id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
1301 | [
"Interestingly",
",",
"all",
"those",
"early",
"and",
"late",
"events",
",",
"but",
"not",
"the",
"immediate",
"ones",
",",
"were",
"inhibited",
"by",
"a",
"neutralizing",
"anti-tumor",
"necrosis",
"factor",
"alpha",
"(",
"TNF-alpha",
")",
"monoclonal",
"antibody",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
0
] |
1302 | [
"Similarly",
",",
"cycloheximide",
"prevented",
"the",
"p65",
"and",
"c-rel",
"translocation",
"and",
"consequent",
"formation",
"of",
"active",
"binding",
"heterodimers",
",",
"at",
"early",
"and",
"late",
"times",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1303 | [
"Cyclosporin",
"A",
"impaired",
"not",
"only",
"early",
"and",
"late",
",",
"but",
"also",
"immediate",
"events",
";",
"however",
",",
"addition",
"of",
"TNF-alpha",
"prevented",
"all",
"inhibition",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0
] |
1304 | [
"These",
"results",
"indicate",
"that",
"the",
"regulation",
"of",
"NF-kappa",
"B",
"activation",
"during",
"T",
"cell",
"activation",
"by",
"TcR/CD3",
"signals",
"is",
"biphasic",
":",
"TcR/CD3",
"triggers",
"its",
"immediate",
"translocation",
",",
"which",
"is",
"transient",
"if",
"no",
"TNF-alpha",
"is",
"present",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
7,
8,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0
] |
1305 | [
"TNF-alpha",
",",
"therefore",
",",
"emerges",
"as",
"the",
"main",
"factor",
"responsible",
"for",
"a",
"second",
"phase",
"of",
"NF-kappa",
"B",
"regulation",
",",
"controlling",
"both",
"translocation",
"of",
"p65",
"and",
"c-rel",
",",
"and",
"new",
"mRNA",
"synthesis",
"for",
"c-rel",
"and",
"p105/p50",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
3,
0,
0,
9,
0,
9,
0
] |
1306 | [
"The",
"transcription",
"factor",
"Sp1",
"is",
"required",
"for",
"induction",
"of",
"the",
"murine",
"GM-CSF",
"promoter",
"in",
"T",
"cells",
"."
] | [
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
7,
8,
0
] |
1307 | [
"The",
"cis-acting",
"region",
",",
"GM-kappa",
"B/GC-box",
"(",
"positions",
"-95",
"and",
"-73",
")",
",",
"within",
"the",
"murine",
"GM-CSF",
"gene",
"promoter",
"is",
"required",
"for",
"maximal",
"induction",
"by",
"stimulation",
"with",
"phorbol-12-myristate",
"acetate",
"(",
"PMA",
")",
"and",
"calcium",
"ionophore",
"(",
"A23187",
")",
"in",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
1308 | [
"GM-kappa",
"B",
"defines",
"a",
"binding",
"site",
"for",
"NF-kappa",
"B",
",",
"and",
"GC-box",
"defines",
"a",
"binding",
"site",
"for",
"three",
"(",
"A1",
",",
"A2",
",",
"B",
")",
"constitutive",
"proteins",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1309 | [
"We",
"report",
"here",
"that",
"three",
"copies",
"of",
"the",
"GC-box",
"can",
"functionally",
"compensate",
"for",
"the",
"GM-kappa",
"B/GC-box",
"region",
",",
"suggesting",
"that",
"the",
"GC-motif",
"can",
"function",
"independently",
"of",
"the",
"GM-kappa",
"B",
"motif",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
1310 | [
"The",
"major",
"GC-box",
"binding",
"activity",
"A1",
"was",
"purified",
"and",
"identified",
"as",
"the",
"transcription",
"factor",
"Sp1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
1311 | [
"We",
"show",
"that",
"depletion",
"of",
"Sp1",
"(",
"A1",
")",
"from",
"nuclear",
"extracts",
"specifically",
"decreases",
"in",
"vitro",
"transcription",
"activity",
"on",
"GM-CSF",
"templates",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
1312 | [
"Since",
"the",
"human",
"GM-CSF",
"promoter",
"has",
"a",
"base",
"difference",
"within",
"the",
"GC-box",
",",
"we",
"speculate",
"that",
"this",
"may",
"explain",
"why",
"the",
"human",
"promoter",
"is",
"weak",
"and",
"that",
"an",
"upstream",
"enhancer",
"is",
"required",
"for",
"the",
"induction",
"of",
"the",
"human",
"GM-CSF",
"gene",
"."
