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Leiomyosarcomas is an umlsterm, heart is an umlsterm, vessels is an umlsterm, diseases is an umlsterm, Diagnosis is an umlsterm, symptoms is an umlsterm, pulmonary embolism is an umlsterm, man is an umlsterm, leiomyosarcoma is an umlsterm, pulmonary artery is an umlsterm, pulmonary valve is an umlsterm, right is an umlsterm, pulmonary arteries is an umlsterm, diagnosis is an umlsterm, surgical is an umlsterm, therapy is an umlsterm, survival is an umlsterm, operation is an umlsterm, patient is an umlsterm, disease is an umlsterm, diagnosis is an umlsterm, surgical is an umlsterm, review is an umlsterm, literature is an umlsterm | ZfuerHerzThoraxGefaesschirurgie.00140212.eng.abstr_task0 | Sentence: Leiomyosarcomas of the heart and great vessels are extremely rare and highly lethal diseases . Diagnosis is difficult due to their unspecific symptoms , which are frequently confused with other clinical conditions such as pulmonary embolism . This report describes a 31-year-old man with leiomyosarcoma of the pulmonary artery originating at the pulmonary valve and involving right ventricular outflow tract and central pulmonary arteries . Early diagnosis and aggressive surgical therapy has led to long-term survival ; five years after the operation the patient is alive and disease free . The importance of a timely diagnosis and radical surgical excision is delineated and a review of the literature included .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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] | Leiomyosarcomas of the heart and great vessels are extremely rare and highly lethal diseases . Diagnosis is difficult due to their unspecific symptoms , which are frequently confused with other clinical conditions such as pulmonary embolism . This report describes a 31-year-old man with leiomyosarcoma of the pulmonary artery originating at the pulmonary valve and involving right ventricular outflow tract and central pulmonary arteries . Early diagnosis and aggressive surgical therapy has led to long-term survival ; five years after the operation the patient is alive and disease free . The importance of a timely diagnosis and radical surgical excision is delineated and a review of the literature included . | [
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Leiomyosarcomas is an umlsterm, heart is an umlsterm, vessels is an umlsterm, diseases is an umlsterm, Diagnosis is an umlsterm, symptoms is an umlsterm, pulmonary embolism is an umlsterm, man is an umlsterm, leiomyosarcoma is an umlsterm, pulmonary artery is an umlsterm, pulmonary valve is an umlsterm, right is an umlsterm, pulmonary arteries is an umlsterm, diagnosis is an umlsterm, surgical is an umlsterm, therapy is an umlsterm, survival is an umlsterm, operation is an umlsterm, patient is an umlsterm, disease is an umlsterm, diagnosis is an umlsterm, surgical is an umlsterm, review is an umlsterm, literature is an umlsterm | ZfuerHerzThoraxGefaesschirurgie.00140212.eng.abstr_task1 | Sentence: Leiomyosarcomas of the heart and great vessels are extremely rare and highly lethal diseases . Diagnosis is difficult due to their unspecific symptoms , which are frequently confused with other clinical conditions such as pulmonary embolism . This report describes a 31-year-old man with leiomyosarcoma of the pulmonary artery originating at the pulmonary valve and involving right ventricular outflow tract and central pulmonary arteries . Early diagnosis and aggressive surgical therapy has led to long-term survival ; five years after the operation the patient is alive and disease free . The importance of a timely diagnosis and radical surgical excision is delineated and a review of the literature included .
Instructions: please typing these entity words according to sentence: Leiomyosarcomas, heart, vessels, diseases, Diagnosis, symptoms, pulmonary embolism, man, leiomyosarcoma, pulmonary artery, pulmonary valve, right, pulmonary arteries, diagnosis, surgical, therapy, survival, operation, patient, disease, diagnosis, surgical, review, literature
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] | Leiomyosarcomas of the heart and great vessels are extremely rare and highly lethal diseases . Diagnosis is difficult due to their unspecific symptoms , which are frequently confused with other clinical conditions such as pulmonary embolism . This report describes a 31-year-old man with leiomyosarcoma of the pulmonary artery originating at the pulmonary valve and involving right ventricular outflow tract and central pulmonary arteries . Early diagnosis and aggressive surgical therapy has led to long-term survival ; five years after the operation the patient is alive and disease free . The importance of a timely diagnosis and radical surgical excision is delineated and a review of the literature included . | [
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Leiomyosarcomas, heart, vessels, diseases, Diagnosis, symptoms, pulmonary embolism, man, leiomyosarcoma, pulmonary artery, pulmonary valve, right, pulmonary arteries, diagnosis, surgical, therapy, survival, operation, patient, disease, diagnosis, surgical, review, literature | ZfuerHerzThoraxGefaesschirurgie.00140212.eng.abstr_task2 | Sentence: Leiomyosarcomas of the heart and great vessels are extremely rare and highly lethal diseases . Diagnosis is difficult due to their unspecific symptoms , which are frequently confused with other clinical conditions such as pulmonary embolism . This report describes a 31-year-old man with leiomyosarcoma of the pulmonary artery originating at the pulmonary valve and involving right ventricular outflow tract and central pulmonary arteries . Early diagnosis and aggressive surgical therapy has led to long-term survival ; five years after the operation the patient is alive and disease free . The importance of a timely diagnosis and radical surgical excision is delineated and a review of the literature included .
Instructions: please extract entity words from the input sentence
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] | Leiomyosarcomas of the heart and great vessels are extremely rare and highly lethal diseases . Diagnosis is difficult due to their unspecific symptoms , which are frequently confused with other clinical conditions such as pulmonary embolism . This report describes a 31-year-old man with leiomyosarcoma of the pulmonary artery originating at the pulmonary valve and involving right ventricular outflow tract and central pulmonary arteries . Early diagnosis and aggressive surgical therapy has led to long-term survival ; five years after the operation the patient is alive and disease free . The importance of a timely diagnosis and radical surgical excision is delineated and a review of the literature included . | [
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Comparative effectiveness is a Outcome_Other, women with suspected coronary artery disease : is a Participant_Condition, women with suspected coronary artery disease ( CAD ) . is a Participant_Condition, ECG is a Intervention_Physical, ETT is a Intervention_Physical | 51378_task0 | Sentence: Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease : results from the What Is the Optimal Method for Ischemia Evaluation in Women ( WOMEN ) trial . BACKGROUND There is a paucity of randomized trials regarding diagnostic testing in women with suspected coronary artery disease ( CAD ) . It remains unclear whether the addition of myocardial perfusion imaging ( MPI ) to the standard ECG exercise treadmill test ( ETT ) provides incremental information to improve clinical decision making in women with suspected CAD . METHODS AND RESULTS We randomized symptomatic women with suspected CAD , an interpretable ECG , and ≥5 metabolic equivalents on the Duke Activity Status Index to 1 of 2 diagnostic strategies : ETT or exercise MPI . The primary end point was 2-year incidence of major adverse cardiac events , defined as CAD death or hospitalization for an acute coronary syndrome or heart failure . A total of 824 women were randomized to ETT or exercise MPI . For women randomized to ETT , ECG results were normal in 64 % , indeterminate in 16 % , and abnormal in 20 % . By comparison , the exercise MPI results were normal in 91 % , mildly abnormal in 3 % , and moderate to severely abnormal in 6 % . At 2 years , there was no difference in major adverse cardiac events ( 98.0 % for ETT and 97.7 % for MPI ; P=0.59 ) . Compared with ETT , index testing costs were higher for exercise MPI ( P < 0.001 ) , whereas downstream procedural costs were slightly lower ( P=0.0008 ) . Overall , the cumulative diagnostic cost savings was 48 % for ETT compared with exercise MPI ( P < 0.001 ) . CONCLUSIONS In low-risk , exercising women , a diagnostic strategy that uses ETT versus exercise MPI yields similar 2-year posttest outcomes while providing significant diagnostic cost savings . The ETT with selective follow-up testing should be considered as the initial diagnostic strategy in symptomatic women with suspected CAD . CLINICAL TRIAL REGISTRATION http : //www.clinicaltrials.gov . Unique identifier : NCT00282711 .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: Intervention_Physical, Outcome_Other, Participant_Condition
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Comparative effectiveness, women with suspected coronary artery disease :, women with suspected coronary artery disease ( CAD ) ., ECG, ETT | 51378_task2 | Sentence: Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease : results from the What Is the Optimal Method for Ischemia Evaluation in Women ( WOMEN ) trial . BACKGROUND There is a paucity of randomized trials regarding diagnostic testing in women with suspected coronary artery disease ( CAD ) . It remains unclear whether the addition of myocardial perfusion imaging ( MPI ) to the standard ECG exercise treadmill test ( ETT ) provides incremental information to improve clinical decision making in women with suspected CAD . METHODS AND RESULTS We randomized symptomatic women with suspected CAD , an interpretable ECG , and ≥5 metabolic equivalents on the Duke Activity Status Index to 1 of 2 diagnostic strategies : ETT or exercise MPI . The primary end point was 2-year incidence of major adverse cardiac events , defined as CAD death or hospitalization for an acute coronary syndrome or heart failure . A total of 824 women were randomized to ETT or exercise MPI . For women randomized to ETT , ECG results were normal in 64 % , indeterminate in 16 % , and abnormal in 20 % . By comparison , the exercise MPI results were normal in 91 % , mildly abnormal in 3 % , and moderate to severely abnormal in 6 % . At 2 years , there was no difference in major adverse cardiac events ( 98.0 % for ETT and 97.7 % for MPI ; P=0.59 ) . Compared with ETT , index testing costs were higher for exercise MPI ( P < 0.001 ) , whereas downstream procedural costs were slightly lower ( P=0.0008 ) . Overall , the cumulative diagnostic cost savings was 48 % for ETT compared with exercise MPI ( P < 0.001 ) . CONCLUSIONS In low-risk , exercising women , a diagnostic strategy that uses ETT versus exercise MPI yields similar 2-year posttest outcomes while providing significant diagnostic cost savings . The ETT with selective follow-up testing should be considered as the initial diagnostic strategy in symptomatic women with suspected CAD . CLINICAL TRIAL REGISTRATION http : //www.clinicaltrials.gov . Unique identifier : NCT00282711 .
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] | Comparative effectiveness of exercise electrocardiography with or without myocardial perfusion single photon emission computed tomography in women with suspected coronary artery disease : results from the What Is the Optimal Method for Ischemia Evaluation in Women ( WOMEN ) trial . BACKGROUND There is a paucity of randomized trials regarding diagnostic testing in women with suspected coronary artery disease ( CAD ) . It remains unclear whether the addition of myocardial perfusion imaging ( MPI ) to the standard ECG exercise treadmill test ( ETT ) provides incremental information to improve clinical decision making in women with suspected CAD . METHODS AND RESULTS We randomized symptomatic women with suspected CAD , an interpretable ECG , and ≥5 metabolic equivalents on the Duke Activity Status Index to 1 of 2 diagnostic strategies : ETT or exercise MPI . The primary end point was 2-year incidence of major adverse cardiac events , defined as CAD death or hospitalization for an acute coronary syndrome or heart failure . A total of 824 women were randomized to ETT or exercise MPI . For women randomized to ETT , ECG results were normal in 64 % , indeterminate in 16 % , and abnormal in 20 % . By comparison , the exercise MPI results were normal in 91 % , mildly abnormal in 3 % , and moderate to severely abnormal in 6 % . At 2 years , there was no difference in major adverse cardiac events ( 98.0 % for ETT and 97.7 % for MPI ; P=0.59 ) . Compared with ETT , index testing costs were higher for exercise MPI ( P < 0.001 ) , whereas downstream procedural costs were slightly lower ( P=0.0008 ) . Overall , the cumulative diagnostic cost savings was 48 % for ETT compared with exercise MPI ( P < 0.001 ) . CONCLUSIONS In low-risk , exercising women , a diagnostic strategy that uses ETT versus exercise MPI yields similar 2-year posttest outcomes while providing significant diagnostic cost savings . The ETT with selective follow-up testing should be considered as the initial diagnostic strategy in symptomatic women with suspected CAD . CLINICAL TRIAL REGISTRATION http : //www.clinicaltrials.gov . Unique identifier : NCT00282711 . | [
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broccoli intake is a Intervention_Pharmacological, markers related to oxidative stress and cancer risk is a Outcome_Physical, maintained a controlled diet is a Intervention_Control, DNA damage , insulin - like growth factor - I ( IGF - I ) and histone deacetylase ( HDAC ) . Ex vivo protection from H ( 2 ) O ( 2 ) -induced DNA damage and endogenous DNA damage is a Outcome_Physical, Strand breaks is a Outcome_Physical, oxidized purines is a Outcome_Physical, HDAC activity and IGF - I serum levels . is a Outcome_Physical, increase cell protection against DNA damage . is a Outcome_Physical, HDAC activity and IGF - I levels . is a Outcome_Physical | 39315_task0 | Sentence: Effect of broccoli intake on markers related to oxidative stress and cancer risk in healthy smokers and nonsmokers . Cruciferous vegetables ( CVs ) have been widely studied for their anticarcinogenic properties . The aim of the present study was to evaluate the protective effect of broccoli intake in smokers and nonsmokers . Twenty young healthy males ( 10 smokers and 10 nonsmokers ) were randomized in a cross-over design and received a portion of broccoli ( 200 g ) or maintained a controlled diet for 10 days each . The two periods were separated by a wash-out period ( 20 days ) . Blood samples were collected at 0 , 10 , 30 , and 40 days and used for the evaluation of DNA damage , insulin-like growth factor-I ( IGF-I ) and histone deacetylase ( HDAC ) . Ex vivo protection from H ( 2 ) O ( 2 ) -induced DNA damage and endogenous DNA damage were evaluated in lymphocytes by means of the comet assay . Strand breaks decreased significantly after the broccoli diet in smokers as well as in nonsmokers ( -22.2 % ; P < 0.0001 ) , whereas oxidized purines decreased significantly only in smokers ( -51.0 % ; P < 0.0001 ) . Broccoli intake did not modify HDAC activity and IGF-I serum levels . Our results strengthen the importance of consuming CVs to increase cell protection against DNA damage . Future investigation , with different amount of broccoli and/or different time of exposure , is needed to understand the lack of effect on HDAC activity and IGF-I levels .
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] | Effect of broccoli intake on markers related to oxidative stress and cancer risk in healthy smokers and nonsmokers . Cruciferous vegetables ( CVs ) have been widely studied for their anticarcinogenic properties . The aim of the present study was to evaluate the protective effect of broccoli intake in smokers and nonsmokers . Twenty young healthy males ( 10 smokers and 10 nonsmokers ) were randomized in a cross-over design and received a portion of broccoli ( 200 g ) or maintained a controlled diet for 10 days each . The two periods were separated by a wash-out period ( 20 days ) . Blood samples were collected at 0 , 10 , 30 , and 40 days and used for the evaluation of DNA damage , insulin-like growth factor-I ( IGF-I ) and histone deacetylase ( HDAC ) . Ex vivo protection from H ( 2 ) O ( 2 ) -induced DNA damage and endogenous DNA damage were evaluated in lymphocytes by means of the comet assay . Strand breaks decreased significantly after the broccoli diet in smokers as well as in nonsmokers ( -22.2 % ; P < 0.0001 ) , whereas oxidized purines decreased significantly only in smokers ( -51.0 % ; P < 0.0001 ) . Broccoli intake did not modify HDAC activity and IGF-I serum levels . Our results strengthen the importance of consuming CVs to increase cell protection against DNA damage . Future investigation , with different amount of broccoli and/or different time of exposure , is needed to understand the lack of effect on HDAC activity and IGF-I levels . | [
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Chirurgie is an umlsterm, Behandlung is an umlsterm, Methode is an umlsterm, Randstreifen - Methode is an umlsterm, Methode is an umlsterm, Tumorentfernung is an umlsterm, Gewebes is an umlsterm, Technik is an umlsterm, Tumorexzision is an umlsterm, Praeparatebeurteilung is an umlsterm | DerHautarzt.50460607.ger.abstr_task1 | Sentence: Die mikrographische Chirurgie ist heute ein unverzichtbares therapeutisches Verfahren in der Behandlung von Basaliomen . Die Methode ist in den letzten 20 Jahren weiterentwickelt und modifiziert worden . Gegenwaertig stehen drei Variationen zur Auswahl : Mohs-Methode Randstreifen-Methode ( " , Tuebinger Torte " ) und " Muenchner Methode " . Alle drei Verfahren haben das gleiche Ziel : radikale Tumorentfernung unter Schonung des nicht befallenen Gewebes der Umgebung . Sie weisen jedoch bezueglich der Technik der Tumorexzision , der Anfestigung der histologischen Schnitte und der histologischen Praeparatebeurteilung wesentliche Unterschiede auf . Es wird eine methodische Bestandsaufnahme vorgenommen und Unterschiede sowie Vor- und Nachteile dargestellt .
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Chirurgie, Behandlung, Methode, Randstreifen - Methode, Methode, Tumorentfernung, Gewebes, Technik, Tumorexzision, Praeparatebeurteilung | DerHautarzt.50460607.ger.abstr_task2 | Sentence: Die mikrographische Chirurgie ist heute ein unverzichtbares therapeutisches Verfahren in der Behandlung von Basaliomen . Die Methode ist in den letzten 20 Jahren weiterentwickelt und modifiziert worden . Gegenwaertig stehen drei Variationen zur Auswahl : Mohs-Methode Randstreifen-Methode ( " , Tuebinger Torte " ) und " Muenchner Methode " . Alle drei Verfahren haben das gleiche Ziel : radikale Tumorentfernung unter Schonung des nicht befallenen Gewebes der Umgebung . Sie weisen jedoch bezueglich der Technik der Tumorexzision , der Anfestigung der histologischen Schnitte und der histologischen Praeparatebeurteilung wesentliche Unterschiede auf . Es wird eine methodische Bestandsaufnahme vorgenommen und Unterschiede sowie Vor- und Nachteile dargestellt .
