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1001
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1002
[ "Factors", "were", "isolated", "from", "the", "nuclei", "of", "T", "cells", "that", "were", "in", "the", "induction", "phase", "of", "anergy", "or", "were", "undergoing", "activation", "." ]
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1003
[ "The", "pattern", "of", "binding", "activity", "in", "restimulated", "T", "cells", "is", "consistent", "with", "the", "pattern", "that", "has", "previously", "been", "shown", "to", "regulate", "T-cell-specific", "expression", "of", "the", "IL-2", "and", "the", "beta", "chain", "of", "the", "TcR", "genes", "." ]
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1004
[ "The", "measured", "binding", "to", "a", "TCF-1", "site", "is", "the", "same", "in", "the", "nuclei", "of", "resting", ",", "activated", ",", "and", "anergized", "cells", "." ]
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1005
[ "The", "inducible", "factors", "NK-kappa", "B", ",", "beta", "E2", ",", "CD28RC", ",", "and", "AP-1", "are", "not", "expressed", "in", "resting", "cells", "and", "are", "twofold", "lower", "in", "anergized", "as", "compared", "with", "activated", "cells", "." ]
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1006
[ "In", "contrast", ",", "anergic", "T", "cells", "express", "approximately", "eightfold", "lower", "amounts", "of", "NF-AT", ",", "a", "member", "of", "the", "class", "of", "inducible", "factors", "that", "regulates", "IL-2", "gene", "transcription", "." ]
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1007
[ "(", "ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]
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1008
[ "The", "number", "of", "glucocorticoid", "receptors", "in", "peripheral", "human", "lymphocytes", "is", "elevated", "by", "a", "zinc", "containing", "trace", "element", "preparation", "." ]
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1009
[ "A", "trace", "element", "preparation", "(", "Beres", "Drops", "Plus", ",", "BDP", ")", "elevates", "the", "number", "of", "glucocorticoid", "receptors", "(", "gcR", ")", "in", "peripheral", "lymphocytes", "isolated", "both", "from", "healthy", "blood", "donors", "and", "rheumatoid", "arthritis", "patients", "." ]
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1010
[ "This", "enhancement", "by", "BDP", "was", "found", "either", "for", "constitutive", "expression", "of", "gcRs", "or", "in", "experiments", "when", "the", "lymphocytes", "were", "stimulated", "by", "interleukin", "(", "IL", ")", "-6", "." ]
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1011
[ "There", "was", "no", "significant", "effect", "of", "BDP", "on", "IL-1", "and", "tumour", "necrosis", "factor", "alpha", "(", "TNF", "alpha", ")", "-induced", "changes", "of", "gcRs", "." ]
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1012
[ "The", "effect", "of", "BDP", "was", "greatly", "dependent", "on", "the", "presence", "of", "Zn++", "ions", "in", "the", "preparation", ",", "since", "the", "augmenting", "effect", "was", "abolished", "if", "BDP", "did", "not", "contain", "zinc", "." ]
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1013
[ "The", "DNA", "and", "steroid", "binding", "domains", "of", "the", "glucocorticoid", "receptor", "are", "not", "altered", "in", "mononuclear", "cells", "of", "treated", "CLL", "patients", "." ]
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1014
[ "The", "aim", "of", "this", "study", "was", "to", "investigate", "whether", "mutations", "in", "the", "glucocorticoid", "receptor", "could", "account", "for", "the", "increasing", "unresponsiveness", "of", "patients", "with", "chronic", "lymphatic", "leukemia", "(", "CLL", ")", "to", "combination", "chemotherapy", "." ]
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1015
[ "The", "receptor", "was", "tested", "immunocytochemically", ",", "in", "steroid", "binding", "assays", ",", "and", "by", "a", "mutation", "screening", "(", "denaturing", "gradient", "gel", "electrophoresis", ")", "of", "the", "receptor-cDNA", "." ]
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1016
[ "The", "receptor", "concentration", ",", "as", "measured", "by", "staining", "and", "steroid", "binding", "test", ",", "varied", "considerably", "but", "showed", "no", "clear", "correlation", "to", "clinical", "response", "." ]
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1017
[ "Using", "a", "highly", "sensitive", "mutation", "screening", "assay", "of", "the", "DNA-", "and", "the", "steroid-binding", "region", ",", "none", "of", "the", "treated", "patients", "revealed", "any", "mutation", ",", "suggesting", "that", "the", "glucocorticoid", "receptor", "in", "the", "CLL", "patients", "tested", "is", "not", "altered", "in", "these", "domains", "." ]
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1018
[ "In", "one", "individual", "who", "had", "not", "been", "treated", "before", "analysis", "a", "silent", "mutation", "was", "found", "in", "one", "receptor", "allele", "." ]
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1019
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1020
[ "This", "conclusion", "is", "discussed", "in", "relation", "to", "the", "mechanism", "of", "corticoid", "resistance", "in", "mouse", "and", "human", "lymphoma", "cells", "in", "culture", "." ]
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1021
[ "An", "AP1", "binding", "site", "upstream", "of", "the", "kappa", "immunoglobulin", "intron", "enhancer", "binds", "inducible", "factors", "and", "contributes", "to", "expression", "." ]
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1022
[ "Expression", "of", "the", "kappa", "immunoglobulin", "light", "chain", "gene", "requires", "developmental-", "and", "tissue-specific", "regulation", "by", "trans-acting", "factors", "which", "interact", "with", "two", "distinct", "enhancer", "elements", "." ]
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1023
[ "A", "new", "protein-DNA", "interaction", "has", "been", "identified", "upstream", "of", "the", "intron", "enhancer", ",", "within", "the", "matrix-associated", "region", "of", "the", "J-C", "intron", "." ]
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1024
[ "The", "binding", "activity", "is", "greatly", "inducible", "in", "pre-B", "cells", "by", "bacterial", "lipopolysaccharide", "and", "interleukin-1", "but", "specific", "complexes", "are", "found", "at", "all", "stages", "of", "B", "cell", "development", "tested", "." ]
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1025
[ "The", "footprinted", "binding", "site", "is", "homologous", "to", "the", "consensus", "AP1", "motif", "." ]
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1026
[ "The", "protein", "components", "of", "this", "complex", "are", "specifically", "competed", "by", "an", "AP1", "consensus", "motif", "and", "were", "shown", "by", "supershift", "to", "include", "c-Jun", "and", "c-Fos", ",", "suggesting", "that", "this", "binding", "site", "is", "an", "AP1", "motif", "and", "that", "the", "Jun", "and", "Fos", "families", "of", "transcription", "factors", "play", "a", "role", "in", "the", "regulation", "of", "the", "kappa", "light", "chain", "gene", "." ]
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1027
[ "Mutation", "of", "the", "AP1", "motif", "in", "the", "context", "of", "the", "intron", "enhancer", "was", "shown", "to", "decrease", "enhancer-mediated", "activation", "of", "the", "promoter", "in", "both", "pre-B", "cells", "induced", "with", "LPS", "and", "constitutive", "expression", "in", "mature", "B", "cells", "." ]
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1028
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1029
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1030
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1031
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1032
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1033
[ "Five", "major", "DNase-I", "hypersensitive", "sites", "(", "HS", ")", "were", "mapped", "in", "the", "tal-1", "locus", "." ]
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1034
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1035
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1036
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1037
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1038
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1039
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1040
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1041
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1042
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1043
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1044
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1045
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1046
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1047
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1048
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1049
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1050
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1051
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1052
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1053
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1054
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1055
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1059
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1060
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1062
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1063
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1064
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1065
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1066
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1067
[ "Since", "most", "B", "cell", "clones", "immortalized", "with", "EBV", "virus", "can", "be", "induced", "to", "produce", "interleukin-2", ",", "a", "typical", "T", "cell", "cytokine", ",", "we", "studied", "the", "role", "of", "different", "elements", "of", "the", "IL-2", "promoter", "in", "such", "clones", "by", "transfection", "." ]
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1068
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1069
[ "This", "element", "has", "no", "activity", "in", "T", "cells", "of", "the", "Jurkat", "line", "." ]
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1070
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1071
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1072
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1073
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1074
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1075
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1076
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1077
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1078
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1079
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1080
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1081
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1082
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1083
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1084
[ "Glucocorticoid-induced", "apoptosis", "of", "human", "leukemic", "cells", "is", "caused", "by", "the", "repressive", "function", "of", "the", "glucocorticoid", "receptor", "." ]
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1085
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1086
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1087
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1088
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1089
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1090
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1091
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1092
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1093
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1094
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1095
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1096
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1097
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1098
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1099
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1100
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