] | [
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
1313 | [
"A",
"factor",
"that",
"regulates",
"the",
"class",
"II",
"major",
"histocompatibility",
"complex",
"gene",
"DPA",
"is",
"a",
"member",
"of",
"a",
"subfamily",
"of",
"zinc",
"finger",
"proteins",
"that",
"includes",
"a",
"Drosophila",
"developmental",
"control",
"protein",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1314 | [
"A",
"novel",
"DNA",
"sequence",
"element",
"termed",
"the",
"J",
"element",
"involved",
"in",
"the",
"regulated",
"expression",
"of",
"class",
"II",
"major",
"histocompatibility",
"complex",
"genes",
"was",
"recently",
"described",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0
] |
1315 | [
"To",
"study",
"this",
"element",
"and",
"its",
"role",
"in",
"class",
"II",
"gene",
"regulation",
"further",
",",
"a",
"cDNA",
"library",
"was",
"screened",
"with",
"oligonucleotide",
"probes",
"containing",
"both",
"the",
"S",
"element",
"and",
"the",
"nearby",
"J",
"element",
"of",
"the",
"human",
"DPA",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
1316 | [
"Several",
"DNA",
"clones",
"were",
"obtained",
"by",
"this",
"procedure",
",",
"one",
"of",
"which",
",",
"clone",
"18",
",",
"is",
"reported",
"and",
"characterized",
"here",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1317 | [
"It",
"encodes",
"a",
"protein",
"predicted",
"to",
"contain",
"688",
"amino",
"acid",
"residues",
",",
"including",
"11",
"zinc",
"finger",
"motifs",
"of",
"the",
"C2H2",
"type",
"in",
"the",
"C-terminal",
"region",
",",
"that",
"are",
"Kruppel-like",
"in",
"the",
"conservation",
"of",
"the",
"H/C",
"link",
"sequence",
"connecting",
"them",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1318 | [
"The",
"160",
"N-terminal",
"amino",
"acids",
"in",
"the",
"nonfinger",
"region",
"of",
"clone",
"18",
"are",
"highly",
"homologous",
"with",
"similar",
"regions",
"of",
"several",
"other",
"human",
",",
"mouse",
",",
"and",
"Drosophila",
"sequences",
",",
"defining",
"a",
"subfamily",
"of",
"Kruppel-like",
"zinc",
"finger",
"proteins",
"termed",
"TAB",
"(",
"tramtrack",
"[",
"ttk",
"]",
"-associated",
"box",
")",
"here",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1319 | [
"One",
"of",
"the",
"Drosophila",
"sequences",
",",
"ttk",
",",
"is",
"a",
"developmental",
"control",
"gene",
",",
"while",
"a",
"second",
"does",
"not",
"contain",
"a",
"zinc",
"finger",
"region",
"but",
"encodes",
"a",
"structure",
"important",
"in",
"oocyte",
"development",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1320 | [
"An",
"acidic",
"activation",
"domain",
"is",
"located",
"between",
"the",
"N-terminal",
"conserved",
"region",
"of",
"clone",
"18",
"and",
"its",
"zinc",
"fingers",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1321 | [
"This",
"protein",
"appears",
"to",
"require",
"both",
"the",
"S",
"and",
"J",
"elements",
",",
"which",
"are",
"separated",
"by",
"10",
"bp",
"for",
"optimal",
"binding",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1322 | [
"Antisense",
"cDNA",
"to",
"clone",
"18",
"inhibited",
"the",
"expression",
"of",
"a",
"reporter",
"construct",
"containing",
"the",
"DPA",
"promoter",
",",
"indicating",
"its",
"functional",
"importance",
"in",
"the",
"expression",
"of",
"this",
"class",
"II",
"gene",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1323 | [
"Separation",
"of",
"oxidant-initiated",
"and",
"redox-regulated",
"steps",
"in",
"the",
"NF-kappa",
"B",
"signal",
"transduction",
"pathway",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
1324 | [
"Studies",
"presented",
"here",
"show",
"that",
"overall",
"NF-kappa",
"B",
"signal",
"transduction",
"begins",
"with",
"a",
"parallel",
"series",
"of",
"stimuli-specific",
"pathways",
"through",
"which",
"cytokines",
"(",
"tumor",
"necrosis",
"factor",
"alpha",
")",
",",
"oxidants",
"(",
"hydrogen",
"peroxide",
"and",
"mitomycin",
"C",
")",
",",
"and",
"phorbol",
"ester",
"(",
"phorbol",
"12-myristate",
"13-acetate",
")",
"individually",
"initiate",
"signaling",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1325 | [
"These",
"initial",
"pathways",
"culminate",
"in",
"a",
"common",
"pathway",
"through",
"which",
"all",
"of",
"the",
"stimulating",
"agents",
"ultimately",
"signal",
"NF-kappa",
"B",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0
