121_task2

Sentence: Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation. Instructions: please extract entity words from the input sentence

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Pathways for phosphatidylcholine biosynthesis in bacteria. Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes with important structural and signalling functions. Although many prokaryotes lack PC, it can be found in significant amounts in membranes of rather diverse bacteria. Two pathways for PC biosynthesis are known in bacteria, the methylation pathway and the phosphatidylcholine synthase (PCS) pathway. In the methylation pathway, phosphatidylethanolamine is methylated three times to yield PC, in reactions catalysed by one or several phospholipid N-methyltransferases (PMTs). In the PCS pathway, choline is condensed directly with CDP-diacylglyceride to form PC in a reaction catalysed by PCS. Using cell-free extracts, it was demonstrated that Sinorhizobium meliloti, Agrobacterium tumefaciens, Rhizobium leguminosarum, Bradyrhizobium japonicum, Mesorhizobium loti and Legionella pneumophila have both PMT and PCS activities. In addition, Rhodobacter sphaeroides has PMT activity and Brucella melitensis, Pseudomonas aeruginosa and Borrelia burgdorferi have PCS activities. Genes from M. loti and L. pneumophila encoding a Pmt or a Pcs activity and the genes from P. aeruginosa and Borrelia burgdorferi responsible for Pcs activity have been identified. Based on these functional assignments and on genomic data, one might predict that if bacteria contain PC as a membrane lipid, they usually possess both bacterial pathways for PC biosynthesis. However, important pathogens such as Brucella melitensis, P. aeruginosa and Borrelia burgdorferi seem to be exceptional as they possess only the PCS pathway for PC formation.

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[ "Protein" ]

complex regional pain syndrome is a Participant_Condition, motor imagery program is a Intervention_Physical, imagined movements is a Intervention_Physical, mirror movements is a Intervention_Physical, disability is a Outcome_Physical, effect is a Outcome_Other, Twenty is a Participant_Sample-size, chronic CRPS1 initiated by wrist fracture is a Participant_Condition, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . is a Intervention_Physical

20665_task0

Sentence: Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other

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Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks .

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[ "Intervention_Physical", "Participant_Condition", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size", "Outcome_Pain" ]

complex regional pain syndrome is a Participant_Condition, motor imagery program is a Intervention_Physical, imagined movements is a Intervention_Physical, mirror movements is a Intervention_Physical, disability is a Outcome_Physical, effect is a Outcome_Other, Twenty is a Participant_Sample-size, chronic CRPS1 initiated by wrist fracture is a Participant_Condition, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . is a Intervention_Physical

20665_task1

Sentence: Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks . Instructions: please typing these entity words according to sentence: complex regional pain syndrome, motor imagery program, imagined movements, mirror movements, disability, effect, Twenty, chronic CRPS1 initiated by wrist fracture, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . Options: Intervention_Physical, Participant_Condition, Outcome_Physical, Participant_Sample-size, Outcome_Other

[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks .

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[ "Intervention_Physical", "Participant_Condition", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size", "Outcome_Pain" ]

complex regional pain syndrome, motor imagery program, imagined movements, mirror movements, disability, effect, Twenty, chronic CRPS1 initiated by wrist fracture, hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) .

20665_task2

Sentence: Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Is successful rehabilitation of complex regional pain syndrome due to sustained attention to the affected limb ? A randomised clinical trial . In complex regional pain syndrome ( CRPS1 ) initiated by wrist fracture , a motor imagery program ( MIP ) , consisting of hand laterality recognition followed by imagined movements and then mirror movements , reduces pain and disability , but the mechanism of effect is unclear . Possibilities include sustained attention to the affected limb , in which case the order of MIP components would not alter the effect , and sequential activation of cortical motor networks , in which case it would . Twenty subjects with chronic CRPS1 initiated by wrist fracture and who satisfied stringent inclusion criteria , were randomly allocated to one of three groups : hand laterality recognition , imagined movements , mirror movements ( RecImMir , MIP ) ; imagined movements , recognition , imagined movements ( ImRecIm ) ; recognition , mirror movements , recognition ( RecMirRec ) . At 6 and 18 weeks , reduced pain and disability were greater for the RecImMir group than for the other groups ( P < 0.05 ) . Hand laterality recognition imparted a consistent reduction in pain and disability across groups , however , this effect was limited in magnitude . Imagined movements imparted a further reduction in pain and disability , but only if they followed hand laterality recognition . Mirror movements also imparted a reduction in pain and disability , but only when they followed imagined movements . The effect of the MIP seems to be dependent on the order of components , which suggests that it is not due to sustained attention to the affected limb , but is consistent with sequential activation of cortical motor networks .