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accident is an umlsterm, injury is an umlsterm, patients is an umlsterm, accident is an umlsterm, eye is an umlsterm, police is an umlsterm, emergency is an umlsterm, medical staff is an umlsterm, Abbreviated Injury Scale is an umlsterm, body region is an umlsterm, injury is an umlsterm, all is an umlsterm, patients is an umlsterm, accidents is an umlsterm, injury is an umlsterm, incidence is an umlsterm, head is an umlsterm, motor vehicle is an umlsterm, chest is an umlsterm, abdomen is an umlsterm, pelvis is an umlsterm, lower extremities is an umlsterm, motorcycle is an umlsterm, accidents is an umlsterm, spine is an umlsterm, accidental falls is an umlsterm, injury is an umlsterm, head is an umlsterm, pelvis is an umlsterm, lower extremity is an umlsterm, accidental fall is an umlsterm, head is an umlsterm, pelvis is an umlsterm, lower extremity is an umlsterm, injury is an umlsterm, accident is an umlsterm, physician is an umlsterm, resuscitation is an umlsterm | DerUnfallchirurg.60990633.eng.abstr_task0 | Sentence: To investigate the correlation between the mechanism of an accident and the resulting injury pattern we reviewed the data of 195 prospectively documented multiply traumatized patients . Information on the accident was based on descriptions given by eye witnesses , police and the emergency medical staff . Only moderate to severe lesions ( AIS > =3 ; Abbreviated Injury Scale Version 1990 ) of each body region were analyzed . The mean injury severity ( ISS ) for all these patients was 39.5 ( 18 - 75 ) ; the lethality was 34% . Different types of accidents led to various injury patterns . We found a high incidence of lesions of the head in frontal ( F ) motor vehicle crashes ( MVC ) nonbelted ( 76% ) , of the chest in lateral ( L ) MVCs ( 80% ) , of the abdomen in F MVCs belted and in L MVCs ( 60% ) , of the pelvis after suicidal fall ( SF ; 69% ) and of the lower extremities in motorcycle accidents ( 90% ) , SFs ( 69% ) and collisions with a train ( 67% ) . Severe lesions of the spine were frequently seen after accidental falls ( 41% ) , SFs ( 30% ) and F MVCs belted ( 25% ) . There was a very substantial difference in the injury pattern after suicidal jump ( 26% head , 69% pelvis , 65% lower extremity lesions ) and accidental fall ( 54% head , 19% pelvis , 23% lower extremity lesions ) . As a result of the correlation with specific injury patterns , the preceding mechanism of accident should be exactly documented and considered by the physician during the early phase of resuscitation .
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] | To investigate the correlation between the mechanism of an accident and the resulting injury pattern we reviewed the data of 195 prospectively documented multiply traumatized patients . Information on the accident was based on descriptions given by eye witnesses , police and the emergency medical staff . Only moderate to severe lesions ( AIS > =3 ; Abbreviated Injury Scale Version 1990 ) of each body region were analyzed . The mean injury severity ( ISS ) for all these patients was 39.5 ( 18 - 75 ) ; the lethality was 34% . Different types of accidents led to various injury patterns . We found a high incidence of lesions of the head in frontal ( F ) motor vehicle crashes ( MVC ) nonbelted ( 76% ) , of the chest in lateral ( L ) MVCs ( 80% ) , of the abdomen in F MVCs belted and in L MVCs ( 60% ) , of the pelvis after suicidal fall ( SF ; 69% ) and of the lower extremities in motorcycle accidents ( 90% ) , SFs ( 69% ) and collisions with a train ( 67% ) . Severe lesions of the spine were frequently seen after accidental falls ( 41% ) , SFs ( 30% ) and F MVCs belted ( 25% ) . There was a very substantial difference in the injury pattern after suicidal jump ( 26% head , 69% pelvis , 65% lower extremity lesions ) and accidental fall ( 54% head , 19% pelvis , 23% lower extremity lesions ) . As a result of the correlation with specific injury patterns , the preceding mechanism of accident should be exactly documented and considered by the physician during the early phase of resuscitation . | [
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"umlsterm"
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accident is an umlsterm, injury is an umlsterm, patients is an umlsterm, accident is an umlsterm, eye is an umlsterm, police is an umlsterm, emergency is an umlsterm, medical staff is an umlsterm, Abbreviated Injury Scale is an umlsterm, body region is an umlsterm, injury is an umlsterm, all is an umlsterm, patients is an umlsterm, accidents is an umlsterm, injury is an umlsterm, incidence is an umlsterm, head is an umlsterm, motor vehicle is an umlsterm, chest is an umlsterm, abdomen is an umlsterm, pelvis is an umlsterm, lower extremities is an umlsterm, motorcycle is an umlsterm, accidents is an umlsterm, spine is an umlsterm, accidental falls is an umlsterm, injury is an umlsterm, head is an umlsterm, pelvis is an umlsterm, lower extremity is an umlsterm, accidental fall is an umlsterm, head is an umlsterm, pelvis is an umlsterm, lower extremity is an umlsterm, injury is an umlsterm, accident is an umlsterm, physician is an umlsterm, resuscitation is an umlsterm | DerUnfallchirurg.60990633.eng.abstr_task1 | Sentence: To investigate the correlation between the mechanism of an accident and the resulting injury pattern we reviewed the data of 195 prospectively documented multiply traumatized patients . Information on the accident was based on descriptions given by eye witnesses , police and the emergency medical staff . Only moderate to severe lesions ( AIS > =3 ; Abbreviated Injury Scale Version 1990 ) of each body region were analyzed . The mean injury severity ( ISS ) for all these patients was 39.5 ( 18 - 75 ) ; the lethality was 34% . Different types of accidents led to various injury patterns . We found a high incidence of lesions of the head in frontal ( F ) motor vehicle crashes ( MVC ) nonbelted ( 76% ) , of the chest in lateral ( L ) MVCs ( 80% ) , of the abdomen in F MVCs belted and in L MVCs ( 60% ) , of the pelvis after suicidal fall ( SF ; 69% ) and of the lower extremities in motorcycle accidents ( 90% ) , SFs ( 69% ) and collisions with a train ( 67% ) . Severe lesions of the spine were frequently seen after accidental falls ( 41% ) , SFs ( 30% ) and F MVCs belted ( 25% ) . There was a very substantial difference in the injury pattern after suicidal jump ( 26% head , 69% pelvis , 65% lower extremity lesions ) and accidental fall ( 54% head , 19% pelvis , 23% lower extremity lesions ) . As a result of the correlation with specific injury patterns , the preceding mechanism of accident should be exactly documented and considered by the physician during the early phase of resuscitation .
Instructions: please typing these entity words according to sentence: accident, injury, patients, accident, eye, police, emergency, medical staff, Abbreviated Injury Scale, body region, injury, all, patients, accidents, injury, incidence, head, motor vehicle, chest, abdomen, pelvis, lower extremities, motorcycle, accidents, spine, accidental falls, injury, head, pelvis, lower extremity, accidental fall, head, pelvis, lower extremity, injury, accident, physician, resuscitation
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] | To investigate the correlation between the mechanism of an accident and the resulting injury pattern we reviewed the data of 195 prospectively documented multiply traumatized patients . Information on the accident was based on descriptions given by eye witnesses , police and the emergency medical staff . Only moderate to severe lesions ( AIS > =3 ; Abbreviated Injury Scale Version 1990 ) of each body region were analyzed . The mean injury severity ( ISS ) for all these patients was 39.5 ( 18 - 75 ) ; the lethality was 34% . Different types of accidents led to various injury patterns . We found a high incidence of lesions of the head in frontal ( F ) motor vehicle crashes ( MVC ) nonbelted ( 76% ) , of the chest in lateral ( L ) MVCs ( 80% ) , of the abdomen in F MVCs belted and in L MVCs ( 60% ) , of the pelvis after suicidal fall ( SF ; 69% ) and of the lower extremities in motorcycle accidents ( 90% ) , SFs ( 69% ) and collisions with a train ( 67% ) . Severe lesions of the spine were frequently seen after accidental falls ( 41% ) , SFs ( 30% ) and F MVCs belted ( 25% ) . There was a very substantial difference in the injury pattern after suicidal jump ( 26% head , 69% pelvis , 65% lower extremity lesions ) and accidental fall ( 54% head , 19% pelvis , 23% lower extremity lesions ) . As a result of the correlation with specific injury patterns , the preceding mechanism of accident should be exactly documented and considered by the physician during the early phase of resuscitation . | [
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"umlsterm"
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accident, injury, patients, accident, eye, police, emergency, medical staff, Abbreviated Injury Scale, body region, injury, all, patients, accidents, injury, incidence, head, motor vehicle, chest, abdomen, pelvis, lower extremities, motorcycle, accidents, spine, accidental falls, injury, head, pelvis, lower extremity, accidental fall, head, pelvis, lower extremity, injury, accident, physician, resuscitation | DerUnfallchirurg.60990633.eng.abstr_task2 | Sentence: To investigate the correlation between the mechanism of an accident and the resulting injury pattern we reviewed the data of 195 prospectively documented multiply traumatized patients . Information on the accident was based on descriptions given by eye witnesses , police and the emergency medical staff . Only moderate to severe lesions ( AIS > =3 ; Abbreviated Injury Scale Version 1990 ) of each body region were analyzed . The mean injury severity ( ISS ) for all these patients was 39.5 ( 18 - 75 ) ; the lethality was 34% . Different types of accidents led to various injury patterns . We found a high incidence of lesions of the head in frontal ( F ) motor vehicle crashes ( MVC ) nonbelted ( 76% ) , of the chest in lateral ( L ) MVCs ( 80% ) , of the abdomen in F MVCs belted and in L MVCs ( 60% ) , of the pelvis after suicidal fall ( SF ; 69% ) and of the lower extremities in motorcycle accidents ( 90% ) , SFs ( 69% ) and collisions with a train ( 67% ) . Severe lesions of the spine were frequently seen after accidental falls ( 41% ) , SFs ( 30% ) and F MVCs belted ( 25% ) . There was a very substantial difference in the injury pattern after suicidal jump ( 26% head , 69% pelvis , 65% lower extremity lesions ) and accidental fall ( 54% head , 19% pelvis , 23% lower extremity lesions ) . As a result of the correlation with specific injury patterns , the preceding mechanism of accident should be exactly documented and considered by the physician during the early phase of resuscitation .
Instructions: please extract entity words from the input sentence
| [
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] | To investigate the correlation between the mechanism of an accident and the resulting injury pattern we reviewed the data of 195 prospectively documented multiply traumatized patients . Information on the accident was based on descriptions given by eye witnesses , police and the emergency medical staff . Only moderate to severe lesions ( AIS > =3 ; Abbreviated Injury Scale Version 1990 ) of each body region were analyzed . The mean injury severity ( ISS ) for all these patients was 39.5 ( 18 - 75 ) ; the lethality was 34% . Different types of accidents led to various injury patterns . We found a high incidence of lesions of the head in frontal ( F ) motor vehicle crashes ( MVC ) nonbelted ( 76% ) , of the chest in lateral ( L ) MVCs ( 80% ) , of the abdomen in F MVCs belted and in L MVCs ( 60% ) , of the pelvis after suicidal fall ( SF ; 69% ) and of the lower extremities in motorcycle accidents ( 90% ) , SFs ( 69% ) and collisions with a train ( 67% ) . Severe lesions of the spine were frequently seen after accidental falls ( 41% ) , SFs ( 30% ) and F MVCs belted ( 25% ) . There was a very substantial difference in the injury pattern after suicidal jump ( 26% head , 69% pelvis , 65% lower extremity lesions ) and accidental fall ( 54% head , 19% pelvis , 23% lower extremity lesions ) . As a result of the correlation with specific injury patterns , the preceding mechanism of accident should be exactly documented and considered by the physician during the early phase of resuscitation . | [
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prolactin is a protein, dopamine is a compound | DS.d954_task0 | Sentence: Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were determined.
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prolactin is a protein, dopamine is a compound | DS.d954_task1 | Sentence: Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were determined.
Instructions: please typing these entity words according to sentence: prolactin, dopamine
Options: compound, protein
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prolactin, dopamine | DS.d954_task2 | Sentence: Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were determined.
Instructions: please extract entity words from the input sentence
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surgery is an umlsterm, Thoracic Surgery is an umlsterm, Vascular Surgery is an umlsterm, Surgery is an umlsterm, Trauma is an umlsterm, Surgery is an umlsterm, it 's is an umlsterm, research is an umlsterm, research is an umlsterm, trauma is an umlsterm, surgery is an umlsterm, future is an umlsterm, programs is an umlsterm, aim is an umlsterm, survey is an umlsterm, research is an umlsterm, Germany is an umlsterm, questionnaires is an umlsterm, evaluation is an umlsterm, deficiencies is an umlsterm, personnel is an umlsterm, budget is an umlsterm, coordination is an umlsterm, resources is an umlsterm, Society is an umlsterm, Trauma is an umlsterm, Surgery is an umlsterm, coordination is an umlsterm, research activities is an umlsterm, funds is an umlsterm, teaching hospitals is an umlsterm, university is an umlsterm, research is an umlsterm, programs is an umlsterm, financial is an umlsterm, environment is an umlsterm | DerUnfallchirurg.91020505.eng.abstr_task0 | Sentence: The field surgery has been structured into four specialties of equal importance that are Thoracic Surgery , Vascular Surgery , Visceral Surgery and last but not least Trauma Surgery . Each specialty defines it's research tasks . Therefore it is necessary to evaluate the situation of research in trauma surgery and define future topics and programs . The aim of this survey was to cover the present research situation in Germany . Out of the 200 questionnaires 112 were available for evaluation . The major deficiencies were stated to be a lack of personnel , budget and coordination of topics and resources . Of general interest was to initiate activities of the German Society for Trauma Surgery ( DGU ) in view of coordination of research activities , setting up of new funds and integration of teaching hospitals into university research programs . The data , shown in this article , may serve to start a discussion aiming on the improvement of the financial and scientific environment .
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] | The field surgery has been structured into four specialties of equal importance that are Thoracic Surgery , Vascular Surgery , Visceral Surgery and last but not least Trauma Surgery . Each specialty defines it's research tasks . Therefore it is necessary to evaluate the situation of research in trauma surgery and define future topics and programs . The aim of this survey was to cover the present research situation in Germany . Out of the 200 questionnaires 112 were available for evaluation . The major deficiencies were stated to be a lack of personnel , budget and coordination of topics and resources . Of general interest was to initiate activities of the German Society for Trauma Surgery ( DGU ) in view of coordination of research activities , setting up of new funds and integration of teaching hospitals into university research programs . The data , shown in this article , may serve to start a discussion aiming on the improvement of the financial and scientific environment . | [
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surgery is an umlsterm, Thoracic Surgery is an umlsterm, Vascular Surgery is an umlsterm, Surgery is an umlsterm, Trauma is an umlsterm, Surgery is an umlsterm, it 's is an umlsterm, research is an umlsterm, research is an umlsterm, trauma is an umlsterm, surgery is an umlsterm, future is an umlsterm, programs is an umlsterm, aim is an umlsterm, survey is an umlsterm, research is an umlsterm, Germany is an umlsterm, questionnaires is an umlsterm, evaluation is an umlsterm, deficiencies is an umlsterm, personnel is an umlsterm, budget is an umlsterm, coordination is an umlsterm, resources is an umlsterm, Society is an umlsterm, Trauma is an umlsterm, Surgery is an umlsterm, coordination is an umlsterm, research activities is an umlsterm, funds is an umlsterm, teaching hospitals is an umlsterm, university is an umlsterm, research is an umlsterm, programs is an umlsterm, financial is an umlsterm, environment is an umlsterm | DerUnfallchirurg.91020505.eng.abstr_task1 | Sentence: The field surgery has been structured into four specialties of equal importance that are Thoracic Surgery , Vascular Surgery , Visceral Surgery and last but not least Trauma Surgery . Each specialty defines it's research tasks . Therefore it is necessary to evaluate the situation of research in trauma surgery and define future topics and programs . The aim of this survey was to cover the present research situation in Germany . Out of the 200 questionnaires 112 were available for evaluation . The major deficiencies were stated to be a lack of personnel , budget and coordination of topics and resources . Of general interest was to initiate activities of the German Society for Trauma Surgery ( DGU ) in view of coordination of research activities , setting up of new funds and integration of teaching hospitals into university research programs . The data , shown in this article , may serve to start a discussion aiming on the improvement of the financial and scientific environment .
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role is an umlsterm, plasmapheresis is an umlsterm, intensive care unit is an umlsterm, ICU is an umlsterm, immunological disease is an umlsterm, pathophysiology is an umlsterm, date is an umlsterm, plasmapheresis is an umlsterm, treatment is an umlsterm, disorders is an umlsterm, immunosuppression is an umlsterm, human is an umlsterm, plasma is an umlsterm, therapy is an umlsterm, future is an umlsterm, methods is an umlsterm, immunosuppression is an umlsterm, plasmapheresis is an umlsterm, review is an umlsterm, plasmapheresis is an umlsterm, ICU is an umlsterm | IntensiveMedizin.80350349.eng.abstr_task0 | Sentence: The last two decades have seen a marked change in the role of plasmapheresis in the intensive care unit ( ICU ) . Initially regarded as highly effective in treating virtually any immunological disease , insights in pathophysiology and results from controlled trials have left only a few indications validated . To date , plasmapheresis is indicated for acute treatment of severe immunological disorders either unresponsive to immunosuppression or requiring large volumes of human plasma for therapy . In the future , more specific and less cumbersome methods of immunosuppression and immunomodulation might further limit indications of plasmapheresis . In this review , current indications and side-effects of plasmapheresis in the ICU setting are summarized .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
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role is an umlsterm, plasmapheresis is an umlsterm, intensive care unit is an umlsterm, ICU is an umlsterm, immunological disease is an umlsterm, pathophysiology is an umlsterm, date is an umlsterm, plasmapheresis is an umlsterm, treatment is an umlsterm, disorders is an umlsterm, immunosuppression is an umlsterm, human is an umlsterm, plasma is an umlsterm, therapy is an umlsterm, future is an umlsterm, methods is an umlsterm, immunosuppression is an umlsterm, plasmapheresis is an umlsterm, review is an umlsterm, plasmapheresis is an umlsterm, ICU is an umlsterm | IntensiveMedizin.80350349.eng.abstr_task1 | Sentence: The last two decades have seen a marked change in the role of plasmapheresis in the intensive care unit ( ICU ) . Initially regarded as highly effective in treating virtually any immunological disease , insights in pathophysiology and results from controlled trials have left only a few indications validated . To date , plasmapheresis is indicated for acute treatment of severe immunological disorders either unresponsive to immunosuppression or requiring large volumes of human plasma for therapy . In the future , more specific and less cumbersome methods of immunosuppression and immunomodulation might further limit indications of plasmapheresis . In this review , current indications and side-effects of plasmapheresis in the ICU setting are summarized .