] |
1326 | [
"We",
"distinguish",
"the",
"stimuli-specific",
"pathways",
"by",
"showing",
"that",
"the",
"oxidative",
"stimuli",
"trigger",
"NF-kappa",
"B",
"activation",
"in",
"only",
"one",
"of",
"two",
"human",
"T-cell",
"lines",
"(",
"Wurzburg",
"but",
"not",
"Jurkat",
")",
",",
"whereas",
"tumor",
"necrosis",
"factor",
"alpha",
"and",
"phorbol",
"12-myristate",
"13-acetate",
"readily",
"stimulate",
"in",
"both",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
5,
0,
0,
5,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1327 | [
"We",
"propose",
"the",
"common",
"pathway",
"as",
"the",
"simplest",
"way",
"of",
"accounting",
"for",
"the",
"common",
"requirements",
"and",
"properties",
"of",
"the",
"signaling",
"pathway",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1328 | [
"We",
"include",
"a",
"redox-regulatory",
"mechanism",
"(",
"s",
")",
"in",
"this",
"common",
"pathway",
"to",
"account",
"for",
"the",
"previously",
"demonstrated",
"redox",
"regulation",
"of",
"NF-kappa",
"B",
"activation",
"in",
"Jurkat",
"cells",
"(",
"in",
"which",
"oxidants",
"do",
"n't",
"activate",
"NF-kappa",
"B",
")",
";",
"we",
"put",
"tyrosine",
"phosphorylation",
"in",
"the",
"common",
"pathway",
"by",
"showing",
"that",
"kinase",
"activity",
"(",
"inhibitable",
"by",
"herbimycin",
"A",
"and",
"tyrphostin",
"47",
")",
"is",
"required",
"for",
"NF-kappa",
"B",
"activation",
"by",
"all",
"stimuli",
"tested",
"in",
"both",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1329 | [
"Since",
"internal",
"sites",
"of",
"oxidant",
"production",
"have",
"been",
"shown",
"to",
"play",
"a",
"key",
"role",
"in",
"the",
"cytokine",
"-stimulated",
"activation",
"of",
"NF-kappa",
"B",
",",
"and",
"since",
"tyrosine",
"kinase",
"and",
"phosphatase",
"activities",
"are",
"known",
"to",
"be",
"altered",
"by",
"oxidants",
",",
"these",
"findings",
"suggest",
"that",
"intracellular",
"redox",
"status",
"controls",
"NF-kappa",
"B",
"activation",
"by",
"regulating",
"tyrosine",
"phosphorylation",
"event",
"(",
"s",
")",
"within",
"the",
"common",
"step",
"of",
"the",
"NF-kappa",
"B",
"signal",
"transduction",
"pathway",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
1330 | [
"Deleted",
"chromosome",
"20",
"from",
"a",
"patient",
"with",
"Alagille",
"syndrome",
"isolated",
"in",
"a",
"cell",
"hybrid",
"through",
"leucine",
"transport",
"selection",
":",
"study",
"of",
"three",
"candidate",
"genes",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1331 | [
"Alagille",
"syndrome",
"(",
"AGS",
")",
"is",
"a",
"well-defined",
"genetic",
"entity",
"assigned",
"to",
"the",
"short",
"arm",
"of",
"Chromosome",
"(",
"Chr",
")",
"20",
"by",
"a",
"series",
"of",
"observations",
"of",
"AGS",
"patients",
"associated",
"with",
"microdeletions",
"in",
"this",
"region",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1332 | [
"By",
"fusing",
"lymphoblastoid",
"cells",
"of",
"an",
"AGS",
"patient",
"that",
"exhibited",
"a",
"microdeletion",
"in",
"the",
"short",
"arm",
"of",
"Chr",
"20",
"encompassing",
"bands",
"p11.23",
"to",
"p12.3",
"with",
"rodent",
"thermosensitive",
"mutant",
"cells",
"(",
"CHOtsH1-1",
")",
"deficient",
"in-leucyl-tRNA",
"synthetase",
",",
"we",
"isolated",
"a",
"somatic",
"cell",
"hybrid",
"segregating",
"the",
"deleted",
"human",
"Chr",
"20",
"."
] | [
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
5,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
1333 | [
"This",
"hybrid",
"clone",
",",
"designated",
"NR2",
",",
"was",
"characterized",
"by",
"several",
"methods",
",",
"including",
"PCR",
",",
"with",
"eight",
"pairs",
"of",
"oligonucleotides",
"mapped",
"to",
"Chr",
"20",
":",
"D20S5",
",",
"D20S41",
",",
"D20S42",
",",
"D20S56",
",",
"D20S57",
",",
"D20S58",
",",
"adenosine",
"deaminase",
"(",
"ADA",
")",
",",
"and",
"Prion",
"protein",
"(",
"PRIP",
")",
";",
"Restriction",
"Fragment",
"Length",
"Polymorphism",
"(",
"RFLP",
")",
"analyses",
"with",
"four",
"genomic",
"anonymous",
"probes",
"(",
"D20S5",
",",
"cD3H12",
",",
"D20S17",
",",
"D20S18",
")",
";",
"and",
"fluorescent",
"in",
"situ",
"hybridization",
"(",
"FISH",
")",
"with",
"total",
"human",
"DNA",
"and",
"D20Z1",
",",
"a",
"sequence",
"specific",
"to",
"the",
"human",
"Chr",
"20",
"centromere",
",",
"as",
"probes",
"."