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[ "Intervention_Physical", "Participant_Condition", "Outcome_Physical", "Outcome_Other", "Participant_Sample-size", "Outcome_Pain" ]

human phosphodiesterase is a GENE-N, cAMP is a CHEMICAL, cGMP is a CHEMICAL, PDE10A is a GENE-Y

10373451_task0

Sentence: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O" ]

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).

[ "Cloning", "and", "characterization", "of", "a", "novel", "human", "phosphodiesterase", "that", "hydrolyzes", "both", "cAMP", "and", "cGMP", "(", "PDE10A", ")", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

human phosphodiesterase is a GENE-N, cAMP is a CHEMICAL, cGMP is a CHEMICAL, PDE10A is a GENE-Y

10373451_task1

Sentence: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). Instructions: please typing these entity words according to sentence: human phosphodiesterase, cAMP, cGMP, PDE10A Options: GENE-Y, GENE-N, CHEMICAL

[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O" ]

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).

[ "Cloning", "and", "characterization", "of", "a", "novel", "human", "phosphodiesterase", "that", "hydrolyzes", "both", "cAMP", "and", "cGMP", "(", "PDE10A", ")", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

human phosphodiesterase, cAMP, cGMP, PDE10A

10373451_task2

Sentence: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "O" ]

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).

[ "Cloning", "and", "characterization", "of", "a", "novel", "human", "phosphodiesterase", "that", "hydrolyzes", "both", "cAMP", "and", "cGMP", "(", "PDE10A", ")", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose is a CHEMICAL, TNF - α is a GENE-Y

22532499_task0

Sentence: Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O" ]

Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes.

[ "Effect", "of", "water", "extracts", "from", "edible", "myrtaceae", "plants", "on", "uptake", "of", "2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose", "in", "TNF", "-", "α", "-", "treated", "FL83B", "mouse", "hepatocytes", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose is a CHEMICAL, TNF - α is a GENE-Y

22532499_task1

Sentence: Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Instructions: please typing these entity words according to sentence: 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose, TNF - α Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O" ]

Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes.

[ "Effect", "of", "water", "extracts", "from", "edible", "myrtaceae", "plants", "on", "uptake", "of", "2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose", "in", "TNF", "-", "α", "-", "treated", "FL83B", "mouse", "hepatocytes", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose, TNF - α

22532499_task2

Sentence: Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O" ]

Effect of water extracts from edible myrtaceae plants on uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose in TNF-α-treated FL83B mouse hepatocytes.

[ "Effect", "of", "water", "extracts", "from", "edible", "myrtaceae", "plants", "on", "uptake", "of", "2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose", "in", "TNF", "-", "α", "-", "treated", "FL83B", "mouse", "hepatocytes", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

psychotherapy is an umlsterm, forms is an umlsterm, treatment is an umlsterm, psychotherapy is an umlsterm, Treatment outcome is an umlsterm, sick leave is an umlsterm, medication is an umlsterm, care is an umlsterm, outpatient is an umlsterm, treatment is an umlsterm, treatment selection is an umlsterm

Psychotherapeut.90440083.eng.abstr_task0

Sentence: Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change .

[ "Short", "-", "term", "and", "long", "-", "term", "psychodynamic", "psychotherapy", "were", "the", "most", "frequent", "forms", "of", "treatment", "in", "the", "participating", "sample", "of", "therapists", ".", "Psychoanalytic", "psychotherapy", "made", "32", "%", "of", "the", "total", "of", "psychotherapeutic", "interventions", ".", "Treatment", "outcome", "shows", "substantial", "reduction", "in", "sick", "leave", ",", "psychotropic", "medication", "and", "patient", "'s", "attending", "for", "medical", "care", ".", "The", "results", "are", "discussed", "in", "terms", "of", "the", "availability", "of", "outpatient", "psychotherapeutic", "treatment", ",", "in", "terms", "of", "differential", "treatment", "selection", "and", "in", "terms", "of", "the", "validity", "of", "\"", "events", "-", "parameters", "\"", "in", "order", "to", "evaluate", "psychotherapeutic", "change", "." ]

[ "umlsterm" ]

psychotherapy is an umlsterm, forms is an umlsterm, treatment is an umlsterm, psychotherapy is an umlsterm, Treatment outcome is an umlsterm, sick leave is an umlsterm, medication is an umlsterm, care is an umlsterm, outpatient is an umlsterm, treatment is an umlsterm, treatment selection is an umlsterm

Psychotherapeut.90440083.eng.abstr_task1

Sentence: Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change . Instructions: please typing these entity words according to sentence: psychotherapy, forms, treatment, psychotherapy, Treatment outcome, sick leave, medication, care, outpatient, treatment, treatment selection Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change .

