id
stringlengths 1
5
| tokens
sequence | ner_tags
sequence |
---|---|---|
501 | [
"We",
",",
"therefore",
",",
"compared",
"the",
"activation",
"state",
"of",
"the",
"IL-2",
"gene",
"promoter",
"region",
"in",
"freshly",
"isolated",
"and",
"stimulated",
"Ipr",
"CD4-8-",
"T",
"cells",
"with",
"that",
"of",
"normal",
"T",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
7,
8,
0
] |
502 | [
"Levels",
"of",
"the",
"octamer",
",",
"NF-kappa",
"B",
"(",
"p50-p65",
"heterodimer",
")",
",",
"and",
"AP-1",
"transcriptional",
"factors",
"are",
"constitutively",
"elevated",
"in",
"freshly",
"isolated",
"Ipr",
"CD4-8-",
"T",
"cells",
",",
"consistent",
"with",
"the",
"activated",
"phenotype",
"of",
"these",
"cells",
"."
] | [
0,
0,
0,
0,
0,
9,
10,
0,
9,
10,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
503 | [
"Upon",
"stimulation",
"with",
"mitogens",
",",
"formation",
"of",
"the",
"transactivating",
"complex",
",",
"nuclear",
"factor",
"of",
"activated",
"T",
"cells",
"(",
"NF-AT",
")",
",",
"occurs",
"with",
"normal",
"kinetics",
"in",
"Ipr",
"CD4-8-",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
504 | [
"Yet",
",",
"the",
"levels",
"of",
"the",
"activating",
"NF-AT",
"complex",
"never",
"reach",
"those",
"observed",
"in",
"similarly",
"stimulated",
"normal",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
505 | [
"Furthermore",
",",
"nuclear",
"extracts",
"from",
"Ipr",
"CD4-8-",
"T",
"cells",
"display",
"high",
"levels",
"of",
"a",
"novel",
"specific",
"binding",
"activity",
"at",
"the",
"NF-AT",
"site",
",",
"which",
"is",
"present",
"at",
"much",
"lower",
"levels",
"in",
"freshly",
"isolated",
"normal",
"T",
"lymphocytes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
506 | [
"Upon",
"mitogenic",
"stimulation",
",",
"the",
"binding",
"activity",
"of",
"the",
"novel",
"NF-AT-binding",
"factor",
"is",
"rapidly",
"down-regulated",
"in",
"normal",
"T",
"cells",
",",
"but",
"persists",
"at",
"high",
"levels",
"in",
"Ipr",
"CD4-8-",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
507 | [
"These",
"two",
"abnormalities",
"at",
"the",
"NF-AT",
"site",
"provide",
"a",
"potential",
"mechanism",
"to",
"account",
"for",
"the",
"defect",
"in",
"IL-2",
"production",
"from",
"Ipr",
"CD4-8-",
"T",
"cells",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
7,
8,
0
] |
508 | [
"Cross-linking",
"of",
"CD30",
"induces",
"HIV",
"expression",
"in",
"chronically",
"infected",
"T",
"cells",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
509 | [
"CD30",
",",
"a",
"member",
"of",
"the",
"tumor",
"necrosis",
"factor",
"(",
"TNF",
")",
"receptor",
"family",
",",
"is",
"expressed",
"constitutively",
"on",
"the",
"surface",
"of",
"the",
"human",
"T",
"cell",
"line",
"ACH-2",
",",
"which",
"is",
"chronically",
"infected",
"with",
"human",
"immunodeficiency",
"virus",
"type-1",
"(",
"HIV",
")",
"-1",
"."
] | [
9,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
510 | [
"We",
"demonstrate",
"that",
"cross-linking",
"CD30",
"with",
"an",
"anti-",
"CD30",
"-specific",
"monoclonal",
"antibody",
",",
"which",
"mimics",
"the",
"described",
"biological",
"activities",
"of",
"the",
"CD30",
"ligand",
"(",
"CD30L",
")",
",",
"results",
"in",
"HIV",
"expression",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
9,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
511 | [
"CD30",
"cross-linking",
"does",
"not",
"alter",
"proliferation",
"of",
"ACH-2",
"cells",
"and",
"the",
"induction",
"of",
"HIV",
"expression",
"is",
"not",
"mediated",
"by",
"endogenous",
"TNF",
"alpha/beta",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
512 | [
"Furthermore",
",",
"cross-linking",
"of",
"CD30",
"leads",
"to",
"NF-kappa",
"B",
"activation",
"and",
"enhanced",
"HIV",
"transcription",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0
] |
513 | [
"Thus",
",",
"CD30",
"-CD30L",
"interactions",
"mediate",
"the",
"induction",
"of",
"HIV",
"expression",
"by",
"a",
"kappa",
"B-dependent",
"pathway",
"that",
"is",
"independent",
"of",
"TNF",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
514 | [
"This",
"mechanism",
"may",
"be",
"important",
"in",
"the",
"activation",
"of",
"HIV",
"expression",
"from",
"latently",
"infected",
"CD4+",
"T",
"cells",
",",
"especially",
"in",
"lymphoid",
"organs",
"where",
"cell",
"to",
"cell",
"contact",
"is",
"conducive",
"to",
"receptor-ligand",
"interactions",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
515 | [
"Human",
"MHC",
"class",
"II",
"gene",
"transcription",
"directed",
"by",
"the",
"carboxyl",
"terminus",
"of",
"CIITA",
",",
"one",
"of",
"the",
"defective",
"genes",
"in",
"type",
"II",
"MHC",
"combined",
"immune",
"deficiency",
"."