] | [
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0
] |
1334 | [
"The",
"NR2",
"hybrid",
"allowed",
"us",
"to",
"exclude",
"three",
"candidate",
"genes",
"for",
"AGS",
":",
"hepatic",
"nuclear",
"factor",
"3",
"beta",
"(",
"HNF3",
"beta",
")",
",",
"paired",
"box",
"1",
"(",
"PAX1",
")",
",",
"and",
"cystatin",
"C",
"(",
"CST3",
")",
"as",
"shown",
"by",
"their",
"localization",
"outside",
"of",
"the",
"deletion",
"."
] | [
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
0,
1,
2,
0,
0,
1,
2,
2,
0,
1,
0,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1335 | [
"The",
"NR2",
"hybrid",
"is",
"a",
"powerful",
"tool",
"for",
"the",
"mapping",
"of",
"new",
"probes",
"of",
"this",
"region",
",",
"as",
"well",
"as",
"for",
"obtaining",
"new",
"informative",
"probes",
"specific",
"for",
"the",
"deletion",
"by",
"subtractive",
"cloning",
"of",
"the",
"region",
"."
] | [
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1336 | [
"Such",
"markers",
"will",
"be",
"useful",
"for",
"linkage",
"analysis",
"and",
"screening",
"of",
"cDNA",
"libraries",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1337 | [
"Positive",
"and",
"negative",
"regulation",
"of",
"the",
"composite",
"octamer",
"motif",
"of",
"the",
"interleukin",
"2",
"enhancer",
"by",
"AP-1",
",",
"Oct-2",
",",
"and",
"retinoic",
"acid",
"receptor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
9,
0,
9,
0,
0,
9,
10,
10,
0
] |
1338 | [
"The",
"differentiating",
"agent",
"retinoic",
"acid",
"(",
"RA",
")",
"has",
"been",
"previously",
"reported",
"to",
"interfere",
"with",
"12-O-tetradecanoyl-phorbol-13-acetate",
"(",
"TPA",
")",
"/Ca",
"(",
"2+",
")",
"-induced",
"signals",
"for",
"the",
"regulation",
"of",
"the",
"-96",
"to",
"-66-bp",
"octamer",
"motif",
"found",
"in",
"the",
"enhancer",
"for",
"the",
"interleukin",
"(",
"IL",
")",
"-2",
"gene",
",",
"which",
"encodes",
"a",
"major",
"T",
"lymphocyte",
"growth",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1339 | [
"The",
"IL-2",
"octamer",
"motif",
"is",
"a",
"composite",
"cis-element",
"which",
"binds",
"Oct-1",
"and",
"Oct-2",
"as",
"well",
"as",
"a",
"TPA/Ca",
"(",
"2+",
")",
"-inducible",
"nuclear",
"factor",
",",
"previously",
"termed",
"octamer-associated",
"protein",
"(",
"OAP40",
")",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0
] |
1340 | [
"We",
"show",
"here",
"that",
"Oct-2",
",",
"despite",
"the",
"presence",
"of",
"an",
"active",
"transcriptional",
"activation",
"domain",
",",
"requires",
"TPA/Ca",
"(",
"2+",
")",
"-induced",
"signals",
"to",
"strongly",
"transactivate",
"the",
"IL-2",
"octamer",
"motif",
"in",
"Jurkat",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
5,
6,
6,
0
] |
1341 | [
"This",
"Oct-2",
"-dependent",
"transactivation",
"is",
"inhibited",
"by",
"RA",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
1342 | [
"The",
"presence",
"of",
"an",
"intact",
"COOH-terminal",
"domain",
"of",
"Oct-2",
"contributes",
"to",
"both",
"TPA/Ca",
"(",
"2+",
")",
"-induced",
"transactivation",
"and",
"the",
"RA-mediated",
"repression",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1343 | [
"We",
"also",
"show",
"that",
"both",
"Fos",
"and",
"Jun",
"components",
"of",
"the",
"AP-1",
"factors",
"participate",
"in",
"the",
"OAP40",
"complex",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
0
] |
1344 | [
"Furthermore",
",",
"transfected",
"c-jun",
",",
"jun-B",
",",
"jun-D",
",",
"c-fos",
",",
"or",
"Fos-B",
"expression",
"vectors",
"partially",
"substitute",
"for",
"TPA",
"and",
"Ca2+",
"and",
"cooperate",
"with",
"Oct-2",
"for",
"the",
"transactivation",
"of",
"the",
"combined",
"OAP/octamer",
"cis-element",
"."
] | [
0,
0,
0,
1,
0,
1,
0,
1,
0,
1,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
1345 | [
"Mutations",
"of",
"the",
"genuine",
"octamer-binding",
"site",
"abrogate",
"both",
"the",
"binding",
"of",
"Oct-1",
"and",
"Oct-2",
"and",
"the",
"TPA/Ca",
"(",
"2+",
")",
"-induced",
"transactivation",
"of",
"the",
"OAP/octamer",
"motif",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
1346 | [
"OAP",
"confers",
"to",
"Oct-2",
"responsivity",
"to",
"both",
"TPA/Ca2+",
"and",
"RA",
",",
"since",
"specific",
"mutations",
"of",
"the",
"AP-1/OAP-binding",
"site",
"significantly",
"reduce",
"the",
"transactivation",
"by",
"Oct-2",
"in",
"response",
"to",
"TPA",
"and",
"Ca2+",
"and",
"abolish",
"the",
"inhibition",
"by",
"RA",
"."