Instructions: please typing these entity words according to sentence: role, plasmapheresis, intensive care unit, ICU, immunological disease, pathophysiology, date, plasmapheresis, treatment, disorders, immunosuppression, human, plasma, therapy, future, methods, immunosuppression, plasmapheresis, review, plasmapheresis, ICU
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role, plasmapheresis, intensive care unit, ICU, immunological disease, pathophysiology, date, plasmapheresis, treatment, disorders, immunosuppression, human, plasma, therapy, future, methods, immunosuppression, plasmapheresis, review, plasmapheresis, ICU | IntensiveMedizin.80350349.eng.abstr_task2 | Sentence: The last two decades have seen a marked change in the role of plasmapheresis in the intensive care unit ( ICU ) . Initially regarded as highly effective in treating virtually any immunological disease , insights in pathophysiology and results from controlled trials have left only a few indications validated . To date , plasmapheresis is indicated for acute treatment of severe immunological disorders either unresponsive to immunosuppression or requiring large volumes of human plasma for therapy . In the future , more specific and less cumbersome methods of immunosuppression and immunomodulation might further limit indications of plasmapheresis . In this review , current indications and side-effects of plasmapheresis in the ICU setting are summarized .
Instructions: please extract entity words from the input sentence
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] | The last two decades have seen a marked change in the role of plasmapheresis in the intensive care unit ( ICU ) . Initially regarded as highly effective in treating virtually any immunological disease , insights in pathophysiology and results from controlled trials have left only a few indications validated . To date , plasmapheresis is indicated for acute treatment of severe immunological disorders either unresponsive to immunosuppression or requiring large volumes of human plasma for therapy . In the future , more specific and less cumbersome methods of immunosuppression and immunomodulation might further limit indications of plasmapheresis . In this review , current indications and side-effects of plasmapheresis in the ICU setting are summarized . | [
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Cyp11b1 is a protein, CYP11B1 is a protein | DS.d603_task0 | Sentence: None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO2-DDE inhibits CYP11B1 activity on the protein level.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: protein
| [
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Cyp11b1 is a protein, CYP11B1 is a protein | DS.d603_task1 | Sentence: None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO2-DDE inhibits CYP11B1 activity on the protein level.
Instructions: please typing these entity words according to sentence: Cyp11b1, CYP11B1
Options: protein
| [
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Cyp11b1, CYP11B1 | DS.d603_task2 | Sentence: None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO2-DDE inhibits CYP11B1 activity on the protein level.
Instructions: please extract entity words from the input sentence
| [
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traumatic optic neuropathy is an umlsterm, disease is an umlsterm, treatment is an umlsterm, therapy is an umlsterm, literature is an umlsterm, spinal cord trauma is an umlsterm, steroid is an umlsterm, therapy is an umlsterm, secondary is an umlsterm, trauma is an umlsterm, surgical decompression is an umlsterm, optic nerve is an umlsterm | HNO.80460152.eng.abstr_task0 | Sentence: Background : Indirect traumatic optic neuropathy represents a severe , potential vision-threatening disease process that requires close interdisciplinary cooperation for treatment . In general , any therapy has been dis-cussed controversially in the literature . Based upon experiences with spinal cord trauma , high-dose steroid therapy is recommended initially to minimize secondary consequences following orbital trauma . The usefulness of surgical decompression of the optic nerve has been confirmed in several studies but is still not recommended in principle .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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] | Background : Indirect traumatic optic neuropathy represents a severe , potential vision-threatening disease process that requires close interdisciplinary cooperation for treatment . In general , any therapy has been dis-cussed controversially in the literature . Based upon experiences with spinal cord trauma , high-dose steroid therapy is recommended initially to minimize secondary consequences following orbital trauma . The usefulness of surgical decompression of the optic nerve has been confirmed in several studies but is still not recommended in principle . | [
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traumatic optic neuropathy is an umlsterm, disease is an umlsterm, treatment is an umlsterm, therapy is an umlsterm, literature is an umlsterm, spinal cord trauma is an umlsterm, steroid is an umlsterm, therapy is an umlsterm, secondary is an umlsterm, trauma is an umlsterm, surgical decompression is an umlsterm, optic nerve is an umlsterm | HNO.80460152.eng.abstr_task1 | Sentence: Background : Indirect traumatic optic neuropathy represents a severe , potential vision-threatening disease process that requires close interdisciplinary cooperation for treatment . In general , any therapy has been dis-cussed controversially in the literature . Based upon experiences with spinal cord trauma , high-dose steroid therapy is recommended initially to minimize secondary consequences following orbital trauma . The usefulness of surgical decompression of the optic nerve has been confirmed in several studies but is still not recommended in principle .
Instructions: please typing these entity words according to sentence: traumatic optic neuropathy, disease, treatment, therapy, literature, spinal cord trauma, steroid, therapy, secondary, trauma, surgical decompression, optic nerve
Options: umlsterm
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] | Background : Indirect traumatic optic neuropathy represents a severe , potential vision-threatening disease process that requires close interdisciplinary cooperation for treatment . In general , any therapy has been dis-cussed controversially in the literature . Based upon experiences with spinal cord trauma , high-dose steroid therapy is recommended initially to minimize secondary consequences following orbital trauma . The usefulness of surgical decompression of the optic nerve has been confirmed in several studies but is still not recommended in principle . | [
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traumatic optic neuropathy, disease, treatment, therapy, literature, spinal cord trauma, steroid, therapy, secondary, trauma, surgical decompression, optic nerve | HNO.80460152.eng.abstr_task2 | Sentence: Background : Indirect traumatic optic neuropathy represents a severe , potential vision-threatening disease process that requires close interdisciplinary cooperation for treatment . In general , any therapy has been dis-cussed controversially in the literature . Based upon experiences with spinal cord trauma , high-dose steroid therapy is recommended initially to minimize secondary consequences following orbital trauma . The usefulness of surgical decompression of the optic nerve has been confirmed in several studies but is still not recommended in principle .
Instructions: please extract entity words from the input sentence
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Object relationships is an umlsterm, treatment is an umlsterm, patients is an umlsterm, psychosomatic disorders is an umlsterm, measures is an umlsterm, analyst 's is an umlsterm, countertransference is an umlsterm, feelings is an umlsterm, futility is an umlsterm, hand is an umlsterm, fantasies is an umlsterm, powers is an umlsterm, object relationship is an umlsterm, work is an umlsterm, family is an umlsterm, self - object is an umlsterm, transference is an umlsterm, countertransference is an umlsterm, therapeutic is an umlsterm | ForumDerPsychoanalyse.00160261.eng.abstr_task0 | Sentence: Object relationships developed in the treatment of patients with psychosomatic disorders require specific measures in handling the analyst's countertransference . Frequently feelings of tedium and emptiness as defence against either helplessness and futility may be experienced or , on the other hand , fantasies of omnipotence or magical healing powers . Comprehending one's repressed emotional responses contributes to a beneficial analytical process , in the course of which the analyst is appropriated as a Siamese self-object . The specific quality of this object relationship adds intrinsic significance beyond the normal scope of analytical work on the patient's relationships with his family . On the basis of the dynamics of the self-object relationship insight into the processes of transference and countertransference and therapeutic consequences are developed .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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Instructions: please typing these entity words according to sentence: Object relationships, treatment, patients, psychosomatic disorders, measures, analyst 's, countertransference, feelings, futility, hand, fantasies, powers, object relationship, work, family, self - object, transference, countertransference, therapeutic
Options: umlsterm
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Object relationships, treatment, patients, psychosomatic disorders, measures, analyst 's, countertransference, feelings, futility, hand, fantasies, powers, object relationship, work, family, self - object, transference, countertransference, therapeutic | ForumDerPsychoanalyse.00160261.eng.abstr_task2 | Sentence: Object relationships developed in the treatment of patients with psychosomatic disorders require specific measures in handling the analyst's countertransference . Frequently feelings of tedium and emptiness as defence against either helplessness and futility may be experienced or , on the other hand , fantasies of omnipotence or magical healing powers . Comprehending one's repressed emotional responses contributes to a beneficial analytical process , in the course of which the analyst is appropriated as a Siamese self-object . The specific quality of this object relationship adds intrinsic significance beyond the normal scope of analytical work on the patient's relationships with his family . On the basis of the dynamics of the self-object relationship insight into the processes of transference and countertransference and therapeutic consequences are developed .
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"umlsterm"
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tumor necrosis factor alpha is a Protein, tumor necrosis factor alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein | 1653056_task0 | Sentence: NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes. In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha). In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway. We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B. Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not. Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged. TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators. Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells. Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases. Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step.
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NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes. In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha). In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway. We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B. Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not. Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged. TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators. Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells. Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases. Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step. | [
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"Protein"
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tumor necrosis factor alpha is a Protein, tumor necrosis factor alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein, TNF alpha is a Protein | 1653056_task1 | Sentence: NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes. In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha). In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway. We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B. Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not. Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged. TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators. Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells. Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases. Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step.
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NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes. In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha). In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway. We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B. Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not. Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged. TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators. Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells. Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases. Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step. | [
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tumor necrosis factor alpha, tumor necrosis factor alpha, TNF alpha, TNF alpha, TNF alpha, TNF alpha, TNF alpha, TNF alpha, TNF alpha, TNF alpha | 1653056_task2 | Sentence: NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes. In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha). In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway. We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B. Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not. Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged. TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators. Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells. Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases. Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step.
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Kinderchirurgie is an umlsterm, Kinder is an umlsterm, Gastroschisis is an umlsterm, Komplikationen is an umlsterm, Lebensqualitaet is an umlsterm, Langzeitverlaeufe is an umlsterm, Kinder is an umlsterm, Kinder is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Neonatologie is an umlsterm, Diagnose is an umlsterm, Literatur is an umlsterm, lebensbedrohlichen is an umlsterm, Drucksteigerung is an umlsterm, Amnion is an umlsterm, Silo - Technik is an umlsterm, Nabel is an umlsterm, Drucks is an umlsterm, Langzeitbeobachtungen is an umlsterm, Lebensqualitaet is an umlsterm, Kinder is an umlsterm, Ausbildung is an umlsterm, Lebens is an umlsterm, Schwangerschaft is an umlsterm, Beratung is an umlsterm, Kinderchirurg is an umlsterm | DerChirurg.00711256.ger.abstr_task0 | Sentence: Zusammenfassung . An der Klinik fuer Kinderchirurgie des Universitaetsklinikums Luebeck wurden 1970-1998 35 Kinder mit einer Omphalocele ( OC ) und 31 mit einer Gastroschisis ( GS ) operiert . 40 der 43 Ueberlebenden wurden 1990 nachuntersucht , 30 Faelle 1999 aktualisiert und 12 neue hinzugefuegt . Neben den fruehen Komplikationen wurden die Lebensqualitaet und Langzeitverlaeufe der Kinder analysiert . Der Nachuntersuchungszeitraum betrug 1-28 Jahre . 28 OCs waren groesser als 5 cm , 25 mal gelang der Direktverschluss , bei den GSs 20 mal primaer ohne Ersatzmaterial . 18 OC-Kinder bzw. 8 GS-Kinder litten unter Kombinationsfehlbildungen ; diese wurden mitversorgt . 20 % der Kinder mit OC verstarben meist aufgrund komplexer Fehlbildungen , bei den GSs 12,9 % wegen septischer Komplikationen , kombiniert mit weiteren Fehlbildungen . Nach 1990 ueberlebten alle unsere Patienten . Neben der Letalitaet waren auch die Folgeoperationen in der letzten Dekade ruecklaeufig . Fuer die verbesserten Ergebnisse sind Fortschritte der operativen Behandlung mit den medizinischen und technischen Fortschritten in der Neonatologie ursaechlich . Die Abnahme der Begleitfehlbildungen erklaert sich durch die Zunahme der praenatalen Diagnose mit konsekutiver Interruptio . Die aktuelle Literatur und unsere Ergebnisse heben die Vorteile des fruehzeitigen Primaerverschlusses hervor . Bei grossen Defekten mit der Gefahr einer lebensbedrohlichen Drucksteigerung bieten sich z . B. der Defektverschluss mit Dura und/oder Amnion oder die ( modifizierte ) Silo-Technik an . Aus kosmetischen Gruenden sollte der Nabel rekonstruiert werden . Messungen des intraabdominellen Drucks koennen in Ausnahmefaellen hilfreich eingesetzt werden . Langzeitbeobachtungen des Verlaufs und der Lebensqualitaet zeigen , dass alle Kinder mit Ausnahme derer mit schweren Begleitfehlbildungen sich normal entwickeln bzw. Rueckstaende rasch aufholen . Ausbildung und Taetigkeiten des taeglichen Lebens sind problemlos moeglich . Eine isolierte GS oder OC stellt heute keine Indikation zur Beendigung der Schwangerschaft mehr dar . In die Beratung sollte auf jeden Fall ein Kinderchirurg miteinbezogen werden .
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Kinderchirurgie is an umlsterm, Kinder is an umlsterm, Gastroschisis is an umlsterm, Komplikationen is an umlsterm, Lebensqualitaet is an umlsterm, Langzeitverlaeufe is an umlsterm, Kinder is an umlsterm, Kinder is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Neonatologie is an umlsterm, Diagnose is an umlsterm, Literatur is an umlsterm, lebensbedrohlichen is an umlsterm, Drucksteigerung is an umlsterm, Amnion is an umlsterm, Silo - Technik is an umlsterm, Nabel is an umlsterm, Drucks is an umlsterm, Langzeitbeobachtungen is an umlsterm, Lebensqualitaet is an umlsterm, Kinder is an umlsterm, Ausbildung is an umlsterm, Lebens is an umlsterm, Schwangerschaft is an umlsterm, Beratung is an umlsterm, Kinderchirurg is an umlsterm | DerChirurg.00711256.ger.abstr_task1 | Sentence: Zusammenfassung . An der Klinik fuer Kinderchirurgie des Universitaetsklinikums Luebeck wurden 1970-1998 35 Kinder mit einer Omphalocele ( OC ) und 31 mit einer Gastroschisis ( GS ) operiert . 40 der 43 Ueberlebenden wurden 1990 nachuntersucht , 30 Faelle 1999 aktualisiert und 12 neue hinzugefuegt . Neben den fruehen Komplikationen wurden die Lebensqualitaet und Langzeitverlaeufe der Kinder analysiert . Der Nachuntersuchungszeitraum betrug 1-28 Jahre . 28 OCs waren groesser als 5 cm , 25 mal gelang der Direktverschluss , bei den GSs 20 mal primaer ohne Ersatzmaterial . 18 OC-Kinder bzw. 8 GS-Kinder litten unter Kombinationsfehlbildungen ; diese wurden mitversorgt . 20 % der Kinder mit OC verstarben meist aufgrund komplexer Fehlbildungen , bei den GSs 12,9 % wegen septischer Komplikationen , kombiniert mit weiteren Fehlbildungen . Nach 1990 ueberlebten alle unsere Patienten . Neben der Letalitaet waren auch die Folgeoperationen in der letzten Dekade ruecklaeufig . Fuer die verbesserten Ergebnisse sind Fortschritte der operativen Behandlung mit den medizinischen und technischen Fortschritten in der Neonatologie ursaechlich . Die Abnahme der Begleitfehlbildungen erklaert sich durch die Zunahme der praenatalen Diagnose mit konsekutiver Interruptio . Die aktuelle Literatur und unsere Ergebnisse heben die Vorteile des fruehzeitigen Primaerverschlusses hervor . Bei grossen Defekten mit der Gefahr einer lebensbedrohlichen Drucksteigerung bieten sich z . B. der Defektverschluss mit Dura und/oder Amnion oder die ( modifizierte ) Silo-Technik an . Aus kosmetischen Gruenden sollte der Nabel rekonstruiert werden . Messungen des intraabdominellen Drucks koennen in Ausnahmefaellen hilfreich eingesetzt werden . Langzeitbeobachtungen des Verlaufs und der Lebensqualitaet zeigen , dass alle Kinder mit Ausnahme derer mit schweren Begleitfehlbildungen sich normal entwickeln bzw. Rueckstaende rasch aufholen . Ausbildung und Taetigkeiten des taeglichen Lebens sind problemlos moeglich . Eine isolierte GS oder OC stellt heute keine Indikation zur Beendigung der Schwangerschaft mehr dar . In die Beratung sollte auf jeden Fall ein Kinderchirurg miteinbezogen werden .