] | [
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0
] |
516 | [
"Type",
"II",
"major",
"histocompatibility",
"complex",
"combined",
"immune",
"deficiency",
"(",
"type",
"II",
"MHC",
"CID",
"or",
"bare",
"lymphocyte",
"syndrome",
")",
"is",
"a",
"congenital",
"immunodeficiency",
"disease",
"characterized",
"by",
"absent",
"MHC",
"class",
"II",
"expression",
"."
] | [
9,
10,
10,
10,
10,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0
] |
517 | [
"Four",
"distinct",
"complementation",
"groups",
"have",
"been",
"identified",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0
] |
518 | [
"Recently",
",",
"the",
"defective",
"gene",
"in",
"group",
"II",
"type",
"II",
"MHC",
"CID",
"has",
"been",
"isolated",
"and",
"termed",
"CIITA",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
9,
0
] |
519 | [
"Here",
",",
"we",
"demonstrate",
"that",
"CIITA",
"is",
"an",
"MHC",
"class",
"II",
"gene-specific",
"transcription",
"activator",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
9,
10,
10,
10,
10,
10,
0
] |
520 | [
"The",
"transcription",
"activation",
"function",
"is",
"provided",
"by",
"the",
"N-terminal",
"acidic",
"domain",
"(",
"amino",
"acids",
"26-137",
")",
",",
"which",
"is",
"experimentally",
"exchangeable",
"with",
"a",
"heterologous",
"viral",
"transcription-activating",
"domain",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
521 | [
"The",
"specificity",
"of",
"CIITA",
"for",
"three",
"major",
"MHC",
"class",
"II",
"genes",
",",
"DR",
",",
"DQ",
"and",
"DP",
",",
"is",
"mediated",
"by",
"its",
"remaining",
"C-terminal",
"residues",
"(",
"amino",
"acids",
"317-1130",
")",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
1,
2,
2,
2,
0,
1,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
522 | [
"The",
"transactivation",
"of",
"multiple",
"cis",
"elements",
",",
"especially",
"S",
"and",
"X2",
",",
"of",
"the",
"DR",
"alpha",
"proximal",
"promoter",
"in",
"group",
"II",
"CID",
"cells",
"is",
"CIITA",
"dependent",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
523 | [
"Since",
"CIITA",
"overexpression",
"in",
"normal",
"cells",
"did",
"not",
"increase",
"class",
"II",
"expression",
",",
"we",
"propose",
"that",
"initiation",
"of",
"CIITA",
"expression",
"serves",
"as",
"the",
"on-off",
"switch",
",",
"while",
"availability",
"of",
"downstream",
"interactor",
"(",
"s",
")",
"limits",
"transcription",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
524 | [
"Monocyte",
"tethering",
"by",
"P-selectin",
"regulates",
"monocyte",
"chemotactic",
"protein-1",
"and",
"tumor",
"necrosis",
"factor-alpha",
"secretion",
"."
] | [
0,
0,
0,
9,
0,
9,
10,
10,
0,
9,
10,
10,
0,
0
] |
525 | [
"Signal",
"integration",
"and",
"NF-kappa",
"B",
"translocation",
"[",
"see",
"comments",
"]"
] | [
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
526 | [
"Adhesion",
"molecules",
"that",
"tether",
"circulating",
"leukocytes",
"to",
"endothelial",
"cells",
"may",
"also",
"transduce",
"or",
"modulate",
"outside-in",
"signals",
"for",
"cellular",
"activation",
",",
"providing",
"an",
"initial",
"regulatory",
"point",
"in",
"the",
"inflammatory",
"response",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
527 | [
"Adhesion",
"of",
"human",
"monocytes",
"to",
"P-selectin",
",",
"the",
"most",
"rapidly",
"expressed",
"endothelial",
"tethering",
"factor",
",",
"increased",
"the",
"secretion",
"of",
"monocyte",
"chemotactic",
"protein-1",
"(",
"MCP-1",
")",
"and",
"tumor",
"necrosis",
"factor-alpha",
"(",
"TNF-alpha",
")",
"by",
"the",
"leukocytes",
"when",
"they",
"were",
"stimulated",
"with",
"platelet-activating",
"factor",
"."