] | [
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1347 | [
"Furthermore",
",",
"retinoic",
"acid",
"receptor",
"(",
"RAR",
")",
"alpha",
"is",
"able",
"to",
"inhibit",
"in",
"vitro",
"the",
"formation",
"of",
"the",
"complex",
"between",
"the",
"nuclear",
"AP-1",
"/OAP",
"and",
"its",
"specific",
"binding",
"site",
",",
"resulting",
"in",
"the",
"interference",
"with",
"Oct-2",
"-dependent",
"cis-regulatory",
"function",
"of",
"this",
"AP-1",
"element",
"."
] | [
0,
0,
9,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
2,
0
] |
1348 | [
"Therefore",
",",
"we",
"propose",
"that",
"the",
"TPA/calcium-activated",
"AP-1",
"/OAP",
"element",
"is",
"the",
"main",
"target",
"of",
"positive",
"or",
"negative",
"regulatory",
"signals",
"influencing",
"the",
"IL-2",
"octamer",
"motif",
",",
"through",
"synergism",
"with",
"Oct-2",
"and",
"antagonism",
"by",
"RAR",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0
] |
1349 | [
"Missense",
"mutation",
"in",
"exon",
"7",
"of",
"the",
"common",
"gamma",
"chain",
"gene",
"causes",
"a",
"moderate",
"form",
"of",
"X-linked",
"combined",
"immunodeficiency",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1350 | [
"Clinical",
"and",
"immunologic",
"features",
"of",
"a",
"recently",
"recognized",
"X-linked",
"combined",
"immunodeficiency",
"disease",
"(",
"XCID",
")",
"suggested",
"that",
"XCID",
"and",
"X-linked",
"severe",
"combined",
"immunodeficiency",
"(",
"XSCID",
")",
"might",
"arise",
"from",
"different",
"genetic",
"defects",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1351 | [
"The",
"recent",
"discovery",
"of",
"mutations",
"in",
"the",
"common",
"gamma",
"chain",
"(",
"gamma",
"c",
")",
"gene",
",",
"a",
"constituent",
"of",
"several",
"cytokine",
"receptors",
",",
"in",
"XSCID",
"provided",
"an",
"opportunity",
"to",
"test",
"directly",
"whether",
"a",
"previously",
"unrecognized",
"mutation",
"in",
"this",
"same",
"gene",
"was",
"responsible",
"for",
"XCID",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1352 | [
"The",
"status",
"of",
"X",
"chromosome",
"inactivation",
"in",
"blood",
"leukocytes",
"from",
"obligate",
"carriers",
"of",
"XCID",
"was",
"determined",
"from",
"the",
"polymorphic",
",",
"short",
"tandem",
"repeats",
"(",
"CAG",
")",
",",
"in",
"the",
"androgen",
"receptor",
"gene",
",",
"which",
"also",
"contains",
"a",
"methylation-sensitive",
"HpaII",
"site",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
1353 | [
"As",
"in",
"XSCID",
",",
"X-chromosome",
"inactivation",
"in",
"obligate",
"carriers",
"of",
"XCID",
"was",
"nonrandom",
"in",
"T",
"and",
"B",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0
] |
1354 | [
"In",
"addition",
",",
"X",
"chromosome",
"inactivation",
"in",
"PMNs",
"was",
"variable",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] |
1355 | [
"Findings",
"from",
"this",
"analysis",
"prompted",
"sequencing",
"of",
"the",
"gamma",
"c",
"gene",
"in",
"this",
"pedigree",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0
] |
1356 | [
"A",
"missense",
"mutation",
"in",
"the",
"region",
"coding",
"for",
"the",
"cytoplasmic",
"portion",
"of",
"the",
"gamma",
"c",
"gene",
"was",
"found",
"in",
"three",
"affected",
"males",
"but",
"not",
"in",
"a",
"normal",
"brother",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1357 | [
"Therefore",
",",
"this",
"point",
"mutation",
"in",
"the",
"gamma",
"c",
"gene",
"leads",
"to",
"a",
"less",
"severe",
"degree",
"of",
"deficiency",
"in",
"cellular",
"and",
"humoral",
"immunity",
"than",
"that",
"seen",
"in",
"XSCID",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1358 | [
"Posttranscriptional",
"regulation",
"of",
"macrophage",
"tissue",
"factor",
"expression",
"by",
"antioxidants",
"."
] | [
0,
0,
0,
7,
9,
10,
0,
0,
0,
0
] |
1359 | [
"Tissue",
"factor",
"(",
"TF",
")",
"expression",
"by",
"cells",
"of",
"monocyte/macrophage",
"lineage",
"represents",
"an",
"important",
"mechanism",
"underlying",
"the",
"initiation",
"of",
"fibrin",
"deposition",
"at",
"sites",
"of",
"extravascular",
"inflammation",
"."