[ "Short", "-", "term", "and", "long", "-", "term", "psychodynamic", "psychotherapy", "were", "the", "most", "frequent", "forms", "of", "treatment", "in", "the", "participating", "sample", "of", "therapists", ".", "Psychoanalytic", "psychotherapy", "made", "32", "%", "of", "the", "total", "of", "psychotherapeutic", "interventions", ".", "Treatment", "outcome", "shows", "substantial", "reduction", "in", "sick", "leave", ",", "psychotropic", "medication", "and", "patient", "'s", "attending", "for", "medical", "care", ".", "The", "results", "are", "discussed", "in", "terms", "of", "the", "availability", "of", "outpatient", "psychotherapeutic", "treatment", ",", "in", "terms", "of", "differential", "treatment", "selection", "and", "in", "terms", "of", "the", "validity", "of", "\"", "events", "-", "parameters", "\"", "in", "order", "to", "evaluate", "psychotherapeutic", "change", "." ]

[ "umlsterm" ]

psychotherapy, forms, treatment, psychotherapy, Treatment outcome, sick leave, medication, care, outpatient, treatment, treatment selection

Psychotherapeut.90440083.eng.abstr_task2

Sentence: Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Short-term and long-term psychodynamic psychotherapy were the most frequent forms of treatment in the participating sample of therapists . Psychoanalytic psychotherapy made 32% of the total of psychotherapeutic interventions . Treatment outcome shows substantial reduction in sick leave , psychotropic medication and patient's attending for medical care . The results are discussed in terms of the availability of outpatient psychotherapeutic treatment , in terms of differential treatment selection and in terms of the validity of " events-parameters " in order to evaluate psychotherapeutic change .

[ "Short", "-", "term", "and", "long", "-", "term", "psychodynamic", "psychotherapy", "were", "the", "most", "frequent", "forms", "of", "treatment", "in", "the", "participating", "sample", "of", "therapists", ".", "Psychoanalytic", "psychotherapy", "made", "32", "%", "of", "the", "total", "of", "psychotherapeutic", "interventions", ".", "Treatment", "outcome", "shows", "substantial", "reduction", "in", "sick", "leave", ",", "psychotropic", "medication", "and", "patient", "'s", "attending", "for", "medical", "care", ".", "The", "results", "are", "discussed", "in", "terms", "of", "the", "availability", "of", "outpatient", "psychotherapeutic", "treatment", ",", "in", "terms", "of", "differential", "treatment", "selection", "and", "in", "terms", "of", "the", "validity", "of", "\"", "events", "-", "parameters", "\"", "in", "order", "to", "evaluate", "psychotherapeutic", "change", "." ]

[ "umlsterm" ]

transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, IgM is a PROTEINAS

443_task0

Sentence: Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: PROTEINAS

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Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica.

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[ "PROTEINAS" ]

transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, transaminasas is a PROTEINAS, GOT is a PROTEINAS, GPT is a PROTEINAS, IgM is a PROTEINAS

443_task1

Sentence: Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica. Instructions: please typing these entity words according to sentence: transaminasas, GOT, GPT, transaminasas, GOT, GPT, IgM Options: PROTEINAS

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Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica.

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[ "PROTEINAS" ]

transaminasas, GOT, GPT, transaminasas, GOT, GPT, IgM

443_task2

Sentence: Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica. Instructions: please extract entity words from the input sentence