] | [
0,
0,
7,
8,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
7,
0,
0,
0,
0,
0,
9,
10,
0
] |
528 | [
"Increased",
"cytokine",
"secretion",
"was",
"specifically",
"inhibited",
"by",
"G1",
",",
"an",
"anti-P-selectin",
"mAb",
"that",
"prevents",
"P-selectin",
"from",
"binding",
"to",
"its",
"ligand",
"(",
"P-selectin",
"glycoprotein",
"ligand-1",
")",
"on",
"myeloid",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
7,
8,
0
] |
529 | [
"Moreover",
",",
"tethering",
"by",
"P-selectin",
"specifically",
"enhanced",
"nuclear",
"translocation",
"of",
"nuclear",
"factor-kappa",
"B",
"(",
"NF-kappa",
"B",
")",
",",
"a",
"transcription",
"factor",
"required",
"for",
"expression",
"of",
"MCP-1",
",",
"TNF-alpha",
",",
"and",
"other",
"immediate-early",
"genes",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0
] |
530 | [
"These",
"results",
"demonstrate",
"that",
"P-selectin",
",",
"through",
"its",
"ligands",
"on",
"monocytes",
",",
"may",
"locally",
"regulate",
"cytokine",
"secretion",
"in",
"inflamed",
"tissues",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
531 | [
"Functional",
"roles",
"of",
"in",
"vivo",
"footprinted",
"DNA",
"motifs",
"within",
"an",
"alpha-globin",
"enhancer",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
532 | [
"Erythroid",
"lineage",
"and",
"developmental",
"stage",
"specificities",
"."
] | [
7,
8,
0,
0,
0,
0,
0
] |
533 | [
"Transcriptional",
"regulation",
"of",
"the",
"human",
"alpha-like",
"globin",
"genes",
",",
"embryonic",
"zeta",
"2",
"and",
"adult",
"alpha",
",",
"during",
"erythroid",
"development",
"is",
"mediated",
"by",
"a",
"distal",
"enhancer",
",",
"HS-40",
"."
] | [
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] |
534 | [
"Previous",
"protein-DNA",
"binding",
"studies",
"have",
"shown",
"that",
"HS-40",
"consists",
"of",
"multiple",
"nuclear",
"factor",
"binding",
"motifs",
"that",
"are",
"occupied",
"in",
"vivo",
"in",
"an",
"erythroid",
"lineage-",
"and",
"developmental",
"stage-specific",
"manner",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0
] |
535 | [
"We",
"have",
"systematically",
"analyzed",
"the",
"functional",
"roles",
"of",
"these",
"factor",
"binding",
"motifs",
"of",
"HS-40",
"by",
"site-directed",
"mutagenesis",
"and",
"transient",
"expression",
"assay",
"in",
"erythroid",
"cell",
"cultures",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0
] |
536 | [
"Three",
"of",
"these",
"HS-40",
"enhancer",
"motifs",
",",
"5'NF-E2/AP1",
",",
"GT",
"II",
",",
"and",
"GATA-1",
"(",
"c",
")",
",",
"positively",
"regulate",
"the",
"zeta",
"2-globin",
"promoter",
"activity",
"in",
"embryonic/fetal",
"erythroid",
"K562",
"cells",
"and",
"the",
"adult",
"alpha-globin",
"promoter",
"activity",
"in",
"adult",
"erythroid",
"MEL",
"cells",
"."