] | [
9,
10,
0,
9,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
1360 | [
"Recent",
"evidence",
"suggests",
"a",
"role",
"for",
"oxidant",
"stress",
"in",
"the",
"signalling",
"pathway",
"of",
"various",
"cell",
"types",
"by",
"virtue",
"of",
"its",
"ability",
"to",
"induce",
"DNA",
"binding",
"of",
"various",
"transcription",
"factors",
",",
"including",
"nuclear",
"factor",
"kappa",
"B",
"and",
"AP-1",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
9,
0
] |
1361 | [
"The",
"effect",
"of",
"antioxidant",
"treatment",
"on",
"lipopolysaccharide",
"(",
"LPS",
")",
"-induced",
"TF",
"expression",
"was",
"examined",
"in",
"murine",
"peritoneal",
"macrophages",
"and",
"human",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
7,
8,
8,
0,
7,
8,
0
] |
1362 | [
"Both",
"pyrrolidine",
"dithiocarbamate",
",",
"an",
"oxidant",
"scavenger",
",",
"and",
"N-acetyl-cysteine",
",",
"a",
"precursor",
"of",
"the",
"endogenous",
"antioxidant",
"glutathione",
",",
"inhibited",
"stimulation",
"of",
"macrophage",
"procoagulant",
"activity",
"by",
"LPS",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0
] |
1363 | [
"Northern",
"blot",
"analysis",
"showed",
"that",
"neither",
"of",
"these",
"agents",
"reduced",
"LPS-stimulated",
"TF",
"mRNA",
"accumulation",
",",
"thereby",
"suggesting",
"a",
"posttranscriptional",
"mechanism",
"for",
"the",
"effect",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1364 | [
"Immunofluorescence",
"studies",
"of",
"human",
"monocytes",
"using",
"polyclonal",
"anti-TF",
"antibody",
"showed",
"that",
"N-acetyl-cysteine",
"treatment",
"prevented",
"the",
"characteristic",
"plasmalemmal",
"localization",
"of",
"TF",
"antigen",
"that",
"occurs",
"in",
"response",
"to",
"LPS",
"."
] | [
0,
0,
0,
7,
8,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0
] |
1365 | [
"Western",
"blot",
"analysis",
"showed",
"that",
"N-acetyl-cysteine",
"reduced",
"the",
"accumulation",
"of",
"the",
"47-kD",
"mature",
"glycoprotein",
"in",
"LPS-treated",
"cells",
",",
"a",
"finding",
"consistent",
"with",
"the",
"results",
"of",
"the",
"immunofluorescence",
"studies",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1366 | [
"Furthermore",
",",
"these",
"conditions",
"did",
"not",
"result",
"in",
"an",
"accumulation",
"of",
"the",
"less",
"mature",
"forms",
"of",
"TF",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
1367 | [
"When",
"considered",
"together",
",",
"these",
"data",
"suggest",
"that",
"antioxidants",
"exert",
"their",
"effects",
"by",
"impairing",
"translation",
"and/or",
"by",
"causing",
"degradation",
"of",
"newly",
"translated",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1368 | [
"The",
"effect",
"of",
"antioxidants",
"on",
"tumor",
"necrosis",
"factor",
"appeared",
"to",
"be",
"species",
"specific",
",",
"with",
"no",
"effect",
"on",
"LPS-induced",
"tumor",
"necrosis",
"factor",
"in",
"murine",
"cells",
",",
"but",
"with",
"inhibition",
"in",
"human",
"monocytes",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
1369 | [
"The",
"posttranscriptional",
"effect",
"of",
"antioxidants",
"on",
"TF",
"expression",
"data",
"suggests",
"a",
"novel",
"mechanism",
"whereby",
"these",
"agents",
"might",
"modulate",
"monocyte",
"/macrophage",
"activation",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
1370 | [
"Characterization",
"of",
"the",
"CD48",
"gene",
"demonstrates",
"a",
"positive",
"element",
"that",
"is",
"specific",
"to",
"Epstein-Barr",
"virus-immortalized",
"B-cell",
"lines",
"and",
"contains",
"an",
"essential",
"NF-kappa",
"B",
"site",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
1,
2,
2,
0
] |
1371 | [
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"infection",
"of",
"mature",
",",
"resting",
"B",
"cells",
"drives",
"them",
"to",
"become",
"lymphoblasts",
"expressing",
"high",
"levels",
"of",
"cell",
"surface",
"molecules",
",",
"such",
"as",
"CD48",
",",
"characteristically",
"expressed",
"on",
"normal",
"activated",
"B",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
1372 | [
"Here",
",",
"we",
"report",
"on",
"the",
"identification",
"of",
"an",
"enhancer",
"element",
"in",
"the",
"CD48",
"gene",
"which",
"reproducibly",
"confers",
"strong",
"transcriptional",
"activity",
"only",
"in",
"EBV-positive",
"B-lymphoblastoid",
"cell",
"lines",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0
] |
1373 | [
"The",
"element",
"is",
"not",
"activated",
"upon",
"infection",
"of",
"established",
"EBV-negative",
"B-cell",
"lines",
",",
"indicating",
"that",
"EBV",
"fails",
"to",
"drive",
"these",
"cells",
"to",
"a",
"fully",
"lymphoblastoid",
"phenotype",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1374 | [
"An",
"NF-kappa",
"B",
"binding",
"site",
"is",
"an",
"essential",
"component",
"of",
"the",
"element",
"but",
"alone",
"is",
"not",
"sufficient",
"to",
"account",
"for",
"the",
"activity",
"or",
"the",
"specificity",
"of",
"the",
"element",
"."
