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111800
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111801
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111803
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111805
[ "Increased", "mean", "platelet", "volume", "(", "MPV", ")", ",", "a", "sensitive", "indicator", "of", "circulating", "platelet", "activity", "and", "a", "prognostic", "marker", "in", "thromboinflammation", "[", "37–39", "]", ",", "has", "also", "been", "reported", "in", "association", "with", "specific", "viral", "infections", "[", "40", "]", "." ]
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111806
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111807
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111809
[ "The", "receiver", "operating", "characteristic", "(", "ROC", ")", "curve", "demonstrates", "a", "tradeoff", "between", "sensitivity", "and", "specificity", "(", "Figure", "5", ")", "." ]
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111811
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111812
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111813
[ "Epithelial", "-", "to", "-", "mesenchymal", "transition", "(", "EMT", ")", "is", "a", "reversible", "process", "in", "which", "cancer", "cells", "loss", "their", "epithelial", "features", "and", "transform", "into", "mesenchymal", "cells", ",", "and", "is", "a", "crucial", "step", "in", "the", "acquisition", "of", "metastatic", "behavior", "of", "tumors", "[", "33", "]", "." ]
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111814
[ "For", "example", ",", "Mediator", "facilitates", "the", "transcription", "of", "four", "key", "transcription", "factors", "(", "TFs", ")", "that", "reprogram", "somatic", "cells", "to", "embryonic", "stem", "cells", "(", "ESC", ")", "through", "SEs", ",", "whereas", "the", "reduced", "levels", "of", "Mediator", "induce", "ESC", "differentiation", "by", "blunting", "the", "activity", "of", "these", "TFs", "[", "8", ",", "12", "]", "." ]
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111815
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111816
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111817
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111818
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111819
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111820
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111823
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111824
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111825
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111826
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111827
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111828
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111829
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111830
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111831
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111832
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111833
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111834
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111835
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111836
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111837
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111838
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111839
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111840
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111841
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111842
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111843
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111844
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111847
[ "The", "ability", "of", "cannabis", "consumption", "to", "induce", "psychotomimetic", "symptoms", "has", "long", "been", "recognized", "[", "5", "]", "and", "attributed", "to", "its", "psychoactive", "ingredient", ",", "Δ9", "-", "tetrahydrocannabinol", "(", "THC", ")", ".", "The", "commonly", "accepted", "view", "is", "that", "cannabis", "exposure", ",", "as", "in", "the", "case", "of", "other", "drugs", "of", "abuse", "[", "8", "]", ",", "has", "a", "negative", "impact", "on", "the", "disease", "outcome", "[", "5", "]", "leading", "to", ":", "worsening", "of", "psychotic", "symptoms", "[", "9,10", "]", ",", "relapse", "[", "11,12", "]", ",", "and", "decreased", "global", "functioning", "over", "time", "(", "[", "10", "]", ",", "but", "see", "[", "13", "]", ")", "." ]
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111848
[ "To", "determine", "whether", "Hh", "regulates", "the", "production", "of", "PI(4)P", "in", "vertebrate", "systems", ",", "using", "the", "ELISA", "assay", "combined", "with", "the", "anti", "-", "PI(4)P", "antibody", ",", "we", "examined", "the", "levels", "of", "PI(4)P", "in", "ptc1", "mutant", "mouse", "embryonic", "fibroblasts", "(", "MEFs", ")", "and", "found", "that", ",", "compared", "to", "control", "MEFs", ",", "ptc1", "MEFs", "had", "significantly", "increased", "PI(4)P", "(", "Fig", "7F", ")", ".", "Consistently", ",", "Shh", "treatment", "increased", ",", "whereas", "Smo", "inhibitor", "decreased", ",", "the", "levels", "of", "PI(4)P", "(", "S7A", "Fig", ")", ",", "indicating", "that", "Hh", "signaling", "activity", "promotes", "PI(4)P", "production", "in", "cultured", "cells", "." ]
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111849
[ "Necrosis", "amplifies", "inflammation", "and", "plays", "important", "roles", "in", "acute", "respiratory", "distress", "syndrome", "(", "ARDS", ")", ".", "Necroptosis", "is", "a", "newly", "identified", "programmed", "necrosis", "that", "is", "mediated", "by", "receptor", "interacting", "protein", "3", "(", "RIP3", ")", "." ]
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111850
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111851
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111852
[ "LYM", ",", "lymphopenia", ";", "CRP", ",", "C", "-", "reactive", "protein", ";", "LDH", ",", "lactate", "dehydrogenase", ";", "AUC", ",", "area", "under", "the", "curve", ";", "ROC", ",", "receiver", "-", "operator", "curve", "." ]
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111854
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111855
[ "It", "has", "been", "reported", "that", "5-ASA", "undergoes", "extensive", "inactivation", "to", "N", "-", "acetyl", "-", "ASA", "via", "N", "-", "acetyltransferase-1", "(", "NAT-1", ")", "in", "the", "colonic", "mucosa", "and", "liver", ",", "which", "may", "be", "the", "underlying", "mechanism", "leading", "to", "low", "drug", "availability", "(", "20–30", "%", ")", "[", "48,49", "]", "." ]
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111856
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111857
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111858
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111860
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111861
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111894
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