Datasets:

Stardrums

/

pico-breast-cancer

like 2

[ "Levofloxacin", "for", "prophylaxis", "in", "breast", "cancer", "surgery", "compared", "with", "ofloxacin", ".", "We", "found", "that", "once", "-", "daily", "use", "of", "ofloxacin", "is", "beneficial", "from", "the", "standpoints", "of", "economy", "and", "patient", "compliance", ".", "Levofloxacin", ",", "has", "twice", "the", "antimicrobial", "activity", "and", "same", "toxicity", "of", "ofloxacin", ".", "We", "investigated", "the", "clinical", "usefulness", "of", "levofloxacin", "compared", "with", "ofloxacin", "in", "breast", "surgery", ".", "Between", "July", ",", "1996", "and", "April", ",", "1999", ",", "199", "consecutive", "patients", "hospitalized", "in", "our", "department", "for", "treatment", "of", "breast", "cancer", "were", "enrolled", "in", "this", "study", "with", "their", "informed", "consent", "and", "181", "patients", "were", "evaluated", ".", "Four", "(", "4", "%", ")", "of", "the", "99", "patients", "in", "the", "levofloxacin", "group", "had", "wound", "infections", ",", "as", "did", "5", "(", "6", "%", ")", "of", "the", "82", "patients", "in", "the", "ofloxacin", "group", ".", "The", "median", "times", "needed", "for", "wound", "care", ",", "with", "25", "th", "and", "75", "th", "percentiles", ",", "were", "13", "[", "9", ",", "16", "]", "days", "in", "the", "levofloxacin", "group", "and", "11", "[", "9", ",", "16", "]", "days", "in", "the", "ofloxacin", "group", ".", "From", "infected", "wound", "three", "strains", "of", "Staphylococcus", "aureus", "were", "detected", "from", "the", "levofloxacin", "group", "and", "two", "strains", "were", "from", "ofloxacin", "group", ",", "but", "no", "methicillin", "-", "resistant", "strains", "were", "isolated", ".", "Multiple", "regression", "analysis", "showed", "that", "only", "wound", "dehiscence", "was", "a", "significant", "factor", "in", "the", "occurrence", "of", "wound", "infection", "and", "the", "period", "of", "wound", "care", ".", "No", "signs", "or", "symptoms", "suggesting", "levofloxacin", "or", "ofloxacin", "toxicity", "were", "observed", ".", "Laboratory", "test", "changes", "before", "and", "after", "treatment", "were", "similar", "in", "the", "two", "groups", ".", "It", "appears", "that", "levofloxacin", "is", "not", "superior", "to", "ofloxacin", "in", "prophylactic", "efficacy", "for", "postoperative", "wound", "infection", "after", "breast", "surgery", "." ]

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[ "Effects", "of", "hydrochlorothiazide", "on", "drainage", "volume", "and", "seroma", "formation", "in", "deep", "inferior", "epigastric", "perforator", "flap", "breast", "reconstruction", ":", "Randomized", "controlled", "trial", ".", "Seroma", "is", "a", "recognized", "complication", "encountered", "at", "the", "reconstructed", "breast", "and", "donor", "site", "after", "abdominal", "-", "based", "breast", "reconstruction", ".", "Seroma", "is", "caused", "by", "lymphatic", "channel", "disruption", "and", "the", "formation", "of", "a", "large", "space", "between", "the", "deep", "fascia", "during", "flap", "elevation", ".", "Surgical", "techniques", "to", "preserve", "the", "lymphatics", "and", "secure", "the", "closure", "of", "the", "donor", "site", "can", "reduce", "seroma", "formation", ".", "This", "study", "investigated", "the", "safety", "and", "effectiveness", "of", "the", "diuretic", "hydrochlorothiazide", "at", "reducing", "interstitial", "fluid", "accumulation", "and", "seroma", "formation", "during", "deep", "inferior", "epigastric", "perforator", "(", "DIEP", ")", "flap", "breast", "reconstruction", ".", "Sixty", "patients", "with", "breast", "cancer", "who", "underwent", "skin-", "or", "nipple", "-", "sparing", "mastectomy", "and", "DIEP", "flap", "reconstruction", "were", "enrolled", "between", "August", "2016", "and", "June", "2017", ".", "The", "patients", "were", "randomly", "assigned", "to", "receive", "either", "25", "mg", "per", "day", "of", "hydrochlorothiazide", "from", "the", "second", "to", "the", "twentieth", "day", "after", "surgery", "(", "treatment", ")", "or", "no", "diuretic", "(", "control", ")", ".", "The", "clinicopathological", "characteristics", ",", "drainage", "time", ",", "and", "drainage", "volume", "were", "statistically", "compared", "between", "the", "two", "groups", ".", "The", "average", "total", "drainage", "volume", "at", "the", "donor", "site", "was", "291", "mL", "in", "the", "treatment", "group", "and", "434", "mL", "in", "the", "control", "group", "(", "p", "=", "0.003", ")", ".", "The", "differences", "in", "body", "mass", "index", "and", "flap", "weight", "between", "the", "two", "groups", "were", "not", "statistically", "significant", "(", "p", "=", "0.879", "and", "p", "=", "0.963", ",", "respectively", ")", ".", "No", "hypotension", "or", "electrolyte", "imbalance", "was", "noted", "during", "the", "follow", "-", "up", ".", "Intake", "of", "25", "mg", "per", "day", "of", "hydrochlorothiazide", "tablets", "effectively", "reduced", "the", "total", "abdominal", "drainage", "volume", "and", "removal", "time", "of", "indwelling", "drains", ".", "However", ",", "the", "adverse", "effects", "should", "be", "further", "investigated", "in", "a", "large", "population", "and", "multiracial", "cohort", "before", "using", "hydrochlorothiazide", "for", "seroma", "prevention", "." ]