] | [
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1375 | [
"We",
"have",
"detected",
"a",
"specific",
"nuclear",
"protein",
"complex",
"that",
"binds",
"to",
"the",
"element",
"and",
"show",
"that",
"NF-kappa",
"B1",
"(",
"p50",
")",
"is",
"a",
"part",
"of",
"this",
"complex",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
1376 | [
"The",
"EBV-encoded",
"latent",
"membrane",
"protein",
"1",
"is",
"capable",
"of",
"transactivating",
"the",
"isolated",
"CD48",
"NF-kappa",
"B",
"site",
"but",
"not",
"the",
"intact",
"element",
",",
"suggesting",
"that",
"the",
"latent",
"membrane",
"protein",
"1",
"-driven",
"activation",
"of",
"NF-kappa",
"B/Rel",
"must",
"interact",
"with",
"other",
"regulatory",
"pathways",
"to",
"control",
"expression",
"of",
"cellular",
"genes",
"as",
"EBV",
"drives",
"resting",
"B",
"cells",
"into",
"the",
"cell",
"cycle",
"."
] | [
0,
0,
9,
10,
10,
10,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0
] |
1377 | [
"Thapsigargin",
"induces",
"IL-2",
"receptor",
"alpha-chain",
"in",
"human",
"peripheral",
"and",
"Jurkat",
"T",
"cells",
"via",
"a",
"protein",
"kinase",
"C",
"-independent",
"mechanism",
"."
] | [
0,
0,
9,
10,
10,
0,
0,
0,
0,
5,
6,
6,
0,
0,
9,
10,
10,
0,
0,
0
] |
1378 | [
"Thapsigargin",
"(",
"TG",
")",
",",
"an",
"inhibitor",
"of",
"Ca",
"(",
"2+",
")",
"-ATPase",
",",
"depletes",
"intracellular",
"Ca2+",
"stores",
"and",
"induces",
"a",
"sustained",
"Ca2+",
"influx",
"without",
"altering",
"phosphatidyl",
"inositol",
"levels",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1379 | [
"TG",
"plus",
"phorbol",
"myristate",
"acetate",
"(",
"PMA",
")",
"but",
"not",
"TG",
"alone",
"induced",
"IL-2",
"in",
"Jurkat",
"T",
"cells",
",",
"suggesting",
"that",
"TG",
"had",
"no",
"effect",
"on",
"protein",
"kinase",
"C",
"(",
"PKC",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
1380 | [
"However",
",",
"TG",
"induced",
"increases",
"in",
"IL-2R",
"alpha",
"protein",
"as",
"well",
"as",
"IL-2R",
"alpha",
"mRNA",
"in",
"Jurkat",
"T",
"cells",
"in",
"a",
"dose-dependent",
"manner",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
3,
4,
4,
0,
5,
6,
6,
0,
0,
0,
0,
0
] |
1381 | [
"A",
"similar",
"increase",
"in",
"IL-2R",
"alpha",
"by",
"TG",
"was",
"also",
"observed",
"in",
"human",
"peripheral",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0
] |
1382 | [
"Further",
",",
"like",
"PMA",
",",
"TG",
"markedly",
"induced",
"NF",
"kappa",
"B",
"in",
"Jurkat",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
5,
6,
6,
0
] |
1383 | [
"However",
",",
"TG",
"and",
"PMA",
"exhibited",
"a",
"synergistic",
"action",
"on",
"IL-2R",
"alpha",
"expression",
",",
"suggesting",
"that",
"TG",
"and",
"PMA",
"induce",
"IL-2R",
"alpha",
"through",
"distinct",
"pathways",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0
] |
1384 | [
"PMA",
"-but",
"not",
"TG-induced",
"IL-2R",
"alpha",
"is",
"inhibited",
"by",
"the",
"PKC",
"inhibitor",
"H7",
",",
"whereas",
"TG",
"-but",
"not",
"PMA-induced",
"IL-2R",
"alpha",
"was",
"inhibited",
"by",
"cholera",
"toxin",
",",
"forskolin",
"and",
"1",
",",
"9-dideoxy",
"forskolin",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1385 | [
"In",
"toto",
",",
"these",
"results",
"suggest",
"that",
"TG",
"induces",
"IL-2R",
"alpha",
"in",
"human",
"T",
"cells",
"through",
"a",
"PKC",
"-independent",
"pathway",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
7,
8,
8,
0,
0,
9,
0,
0,
0
] |
1386 | [
"Physiological",
"concentration",
"of",
"estradiol",
"inhibits",
"polymorphonuclear",
"leukocyte",
"chemotaxis",
"via",
"a",
"receptor",
"mediated",
"system",
"."