Instructions: please typing these entity words according to sentence: Kinderchirurgie, Kinder, Gastroschisis, Komplikationen, Lebensqualitaet, Langzeitverlaeufe, Kinder, Kinder, Komplikationen, Patienten, Behandlung, Neonatologie, Diagnose, Literatur, lebensbedrohlichen, Drucksteigerung, Amnion, Silo - Technik, Nabel, Drucks, Langzeitbeobachtungen, Lebensqualitaet, Kinder, Ausbildung, Lebens, Schwangerschaft, Beratung, Kinderchirurg
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Kinderchirurgie, Kinder, Gastroschisis, Komplikationen, Lebensqualitaet, Langzeitverlaeufe, Kinder, Kinder, Komplikationen, Patienten, Behandlung, Neonatologie, Diagnose, Literatur, lebensbedrohlichen, Drucksteigerung, Amnion, Silo - Technik, Nabel, Drucks, Langzeitbeobachtungen, Lebensqualitaet, Kinder, Ausbildung, Lebens, Schwangerschaft, Beratung, Kinderchirurg | DerChirurg.00711256.ger.abstr_task2 | Sentence: Zusammenfassung . An der Klinik fuer Kinderchirurgie des Universitaetsklinikums Luebeck wurden 1970-1998 35 Kinder mit einer Omphalocele ( OC ) und 31 mit einer Gastroschisis ( GS ) operiert . 40 der 43 Ueberlebenden wurden 1990 nachuntersucht , 30 Faelle 1999 aktualisiert und 12 neue hinzugefuegt . Neben den fruehen Komplikationen wurden die Lebensqualitaet und Langzeitverlaeufe der Kinder analysiert . Der Nachuntersuchungszeitraum betrug 1-28 Jahre . 28 OCs waren groesser als 5 cm , 25 mal gelang der Direktverschluss , bei den GSs 20 mal primaer ohne Ersatzmaterial . 18 OC-Kinder bzw. 8 GS-Kinder litten unter Kombinationsfehlbildungen ; diese wurden mitversorgt . 20 % der Kinder mit OC verstarben meist aufgrund komplexer Fehlbildungen , bei den GSs 12,9 % wegen septischer Komplikationen , kombiniert mit weiteren Fehlbildungen . Nach 1990 ueberlebten alle unsere Patienten . Neben der Letalitaet waren auch die Folgeoperationen in der letzten Dekade ruecklaeufig . Fuer die verbesserten Ergebnisse sind Fortschritte der operativen Behandlung mit den medizinischen und technischen Fortschritten in der Neonatologie ursaechlich . Die Abnahme der Begleitfehlbildungen erklaert sich durch die Zunahme der praenatalen Diagnose mit konsekutiver Interruptio . Die aktuelle Literatur und unsere Ergebnisse heben die Vorteile des fruehzeitigen Primaerverschlusses hervor . Bei grossen Defekten mit der Gefahr einer lebensbedrohlichen Drucksteigerung bieten sich z . B. der Defektverschluss mit Dura und/oder Amnion oder die ( modifizierte ) Silo-Technik an . Aus kosmetischen Gruenden sollte der Nabel rekonstruiert werden . Messungen des intraabdominellen Drucks koennen in Ausnahmefaellen hilfreich eingesetzt werden . Langzeitbeobachtungen des Verlaufs und der Lebensqualitaet zeigen , dass alle Kinder mit Ausnahme derer mit schweren Begleitfehlbildungen sich normal entwickeln bzw. Rueckstaende rasch aufholen . Ausbildung und Taetigkeiten des taeglichen Lebens sind problemlos moeglich . Eine isolierte GS oder OC stellt heute keine Indikation zur Beendigung der Schwangerschaft mehr dar . In die Beratung sollte auf jeden Fall ein Kinderchirurg miteinbezogen werden .
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histamine is a compound, histamine H1 receptor is a protein | DS.d751_task0 | Sentence: During the early response in AR, histamine has been found to be the most abundant mediator and it is associated with many symptoms of this disease mediated through the histamine H1 receptor.
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histamine is a compound, histamine H1 receptor is a protein | DS.d751_task1 | Sentence: During the early response in AR, histamine has been found to be the most abundant mediator and it is associated with many symptoms of this disease mediated through the histamine H1 receptor.
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Instructions: please extract entity words from the input sentence
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Abstract is an umlsterm, aim is an umlsterm, surgery is an umlsterm, diverticulitis is an umlsterm, Methods is an umlsterm, patients is an umlsterm, classification is an umlsterm, stages is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, patients is an umlsterm, diverticulitis is an umlsterm, peritonitis is an umlsterm, stage is an umlsterm, patients is an umlsterm, stage is an umlsterm, diverticulitis is an umlsterm, Stage is an umlsterm, inflammation is an umlsterm, age is an umlsterm, patient is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, patients is an umlsterm, stage is an umlsterm, patients is an umlsterm, stage is an umlsterm, symptoms is an umlsterm, diverticulitis is an umlsterm, Prophylactic is an umlsterm, surgery is an umlsterm, abscess is an umlsterm, patients is an umlsterm, risk is an umlsterm, age is an umlsterm, surgery is an umlsterm, stage is an umlsterm | DerChirurg.00710202.eng.abstr_task0 | Sentence: Abstract . Introduction : The aim of the study was to evaluate the modern principles of surgery in diverticulitis , e . g . early elective resection and primary anastomosis . Methods : The data of 445 consecutive patients were retrospectively analysed after classifying all cases in four subgroups according to a modified Hinchey classification ( stages 0-III ) . Results : Within our study group the morbidity was 26.5 % ( n = 118 ) and the mortality was 1.6 % ( n = 7 ) . In 96 % ( n = 425 ) of all cases and in 64 % ( 21/33 ) of patients with perforated diverticulitis and peritonitis ( stage III ) , a primary anastomosis was performed . Four patients of the study group showed insufficient anastomosis ( 0.9 % ) . No leakage was observed from any of the anastomoses performed in stage III diverticulitis . Stage of inflammation and age of patient correlate with morbidity and mortality . Some 53 % ( 94/177 ) of the patients in stage II and 67 % ( 22/33 ) of the patients in stage III had never showed symptoms of diverticulitis before . Conclusion : Prophylactic surgery to avoid life-threatening situations , including abscess formation or perforation , is not possible in many cases . However , especially patients at risk ( age , coexisting illness ) should undergo early surgery . Primary anastomosis can be performed safely even at an advanced stage .
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Instructions: please typing these entity words according to sentence: Abstract, aim, surgery, diverticulitis, Methods, patients, classification, stages, morbidity, mortality, patients, diverticulitis, peritonitis, stage, patients, stage, diverticulitis, Stage, inflammation, age, patient, morbidity, mortality, patients, stage, patients, stage, symptoms, diverticulitis, Prophylactic, surgery, abscess, patients, risk, age, surgery, stage
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Abstract, aim, surgery, diverticulitis, Methods, patients, classification, stages, morbidity, mortality, patients, diverticulitis, peritonitis, stage, patients, stage, diverticulitis, Stage, inflammation, age, patient, morbidity, mortality, patients, stage, patients, stage, symptoms, diverticulitis, Prophylactic, surgery, abscess, patients, risk, age, surgery, stage | DerChirurg.00710202.eng.abstr_task2 | Sentence: Abstract . Introduction : The aim of the study was to evaluate the modern principles of surgery in diverticulitis , e . g . early elective resection and primary anastomosis . Methods : The data of 445 consecutive patients were retrospectively analysed after classifying all cases in four subgroups according to a modified Hinchey classification ( stages 0-III ) . Results : Within our study group the morbidity was 26.5 % ( n = 118 ) and the mortality was 1.6 % ( n = 7 ) . In 96 % ( n = 425 ) of all cases and in 64 % ( 21/33 ) of patients with perforated diverticulitis and peritonitis ( stage III ) , a primary anastomosis was performed . Four patients of the study group showed insufficient anastomosis ( 0.9 % ) . No leakage was observed from any of the anastomoses performed in stage III diverticulitis . Stage of inflammation and age of patient correlate with morbidity and mortality . Some 53 % ( 94/177 ) of the patients in stage II and 67 % ( 22/33 ) of the patients in stage III had never showed symptoms of diverticulitis before . Conclusion : Prophylactic surgery to avoid life-threatening situations , including abscess formation or perforation , is not possible in many cases . However , especially patients at risk ( age , coexisting illness ) should undergo early surgery . Primary anastomosis can be performed safely even at an advanced stage .
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4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile is a CHEMICAL, CDK9 is a GENE-Y | 23252711_task0 | Sentence: Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
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4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile is a CHEMICAL, CDK9 is a GENE-Y | 23252711_task1 | Sentence: Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
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cause is an umlsterm, tendon is an umlsterm, rupture is an umlsterm, microvasculature is an umlsterm, tendon is an umlsterm, injection is an umlsterm, techniques is an umlsterm, methods is an umlsterm, antibodies is an umlsterm, laminin is an umlsterm, pathogenesis is an umlsterm, tendon is an umlsterm, blood supply is an umlsterm, tendon is an umlsterm, femoral artery is an umlsterm, artery is an umlsterm, arteries is an umlsterm, Blood vessels is an umlsterm, tendon is an umlsterm, connective tissue is an umlsterm, vessels is an umlsterm, tendon is an umlsterm, distribution is an umlsterm, blood vessels is an umlsterm, tendon is an umlsterm, anterior is an umlsterm, tendon is an umlsterm, patella is an umlsterm, tendon is an umlsterm, laminin is an umlsterm, blood vessels is an umlsterm, stress is an umlsterm, tendon is an umlsterm, knee is an umlsterm, occurrence is an umlsterm, tendon is an umlsterm, joint is an umlsterm, frequency is an umlsterm | DerUnfallchirurg.91020543.eng.abstr_task1 | Sentence: Degenerative changes have been considered to be a cause for spontaneous quadriceps tendon rupture . Aim of this study is to investigate the microvasculature of the quadriceps tendon by injection techniques and immunohistochemical methods ( antibodies against laminin ) with regard to the pathogenesis of tendon degeneration . The blood supply of the quadriceps tendon arises from descending branches of the lateral circumflex femoral artery , by branches of the descending geniculate artery and by branches of the medial and lateral superior geniculate arteries . Blood vessels penetrate the tendon from the surrounding connective tissue and anastomose with a longitudinally orientated intraligamentous network . Compared to the surrounding synovial layer , the amount of vessels in the tendon substance is greatly reduced . The distribution of blood vessels within the quadriceps tendon is not homogenous . The anterior or superficial part of the tendon has a complete vascular network that extends from the musculo-tendinous junction to the patella . Within the deep portion of the quadriceps tendon there is an oval shaped avascular area which measures app . 30 mm in length and app . 15 mm in width . Within this area the immunohistochemical proof of laminin is negative . An explanation for the absence of blood vessels may be compressive stress caused by the patellar groove which serves as hypomochlion for the quadriceps tendon when the knee is flexed . The occurrence of an avascular zone within the deep layer of the tendon that is directed to the joint cavity may explain the frequency of degenerative changes in this region .
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care is an umlsterm, patient is an umlsterm, treatment is an umlsterm, tumor is an umlsterm, control is an umlsterm, compliance is an umlsterm, aim is an umlsterm, care is an umlsterm, recurrences is an umlsterm, secondary is an umlsterm, treatment is an umlsterm, patient is an umlsterm, survival is an umlsterm, quality of life is an umlsterm, anamnesis is an umlsterm | DerGynaekologe.00330489.eng.abstr_task0 | Sentence: The care of the patient after primary treatment is very important for both tumor control and patientsi compliance . The aim of this care concept should be the early detection of local recurrences so as to have better secondary treatment ( maybe cure ) options . If expensive diagnostics are needed to get this information , it is reasonable to order them . If there is no benefit for the patient , regarding survival or with respect to quality of life , clinical anamnesis and examination should be preferred .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
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] | The care of the patient after primary treatment is very important for both tumor control and patientsi compliance . The aim of this care concept should be the early detection of local recurrences so as to have better secondary treatment ( maybe cure ) options . If expensive diagnostics are needed to get this information , it is reasonable to order them . If there is no benefit for the patient , regarding survival or with respect to quality of life , clinical anamnesis and examination should be preferred . | [
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care is an umlsterm, patient is an umlsterm, treatment is an umlsterm, tumor is an umlsterm, control is an umlsterm, compliance is an umlsterm, aim is an umlsterm, care is an umlsterm, recurrences is an umlsterm, secondary is an umlsterm, treatment is an umlsterm, patient is an umlsterm, survival is an umlsterm, quality of life is an umlsterm, anamnesis is an umlsterm | DerGynaekologe.00330489.eng.abstr_task1 | Sentence: The care of the patient after primary treatment is very important for both tumor control and patientsi compliance . The aim of this care concept should be the early detection of local recurrences so as to have better secondary treatment ( maybe cure ) options . If expensive diagnostics are needed to get this information , it is reasonable to order them . If there is no benefit for the patient , regarding survival or with respect to quality of life , clinical anamnesis and examination should be preferred .
Instructions: please typing these entity words according to sentence: care, patient, treatment, tumor, control, compliance, aim, care, recurrences, secondary, treatment, patient, survival, quality of life, anamnesis
Options: umlsterm
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"O",
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] | The care of the patient after primary treatment is very important for both tumor control and patientsi compliance . The aim of this care concept should be the early detection of local recurrences so as to have better secondary treatment ( maybe cure ) options . If expensive diagnostics are needed to get this information , it is reasonable to order them . If there is no benefit for the patient , regarding survival or with respect to quality of life , clinical anamnesis and examination should be preferred . | [
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care, patient, treatment, tumor, control, compliance, aim, care, recurrences, secondary, treatment, patient, survival, quality of life, anamnesis | DerGynaekologe.00330489.eng.abstr_task2 | Sentence: The care of the patient after primary treatment is very important for both tumor control and patientsi compliance . The aim of this care concept should be the early detection of local recurrences so as to have better secondary treatment ( maybe cure ) options . If expensive diagnostics are needed to get this information , it is reasonable to order them . If there is no benefit for the patient , regarding survival or with respect to quality of life , clinical anamnesis and examination should be preferred .
Instructions: please extract entity words from the input sentence
| [
"O",
"B-umlsterm",
"O",
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] | The care of the patient after primary treatment is very important for both tumor control and patientsi compliance . The aim of this care concept should be the early detection of local recurrences so as to have better secondary treatment ( maybe cure ) options . If expensive diagnostics are needed to get this information , it is reasonable to order them . If there is no benefit for the patient , regarding survival or with respect to quality of life , clinical anamnesis and examination should be preferred . | [
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Literaturuebersicht is an umlsterm, Psychoanalyse is an umlsterm, Ich - Strukturen is an umlsterm, Angst is an umlsterm, Panikattacke is an umlsterm | ForumDerPsychoanalyse.90150237.ger.abstr_task0 | Sentence: Zusammenfassung . Eine Literaturuebersicht zum gegenwaertigen Stand der phobischen Stoerungen verdeutlicht , dass eine geschlossene Theorie dieser Krankheitsbilder in der Psychoanalyse fehlt . Waehrend in den aelteren , noch direkt auf Freud basierenden Konzepten das Konfliktmodell dominiert , gehen spaetere Autoren vermehrt von der Verarbeitung defizitaerer Ich-Strukturen im Symptom aus . Der phobische Mechanismus ist durch Verschiebung ( nach aussen und Vermeidung ) verhaeltnismaessig einheitlich bestimmt . Die primaere Angst , deren Wiederkehr gefuerchtet wird , wird entweder als neurophysiologisch begruendete Panikattacke ( Freud Aktualneurose ) : oder als Folge von Entwicklungskonflikten verstanden .
Instructions: please extract entities and their types from the input sentence, all entity types are in options
Options: umlsterm
| [
"O",
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"O",
"B-umlsterm",
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] | Zusammenfassung . Eine Literaturuebersicht zum gegenwaertigen Stand der phobischen Stoerungen verdeutlicht , dass eine geschlossene Theorie dieser Krankheitsbilder in der Psychoanalyse fehlt . Waehrend in den aelteren , noch direkt auf Freud basierenden Konzepten das Konfliktmodell dominiert , gehen spaetere Autoren vermehrt von der Verarbeitung defizitaerer Ich-Strukturen im Symptom aus . Der phobische Mechanismus ist durch Verschiebung ( nach aussen und Vermeidung ) verhaeltnismaessig einheitlich bestimmt . Die primaere Angst , deren Wiederkehr gefuerchtet wird , wird entweder als neurophysiologisch begruendete Panikattacke ( Freud Aktualneurose ) : oder als Folge von Entwicklungskonflikten verstanden . | [
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"umlsterm"
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Literaturuebersicht is an umlsterm, Psychoanalyse is an umlsterm, Ich - Strukturen is an umlsterm, Angst is an umlsterm, Panikattacke is an umlsterm | ForumDerPsychoanalyse.90150237.ger.abstr_task1 | Sentence: Zusammenfassung . Eine Literaturuebersicht zum gegenwaertigen Stand der phobischen Stoerungen verdeutlicht , dass eine geschlossene Theorie dieser Krankheitsbilder in der Psychoanalyse fehlt . Waehrend in den aelteren , noch direkt auf Freud basierenden Konzepten das Konfliktmodell dominiert , gehen spaetere Autoren vermehrt von der Verarbeitung defizitaerer Ich-Strukturen im Symptom aus . Der phobische Mechanismus ist durch Verschiebung ( nach aussen und Vermeidung ) verhaeltnismaessig einheitlich bestimmt . Die primaere Angst , deren Wiederkehr gefuerchtet wird , wird entweder als neurophysiologisch begruendete Panikattacke ( Freud Aktualneurose ) : oder als Folge von Entwicklungskonflikten verstanden .
Instructions: please typing these entity words according to sentence: Literaturuebersicht, Psychoanalyse, Ich - Strukturen, Angst, Panikattacke
Options: umlsterm
| [
"O",
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"B-umlsterm",
"O",
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Literaturuebersicht, Psychoanalyse, Ich - Strukturen, Angst, Panikattacke | ForumDerPsychoanalyse.90150237.ger.abstr_task2 | Sentence: Zusammenfassung . Eine Literaturuebersicht zum gegenwaertigen Stand der phobischen Stoerungen verdeutlicht , dass eine geschlossene Theorie dieser Krankheitsbilder in der Psychoanalyse fehlt . Waehrend in den aelteren , noch direkt auf Freud basierenden Konzepten das Konfliktmodell dominiert , gehen spaetere Autoren vermehrt von der Verarbeitung defizitaerer Ich-Strukturen im Symptom aus . Der phobische Mechanismus ist durch Verschiebung ( nach aussen und Vermeidung ) verhaeltnismaessig einheitlich bestimmt . Die primaere Angst , deren Wiederkehr gefuerchtet wird , wird entweder als neurophysiologisch begruendete Panikattacke ( Freud Aktualneurose ) : oder als Folge von Entwicklungskonflikten verstanden .