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[ "Prophylactic", "use", "of", "levonorgestrel", "-", "releasing", "intrauterine", "system", "in", "women", "with", "breast", "cancer", "treated", "with", "tamoxifen", ":", "a", "randomized", "controlled", "trial", ".", "To", "estimate", "the", "rate", "of", "endometrial", "pathology", "with", "the", "prophylactic", "use", "of", "levonorgestrel", "-", "releasing", "intrauterine", "system", "in", "women", "with", "breast", "cancer", "treated", "with", "tamoxifen", ".", "This", "was", "a", "randomized", "contro", "-", "lled", "trial", "of", "129", "Chinese", "women", "who", "attended", "a", "university", "hospital", "in", "Hong", "Kong", "and", "required", "adjuvant", "tamoxifen", "for", "breast", "cancer", "after", "the", "completion", "of", "postoperative", "radiotherapy", "and", "chemotherapy", ".", "Women", "were", "randomized", "to", "treatment", "(", "prophylactic", "levonorgestrel", "-", "releasing", "intrauterine", "system", "insertion", "before", "the", "commencement", "of", "tamoxifen", ")", "or", "control", "group", ".", "The", "uterine", "cavity", "was", "examined", "by", "hysteroscopy", "and", "endometrial", "sampling", "before", "the", "commencement", "of", "tamoxifen", "and", "at", "12", ",", "24", ",", "45", ",", "and", "60", "months", "afterward", ".", "Any", "endometrial", "polyps", "or", "submucosal", "fibroids", "were", "resected", "through", "hysteroscopy", "at", "each", "assessment", "and", "specimens", "were", "sent", "for", "histologic", "confirmation", ".", "A", "total", "of", "94", "women", "completed", "5", "-year", "follow", "-", "up", ".", "There", "was", "no", "significant", "difference", "in", "the", "occurrence", "of", "submucosal", "fibroids", "(", "1", "[", "1.8", "%", "]", "compared", "with", "2", "[", "3.4", "%", "]", ")", "and", "endometrial", "hyperplasia", "(", "both", "0", ")", "in", "the", "treatment", "and", "control", "groups", ",", "respectively", ".", "Levonorgestrel", "-", "releasing", "intrauterine", "system", "significantly", "reduced", "de", "novo", "endometrial", "polyps", "(", "hazard", "ratio", "0.19", ",", "95", "%", "confidence", "interval", "0.07", "-", "0.48", ")", "over", "the", "course", "of", "5", "years", "on", "an", "intention", "-", "to", "-", "treat", "basis", ".", "There", "was", "no", "statistically", "significant", "increase", "in", "breast", "cancer", "recurrence", "rate", "(", "10", "[", "17.2", "%", "]", "compared", "with", "6", "[", "10.0", "%", "]", ")", "or", "cancer", "-", "related", "deaths", "(", "6", "[", "10.3", "%", "]", "compared", "with", "5", "[", "8.3", "%", "]", ")", "in", "the", "treatment", "group", ",", "but", "the", "study", "was", "underpowered", "in", "this", "regard", ".", "Prophylactic", "levonorgestrel", "-", "releasing", "intrauterine", "system", "prevents", "de", "novo", "endometrial", "polyps", "in", "women", "using", "tamoxifen", ".", "However", ",", "its", "role", "in", "the", "prevention", "of", "endometrial", "hyperplasia", "and", "adenocarcinoma", "as", "well", "as", "its", "effect", "on", "risk", "of", "breast", "cancer", "recurrence", "remain", "uncertain", ".", "Chinese", "Clinical", "Trial", "Registry", ",", "http://www.chictr.org/en/", ",", "ChiCTR", "-", "TRC-", "09000625", ".", "I", "." ]

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[ "Preoperative", "MRI", "and", "surgical", "management", "in", "patients", "with", "nonpalpable", "breast", "cancer", ":", "the", "MONET", "-", "randomised", "controlled", "trial", ".", "We", "evaluated", "whether", "performing", "contrast", "-", "enhanced", "breast", "MRI", "in", "addition", "to", "mammography", "and/or", "ultrasound", "in", "patients", "with", "nonpalpable", "suspicious", "breast", "lesions", "improves", "breast", "cancer", "management", ".", "The", "MONET", "-", "study", "(", "MR", "mammography", "of", "nonpalpable", "breast", "tumours", ")", "is", "a", "randomised", "controlled", "trial", "in", "patients", "with", "a", "nonpalpable", "BIRADS", "3", "-", "5", "lesion", ".", "Patients", "were", "randomly", "assigned", "to", "receive", "routine", "medical", "care", ",", "including", "mammography", ",", "ultrasound", "and", "lesion", "sampling", "by", "large", "core", "needle", "biopsy", "or", "additional", "MRI", "preceding", "biopsy", ".", "Patients", "with", "cancer", "were", "referred", "for", "surgery", ".", "Primary", "end", "-", "point", "was", "the", "rate", "of", "additional", "surgical", "procedures", "(", "re", "-", "excisions", "and", "conversion", "to", "mastectomy", ")", "in", "patients", "with", "a", "nonpalpable", "breast", "cancer", ".", "Four", "hundred", "and", "eighteen", "patients", "were", "randomised", ",", "207", "patients", "were", "allocated", "to", "MRI", ",", "and", "211", "patients", "to", "the", "control", "group", ".", "In", "the", "MRI", "group", "74", "patients", "had", "83", "malignant", "lesions", ",", "compared", "to", "75", "patients", "with", "80", "malignant", "lesions", "in", "the", "control", "group", ".", "The", "primary", "breast", "conserving", "surgery", "(", "BCS", ")", "rate", "was", "similar", "in", "both", "groups", ";", "68", "%", "in", "the", "MRI", "group", "versus", "66", "%", "in", "the", "control", "group", ".", "The", "number", "of", "re", "-", "excisions", "performed", "because", "of", "positive", "resection", "margins", "after", "primary", "BCS", "was", "increased", "in", "the", "MRI", "group", ";", "18", "/", "53", "(", "34", "%", ")", "patients", "in", "the", "MRI", "group", "versus", "6", "/", "50", "(", "12", "%", ")", "in", "the", "control", "group", "(", "p=", "0.008", ")", ".", "The", "number", "of", "conversions", "to", "mastectomy", "did", "not", "differ", "significantly", "between", "groups", ".", "Overall", ",", "the", "rate", "of", "an", "additional", "surgical", "intervention", "(", "BCS", "and", "mastectomy", "combined", ")", "after", "initial", "breast", "conserving", "surgery", "was", "24", "/", "53", "(", "45", "%", ")", "in", "the", "MRI", "group", "versus", "14", "/", "50", "(", "28", "%", ")", "in", "the", "control", "group", "(", "p=", "0.069", ")", ".", "Addition", "of", "MRI", "to", "routine", "clinical", "care", "in", "patients", "with", "nonpalpable", "breast", "cancer", "was", "paradoxically", "associated", "with", "an", "increased", "re", "-", "excision", "rate", ".", "Breast", "MRI", "should", "not", "be", "used", "routinely", "for", "preoperative", "work", "-", "up", "of", "patients", "with", "nonpalpable", "breast", "cancer", "." ]

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[ "[", "Survival", "of", "breast", "cancer", "patients", "treated", "with", "inhibitors", "of", "the", "aromatase", "vs", "tamoxifen", "]", ".", "In", "Mexico", "the", "breast", "cancer", "occupies", "the", "second", "place", "as", "cause", "of", "death", "by", "oncological", "illness", "and", "the", "etiology", "is", "considered", "multifactorial", ".", "The", "systemic", "treatment", "of", "this", "cancer", "is", "necessarily", "after", "the", "surgery", "and", "simultaneously", "when", "radiotherapy", "is", "used", ";", "therefore", "the", "recent", "introduction", "of", "newly", "non", "toxics", "and", "efficient", "antiestrogens", "which", "block", "the", "effect", "of", "estrogens", "from", "circulation", "have", "become", "drugs", "of", "first", "line", "in", "the", "metastasis", "illness", ".", "To", "compare", "the", "clinical", "evolution", "and", "the", "survival", "of", "patients", "with", "locally", "advanced", "breast", "cancer", "and", "metastasis", "with", "the", "use", "of", "two", "therapeutic", "modalities", ".", "Under", "informed", "consent", "20", "patients", "with", "diagnosis", "of", "breast", "cancer", "and", "out", "of", "oncological", "therapeutic", "processing", "were", "included", ".", "Randomly", "an", "inhibitor", "of", "the", "aromatase", "(", "anastrozole", ",", "1", "mg", "for", "day", ")", "was", "used", "in", "10", "patients", "and", "in", "the", "other", "10", "patients", "tamoxifen", "(", "20", "mg", "for", "day", ")", "both", "for", "2", "years", ",", "subject", "to", "verification", "of", "positive", "estrogens", "-", "progesterone", "receptors", ".", "Half", "of", "the", "patients", "of", "each", "group", "had", "a", "clinical", "stage", "III", ".", "The", "most", "frequent", "histological", "diagnosis", "was", "the", "ductal", "carcinoma", "in", "70", "%", "of", "the", "group", "with", "tamoxifen", "use", ",", "while", "in", "anastrozole", "group", "was", "90", "%", ";", "the", "mastectomy", "prior", "to", "the", "tamoxifen", "was", "carried", "out", "in", "60", "%", "of", "the", "patients", "and", "in", "50", "%", "of", "the", "group", "with", "anastrozole", ".", "The", "acceptable", "response", "to", "the", "processing", "in", "the", "patients", "with", "tamoxifen", "was", "complete", "in", "the", "60", "%", "of", "the", "cases", ",", "but", "with", "the", "use", "of", "anastrozole", "was", "80", "%", ";", "survival", "in", "the", "group", "with", "anastrozole", "was", "of", "100", "%", "in", "two", "years", "of", "follow", "up", ",", "while", "in", "women", "that", "received", "tamoxifen", "the", "survival", "was", "90", "%", "(", "p", "<", "0.001", ")", ".", "The", "use", "of", "anastrozole", "improved", "the", "survival", "as", "well", "as", "the", "quality", "of", "life", ",", "showing", "no", "side", "effects", "in", "this", "group", "of", "patients", "." ]

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[ "Effects", "of", "adjuvant", "exemestane", "versus", "anastrozole", "on", "bone", "mineral", "density", "for", "women", "with", "early", "breast", "cancer", "(", "MA.", "27", "B", ")", ":", "a", "companion", "analysis", "of", "a", "randomised", "controlled", "trial", ".", "Treatment", "of", "breast", "cancer", "with", "aromatase", "inhibitors", "is", "associated", "with", "damage", "to", "bones", ".", "NCIC", "CTG", "MA", ".", "27", "was", "an", "open", "-", "label", ",", "phase", "3", ",", "randomised", "controlled", "trial", "in", "which", "women", "with", "breast", "cancer", "were", "assigned", "to", "one", "of", "two", "adjuvant", "oral", "aromatase", "inhibitors", "-", "exemestane", "or", "anastrozole", ".", "We", "postulated", "that", "exemestane", "-", "a", "mildly", "androgenic", "steroid", "-", "might", "have", "a", "less", "detrimental", "effect", "on", "bone", "than", "non", "-", "steroidal", "anastrozole", ".", "In", "this", "companion", "study", "to", "MA", ".", "27", ",", "we", "compared", "changes", "in", "bone", "mineral", "density", "(", "BMD", ")", "in", "the", "lumbar", "spine", "and", "total", "hip", "between", "patients", "treated", "with", "exemestane", "and", "patients", "treated", "with", "anastrozole", ".", "In", "MA", ".", "27", ",", "postmenopausal", "women", "with", "early", "stage", "hormone", "(", "oestrogen", ")", "receptor", "-", "positive", "invasive", "breast", "cancer", "were", "randomly", "assigned", "to", "exemestane", "25", "mg", "versus", "anastrozole", "1", "mg", ",", "daily", ".", "MA.", "27", "B", "recruited", "two", "groups", "of", "women", "from", "MA", ".", "27", ":", "those", "with", "BMD", "T", "-", "scores", "of", "-", "2", "·", "0", "or", "more", "(", "up", "to", "2", "SDs", "below", "sex", "-", "matched", ",", "young", "adult", "mean", ")", "and", "those", "with", "at", "least", "one", "T", "-", "score", "(", "hip", "or", "spine", ")", "less", "than", "-", "2", "·", "0", ".", "Both", "groups", "received", "vitamin", "D", "and", "calcium", ";", "those", "with", "baseline", "T", "-", "scores", "of", "less", "than", "-", "2", "·", "0", "also", "received", "bisphosphonates", ".", "The", "primary", "endpoints", "were", "percent", "change", "of", "BMD", "at", "2", "years", "in", "lumbar", "spine", "and", "total", "hip", "for", "both", "groups", ".", "We", "analysed", "patients", "according", "to", "which", "aromatase", "inhibitor", "and", "T", "-", "score", "groups", "they", "were", "allocated", "to", "but", "BMD", "assessments", "ceased", "if", "patients", "deviated", "from", "protocol", ".", "This", "study", "is", "registered", "with", "ClinicalTrials.gov", ",", "NCT", "00354302", ".", "Between", "April", "24", ",", "2006", ",", "and", "May", "30", ",", "2008", ",", "300", "patients", "with", "baseline", "T", "-", "scores", "of", "-", "2", "·", "0", "or", "more", "were", "accrued", "(", "147", "allocated", "exemestane", ",", "153", "anastrozole", ")", ";", "and", "197", "patients", "with", "baseline", "T", "-", "scores", "of", "less", "than", "-", "2", "·", "0", "(", "101", "exemestane", ",", "96", "anastrozole", ")", ".", "For", "patients", "with", "T", "-", "scores", "greater", "than", "-", "2", "·", "0", "at", "baseline", ",", "mean", "change", "of", "bone", "mineral", "density", "in", "the", "spine", "at", "2", "years", "did", "not", "differ", "significantly", "between", "patients", "taking", "exemestane", "and", "patients", "taking", "anastrozole", "(", "-", "0", "·", "92", "%", ",", "95", "%", "CI", "-", "2", "·", "35", "to", "0", "·", "50", "vs", "-", "2", "·", "39", "%", ",", "95", "%", "CI", "-", "3", "·", "77", "to", "-", "1", "·", "01", ";", "p=", "0", "·", "08", ")", ".", "Respective", "mean", "loss", "in", "the", "hip", "was", "-", "1", "·", "93", "%", "(", "95", "%", "CI", "-", "2", "·", "93", "to", "-", "0", "·", "93", ")", "versus", "-", "2", "·", "71", "%", "(", "95", "%", "CI", "-", "4", "·", "32", "to", "-", "1", "·", "11", ";", "p=", "0", "·", "10", ")", ".", "Likewise", "for", "those", "who", "started", "with", "T", "-", "scores", "of", "less", "than", "-", "2", "·", "0", ",", "mean", "change", "of", "spine", "bone", "mineral", "density", "at", "2", "years", "did", "not", "differ", "significantly", "between", "the", "exemestane", "and", "anastrozole", "treatment", "groups", "(", "2", "·", "11", "%", ",", "95", "%", "CI", "-", "0", "·", "84", "to", "5", "·", "06", "vs", "3", "·", "72", "%", ",", "95", "%", "CI", "1", "·", "54", "to", "5", "·", "89", ";", "p=", "0", "·", "26", ")", ",", "nor", "did", "hip", "bone", "mineral", "density", "(", "2", "·", "09", "%", ",", "95", "%", "CI", "-", "1", "·", "45", "to", "5", "·", "63", "vs", "0", "·", "0", "%", ",", "95", "%", "CI", "-", "3", "·", "67", "to", "3", "·", "66", ";", "p=", "0", "·", "28", ")", ".", "Patients", "with", "baseline", "T", "-", "score", "of", "-", "2", "·", "0", "or", "more", "taking", "exemestane", "had", "two", "fragility", "fractures", "and", "two", "other", "fractures", ",", "those", "taking", "anastrozole", "had", "three", "fragility", "fractures", "and", "five", "other", "fractures", ".", "For", "patients", "who", "had", "baseline", "T", "-", "scores", "of", "less", "than", "-", "2", "·", "0", "taking", "exemestane", ",", "one", "had", "a", "fragility", "fracture", "and", "four", "had", "other", "fractures", ",", "whereas", "those", "taking", "anastrozole", "had", "five", "fragility", "fractures", "and", "one", "other", "fracture", ".", "Our", "results", "demonstrate", "that", "adjuvant", "treatment", "with", "aromatase", "inhibitors", "can", "be", "considered", "for", "breast", "cancer", "patients", "who", "have", "T", "-", "scores", "less", "than", "-", "2", "·", "0", ".", "Canadian", "Cancer", "Society", "Research", "Institute", ",", "Pfizer", ",", "Canadian", "Institutes", "of", "Health", "Research", "." ]

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