] | [
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0
] |
1387 | [
"Estrogen",
"exhibits",
"a",
"variety",
"of",
"actions",
",",
"including",
"immuno-modulatory",
"effects",
",",
"in",
"vivo",
"and",
"in",
"vitro",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1388 | [
"The",
"mechanism",
"by",
"which",
"estrogen",
"exerts",
"its",
"anti-inflammatory",
"effect",
"is",
"not",
"yet",
"understood",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1389 | [
"We",
"investigated",
"the",
"possible",
"mechanisms",
"of",
"estradiol",
"acting",
"via",
"the",
"polymorphonuclear",
"leukocytes",
"(",
"PMNs",
")",
",",
"which",
"are",
"important",
"in",
"the",
"immune",
"response",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1390 | [
"The",
"agent",
",",
"17",
"beta-estradiol",
",",
"but",
"not",
"17",
"alpha-estradiol",
",",
"significantly",
"reduced",
"PMNs",
"chemotaxis",
"to",
"FMLP",
"in",
"a",
"dose-dependent",
"manner",
"(",
"control",
"vs",
"estrogen",
"10",
"(",
"-10",
")",
"-",
"(",
"-6",
")",
"M",
",",
"P",
"<",
"0.05",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1391 | [
"Physiological",
"concentrations",
"of",
"estradiol",
"significantly",
"reduced",
"the",
"chemotaxis",
"of",
"PMNs",
"(",
"10",
"(",
"-10",
")",
"mol",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0
] |
1392 | [
"Pre-incubation",
"with",
"clomiphene",
"or",
"tamoxifen",
"which",
"are",
"estrogen",
"receptor",
"antagonists",
",",
"eliminated",
"the",
"inhibitory",
"effect",
"of",
"17",
"beta-estradiol",
"on",
"the",
"chemotaxis",
"of",
"PMNs",
",",
"restoring",
"it",
"to",
"the",
"control",
"level",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0
] |
1393 | [
"These",
"observations",
"suggest",
"that",
"17",
"beta-estradiol",
"suppressed",
"the",
"chemotaxis",
"of",
"PMNs",
"by",
"a",
"receptor-dependent",
"mechanism",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0
] |
1394 | [
"In",
"addition",
",",
"the",
"level",
"of",
"estradiol",
"in",
"human",
"plasma",
",",
"which",
"PMNs",
"were",
"drawn",
",",
"showed",
"a",
"close",
",",
"inverse",
"correlation",
"with",
"the",
"PMNs",
"chemotaxis",
"to",
"FMLP",
"(",
"r",
"=",
"-0.821",
"p",
"<",
"0.001",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1395 | [
"Estrogen",
"may",
"modify",
"the",
"activity",
"of",
"neutrophils",
"during",
"the",
"normal",
"menstrual",
"cycle",
",",
"not",
"only",
"during",
"pregnancy",
",",
"and",
"influence",
"inflammation",
"."
] | [
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1396 | [
"Identification",
"of",
"the",
"TCL1",
"gene",
"involved",
"in",
"T-cell",
"malignancies",
"."
] | [
0,
0,
0,
1,
2,
0,
0,
7,
0,
0
] |
1397 | [
"The",
"TCL1",
"locus",
"on",
"chromosome",
"14q32.1",
"is",
"frequently",
"involved",
"in",
"chromosomal",
"translocations",
"and",
"inversions",
"with",
"one",
"of",
"the",
"T-cell",
"receptor",
"loci",
"in",
"human",
"T-cell",
"leukemias",
"and",
"lymphomas",
"."
] | [
0,
1,
2,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0
] |
1398 | [
"The",
"chromosome",
"14",
"region",
"translocated",
"or",
"rearranged",
"involves",
"approximately",
"350",
"kb",
"of",
"DNA",
"at",
"chromosome",
"band",
"14q32.1",
"."
] | [
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] |
1399 | [
"Within",
"this",
"region",
"we",
"have",
"identified",
"a",
"gene",
"coding",
"for",
"a",
"1.3-kb",
"transcript",
",",
"expressed",
"only",
"in",
"restricted",
"subsets",
"of",
"cells",
"within",
"the",
"lymphoid",
"lineage",
"and",
"expressed",
"at",
"high",
"levels",
"in",
"leukemic",
"cells",
"carrying",
"a",
"t",
"(",
"14",
";",
"14",
")",
"(",
"q11",
";",
"q32",
")",
"chromosome",
"translocation",
"or",
"a",
"inv",
"(",
"14",
")",
"(",
"q11",
";",
"q32",
")",
"chromosome",
"inversion",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
1400 | [
"The",
"cognate",
"cDNA",
"sequence",
"reveals",
"an",
"open",
"reading",
"frame",
"of",
"342",
"nt",
"encoding",
"a",
"protein",
"of",
"14",
"kDa",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |