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701
[ "However", ",", "it", "was", "not", "detected", "in", "lymphoid", "cells", "MOLT4", "(", "T", "cell", ")", "and", "BALL1", "(", "B", "cell", ")", ",", "nor", "in", "K562", "erythroblasts", "." ]
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702
[ "Furthermore", ",", "a", "specific", "induction", "of", "AhR", "during", "monocytic", "differentiation", "was", "investigated", "in", "HL60", "and", "HEL", "cells", "." ]
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703
[ "HL60", "cells", "were", "induced", "to", "differentiate", "toward", "monocytes-macrophages", "by", "incubation", "with", "phorbol", "ester", ",", "showing", "a", "5-", "to", "2-fold", "increase", "of", "AhR", "mRNA", "." ]
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704
[ "The", "incubation", "with", "transforming", "growth", "factor", "beta", "1", "and", "1", "alpha", ",", "25-dihydroxyvitamin", "D3", "resulted", "in", "a", "5-", "to", "7-fold", "increase", "of", "AhR", "mRNA", "." ]
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705
[ "The", "HEL", "cells", "also", "exhibited", "a", "similar", "elevation", "of", "AhR", "mRNA", "level", ",", "when", "they", "had", "differentiated", "toward", "monocyte-macrophage", "cells", "by", "these", "combined", "inducers", ",", "but", "little", "change", "in", "the", "mRNA", "level", "was", "observed", "when", "the", "cells", "were", "induced", "to", "differentiate", "into", "other", "cell", "types", "." ]
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706
[ "Treatment", "of", "the", "differentiated", "HL60", "cells", "with", "3-methylcholanthrene", ",", "a", "ligand", "of", "AhR", ",", "induced", "the", "expression", "of", "the", "P450IA1", "gene", "." ]
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707
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708
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709
[ "Neutrophils", "and", "monocytes", "express", "high", "levels", "of", "PU.1", "(", "Spi-1", ")", "but", "not", "Spi-B", "." ]
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710
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711
[ "PU.1", "and", "Spi-B", "have", "been", "previously", "described", "as", "being", "predominantly", "expressed", "coordinately", "in", "macrophages", "and", "B", "cells", ",", "but", "their", "expression", "in", "early", "hematopoietic", "stages", "and", "during", "the", "course", "of", "myeloid", "differentiation", "to", "monocytes", "and", "macrophages", "or", "to", "neutrophils", "has", "not", "been", "extensively", "investigated", "." ]
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712
[ "Here", ",", "we", "report", "that", "PU.1", "mRNA", "is", "upregulated", "during", "myeloid", "differentiation", "of", "human", "purified", "CD34+", "cells", "and", "murine", "multipotential", "FDCP-mix", "A4", "cells", ",", "suggesting", "that", "PU.1", "is", "upregulated", "as", "an", "early", "event", "during", "differentiation", "of", "multipotential", "progenitor", "cells", "." ]
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713
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714
[ "PU.1", "is", "expressed", "at", "highest", "levels", "in", "mature", "human", "monocytes", "and", "human", "peripheral", "blood", "neutrophils", "." ]
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715
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716
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717
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718
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719
[ "Identification", "of", "a", "major", "positive", "regulatory", "element", "located", "5", "'", "to", "the", "human", "zeta-globin", "gene", "." ]
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720
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721
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722
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723
[ "When", "the", "constructs", "were", "transfected", "into", "OCIM1", "cells", ",", "which", "do", "not", "express", "zeta-globin", ",", "the", "zeta-globin", "promoters", "were", "at", "best", "20", "%", "as", "active", "as", "the", "alpha-globin", "promoters", "." ]
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724
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725
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726
[ "Point", "mutation", "of", "a", "GATA-1", "site", "at", "-230", "reduced", "promoter", "activity", "by", "37", "%", "." ]
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727
[ "Point", "mutation", "of", "a", "CCACC", "site", "at", "-240", "had", "no", "effect", "." ]
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728
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729
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730
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731
[ "Analysis", "of", "the", "role", "of", "protein", "kinase", "C-alpha", ",", "-epsilon", ",", "and", "-zeta", "in", "T", "cell", "activation", "." ]
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732
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733
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734
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735
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736
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737
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738
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739
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740
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741
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743
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745
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746
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749
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752
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800
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