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angiotensin II - receptor blocker is a Intervention_Pharmacological, dihydropiridine calcium channel blocker is a Intervention_Pharmacological, paroxysmal atrial fibrillation with hypertension is a Participant_Condition, angiotensin II - receptor blockers ( ARB ) is a Intervention_Pharmacological, conventional calcium channel blockers ( CCB ) is a Intervention_Pharmacological, paroxysmal AF is a Outcome_Physical, Japanese Rhythm Management Trial II for Atrial Fibrillation ( J - RHYTHM II study ) is a Participant_Condition, ARB ( candesartan ) is a Intervention_Pharmacological, CCB ( amlodipine ) is a Intervention_Pharmacological, difference in AF frequency is a Outcome_Other, cardiovascular events is a Outcome_Physical, development of persistent AF is a Outcome_Physical, left atrial dimension is a Outcome_Physical, quality - of - life ( QOL ) is a Outcome_Mental, 318 is a Participant_Sample-size, 66 years is a Participant_Age, male / female is a Participant_Sex, 219/99 is a Participant_Sample-size, 158 is a Participant_Sample-size, 160 is a Participant_Sample-size, At baseline , the frequency of AF episodes ( days / month ) was 3.8 ± 5.0 in the ARB group vs . is a Participant_Condition, In patients with paroxysmal AF and hypertension is a Participant_Condition | 48560_task0 | Sentence: Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension ( J-RHYTHM II study ) . AIMS Atrial fibrillation ( AF ) is a common arrhythmia frequently associated with hypertension . This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers ( ARB ) has more beneficial effects than by conventional calcium channel blockers ( CCB ) on the frequency of paroxysmal AF with hypertension . METHODS AND RESULTS The Japanese Rhythm Management Trial II for Atrial Fibrillation ( J-RHYTHM II study ) is an open-label randomized comparison between an ARB ( candesartan ) and a CCB ( amlodipine ) in the treatment of paroxysmal AF associated with hypertension . Using daily transtelephonic monitoring , we examined asymptomatic and symptomatic paroxysmal AF episodes during a maximum 1 year treatment . The primary endpoint was the difference in AF frequency between the pre-treatment period and the final month of the follow-up . The secondary endpoints included cardiovascular events , development of persistent AF , left atrial dimension , and quality-of-life ( QOL ) . The study enrolled 318 patients ( 66 years , male/female 219/99 , 158 in the ARB group and 160 in the CCB group ) treated at 48 sites throughout Japan . At baseline , the frequency of AF episodes ( days/month ) was 3.8 ± 5.0 in the ARB group vs. 4.8 ± 6.3 in the CCB group ( not significant ) . During the follow-up , blood pressure was significantly lower in the CCB group than in the ARB group ( P < 0.001 ) . The AF frequency decreased similarly in both groups , and there was no significant difference in the primary endpoint between the two groups . There were no significant differences between the two groups in the development of persistent AF , changes in left atrial dimension , occurrence of cardiovascular events , or changes in QOL . CONCLUSIONS In patients with paroxysmal AF and hypertension , treatment of hypertension by candesartan did not have an advantage over amlodipine in the reduction in the frequency of paroxysmal AF ( umin CTR C000000427 ) .
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angiotensin II - receptor blocker is a Intervention_Pharmacological, dihydropiridine calcium channel blocker is a Intervention_Pharmacological, paroxysmal atrial fibrillation with hypertension is a Participant_Condition, angiotensin II - receptor blockers ( ARB ) is a Intervention_Pharmacological, conventional calcium channel blockers ( CCB ) is a Intervention_Pharmacological, paroxysmal AF is a Outcome_Physical, Japanese Rhythm Management Trial II for Atrial Fibrillation ( J - RHYTHM II study ) is a Participant_Condition, ARB ( candesartan ) is a Intervention_Pharmacological, CCB ( amlodipine ) is a Intervention_Pharmacological, difference in AF frequency is a Outcome_Other, cardiovascular events is a Outcome_Physical, development of persistent AF is a Outcome_Physical, left atrial dimension is a Outcome_Physical, quality - of - life ( QOL ) is a Outcome_Mental, 318 is a Participant_Sample-size, 66 years is a Participant_Age, male / female is a Participant_Sex, 219/99 is a Participant_Sample-size, 158 is a Participant_Sample-size, 160 is a Participant_Sample-size, At baseline , the frequency of AF episodes ( days / month ) was 3.8 ± 5.0 in the ARB group vs . is a Participant_Condition, In patients with paroxysmal AF and hypertension is a Participant_Condition | 48560_task1 | Sentence: Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension ( J-RHYTHM II study ) . AIMS Atrial fibrillation ( AF ) is a common arrhythmia frequently associated with hypertension . This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers ( ARB ) has more beneficial effects than by conventional calcium channel blockers ( CCB ) on the frequency of paroxysmal AF with hypertension . METHODS AND RESULTS The Japanese Rhythm Management Trial II for Atrial Fibrillation ( J-RHYTHM II study ) is an open-label randomized comparison between an ARB ( candesartan ) and a CCB ( amlodipine ) in the treatment of paroxysmal AF associated with hypertension . Using daily transtelephonic monitoring , we examined asymptomatic and symptomatic paroxysmal AF episodes during a maximum 1 year treatment . The primary endpoint was the difference in AF frequency between the pre-treatment period and the final month of the follow-up . The secondary endpoints included cardiovascular events , development of persistent AF , left atrial dimension , and quality-of-life ( QOL ) . The study enrolled 318 patients ( 66 years , male/female 219/99 , 158 in the ARB group and 160 in the CCB group ) treated at 48 sites throughout Japan . At baseline , the frequency of AF episodes ( days/month ) was 3.8 ± 5.0 in the ARB group vs. 4.8 ± 6.3 in the CCB group ( not significant ) . During the follow-up , blood pressure was significantly lower in the CCB group than in the ARB group ( P < 0.001 ) . The AF frequency decreased similarly in both groups , and there was no significant difference in the primary endpoint between the two groups . There were no significant differences between the two groups in the development of persistent AF , changes in left atrial dimension , occurrence of cardiovascular events , or changes in QOL . CONCLUSIONS In patients with paroxysmal AF and hypertension , treatment of hypertension by candesartan did not have an advantage over amlodipine in the reduction in the frequency of paroxysmal AF ( umin CTR C000000427 ) .
Instructions: please typing these entity words according to sentence: angiotensin II - receptor blocker, dihydropiridine calcium channel blocker, paroxysmal atrial fibrillation with hypertension, angiotensin II - receptor blockers ( ARB ), conventional calcium channel blockers ( CCB ), paroxysmal AF, Japanese Rhythm Management Trial II for Atrial Fibrillation ( J - RHYTHM II study ), ARB ( candesartan ), CCB ( amlodipine ), difference in AF frequency, cardiovascular events, development of persistent AF, left atrial dimension, quality - of - life ( QOL ), 318, 66 years, male / female, 219/99, 158, 160, At baseline , the frequency of AF episodes ( days / month ) was 3.8 ± 5.0 in the ARB group vs ., In patients with paroxysmal AF and hypertension
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] | Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension ( J-RHYTHM II study ) . AIMS Atrial fibrillation ( AF ) is a common arrhythmia frequently associated with hypertension . This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers ( ARB ) has more beneficial effects than by conventional calcium channel blockers ( CCB ) on the frequency of paroxysmal AF with hypertension . METHODS AND RESULTS The Japanese Rhythm Management Trial II for Atrial Fibrillation ( J-RHYTHM II study ) is an open-label randomized comparison between an ARB ( candesartan ) and a CCB ( amlodipine ) in the treatment of paroxysmal AF associated with hypertension . Using daily transtelephonic monitoring , we examined asymptomatic and symptomatic paroxysmal AF episodes during a maximum 1 year treatment . The primary endpoint was the difference in AF frequency between the pre-treatment period and the final month of the follow-up . The secondary endpoints included cardiovascular events , development of persistent AF , left atrial dimension , and quality-of-life ( QOL ) . The study enrolled 318 patients ( 66 years , male/female 219/99 , 158 in the ARB group and 160 in the CCB group ) treated at 48 sites throughout Japan . At baseline , the frequency of AF episodes ( days/month ) was 3.8 ± 5.0 in the ARB group vs. 4.8 ± 6.3 in the CCB group ( not significant ) . During the follow-up , blood pressure was significantly lower in the CCB group than in the ARB group ( P < 0.001 ) . The AF frequency decreased similarly in both groups , and there was no significant difference in the primary endpoint between the two groups . There were no significant differences between the two groups in the development of persistent AF , changes in left atrial dimension , occurrence of cardiovascular events , or changes in QOL . CONCLUSIONS In patients with paroxysmal AF and hypertension , treatment of hypertension by candesartan did not have an advantage over amlodipine in the reduction in the frequency of paroxysmal AF ( umin CTR C000000427 ) . | [
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angiotensin II - receptor blocker, dihydropiridine calcium channel blocker, paroxysmal atrial fibrillation with hypertension, angiotensin II - receptor blockers ( ARB ), conventional calcium channel blockers ( CCB ), paroxysmal AF, Japanese Rhythm Management Trial II for Atrial Fibrillation ( J - RHYTHM II study ), ARB ( candesartan ), CCB ( amlodipine ), difference in AF frequency, cardiovascular events, development of persistent AF, left atrial dimension, quality - of - life ( QOL ), 318, 66 years, male / female, 219/99, 158, 160, At baseline , the frequency of AF episodes ( days / month ) was 3.8 ± 5.0 in the ARB group vs ., In patients with paroxysmal AF and hypertension | 48560_task2 | Sentence: Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension ( J-RHYTHM II study ) . AIMS Atrial fibrillation ( AF ) is a common arrhythmia frequently associated with hypertension . This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers ( ARB ) has more beneficial effects than by conventional calcium channel blockers ( CCB ) on the frequency of paroxysmal AF with hypertension . METHODS AND RESULTS The Japanese Rhythm Management Trial II for Atrial Fibrillation ( J-RHYTHM II study ) is an open-label randomized comparison between an ARB ( candesartan ) and a CCB ( amlodipine ) in the treatment of paroxysmal AF associated with hypertension . Using daily transtelephonic monitoring , we examined asymptomatic and symptomatic paroxysmal AF episodes during a maximum 1 year treatment . The primary endpoint was the difference in AF frequency between the pre-treatment period and the final month of the follow-up . The secondary endpoints included cardiovascular events , development of persistent AF , left atrial dimension , and quality-of-life ( QOL ) . The study enrolled 318 patients ( 66 years , male/female 219/99 , 158 in the ARB group and 160 in the CCB group ) treated at 48 sites throughout Japan . At baseline , the frequency of AF episodes ( days/month ) was 3.8 ± 5.0 in the ARB group vs. 4.8 ± 6.3 in the CCB group ( not significant ) . During the follow-up , blood pressure was significantly lower in the CCB group than in the ARB group ( P < 0.001 ) . The AF frequency decreased similarly in both groups , and there was no significant difference in the primary endpoint between the two groups . There were no significant differences between the two groups in the development of persistent AF , changes in left atrial dimension , occurrence of cardiovascular events , or changes in QOL . CONCLUSIONS In patients with paroxysmal AF and hypertension , treatment of hypertension by candesartan did not have an advantage over amlodipine in the reduction in the frequency of paroxysmal AF ( umin CTR C000000427 ) .
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] | Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension ( J-RHYTHM II study ) . AIMS Atrial fibrillation ( AF ) is a common arrhythmia frequently associated with hypertension . This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers ( ARB ) has more beneficial effects than by conventional calcium channel blockers ( CCB ) on the frequency of paroxysmal AF with hypertension . METHODS AND RESULTS The Japanese Rhythm Management Trial II for Atrial Fibrillation ( J-RHYTHM II study ) is an open-label randomized comparison between an ARB ( candesartan ) and a CCB ( amlodipine ) in the treatment of paroxysmal AF associated with hypertension . Using daily transtelephonic monitoring , we examined asymptomatic and symptomatic paroxysmal AF episodes during a maximum 1 year treatment . The primary endpoint was the difference in AF frequency between the pre-treatment period and the final month of the follow-up . The secondary endpoints included cardiovascular events , development of persistent AF , left atrial dimension , and quality-of-life ( QOL ) . The study enrolled 318 patients ( 66 years , male/female 219/99 , 158 in the ARB group and 160 in the CCB group ) treated at 48 sites throughout Japan . At baseline , the frequency of AF episodes ( days/month ) was 3.8 ± 5.0 in the ARB group vs. 4.8 ± 6.3 in the CCB group ( not significant ) . During the follow-up , blood pressure was significantly lower in the CCB group than in the ARB group ( P < 0.001 ) . The AF frequency decreased similarly in both groups , and there was no significant difference in the primary endpoint between the two groups . There were no significant differences between the two groups in the development of persistent AF , changes in left atrial dimension , occurrence of cardiovascular events , or changes in QOL . CONCLUSIONS In patients with paroxysmal AF and hypertension , treatment of hypertension by candesartan did not have an advantage over amlodipine in the reduction in the frequency of paroxysmal AF ( umin CTR C000000427 ) . | [
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Sportmedizin is an umlsterm, praxisnah is an umlsterm, Grundlagenwissen is an umlsterm, Fuehrung is an umlsterm, sportmedizinisch is an umlsterm | DerOrthopaede.70260920.ger.abstr_task0 | Sentence: Der operativ taetige Orthopaede wird immer haeufiger mit Fragen der Sportmedizin aus dem Bereich der Leistungsdiagnostik bzw. Trainingslehre konfrontiert . Dieser Artikel will praxisnah das vorhandene Grundlagenwissen zusammenfassen und Leitplanken setzen zur Fuehrung eines trainingstherapeutischen Aufbauprogramms . Ein praeventiv- und sportmedizinisch relevanter Laborblock wird vorgeschlagen .
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Sportmedizin is an umlsterm, praxisnah is an umlsterm, Grundlagenwissen is an umlsterm, Fuehrung is an umlsterm, sportmedizinisch is an umlsterm | DerOrthopaede.70260920.ger.abstr_task1 | Sentence: Der operativ taetige Orthopaede wird immer haeufiger mit Fragen der Sportmedizin aus dem Bereich der Leistungsdiagnostik bzw. Trainingslehre konfrontiert . Dieser Artikel will praxisnah das vorhandene Grundlagenwissen zusammenfassen und Leitplanken setzen zur Fuehrung eines trainingstherapeutischen Aufbauprogramms . Ein praeventiv- und sportmedizinisch relevanter Laborblock wird vorgeschlagen .
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Sportmedizin, praxisnah, Grundlagenwissen, Fuehrung, sportmedizinisch | DerOrthopaede.70260920.ger.abstr_task2 | Sentence: Der operativ taetige Orthopaede wird immer haeufiger mit Fragen der Sportmedizin aus dem Bereich der Leistungsdiagnostik bzw. Trainingslehre konfrontiert . Dieser Artikel will praxisnah das vorhandene Grundlagenwissen zusammenfassen und Leitplanken setzen zur Fuehrung eines trainingstherapeutischen Aufbauprogramms . Ein praeventiv- und sportmedizinisch relevanter Laborblock wird vorgeschlagen .
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PPARgamma is a Genes & Molecular Sequences, rosiglitazone is a Chemicals & Drugs | 6990_task0 | Sentence: PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets.
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PPARgamma is a Genes & Molecular Sequences, rosiglitazone is a Chemicals & Drugs | 6990_task1 | Sentence: PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets.
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PPARgamma, rosiglitazone | 6990_task2 | Sentence: PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets.
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DNA polymerase is a GENE-N, foscarnet is a CHEMICAL, human cytomegalovirus ( HCMV ) pUL54 is a GENE-Y, DNA polymerase is a GENE-N, UL54 is a GENE-Y, foscarnet is a CHEMICAL, foscarnet is a CHEMICAL, HCMV polymerase is a GENE-N, Polymerase is a GENE-N, digoxigenin is a CHEMICAL, foscarnet is a CHEMICAL, HCMV DNA polymerases is a GENE-N, UL54 is a GENE-Y, T7 promoter is a GENE-N, UL54 is a GENE-Y, polymerases is a GENE-N, polymerases is a GENE-N, polymerases is a GENE-N, foscarnet is a CHEMICAL, V715 M is a GENE-N, T700A is a GENE-N, N495 K is a GENE-N, foscarnet is a CHEMICAL, polymerases is a GENE-N, foscarnet is a CHEMICAL | 23706_task0 | Sentence: Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet. In this study, an in-house non-isotopic method for assessing polymerase enzymatic activity in the presence and absence of foscarnet was developed and its utility for HCMV polymerase phenotyping evaluated. Polymerase activity was assessed by monitoring the incorporation of digoxigenin-labelled nucleotides into the growing DNA chain and foscarnet concentrations inhibiting enzymatic activity by 50% were determined. HCMV DNA polymerases were synthesised in vitro by expression of UL54 under the control of the T7 promoter. Mutations of interest were introduced into the wild-type UL54 gene by site-directed mutagenesis. Mutated polymerases and polymerases from HCMV reference strains were studied. The activity of polymerases containing mutations known to confer resistance to foscarnet (V715M, T700A and N495K) was inhibited by concentrations of foscarnet eight to 14 times higher than those required to inhibit wild-type polymerases. Our in-house non-radioactive phenotypic assay was sensitive and reproducible. It is also easy to perform and could provide a convenient method for characterising mutations conferring resistance to foscarnet in HCMV.
