Datasets:

surrey-nlp

/

PLOD-filtered

like 0

[ "Expression", "of", "integrin", "αIIbβ3", ",", "also", "named", "glycoprotein", "(", "GP", ")", "IIb", "/", "IIIa", "receptor", "complex", ",", "is", "restricted", "to", "the", "megakaryocyte", "lineage", ",", "being", "the", "most", "abundant", "PLT", "receptor", "[", "8", "]", "." ]

[ 8, 1, 8, 8, 13, 2, 16, 8, 13, 12, 13, 8, 15, 8, 8, 8, 13, 3, 16, 1, 6, 8, 8, 13, 3, 6, 2, 0, 12, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]

[ "Additionally", ",", "simple", "sequence", "repeat", "(", "SSR", ")", "loci", "were", "detected", "using", "MISA", "(", "https://webblast.ipk-gatersleben.de/misa/", ")", "[", "33", "]", "with", "the", "following", "settings", ":", "10", "repeats", "for", "mono", "-", "types", ",", "five", "repeats", "for", "di", "-", "types", ",", "four", "repeats", "for", "tri-", ",", "and", "three", "repeats", "for", "tetra-", ",", "penta-", "and", "hexa", "-", "types", ",", "respectively", "." ]

[ 2, 13, 0, 8, 8, 13, 12, 13, 8, 3, 16, 16, 12, 13, 17, 13, 17, 17, 17, 1, 6, 0, 8, 13, 9, 8, 1, 0, 13, 8, 13, 9, 8, 1, 0, 13, 8, 13, 9, 8, 1, 0, 13, 5, 9, 8, 1, 0, 13, 0, 5, 8, 13, 8, 13, 2, 13 ]

[ 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "then", "further", "assessed", "potential", "population", "stratification", "of", "each", "SNP", "by", "testing", "its", "association", "with", "self", "-", "declared", "ethnicity", "in", "the", "CaMos", "cohort", "and", "tested", "the", "association", "of", "each", "SNP", "with", "non", "-", "European", "status", ",", "defined", "as", "exclusion", "from", "the", "European", "cluster", "in", "principal", "component", "analysis", "(", "PCA", ")", "." ]

[ 11, 2, 2, 16, 0, 8, 8, 1, 6, 12, 1, 16, 11, 8, 1, 8, 0, 16, 8, 1, 6, 12, 8, 5, 16, 6, 8, 1, 6, 12, 1, 0, 0, 0, 8, 13, 16, 1, 8, 1, 6, 0, 8, 1, 0, 8, 8, 13, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0 ]

[ "Silent", "synapses", "mature", "(", "unsilence", ")", "by", "long", "-", "term", "synaptic", "potentiation", "(", "LTP)-driven", "incorporation", "of", "AMPARs", "[", "35–38", "]", "." ]

[ 0, 8, 16, 13, 8, 13, 1, 0, 13, 8, 0, 8, 13, 12, 8, 1, 12, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 1, 0, 0, 0, 0 ]

[ "The", "mean", "relative", "abundance", "or", "average", "detection", "(", "presence", "/", "absence", ")", "is", "presented", "for", "cases", "and", "controls", ",", "and", "the", "p", "value", "from", "a", "Wald", "test", "adjusting", "for", "age", ",", "sex", "and", "body", "mass", "index", "(", "BMI", ")", "is", "provided", "." ]

[ 6, 0, 0, 8, 5, 0, 8, 13, 8, 15, 8, 13, 3, 16, 1, 8, 5, 8, 13, 5, 6, 8, 8, 1, 6, 12, 8, 16, 1, 8, 13, 8, 5, 8, 8, 8, 13, 12, 13, 3, 16, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0 ]

[ "Poly(A", ")", "polymerase", "(", "PAP", ")", "is", "recruited", "to", "the", "complex", "during", "the", "cleavage", "reaction", "and", "initiates", "polymerization", "of", "the", "adenosine", "tract", "in", "a", "biphasic", "manner", ";", "initial", "slow", "distributive", "adenosine", "addition", "proceeds", "until", "a", "sufficiently", "long", "tail", "has", "been", "formed", "to", "allow", "binding", "of", "nuclear", "poly(A", ")", "binding", "protein", "(", "PABPN", ")", ",", "then", "rapid", "polymerization", "of", "the", "remaining", "200–250", "nucleotides", "(", "nt", ")", "ensues", ",", "whereupon", "PAP", "reverts", "to", "a", "distributive", "mode", "and", "dissociates", "from", "the", "transcript", "[", "16", "]", "." ]

[ 8, 13, 8, 13, 12, 13, 3, 16, 1, 6, 8, 1, 6, 8, 8, 5, 16, 8, 1, 6, 8, 8, 1, 6, 0, 8, 13, 0, 0, 0, 8, 8, 16, 14, 6, 2, 0, 8, 3, 3, 16, 1, 16, 16, 1, 0, 8, 13, 16, 8, 13, 12, 13, 13, 2, 0, 8, 1, 6, 16, 9, 8, 13, 12, 13, 16, 13, 14, 12, 16, 1, 6, 0, 8, 5, 16, 1, 6, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Factors", "not", "significantly", "associated", "with", "renal", "involvement", "were", ":", "blood", "pressure", ";", "orchitis", ";", "elevated", "C", "-", "reactive", "protein", ";", "elevated", "erythrocyte", "sedimentation", "rate", "(", "ESR", ")", ";", "and", "elevated", "serum", "IgA", "/", "IgE", "or", "IgG." ]

[ 8, 10, 2, 16, 1, 0, 8, 3, 13, 8, 8, 13, 8, 13, 0, 8, 13, 0, 8, 13, 0, 8, 8, 8, 13, 12, 13, 13, 5, 0, 0, 8, 15, 8, 5, 8 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "correspondence", "analysis", "(", "CA", ")", "of", "the", "survey", "data", "(", "including", "intestinal", "parasite", "load", ")", "also", "revealed", "lifestyle", "differences", "between", "these", "populations", "(", "Fig", "2A", ")", ".", "The", "first", "CA", "dimension", "(", "CA1", ")", "explained", "15.8", "%", "variation", "in", "the", "data", "and", "was", "strongly", "correlated", "with", "lifestyle", "gradients", "." ]

[ 6, 8, 8, 13, 12, 13, 1, 6, 8, 8, 13, 16, 0, 8, 8, 13, 2, 16, 8, 8, 1, 6, 8, 13, 12, 9, 13, 13, 6, 0, 12, 8, 13, 8, 13, 16, 9, 8, 8, 1, 6, 8, 5, 3, 2, 16, 1, 8, 8, 13 ]

[ 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "input", "of", "ATP", "energy", "occurs", "in", "two", "dedicated", "nucleotide", "-", "binding", "domains", "(", "NBDs", ")", ",", "whose", "configuration", "in", "intact", "transporters", "is", "controversial", "." ]

[ 6, 8, 1, 12, 8, 16, 1, 9, 0, 8, 13, 16, 8, 13, 12, 13, 13, 6, 8, 1, 0, 8, 3, 0, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "On", "the", "other", "hand", ",", "increased", "levels", "of", "expression", "of", "two", "inhibitors", "for", "Wnt", "signaling", ",", "secreted", "frizzled", "related", "protein", "(", "SFRP", ")", "5", "and", "Naked1", ",", "were", "among", "the", "most", "significantly", "increased", "in", "expression", "in", "high", "gainers", "(", "Table", "1", ")", "." ]

[ 1, 6, 0, 8, 13, 16, 8, 1, 8, 1, 9, 8, 1, 8, 8, 13, 16, 16, 0, 8, 13, 12, 13, 9, 5, 12, 13, 3, 1, 6, 2, 2, 16, 1, 8, 1, 0, 8, 13, 12, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Two", "-", "dimensional", "STED", "images", "of", "fixed", "HT-1080", "cells", "show", "that", "calnexin", "and", "derlin-1", "puncta", "show", "minimal", "overlap", "and", "that", "many", "of", "these", "ER", "protein", "puncta", "align", "along", "ERmoxGFP", "-", "labeled", "tubules", "(", "Fig", "4D", ")", ".", "Three", "-", "dimensional", "(", "3D", ")", "STED", "analysis", "shows", "that", "the", "majority", "of", "calnexin", "and", "derlin-1", "puncta", "are", "intercalated", "into", "the", "ERmoxGFP", "tubular", "network", "and", "that", "these", "two", "ER", "-", "resident", "proteins", "show", "minimal", "overlap", "(", "Fig", "4E", ";", "S2", "Video", ")", ",", "highlighting", "the", "nanodomain", "heterogeneity", "of", "peripheral", "ER", "tubules", "." ]

[ 9, 13, 0, 12, 8, 1, 16, 12, 8, 16, 14, 8, 5, 8, 8, 16, 0, 8, 5, 14, 0, 1, 6, 12, 8, 8, 16, 1, 12, 13, 16, 8, 13, 8, 9, 13, 13, 9, 13, 0, 13, 12, 13, 12, 8, 16, 14, 6, 8, 1, 8, 5, 8, 8, 3, 16, 1, 6, 12, 0, 8, 5, 14, 6, 9, 12, 13, 0, 8, 16, 0, 8, 13, 8, 9, 13, 12, 12, 13, 13, 16, 6, 8, 8, 1, 0, 12, 8, 13 ]

[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0 ]

[ "The", "expression", "of", "insulin", "-", "like", "growth", "factor", "2", "is", "significant", "higher", "in", "gestational", "diabetes", "mellitus", "group", "(", "GDM", "group", ")", "compared", "to", "normal", "glucose", "tolerance", "group", "(", "NGT", "group", ")", "both", "in", "umbilical", "cord", "blood", "and", "placenta", ",", "while", "the", "expression", "of", "H19", "is", "significant", "lower", "in", "GDM", "group", "in", "umbilical", "cord", "blood", "." ]

[ 6, 8, 1, 8, 13, 0, 8, 8, 9, 3, 0, 0, 1, 0, 8, 8, 8, 13, 12, 8, 13, 16, 1, 0, 8, 8, 8, 13, 12, 8, 13, 11, 1, 0, 8, 8, 5, 8, 13, 14, 6, 8, 1, 8, 3, 0, 0, 1, 12, 8, 1, 0, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "Healthcare", "reforms", "(", "HR", ")", "initiated", "by", "many", "countries", "impacts", "on", "healthcare", "systems", "worldwide", "." ]

[ 8, 8, 13, 12, 13, 16, 1, 0, 8, 8, 1, 8, 8, 2, 13 ]

[ 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "There", "are", "essentially", "indistinguishable", "phase", "delays", "18", "h", "after", "the", "last", "DL", "(", "dark", "-", "light", ")", "transition", "for", "perL", "flies", "and", "15", "h", "after", "the", "last", "DL", "transition", "for", "wild", "-", "type", "flies", "." ]

[ 11, 16, 2, 0, 8, 8, 9, 8, 1, 6, 0, 12, 13, 0, 13, 8, 13, 8, 1, 8, 8, 5, 9, 8, 1, 6, 0, 12, 8, 1, 0, 13, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]

[ "Mean", "fluorescence", "intensity", "(", "MFI", ")", "value", "±", "SEM", "of", "IL-1β", "expression", "for", "each", "stimulation", "conditions", "(", "CTRL", ":", "open", "bars", ",", "LPS", ":", "grey", "bars", ",", "LPS+ATP", ":", "black", "bars", ")", "after", "4", ",", "8", "and", "24h", "in", "(", "A", ")", "CD14", "+", "monocytes", ",", "(", "B", ")", "CD15+CD16", "+", "neutrophils", ".", "n", "=", "6", ".", "*", "p<0.05", "and", "*", "*", "p<0.008", "analyzed", "by", "mixed", "effects", "analysis", "with", "Tukey", "’s", "multiple", "comparison", "test", "." ]

[ 8, 8, 8, 13, 12, 13, 8, 15, 12, 1, 12, 8, 1, 6, 8, 8, 13, 8, 13, 0, 8, 13, 12, 13, 0, 8, 13, 12, 13, 0, 8, 13, 1, 9, 13, 9, 5, 9, 1, 13, 8, 13, 8, 8, 8, 13, 13, 8, 13, 8, 8, 8, 13, 8, 15, 9, 13, 8, 9, 5, 8, 8, 9, 16, 1, 16, 8, 8, 1, 12, 10, 0, 8, 8, 13 ]

[ 3, 4, 4, 0, 1, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Values", "are", "Mean", "±", "SD", "or", "%", ".", "hsCRP", ":", "EATV", ":", "epicardial", "adipose", "tissue", "volume", ";", "hsCRP", ":", "high", "sensitive", "C", "-", "reactive", "protein", "." ]

[ 8, 3, 8, 0, 8, 5, 8, 13, 12, 13, 12, 13, 0, 0, 8, 8, 13, 12, 13, 0, 0, 8, 13, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 4, 4, 4, 4, 0 ]

[ "PRTCTR", ":", "preterm", "gestational", "control", ",", "n", "=", "6", ";", "PRT+IL", ":", "preterm", "with", "Intralipids", ",", "n", "=", "5", ";", "PRT", "-IL", ":", "preterm", "without", "Intralipids", ",", "n", "=", "8", ";", "TERMCTR", ":", "term", "gestational", "control", ",", "n", "=", "6", ";", "TERM+14d", ":", "term", "gestational", "control", "surviving", "14", "days", ",", "n", "=", "3", "." ]

[ 12, 13, 8, 0, 8, 13, 8, 13, 9, 13, 12, 13, 8, 1, 8, 13, 8, 13, 9, 13, 12, 12, 13, 8, 1, 8, 13, 8, 13, 9, 13, 12, 13, 8, 0, 8, 13, 8, 13, 9, 13, 12, 13, 8, 0, 8, 16, 9, 8, 13, 8, 13, 9, 13 ]

[ 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 3, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 3, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "PDGFRα+", "cells", "directly", "interact", "with", "interstitial", "cells", "of", "Cajal", "(", "ICC", ")", "and", "smooth", "muscle", "cells", "(", "SMC", ")", "in", "gastrointestinal", "smooth", "muscle", "tissue", "." ]

[ 12, 8, 2, 16, 1, 0, 8, 1, 12, 13, 12, 13, 5, 0, 8, 8, 13, 12, 13, 1, 0, 0, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "methodological", "quality", "of", "the", "case", "-", "control", "and", "cohort", "studies", "was", "evaluated", "using", "the", "Newcastle", "and", "Ottawa", "Scale", "(", "NOS", ")", "[", "18", "]", ",", "and", "the", "quality", "of", "the", "systematic", "reviews", "and", "meta", "-", "analyses", "was", "assessed", "by", "using", "the", "Assessment", "of", "Multiple", "Systematic", "Reviews", "(", "AMSTAR", ")", "scale", "[", "19", "]", "." ]

[ 6, 0, 8, 1, 6, 8, 8, 8, 5, 8, 8, 3, 16, 16, 6, 12, 5, 12, 12, 13, 12, 13, 13, 9, 13, 13, 5, 6, 8, 1, 6, 0, 8, 5, 8, 8, 8, 3, 16, 1, 16, 6, 12, 1, 12, 12, 12, 13, 12, 13, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "An", "independent", "data", "and", "safety", "monitoring", "board", "(", "DSMB", ")", "was", "appointed", "before", "the", "study", "began", "to", "review", "both", "the", "safety", "data", "reports", "as", "the", "trial", "progressed", "and", "the", "data", "analysis", "by", "Statistics", "Collaborative", "after", "study", "completion", "." ]

[ 6, 0, 8, 5, 8, 8, 8, 13, 12, 13, 3, 16, 14, 6, 8, 16, 10, 16, 5, 6, 8, 8, 8, 14, 6, 8, 16, 5, 6, 8, 8, 1, 12, 12, 1, 8, 8, 13 ]

[ 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "95", "%", "confidence", "intervals", "(", "CIs", ")", "for", "each", "study", "are", "estimated", "using", "the", "Clopper", "-", "Pearson", "method", "[", "15", "]", "." ]

[ 6, 9, 8, 8, 8, 13, 12, 13, 1, 6, 8, 3, 16, 16, 6, 12, 13, 12, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Note", ":", "R", ",", "right", ";", "L", ",", "left", ";", "B", ",", "bilateral", ";", "DLPFC", "=", "Dorsolateral", "prefrontal", "cortex", ";", "IPL", "=", "Inferior", "Parietal", "Lobule;ACC", "=", "Anterior", "Cingulate", "Cortex", "." ]

[ 16, 13, 8, 13, 2, 13, 8, 13, 2, 13, 8, 13, 0, 13, 12, 13, 0, 0, 8, 13, 12, 13, 0, 0, 8, 13, 0, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 0, 3, 4, 4, 0 ]

[ "This", "event", ",", "which", "is", "negatively", "regulated", "by", "antiapoptotic", "Bcl-2", "family", "members", "(", "e.g.", ",", "Bcl-2", ")", ",", "results", "in", "the", "release", "of", "proapoptotic", "proteins", "(", "cytochrome", "c", "[", "cytoc", "]", "and", "Smac", ")", "from", "mitochondria", "into", "the", "cytosol", "." ]

[ 6, 8, 13, 11, 3, 2, 16, 1, 0, 12, 8, 8, 13, 17, 13, 12, 13, 13, 16, 1, 6, 8, 1, 0, 8, 13, 8, 8, 17, 12, 17, 5, 12, 13, 1, 8, 1, 6, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "One", "such", "pathway", "is", "the", "Jak/Stat3", "(", "Janus", "kinase", "/", "signal", "transducer", "and", "activator", "of", "transcription-3", ")", "pathway", "[", "5", "]", "." ]

[ 9, 0, 8, 3, 6, 12, 13, 12, 8, 15, 8, 8, 5, 8, 1, 8, 13, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0 ]

[ "Lung", "volume", ",", "mean", "lung", "density", ",", "full", "-", "width", "-", "at", "-", "half", "-", "maximum", "and", "low", "attenuated", "volume", "(", "LAV", ")", "were", "semi", "-", "automated", "quantified", "in", "151", "patients", ".", "qCT", "values", "between", "different", "age", "groups", "as", "well", "as", "unenhanced", "(", "Group", "1", ")", "and", "contrast", "-", "enhanced", "(", "Group", "2", ")", "protocols", "were", "compared", "." ]

[ 8, 8, 13, 0, 8, 8, 13, 0, 13, 8, 13, 1, 13, 0, 13, 8, 5, 0, 16, 8, 13, 12, 13, 3, 0, 13, 0, 16, 1, 9, 8, 13, 12, 8, 1, 0, 8, 8, 1, 2, 1, 0, 13, 12, 9, 13, 5, 8, 13, 16, 13, 12, 9, 13, 8, 3, 16, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "IVW", ",", "inverse", "-", "variance", "weighted", ";", "MR", ",", "Mendelian", "randomization", ";", "OR", ",", "odds", "ratio", "." ]

[ 12, 13, 0, 13, 8, 16, 13, 12, 13, 0, 8, 13, 12, 13, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0 ]

[ "In", "contrast", ",", "an", "ectopic", "domain", "of", "FGF4", "persists", "in", "the", "anterior", "apical", "ectodermal", "ridge", "(", "AER", ")", "(", "Figure", "4H–4J", ")", ".", "Thus", "the", "defects", "in", "limb", "patterning", "result", "from", "disruption", "of", "a", "step", "downstream", "of", "Shh", ",", "Ptc1", ",", "gremlin", ",", "and", "Bmp4", ",", "and", "upstream", "of", "Fgf4", "." ]

[ 1, 8, 13, 6, 0, 8, 1, 12, 16, 1, 6, 0, 0, 0, 8, 13, 12, 13, 13, 8, 9, 13, 13, 2, 6, 8, 1, 8, 8, 16, 1, 8, 1, 6, 8, 2, 1, 12, 13, 8, 13, 8, 13, 5, 8, 13, 5, 2, 1, 12, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "more", "directly", "test", "this", ",", "we", "used", "MicroScale", "Thermophoresis", "(", "MST", ")", "[", "29,30", "]", "." ]

[ 10, 2, 2, 16, 11, 13, 11, 16, 12, 12, 13, 12, 13, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0 ]

[ "Immunodeficient", "mouse", "model", "was", "established", "using", "cyclophosphamide", "and", "mice", "gastric", "mucosal", "cells", "were", "infected", "with", "Mycoplasma", "penetrans", "(", "Mpe", ")", "." ]

[ 0, 8, 8, 3, 16, 16, 8, 5, 8, 0, 0, 8, 3, 16, 1, 8, 0, 13, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0 ]

[ "Compared", "with", "patients", "with", "no", "phonemic", "impairment", ",", "patients", "with", "phonemic", "impairment", "exhibited", "a", "significant", "decrease", "in", "postoperative", "metabolism", "in", "the", "right", "middle", "occipital", "gyrus", "(", "Brodmann", "areas", "(", "BAs", ")", "19", "and", "37", ")", ",", "right", "fusiform", "gyrus", "(", "BA", "18", ")", "and", "right", "superior", "temporal", "gyrus", "(", "BAs", "21", ",", "22", "and", "42", ")", "(", "Table", "4", ",", "Fig", "1A", ")", "." ]

[ 16, 1, 8, 1, 6, 0, 8, 13, 8, 1, 0, 8, 16, 6, 0, 8, 1, 0, 8, 1, 6, 0, 0, 0, 8, 13, 12, 8, 13, 12, 13, 9, 5, 9, 13, 13, 0, 0, 8, 13, 12, 9, 13, 5, 0, 0, 0, 8, 13, 12, 9, 13, 9, 5, 9, 13, 13, 8, 9, 13, 8, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Topotecan", "or", "amrubicin", ",", "and", "a", "combination", "of", "cyclophosphamide", ",", "doxorubicin", "and", "vincristine", "(", "CAV", ")", "constitute", "second", "-", "line", "therapy;[2", "]", "however", ",", "these", "chemotherapies", "have", "not", "conclusively", "demonstrated", "superiority", "over", "topotecan", "in", "a", "RCT", "setting", ",", "which", "itself", "provides", "only", "modest", "outcomes.[13", ",", "14", "]", "In", "third", "line", "and", "beyond", ",", "there", "is", "a", "paucity", "of", "high", "-", "quality", "evidence", "to", "guide", "treatment", "decisions.[15", "]", "Additionally", ",", "the", "rates", "of", "relapse", "of", "SCLC", "within", "two", "years", "are", "high", "and", "the", "prognosis", "with", "current", "treatments", "remains", "poor", "across", "all", "lines", "of", "therapy", ",", "with", "the", "median", "survival", "time", "reported", "in", "RCTs", "varying", "from", "12.9", "to", "20", "months", "in", "first", "-", "line", "patients", "with", "LD", "-", "SCLC", "and", "from", "7.9", "to", "12.8", "months", "in", "first", "-", "line", "patients", "with", "ED", "-", "SCLC", ",", "both", "treated", "with", "platinum", "-", "based", "regimens.[11", ",", "12", "]", "In", "second", "line", ",", "RCTs", "report", "a", "median", "survival", "time", "between", "15", "and", "20", "months", "for", "LD", "-", "SCLC", ",", "and", "9.4", "to", "12.8", "months", "for", "patients", "with", "ED", "-", "SCLC", ",", "both", "treated", "with", "platinum", "-", "based", "regimens.[2", "]", "Recent", "literature", "suggests", "that", "real", "-", "world", "outcomes", "in", "cancer", "patients", "are", "equally", "modest", ",", "with", "surrogate", "outcomes", "being", "even", "poorer", "than", "reported", "in", "RCTs.[16", "]", "It", "is", "expected", "that", "SCLC", "patient", "outcomes", "in", "the", "real", "world", "will", "be", "equally", "poor", "." ]

[ 12, 5, 8, 13, 5, 6, 8, 1, 8, 13, 8, 5, 8, 13, 12, 13, 16, 0, 13, 8, 17, 13, 2, 13, 6, 8, 3, 10, 2, 16, 8, 1, 12, 1, 6, 12, 8, 13, 11, 11, 16, 2, 0, 17, 13, 17, 13, 1, 0, 8, 5, 1, 13, 11, 3, 6, 8, 1, 0, 13, 8, 8, 10, 16, 8, 8, 13, 2, 13, 6, 8, 1, 8, 1, 12, 1, 9, 8, 3, 0, 5, 6, 8, 1, 0, 8, 16, 0, 1, 6, 8, 1, 8, 13, 1, 6, 0, 8, 8, 16, 1, 12, 16, 1, 9, 10, 9, 8, 1, 0, 13, 8, 8, 1, 12, 13, 12, 5, 1, 9, 10, 9, 8, 1, 0, 13, 8, 8, 1, 12, 13, 12, 13, 11, 16, 1, 8, 13, 16, 8, 13, 9, 13, 1, 0, 8, 13, 12, 16, 6, 0, 8, 8, 1, 9, 5, 9, 8, 1, 12, 13, 12, 13, 5, 9, 10, 9, 8, 1, 8, 1, 12, 13, 12, 13, 11, 16, 1, 8, 13, 16, 8, 13, 0, 8, 16, 14, 0, 13, 8, 8, 1, 8, 8, 3, 2, 0, 13, 1, 0, 8, 3, 2, 0, 14, 16, 1, 12, 13, 11, 3, 16, 14, 12, 8, 8, 1, 6, 0, 8, 3, 3, 2, 0, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "R.", "erythropolis", "strain", "MI2", "was", "isolated", ",", "and", "later", "applied", "in", "polythioester", "(", "PTE", ")", "research", ",", "because", "this", "strain", "exhibits", "the", "rare", "ability", "to", "use", "the", "synthetic", "disulfide", "4,4´-dithiodibutyric", "acid", "(", "DTDB", ")", "as", "sole", "carbon", "source", "and", "electron", "donor", "for", "aerobic", "growth", "[", "9", ",", "10", "]", "." ]

[ 12, 8, 8, 12, 3, 16, 13, 5, 2, 16, 1, 8, 13, 12, 13, 8, 13, 14, 6, 8, 16, 6, 0, 8, 10, 16, 6, 0, 8, 8, 8, 13, 12, 13, 1, 0, 8, 8, 5, 8, 8, 1, 0, 8, 13, 9, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Proportion", "of", "patients", "meeting", "at", "least", "one", "of", "nine", "indicators", "of", "high", "-", "risk", "NSAID", "and", "anti", "-", "platelet", "prescribing", ":", "prescription", "of", "a", "traditional", "oral", "NSAID", "or", "low", "-", "dose", "aspirin", "in", "patients", "with", "a", "history", "of", "peptic", "ulceration", "without", "co", "-", "prescription", "of", "gastro", "-", "protection;traditional", "oral", "NSAID", "in", "patients", "aged", "75", "years", "or", "over", "without", "co", "-", "prescription", "of", "gastro", "-", "protection;traditional", "oral", "NSAID", "and", "aspirin", "in", "patients", "aged", "65", "years", "or", "over", "without", "co", "-", "prescription", "of", "gastro", "-", "protection;aspirin", "and", "clopidogrel", "in", "patients", "aged", "65", "years", "or", "over", "without", "co", "-", "prescription", "of", "gastro", "-", "protection;warfarin", "and", "traditional", "oral", "NSAID;warfarin", "and", "low", "-", "dose", "aspirin", "or", "clopidogrel", "without", "co", "-", "prescription", "of", "gastro", "-", "protection;oral", "NSAID", "in", "patients", "with", "heart", "failure;oral", "NSAID", "in", "patients", "prescribed", "both", "a", "diuretic", "and", "an", "angiotensin", "-", "converting", "-", "enzyme", "inhibitor", "(", "ACE-I", ")", "or", "angiotensin", "receptor", "blocker", "(", "ARB);oral", "NSAID", "in", "patients", "with", "chronic", "kidney", "disease", "(", "CKD", ")", "." ]

[ 8, 1, 8, 16, 1, 2, 9, 1, 9, 8, 1, 0, 13, 8, 12, 5, 0, 13, 0, 8, 13, 8, 1, 6, 0, 0, 12, 5, 0, 13, 8, 8, 1, 8, 1, 6, 8, 1, 0, 8, 1, 8, 13, 8, 1, 8, 13, 8, 0, 12, 1, 8, 16, 9, 8, 5, 2, 1, 8, 13, 8, 1, 8, 13, 8, 0, 12, 5, 8, 1, 8, 16, 9, 8, 5, 2, 1, 8, 13, 8, 1, 8, 13, 8, 5, 8, 1, 8, 16, 9, 8, 5, 2, 1, 8, 13, 8, 1, 8, 13, 8, 5, 0, 0, 12, 5, 0, 13, 8, 8, 5, 8, 1, 8, 13, 8, 1, 8, 13, 8, 12, 1, 8, 1, 8, 8, 12, 1, 8, 16, 5, 6, 0, 5, 6, 8, 13, 16, 13, 8, 8, 13, 12, 13, 5, 8, 8, 8, 13, 12, 12, 1, 8, 1, 0, 8, 8, 13, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 1, 0, 0, 3, 4, 4, 0, 1, 1, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0 ]

[ "Stored", "samples", "were", "used", "to", "measure", "six", "biomarkers", ":", "high", "sensitivity", "C", "-", "reactive", "protein", "(", "hsCRP", ")", ",", "interleukin-6", "(", "IL-6", ")", ",", "amyloid", "A", ",", "amyloid", "P", ",", "D", "-", "dimer", ",", "and", "prothrombin", "fragment", "1", "+", "2", "." ]

[ 16, 8, 3, 16, 10, 16, 9, 8, 13, 0, 8, 8, 13, 0, 8, 13, 12, 13, 13, 8, 13, 12, 13, 13, 8, 8, 13, 8, 8, 13, 8, 13, 8, 13, 5, 8, 8, 9, 9, 9, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 1, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Individuals", "with", "mild", "cognitive", "impairment", "(", "MCI", ")", "have", "a", "substantially", "increased", "risk", "of", "developing", "dementia", "due", "to", "Alzheimer", "'s", "disease", "(", "AD", ")", ".", "In", "this", "study", ",", "we", "developed", "a", "multivariate", "prognostic", "model", "for", "predicting", "MCI", "-", "to", "-", "dementia", "progression", "at", "the", "individual", "patient", "level", "." ]

[ 8, 1, 0, 0, 8, 13, 12, 13, 16, 6, 2, 16, 8, 1, 16, 8, 1, 1, 12, 10, 8, 13, 12, 13, 13, 1, 6, 8, 13, 11, 16, 6, 0, 0, 8, 1, 16, 12, 13, 1, 13, 8, 8, 1, 6, 0, 8, 8, 13 ]

[ 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Regarding", "outcome", "of", "donors", "with", "vascular", "multiplicity", ",", "warm", "ischemia", "time", "(", "WIT", ")", "and", "skin", "-", "to", "-", "skin", "time", "were", "significantly", "longer", "if", "arterial", "multiplicity", "(", "AM", ")", "was", "present", "(", "5.1", "vs.", "4.0", "mins", "and", "202", "vs.", "178", "mins", ")", "." ]

[ 16, 8, 1, 8, 1, 0, 8, 13, 0, 8, 8, 13, 12, 13, 5, 8, 13, 1, 13, 8, 8, 3, 2, 0, 14, 0, 8, 13, 12, 13, 3, 0, 13, 9, 1, 9, 8, 5, 9, 1, 9, 8, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Ker-EGI", ",", "Ker", "-", "electromyography", "gait", "index", ";", "EMG", ",", "electromyography", "profile", "score", "." ]

[ 12, 13, 12, 13, 8, 8, 8, 13, 12, 13, 8, 8, 8, 13 ]

[ 1, 0, 3, 4, 3, 4, 4, 0, 1, 0, 3, 0, 0, 0 ]

[ "Though", "putative", "Pho4", "binding", "sequences", "are", "present", "at", "−464", "and", "−154", "in", "its", "promoter", ",", "VIP1", "expression", "was", "dependent", "on", "neither", "Pi", "condition", "nor", "Pho4", "(", "unpublished", "data", ")", ",", "as", "in", "the", "case", "of", "the", "KCS1", "mRNA", ".", "Inositol", "polyphosphate", "(", "IP", ")", "plays", "an", "important", "role", "in", "intracellular", "signal", "transduction", "as", "second", "messengers", "." ]

[ 14, 0, 12, 16, 8, 3, 0, 1, 9, 5, 9, 1, 11, 8, 13, 12, 8, 3, 0, 1, 5, 12, 8, 5, 12, 13, 0, 8, 13, 13, 1, 1, 6, 8, 1, 6, 12, 8, 13, 8, 8, 13, 12, 13, 16, 6, 0, 8, 1, 0, 8, 8, 1, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "proopiomelanocortin", "gene", "(", "POMC", ")", "is", "expressed", "in", "the", "pituitary", "gland", "and", "the", "ventral", "hypothalamus", "of", "all", "jawed", "vertebrates", ",", "producing", "several", "bioactive", "peptides", "that", "function", "as", "peripheral", "hormones", "or", "central", "neuropeptides", ",", "respectively", "." ]

[ 6, 8, 8, 13, 12, 13, 3, 16, 1, 6, 0, 8, 5, 6, 0, 8, 1, 6, 0, 8, 13, 16, 0, 0, 8, 11, 16, 1, 0, 8, 5, 0, 8, 13, 2, 13 ]

[ 0, 3, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Functional", "studies", "of", "the", "adenosine", "A3", "receptor", "in", "the", "coronary", "blood", "vessels", "was", "performed", "using", "tissues", "from", "10", "week", "-", "old", "male", "spontaneously", "hypertensive", "rats", "(", "SHRs", ")", "and", "age", "-", "matched", "Wistar", "rats", "(", "ARC", ",", "Australia", ")", "." ]

[ 0, 8, 1, 6, 8, 8, 8, 1, 6, 0, 8, 8, 3, 16, 16, 8, 1, 9, 8, 13, 0, 0, 2, 0, 8, 13, 12, 13, 5, 8, 13, 16, 12, 8, 13, 12, 13, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Hedgehog", "(", "Hh", ")", "proteins", "function", "as", "morphogens", "and", "play", "critical", "roles", "in", "pattern", "formation", "and", "cell", "growth", "control", "." ]

[ 12, 13, 12, 13, 8, 16, 1, 8, 5, 16, 0, 8, 1, 8, 8, 5, 8, 8, 8, 13 ]

[ 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Illumina", ")", ",", "and", "the", "centromeric", "and", "some", "of", "subtelomeric", "regions", "are", "still", "incompletely", "assembled", ",", "which", "is", "the", "likely", "reason", "for", "the", "weak", "patterns", "seen", "at", "some", "chromosome", "termini", "(", "for", "example", ",", "both", "termini", "of", "chr2", ")", ".", "chr2", ",", "Chromosome", "2", ";", "CSG", ",", "conserved", "genes", ";", "FPKM", ",", "fragments", "per", "kilobase", "of", "exon", "per", "million", "reads", "mapped", ";", "GE", ",", "gene", "expression", ";", "IES", ",", "internal", "eliminated", "sequence", ";", "Ka", ",", "ratio", "of", "nonsynonymous", "to", "synonymous", "substitutions", ";", "/KsLRR", ",", "leucine", "-", "rich", "repeat", ";", "MIC", ",", "micronucleus", ";", "SPP", ",", "Super", "Proteose", "Peptone", ";", "SSG", ",", "species", "-", "specific", "gene", "." ]

[ 8, 13, 13, 5, 6, 0, 5, 6, 1, 0, 8, 3, 2, 2, 16, 13, 11, 3, 6, 0, 8, 1, 6, 0, 8, 16, 1, 6, 8, 8, 13, 1, 8, 13, 6, 8, 1, 12, 13, 13, 12, 13, 12, 9, 13, 12, 13, 16, 8, 13, 12, 13, 8, 1, 8, 1, 8, 1, 9, 8, 16, 13, 12, 13, 8, 8, 13, 12, 13, 0, 16, 8, 13, 12, 13, 8, 1, 0, 1, 0, 8, 13, 12, 13, 8, 13, 0, 8, 13, 12, 13, 8, 13, 12, 13, 12, 12, 8, 13, 12, 13, 8, 13, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 4, 4, 4, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 0, 1, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Abbreviations", ":", "BIC", ",", "Bayesian", "information", "criterion", ";", "MCMC", ",", "Markov", "chain", "Monte", "Carlo", "." ]

[ 8, 13, 12, 13, 0, 8, 8, 13, 12, 13, 12, 8, 12, 12, 13 ]

[ 0, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 4, 0 ]

[ "Most", "patients", "were", "switched", "from", "a", "first", "-", "line", "regimen", "of", "ZDV/3TC", "/", "TDF", "to", "second", "-", "line", "regimens", "containing", "efavirenz", "(", "EFV", ")", "and", "either", "didanosine", "(", "ddI", ")", "or", "lamivudine", "(", "3TC", ")", "with", "ritonavir", "boosted", "lopinavir", "(", "LPV", ")", "." ]

[ 0, 8, 3, 16, 1, 6, 0, 13, 8, 8, 1, 8, 15, 12, 1, 0, 13, 8, 8, 16, 8, 13, 12, 13, 5, 5, 8, 13, 8, 13, 5, 8, 13, 8, 13, 1, 8, 16, 8, 13, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 3, 0, 1, 0, 0 ]

[ "Abbreviations", ":", "HR", ",", "hazard", "ratio", ";", "PE", ",", "pulmonary", "embolism", ";", "PWH", ",", "people", "with", "HIV", ";", "VTE", ",", "venous", "thromboembolism" ]

[ 8, 13, 12, 13, 8, 8, 13, 12, 13, 0, 8, 13, 12, 13, 8, 1, 12, 13, 12, 13, 0, 8 ]

[ 0, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4 ]

[ "There", "are", "several", "common", "steps", "for", "steroid", "biosynthesis", "between", "adrenals", "and", "gonads", ",", "including", "initial", "steps", "catalyzed", "by", "mitochondrial", "P450", "cholesterol", "side", "chain", "cleavage", "enzyme", "(", "CYP11A1", ")", "and", "smooth", "endoplasmic", "reticulum", "enzyme", "3β", "-", "hydroxysteroid", "dehydrogenase", "(", "HSD3B", ")", ".", "Due", "to", "these", "common", "enzymes", "and", "the", "common", "substrate", ",", "cholesterol", ",", "to", "begin", "with", "in", "both", "systems", ",", "it", "is", "highly", "likely", "that", "etomidate", "may", "also", "affect", "reproductive", "system", "." ]

[ 11, 16, 0, 0, 8, 1, 8, 8, 1, 8, 5, 8, 13, 16, 0, 8, 16, 1, 0, 8, 8, 8, 8, 8, 8, 13, 12, 13, 5, 0, 0, 8, 8, 8, 8, 8, 8, 13, 12, 13, 13, 1, 10, 6, 0, 8, 5, 6, 0, 8, 13, 8, 13, 10, 16, 1, 1, 6, 8, 13, 11, 3, 2, 0, 14, 8, 3, 2, 16, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Recently", "hybrid", "methods", ",", "using", "a", "combination", "of", "theoretical", "knowledge", "and", "statistical", "approaches", "to", "determine", "dietary", "patterns", "were", "proposed", ",", "such", "as", "reduced", "rank", "regression", "(", "RRR", ")", ".", "This", "method", "aims", "to", "construct", "linear", "functions", "of", "foods", "that", "best", "explain", "the", "variations", "in", "the", "outcome", "variables", "(", "such", "as", "a", "disease", "-", "related", "nutrient", ",", "subclinical", "or", "clinical", "endpoints", ")", "." ]

[ 2, 0, 8, 13, 16, 6, 8, 1, 0, 8, 5, 0, 8, 10, 16, 0, 8, 3, 16, 13, 0, 1, 16, 8, 8, 13, 12, 13, 13, 6, 8, 16, 10, 16, 0, 8, 1, 8, 11, 2, 16, 6, 8, 1, 6, 8, 8, 13, 0, 1, 6, 8, 13, 16, 8, 13, 0, 5, 0, 8, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "the", "transcriptome", "cohort", ",", "20", "critically", "injured", "patients", "later", "developed", "MODS", ".", "Compared", "with", "the", "16", "patients", "who", "did", "not", "develop", "MODS", "MODS", "(", "NoMODS", ")", ",", "maximal", "differential", "expression", "was", "seen", "within", "the", "hyperacute", "window", "." ]

[ 1, 6, 8, 8, 13, 9, 2, 16, 8, 2, 16, 12, 13, 16, 1, 6, 9, 8, 11, 3, 10, 16, 12, 12, 13, 12, 13, 13, 0, 0, 8, 3, 16, 1, 6, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "primary", "subjective", "outcome", "measures", "were", "cognitive", "functioning", "(", "Cognitive", "Failure", "Questionnaire", ")", ",", "executive", "functioning", "(", "Dysexecutive", "Functioning", "Questionnaire", ")", ",", "quality", "of", "life", "(", "Short", "Form", "Health", "Survey", ")", ",", "instrumental", "activities", "of", "daily", "living", "(", "IADL", ";", "Lawton", "&", "Brody", "IADL", "scale", ")", ",", "and", "participation", "in", "society", "(", "Utrecht", "Scale", "for", "Evaluation", "of", "Rehabilitation", "-", "Participation", ")", "." ]

[ 6, 0, 0, 8, 8, 3, 0, 8, 13, 12, 12, 12, 13, 13, 0, 8, 13, 12, 12, 12, 13, 13, 8, 1, 8, 13, 12, 12, 12, 12, 13, 13, 0, 8, 1, 0, 8, 13, 12, 13, 12, 5, 12, 12, 8, 13, 13, 5, 8, 1, 8, 13, 12, 12, 1, 12, 1, 12, 13, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "contrast", ",", "reparative", "macrophages", ",", "responsible", "for", "preserving", "the", "structural", "integrity", "of", "the", "injured", "ventricle", "by", "promoting", "cardiac", "repair", "through", "myofibroblasts", "induction", ",", "collagen", "deposition", ",", "and", "neovascularization", ",", "dominate", "the", "heart", "at", "day", "5", "to", "7", "post", "-", "MI", "and", "secrete", "high", "level", "of", "anti", "-", "inflammatory", "cytokines", "and", "angiogenic", "factors", "such", "as", "IL-10", ",", "vascular", "endothelial", "growth", "factor", "(", "VEGF", ")", ",", "fibroblast", "growth", "factor", "2", "(", "FGF2", ")", ",", "and", "transforming", "growth", "factor", "beta", "(", "TGFβ", ")", "[", "3,11,14–18", "]", "." ]

[ 1, 8, 13, 0, 8, 13, 0, 1, 16, 6, 0, 8, 1, 6, 16, 8, 1, 16, 0, 8, 1, 8, 8, 13, 8, 8, 13, 5, 8, 13, 16, 6, 8, 1, 8, 9, 1, 9, 0, 0, 12, 5, 16, 0, 8, 1, 0, 0, 0, 8, 5, 0, 8, 0, 1, 12, 13, 0, 0, 8, 8, 13, 12, 13, 13, 8, 8, 8, 9, 13, 12, 13, 13, 5, 16, 8, 8, 8, 13, 12, 13, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0 ]

[ "COPD", ",", "chronic", "obstructive", "pulmonary", "disease", ";", "CPRD", ",", "Clinical", "Practice", "Research", "Datalink", ";", "HES", ",", "Hospital", "Episode", "Statistics", ";", "ICS", ",", "inhaled", "corticosteroid" ]

[ 12, 13, 0, 0, 0, 8, 13, 12, 13, 12, 12, 12, 12, 13, 12, 13, 12, 12, 12, 13, 12, 13, 16, 8 ]

[ 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4 ]

[ "Based", "on", "the", "v", "-", "TD", "defined", "by", "MRI", "at", "3", "months", "after", "PBT", ",", "we", "hypothesized", "the", "irradiated", "liver", "area", "receiving", "a", "dose", "greater", "than", "the", "v", "-", "TD", "isodose", "lines", "at", "planning", "MRI", "as", "the", "destined", "FLR", "area", "FLR", "(", "dFLR", ")", ".", "The", "volume", "of", "the", "dFLR", "was", "calculated", "and", "compared", "with", "the", "FLR", "volume", "on", "follow", "-", "up", "MRI", ".", "To", "determine", "intra", "-", "observer", "reproducibility", "when", "measuring", "FLR", "volume", ",", "FLR", "volumes", "were", "delineated", "and", "measured", "twice", "at", "1", "month", "intervals", ",", "and", "the", "mean", "values", "of", "each", "set", "of", "measurements", "were", "used", "." ]

[ 16, 1, 6, 8, 0, 12, 16, 1, 8, 1, 9, 8, 1, 12, 13, 11, 16, 6, 16, 8, 8, 16, 6, 8, 0, 1, 6, 8, 0, 12, 8, 8, 1, 16, 8, 1, 6, 16, 12, 8, 12, 13, 12, 13, 13, 6, 8, 1, 6, 12, 3, 16, 5, 16, 1, 6, 12, 8, 1, 16, 0, 1, 8, 13, 10, 16, 0, 0, 0, 8, 14, 16, 12, 8, 13, 12, 8, 3, 16, 5, 16, 2, 1, 9, 8, 8, 13, 5, 6, 0, 8, 1, 6, 8, 1, 8, 3, 16, 13 ]

[ 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 1, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Current", "initiatives", "to", "tackle", "ABR", "in", "Asia", "aim", "to", "set", "up", "surveillance", "systems", ",", "regulate", "the", "sale", "of", "antibiotics", ",", "and", "introduce", "national", "guidelines", "for", "antibiotic", "use", ",", "but", "fail", "to", "take", "into", "account", "patient", "perceptions", "and", "expectations", "from", "health", "providers", "as", "a", "major", "driver", "for", "ABR", ".", "Any", "effort", "to", "tackle", "antibiotic", "resistance", "must", "also", "include", "patient", "education", "and", "counseling", ",", "as", "patient", "demands", "are", "a", "major", "driver", "for", "overuse", "of", "antibiotics", "among", "formal", "and", "informal", "health", "providers", "alike", "." ]

[ 0, 8, 10, 16, 12, 1, 12, 16, 10, 16, 1, 8, 8, 13, 16, 6, 8, 1, 8, 13, 5, 16, 0, 8, 1, 0, 8, 13, 5, 16, 10, 16, 1, 8, 8, 8, 5, 8, 1, 8, 8, 14, 6, 0, 8, 1, 12, 13, 6, 8, 10, 16, 0, 8, 3, 2, 16, 8, 8, 5, 8, 13, 14, 8, 8, 3, 6, 0, 8, 1, 8, 1, 8, 1, 0, 5, 0, 8, 8, 2, 13 ]

[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "do", "this", "we", "employed", "a", "bub1ΔK", "strain", "containing", "Tub1", "-", "cyan", "fluorescent", "protein", "(", "CFP", ")", "to", "label", "spindle", "microtubules", "and", "Mtw1", "-", "3xGFP", "to", "mark", "all", "kinetochores", "." ]

[ 10, 16, 11, 11, 16, 6, 8, 8, 16, 8, 13, 8, 0, 8, 13, 12, 13, 10, 16, 8, 8, 5, 12, 13, 8, 10, 16, 6, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "also", "monitored", "expression", "of", "the", "mitochondrial", "adenine", "nucleotide", "transporter", "(", "ANT", ")", ".", "All", "target", "antigens", "are", "nuclear", "encoded", "except", "subunit", "I", "of", "complex", "IV", ",", "which", "is", "mitochondrially", "encoded", "." ]

[ 11, 2, 16, 8, 1, 6, 0, 8, 8, 8, 13, 12, 13, 13, 6, 8, 8, 3, 8, 16, 14, 8, 9, 1, 8, 9, 13, 11, 3, 2, 16, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Clustering", "of", "samples", "by", "the", "50", "most", "significant", "DE", "genes", "reveals", "multiple", "gene", "expression", "clusters", "among", "SARS", "positive", "samples", ",", "while", "most", "negative", "samples", "cluster", "together", "(", "Fig", "1A", ")", ".", "Consistent", "with", "results", "from", "Butler", "and", "colleagues", "[", "20", "]", ",", "-CoV-2SARS", "infection", "induces", "an", "interferon", "-", "driven", "antiviral", "response", "in", "the", "nasopharynx", ",", "up", "-", "regulating", "transcripts", "encoding", "viral", "sensors", "(", "IFIT1", ",", "DDX58", ")", ",", "chemokines", "that", "attract", "effector", "T", "cells", "and", "natural", "killer", "(", "-CoV-2NK", ")", "cells", "(", "CXCL9", ",", "10", ",", "11", ")", ",", "and", "direct", "inhibitors", "of", "viral", "replication", "and", "function", "(", "MX2", ",", "RSAD2", ",", "HERC5", ")", ",", "highlighted", "in", "Fig", "1A", "and", "1B." ]

[ 8, 1, 8, 1, 6, 9, 0, 0, 12, 8, 16, 0, 8, 8, 8, 1, 12, 0, 8, 13, 14, 0, 0, 8, 16, 2, 13, 8, 9, 13, 13, 0, 1, 8, 1, 12, 5, 8, 13, 9, 13, 13, 12, 8, 16, 6, 8, 13, 16, 0, 8, 1, 6, 8, 13, 8, 13, 16, 8, 16, 0, 8, 13, 12, 13, 12, 13, 13, 8, 11, 16, 8, 8, 8, 5, 0, 8, 13, 12, 13, 8, 13, 12, 13, 9, 13, 9, 13, 13, 5, 0, 8, 1, 0, 8, 5, 8, 13, 12, 13, 12, 13, 12, 13, 13, 16, 1, 8, 9, 5, 8 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "PK", "data", "were", "also", "fit", "to", "a", "two", "-", "compartment", "model", "using", "the", "computer", "program", "NONMEM", "7.3", "(", "ICON", ",", "Dublin", ")", "to", "estimate", "clearance", "and", "the", "elimination", "half", "-", "life", "(", "t1/2β", ")", "." ]

[ 6, 12, 8, 3, 2, 0, 10, 6, 9, 13, 8, 8, 16, 6, 8, 8, 12, 9, 13, 12, 13, 12, 13, 10, 16, 8, 5, 6, 8, 0, 13, 8, 13, 12, 13, 13 ]

[ 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0 ]

[ "Indicated", "mice", "were", "intraperitoneal", "(", "IP", ")", "injected", "with", "vehicle", ",", "XMU", "-", "MP-1", "(", "1", "mg", "/", "kg", ",", "once", "a", "day", ",", "S8334", ",", "Selleck", ",", "Houston", ",", "Texas", ",", "USA", ")", ",", "SB431542", "(", "4.2", "mg", "/", "kg", ",", "once", "a", "day", ",", "S1067", ",", "Selleck", ")", ",", "and", "Anti", "-", "IFNAR1", "(", "0.2", "mg", "/", "mouse", ",", "once", "every", "2", "days", ",", "BE0241", ",", "Bio", "X", "Cell", ",", "Lebanon", ",", "New", "Hampshire", ",", "USA", ")", "throughout", "the", "study", "." ]

[ 16, 8, 3, 0, 13, 12, 13, 16, 1, 8, 13, 12, 12, 12, 13, 9, 8, 15, 8, 13, 2, 6, 8, 13, 12, 13, 12, 13, 12, 13, 12, 13, 12, 13, 13, 12, 13, 9, 8, 15, 8, 13, 2, 6, 8, 13, 12, 13, 12, 13, 13, 5, 12, 12, 12, 13, 9, 8, 15, 8, 13, 2, 6, 9, 8, 13, 12, 13, 12, 12, 12, 13, 12, 13, 12, 12, 13, 12, 13, 1, 6, 8, 13 ]

[ 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "cornerstone", "of", "global", "TB", "control", "efforts", "led", "by", "the", "World", "Health", "Organization", "(", "WHO", ")", "is", "the", "DOTS", "strategy", ",", "which", "relies", "on", "short", "-", "course", "chemotherapy", "for", "individuals", "with", "active", "pulmonary", "TB", ",", "with", "drugs", "administered", "under", "the", "direct", "observation", "of", "health", "workers", "." ]

[ 6, 8, 1, 0, 12, 8, 8, 16, 1, 6, 12, 12, 12, 13, 12, 13, 3, 6, 12, 8, 13, 11, 16, 1, 0, 13, 8, 8, 1, 8, 1, 0, 0, 12, 13, 1, 8, 16, 1, 6, 0, 8, 1, 8, 8, 13 ]

[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Additionally", ";", "malaria", "causes", "significant", "economic", "losses", ",", "and", "can", "decrease", "the", "gross", "domestic", "product", "(", "GDP", ")", "by", "as", "much", "as", "1.3", "%", "in", "countries", "with", "high", "levels", "of", "transmission", "[", "4", "]", "." ]

[ 2, 13, 8, 16, 0, 0, 8, 13, 5, 3, 16, 6, 0, 0, 8, 13, 12, 13, 1, 1, 0, 1, 9, 8, 1, 8, 1, 0, 8, 1, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "involves", "the", "delivery", "of", "health", "information", "by", "using", "mobile", "phones", "’", "short", "message", "service", "(", "SMS", ")", ",", "patient", "monitoring", "devices", ",", "and", "internet", "-", "based", "components", "(", "social", "media", ",", "computer", "software", ",", "websites", ",", "mobile", "apps", ",", "games", ",", "and", "chat", "rooms", ")", "[", "27", "]", "." ]

[ 11, 16, 6, 8, 1, 8, 8, 1, 16, 0, 8, 13, 0, 8, 8, 13, 12, 13, 13, 8, 8, 8, 13, 5, 8, 13, 16, 8, 13, 0, 8, 13, 8, 8, 13, 8, 13, 0, 8, 13, 8, 13, 5, 8, 8, 13, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Hyperpolarization", "of", "HCs", "by", "light", "shifts", "the", "activation", "potential", "of", "the", "presynaptic", "Ca2", "+", "current", "(", "ICa", ")", "in", "cones", "to", "more", "negative", "potentials", "[", "1]–[5", "]", ",", "leading", "to", "a", "larger", "ICa", ".", "This", "increases", "the", "Ca2", "+", "concentration", "in", "the", "cone", "synaptic", "terminal", "so", "more", "glutamate", "is", "released", "." ]

[ 8, 1, 12, 1, 8, 16, 6, 8, 8, 1, 6, 0, 8, 8, 8, 13, 12, 13, 1, 8, 1, 0, 0, 8, 17, 17, 13, 13, 16, 1, 6, 0, 12, 13, 11, 16, 6, 8, 8, 8, 1, 6, 8, 0, 8, 14, 0, 8, 3, 16, 13 ]

[ 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Moreover", ",", "the", "NLRP3", "inflammasome", "is", "engaged", "by", "gram", "-", "negative", "pathogens", ",", "lipopolysaccharides", "(", "LPS", ")", "that", "are", "sensed", "in", "the", "cytosol", "by", "the", "non", "-", "canonical", "NLRP3", "inflammasome", "pathway", "[", "5–8", "]", "." ]

[ 2, 13, 6, 12, 8, 3, 16, 1, 8, 0, 0, 8, 13, 8, 13, 12, 13, 11, 3, 16, 1, 6, 8, 1, 6, 0, 0, 0, 12, 8, 8, 17, 9, 13, 13 ]

[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "Huanglongbing", "(", "HLB", ")", "is", "the", "most", "serious", "disease", "affecting", "citrus", "production", "worldwide", "." ]

[ 12, 13, 12, 13, 3, 6, 2, 0, 8, 16, 8, 8, 2, 13 ]

[ 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "the", "United", "Kingdom", "Prospective", "Diabetes", "Study", "(", "UKPDS", ")", "[", "49", "]", ",", "development", "of", "DR", "was", "strongly", "associated", "with", "baseline", "glycaemia", ",", "glycemic", "exposure", "over", "6", "years", ",", "higher", "blood", "pressure", "and", "being", "a", "non", "smoker", "." ]

[ 1, 6, 12, 12, 12, 12, 12, 13, 12, 13, 13, 9, 13, 13, 8, 1, 12, 3, 2, 16, 1, 0, 8, 13, 0, 8, 1, 9, 8, 13, 0, 8, 8, 5, 3, 6, 0, 8, 13 ]

[ 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "test", "the", "hypothesis", "whether", "a", "loss", "of", "function", "of", "Su(fu", ")", "was", "able", "to", "phenocopy", "the", "mutants", ",", "we", "injected", "morpholino", "antisense", "oligonucleotides", "(", "MO", ")", "targeted", "against", "the", "predicted", "initiation", "codon", "of", "Su(fu", ")", "(", "Figure", "5", ")", "." ]

[ 10, 16, 6, 8, 14, 6, 8, 1, 8, 1, 12, 13, 3, 0, 10, 16, 6, 8, 13, 11, 16, 8, 0, 8, 13, 12, 13, 16, 1, 6, 16, 8, 8, 1, 12, 13, 13, 12, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "To", "visualize", "the", "site", "differences", "and", "disorder", "effects", "in", "the", "SRPBS", "multidisorder", "dataset", "while", "maintaining", "its", "quantitative", "properties", ",", "we", "first", "performed", "an", "unsupervised", "dimension", "reduction", "of", "the", "raw", "rs-fcMRI", "data", "using", "a", "principal", "component", "analysis", "(", "PCA", ")", ".", "All", "participant", "data", "in", "the", "SRPBS", "multidisorder", "dataset", "were", "plotted", "on", "two", "axes", "consisting", "of", "the", "first", "two", "principal", "components", "(", "PCs", ")", "(", "Fig", "6A", ",", "small", ",", "light", "-", "colored", "symbols", ")", "." ]

[ 10, 16, 6, 8, 8, 5, 8, 8, 1, 6, 12, 0, 8, 14, 16, 11, 0, 8, 13, 11, 0, 16, 6, 0, 8, 8, 1, 6, 0, 12, 8, 16, 6, 0, 8, 8, 13, 12, 13, 13, 6, 8, 8, 1, 6, 12, 0, 8, 3, 16, 1, 9, 8, 16, 1, 6, 0, 9, 0, 8, 13, 12, 13, 13, 8, 9, 13, 0, 13, 2, 13, 0, 8, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Resting", "-", "state", "(", "RS", ")", "functional", "connectivity", "magnetic", "resonance", "imaging", "(", "fcMRI", ")", "is", "a", "powerful", "tool", "for", "elucidating", "the", "areas", "of", "the", "brain", "involved", "in", "cLBP", "perception", "and", "modulation,[1–3", "]", "as", "it", "facilitates", "study", "of", "both", "local", "and", "diffuse", "functional", "properties", "in", "the", "undisturbed", "state", "of", "chronic", "pain", "and", "because", "RS", "networks", "(", "RSNs", ")", "are", "an", "intrinsic", "property", "of", "the", "brain", "found", "across", "various", "behavioral", "and", "physiological", "states.[1", ",", "4", "]", "Human", "brain", "imaging", "studies", "have", "identified", "potential", "anatomical", "and", "functional", "biomarkers", "that", "differentiate", "cLBP", "patients", "from", "healthy", "subjects.[5", "]", "Chronification", "of", "LBP", "has", "been", "associated", "with", "alterations", "in", "brain", "anatomy", "and", "function", ",", "including", "a", "shift", "in", "activity", "from", "brain", "regions", "involved", "in", "acute", "pain", "to", "more", "emotion", "or", "reward", "circuitry.[1–3", ",", "5", "]", "The", "reported", "changes", "can", "depend", "upon", "1", ")", "the", "population", "of", "chronic", "pain", "patients", "being", "studied", "[", "1", ",", "6", "]", "and", "2", ")", "the", "duration", "of", "pain", "that", "the", "patients", "have", "endured.[1", ",", "5", ",", "7", "]", "Some", "of", "these", "structural", "and", "functional", "changes", "that", "occur", "with", "chronification", "of", "pain", "may", "be", "reversible", "with", "successful", "treatment.[8–11", "]" ]

[ 16, 13, 8, 13, 12, 13, 0, 8, 0, 8, 8, 13, 12, 13, 3, 6, 0, 8, 1, 16, 6, 8, 1, 6, 8, 16, 1, 12, 8, 5, 8, 13, 14, 11, 16, 8, 1, 5, 0, 5, 0, 0, 8, 1, 6, 0, 8, 1, 0, 8, 5, 14, 12, 8, 13, 12, 13, 3, 6, 0, 8, 1, 6, 8, 16, 1, 0, 0, 5, 0, 8, 13, 17, 13, 0, 8, 8, 8, 3, 16, 0, 0, 5, 0, 8, 11, 16, 12, 8, 1, 0, 8, 13, 8, 1, 12, 3, 3, 16, 1, 8, 1, 8, 8, 5, 8, 13, 16, 6, 8, 1, 8, 1, 8, 8, 16, 1, 0, 8, 1, 0, 8, 5, 8, 8, 13, 17, 13, 6, 16, 8, 3, 16, 14, 17, 13, 6, 8, 1, 0, 8, 8, 3, 16, 17, 17, 13, 17, 13, 5, 17, 13, 6, 8, 1, 8, 11, 6, 8, 3, 16, 13, 17, 13, 17, 13, 11, 1, 6, 0, 5, 0, 8, 11, 16, 1, 8, 1, 8, 3, 3, 0, 1, 0, 8, 13 ]

[ 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "recent", "years", ",", "elevated", "circulating", "ATX", "has", "been", "documented", "in", "patients", "with", "other", "liver", "diseases", "including", "chronic", "hepatitis", "C", "virus", "(", "HCV", ")", "infection", ",", "HCV", "-", "associated", "fibrosis", ",", "and", "cirrhosis", "[", "7", ",", "11", ",", "12", "]", "." ]

[ 1, 0, 8, 13, 0, 16, 12, 3, 3, 16, 1, 8, 1, 0, 8, 8, 16, 0, 8, 12, 8, 13, 12, 13, 8, 13, 12, 13, 16, 8, 13, 5, 8, 17, 9, 13, 9, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "CM", "=", "cranial", "metastasis", ";", "CT", "=", "chemotherapy", ";", "n", "=", "number", "of", "patients", ";", "OS", "=", "overall", "survival", ";", "pts", "=", "patients", "." ]

[ 12, 13, 0, 8, 13, 12, 13, 8, 13, 8, 13, 8, 1, 8, 13, 12, 13, 0, 8, 13, 8, 13, 8, 13 ]

[ 1, 0, 3, 4, 0, 1, 0, 3, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 0, 0, 0, 0, 0 ]

[ "TBE", "was", "identified", "using", "a", "common", "clinical", "definition", "of", "meningitis", "confirmed", "by", "the", "presence", "of", "anti", "-", "TBEV", "IgM", "antibodies", "in", "the", "serum", "and", "CSF", "as", "well", "as", "pleocytosis", "in", "the", "CSF", ".", "Clinical", "TBE", "presentations", "[", "11", "]", "were", "defined", "as", "follows", ":", "“", "pure", "meningitis", "”", "(", "meningitis", ")", ",", "without", "focal", "neurological", "symptoms", ";", "meningoencephalitis", "(", "ME", ")", ",", "meningitis", "plus", "focal", "neurological", "symptoms", "and/or", "disturbance", "of", "consciousness", "and/or", "higher", "-", "order", "brain", "dysfunction", ";", "or", "meningoencephaloradiculitis", "(", "MER", ")", ",", "ME", "plus", "clinical", "signs", "of", "alpha", "-", "motor", "neuron", "injury", "(", "AMNI", ")", ".", "All", "patients", "were", "examined", "at", "admission", "and", "followed", "up", "after", "12", "months", "at", "the", "earliest", "with", "a", "clinical", "assessment", "and", "by", "recording", "modified", "RANKIN", "scale", "(", "mRS)[12", "]", "." ]

[ 12, 3, 16, 16, 6, 0, 0, 8, 1, 8, 16, 1, 6, 8, 1, 0, 13, 12, 8, 8, 1, 6, 8, 5, 12, 1, 2, 1, 8, 1, 6, 12, 13, 0, 12, 8, 17, 17, 13, 3, 16, 1, 16, 13, 13, 0, 8, 13, 13, 8, 13, 13, 1, 0, 0, 8, 13, 8, 13, 12, 13, 13, 8, 5, 0, 0, 8, 5, 8, 1, 8, 5, 0, 13, 8, 8, 8, 13, 5, 8, 13, 12, 13, 13, 12, 5, 0, 8, 1, 0, 13, 0, 8, 8, 13, 12, 13, 13, 6, 8, 3, 16, 1, 8, 5, 16, 1, 1, 9, 8, 1, 6, 0, 1, 6, 0, 8, 5, 1, 16, 16, 12, 8, 13, 12, 13, 13 ]

[ 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 1, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0 ]

[ "AC", ",", "auditory", "cortex", ";", "ACC", ",", "anterior", "cingulate", "cortex", ";", "CTR", ",", "control", "condition", ";", "DEV", ",", "deviant", "condition", ";", "IC", ",", "inferior", "colliculus", ";", "IL", ",", "infralimbic", "cortex", ";", "iMM", ",", "index", "of", "neuronal", "mismatch", ";", "iPE", ",", "index", "of", "prediction", "error", ";", "iRS", ",", "index", "of", "repetition", "suppression", ";", "MGB", ",", "medial", "geniculate", "body", ";", "M2", ",", "secondary", "motor", "cortex", ";", "PL", ",", "prelimbic", "cortex", ";", "STD", ",", "standard", "condition", "." ]

[ 12, 13, 0, 8, 13, 12, 13, 0, 0, 8, 13, 12, 13, 8, 8, 13, 12, 13, 0, 8, 13, 12, 13, 0, 8, 13, 12, 13, 0, 8, 13, 12, 13, 8, 1, 0, 8, 13, 12, 13, 8, 1, 8, 8, 13, 12, 13, 8, 1, 8, 8, 13, 12, 13, 0, 0, 8, 13, 12, 13, 0, 8, 8, 13, 12, 13, 0, 8, 13, 12, 13, 0, 8, 13 ]

[ 1, 0, 3, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0 ]

[ "CCR5", ",", "C", "-", "C", "motif", "chemokine", "receptor", "5", ";", "GFP", ",", "green", "fluorescent", "protein", "." ]

[ 12, 13, 8, 13, 8, 8, 8, 8, 9, 13, 12, 13, 0, 0, 8, 13 ]

[ 1, 0, 3, 4, 4, 4, 4, 4, 4, 0, 1, 0, 3, 4, 4, 0 ]

[ "Postpartum", "hemorrhage", "(", "PPH", ")", "occurs", "in", "approximately", "3–5", "%", "of", "obstetric", "patients", "[", "1", "]", "." ]

[ 0, 8, 13, 12, 13, 16, 1, 2, 9, 8, 1, 0, 8, 13, 9, 13, 13 ]

[ 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "DD", ",", "diversity", "-", "dependent", ";", "MLE", ",", "maximum", "likelihood", "estimate", ";", "PGLS", ",", "phylogenetic", "generalized", "least", "squares", "." ]

[ 12, 13, 8, 13, 0, 13, 12, 13, 0, 8, 8, 13, 12, 13, 0, 16, 0, 8, 13 ]

[ 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 4, 0 ]

[ "Here", ",", "we", "extend", "this", "analysis", "to", "18", "y", "of", "follow", "-", "up", ",", "include", "data", "from", "the", "Nurses", "'", "Health", "Study", "(", "NHS", ")", "II", ",", "use", "the", "quantitative", "whole", "grain", "variable", ",", "and", "evaluate", "the", "role", "of", "the", "bran", "and", "germ", "constituents", "separately", "." ]

[ 2, 13, 11, 16, 6, 8, 1, 9, 8, 1, 8, 13, 8, 13, 16, 8, 1, 6, 12, 10, 12, 12, 13, 12, 13, 9, 13, 16, 6, 0, 0, 8, 8, 13, 5, 16, 6, 8, 1, 6, 8, 5, 8, 8, 2, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Like", "other", "drugs", ",", "ALLINIs", "seem", "to", "target", "also", "the", "HIV-1", "integrase", "(", "IN", ")", ",", "which", "is", "crucial", "for", "the", "replication", "of", "this", "virus", ",", "but", "instead", "of", "acting", "at", "early", "phases", "of", "HIV", "replication", ",", "they", "interfere", "with", "viral", "particle", "assembly", "and", "maturation", "that", "occur", "at", "late", "stages", "and", "induce", "aggregation", "of", "IN", ".", "Despite", "these", "findings", ",", "the", "structural", "bases", "for", "the", "effects", "are", "still", "unknown", "." ]

[ 1, 0, 8, 13, 12, 16, 10, 16, 2, 6, 9, 8, 13, 12, 13, 13, 11, 3, 0, 1, 6, 8, 1, 6, 8, 13, 5, 2, 1, 16, 1, 0, 8, 1, 12, 8, 13, 11, 16, 1, 0, 8, 8, 5, 8, 11, 16, 1, 0, 8, 5, 16, 8, 1, 12, 13, 14, 6, 8, 13, 6, 0, 8, 1, 6, 8, 3, 2, 0, 13 ]

[ 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BLSA", "participants", "underwent", "11C", "-", "Pittsburgh", "compound", "-", "B", "(", "-NIPiB", ")", "PET", "scans", "to", "assess", "brain", "amyloid", "-", "β", "burden", "." ]

[ 12, 8, 16, 12, 13, 12, 12, 13, 12, 13, 12, 13, 12, 8, 10, 16, 8, 8, 13, 13, 8, 13 ]

[ 1, 0, 0, 3, 4, 4, 4, 4, 4, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Consistent", "with", "this", "proposition", ",", "reporter", "assays", "with", "p21", "promoter", "-", "driven", "luciferase", "in", "HCT116", "cells", "indicated", "that", ",", "under", "both", "normal", "and", "stressed", "conditions", ",", "JMJD6", "down", "-", "regulates", "the", "expression", "of", "the", "p53", "target", "gene", "at", "the", "transcriptional", "level", "(", "Figure", "3C", ")", ".", "In", "addition", ",", "although", "JMJD6", "was", "described", "as", "a", "histone", "demethylase", "for", "H3R2", "and", "H4R3", "[", "4],[46", "]", ",", "measurements", "of", "the", "levels", "of", "dimethylated", "(", "me2", ")", "H3R2", "and", "H4R3", "at", "p21", "promoter", "in", "HCT116", "cells", "by", "quantitative", "chromatin", "immunoprecipitation", "(", "qChIP", ")", "detected", "no", "significant", "changes", "in", "H3R2me2", "and", "H4R3me2", "after", "JMJD6", "depletion", "(", "Figure", "3D", ")", ".", "The", "recruitment", "of", "JMJD6", "and", "p53", "on", "p21", "promoter", "was", "also", "tested", "by", "qChIP", "assays", "in", "HCT116", "cells", "." ]

[ 0, 1, 6, 8, 13, 8, 8, 1, 8, 8, 13, 16, 8, 1, 12, 8, 16, 14, 13, 1, 5, 0, 5, 0, 8, 13, 12, 2, 13, 16, 6, 8, 1, 6, 8, 8, 8, 1, 6, 0, 8, 13, 12, 9, 13, 13, 1, 8, 13, 14, 12, 3, 16, 1, 6, 8, 8, 1, 12, 5, 12, 17, 9, 13, 13, 8, 1, 6, 8, 1, 16, 13, 8, 13, 12, 5, 12, 1, 8, 8, 1, 12, 8, 1, 0, 8, 8, 13, 12, 13, 16, 6, 0, 8, 1, 8, 5, 8, 1, 12, 8, 13, 12, 9, 13, 13, 6, 8, 1, 12, 5, 8, 1, 8, 8, 3, 2, 16, 1, 12, 8, 1, 12, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0 ]

[ "Statistical", "significance", "of", "the", "expression", "data", "was", "determined", "using", "fold", "change", "and", "local", "pooled", "error", "(", "LPE", ")", "test", "in", "which", "the", "null", "hypothesis", "was", "that", "no", "difference", "exists", "between", "the", "groups", "." ]

[ 0, 8, 1, 6, 8, 8, 3, 16, 16, 8, 8, 5, 0, 0, 8, 13, 12, 13, 8, 1, 11, 6, 0, 8, 3, 14, 6, 8, 16, 1, 6, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "They", "observed", "that", "almost", "65,000", "African", "-", "born", "émigré", "physicians", "and", "nearly", "70,000", "African", "-", "born", "émigré", "professional", "nurses", "were", "practicing", "in", "eight", "Organization", "of", "Economic", "Cooperation", "and", "Development", "(", "OECD", ")", "high", "-", "income", "countries", "and", "in", "South", "Africa", "." ]

[ 11, 16, 14, 2, 9, 12, 13, 16, 0, 8, 5, 2, 9, 12, 13, 16, 0, 0, 8, 3, 16, 1, 9, 12, 1, 12, 12, 5, 12, 13, 12, 13, 0, 13, 8, 8, 5, 1, 12, 12, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "World", "Health", "Organization", "(", "WHO", ")", "clinical", "stage", "III", "and", "IV", ",", "CD4", "counts", "less", "than", "50", "cells", "/", "μl", ",", "not", "taking", "Cotrimoxazole", "Prophylaxis", "Treatment", "at", "the", "baseline", "were", "the", "identified", "predictors", "for", "early", "mortality", "after", "ART", "initiation", "[", "14", ",", "23", "]", "." ]

[ 12, 12, 12, 13, 12, 13, 0, 8, 9, 5, 9, 13, 12, 8, 0, 1, 9, 8, 15, 8, 13, 10, 16, 12, 12, 12, 1, 6, 8, 3, 6, 16, 8, 1, 0, 8, 1, 12, 8, 13, 9, 13, 9, 13, 13 ]

[ 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0 ]

[ "AB", ",", "antibody", ";", "ACK", ",", "ammonium", "-", "chloride", "-", "potassium", ";", "BSA", ",", "bovine", "serum", "albumin", ";", "CSL", ",", "CBF1", "/", "Suppressor", "of", "Hairless", "/", "LAG-1", ";", "DSS", ",", "decxtran", "sodium", "sulfate", ";", "EMSA", ",", "electrophoretic", "mobility", "shift", "assay", ";", "FBS", ",", "fetal", "bovine", "serum", ";", "HDM", ",", "house", "dust", "mite", ";", "HRP", ",", "horseradish", "peroxidase", ";", "IgG", ",", "immunoglobulin", "G", ";", "IgM", ",", "immunoglobulin", "M", ";", "LPS", ",", "lipopolysaccharide", ";", "mAb", ",", "monoclonal", "antibody", ";", "N1", ",", "Notch1", ";", "N1ΔE", ",", "constitutive", "active", "Notch1", "lacking", "extracellular", "domain", ";", "N2", ",", "Notch2", ";", "qPCR", ",", "quantitative", "PCR", ";", "RA", ",", "Arg", "-", "Ala", "substitution", ";", "RPMI", ",", "Roswell", "Park", "Memorial", "Institute", ";", "sgRNA", ",", "short", "guide", "RNA", ";", "SPS", ",", "sequence", "-", "paired", "site", ";", "TMB", ",", "3,3′,5,5′-Tetramethylbenzidine", ";", "UNLB", ",", "unlabeled", "." ]

[ 12, 13, 8, 13, 12, 13, 8, 13, 8, 13, 8, 13, 12, 13, 0, 8, 8, 13, 12, 13, 12, 15, 12, 1, 12, 15, 12, 13, 12, 13, 8, 8, 8, 13, 12, 13, 0, 8, 8, 8, 13, 12, 13, 0, 0, 8, 13, 12, 13, 8, 8, 8, 13, 12, 13, 8, 8, 13, 12, 13, 8, 8, 13, 12, 13, 8, 8, 13, 12, 13, 8, 13, 8, 13, 0, 8, 13, 12, 13, 8, 13, 12, 13, 0, 0, 8, 16, 0, 8, 13, 12, 13, 12, 13, 8, 13, 0, 8, 13, 12, 13, 8, 13, 8, 8, 13, 12, 13, 12, 12, 12, 12, 13, 8, 13, 0, 8, 8, 13, 12, 13, 8, 13, 16, 8, 13, 12, 13, 8, 13, 12, 13, 16, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 0, 1, 0, 3, 4, 0, 1, 0, 3, 0, 0, 0, 0, 0, 0, 1, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 1, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Labels", "describe", "vaccines", "received", "and", "number", "of", "doses", "(", "i.e.", ",", "bOPV×2", "and", "IPV×1", ":", "two", "doses", "of", "bOPV", "and", "one", "dose", "of", "IPV", ")", ".", "(", "A", ")", "Shedding", "duration", "after", "OPV", "challenge", ":", "shedding", "duration", "survival", "curves", "from", "aggregated", "trial", "data", "(", "solid", "lines", ")", "and", "maximum", "likelihood", "model", "fit", "(", "dashed", ")", "for", "each", "immunization", "schedule", "and", "poliovirus", "type", ".", "(", "Infection", "with", "Sabin", "1", ",", "blue", ";", "Sabin", "2", ",", "red", ";", "Sabin", "3", ",", "orange", ";", "WPV", ",", "black", ")", ".", "(", "B", ")", "Median", "shedding", "durations", "after", "infection", "because", "of", "OPV", "challenge", "or", "WPV", "transmission", "estimated", "from", "model", "fits", "in", "panels", "A", "and", "(", "C", ")", ",", "corresponding", "pre", "-", "challenge", "homotypic", "OPV", "-", "equivalent", "antibody", "titers", "(", "see", ",", "also", ",", "S1", "Text", "Fig", "A", ",", "and", "an", "interactive", "visualization", "of", "shedding", "duration", "data", "is", "available", "at", "https://famulare.github.io/cessationStability/", ")", ".", "bOPV", ",", "bivalent", "type", "1", "and", "3", "OPV", "OPV", ";", "IPV", ",", "inactivated", "polio", "vaccine", ";", "OPV", ",", "oral", "polio", "vaccine", ";", "WPV", ",", "wild", "poliovirus", "." ]

[ 8, 16, 8, 16, 5, 8, 1, 8, 13, 17, 13, 12, 5, 12, 13, 9, 8, 1, 12, 5, 9, 8, 1, 12, 13, 13, 13, 12, 13, 8, 8, 1, 12, 0, 13, 16, 8, 8, 8, 1, 16, 8, 8, 13, 0, 8, 13, 5, 0, 8, 8, 8, 13, 16, 13, 1, 6, 8, 8, 5, 8, 8, 13, 13, 8, 1, 12, 9, 13, 0, 13, 12, 9, 13, 0, 13, 12, 9, 13, 8, 13, 12, 13, 8, 13, 13, 13, 17, 13, 0, 16, 8, 1, 8, 14, 1, 12, 0, 5, 12, 8, 16, 1, 8, 8, 1, 8, 12, 5, 13, 8, 13, 13, 0, 0, 13, 0, 0, 12, 13, 0, 8, 8, 13, 16, 13, 2, 13, 8, 8, 12, 12, 13, 5, 6, 0, 8, 1, 16, 8, 8, 3, 0, 1, 17, 13, 13, 12, 13, 0, 8, 9, 5, 9, 12, 12, 13, 12, 13, 0, 8, 8, 13, 12, 13, 0, 8, 8, 13, 12, 13, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4, 4, 4, 4, 4, 1, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 4, 0, 1, 0, 3, 4, 0 ]