] | [
0,
0,
0,
1,
2,
2,
0,
1,
0,
1,
2,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
2,
2,
0,
0,
5,
6,
6,
6,
0,
0,
1,
2,
2,
0,
0,
7,
8,
8,
8,
0
] |
537 | [
"On",
"the",
"other",
"hand",
",",
"the",
"3'NF-E2/AP1",
"motif",
"is",
"able",
"to",
"exert",
"both",
"positive",
"and",
"negative",
"regulatory",
"effects",
"on",
"the",
"zeta",
"2-globin",
"promoter",
"activity",
"in",
"K562",
"cells",
",",
"and",
"this",
"dual",
"function",
"appears",
"to",
"be",
"modulated",
"through",
"differential",
"binding",
"of",
"the",
"ubiquitous",
"AP1",
"factors",
"and",
"the",
"erythroid-enriched",
"NF-E2",
"factor",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
9,
10,
0
] |
538 | [
"Mutation",
"in",
"the",
"GATA-1",
"(",
"d",
")",
"motif",
",",
"which",
"exhibits",
"an",
"adult",
"erythroid-specific",
"genomic",
"footprint",
",",
"decreases",
"the",
"HS-40",
"enhancer",
"function",
"in",
"dimethyl",
"sulfoxide-induced",
"MEL",
"cells",
"but",
"not",
"in",
"K562",
"cells",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
0,
5,
6,
0
] |
539 | [
"These",
"studies",
"have",
"defined",
"the",
"regulatory",
"roles",
"of",
"the",
"different",
"HS-40",
"motifs",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
540 | [
"The",
"remarkable",
"correlation",
"between",
"genomic",
"footprinting",
"data",
"and",
"the",
"mutagenesis",
"results",
"also",
"suggests",
"that",
"the",
"erythroid",
"lineage-",
"and",
"developmental",
"stage-specific",
"regulation",
"of",
"human",
"alpha-like",
"globin",
"promoters",
"is",
"indeed",
"modulated",
"by",
"stable",
"binding",
"of",
"specific",
"nuclear",
"factors",
"in",
"vivo",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
541 | [
"Nitric",
"oxide-stimulated",
"guanine",
"nucleotide",
"exchange",
"on",
"p21ras",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0
] |
542 | [
"The",
"protooncogene",
"p21ras",
",",
"a",
"monomeric",
"G",
"protein",
"family",
"member",
",",
"plays",
"a",
"critical",
"role",
"in",
"converting",
"extracellular",
"signals",
"into",
"intracellular",
"biochemical",
"events",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
543 | [
"Here",
",",
"we",
"report",
"that",
"nitric",
"oxide",
"(",
"NO",
")",
"activates",
"p21ras",
"in",
"human",
"T",
"cells",
"as",
"evidenced",
"by",
"an",
"increase",
"in",
"GTP-bound",
"p21ras",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
544 | [
"In",
"vitro",
"studies",
"using",
"pure",
"recombinant",
"p21ras",
"demonstrate",
"that",
"the",
"activation",
"is",
"direct",
"and",
"reversible",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
545 | [
"Circular",
"dichroism",
"analysis",
"reveals",
"that",
"NO",
"induces",
"a",
"profound",
"conformational",
"change",
"in",
"p21ras",
"in",
"association",
"with",
"GDP/GTP",
"exchange",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
546 | [
"The",
"mechanism",
"of",
"activation",
"is",
"due",
"to",
"S-nitrosylation",
"of",
"a",
"critical",
"cysteine",
"residue",
"which",
"stimulates",
"guanine",
"nucleotide",
"exchange",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
547 | [
"Furthermore",
",",
"we",
"demonstrate",
"that",
"p21ras",
"is",
"essential",
"for",
"NO-induced",
"downstream",
"signaling",
",",
"such",
"as",
"NF-kappa",
"B",
"activation",
",",
"and",
"that",
"endogenous",
"NO",
"can",
"activate",
"p21ras",
"in",
"the",
"same",
"cell",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0
] |
548 | [
"These",
"studies",
"identify",
"p21ras",
"as",
"a",
"target",
"of",
"the",
"same",
"cell",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
549 | [
"These",
"studies",
"identify",
"p21ras",
"as",
"a",
"target",
"of",
"NO",
"in",
"T",
"cells",
"and",
"suggest",
"that",
"NO",
"activates",
"p21ras",
"by",
"an",
"action",
"which",
"mimics",
"that",
"of",
"guanine",
"nucleotide",
"exchange",
"factors",
"."
] | [
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0
] |
550 | [
"Interleukin-2",
"promoter",
"activity",
"in",
"Epstein-Barr",
"virus-transformed",
"B",
"lymphocytes",
"is",
"controlled",
"by",
"nuclear",
"factor-chi",
"B",
"."
] | [
1,
2,
0,
0,
0,
0,
7,
8,
0,
0,
0,
9,
10,
10,
0
] |
551 | [
"The",
"regulation",
"of",
"interleukin",
"(",
"IL",
")",
"-2",
"gene",
"expression",
"has",
"been",
"investigated",
"mainly",
"in",
"T",
"lymphocytes",
",",
"the",
"predominant",
"producers",
"of",
"IL-2",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
9,
0
] |
552 | [
"However",
",",
"B",
"cells",
"can",
"also",
"synthesize",
"IL-2",
"."
] | [
0,
0,
7,
8,
0,
0,
0,
9,
0
] |
553 | [
"In",
"the",
"present",
"study",
"we",
"analyzed",
"the",
"control",
"of",
"IL-2",
"promoter",
"activity",
"in",
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"-transformed",
"B",
"cell",
"clones",
"which",
"are",
"capable",
"of",
"secreting",
"IL-2",
"at",
"a",
"low",
"level",
"after",
"stimulation",
"with",
"phorbol",
"12-myristate",
"13-acetate",
"and",
"the",
"Ca2+",
"ionophore",
"ionomycin",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
554 | [
"Transient",
"transfections",
"using",
"reporter",
"constructs",
"with",
"multiples",
"of",
"transcription",
"factor",
"binding",
"sites",
"from",
"the",
"IL-2",
"promoter",
"[",
"distal",
"nuclear",
"factor",
"(",
"NF",
")",
"-AT",
",",
"proximal",
"NF-AT",
",",
"AP-1/Octamer",
"(",
"UPS",
")",
"or",
"NF-chi",
"B",
"(",
"TCEd",
")",
"sites",
"]",
"were",
"performed",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
1,
0,
1,
0,
1,
0,
0,
1,
2,
0,
1,
0,
0,
0,
0,
0,
0
] |
555 | [
"In",
"EBV-transformed",
"B",
"clones",
",",
"the",
"chi",
"B",
"site",
"exerted",
"the",
"strongest",
"inducible",
"activity",
";",
"the",
"NF-AT",
"binding",
"sites",
"showed",
"either",
"no",
"or",
"only",
"weak",
"activity",
"compared",
"to",
"Jurkat",
"T",
"cells",
"."
] | [
0,
0,
5,
6,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0
] |
556 | [
"An",
"IL-2",
"promoter",
"bearing",
"a",
"defective",
"NF-chi",
"B",
"site",
"was",
"completely",
"inactive",
"in",
"EBV-transformed",
"B",
"cells",
",",
"while",
"it",
"still",
"had",
"activity",
"in",
"Jurkat",
"T",
"cells",
"."
] | [
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0
] |
557 | [
"In",
"seven",
"EBV-B",
"cell",
"clones",
"or",
"lines",
"differing",
"in",
"their",
"capacity",
"to",
"secrete",
"IL-2",
",",
"the",
"activity",
"of",
"the",
"IL-2",
"promoter",
"correlated",
"well",
"with",
"the",
"status",
"of",
"IL-2",
"secretion",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
9,
0,
0
] |
558 | [
"Similarly",
",",
"a",
"human",
"immunodeficiency",
"virus",
"promoter",
",",
"whose",
"activity",
"is",
"controlled",
"through",
"chi",
"B",
"factors",
",",
"was",
"found",
"to",
"be",
"active",
"in",
"the",
"IL-2",
"producing",
"EBV-B",
"cells",
",",
"but",
"inactive",
"in",
"the",
"non-IL-2-producing",
"cells",
"."
] | [
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
559 | [
"Electrophoretic",
"mobility",
"shift",
"assays",
"using",
"protein",
"extracts",
"from",
"EBV-B",
"cells",
"and",
"the",
"IL-2",
"NF-chi",
"B",
"probe",
"revealed",
"the",
"constitutive",
"generation",
"of",
"chi",
"B",
"complexes",
"in",
"IL-2-secreting",
"cells",
"consisting",
"mainly",
"of",
"heterodimeric",
"p50/p65",
"complexes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
560 | [
"A",
"weaker",
"chi",
"B",
"complex",
"formation",
"and",
"faster-migrating",
"complexes",
"were",
"detected",
"in",
"non-IL-2-secreting",
"cells",
"."
] | [
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
561 | [
"These",
"results",
"demonstrate",
"that",
"the",
"IL-2",
"NF-chi",
"B",
"site",
"is",
"indispensable",
"for",
"the",
"activity",
"of",
"the",
"IL-2",
"promoter",
"in",
"EBV-transformed",
"B",
"cells",
",",
"whereas",
"other",
"transcription",
"factors",
"appear",
"to",
"be",
"less",
"important",
"for",
"IL-2",
"expression",
"in",
"these",
"cells",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0
] |
562 | [
"Latent",
"membrane",
"protein-1",
"induces",
"cyclin",
"D2",
"expression",
",",
"pRb",
"hyperphosphorylation",
",",
"and",
"loss",
"of",
"TGF-beta",
"1",
"-mediated",
"growth",
"inhibition",
"in",
"EBV-positive",
"B",
"cells",
"."
] | [
9,
10,
10,
0,
9,
10,
0,
0,
9,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
7,
8,
0
] |
563 | [
"The",
"normal",
"cell",
"cycle",
"is",
"regulated",
"by",
"several",
"molecules",
",",
"such",
"as",
"the",
"tumor-suppressor",
"protein",
"pRb",
",",
"the",
"G1",
"cyclins",
",",
"the",
"cyclin-dependent",
"kinases",
",",
"and",
"their",
"inhibitors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
9,
10,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
564 | [
"These",
"regulators",
"are",
"targeted",
"by",
"negative",
"growth",
"regulatory",
"signals",
",",
"such",
"as",
"that",
"provided",
"by",
"TGF-beta",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
565 | [
"Here",
",",
"we",
"show",
"that",
"the",
"presence",
"of",
"either",
"wild-type",
"EBV",
"or",
"its",
"transforming",
"latent",
"membrane",
"protein-1",
"(",
"LMP-1",
")",
"results",
"in",
"the",
"loss",
"of",
"TGF-beta",
"1",
"-mediated",
"growth",
"inhibition",
"in",
"human",
"B",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
7,
8,
8,
0
] |
566 | [
"Chemical",
"cross-linking",
"with",
"125I-labeled",
"TGF-beta",
"1",
"showed",
"an",
"essentially",
"normal",
"TGF-beta",
"receptor",
"profile",
"in",
"EBV-positive",
"and",
"EBV-negative",
"Burkitt",
"'s",
"lymphoma",
"cell",
"lines",
",",
"and",
"these",
"receptors",
"were",
"shown",
"to",
"be",
"functional",
"in",
"transducing",
"signals",
",",
"as",
"evidenced",
"by",
"the",
"TGF-beta",
"1",
"-mediated",
"modulation",
"of",
"junB",
"gene",
"expression",
"."
] | [
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
1,
2,
0,
0
] |
567 | [
"However",
",",
"TGF-beta",
"1",
"did",
"not",
"induce",
"dephosphorylation",
"of",
"pRb",
"in",
"EBV",
"(",
"or",
"LMP-1",
")",
"-positive",
"cells",
"as",
"opposed",
"to",
"EBV-negative",
"cells",
",",
"suggesting",
"a",
"dichotomy",
"in",
"the",
"TGF-beta",
"1",
"signaling",
"pathway",
"leading",
"to",
"separable",
"gene",
"regulatory",
"and",
"growth",
"inhibitory",
"responses",
"."
] | [
0,
0,
9,
10,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
568 | [
"Furthermore",
",",
"LMP-1",
"was",
"found",
"to",
"induce",
"the",
"expression",
"of",
"cyclin",
"D2",
";",
"normal",
"B",
"cells",
"or",
"EBV-negative",
"Burkitt",
"'s",
"lymphoma",
"cells",
"do",
"not",
"express",
"D-type",
"cyclins",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
7,
8,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
9,
0
] |
569 | [
"Taken",
"together",
",",
"these",
"data",
"point",
"to",
"a",
"potential",
"mechanism",
"underlying",
"EBV-mediated",
"B",
"cell",
"transformation",
"whereby",
"constitutive",
"induction",
"of",
"key",
"cell",
"cycle",
"regulators",
"by",
"LMP-1",
"can",
"lead",
"to",
"pRb",
"hyperphosphorylation",
"and",
"uncontrolled",
"cell",
"proliferation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0
] |
570 | [
"Does",
"thyroidectomy",
",",
"radioactive",
"iodine",
"therapy",
",",
"or",
"antithyroid",
"drug",
"treatment",
"alter",
"reactivity",
"of",
"patients",
"'",
"T",
"cells",
"to",
"epitopes",
"of",
"thyrotropin",
"receptor",
"in",
"autoimmune",
"thyroid",
"diseases",
"?"
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0
] |
571 | [
"The",
"effect",
"of",
"treatment",
"on",
"thyroid",
"antibody",
"production",
"and",
"T",
"cell",
"reactivity",
"to",
"thyroid",
"antigens",
"was",
"studied",
"in",
"15",
"patients",
"with",
"Graves",
"'",
"disease",
"(",
"GD",
")",
"before",
"and",
"after",
"thyroidectomy",
",",
"19",
"patients",
"with",
"GD",
"before",
"and",
"after",
"radioactive",
"iodine",
"(",
"RAI",
")",
"therapy",
",",
"and",
"9",
"patients",
"maintained",
"euthyroid",
"on",
"antithyroid",
"drugs",
"(",
"ATD",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
572 | [
"Twenty",
"subjects",
"matched",
"for",
"age",
"and",
"sex",
"without",
"known",
"thyroid",
"disease",
"served",
"as",
"controls",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
573 | [
"In",
"GD",
"patients",
",",
"the",
"responses",
"of",
"peripheral",
"blood",
"mononuclear",
"cells",
"(",
"PBMC",
")",
"and",
"TSH",
"receptor",
"(",
"TSHR",
")",
"-specific",
"T",
"cell",
"lines",
"to",
"recombinant",
"human",
"TSHR",
"extracellular",
"domain",
",",
"thyroglobulin",
",",
"and",
"TSHR",
"peptides",
"were",
"examined",
"on",
"the",
"day",
"of",
"surgery",
"or",
"RAI",
"therapy",
"(",
"day",
"0",
")",
"and",
"also",
"6-8",
"weeks",
"and",
"3-6",
"months",
"thereafter",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
7,
0,
0,
9,
10,
0,
9,
0,
0,
5,
6,
6,
0,
0,
9,
10,
0,
0,
0,
9,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
574 | [
"Reactivity",
"to",
"TSHR",
"peptides",
"before",
"surgery",
"was",
"heterogeneous",
"and",
"spanned",
"the",
"entire",
"extracellular",
"domain",
"."
] | [
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
575 | [
"Six",
"to",
"8",
"weeks",
"after",
"subtotal",
"thyroidectomy",
",",
"the",
"number",
"of",
"patients",
"'",
"PBMC",
"responding",
"to",
"any",
"peptide",
"and",
"the",
"average",
"number",
"of",
"recognized",
"peptides",
"decreased",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
576 | [
"A",
"further",
"decrease",
"in",
"the",
"T",
"cell",
"reactivity",
"to",
"TSHR",
"peptides",
"was",
"observed",
"3-6",
"months",
"after",
"surgery",
"."
] | [
0,
0,
0,
0,
0,
7,
8,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0
] |
577 | [
"The",
"responses",
"of",
"PBMC",
"from",
"Graves",
"'",
"patients",
"before",
"RAI",
"therapy",
"were",
"less",
"than",
"those",
"in",
"the",
"presurgical",
"group",
"."
] | [
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
578 | [
"Six",
"to",
"8",
"weeks",
"after",
"RAI",
"therapy",
",",
"the",
"number",
"of",
"patients",
"responding",
"to",
"any",
"peptide",
"and",
"the",
"average",
"number",
"of",
"recognized",
"peptides",
"increased",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
579 | [
"Three",
"to",
"6",
"months",
"after",
"RAI",
",",
"T",
"cell",
"responses",
"to",
"TSHR",
"peptides",
"were",
"less",
"than",
"those",
"6-8",
"weeks",
"after",
"RAI",
"therapy",
",",
"but",
"still",
"higher",
"than",
"the",
"values",
"on",
"day",
"0",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
580 | [
"Responses",
"of",
"PBMC",
"from",
"patients",
"with",
"GD",
",",
"maintained",
"euthyroid",
"on",
"ATD",
",",
"were",
"lower",
"than",
"those",
"before",
"surgery",
"or",
"RAI",
"therapy",
"."
] | [
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
581 | [
"The",
"reactivity",
"of",
"T",
"cell",
"lines",
"in",
"different",
"groups",
"reflected",
"a",
"pattern",
"similar",
"to",
"PBMC",
"after",
"treatment",
"."
] | [
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0
] |
582 | [
"TSHR",
"antibody",
"and",
"microsomal",
"antibody",
"levels",
"decreased",
"after",
"surgery",
",",
"but",
"increased",
"after",
"RAI",
"therapy",
"."
] | [
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
583 | [
"The",
"difference",
"in",
"the",
"number",
"of",
"recognized",
"peptides",
"by",
"patients",
"'",
"PBMC",
"before",
"RAI",
"and",
"surgery",
"may",
"reflect",
"the",
"effect",
"of",
"long",
"term",
"therapy",
"with",
"ATD",
"in",
"the",
"patients",
"before",
"RAI",
"vs.",
"the",
"shorter",
"period",
"in",
"patients",
"before",
"surgery",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
584 | [
"The",
"decreased",
"T",
"cell",
"reactivity",
"to",
"thyroid",
"antigens",
"after",
"thyroidectomy",
"could",
"be",
"the",
"result",
"of",
"removal",
"of",
"a",
"major",
"part",
"of",
"the",
"thyroid",
"gland",
"or",
"redistribution",
"of",
"suppressor-inducer",
"T",
"cells",
"."
] | [
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] |
585 | [
"The",
"increased",
"T",
"cell",
"response",
"after",
"RAI",
"therapy",
"is",
"probably",
"epitope",
"specific",
",",
"rather",
"than",
"a",
"response",
"to",
"the",
"whole",
"TSHR",
"molecule",
"."
] | [
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
586 | [
"Synchronous",
"recognition",
"of",
"peptides",
"158-176",
"and",
"248-263",
"is",
"important",
"for",
"the",
"development",
"of",
"GD",
",",
"and",
"the",
"loss",
"of",
"recognition",
"of",
"one",
"of",
"these",
"epitopes",
"may",
"be",
"an",
"early",
"sign",
"of",
"immune",
"remission",
"and",
"a",
"predictor",
"of",
"euthyroidism",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
587 | [
"Circumvention",
"of",
"tolerance",
"for",
"the",
"nuclear",
"T",
"cell",
"protein",
"TCF-1",
"by",
"immunization",
"of",
"TCF-1",
"knock-out",
"mice",
"."
] | [
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0,
0,
0,
9,
0,
0,
0
] |
588 | [
"Molecular",
"events",
"that",
"underlie",
"the",
"well-defined",
"phenotypic",
"changes",
"of",
"the",
"differentiating",
"thymocyte",
"are",
"poorly",
"understood",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0
] |
589 | [
"A",
"candidate",
"gene",
"to",
"control",
"thymocyte",
"differentiation",
",",
"T",
"cell",
"factor-1",
"(",
"TCF-1",
")",
"*",
"encodes",
"a",
"DNA-binding",
"protein",
"."
] | [
0,
0,
0,
0,
0,
7,
0,
0,
9,
10,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
590 | [
"Its",
"mRNA",
"expression",
"pattern",
"is",
"complex",
"during",
"embryogenesis",
",",
"yet",
"restricted",
"to",
"lymphocytes",
"postnatally",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0
] |
591 | [
"Expression",
"studies",
"on",
"TCF-1",
"protein",
"have",
"been",
"hampered",
"by",
"the",
"difficulty",
"to",
"raise",
"antibodies",
"due",
"to",
"extreme",
"evolutionary",
"conservation",
"."
] | [
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
592 | [
"TCF-1",
"knock-out",
"mice",
",",
"generated",
"recently",
"in",
"our",
"laboratory",
",",
"have",
"strongly",
"decreased",
"numbers",
"of",
"thymocytes",
",",
"but",
"are",
"otherwise",
"normal",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
0,
0,
0,
0,
0,
0
] |
593 | [
"We",
"have",
"used",
"these",
"mice",
"to",
"generate",
"anti-TCF-1",
"antibodies",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
9,
10,
0
] |
594 | [
"By",
"immunization",
"with",
"a",
"recombinant",
"fusion",
"protein",
",",
"we",
"show",
"that",
"TCF-1",
"knock-out",
"mice",
"readily",
"yield",
"antiserum",
"titers",
"against",
"human",
"and",
"mouse",
"TCF-1",
"protein",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] |
595 | [
"Wild-type",
"littermates",
"remain",
"unresponsive",
"to",
"TCF-1",
"while",
"they",
"mount",
"a",
"high-titer",
"antibody",
"response",
"to",
"the",
"fusion",
"protein",
",",
"Maltose",
"Binding",
"Protein",
"(",
"MBP",
")",
"."
] | [
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
9,
0,
0
] |
596 | [
"Subsequently",
",",
"TCF-1-specific",
"hybridomas",
"could",
"be",
"prepared",
"from",
"the",
"spleens",
"of",
"immunized",
"knock-out",
"mice",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
597 | [
"This",
"study",
"illustrates",
"the",
"almost",
"complete",
"tolerance",
"of",
"mice",
"for",
"human",
"TCF-1",
"and",
"demonstrates",
"that",
"this",
"tolerance",
"is",
"readily",
"broken",
"by",
"gene",
"knock-out",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
598 | [
"Furthermore",
",",
"the",
"usefulness",
"of",
"knock-out",
"mice",
"for",
"the",
"generation",
"of",
"monoclonal",
"antibodies",
"against",
"the",
"gene",
"product",
"of",
"interest",
"is",
"underscored",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
599 | [
"The",
"transcription",
"factor",
",",
"Nm23H2",
",",
"binds",
"to",
"and",
"activates",
"the",
"translocated",
"c-myc",
"allele",
"in",
"Burkitt",
"'s",
"lymphoma",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0
] |
600 | [
"We",
"have",
"identified",
"an",
"in",
"vivo",
"footprint",
"over",
"the",
"PuF",
"site",
"on",
"the",
"translocated",
"c-myc",
"allele",
"in",
"Burkitt",
"'s",
"lymphoma",
"cells",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] |