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] | Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet. In this study, an in-house non-isotopic method for assessing polymerase enzymatic activity in the presence and absence of foscarnet was developed and its utility for HCMV polymerase phenotyping evaluated. Polymerase activity was assessed by monitoring the incorporation of digoxigenin-labelled nucleotides into the growing DNA chain and foscarnet concentrations inhibiting enzymatic activity by 50% were determined. HCMV DNA polymerases were synthesised in vitro by expression of UL54 under the control of the T7 promoter. Mutations of interest were introduced into the wild-type UL54 gene by site-directed mutagenesis. Mutated polymerases and polymerases from HCMV reference strains were studied. The activity of polymerases containing mutations known to confer resistance to foscarnet (V715M, T700A and N495K) was inhibited by concentrations of foscarnet eight to 14 times higher than those required to inhibit wild-type polymerases. Our in-house non-radioactive phenotypic assay was sensitive and reproducible. It is also easy to perform and could provide a convenient method for characterising mutations conferring resistance to foscarnet in HCMV. | [
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DNA polymerase is a GENE-N, foscarnet is a CHEMICAL, human cytomegalovirus ( HCMV ) pUL54 is a GENE-Y, DNA polymerase is a GENE-N, UL54 is a GENE-Y, foscarnet is a CHEMICAL, foscarnet is a CHEMICAL, HCMV polymerase is a GENE-N, Polymerase is a GENE-N, digoxigenin is a CHEMICAL, foscarnet is a CHEMICAL, HCMV DNA polymerases is a GENE-N, UL54 is a GENE-Y, T7 promoter is a GENE-N, UL54 is a GENE-Y, polymerases is a GENE-N, polymerases is a GENE-N, polymerases is a GENE-N, foscarnet is a CHEMICAL, V715 M is a GENE-N, T700A is a GENE-N, N495 K is a GENE-N, foscarnet is a CHEMICAL, polymerases is a GENE-N, foscarnet is a CHEMICAL | 23706_task1 | Sentence: Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet. In this study, an in-house non-isotopic method for assessing polymerase enzymatic activity in the presence and absence of foscarnet was developed and its utility for HCMV polymerase phenotyping evaluated. Polymerase activity was assessed by monitoring the incorporation of digoxigenin-labelled nucleotides into the growing DNA chain and foscarnet concentrations inhibiting enzymatic activity by 50% were determined. HCMV DNA polymerases were synthesised in vitro by expression of UL54 under the control of the T7 promoter. Mutations of interest were introduced into the wild-type UL54 gene by site-directed mutagenesis. Mutated polymerases and polymerases from HCMV reference strains were studied. The activity of polymerases containing mutations known to confer resistance to foscarnet (V715M, T700A and N495K) was inhibited by concentrations of foscarnet eight to 14 times higher than those required to inhibit wild-type polymerases. Our in-house non-radioactive phenotypic assay was sensitive and reproducible. It is also easy to perform and could provide a convenient method for characterising mutations conferring resistance to foscarnet in HCMV.
Instructions: please typing these entity words according to sentence: DNA polymerase, foscarnet, human cytomegalovirus ( HCMV ) pUL54, DNA polymerase, UL54, foscarnet, foscarnet, HCMV polymerase, Polymerase, digoxigenin, foscarnet, HCMV DNA polymerases, UL54, T7 promoter, UL54, polymerases, polymerases, polymerases, foscarnet, V715 M, T700A, N495 K, foscarnet, polymerases, foscarnet
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] | Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet. In this study, an in-house non-isotopic method for assessing polymerase enzymatic activity in the presence and absence of foscarnet was developed and its utility for HCMV polymerase phenotyping evaluated. Polymerase activity was assessed by monitoring the incorporation of digoxigenin-labelled nucleotides into the growing DNA chain and foscarnet concentrations inhibiting enzymatic activity by 50% were determined. HCMV DNA polymerases were synthesised in vitro by expression of UL54 under the control of the T7 promoter. Mutations of interest were introduced into the wild-type UL54 gene by site-directed mutagenesis. Mutated polymerases and polymerases from HCMV reference strains were studied. The activity of polymerases containing mutations known to confer resistance to foscarnet (V715M, T700A and N495K) was inhibited by concentrations of foscarnet eight to 14 times higher than those required to inhibit wild-type polymerases. Our in-house non-radioactive phenotypic assay was sensitive and reproducible. It is also easy to perform and could provide a convenient method for characterising mutations conferring resistance to foscarnet in HCMV. | [
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DNA polymerase, foscarnet, human cytomegalovirus ( HCMV ) pUL54, DNA polymerase, UL54, foscarnet, foscarnet, HCMV polymerase, Polymerase, digoxigenin, foscarnet, HCMV DNA polymerases, UL54, T7 promoter, UL54, polymerases, polymerases, polymerases, foscarnet, V715 M, T700A, N495 K, foscarnet, polymerases, foscarnet | 23706_task2 | Sentence: Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet. In this study, an in-house non-isotopic method for assessing polymerase enzymatic activity in the presence and absence of foscarnet was developed and its utility for HCMV polymerase phenotyping evaluated. Polymerase activity was assessed by monitoring the incorporation of digoxigenin-labelled nucleotides into the growing DNA chain and foscarnet concentrations inhibiting enzymatic activity by 50% were determined. HCMV DNA polymerases were synthesised in vitro by expression of UL54 under the control of the T7 promoter. Mutations of interest were introduced into the wild-type UL54 gene by site-directed mutagenesis. Mutated polymerases and polymerases from HCMV reference strains were studied. The activity of polymerases containing mutations known to confer resistance to foscarnet (V715M, T700A and N495K) was inhibited by concentrations of foscarnet eight to 14 times higher than those required to inhibit wild-type polymerases. Our in-house non-radioactive phenotypic assay was sensitive and reproducible. It is also easy to perform and could provide a convenient method for characterising mutations conferring resistance to foscarnet in HCMV.
Instructions: please extract entity words from the input sentence
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] | Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet. In this study, an in-house non-isotopic method for assessing polymerase enzymatic activity in the presence and absence of foscarnet was developed and its utility for HCMV polymerase phenotyping evaluated. Polymerase activity was assessed by monitoring the incorporation of digoxigenin-labelled nucleotides into the growing DNA chain and foscarnet concentrations inhibiting enzymatic activity by 50% were determined. HCMV DNA polymerases were synthesised in vitro by expression of UL54 under the control of the T7 promoter. Mutations of interest were introduced into the wild-type UL54 gene by site-directed mutagenesis. Mutated polymerases and polymerases from HCMV reference strains were studied. The activity of polymerases containing mutations known to confer resistance to foscarnet (V715M, T700A and N495K) was inhibited by concentrations of foscarnet eight to 14 times higher than those required to inhibit wild-type polymerases. Our in-house non-radioactive phenotypic assay was sensitive and reproducible. It is also easy to perform and could provide a convenient method for characterising mutations conferring resistance to foscarnet in HCMV. | [
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Arterie is an umlsterm, Ruptur is an umlsterm, Ruptur is an umlsterm, Arteriensegment is an umlsterm, Arteriensegment is an umlsterm, Rupturzone is an umlsterm, Fingerfaenger is an umlsterm, Arteriensegment is an umlsterm, Gewebeverbund is an umlsterm, Thrombozyten is an umlsterm, Arterienruptur is an umlsterm, Fingerfaengermechanismus is an umlsterm, Stich- is an umlsterm | DerUnfallchirurg.01030722.ger.abstr_task0 | Sentence: Die historische Vorstellung , dass sich eine Arterie vom muskulaeren Typ nach Ruptur durch Intimaeinrollung " " verschliessen koenne , sollte experimentell geprueft werden . Dazu erfolgte eine Ueberdehnung von 5 Segmenten einer menschlichen A. femoralis/poplitea ( 3-4 cm lang ) bis zur kompletten Ruptur . Zudem wurde ein laengs gespaltenes Arteriensegment durch Laengszug rupturiert , ebenso ein seitlich angeschnittenes Arteriensegment . Morphologisch zeigte sich dabei eine sanduhrfoermige Einziehung der Adventitia in die Rupturzone , bedingt durch deren scherengitterartigen Aufbau . Sie dichtete wie ein Fingerfaenger die rupturierten Mediaenden ab . Bei dem laengsgespaltenen Arteriensegment konnte ein queres Zerreissen der Media zum Laengszug beobachtet werden . Auch hier liessen sich die Fasern der Adventitia extrem weit aus dem Gewebeverbund herausziehen . Weder makroskopisch noch histologisch konnten Anzeichen einer Intimaeinrollung " " gefunden werden . Im Hinblick auf die Aktivierung von Thrombozyten durch Kollagenfasern wird der spontane Blutungsstillstand nach Arterienruptur eher durch das freiliegende Adventitiakollagen induziert als durch Einrollung von Wandanteilen . Fehlt der Fingerfaengermechanismus der Adventitia wie z . B. bei Schnitt- , Stich- oder Schussverletzungen ist die Gefahr des Verblutens extrem hoch .
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] | Die historische Vorstellung , dass sich eine Arterie vom muskulaeren Typ nach Ruptur durch Intimaeinrollung " " verschliessen koenne , sollte experimentell geprueft werden . Dazu erfolgte eine Ueberdehnung von 5 Segmenten einer menschlichen A. femoralis/poplitea ( 3-4 cm lang ) bis zur kompletten Ruptur . Zudem wurde ein laengs gespaltenes Arteriensegment durch Laengszug rupturiert , ebenso ein seitlich angeschnittenes Arteriensegment . Morphologisch zeigte sich dabei eine sanduhrfoermige Einziehung der Adventitia in die Rupturzone , bedingt durch deren scherengitterartigen Aufbau . Sie dichtete wie ein Fingerfaenger die rupturierten Mediaenden ab . Bei dem laengsgespaltenen Arteriensegment konnte ein queres Zerreissen der Media zum Laengszug beobachtet werden . Auch hier liessen sich die Fasern der Adventitia extrem weit aus dem Gewebeverbund herausziehen . Weder makroskopisch noch histologisch konnten Anzeichen einer Intimaeinrollung " " gefunden werden . Im Hinblick auf die Aktivierung von Thrombozyten durch Kollagenfasern wird der spontane Blutungsstillstand nach Arterienruptur eher durch das freiliegende Adventitiakollagen induziert als durch Einrollung von Wandanteilen . Fehlt der Fingerfaengermechanismus der Adventitia wie z . B. bei Schnitt- , Stich- oder Schussverletzungen ist die Gefahr des Verblutens extrem hoch . | [
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Arterie is an umlsterm, Ruptur is an umlsterm, Ruptur is an umlsterm, Arteriensegment is an umlsterm, Arteriensegment is an umlsterm, Rupturzone is an umlsterm, Fingerfaenger is an umlsterm, Arteriensegment is an umlsterm, Gewebeverbund is an umlsterm, Thrombozyten is an umlsterm, Arterienruptur is an umlsterm, Fingerfaengermechanismus is an umlsterm, Stich- is an umlsterm | DerUnfallchirurg.01030722.ger.abstr_task1 | Sentence: Die historische Vorstellung , dass sich eine Arterie vom muskulaeren Typ nach Ruptur durch Intimaeinrollung " " verschliessen koenne , sollte experimentell geprueft werden . Dazu erfolgte eine Ueberdehnung von 5 Segmenten einer menschlichen A. femoralis/poplitea ( 3-4 cm lang ) bis zur kompletten Ruptur . Zudem wurde ein laengs gespaltenes Arteriensegment durch Laengszug rupturiert , ebenso ein seitlich angeschnittenes Arteriensegment . Morphologisch zeigte sich dabei eine sanduhrfoermige Einziehung der Adventitia in die Rupturzone , bedingt durch deren scherengitterartigen Aufbau . Sie dichtete wie ein Fingerfaenger die rupturierten Mediaenden ab . Bei dem laengsgespaltenen Arteriensegment konnte ein queres Zerreissen der Media zum Laengszug beobachtet werden . Auch hier liessen sich die Fasern der Adventitia extrem weit aus dem Gewebeverbund herausziehen . Weder makroskopisch noch histologisch konnten Anzeichen einer Intimaeinrollung " " gefunden werden . Im Hinblick auf die Aktivierung von Thrombozyten durch Kollagenfasern wird der spontane Blutungsstillstand nach Arterienruptur eher durch das freiliegende Adventitiakollagen induziert als durch Einrollung von Wandanteilen . Fehlt der Fingerfaengermechanismus der Adventitia wie z . B. bei Schnitt- , Stich- oder Schussverletzungen ist die Gefahr des Verblutens extrem hoch .
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apocalmodulin is a GENE-Y, human brain glutamic acid decarboxylase is a GENE-Y | 15686475_task0 | Sentence: Effect of apocalmodulin on recombinant human brain glutamic acid decarboxylase.
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Medical students is an umlsterm, attitudes is an umlsterm, psychiatry is an umlsterm, future is an umlsterm, care is an umlsterm, patients is an umlsterm, attitudes is an umlsterm, medical students is an umlsterm, psychiatry is an umlsterm, translation is an umlsterm, questionnaire is an umlsterm, psychiatry is an umlsterm, students is an umlsterm, psychiatrists is an umlsterm, Attitudes is an umlsterm, psychiatry is an umlsterm, Attitudes is an umlsterm, psychotherapy is an umlsterm, therapy is an umlsterm, psychiatry is an umlsterm, sex is an umlsterm, ATP is an umlsterm, students is an umlsterm, psychiatry is an umlsterm, attitudes is an umlsterm | DerNervenarzt.00710205.eng.abstr_task1 | Sentence: Medical students ' attitudes toward psychiatry are very important for the future care of psychiatric patients and the recruitment of qualified graduates . We examined the attitudes of 105 German medical students toward psychiatry using a German translation of the ATP-30, a reliable , self-administered questionnaire . In spite of a marked interest in psychiatry , most students thought it improbable that they would become psychiatrists . Attitudes toward psychiatry were generally positive ( ATP-30 score : 104.6 +/- 13.4 , where 90 represents middle , or neither positive nor negative ) but showed clear differences in some aspects . Attitudes toward psychotherapy were markedly positive , while those toward psychiatric therapy in general or the scientific basis of psychiatry were less positive . We could find no influence of sex on the ATP score , whereas students having previous experience with psychiatry showed more positive attitudes towards it .
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Medical students, attitudes, psychiatry, future, care, patients, attitudes, medical students, psychiatry, translation, questionnaire, psychiatry, students, psychiatrists, Attitudes, psychiatry, Attitudes, psychotherapy, therapy, psychiatry, sex, ATP, students, psychiatry, attitudes | DerNervenarzt.00710205.eng.abstr_task2 | Sentence: Medical students ' attitudes toward psychiatry are very important for the future care of psychiatric patients and the recruitment of qualified graduates . We examined the attitudes of 105 German medical students toward psychiatry using a German translation of the ATP-30, a reliable , self-administered questionnaire . In spite of a marked interest in psychiatry , most students thought it improbable that they would become psychiatrists . Attitudes toward psychiatry were generally positive ( ATP-30 score : 104.6 +/- 13.4 , where 90 represents middle , or neither positive nor negative ) but showed clear differences in some aspects . Attitudes toward psychotherapy were markedly positive , while those toward psychiatric therapy in general or the scientific basis of psychiatry were less positive . We could find no influence of sex on the ATP score , whereas students having previous experience with psychiatry showed more positive attitudes towards it .
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Effect is a Outcome_Physical, motivational music is a Intervention_Educational, lactate levels is a Outcome_Physical, recovery from intense exercise is a Outcome_Physical, athletes is a Participant_Condition, motivational music ( music that stimulates or inspires physical activity ) is a Intervention_Other, activity pattern is a Outcome_Physical, rate of perceived exertion ( RPE ) is a Outcome_Physical, blood lactate concentration is a Outcome_Physical, Twenty is a Participant_Sample-size, men is a Participant_Sex, mean age 26.2 ± 2.1 years is a Participant_Age | 52695_task0 | Sentence: Effect of motivational music on lactate levels during recovery from intense exercise . The effects of music played during an exercise task on athletic performance have been previously studied . Yet , these results are not applicable for competitive athletes , who can use music only during warm-up or recovery from exercise . Therefore , the aim of this study was to determine the effect of motivational music ( music that stimulates or inspires physical activity ) during recovery from intense exercise , on activity pattern , rate of perceived exertion ( RPE ) , and blood lactate concentration . Twenty young , active men ( mean age 26.2 ± 2.1 years ) performed a 6-minute run at peak oxygen consumption speed ( predetermined from the VO ( 2 ) max test ) . The mean heart rate ( HR ) , RPE , number of steps ( determined by step counter ) , and blood lactate concentrations were determined at 3 , 6 , 9 , 12 , and 15 minutes during the recovery from the exercise , with and without motivational music ( 2 separate sessions , at random order ) . There was no difference in the mean HR during the recovery with and without music . Listening to motivational music during the recovery was associated with increased voluntary activity of the participants , determined by increased number of steps ( 499.4 ± 220.1 vs. 413.2 ± 150.6 steps , with and without music , respectively ; p ≤ 0.05 ) . The increased number of steps during the recovery was accompanied by a significantly greater decrease in blood lactate concentration percentage ( 28.1 ± 12.2 vs. 22.8 ± 10.9 % , with and without music , respectively , p ≤ 0.05 ) . This was associated with a greater decrease in RPE ( 77.7 ± 14.4 vs. 73.1 ± 14.7 % with and without music , respectively ; p ≤ 0.05 ) . Our results suggest that listening to motivational music during nonstructured recovery from intense exercise leads to increased activity , faster lactate clearance , and reduced RPE and therefore may be used by athletes in their effort to enhance recovery .
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] | Effect of motivational music on lactate levels during recovery from intense exercise . The effects of music played during an exercise task on athletic performance have been previously studied . Yet , these results are not applicable for competitive athletes , who can use music only during warm-up or recovery from exercise . Therefore , the aim of this study was to determine the effect of motivational music ( music that stimulates or inspires physical activity ) during recovery from intense exercise , on activity pattern , rate of perceived exertion ( RPE ) , and blood lactate concentration . Twenty young , active men ( mean age 26.2 ± 2.1 years ) performed a 6-minute run at peak oxygen consumption speed ( predetermined from the VO ( 2 ) max test ) . The mean heart rate ( HR ) , RPE , number of steps ( determined by step counter ) , and blood lactate concentrations were determined at 3 , 6 , 9 , 12 , and 15 minutes during the recovery from the exercise , with and without motivational music ( 2 separate sessions , at random order ) . There was no difference in the mean HR during the recovery with and without music . Listening to motivational music during the recovery was associated with increased voluntary activity of the participants , determined by increased number of steps ( 499.4 ± 220.1 vs. 413.2 ± 150.6 steps , with and without music , respectively ; p ≤ 0.05 ) . The increased number of steps during the recovery was accompanied by a significantly greater decrease in blood lactate concentration percentage ( 28.1 ± 12.2 vs. 22.8 ± 10.9 % , with and without music , respectively , p ≤ 0.05 ) . This was associated with a greater decrease in RPE ( 77.7 ± 14.4 vs. 73.1 ± 14.7 % with and without music , respectively ; p ≤ 0.05 ) . Our results suggest that listening to motivational music during nonstructured recovery from intense exercise leads to increased activity , faster lactate clearance , and reduced RPE and therefore may be used by athletes in their effort to enhance recovery . | [
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Effect, motivational music, lactate levels, recovery from intense exercise, athletes, motivational music ( music that stimulates or inspires physical activity ), activity pattern, rate of perceived exertion ( RPE ), blood lactate concentration, Twenty, men, mean age 26.2 ± 2.1 years | 52695_task2 | Sentence: Effect of motivational music on lactate levels during recovery from intense exercise . The effects of music played during an exercise task on athletic performance have been previously studied . Yet , these results are not applicable for competitive athletes , who can use music only during warm-up or recovery from exercise . Therefore , the aim of this study was to determine the effect of motivational music ( music that stimulates or inspires physical activity ) during recovery from intense exercise , on activity pattern , rate of perceived exertion ( RPE ) , and blood lactate concentration . Twenty young , active men ( mean age 26.2 ± 2.1 years ) performed a 6-minute run at peak oxygen consumption speed ( predetermined from the VO ( 2 ) max test ) . The mean heart rate ( HR ) , RPE , number of steps ( determined by step counter ) , and blood lactate concentrations were determined at 3 , 6 , 9 , 12 , and 15 minutes during the recovery from the exercise , with and without motivational music ( 2 separate sessions , at random order ) . There was no difference in the mean HR during the recovery with and without music . Listening to motivational music during the recovery was associated with increased voluntary activity of the participants , determined by increased number of steps ( 499.4 ± 220.1 vs. 413.2 ± 150.6 steps , with and without music , respectively ; p ≤ 0.05 ) . The increased number of steps during the recovery was accompanied by a significantly greater decrease in blood lactate concentration percentage ( 28.1 ± 12.2 vs. 22.8 ± 10.9 % , with and without music , respectively , p ≤ 0.05 ) . This was associated with a greater decrease in RPE ( 77.7 ± 14.4 vs. 73.1 ± 14.7 % with and without music , respectively ; p ≤ 0.05 ) . Our results suggest that listening to motivational music during nonstructured recovery from intense exercise leads to increased activity , faster lactate clearance , and reduced RPE and therefore may be used by athletes in their effort to enhance recovery .
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Manidon retard is a NORMALIZABLES, Ameride is a NORMALIZABLES, Sintrom is a NORMALIZABLES, Sintrom is a NORMALIZABLES, argón is a NORMALIZABLES, argón is a NORMALIZABLES, octreótide is a NORMALIZABLES, talidomida is a NORMALIZABLES, talidomida is a NORMALIZABLES, talidomida is a NORMALIZABLES, talidomida is a NORMALIZABLES | 306_task0 | Sentence: Mujer de 73 años de edad con hipertensión arterial, artrosis de ambas caderas, leucemia linfoide crónica, meningioma del ángulo pontocerebeloso izquierdo operado, resección segmentaria de colon sigmoide por diverticulitis y peritonitis, fibrilación auricular paroxística, estenosis aórtica y cardiopatía hipertensiva que recibe tratamiento con Manidon retard®, Ameride® y Sintrom®. Presentaba numerosos episodios recidivantes de hemorragia digestiva en forma de melenas y rectorragias desde abril de 2006. No había anomalías significativas en el número o función plaquetaria. El Sintrom fue retirado en septiembre de 2006. Las hemorragias supusieron: 9 ingresos hospitalarios, 4 colonoscopias, 4 gastroscopias, 2 exploraciones con cápsula endoscópica y una enteroscopia con doble globo con acceso oral y anal. Con estas exploraciones endoscópicas se llegó a los diagnósticos de xantomas y puntos rojos petequiales de yeyuno e íleon tratados con argón, pólipo gástrico hiperplásico pequeño extirpado y pequeñas angiodisplasias en colon ascendente también tratadas con argón. La paciente recibió octreótide subcutáneo a dosis de 0,1 mg cada 12 horas que no fue bien tolerado y fue suspendido. Se desechó el tratamiento hormonal por el mayor riesgo de inducir trombosis vascular dada la enfermedad linfoproliferativa de la paciente. Pese a los tratamientos endoscópicos y médicos las hemorragias digestivas persistieron y hasta marzo de 2008 fueron necesarios 24 concentrados de hematíes. Entonces se planteó el uso de talidomida a dosis de 300 mg al día en dos tomas. Tras la valoración de la paciente por hematólogos y neurólogos y estudio con electromiograma y la explicación a la paciente de las medidas de precaución que debía tomar (en cuanto al uso personal exclusivo de la talidomida) se solicitó su uso compasivo al Ministerio de Sanidad. En los 2 primeros meses de tratamiento la paciente tuvo rectorragias ocasionales y fue necesaria la transfusión de otros 3 concentrados de hematíes. En los 4 meses posteriores no han sido necesarias nuevas transfusiones ni ingresos debidos a nuevos episodios de sangrado digestivo. La talidomida ha sido bien tolerada. Desde que recibe el tratamiento la paciente ha presentado visión borrosa debido a cataratas y edemas en miembros inferiores en relación con su cardiopatía ambos sin relación con la talidomida.
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] | Mujer de 73 años de edad con hipertensión arterial, artrosis de ambas caderas, leucemia linfoide crónica, meningioma del ángulo pontocerebeloso izquierdo operado, resección segmentaria de colon sigmoide por diverticulitis y peritonitis, fibrilación auricular paroxística, estenosis aórtica y cardiopatía hipertensiva que recibe tratamiento con Manidon retard®, Ameride® y Sintrom®. Presentaba numerosos episodios recidivantes de hemorragia digestiva en forma de melenas y rectorragias desde abril de 2006. No había anomalías significativas en el número o función plaquetaria. El Sintrom fue retirado en septiembre de 2006. Las hemorragias supusieron: 9 ingresos hospitalarios, 4 colonoscopias, 4 gastroscopias, 2 exploraciones con cápsula endoscópica y una enteroscopia con doble globo con acceso oral y anal. Con estas exploraciones endoscópicas se llegó a los diagnósticos de xantomas y puntos rojos petequiales de yeyuno e íleon tratados con argón, pólipo gástrico hiperplásico pequeño extirpado y pequeñas angiodisplasias en colon ascendente también tratadas con argón. La paciente recibió octreótide subcutáneo a dosis de 0,1 mg cada 12 horas que no fue bien tolerado y fue suspendido. Se desechó el tratamiento hormonal por el mayor riesgo de inducir trombosis vascular dada la enfermedad linfoproliferativa de la paciente. Pese a los tratamientos endoscópicos y médicos las hemorragias digestivas persistieron y hasta marzo de 2008 fueron necesarios 24 concentrados de hematíes. Entonces se planteó el uso de talidomida a dosis de 300 mg al día en dos tomas. Tras la valoración de la paciente por hematólogos y neurólogos y estudio con electromiograma y la explicación a la paciente de las medidas de precaución que debía tomar (en cuanto al uso personal exclusivo de la talidomida) se solicitó su uso compasivo al Ministerio de Sanidad. En los 2 primeros meses de tratamiento la paciente tuvo rectorragias ocasionales y fue necesaria la transfusión de otros 3 concentrados de hematíes. En los 4 meses posteriores no han sido necesarias nuevas transfusiones ni ingresos debidos a nuevos episodios de sangrado digestivo. La talidomida ha sido bien tolerada. Desde que recibe el tratamiento la paciente ha presentado visión borrosa debido a cataratas y edemas en miembros inferiores en relación con su cardiopatía ambos sin relación con la talidomida.
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Manidon retard is a NORMALIZABLES, Ameride is a NORMALIZABLES, Sintrom is a NORMALIZABLES, Sintrom is a NORMALIZABLES, argón is a NORMALIZABLES, argón is a NORMALIZABLES, octreótide is a NORMALIZABLES, talidomida is a NORMALIZABLES, talidomida is a NORMALIZABLES, talidomida is a NORMALIZABLES, talidomida is a NORMALIZABLES | 306_task1 | Sentence: Mujer de 73 años de edad con hipertensión arterial, artrosis de ambas caderas, leucemia linfoide crónica, meningioma del ángulo pontocerebeloso izquierdo operado, resección segmentaria de colon sigmoide por diverticulitis y peritonitis, fibrilación auricular paroxística, estenosis aórtica y cardiopatía hipertensiva que recibe tratamiento con Manidon retard®, Ameride® y Sintrom®. Presentaba numerosos episodios recidivantes de hemorragia digestiva en forma de melenas y rectorragias desde abril de 2006. No había anomalías significativas en el número o función plaquetaria. El Sintrom fue retirado en septiembre de 2006. Las hemorragias supusieron: 9 ingresos hospitalarios, 4 colonoscopias, 4 gastroscopias, 2 exploraciones con cápsula endoscópica y una enteroscopia con doble globo con acceso oral y anal. Con estas exploraciones endoscópicas se llegó a los diagnósticos de xantomas y puntos rojos petequiales de yeyuno e íleon tratados con argón, pólipo gástrico hiperplásico pequeño extirpado y pequeñas angiodisplasias en colon ascendente también tratadas con argón. La paciente recibió octreótide subcutáneo a dosis de 0,1 mg cada 12 horas que no fue bien tolerado y fue suspendido. Se desechó el tratamiento hormonal por el mayor riesgo de inducir trombosis vascular dada la enfermedad linfoproliferativa de la paciente. Pese a los tratamientos endoscópicos y médicos las hemorragias digestivas persistieron y hasta marzo de 2008 fueron necesarios 24 concentrados de hematíes. Entonces se planteó el uso de talidomida a dosis de 300 mg al día en dos tomas. Tras la valoración de la paciente por hematólogos y neurólogos y estudio con electromiograma y la explicación a la paciente de las medidas de precaución que debía tomar (en cuanto al uso personal exclusivo de la talidomida) se solicitó su uso compasivo al Ministerio de Sanidad. En los 2 primeros meses de tratamiento la paciente tuvo rectorragias ocasionales y fue necesaria la transfusión de otros 3 concentrados de hematíes. En los 4 meses posteriores no han sido necesarias nuevas transfusiones ni ingresos debidos a nuevos episodios de sangrado digestivo. La talidomida ha sido bien tolerada. Desde que recibe el tratamiento la paciente ha presentado visión borrosa debido a cataratas y edemas en miembros inferiores en relación con su cardiopatía ambos sin relación con la talidomida.
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Manidon retard, Ameride, Sintrom, Sintrom, argón, argón, octreótide, talidomida, talidomida, talidomida, talidomida | 306_task2 | Sentence: Mujer de 73 años de edad con hipertensión arterial, artrosis de ambas caderas, leucemia linfoide crónica, meningioma del ángulo pontocerebeloso izquierdo operado, resección segmentaria de colon sigmoide por diverticulitis y peritonitis, fibrilación auricular paroxística, estenosis aórtica y cardiopatía hipertensiva que recibe tratamiento con Manidon retard®, Ameride® y Sintrom®. Presentaba numerosos episodios recidivantes de hemorragia digestiva en forma de melenas y rectorragias desde abril de 2006. No había anomalías significativas en el número o función plaquetaria. El Sintrom fue retirado en septiembre de 2006. Las hemorragias supusieron: 9 ingresos hospitalarios, 4 colonoscopias, 4 gastroscopias, 2 exploraciones con cápsula endoscópica y una enteroscopia con doble globo con acceso oral y anal. Con estas exploraciones endoscópicas se llegó a los diagnósticos de xantomas y puntos rojos petequiales de yeyuno e íleon tratados con argón, pólipo gástrico hiperplásico pequeño extirpado y pequeñas angiodisplasias en colon ascendente también tratadas con argón. La paciente recibió octreótide subcutáneo a dosis de 0,1 mg cada 12 horas que no fue bien tolerado y fue suspendido. Se desechó el tratamiento hormonal por el mayor riesgo de inducir trombosis vascular dada la enfermedad linfoproliferativa de la paciente. Pese a los tratamientos endoscópicos y médicos las hemorragias digestivas persistieron y hasta marzo de 2008 fueron necesarios 24 concentrados de hematíes. Entonces se planteó el uso de talidomida a dosis de 300 mg al día en dos tomas. Tras la valoración de la paciente por hematólogos y neurólogos y estudio con electromiograma y la explicación a la paciente de las medidas de precaución que debía tomar (en cuanto al uso personal exclusivo de la talidomida) se solicitó su uso compasivo al Ministerio de Sanidad. En los 2 primeros meses de tratamiento la paciente tuvo rectorragias ocasionales y fue necesaria la transfusión de otros 3 concentrados de hematíes. En los 4 meses posteriores no han sido necesarias nuevas transfusiones ni ingresos debidos a nuevos episodios de sangrado digestivo. La talidomida ha sido bien tolerada. Desde que recibe el tratamiento la paciente ha presentado visión borrosa debido a cataratas y edemas en miembros inferiores en relación con su cardiopatía ambos sin relación con la talidomida.
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beta - galactoside - binding lectin is a Protein, beta - galactoside - binding lectin is a Protein, N - terminal is a Entity, lectin is a Protein | 168_task0 | Sentence: Complete amino acid sequence of 14 kDa beta-galactoside-binding lectin of chick embryo.
The complete amino acid sequence of a soluble beta-galactoside-binding lectin (subunit MW 14,500) of chick embryo was determined. The protein consists of 134 amino acids beginning with serine and ending with glutamic acid, and its N-terminal was blocked with acetate. The agreement of the present result with that obtained from nucleotide sequence analysis (Y. Ohyama et al. (1986) Biochem. Biophys. Res. Commun. 134, 51-56) indicates the lack of a cleavable leader sequence. Internal homologies were observed in several regions along the polypeptide chain. The highest homology (55% identity) was found between residues 42-58 and residues 112-128. This suggests that chick 14 kDa lectin may have evolved via several gene duplications.
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The complete amino acid sequence of a soluble beta-galactoside-binding lectin (subunit MW 14,500) of chick embryo was determined. The protein consists of 134 amino acids beginning with serine and ending with glutamic acid, and its N-terminal was blocked with acetate. The agreement of the present result with that obtained from nucleotide sequence analysis (Y. Ohyama et al. (1986) Biochem. Biophys. Res. Commun. 134, 51-56) indicates the lack of a cleavable leader sequence. Internal homologies were observed in several regions along the polypeptide chain. The highest homology (55% identity) was found between residues 42-58 and residues 112-128. This suggests that chick 14 kDa lectin may have evolved via several gene duplications. | [
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beta - galactoside - binding lectin is a Protein, beta - galactoside - binding lectin is a Protein, N - terminal is a Entity, lectin is a Protein | 168_task1 | Sentence: Complete amino acid sequence of 14 kDa beta-galactoside-binding lectin of chick embryo.
The complete amino acid sequence of a soluble beta-galactoside-binding lectin (subunit MW 14,500) of chick embryo was determined. The protein consists of 134 amino acids beginning with serine and ending with glutamic acid, and its N-terminal was blocked with acetate. The agreement of the present result with that obtained from nucleotide sequence analysis (Y. Ohyama et al. (1986) Biochem. Biophys. Res. Commun. 134, 51-56) indicates the lack of a cleavable leader sequence. Internal homologies were observed in several regions along the polypeptide chain. The highest homology (55% identity) was found between residues 42-58 and residues 112-128. This suggests that chick 14 kDa lectin may have evolved via several gene duplications.
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beta - galactoside - binding lectin, beta - galactoside - binding lectin, N - terminal, lectin | 168_task2 | Sentence: Complete amino acid sequence of 14 kDa beta-galactoside-binding lectin of chick embryo.
The complete amino acid sequence of a soluble beta-galactoside-binding lectin (subunit MW 14,500) of chick embryo was determined. The protein consists of 134 amino acids beginning with serine and ending with glutamic acid, and its N-terminal was blocked with acetate. The agreement of the present result with that obtained from nucleotide sequence analysis (Y. Ohyama et al. (1986) Biochem. Biophys. Res. Commun. 134, 51-56) indicates the lack of a cleavable leader sequence. Internal homologies were observed in several regions along the polypeptide chain. The highest homology (55% identity) was found between residues 42-58 and residues 112-128. This suggests that chick 14 kDa lectin may have evolved via several gene duplications.
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The complete amino acid sequence of a soluble beta-galactoside-binding lectin (subunit MW 14,500) of chick embryo was determined. The protein consists of 134 amino acids beginning with serine and ending with glutamic acid, and its N-terminal was blocked with acetate. The agreement of the present result with that obtained from nucleotide sequence analysis (Y. Ohyama et al. (1986) Biochem. Biophys. Res. Commun. 134, 51-56) indicates the lack of a cleavable leader sequence. Internal homologies were observed in several regions along the polypeptide chain. The highest homology (55% identity) was found between residues 42-58 and residues 112-128. This suggests that chick 14 kDa lectin may have evolved via several gene duplications. | [
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cefotaxime is a Intervention_Pharmacological, cephamandole is a Intervention_Pharmacological, post - operative infective complications following emergency abdominal surgery . is a Participant_Condition, 57 is a Participant_Sample-size, 63 is a Participant_Sample-size, Infective complications is a Outcome_Adverse-effects, Wound infections is a Outcome_Adverse-effects, 120 is a Participant_Sample-size, wound infection is a Outcome_Adverse-effects, simple , safe and effective single agent as prophylaxis for emergency abdominal surgery is a Outcome_Other | 51178_task0 | Sentence: Comparative evaluation of cefotaxime and cephamandole in the prevention of post-operative infective complications following emergency abdominal surgery . In previous published work we described 57 patients undergoing emergency abdominal surgery , prospectively randomised to receive either cefotaxime or cephamandole as a single-antibiotic , three-dose , peri-operative prophylaxis against post-operative infective complications . This earlier work suggested that cefotaxime might be more effective than cephamandole in preventing wound sepsis in emergency abdominal surgery . We describe here our findings in a further 63 patients undergoing emergency abdominal surgery who were similarly allocated into either a cefotaxime or cephamandole antibiotic group . Infective complications occurred in 12/32 ( 37 per cent ) of the cefotaxime group and 15/31 ( 48 per cent ) of the cephamandole group . Wound infections occurred in 5/32 ( 16 per cent ) of the cefotaxime group and 9/31 ( 29 per cent ) of the cephamandole group . The organisms cultured and their sensitivities are discussed in detail . The total of 120 patients studied in the two series showed wound infection to occur in 13 per cent of the 62 patients receiving cefotaxime and 30 per cent of the 58 patients receiving cephamandole . This difference reaches statistical significance ( p less than 0.05 ) . Possible mechanisms to explain this finding are discussed . Again we found the regime of 4 g of cefotaxime given peri-operatively to be a simple , safe and effective single agent as prophylaxis for emergency abdominal surgery .
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cefotaxime is a Intervention_Pharmacological, cephamandole is a Intervention_Pharmacological, post - operative infective complications following emergency abdominal surgery . is a Participant_Condition, 57 is a Participant_Sample-size, 63 is a Participant_Sample-size, Infective complications is a Outcome_Adverse-effects, Wound infections is a Outcome_Adverse-effects, 120 is a Participant_Sample-size, wound infection is a Outcome_Adverse-effects, simple , safe and effective single agent as prophylaxis for emergency abdominal surgery is a Outcome_Other | 51178_task1 | Sentence: Comparative evaluation of cefotaxime and cephamandole in the prevention of post-operative infective complications following emergency abdominal surgery . In previous published work we described 57 patients undergoing emergency abdominal surgery , prospectively randomised to receive either cefotaxime or cephamandole as a single-antibiotic , three-dose , peri-operative prophylaxis against post-operative infective complications . This earlier work suggested that cefotaxime might be more effective than cephamandole in preventing wound sepsis in emergency abdominal surgery . We describe here our findings in a further 63 patients undergoing emergency abdominal surgery who were similarly allocated into either a cefotaxime or cephamandole antibiotic group . Infective complications occurred in 12/32 ( 37 per cent ) of the cefotaxime group and 15/31 ( 48 per cent ) of the cephamandole group . Wound infections occurred in 5/32 ( 16 per cent ) of the cefotaxime group and 9/31 ( 29 per cent ) of the cephamandole group . The organisms cultured and their sensitivities are discussed in detail . The total of 120 patients studied in the two series showed wound infection to occur in 13 per cent of the 62 patients receiving cefotaxime and 30 per cent of the 58 patients receiving cephamandole . This difference reaches statistical significance ( p less than 0.05 ) . Possible mechanisms to explain this finding are discussed . Again we found the regime of 4 g of cefotaxime given peri-operatively to be a simple , safe and effective single agent as prophylaxis for emergency abdominal surgery .
Instructions: please typing these entity words according to sentence: cefotaxime, cephamandole, post - operative infective complications following emergency abdominal surgery ., 57, 63, Infective complications, Wound infections, 120, wound infection, simple , safe and effective single agent as prophylaxis for emergency abdominal surgery
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Operationstechniken is an umlsterm, Kniegelenkchirurgie is an umlsterm, Ruhigstellung is an umlsterm, Praxis is an umlsterm, Patienten is an umlsterm, Kniegelenks is an umlsterm, Gelenksteife is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm | Arthroskopie.90120268.ger.abstr_task0 | Sentence: Obwohl verfeinerte , minimalinvasive Operationstechniken sowie neue Implantate in der Kniegelenkchirurgie zumeist eine fruehfunktionelle Nachbehandlung ermoeglichen und eine langfristige Ruhigstellung vermeiden , ist man auch sicher aufgrund der steigenden Zahl an Eingriffen in der taeglichen Praxis immer wieder mit Patienten mit stoerenden Bewegungseinschraenkungen des Kniegelenks konfrontiert . Dauer und Art der Gelenksteife , Ausmass und Sitz des Bewegungshindernisses sowie Umfang der Funktionseinschraenkung indizieren zwar die jeweilige Vorgangsweise , die Indikationsstellung gestaltet sich jedoch aufgrund der Komplexitaet des pathomorphologischen Substrats der Arthrofibrose problematisch . Diese Arbeit versucht anhand der Empfehlungen anderer Autoren sowie eigener Erfahrungen nach 7 offenen Arthrolysen die Grenzen der arthroskopischen Arthrolyse bzw. die Indikation zum offenen Eingriff aufzuzeichnen . Bei den 7 Patienten wurde die Beweglichkeitsamplitude von praeoperativ durchschnittlich 42,8 Grad intraoperativ auf einen Wert von durchschnittlich 115 Grad angehoben , fiel jedoch bei der Nachuntersuchung ( im Schnitt nach 22,4 Monaten ) auf durchschnittlich 97,8 Grad zurueck .
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Operationstechniken is an umlsterm, Kniegelenkchirurgie is an umlsterm, Ruhigstellung is an umlsterm, Praxis is an umlsterm, Patienten is an umlsterm, Kniegelenks is an umlsterm, Gelenksteife is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm | Arthroskopie.90120268.ger.abstr_task1 | Sentence: Obwohl verfeinerte , minimalinvasive Operationstechniken sowie neue Implantate in der Kniegelenkchirurgie zumeist eine fruehfunktionelle Nachbehandlung ermoeglichen und eine langfristige Ruhigstellung vermeiden , ist man auch sicher aufgrund der steigenden Zahl an Eingriffen in der taeglichen Praxis immer wieder mit Patienten mit stoerenden Bewegungseinschraenkungen des Kniegelenks konfrontiert . Dauer und Art der Gelenksteife , Ausmass und Sitz des Bewegungshindernisses sowie Umfang der Funktionseinschraenkung indizieren zwar die jeweilige Vorgangsweise , die Indikationsstellung gestaltet sich jedoch aufgrund der Komplexitaet des pathomorphologischen Substrats der Arthrofibrose problematisch . Diese Arbeit versucht anhand der Empfehlungen anderer Autoren sowie eigener Erfahrungen nach 7 offenen Arthrolysen die Grenzen der arthroskopischen Arthrolyse bzw. die Indikation zum offenen Eingriff aufzuzeichnen . Bei den 7 Patienten wurde die Beweglichkeitsamplitude von praeoperativ durchschnittlich 42,8 Grad intraoperativ auf einen Wert von durchschnittlich 115 Grad angehoben , fiel jedoch bei der Nachuntersuchung ( im Schnitt nach 22,4 Monaten ) auf durchschnittlich 97,8 Grad zurueck .
Instructions: please typing these entity words according to sentence: Operationstechniken, Kniegelenkchirurgie, Ruhigstellung, Praxis, Patienten, Kniegelenks, Gelenksteife, Arbeit, Patienten
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Operationstechniken, Kniegelenkchirurgie, Ruhigstellung, Praxis, Patienten, Kniegelenks, Gelenksteife, Arbeit, Patienten | Arthroskopie.90120268.ger.abstr_task2 | Sentence: Obwohl verfeinerte , minimalinvasive Operationstechniken sowie neue Implantate in der Kniegelenkchirurgie zumeist eine fruehfunktionelle Nachbehandlung ermoeglichen und eine langfristige Ruhigstellung vermeiden , ist man auch sicher aufgrund der steigenden Zahl an Eingriffen in der taeglichen Praxis immer wieder mit Patienten mit stoerenden Bewegungseinschraenkungen des Kniegelenks konfrontiert . Dauer und Art der Gelenksteife , Ausmass und Sitz des Bewegungshindernisses sowie Umfang der Funktionseinschraenkung indizieren zwar die jeweilige Vorgangsweise , die Indikationsstellung gestaltet sich jedoch aufgrund der Komplexitaet des pathomorphologischen Substrats der Arthrofibrose problematisch . Diese Arbeit versucht anhand der Empfehlungen anderer Autoren sowie eigener Erfahrungen nach 7 offenen Arthrolysen die Grenzen der arthroskopischen Arthrolyse bzw. die Indikation zum offenen Eingriff aufzuzeichnen . Bei den 7 Patienten wurde die Beweglichkeitsamplitude von praeoperativ durchschnittlich 42,8 Grad intraoperativ auf einen Wert von durchschnittlich 115 Grad angehoben , fiel jedoch bei der Nachuntersuchung ( im Schnitt nach 22,4 Monaten ) auf durchschnittlich 97,8 Grad zurueck .
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glutamine transaminase K is a GENE-Y, GTK is a GENE-Y, sulfur is a CHEMICAL, alpha - keto acid is a CHEMICAL | 15016471_task0 | Sentence: The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.
Instructions: please extract entities and their types from the input sentence, all entity types are in options
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glutamine transaminase K is a GENE-Y, GTK is a GENE-Y, sulfur is a CHEMICAL, alpha - keto acid is a CHEMICAL | 15016471_task1 | Sentence: The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.
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glutamine transaminase K, GTK, sulfur, alpha - keto acid | 15016471_task2 | Sentence: The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.
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enamel preparation method is a Intervention_Pharmacological, marginal microleakage is a Outcome_Physical, microleakage in occlusal surfaces is a Outcome_Physical, Er : YAG laser is a Intervention_Physical, diamond - bur conventional technique is a Intervention_Physical, Thirty is a Participant_Sample-size, high - speed handpiece is a Intervention_Pharmacological, 37 % phosphoric acid is a Intervention_Pharmacological, Er : YAG laser ( 350 mJ is a Intervention_Pharmacological, Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ / cm ( 2 ) ) is a Intervention_Pharmacological, thermal cycling is a Intervention_Physical, silver nitrate solutions is a Intervention_Pharmacological, degree of leakage . is a Outcome_Physical | 27261_task0 | Sentence: Effect of enamel preparation method on in vitro marginal microleakage of a flowable composite used as pit and fissure sealant . OBJECTIVES The aim of this in vitro study was to evaluate the microleakage in occlusal surfaces , after preparation with Er : YAG laser and compared to the diamond-bur conventional technique . METHODS Thirty premolars were divided into three groups : I - high-speed handpiece + 37 % phosphoric acid ; II - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + 37 % phosphoric acid ; and III - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ/cm ( 2 ) ) . All cavities received the same adhesive system and were restored with flowable composite according to manufacturer 's instructions . Teeth were submitted to thermal cycling and immersed in 50 % silver nitrate solutions for 8 h in total darkness . Specimens were sectioned longitudinally in the bucco-lingual direction , in slices of 1 mm thick . Each slice was immersed into photo developing solution and was photographed , and microleakage was scored from 0 to 7 , by three calibrated examiners . RESULTS A statistically significant difference ( P < 0.0001 ) was observed between Er : YAG laser prepared and etched specimens and those in the other groups . CONCLUSIONS It can be concluded that no significant difference was noted between the two types of enamel preparation when etching was performed . Preparing and treating the enamel surface exclusively by Er : YAG laser resulted in the highest degree of leakage .
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] | Effect of enamel preparation method on in vitro marginal microleakage of a flowable composite used as pit and fissure sealant . OBJECTIVES The aim of this in vitro study was to evaluate the microleakage in occlusal surfaces , after preparation with Er : YAG laser and compared to the diamond-bur conventional technique . METHODS Thirty premolars were divided into three groups : I - high-speed handpiece + 37 % phosphoric acid ; II - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + 37 % phosphoric acid ; and III - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ/cm ( 2 ) ) . All cavities received the same adhesive system and were restored with flowable composite according to manufacturer 's instructions . Teeth were submitted to thermal cycling and immersed in 50 % silver nitrate solutions for 8 h in total darkness . Specimens were sectioned longitudinally in the bucco-lingual direction , in slices of 1 mm thick . Each slice was immersed into photo developing solution and was photographed , and microleakage was scored from 0 to 7 , by three calibrated examiners . RESULTS A statistically significant difference ( P < 0.0001 ) was observed between Er : YAG laser prepared and etched specimens and those in the other groups . CONCLUSIONS It can be concluded that no significant difference was noted between the two types of enamel preparation when etching was performed . Preparing and treating the enamel surface exclusively by Er : YAG laser resulted in the highest degree of leakage . | [
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"Intervention_Pharmacological",
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enamel preparation method is a Intervention_Pharmacological, marginal microleakage is a Outcome_Physical, microleakage in occlusal surfaces is a Outcome_Physical, Er : YAG laser is a Intervention_Physical, diamond - bur conventional technique is a Intervention_Physical, Thirty is a Participant_Sample-size, high - speed handpiece is a Intervention_Pharmacological, 37 % phosphoric acid is a Intervention_Pharmacological, Er : YAG laser ( 350 mJ is a Intervention_Pharmacological, Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ / cm ( 2 ) ) is a Intervention_Pharmacological, thermal cycling is a Intervention_Physical, silver nitrate solutions is a Intervention_Pharmacological, degree of leakage . is a Outcome_Physical | 27261_task1 | Sentence: Effect of enamel preparation method on in vitro marginal microleakage of a flowable composite used as pit and fissure sealant . OBJECTIVES The aim of this in vitro study was to evaluate the microleakage in occlusal surfaces , after preparation with Er : YAG laser and compared to the diamond-bur conventional technique . METHODS Thirty premolars were divided into three groups : I - high-speed handpiece + 37 % phosphoric acid ; II - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + 37 % phosphoric acid ; and III - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ/cm ( 2 ) ) . All cavities received the same adhesive system and were restored with flowable composite according to manufacturer 's instructions . Teeth were submitted to thermal cycling and immersed in 50 % silver nitrate solutions for 8 h in total darkness . Specimens were sectioned longitudinally in the bucco-lingual direction , in slices of 1 mm thick . Each slice was immersed into photo developing solution and was photographed , and microleakage was scored from 0 to 7 , by three calibrated examiners . RESULTS A statistically significant difference ( P < 0.0001 ) was observed between Er : YAG laser prepared and etched specimens and those in the other groups . CONCLUSIONS It can be concluded that no significant difference was noted between the two types of enamel preparation when etching was performed . Preparing and treating the enamel surface exclusively by Er : YAG laser resulted in the highest degree of leakage .
Instructions: please typing these entity words according to sentence: enamel preparation method, marginal microleakage, microleakage in occlusal surfaces, Er : YAG laser, diamond - bur conventional technique, Thirty, high - speed handpiece, 37 % phosphoric acid, Er : YAG laser ( 350 mJ, Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ / cm ( 2 ) ), thermal cycling, silver nitrate solutions, degree of leakage .
Options: Intervention_Physical, Intervention_Pharmacological, Outcome_Physical, Participant_Sample-size
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] | Effect of enamel preparation method on in vitro marginal microleakage of a flowable composite used as pit and fissure sealant . OBJECTIVES The aim of this in vitro study was to evaluate the microleakage in occlusal surfaces , after preparation with Er : YAG laser and compared to the diamond-bur conventional technique . METHODS Thirty premolars were divided into three groups : I - high-speed handpiece + 37 % phosphoric acid ; II - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + 37 % phosphoric acid ; and III - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ/cm ( 2 ) ) . All cavities received the same adhesive system and were restored with flowable composite according to manufacturer 's instructions . Teeth were submitted to thermal cycling and immersed in 50 % silver nitrate solutions for 8 h in total darkness . Specimens were sectioned longitudinally in the bucco-lingual direction , in slices of 1 mm thick . Each slice was immersed into photo developing solution and was photographed , and microleakage was scored from 0 to 7 , by three calibrated examiners . RESULTS A statistically significant difference ( P < 0.0001 ) was observed between Er : YAG laser prepared and etched specimens and those in the other groups . CONCLUSIONS It can be concluded that no significant difference was noted between the two types of enamel preparation when etching was performed . Preparing and treating the enamel surface exclusively by Er : YAG laser resulted in the highest degree of leakage . | [
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enamel preparation method, marginal microleakage, microleakage in occlusal surfaces, Er : YAG laser, diamond - bur conventional technique, Thirty, high - speed handpiece, 37 % phosphoric acid, Er : YAG laser ( 350 mJ, Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ / cm ( 2 ) ), thermal cycling, silver nitrate solutions, degree of leakage . | 27261_task2 | Sentence: Effect of enamel preparation method on in vitro marginal microleakage of a flowable composite used as pit and fissure sealant . OBJECTIVES The aim of this in vitro study was to evaluate the microleakage in occlusal surfaces , after preparation with Er : YAG laser and compared to the diamond-bur conventional technique . METHODS Thirty premolars were divided into three groups : I - high-speed handpiece + 37 % phosphoric acid ; II - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + 37 % phosphoric acid ; and III - Er : YAG laser ( 350 mJ , 4 Hz and 112 J/cm ( 2 ) ) + Er : YAG laser ( 80 mJ , 4 Hz , and 25 mJ/cm ( 2 ) ) . All cavities received the same adhesive system and were restored with flowable composite according to manufacturer 's instructions . Teeth were submitted to thermal cycling and immersed in 50 % silver nitrate solutions for 8 h in total darkness . Specimens were sectioned longitudinally in the bucco-lingual direction , in slices of 1 mm thick . Each slice was immersed into photo developing solution and was photographed , and microleakage was scored from 0 to 7 , by three calibrated examiners . RESULTS A statistically significant difference ( P < 0.0001 ) was observed between Er : YAG laser prepared and etched specimens and those in the other groups . CONCLUSIONS It can be concluded that no significant difference was noted between the two types of enamel preparation when etching was performed . Preparing and treating the enamel surface exclusively by Er : YAG laser resulted in the highest degree of leakage .
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autopsy is an umlsterm, mouth is an umlsterm, chest is an umlsterm, letters is an umlsterm, suicide is an umlsterm, objective is an umlsterm, historical aspects is an umlsterm, suicide is an umlsterm | Rechtsmedizin.90090112.eng.abstr_task0 | Sentence: On 21.11.1811 the poet Heinrich von Kleist and his companion Henriette Vogel were found dead in a small hollow by the Wannsee . The autopsy revealed that Kleist was shot in the mouth and Vogel died from a close-contact shot to the chest . The tragedy , which was reflected in letters and documents ended in a suicide pact . The conclusions of the pathologists were influenced by current medical opinions which were based on interpretations of the ancient humoral doctrine of Hypocrates . Subjective and objective opinions were mixed together . Some forensic and historical aspects of this suicide pact are highlighted .
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