[ "f", "SOFA", ";", "Sequential", "Organ", "Failure", "Assessment", "score", "(", "SOFAscore", ")", "." ]

[ 17, 12, 13, 0, 12, 12, 12, 8, 13, 12, 13, 13 ]

[ 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0 ]

[ "First", "-", "line", "ART", "drug", "regimens", "were", "started", "within", "2", "wk", "of", "study", "enrollment", "and", "included", "two", "nucleoside", "reverse", "transcriptase", "inhibitors", "(", "3TC", ",", "plus", "either", "stavudine", "[", "d4", "]", "or", "TZDV", ")", ",", "and", "one", "NNRTI", "(", "either", "NVP", "or", "efavirenz", "[", "EFV", "]", ")", "[", "18", "]", "." ]

[ 0, 13, 8, 12, 8, 8, 3, 16, 1, 9, 8, 1, 8, 8, 5, 16, 9, 8, 0, 8, 8, 13, 12, 13, 5, 5, 8, 13, 12, 13, 5, 12, 13, 13, 5, 9, 12, 13, 5, 12, 5, 8, 13, 12, 13, 13, 13, 9, 13, 13 ]

[ 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 3, 0, 1, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 1, 0, 3, 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "Larval", "fish", "with", "bioluminescence", "above", "background", "(", "more", "than", "100", "counts", "per", "second", "per", "[", "cps", "]", ")", "were", "raised", "as", "transgenic", "F1", "fish", "." ]

[ 0, 8, 1, 8, 1, 8, 13, 0, 1, 9, 8, 1, 8, 12, 13, 12, 13, 13, 3, 16, 1, 0, 12, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Noonan", "and", "colleagues", "[", "1", "]", "estimated", "an", "older", "divergence", "time", "(", "i.e.", ",", "time", "to", "the", "most", "recent", "common", "ancestor", ")", "between", "human", "and", "Neanderthal", "sequences", "(", "∼706,000", "y", "ago", ")", ",", "and", "a", "0", "%", "contribution", "of", "Neanderthal", "DNA", "(", "95", "%", "confidence", "interval", "[", "CI", "]", ":", "0%–20", "%", ")", "to", "the", "modern", "European", "gene", "pool", "." ]

[ 12, 5, 8, 13, 17, 13, 16, 6, 0, 8, 8, 13, 17, 13, 8, 1, 6, 2, 0, 0, 8, 13, 1, 0, 5, 0, 8, 13, 9, 8, 2, 13, 13, 5, 6, 9, 8, 8, 1, 0, 8, 13, 9, 8, 8, 8, 13, 12, 13, 13, 9, 8, 13, 1, 6, 0, 0, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "IVW", ",", "inverse", "-", "variance", "weighted", ";", "MR", ",", "Mendelian", "randomisation", "." ]

[ 12, 13, 0, 13, 8, 16, 13, 12, 13, 0, 8, 13 ]

[ 1, 0, 3, 4, 4, 4, 0, 1, 0, 3, 4, 0 ]

[ "Proliferating", "cell", "nuclear", "antigen", "(", "PCNA", ")", "plays", "an", "essential", "role", "in", "DNA", "replication", "and", "repair", "by", "interacting", "with", "a", "large", "number", "of", "proteins", "involved", "in", "these", "processes", "." ]

[ 16, 8, 0, 8, 13, 12, 13, 16, 6, 0, 8, 1, 8, 8, 5, 8, 1, 16, 1, 6, 0, 8, 1, 8, 16, 1, 6, 8, 13 ]

[ 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Western", "blot", "analysis", "showed", "a", "reduction", "of", "lamin", "A", "/", "C", "protein", "in", "bone", "marrow", "stromal", "cells", "(", "BMSCs", ")", ",", "but", "not", "bone", "marrow", "macrophages", "/", "monocytes", "(", "BMMs", ")", ",", "derived", "from", "LmnaOcn", "-cko", "mice", "(", "S1B", "Fig", ")", "." ]

[ 0, 8, 8, 16, 6, 8, 1, 8, 8, 15, 8, 8, 1, 8, 8, 0, 8, 13, 12, 13, 13, 5, 10, 8, 8, 8, 15, 8, 13, 12, 13, 13, 16, 1, 12, 12, 8, 13, 12, 12, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0 ]

[ "We", "estimated", "incidence", "rate", "ratios", "and", "95", "%", "confidence", "intervals", "(", "95%CI", ")", "using", "Poisson", "regression", ",", "comparing", "infants", "born", "to", "A", "/", "H1N1", "-", "vaccinated", "women", "(", "vaccine", "-", "exposed", "infants", ")", "with", "unexposed", "infants", ",", "adjusted", "for", "confounding", "using", "high", "-", "dimensional", "propensity", "scores", "." ]

[ 11, 16, 8, 8, 8, 5, 9, 8, 8, 8, 13, 12, 13, 16, 12, 8, 13, 16, 8, 16, 1, 8, 15, 8, 13, 16, 8, 13, 8, 13, 16, 8, 13, 1, 0, 8, 13, 16, 1, 16, 16, 0, 13, 0, 8, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "1", ")", "Reviewer", "#", "1", ":", "The", "authors", "performed", "a", "genome", "-", "wide", "association", "study", "(", "GWAS", ")", "on", "abdominal", "aortic", "aneurysms", "(", "AAA", ")", "and", "thoracic", "aortic", "aneurysms", "(", "TAA", ")", "using", "data", "from", "the", "UK", "Biobank", "." ]

[ 9, 13, 8, 8, 9, 13, 6, 8, 16, 6, 8, 13, 0, 8, 8, 13, 12, 13, 1, 0, 0, 8, 13, 12, 13, 5, 0, 0, 8, 13, 12, 13, 16, 8, 1, 6, 12, 12, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 3, 4, 4, 0, 1, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0 ]

[ "Prostate", "cancer", "(", "PCa", ")", "is", "one", "amongst", "the", "most", "common", "cancersin", "western", "men", "." ]

[ 0, 8, 13, 12, 13, 3, 9, 1, 6, 2, 0, 1, 0, 8, 13 ]

[ 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "the", "crystal", "structures", ",", "the", "guanidino", "headgroup", "of", "the", "−2", "Arg", "residue", "in", "the", "peptide", "occupies", "an", "acidic", "pocket", "comprising", "two", "acidic", "residues", "(", "Asp444", "and", "Glu507", ")", "and", "a", "polar", "Ser", "residue", "(", "Ser443", ")", "(", "Fig", "3A", ")", ".", "This", "pocket", "has", "previously", "been", "implicated", "in", "mediating", "specificity", "at", "the", "−2", "position", "for", "PAKs", "and", "other", "kinases", ",", "including", "cAMP", "-", "dependent", "protein", "kinase", "(", "PKA", ")", "[", "45", "]", "." ]

[ 1, 6, 8, 8, 13, 6, 8, 8, 1, 6, 9, 8, 8, 1, 6, 8, 16, 6, 0, 8, 16, 9, 0, 8, 13, 8, 5, 12, 13, 5, 6, 0, 12, 8, 13, 8, 13, 13, 8, 9, 13, 13, 6, 8, 3, 2, 3, 16, 1, 16, 8, 1, 6, 9, 8, 1, 12, 5, 0, 8, 13, 16, 8, 13, 0, 8, 8, 13, 12, 13, 13, 9, 13, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0 ]

[ "The", "difference", "in", "the", "prevalence", "of", "T2DM", "and", "hypertension", "between", "NAFLD", "patients", "and", "the", "general", "population", "was", "evaluated", "using", "the", "standardized", "incidence", "ratio", "(", "SIR", ")", "and", "95", "%", "CI", "based", "on", "the", "2011", "statistics", "database", "published", "by", "Kanagawa", "Prefecture", "[", "25", "]", ",", "which", "was", "the", "place", "of", "residence", "of", "almost", "all", "patients", "." ]

[ 6, 8, 1, 6, 8, 1, 12, 5, 8, 1, 12, 8, 5, 6, 0, 8, 3, 16, 16, 6, 0, 8, 8, 13, 12, 13, 5, 9, 8, 12, 16, 1, 6, 9, 8, 8, 16, 1, 12, 12, 13, 9, 13, 13, 11, 3, 6, 8, 1, 8, 1, 2, 11, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "a", "previous", "non", "-", "targeted", "metabolomics", "study", "of", "common", "marmosets", "(", "Callithrix", "jacchus", ")", ",", "Rhesus", "macaques", ",", "humans", ",", "and", "four", "non", "-", "primate", "mammalian", "species", ",", "we", "found", "that", "essential", "amino", "acids", "(", "AA", ")", "and", "other", "central", "metabolites", "had", "interspecies", "variation", "similar", "to", "intraspecies", "variation", "while", "non", "-", "essential", "AA", ",", "environmental", "chemicals", "and", "catabolic", "waste", "products", "had", "greater", "interspecies", "variation", "." ]

[ 1, 6, 0, 0, 0, 0, 8, 8, 1, 0, 8, 13, 12, 8, 13, 13, 12, 8, 13, 8, 13, 5, 9, 0, 0, 0, 0, 8, 13, 11, 16, 14, 0, 0, 8, 13, 12, 13, 5, 0, 0, 8, 16, 0, 8, 0, 1, 0, 8, 14, 0, 0, 0, 12, 13, 0, 8, 5, 0, 8, 8, 16, 0, 0, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "N", ":", "lymph", "node", ";", "M", ":", "distant", "metastases", ";", "HG", ":", "Histological", "Grade" ]

[ 8, 13, 8, 8, 13, 8, 13, 0, 8, 13, 12, 13, 0, 8 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 4 ]

[ "US", "data", "from", "NIS", "and", "the", "National", "Hospital", "Discharge", "Survey", "(", "NHDS", ")", "estimated", "blood", "stream", "infection", "at", "0.02", "%", "[", "65", "]", "and", "0.07", "%", "[", "75", "]", "." ]

[ 12, 8, 1, 12, 5, 6, 12, 12, 12, 12, 13, 12, 13, 16, 8, 8, 8, 1, 9, 8, 13, 9, 13, 5, 9, 8, 13, 9, 13, 13 ]

[ 0, 0, 0, 1, 0, 0, 3, 4, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "CO2", "-", "induced", "stomatal", "closure", "reduces", "water", "loss", ";", "hence", ",", "it", "can", "directly", "modify", "plant", "water", "use", "efficiency", "(", "WUE)—carbon", "assimilated", "through", "photosynthesis", "versus", "water", "lost", "through", "stomata", "." ]

[ 8, 13, 16, 0, 8, 16, 8, 8, 13, 2, 13, 11, 3, 2, 16, 8, 8, 8, 8, 13, 12, 16, 1, 8, 1, 8, 16, 1, 8, 13 ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]