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Enelpol 10

What is the purpose of Macropinocytosis?

Macropinocytosis is an endocytic process, which involves the engulfment of extra-cellular content in vesicles known as macropinosomes.

4573

Which are the main histone modifications associated with enhancers?

Histone 3 lysine 4 mono- (H3K4me1) and di-methylation (H3K4me2) are the main post-transcriptional histone modifications related to enhancer activity.

1578

Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection?

Preimplantation Genetic Diagnosis can be used for gender selection.

1585

List diseases that are repeat expansion disorders (REDs).

The expansion of Short tandem repeats underlies the pathogenesis of multiple neurological disorders, including Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal dementia, fragile X-associated tremor/ataxia syndrome, and myotonic dystrophies, known as repeat expansion disorders (REDs).

4596

List biomarkers for sepsis.

HCK, PRKCD, SIRPA, DOK3, ITGAM, LTB4R, MAPK14, MALT1, NLRC3, LCK C-Reactive Protein (CRP), Procalcitonin (PCT) and Interleukin 6 (IL-6) sTM

4474

What is the use of MammaPrint and Oncotype DX?

The MammaPrint and Oncotype DX assays are used to predict breast cancer recurrence risk and guide adjuvant chemotherapy decisions.

1518

Which is the process that Conserved noncoding elements mostly regulate?

Conserved noncoding elements play a fundamental role in regulating animal development

1678

How is transcriptional elongation affected by nucleosome positioning?

In order to elongate their products, both DNA and RNA polymerases must be able to overcome the inhibition presented by chromatin. Nucleosome arrays inhibit both initiation and elongation of transcripts.

3477

Which miRNA is targeted by SRY/Sox9?

The testis-specific circRNA, sex-determining region Y (Sry), serves as a miR-138 sponge, suggesting that miRNA sponge effects achieved by circRNA formation are a general phenomenon

2099

Where is the protein Bouncer located?

Bouncer is membrane bound.

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Do chromatin features predict genes associated with eQTLs?

Yes, genomic proximity plus five TF and chromatin features are able to predict>90% of target genes within 1 megabase of eQTLs

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Are stretch enhancers transcribed more than super-enhancers?

No. Super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers.

3503

Are there any urine biomarkers for bladder cancer diagnosis?

Bladder cancer is any of several types of malignancy arising from the epithelial lining of the urinary bladder. Rarely the bladder is involved by non-epithelial cancers, such as lymphoma or sarcoma. It is a disease in which abnormal cells multiply without control in the bladder.The bladder is a hollow, muscular organ that stores urine; it is located in the pelvis. The most common type of bladder cancer recapitulates the normal histology of the urothelium and is known as transitional cell carcinoma or more properly urothelial cell carcinoma. It is estimated that there are 383,000 cases of bladder cancer worldwide

677

What is Mendelian randomization?

Instrumental variable analysis is an approach for obtaining causal inferences on the effect of an exposure (risk factor) on an outcome from observational data. It has gained in popularity over the past decade with the use of genetic variants as instrumental variables, known as Mendelian randomization.

2742

What is amphiregulin a ligand of?

Amphiregulin (AREG) is an epidermal growth factor receptor (EGFR) ligand.

4648

What is protein carbamylation?

Protein carbamylation is a post-translational modification that can occur in the presence of urea. In solution, urea is in equilibrium with ammonium cyanate, and carbamylation occurs when cyanate ions react with the amino groups of lysines, arginines, protein N-termini, as well as sulfhydryl groups of cysteines. Protein carbamylation is one of the important post-translational modifications, which plays a pivotal role in a number of biological conditions, such as diseases, chronic renal failure and atherosclerosis.

631

Is DNA methylation an epigenetic modification of chromatin related to gene expression?

Epigenetic changes such as DNA methylation alter gene expression at the level of transcription by upregulating, downregulating, or silencing genes completely.

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