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Paciente mujer de 13 años de edad, sin antecedentes personales de interés que consulta por edema palpebral bilateral de tres días de evolución. En la anamnesis posterior dirigida refiere cefalea acompañante con leve odinofagia, sin fiebre asociada. A la exploración física se objetiva dicho edema palpebral bilateral sin otra afectación ocular, no presenta edemas en otras localizaciones y sí hipertrofia amigdalar 2/4 sin exudados. En los días sucesivos vuelve a consultar hasta en tres ocasiones por persistencia y aumento del edema palpebral, sin aparición de otra sintomatología. Se realizan tira reactiva de orina en varias ocasiones sin detectarse proteinuria y cultivo de exudado faríngeo que resulta negativo. Ante los hallazgos clínicos y la negatividad de las pruebas realizadas hasta el momento, se solicita estudio analítico con hemograma, bioquímica sanguínea, perfil hepático y sedimento de orina con resultados normales excepto leucocitosis (18 460/µl) con predominio linfocítico (61,8%) y aumento de transaminasas (GOT 139 UI/l, GPT 184 UI/l). A los diez días del inicio del cuadro se produce resolución del edema palpebral sin haberse evidenciado a lo largo de la evolución fiebre, adenopatías ni hepatoesplenomegalia. Se realiza control analítico a las tres semanas encontrando un hemograma sin alteraciones y descenso de las transaminasas hasta valores normales (GOT 22 UI/l, GPT 16 UI/l). Ante la sospecha de síndrome mononucleósico se solicita serología de VEB y citomegalovirus (CMV), obteniéndose IgM positiva frente a VEB lo que permite la confirmación diagnóstica.

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[ "PROTEINAS" ]

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DerHautarzt.70480175.eng.abstr_task0

Sentence: A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes .

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[ "umlsterm" ]

polymerase chain reaction is an umlsterm, PCR is an umlsterm, assay is an umlsterm, dermatophytes is an umlsterm, gene is an umlsterm, rRNA is an umlsterm, fungi is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, yeasts is an umlsterm, oligonucleotides is an umlsterm, identification is an umlsterm, dermatophytes is an umlsterm, Candida albicans is an umlsterm, analysis is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, yeasts is an umlsterm, PCR is an umlsterm, fungi is an umlsterm, human is an umlsterm, DNA is an umlsterm, dermis is an umlsterm, epidermis is an umlsterm, DNA is an umlsterm, plants is an umlsterm, animals is an umlsterm, PCR is an umlsterm, assay is an umlsterm, skin is an umlsterm, nail is an umlsterm, PCR is an umlsterm, culture is an umlsterm, PCR is an umlsterm, dermatophytes is an umlsterm, culture is an umlsterm, Sensitivity is an umlsterm, PCR is an umlsterm, culture is an umlsterm, PCR is an umlsterm, culture is an umlsterm, dermatophytes is an umlsterm

DerHautarzt.70480175.eng.abstr_task1

Sentence: A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes . Instructions: please typing these entity words according to sentence: polymerase chain reaction, PCR, assay, dermatophytes, gene, rRNA, fungi, PCR, dermatophytes, yeasts, oligonucleotides, identification, dermatophytes, Candida albicans, analysis, PCR, dermatophytes, yeasts, PCR, fungi, human, DNA, dermis, epidermis, DNA, plants, animals, PCR, assay, skin, nail, PCR, culture, PCR, dermatophytes, culture, Sensitivity, PCR, culture, PCR, culture, dermatophytes Options: umlsterm

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A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes .

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[ "umlsterm" ]

polymerase chain reaction, PCR, assay, dermatophytes, gene, rRNA, fungi, PCR, dermatophytes, yeasts, oligonucleotides, identification, dermatophytes, Candida albicans, analysis, PCR, dermatophytes, yeasts, PCR, fungi, human, DNA, dermis, epidermis, DNA, plants, animals, PCR, assay, skin, nail, PCR, culture, PCR, dermatophytes, culture, Sensitivity, PCR, culture, PCR, culture, dermatophytes

DerHautarzt.70480175.eng.abstr_task2

Sentence: A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers " TR1" and " TR2" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes .

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[ "umlsterm" ]

GTP is a compound, ras is a protein, Rheb is a protein

DS.d1001_task0

Sentence: The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O" ]

The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.

[ "The", "dominant", "positive", "regulator", "of", "mTORC1", "is", "the", "GTP", "-", "charged", "form", "of", "the", "ras", "-", "like", "GTPase", "Rheb", "." ]

[ "protein", "compound" ]

GTP is a compound, ras is a protein, Rheb is a protein

DS.d1001_task1

Sentence: The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb. Instructions: please typing these entity words according to sentence: GTP, ras, Rheb Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O" ]

The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.

[ "The", "dominant", "positive", "regulator", "of", "mTORC1", "is", "the", "GTP", "-", "charged", "form", "of", "the", "ras", "-", "like", "GTPase", "Rheb", "." ]

[ "protein", "compound" ]

GTP, ras, Rheb

DS.d1001_task2

Sentence: The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein", "O" ]

The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb.

[ "The", "dominant", "positive", "regulator", "of", "mTORC1", "is", "the", "GTP", "-", "charged", "form", "of", "the", "ras", "-", "like", "GTPase", "Rheb", "." ]

[ "protein", "compound" ]

progesterone is a compound, 17beta - estradiol is a compound, gonadotropin - releasing hormone is a protein

DS.d1245_task0

Sentence: The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.

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[ "protein", "compound" ]

progesterone is a compound, 17beta - estradiol is a compound, gonadotropin - releasing hormone is a protein

DS.d1245_task1

Sentence: The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast. Instructions: please typing these entity words according to sentence: progesterone, 17beta - estradiol, gonadotropin - releasing hormone Options: compound, protein

[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.

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[ "protein", "compound" ]

progesterone, 17beta - estradiol, gonadotropin - releasing hormone

DS.d1245_task2

Sentence: The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may directly signal the growth and development of the embryoblast.

[ "The", "secretion", "of", "endorphins", ",", "progesterone", "(", "P(4", ")", ")", ",", "human", "chorionic", "gonadotropin", ",", "17beta", "-", "estradiol", ",", "and", "gonadotropin", "-", "releasing", "hormone", "by", "trophoblasts", "that", "lie", "adjacent", "to", "the", "embryoblast", "in", "the", "blastocyst", "suggests", "that", "these", "pregnancy", "-", "associated", "factors", "may", "directly", "signal", "the", "growth", "and", "development", "of", "the", "embryoblast", "." ]

[ "protein", "compound" ]

Patienten is an umlsterm, Stenose is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Herzbeutel - Tamponade is an umlsterm, Blutdruckabfall is an umlsterm, Schmerzsymptomatik is an umlsterm, Herzbeuteltamponade is an umlsterm, Perikarderguss is an umlsterm, Blut is an umlsterm, Kontrollangiographie is an umlsterm, Venen - Bypass is an umlsterm, Patient is an umlsterm

ZfuerKardiologie.80870233.ger.abstr_task0

Sentence: Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden .

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[ "umlsterm" ]

Patienten is an umlsterm, Stenose is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Stenose is an umlsterm, Stent is an umlsterm, Herzbeutel - Tamponade is an umlsterm, Blutdruckabfall is an umlsterm, Schmerzsymptomatik is an umlsterm, Herzbeuteltamponade is an umlsterm, Perikarderguss is an umlsterm, Blut is an umlsterm, Kontrollangiographie is an umlsterm, Venen - Bypass is an umlsterm, Patient is an umlsterm

ZfuerKardiologie.80870233.ger.abstr_task1

Sentence: Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden . Instructions: please typing these entity words according to sentence: Patienten, Stenose, Stenose, Stent, Stenose, Stent, Herzbeutel - Tamponade, Blutdruckabfall, Schmerzsymptomatik, Herzbeuteltamponade, Perikarderguss, Blut, Kontrollangiographie, Venen - Bypass, Patient Options: umlsterm

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Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden .

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[ "umlsterm" ]

Patienten, Stenose, Stenose, Stent, Stenose, Stent, Herzbeutel - Tamponade, Blutdruckabfall, Schmerzsymptomatik, Herzbeuteltamponade, Perikarderguss, Blut, Kontrollangiographie, Venen - Bypass, Patient

ZfuerKardiologie.80870233.ger.abstr_task2

Sentence: Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden . Instructions: please extract entity words from the input sentence

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Bei einem 70jaehrigen Patienten mit koronarer Dreigefaesserkrankung und Zustand nach ACB-Operation 1989 zeigte die diagnostische Kerzkatheteruntersuchung eine filiforme Ostiumstenose des Lambda-Bypasses ( R. circumflexus und R. marginalis ) sowie eine filiforme Stenose des RIVA-Bypasses unmittelbar vor der peripheren Anastomose . Der ACD-Bypass war verschlossen . Waehrend die Stenose des Lambda-Bypasses problemlos mit gutem Primaerresultat mit einem Stent versorgt werden kann , kommt es beim Versuch , die filiforme Stenose des RIVA-ACB zu dilatieren bzw. einen Stent zu implantieren , zu der seltenen vital bedrohlichen Bypass-Perforation mit einer sich rasch entwickelnden Herzbeutel-Tamponade . Wegen sofortigem Blutdruckabfall mit schwerster Schmerzsymptomatik wird sofort ein Autoperfusionskatheter im Bereich der Perforationsstelle positioniert , worauf sich die haemodynamische Situation stabilisiert . Ein Abdichten durch mehrfaches Aufblasen und Ablassen des Perfusionsballons war nicht moeglich , so dass dieser entfaltet im Gefaess belassen wird . Dennoch kommt es im weiteren Verlauf zu einer Herzbeuteltamponade . Der abgekapselte Perikarderguss wird an atypischer Stelle ( intercostal ) erfolgreich punktiert . Ueber einen Perikard-Pigtail-Katheter werden in der naechsten Stunde ca. sieben Liter Blut entnommen und retransfundiert . Da der kardiologisch interventionelle Weg zwar die Situation stabilisiert , das Problem des Abdichtens der Perforationsstelle jedoch nicht loesen kann , faellt die Entscheidung zur Operation . Mittels linksthorakaler Thoraktomie werden saemtliche Blutkoagel ausgeraeumt , trotz sorgfaeltigster Inspektion kann jedoch keine Blutungsquelle ausfindig gemacht werden . Somit muss von einem Spontanverschluss der Perforationsstelle durch Thrombusbildung ausgegangen werden . Eine Kontrollangiographie eine Woche spaeter zeigte ein gutes Resultat sowohl am Lambda-Bypass als auch am Venen-Bypass auf den RIVA ohne Extravasat oder Nachweis der ehemaligen Perforationsstelle . Der Patient konnte in beschwerdefreiem Zustand nach Hause entlassen werden .

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[ "umlsterm" ]

Notfallbehandlung is an umlsterm, Thoraxschmerzes is an umlsterm, Patienten is an umlsterm, Myokardinfarkt is an umlsterm, Koronarsyndrom is an umlsterm, Behandlung is an umlsterm, Akutdiagnostik is an umlsterm, Zeit is an umlsterm, Rolle is an umlsterm, Ischaemietoleranz is an umlsterm, Myokards is an umlsterm, Zeit is an umlsterm, Infarktgefaesses is an umlsterm, Infarktstunde is an umlsterm, Patienten is an umlsterm, Herzrhythmusstoerungen is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm

IntensiveMedizin.90360727.ger.abstr_task0

Sentence: Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik .

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[ "umlsterm" ]

Notfallbehandlung is an umlsterm, Thoraxschmerzes is an umlsterm, Patienten is an umlsterm, Myokardinfarkt is an umlsterm, Koronarsyndrom is an umlsterm, Behandlung is an umlsterm, Akutdiagnostik is an umlsterm, Zeit is an umlsterm, Rolle is an umlsterm, Ischaemietoleranz is an umlsterm, Myokards is an umlsterm, Zeit is an umlsterm, Infarktgefaesses is an umlsterm, Infarktstunde is an umlsterm, Patienten is an umlsterm, Herzrhythmusstoerungen is an umlsterm, Diagnostik is an umlsterm, Therapie is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm

IntensiveMedizin.90360727.ger.abstr_task1

Sentence: Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik . Instructions: please typing these entity words according to sentence: Notfallbehandlung, Thoraxschmerzes, Patienten, Myokardinfarkt, Koronarsyndrom, Behandlung, Akutdiagnostik, Zeit, Rolle, Ischaemietoleranz, Myokards, Zeit, Infarktgefaesses, Infarktstunde, Patienten, Herzrhythmusstoerungen, Diagnostik, Therapie, Therapie, Patienten Options: umlsterm

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Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik .

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[ "umlsterm" ]

Notfallbehandlung, Thoraxschmerzes, Patienten, Myokardinfarkt, Koronarsyndrom, Behandlung, Akutdiagnostik, Zeit, Rolle, Ischaemietoleranz, Myokards, Zeit, Infarktgefaesses, Infarktstunde, Patienten, Herzrhythmusstoerungen, Diagnostik, Therapie, Therapie, Patienten

IntensiveMedizin.90360727.ger.abstr_task2

Sentence: Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik . Instructions: please extract entity words from the input sentence

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Die praeklinische Notfallbehandlung des akuten Thoraxschmerzes zaehlt zu den haeufigsten Einsaetzen des Notarztes , wobei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt . Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese , der klinischen Symptomatik , der moeglichen Akutdiagnostik und den therapeutischen Optionen . Dabei spielt der Faktor Zeit die entscheidenden Rolle ! Aufgrund der geringen Ischaemietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereroeffnung des Infarktgefaesses einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikulaere Herzrhythmusstoerungen . In der vorliegenden Uebersicht wird auf die akute praeklinische Diagnostik und moegliche Therapie ausfuehrlich eingegangen , mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie , der sicheren Ueberwachung und des sicheren Transportes des Patienten in die Klinik .

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